4,388 results match your criteria Bile Duct Strictures

CT imaging patterns of paraduodenal pancreatitis: a unique clinicoradiological entity.

Clin Radiol 2022 May 16. Epub 2022 May 16.

Department of Radiology, Amrita Institute of Medical Sciences, Amrita Vishwavidyapeetham, Cochin, Kerala state, India.

Aim: To analyse the computed tomography (CT) findings of paraduodenal pancreatitis (PP) in patients treated at Amrita Institute of Medical Sciences.

Materials And Methods: Clinical, laboratory, and CT findings of 30 patients with PP treated from July 2007 to December 2020 were reviewed retrospectively.

Results: The average age of the patients was 45. Read More

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Differentiating between benign and malignant ampullary strictures: a prediction model using a nomogram based on CT imaging and clinical findings.

Eur Radiol 2022 May 19. Epub 2022 May 19.

Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehang-no, Chongno-gu, Seoul, 110-744, Republic of Korea.

Objectives: To construct a predictive nomogram for differentiating malignant from benign ampullary strictures using contrast-enhanced computed tomography (CT) findings combined with clinical findings.

Methods: In this retrospective study, 152 patients with ampullary stricture (98 benign and 54 malignant) who underwent contrast-enhanced CT were included. Various imaging findings of the ampulla, bile duct, main pancreatic duct, and periampullary area were evaluated and clinical findings including the presence of jaundice, carbohydrate antigen 19-9 level, and history of cholecystectomy were collected. Read More

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Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment.

BMJ Open Gastroenterol 2022 May;9(1)

Gastroenterology, Virginia Commonwealth University Health System, Richmond, Virginia, USA.

Liver transplantation (LT) is the only curative therapy in patients with end-stage liver disease. Long-term survival is excellent, yet LT recipients are at risk of significant complications. Biliary complications are an important source of morbidity after LT, with an estimated incidence of 5%-32%. Read More

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New technologies for indeterminate biliary strictures.

Transl Gastroenterol Hepatol 2022 25;7:22. Epub 2022 Apr 25.

Gastroenterology and Endoscopy Division, Instituto Ecuatoriano de Enfermedades Digestivas (IECED), Guayaquil, Ecuador.

An early and accurate diagnosis of biliary strictures yields optimal patient outcomes; however, endoscopic retrograde cholangiopancreatography (ERCP) with cytobrush/biopsy forceps has low sensitivity with a high number of false negatives. Various attempts to improve the accuracy of diagnosing indeterminate biliary strictures though ERCP-guided specimen acquisition have been proposed, such as with the use of fluorescence in situ hybridization, an endoscopic scraper, and the wire-grasping method, with modest to large improvements in sensitivity. Direct visualization of the biliary tree during peroral cholangioscopy has shown high sensitivity and specificity for the differentiation of neoplastic and non-neoplastic biliary lesions; however, there is no consensus on the visual characteristics of neoplastic lesions and moderate agreement between observers. Read More

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Secondary Sclerosing Cholangitis in a Critically Ill Patient with Severe SARS-CoV-2 Infection: A Possibly Emergent Entity during the Current Global Pandemic.

GE Port J Gastroenterol 2022 Mar 17;27:1-6. Epub 2022 Mar 17.

Serviço de Gastrenterologia, Hospital Beatriz Ângelo, Loures, Portugal.

A 46-year-old woman without previous history of hepatobiliary disease was admitted to the intensive care unit due to SARS-CoV-2 infection. Admission blood tests revealed impending hyperinflammation in the context of systemic inflammatory response syndrome. She required 12 days of mechanical ventilation and vasopressor support. Read More

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Diagnostic accuracy of probe-based confocal laser endomicroscopy and tissue sampling by endoscopic retrograde cholangiopancreatography in indeterminate biliary strictures: a meta‑analysis.

Sci Rep 2022 May 4;12(1):7257. Epub 2022 May 4.

Digestive Endoscopy Center, Shanxi Provincial People's Hospital, No. 29, Shuang ta si Street, Taiyuan, China.

Probe-based confocal laser endomicroscopy (pCLE), also known as optical biopsy, is a new endoscopic technique that provides real-time magnification of 1000 × microscopic tissue information to diagnose indeterminate biliary strictures. Tissue sampling by endoscopic retrograde cholangiopancreatography (ERCP) is routinely performed to evaluate indeterminate biliary strictures. To evaluate the accuracy of pCLE and tissue sampling by ERCP in the diagnosis of indeterminate biliary strictures, 18 articles were included from 2008 to 2021 through Embase, PubMed, Web of Science, and Cochrane library databases. Read More

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[Laparoscopic reconstructive Roux-en-Y hepaticojejunostomy].

Khirurgiia (Mosk) 2022 (4):86-90

Vishnevsky National Medical Research Center for Surgery, Moscow, Russia.

Intraoperative damage to the bile ducts following laparoscopic cholecystectomy is still one of the urgent problems of modern minimally invasive surgery. In some cases, these complications lead to patient disability, deterioration in their quality of life and need for redo surgery including technically difficult procedures. Modern endoscopic technologies are essential in the treatment of postoperative benign strictures of the common bile duct. Read More

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Assessing the incidence of complications and malignancies in the long-term management of benign biliary strictures with a percutaneous transhepatic drain.

Medicine (Baltimore) 2022 Mar 11;101(10):e29048. Epub 2022 Mar 11.

Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.

Abstract: Percutaneous drainage catheters (PDCs) are required for the management of benign biliary strictures refractory to first-line endoscopic treatment. While biliary patency after PDC placement exceeds 75%, long-term catheterization is occasionally necessary. In this article, we assess the outcomes of patients at our institution who required long-term PDC placement. Read More

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Endoscopic stenting for malignant biliary obstruction is technically successful in patients with preexisting duodenal stents.

Endosc Int Open 2022 Apr 14;10(4):E429-E433. Epub 2022 Apr 14.

Memorial Sloan Kettering Cancer Center - Medicine, Division of Gastroenterology, Hepatology and Nutrition, New York, New York, United States.

There are limited data on the success of endoscopic retrograde cholangiopancreatography (ERCP) in patients with malignant biliary and duodenal obstruction with a preexisting duodenal stent. The aim of this study was to evaluate patient and procedural outcomes of a cohort of patients with preexisting duodenal stents who underwent an attempt at ERCP for malignant biliary obstruction (MBO). This was a single-center retrospective study on consecutive patients with a preexisting duodenal stent who underwent attempted ERCP for MBO. Read More

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Significance of KRAS mutation testing in biliary brushing cytology specimens: A 10-year retrospective review.

Cancer Cytopathol 2022 Apr 13. Epub 2022 Apr 13.

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Background: Biliary strictures can be caused by benign and malignant conditions. A biliary duct brushing diagnosis can be challenging because of low cellularity and overlapping morphology among different entities, leading to a variable reported sensitivity. This study aimed to assess the value of KRAS mutation testing in adding cytological diagnosis of biliary duct brushings. Read More

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A review on biodegradable biliary stents: materials and future trends.

Bioact Mater 2022 Nov 3;17:488-495. Epub 2022 Feb 3.

Department of Materials Science, Fudan University, Shanghai, 200433, PR China.

Biliary stricture is defined as the reduction and narrowing of the bile duct lumen, which can be caused by many factors such as cancer and inflammation. Biliary stent placement can effectively alleviate benign and malignant biliary strictures. However, the commonly used plastic or metallic biliary stents are far from ideal and do not satisfy all clinical requirements,although several types of biodegradable biliary stents have been developed and used clinically. Read More

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November 2022

Long-term results of oversized balloon dilation for benign anastomotic biliary strictures: initial two-center experience.

Radiol Bras 2022 Mar-Apr;55(2):90-96

Second Department of Radiology, Interventional Radiology Unit, National and Kapodistrian University of Athens, Medical School, "Attikon" University Hospital, Athens, Greece.

Objective: To describe, assess the feasibility of, and quantify the long-term patency achieved with percutaneous transhepatic biliary dilation using the anastomotic biliary stricture (ABS) oversized balloon dilation technique as a single-step procedure for the treatment of benign anastomotic biliary strictures following hepatobiliary surgery.

Materials And Methods: This was a retrospective, two-center study including 16 consecutive cases of symptomatic benign biliary-enteric strictures. After assessment of the diameter of the bile duct by computed tomography or magnetic resonance imaging, the strictures were dilated with oversized balloons (40-50% larger than the bile duct diameter) and an external biliary-enteric drain was placed. Read More

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February 2021

Predictive factors for subsequent intrahepatic cholangiocarcinoma associated with hepatolithiasis: Japanese National Cohort Study for 18 years.

J Gastroenterol 2022 May 31;57(5):387-395. Epub 2022 Mar 31.

Department of Gastrointestinal and General Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

Background: Predictive factors for intrahepatic cholangiocarcinoma in long-term follow-up of hepatolithiasis are unknown. We thus conducted a cohort study to investigate the predictive factors for developing intrahepatic cholangiocarcinoma in hepatolithiasis.

Methods: This cohort is comprised of 401 patients registered in a nationwide survey of hepatolithiasis for 18 years of follow-up. Read More

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Xanthogranulomatous cholangitis mimicking cholangiocarcinoma: Case report and review of literature.

Int J Surg Case Rep 2022 Apr 9;93:106921. Epub 2022 Mar 9.

Department of Surgery, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.

Introduction: Xanthogranulomatous cholangitis is an extremely rare diagnosis and is believed to be an extension of xanthogranulomatous cholecystitis, a benign inflammatory process characterized by lipid-laden foamy macrophages (called "xanthoma cells") occurring in a background of chronic inflammation consisting of lymphocytes, plasma cells, and eosinophils. Here, we report a case of xanthogranulomatous cholangitis mimicking cholangiocarcinoma.

Case Presentation: A 72 year old male with history of recurrent cholangitis had preoperative workup highly suggestive of intrahepatic cholangiocarcinoma. Read More

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Comparison of MRCP and ERCP findings: A retrospective secondary data analysis.

J Pak Med Assoc 2022 Feb;72(2):284-286

Department of Gastroenterology, Medical Teaching Institute, Lady Reading Hospital, Peshawar, Pakistan.

Objective: To compare the findings of magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography in patients presenting with bile duct disorders.

Methods: The retrospective secondary-data study was conducted at the Gastroenterology Department of Lady Reading Hospital, Peshawar, Pakistan, and comprised data of patients who presented with bile duct disorders from June2019 to May2020. Data was analysed using SPSS 25. Read More

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February 2022

Peroral cholangioscopy: Update on the state-of-the-art.

World J Gastrointest Endosc 2022 Feb;14(2):63-76

David Geffen School of Medicine at UCLA, Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA 91342, United States.

Peroral cholangioscopy (POC) is an endoscopic procedure that allows direct intraductal visualization of the biliary tract. POC has emerged as a vital tool for indeterminate biliary stricture evaluation and treatment of difficult biliary stones. Over several generations of devices, POC has fulfilled additional clinical needs where other diagnostic or therapeutic modalities have been inadequate. Read More

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February 2022

Spyglass percutaneous transhepatic lithotripsy of symptomatic recurrent lithiasis of the intrahepatic bile duct with distal stenosis.

Acta Biomed 2022 Mar 14;93(1):e2022020. Epub 2022 Mar 14.


In patients with symptomatic intrahepatic biliary lithiasis, the treatment is usually discussed by a multidisciplinary team. Although hepatectomy is considered as definitive treatment, when lobar atrophy is absent, endoscopic procedures are frequently proposed as first-line treatment due the low invasiveness and for sparing liver parenchyma. Percutaneous route is used in case of peroral approach failure. Read More

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Tardive peritonitis after the endoscopic ultrasound-guided hepaticogastorostomy: A case report.

DEN open 2022 Apr 24;2(1):e77. Epub 2021 Nov 24.

Department of Endoscopy the Jikei University School of Medicine Tokyo Japan.

Endoscopic ultrasound-guided biliary drainage (EUS-BD) has become popular as a new drainage technique for malignant biliary strictures. Although EUS-BD has been reported to show high technical and clinical success rates, the rate of adverse events is 15%. In particular, peritonitis, which is generally caused by bile leakage from the aspiration side during the procedure and occurs within a few days after EUS-BD, needs to be considered as it can be fatal. Read More

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Factors predicting 30-day mortality after ERCP in patients with inoperable malignant hilar biliary obstruction: a single tertiary referral centre experience and systematic review.

BMJ Open Gastroenterol 2022 Mar;9(1)

Department of Gastroenterology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Objective: There is a paucity of studies in the literature body evaluating short term outcomes following endoscopic retrograde cholangiopancreatography (ERCP) in patients with inoperable malignant hilar biliary obstruction (MHBO). We aimed to primarily evaluate 30-day mortality in these patients and secondarily, conduct a systematic review of studies reporting 30-day mortality.

Design: We conducted a retrospective analysis of all patients with inoperable MHBO who underwent ERCP at Leeds Teaching Hospitals NHS Trust between February 2015 and September 2020. Read More

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Chronic pancreatitis for the clinician. Complications and special forms of the disease. Interdisciplinary position paper of the Catalan Society of Digestology (SCD) and the Catalan Pancreatic Society (SCPanc).

Minerva Gastroenterol (Torino) 2022 Mar 8. Epub 2022 Mar 8.

Gastroenterology Department, Hospital Clínic, University of Barcelona, CIBEREHD IDIBAPS, Barcelona, Spain.

Chronic pancreatitis tends to develop a number of complications that may constitute the form of presentation of the disease. Some societies have issued guidelines for diagnosis and treatment of chronic pancreatitis complications, but the level of evidence for any topic is usually low and recommendations tend to be weak. We aimed at providing defined position statements for the clinician based on updated review of published literature and on multidisciplinary expert agreement. Read More

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Use of catheter-based cholangioscopy in the diagnosis of indeterminate stenosis: a multi-centre experience.

Minerva Gastroenterol (Torino) 2022 Mar 8. Epub 2022 Mar 8.

Endoscopy Unit, Fondazione Istituto G. Giglio, Cefalù, Palermo, Italy.

Background: Direct bile ducts visualization through cholangioscopy has gained popularity due to its better diagnostic accuracy than a standard ERCP in indeterminate biliary stricture.

Aim: We aimed to review our catheter-based cholangioscopy interventions in patients with indeterminate biliary stenosis, using the SpyGlass Direct Visualization System (SDVS) and summarize our experience in terms of procedures and results.

Results: we collected 25 consecutive patients with indeterminate biliary stricture over 3 years. Read More

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The Utility of Biliary Manometry in Assessing Early Catheter Removal After Percutaneous Balloon Dilatation of Hepaticojejunostomy Strictures.

Cureus 2022 Mar 2;14(3):e22761. Epub 2022 Mar 2.

Department of Surgical Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, IND.

Background and objective Percutaneous balloon dilatation followed by long-term internal-external biliary catheter (IEBC) placement is the standard radiological management for postoperative hepaticojejunostomy (HJ) strictures. The treatment is considered successful when cholangiography shows a free flow of contrast across the anastomosis and the patient passes a "clinical test". However, these tests may not be suitable predictors of long-term successful treatment outcomes. Read More

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Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease.

Cell Stem Cell 2022 03;29(3):355-371.e10

Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK. Electronic address:

Biliary diseases can cause inflammation, fibrosis, bile duct destruction, and eventually liver failure. There are no curative treatments for biliary disease except for liver transplantation. New therapies are urgently required. Read More

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Exocrine pancreas insufficiency in chronic pancreatitis - Risk factors and associations with complications. A multicentre study of 1869 patients.

Pancreatology 2022 Apr 16;22(3):374-380. Epub 2022 Feb 16.

Paediatric Department, Haukeland University Hospital, Bergen, Norway. Electronic address:

Background/objectives: There is scarce information about risk factors for exocrine pancreas insufficiency (EPI) in chronic pancreatitis (CP), and how it associates with other complications. The aim of the present study was to examine risk factors for EPI and associations to procedures and other CP related complications in a large, Northern European cohort.

Patients And Methods: We retrieved cross-sectional data on demographics, status on EPI, aetiological risk factors for CP, CP related complications as well as surgical and endoscopic treatment from the Scandinavian Baltic Pancreatic Club Database. Read More

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Preventive effect of biodegradable stents on biliary stricture and fibrosis after biliary anastomosis in a porcine model.

Ann Surg Treat Res 2022 Feb 4;102(2):90-99. Epub 2022 Feb 4.

Korea Textile Development Institute, Daegu, Korea.

Purpose: The current drain tubes for preventing surgically biliary anastomotic stricture are not naturally and easily removed. If a drain tube using biodegradable material is easily available and the degradation time of the tube is well controlled, surgical anastomotic stricture and fibrosis could be prevented. The aim of this animal study was to evaluate the preventive effect of novel biodegradable stents (BS) on biliary stricture and fibrosis after duct-to-duct (DD) biliary anastomosis. Read More

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February 2022

Increased ERCP Volume Improves Cholangiogram Interpretation - A New Performance Measure for ERCP Training?

Clin Endosc 2022 Feb 4. Epub 2022 Feb 4.

Southampton Interventional Endoscopy Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Background/aims: Cholangiogram interpretation is not used as a key performance indicator (KPI) of endoscopic retrograde cholangiopancreatography (ERCP) training, and national societies recommend different minimum numbers per annum to maintain competence. This study aimed to determine the relationship between correct ERCP cholangiogram interpretation and experience.

Methods: One hundred fifty ERCPists were surveyed to appropriately interpret ERCP cholangiographic findings. Read More

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February 2022

More Endoscopy-Based Brushing Passes Improve the Detection of Malignant Biliary Strictures: A Multicenter Randomized Controlled Trial.

Am J Gastroenterol 2022 May 2;117(5):733-739. Epub 2022 Feb 2.

Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Introduction: Endoscopic biliary brushing is the most common method used for sampling in patients with malignant biliary strictures (MBSs); however, its sensitivity is relatively low. There is still no consensus on endoscopy-based biliary brushing, although brushing 10 times in 1 specimen is routinely performed. This study was designed to compare the sensitivity of brush cytology for 10, 20, or 30 brushing times of a pass in 1 specimen in patients with MBSs. Read More

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Biliary complications in pediatric liver transplantation: findings of percutaneous transhepatic cholangiography in a large single-center cohort.

Pediatr Radiol 2022 May 2;52(6):1061-1074. Epub 2022 Feb 2.

Department of Radiology, ASST Papa Giovanni XXIII Hospital, 24127, Bergamo, Italy.

Background: Although biliary complications after orthotopic liver transplantation represent a common source of morbidity and mortality, decreasing graft survival, consensus is lacking on their management in the pediatric population.

Objective: The aim of this study was to present the prevalence of such biliary complications and their interventional radiologic management with representative images.

Materials And Methods: This retrospective study reports our experience with percutaneous transhepatic cholangiography in the management of biliary complications after orthotopic liver transplantation in pediatric patients. Read More

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Migration of fully covered self-expandable metallic stents used to treat anastomotic strictures after orthotopic liver transplantation: A single-center, retrospective analysis.

Medicine (Baltimore) 2022 Jan;101(4):e28685

Division of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University, Shulan International Medical College, #848 Dongxin Road, Hangzhou, Zhejiang, P.R. China.

Abstract: Insertion of a fully covered self-expandable metallic stent (FCEM) through endoscopic retrograde cholangiopancreatography is an effective solution for biliary anastomotic stricture following orthotopic liver transplantation (OLT). However, FCEM migration continues to plague patients. This study aimed to evaluate the FCEM migration rate in our center, and to investigate the factors increasing the migration risk for FCEM. Read More

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January 2022

Portal Cavernoma Cholangiopathy in Children: An Evaluation Using Magnetic Resonance Cholangiography and Endoscopic Ultrasound.

J Clin Exp Hepatol 2022 Jan-Feb;12(1):135-143. Epub 2021 Mar 5.

Division of Paediatric Gastroenterology, Hepatology & Nutrition, Post Graduate Institute of Medical Education & Research, Chandigarh, 160012, India.

Background: Portal cavernoma cholangiopathy (PCC) refers to abnormalities of the extra- and intrahepatic bile ducts in patients with portal cavernoma. The literature on PCC in children is very scarce. This study aimed at characterizing PCC in children with extrahepatic portal venous obstruction (EHPVO) using endoscopic ultrasound (EUS) and magnetic resonance cholangiography/portovenography (MRC/MRPV). Read More

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