163,169 results match your criteria Best practice & research. Clinical gastroenterology[Journal]


Multicenter evaluation of a novel ROS1 immunohistochemistry assay (SP384) for detection of ROS1 rearrangements in a large cohort of lung adenocarcinoma patients.

J Thorac Oncol 2019 Apr 15. Epub 2019 Apr 15.

Université Côte d'Azur, University Hospital Federation OncoAge, Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, Nice, France;; Université Côte d'Azur, CNRS, INSERM, Institute of Research on Cancer and Ageing of Nice (IRCAN), University Hospital Federation OncoAge, Nice, France;; Université Côte d'Azur, University Hospital Federation OncoAge, Hospital-Related Biobank (BB-0033-00025), Pasteur Hospital, Nice, France;. Electronic address:

Introduction: The detection of a ROS1 rearrangement in advanced and metastatic lung adenocarcinoma (LUAD) lead to a targeted treatment with tyrosine kinase inhibitors, with favorable progression-free survival and overall survival of the patients. Thus, it is mandatory to screen for the ROS1 rearrangement in all these patients. ROS1 rearrangements can be detected using break-apart fluorescence in situ hybridization (FISH), which is the "gold standard"; however, ROS1 immunohistochemistry (IHC) can be used as a screening test since it is widely available, easy and rapid to perform, and cost-effective. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.03.024DOI Listing

Narrow-band Imaging for Detection of Neoplasia at Colonoscopy: a Meta-analysis of Data From Individual Patients in Randomized Controlled Trials.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, and Oxford NIHR Biomedical Research Centre, Oxford OX3 9DU, UK. Electronic address:

Background & Aims: Adenoma detection rate (ADR) is an important quality assurance measure for colonoscopy. Some studies suggest that narrow band imaging (NBI) may be more effective at detection of adenomas than white-light endoscopy (WLE) when bowel preparation is optimal. We conducted a meta-analysis of data from individual patients in randomized controlled trials that compared the efficacy of NBI to WLE in detection of adenomas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193570
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http://dx.doi.org/10.1053/j.gastro.2019.04.014DOI Listing
April 2019
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Issues and current standards of controls in microbiome research.

FEMS Microbiol Ecol 2019 May;95(5)

Department of Medical Microbiology, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands.

Good scientific practice is important in all areas of science. In recent years this has gained more and more attention, especially considering the 'scientific reproducibility crisis'. While most researchers are aware of the issues with good scientific practice, not all of these issues are necessarily clear, and the details can be very complicated. Read More

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https://academic.oup.com/femsec/article/doi/10.1093/femsec/f
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http://dx.doi.org/10.1093/femsec/fiz045DOI Listing
May 2019
1 Read

"Posting policies don't change because there is peace or war": the staff deployment challenges for two large health employers during and after conflict in Northern Uganda.

Hum Resour Health 2019 Apr 17;17(1):27. Epub 2019 Apr 17.

ReBUILD Consortium and Department of International Public Health, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, United Kingdom.

Background: Between 1986 and 2006, the Acholi region in Uganda experienced armed conflict which disrupted the health system including human resources. Deployment of health workers during and after conflict raises many challenges for managers due to issues of security and staff shortage. We explored how deployment policies and practices were adapted during the conflict and post-conflict periods with the aim of drawing lessons for future responses to similar conflicts. Read More

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http://dx.doi.org/10.1186/s12960-019-0361-9DOI Listing

Simulation In Surgical Training: Prospective Cohort Study Of Access, Attitudes And Experiences Of Surgical Trainees In The Uk And Ireland.

Int J Surg 2019 Apr 14. Epub 2019 Apr 14.

Association of Surgeons in Training, 35-43 Lincoln's Inn Fields, London, WC2A 3PE.

Background: Surgical training is evolving, and simulation is becoming more important as a way to expedite the early learning curve and augment surgical techniques. With novel technology, and innovation, major changes are possible in how surgeons are trained. The integration of these concepts into the surgical curriculum may drive up educational standards and enhance patient safety. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.04.004DOI Listing

Guidelines for Postoperative care in Cesarean Delivery: Enhanced Recovery After Surgery (ERAS) Society Recommendations (Part 3 ).

Am J Obstet Gynecol 2019 Apr 14. Epub 2019 Apr 14.

Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR, United States.

This Enhanced Recovery After Surgery (ERAS) Guideline for postoperative care in Cesarean Delivery (CD) will provide best practice, evidenced-based, recommendations for post-operative care with, primarily a maternal focus. The pathway process for scheduled and unscheduled CD, for this ERAS CD guideline, will consider time from completion of cesarean until maternal hospital discharge. The literature search (1966-2017) used Embase and PubMed to search medical subject headings including "Cesarean Section", "Cesarean Delivery", "Cesarean Section Delivery" and all post-operative ERAS® items. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029378193057
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http://dx.doi.org/10.1016/j.ajog.2019.04.012DOI Listing
April 2019
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Psychometric validation of Anti-Clot Treatment Scale and Treatment Satisfaction Questionnaire for Medication version II in Japanese patients with atrial fibrillation.

J Med Econ 2019 Apr 17. Epub 2019 Apr 17.

i Modus Outcomes Ltd , Letchworth Garden City , UK.

Aims: The Anti-Clot Treatment Scale (ACTS) and Treatment Satisfaction Questionnaire for Medication version II (TSQM-II) are validated treatment satisfaction patient-reported outcome (PRO) instruments. The ACTS includes two domains: Burdens and Benefits; the TSQM-II includes four: Effectiveness, Side Effects, Convenience, and Global Satisfaction. Japanese-language versions of the ACTS and TSQM-II have been developed and linguistically validated. Read More

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http://dx.doi.org/10.1080/13696998.2019.1609003DOI Listing

Establishing Consensus on the Best Practice Guidelines for Use of Halo Gravity Traction for Pediatric Spinal Deformity.

J Pediatr Orthop 2019 Apr 15. Epub 2019 Apr 15.

Department of Orthopaedic Surgery, Columbia University Medical Center, New York.

Background: Although halo gravity traction (HGT) has been used to treat children with severe spinal deformity for decades, there is a distinct lack of high-quality evidence to speak to its merits or to dictate ideal manner of implementation. In addition, no guidelines exist to drive research or assist surgeons in their practice. The aim of this study was to establish best practice guidelines (BPG) using formal techniques of consensus building among a group of experienced pediatric spinal deformity surgeons to determine ideal indications and implementation of HGT for pediatric spinal deformity. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001379DOI Listing
April 2019
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Prevention of catheter-associated urinary tract infection in neurological post-operation patients: a best practice implementation project.

JBI Database System Rev Implement Rep 2019 Apr 15. Epub 2019 Apr 15.

Indiana Center for Evidence Based Nursing Practice: a Joanna Briggs Institute Affiliated Group.

Objective: The objective of this evidence based implementation project was to promote evidence based practice in the prevention of catheter-associated urinary tract infection (CAUTI) in the neurology and neurosurgery units of a Taipei hospital.

Introduction: Catheter-associated urinary tract infection has been associated with increased morbidity, mortality, hospital costs and length of stay. Urinary drainage systems are often reservoirs of infection in patients, thus effective prevention of CAUTI requires an evidence-based approach. Read More

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http://dx.doi.org/10.11124/JBISRIR-2017-003945DOI Listing
April 2019
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Anesthesia-administered sedation for endoscopic retrograde cholangiopancreatography: monitored anesthesia care or general endotracheal anesthesia?

Curr Opin Anaesthesiol 2019 Apr 15. Epub 2019 Apr 15.

Division of Gastroenterology, Washington University School of Medicine, Saint Louis, Missouri, USA.

Purpose Of Review: The decision to undertake monitored anesthesia care (MAC) or general endotracheal anesthesia (GEA) for patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) is influenced by many factors. These include locoregional practice preferences, procedure complexity, patient position, and comorbidities. We aim to review the data regarding anesthesia-administered sedation for ERCP and identify the impact of airway management on procedure success, adverse event rates and endoscopy unit efficiency. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000741DOI Listing

[Archwire segmentation: a solution to the problems involved in treating atypical cases].

Orthod Fr 2019 Mar 17;90(1):65-74. Epub 2019 Apr 17.

56 rue des Tournelles, 75004 Paris, France.

Introduction: Asymmetrical orthodontic cases frequently prove very difficult to correct. Anchorage mini-screws are often needed to treat these cases when the malocclusion is of maxillary origin. Nonetheless, a precise biomechanical assessment must be made to avoid undesirable sideeffects resulting from the mechanics used. Read More

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https://www.orthodfr.org/10.1051/orthodfr/2019006
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http://dx.doi.org/10.1051/orthodfr/2019006DOI Listing
March 2019
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Do Community Treatment Orders in Psychiatry Stand Up to Principalism: Considerations Reflected through the Prism of the Convention on the Rights of Persons with Disabilities.

J Law Med Ethics 2019 Mar;47(1):126-133

Giles Newton-Howes, B.A., B.Sc., M.B.Ch.B., M.R.C.Psych., F.R.A.N.Z.C.P., PostDip.C.B.T., Ph.D., is an associate professor in the department of psychological medicine, University of Otago, Wellington. He is seconded to Te-Upoko-me-Te-Karuo-Te-Ika, the public health service that delivers mental health care to the lower part of the North Island of New Zealand, where he works as a consultant psychiatrist.

Compulsory psychiatric treatment is the norm in many Western countries, despite the increasingly individualistic and autonomous approach to medical interventions. Community Treatment Orders (CTOs) are the singular best example of this, requiring community patients to accept a variety of interventions, both pharmacological and social, despite their explicit wish not to do so. The epidemiological, medical/treatment and legal intricacies of CTOs have been examined in detail, however the ethical considerations are less commonly considered. Read More

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http://dx.doi.org/10.1177/1073110519840492DOI Listing

Be explicit: Defining the difference between the Office of Diversity & Inclusion and the Office of Diversity & Equity.

Med Teach 2019 Apr 17:1-2. Epub 2019 Apr 17.

a Hackensack Meridian School of Medicine , Seton Hall University , Kingsland St , Nutley , NJ , USA.

Diversity, inclusion, and equity are recognized as educational priorities and strategies for excellence across medical education. However, an inadvertent consequence of this push for best practice is that these terms are used interchangeably. This personal view intends to highlight the importance of language in an office of diversity and how it can potentially exacerbate the disparities it aims to alleviate. Read More

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http://dx.doi.org/10.1080/0142159X.2019.1597261DOI Listing

Predictors of dental care utilization in north-central Appalachia in the USA.

Community Dent Oral Epidemiol 2019 Apr 17. Epub 2019 Apr 17.

Center for Oral Health Research in Appalachia, University of Pittsburgh, Pittsburgh, Pennsylvania.

Objectives: Dental utilization is an important determinant of oral health and well-being. The aim of this study was to evaluate potential associations between a variety of biopsychosocial factors and dental utilization in north-central Appalachia, USA, a region where oral health disparities are profound.

Methods: This study used household-based data from the Center for Oral Health Research in Appalachia (COHRA1) study in north-central Appalachia, including 449 families with 868 adults. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cdoe.12453
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http://dx.doi.org/10.1111/cdoe.12453DOI Listing
April 2019
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Practical guidance for engaging patients in health research, treatment guidelines and regulatory processes: results of an expert group meeting organized by the World Health Organization (WHO) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Liège, Belgium.

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients' needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Read More

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http://dx.doi.org/10.1007/s40520-019-01193-8DOI Listing

The human embryo, subjectivity and legal capacity. Notes in the light of art. 1 of the Italian law on "medically assisted procreation".

Clin Ter 2019 Mar-Apr;170(2):e102-e107

School of Law, University of Camerino.

Aim: This paper aims to examine the legal status of the human embryo taking into consideration Article 1 of the Italian law on medically assisted procreation, which protects the human embryo, which is recognised as an individual holding the same rights as already born children. The progressive increase in legal decisions regarding reproductive technologies requires a re-examination of the traditional legal categories of "subjectivity" and legal capacity, and a deeper understanding of the status of the human embryo as a subject, or individua.

Materials And Methods: The following sources were searched: Institutional websites, Research Centre for Social Investments reports, updated jurisprudence and Rulings of Italian Constitutional Court and European Court of Human Rights. Read More

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http://dx.doi.org/10.7417/CT.2019.2118DOI Listing
April 2019
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MetaMSD: meta analysis for mass spectrometry data.

PeerJ 2019 10;7:e6699. Epub 2019 Apr 10.

School of Community Health Sciences, University of Nevada - Reno, Reno, NV, United States of America.

Mass spectrometry-based proteomics facilitate disease understanding by providing protein abundance information about disease progression. For the same type of disease studies, multiple mass spectrometry datasets may be generated. Integrating multiple mass spectrometry datasets can provide valuable information that a single dataset analysis cannot provide. Read More

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https://peerj.com/articles/6699
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http://dx.doi.org/10.7717/peerj.6699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462182PMC
April 2019
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Setting weights for fifteen CHNRI criteria at the global and regional level using public stakeholders: an Amazon Mechanical Turk study.

J Glob Health 2019 Jun;9(1):010702

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

Introduction: Stakeholder involvement has been described as an indispensable part of health research priority setting. Yet, more than 75% of the exercises using the Child Health and Nutrition Research Initiative (CHNRI) methodology have omitted the step involving stakeholders in priority setting. Those that have used stakeholders have rarely used the public, possibly due to the difficulty of assembling and/or accessing a public stakeholder group. Read More

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http://dx.doi.org/10.7189/jogh.09.010702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445564PMC

What enables older people to continue with their falls prevention exercises? A qualitative systematic review.

BMJ Open 2019 Apr 15;9(4):e026074. Epub 2019 Apr 15.

RCN RI, Royal College of Nursing Research Institute, Warwick Medical School, University of Warwick, Coventry, UK.

Objectives: To review the qualitative literature that explores the barriers and facilitators to continued participation in falls prevention exercise after completion of a structured exercise programme.

Design: A systematic literature review with thematic synthesis of qualitative studies exploring older adults' experiences of continued participation in falls prevention exercise.

Data Sources: Comprehensive searches were conducted in MEDLINE, PSYCHinfo, AMED, ASSIA, CINAHL and EMBASE from inception until November 2017. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026074DOI Listing

Estimation of early life endogenous surfactant pool and CPAP failure in preterm neonates with RDS.

Respir Res 2019 Apr 16;20(1):75. Epub 2019 Apr 16.

Division of Pediatrics and Neonatal Critical Care, Medical Center "A.Béclère", South Paris University Hospitals, AP-HP, Paris, France.

Background: It is not known if the endogenous surfactant pool available early in life is associated with the RDS clinical course in preterm neonates treated with CPAP. We aim to clarify the clinical factors affecting surfactant pool in preterm neonates and study its association with CPAP failure.

Methods: Prospective, pragmatic, blind, cohort study. Read More

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http://dx.doi.org/10.1186/s12931-019-1040-zDOI Listing

A mixed-methods approach to understanding partnership experiences and outcomes of projects from an integrated knowledge translation funding model in rehabilitation.

BMC Health Serv Res 2019 Apr 16;19(1):230. Epub 2019 Apr 16.

School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada.

Background: Integrated knowledge translation (IKT) can optimize the uptake of research evidence into clinical practice by incorporating knowledge users as equal partners in the entire research process. Although several studies have investigated stakeholder involvement in research, the literature on partnerships between researchers and clinicians in rehabilitation and their impact on clinical practice is scarce. This study described the individual research projects, the outcomes of these projects on clinical practice and the partnership experiences of an initiative that funds IKT projects co-led by a rehabilitation clinician and a researcher. Read More

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https://bmchealthservres.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12913-019-4061-xDOI Listing
April 2019
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Medical education today: all that glitters is not gold.

BMC Med Educ 2019 Apr 16;19(1):110. Epub 2019 Apr 16.

Department of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), 6431 Fannin St., MSB2.276, Houston, TX, 77005, USA.

Background: The medical education system based on principles advocated by Flexner and Osler has produced generations of scientifically grounded and clinically skilled physicians whose collective experiences and contributions have served medicine and patients well. Yet sweeping changes launched around the turn of the millennium have constituted a revolution in medical education. In this article, a critique is presented of the new undergraduate medical education (UME) curricula in relationship to graduate medical education (GME) and clinical practice. Read More

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https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909
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http://dx.doi.org/10.1186/s12909-019-1535-9DOI Listing
April 2019
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The current evidence-based management of distal radial fractures: UK perspectives.

J Hand Surg Eur Vol 2019 Apr 16:1753193419843201. Epub 2019 Apr 16.

1 Academic Team of Musculoskeletal Surgery, Leicester General Hospital, Leicester, UK.

Distal radial fractures are extremely common injuries, yet many basic questions remain unanswered about their optimum management. Recently in the United Kingdom several guideline development groups have produced national standards and best-practice guidelines based on review of the best available evidence and expert knowledge. All guideline groups agree that when surgery is needed for dorsally displaced distal radial fractures, that can be reduced closed, K-wire fixation and cast immobilization, should be offered. Read More

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http://dx.doi.org/10.1177/1753193419843201DOI Listing

Effects of the amount of practice and time interval between practice sessions on the retention of internal models.

PLoS One 2019 16;14(4):e0215331. Epub 2019 Apr 16.

School of Humanities and Social Sciences, Waseda University, Tokyo, Japan.

The amount of practice and time interval between practice sessions are important factors that influence motor learning efficiency. Here, we aimed to reveal the relationship between the retention and consolidation of a new internal model, and the amount of practice and time interval between practice sessions. We employed a visuomotor rotation tracking task to test the hypotheses that (1) a new internal model consolidates owing to extensive practice after reaching a task performance plateau and (2) a longer time interval between practice sessions makes it difficult to activate a new internal model. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215331PLOS
April 2019
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Reverse Educational Distance: Exploring a novel concept to enhance Resident-As-Teacher curricula.

Med Teach 2019 Apr 16:1-7. Epub 2019 Apr 16.

b Centre for Medical Education, Faculty of Medicine , McGill University , Montreal , Canada.

Purpose: The learning benefits associated with residents teaching peers and junior trainees are well documented. However, the concept of Reverse Educational Distance (RED), when residents teach an academically senior audience, is poorly described.

Methods: We explored Pediatric residents' and community health care providers' (cHCPs) perceptions of a RED teaching intervention, whereby residents would engage in teaching cHCPs. Read More

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https://www.tandfonline.com/doi/full/10.1080/0142159X.2019.1
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http://dx.doi.org/10.1080/0142159X.2019.1578875DOI Listing
April 2019
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Supporting Data vs Patient Requests in Oncology: When the Two Don't Coincide.

Oncology (Williston Park) 2019 04;33(4):156-8

Relationships between cancer patients and their oncologists flourish in a milieu of trust and goodwill. However, at times cancer patients may express strong preferences for medical tests, treatments, or other interventions that are not beneficial. Actively challenging these requests can be difficult and may threaten the patient-physician relationship. Read More

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April 2019
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Child Passenger Safety: AAP Updates Best Practice Recommendations.

Authors:
Jennifer Wilkes

Am Fam Physician 2019 Apr;99(8):525-526

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The human risks of bias in medical and rehabilitation research and practice: the 8 I's.

Authors:
Antti Malmivaara

Eur J Phys Rehabil Med 2019 Apr 15. Epub 2019 Apr 15.

Centre for Health and Social Economics, National Institute for Health and Welfare Mannerheimintie, Helsinki, Finland -

Background: The human mind is liable to make biased interpretations. The biomedical paradigm supposes that an objective truth can be reached with rigorous scientific methods. Human risk of bias is defined in this paper as threats to validity of study results that cannot be controlled even by rigorous scientific methods. Read More

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http://dx.doi.org/10.23736/S1973-9087.19.05807-6DOI Listing

Neoadjuvant Chemotherapy in Non-Metastatic Breast Cancer- A Study on Practice Trends in a Regional Cancer Treatment Service.

Intern Med J 2019 Apr 16. Epub 2019 Apr 16.

Medical Oncology, Palmerston North Hospital, New Zealand.

Aims: Neoadjuvant Chemotherapy (NACT) is increasingly used for managing locally advanced and high risk non-metastatic breast cancer(NMBC). The goal of this study is to describe trends in NACT use, assess compliance to best practice recommendations and determine treatment response rates in a regional cancer treatment service.

Method: In this retrospective cross- sectional study, electronic records of patients who underwent NACT in centres covered by the Midcentral Regional Cancer Treatment Service (RCTS) in 2013 and 2017 were reviewed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imj.14326
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http://dx.doi.org/10.1111/imj.14326DOI Listing
April 2019
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Virtual Care 2.0-a Vision for the Future of Data-Driven Technology-Enabled Healthcare.

Curr Treat Options Cardiovasc Med 2019 Apr 15;21(5):21. Epub 2019 Apr 15.

Department of Medicine, Divisions of General Internal Medicine and Biomedical Informatics, Chief Medical Information Officer of Population Health, University of California San Diego, 9560 Towne Centre Drive, San Diego, CA, 92121, USA.

A busy community cardiologist finished reading eight echocardiograms over lunch and started clinic at 1 pm. As three patients waited, "Jane," a 45-year-old graphic designer was seen for "skipped heart beat." She works about 50 h a week, exercises at the local gym, and enjoys eating a healthy diet. Read More

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http://link.springer.com/10.1007/s11936-019-0727-2
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http://dx.doi.org/10.1007/s11936-019-0727-2DOI Listing
April 2019
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Pharmacy student professional identity formation: a scoping review.

Integr Pharm Res Pract 2019 27;8:15-34. Epub 2019 Mar 27.

School of Pharmacy, The University of Queensland, Woolloongabba, QLD, Australia,

Purpose: Transitioning from being pharmacy students to pharmacists is challenging. Students need to reconcile their professional aspirations and what they have learnt with the realities of practice. A smooth transition can be hampered when they are unable to enact the role they have envisaged or if their expectations are not met. Read More

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https://www.dovepress.com/pharmacy-student-professional-iden
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http://dx.doi.org/10.2147/IPRP.S162799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443221PMC
March 2019
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A retrospective observational analysis of red blood cell transfusion practices in stable, non-bleeding adult patients admitted to nine medical-surgical intensive care units.

J Intensive Care 2019 4;7:19. Epub 2019 Apr 4.

1Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, 3D18, Teaching Research and Wellness Building, 3280 Hospital Drive NW, Calgary, Alberta T2N 4N1 Canada.

Background: Red blood cell (RBC) transfusions are common procedures performed in the intensive care unit (ICU). However, conservative transfusion approaches have been recommended to avoid RBC transfusions that are not clinically necessary and to achieve optimal patient outcomes. The objective of this study was to examine the utilization and costs of RBC transfusions in medical-surgical ICUs and to compare this information against clinical guideline recommendations for best practice. Read More

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http://dx.doi.org/10.1186/s40560-019-0375-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449900PMC

After Hour Blood Transfusions: A Transfusion Service Perspective.

Indian J Hematol Blood Transfus 2019 Apr 1;35(2):292-296. Epub 2018 Oct 1.

Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka India.

Optimal functioning of blood transfusion service during after hours with limited resources are highly challenging. Best transfusion practice guidelines recommends to avoid non-urgent transfusions during out-of-core hours for the concern of patient's safety. This study aimed to evaluate the after hour packed red cell transfusion practice and to identify the proportion of avoidable transfusions in our center. Read More

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http://link.springer.com/10.1007/s12288-018-1015-0
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http://dx.doi.org/10.1007/s12288-018-1015-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439069PMC
April 2019
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Comparative performance of urinary biomarkers for vancomycin induced kidney injury according to timeline of injury.

Antimicrob Agents Chemother 2019 Apr 15. Epub 2019 Apr 15.

Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, USA

Urinary biomarkers are superior to serum creatinine for defining onset and extent of kidney injury. This study classifies the temporal predictive ability of biomarkers for vancomycin-induced kidney injury (VIKI) as defined by histopathologic damage.: Male Sprague-Dawley rats (n=125) were randomized to receive 150 to 400 mg/kg/day vancomycin via once or twice daily intraperitoneal injection over 1, 3, or 6 days. Read More

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http://dx.doi.org/10.1128/AAC.00079-19DOI Listing

Effect of Concomitant Disease-modifying Antirheumatic Drugs and Methotrexate Administration Route on Biologic Treatment Durability in Rheumatoid Arthritis: OBRI Cohort Results.

J Rheumatol 2019 Apr 15. Epub 2019 Apr 15.

From McMaster University, Hamilton, Ontario; Southlake Regional Health Centre, Newmarket, Ontario; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario; JSS Medical Research; McGill University, Montreal, Quebec; University of Toronto, Department of Medicine and Institute of Health Policy, Management, and Evaluation; Mount Sinai Hospital, Division of Rheumatology, Toronto, Ontario, Canada. OBRI was funded by peer-reviewed grants from Canadian Institute for Health Research (CIHR), Ontario Ministry of Health and Long-Term Care (MOHLTC), Canadian Arthritis Network (CAN), and unrestricted grants from AbbVie, Amgen, Celgene, Hospira, Janssen, Lilly, Merck, Novartis, Pfizer, Roche, Sanofi, and UCB. MM, AC, XL, SC, and CB are employees at OBRI, which was funded by peer-reviewed grants from CIHR, MOHLTC, CAN, and unrestricted grants from AbbVie, Amgen, Bristol Myers Squibb, Celgene, Hospital Janssen, Pfizer, Roche, Sanofi, and UCB. ER and JSS are employees at JSS Medical Research, a contract research organization. A.N. Lau, MD, McMaster University; J.C. Thorne, MD, Southlake Regional Health Centre; M. Movahedi, MD, PhD, Toronto General Hospital Research Institute, University Health Network; E. Rampakakis, PhD, JSS Medical Research; A. Cesta, BSc, Toronto General Hospital Research Institute, University Health Network; X. Li, BSc, Toronto General Hospital Research Institute, University Health Network; S. Couto, MSc, Toronto General Hospital Research Institute, University Health Network; J. Sampalis, PhD, JSS Medical Research, and McGill University; C. Bombardier, MD, Toronto General Hospital Research Institute, University Health Network, and University of Toronto, Department of Medicine and Institute of Health Policy, Management, and Evaluation, and Mount Sinai Hospital, Division of Rheumatology. Address correspondence to Dr. A.N. Lau, 501-25 Charlton Ave. East, Hamilton, Ontario L8N 1Y2, Canada. E-mail: Accepted for publication October 30, 2018.

Objective: Prior studies have suggested that concurrent conventional synthetic disease-modifying antirheumatic drug (csDMARD) therapy enhances the efficacy of biologic DMARD (bDMARD). Here, we assessed the effect of concomitant csDMARD use and methotrexate (MTX) route of administration on time to bDMARD discontinuation in a large Canadian (Ontario), observational, rheumatoid arthritis (RA) cohort.

Methods: Patients from the Ontario Best Practices Research Initiative (OBRI) who initiated bDMARD therapy and had ≥ 1 followup assessment were included. Read More

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http://dx.doi.org/10.3899/jrheum.180486DOI Listing

Genetic characteristics and antibiotic resistance of Haemophilus influenzae isolates from pediatric patients with acute otitis media after introduction of 13-valent pneumococcal conjugate vaccine in Japan.

J Infect Chemother 2019 Apr 12. Epub 2019 Apr 12.

Department of Infectious Diseases, National Cancer Center Hospital, Tokyo, Japan.

Acute otitis media (AOM) occurs commonly in pediatric populations. We examined resistance genotype, antibiotic susceptibility, quinolone (QL) resistance, and multilocus sequence type (MLST) among Haemophilus influenzae isolates causing AOM following introduction of pneumococcal conjugate vaccines in Japan. The AOM surveillance group included 69 participating otolaryngologists. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.03.019DOI Listing

Dialysis initiation, modality choice, access, and prescription: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney Int 2019 Apr 12. Epub 2019 Apr 12.

University of Sydney, Sydney, NSW, Australia. Electronic address:

Globally, the number of patients undergoing maintenance dialysis is increasing, yet throughout the world there is significant variability in the practice of initiating dialysis. Factors such as availability of resources, reasons for starting dialysis, timing of dialysis initiation, patient education and preparedness, dialysis modality and access, as well as varied "country-specific" factors significantly affect patient experiences and outcomes. As the burden of end-stage kidney disease (ESKD) has increased globally, there has also been a growing recognition of the importance of patient involvement in determining the goals of care and decisions regarding treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538193013
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http://dx.doi.org/10.1016/j.kint.2019.01.017DOI Listing
April 2019
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Exploring the qualities of midwifery-led continuity of care in Australia (MiLCCA) using the quality maternal and newborn care framework.

Women Birth 2019 Apr 12. Epub 2019 Apr 12.

Mother and Infant Research Unit-University of Dundee, City Campus, 11 Airlie Pl, Dundee DD1 4HJ, United Kingdom.

Problem: Midwifery-led continuity of care has well documented evidence of benefits for mothers and babies, however uptake of these models by Australian maternity services has been slow.

Background: It is estimated that only 10% of women have access to midwifery-led continuity of care in Australia. The Quality Maternal Newborn Care (QMNC) Framework has been developed as a way to implement and upscale health systems that meet the needs of childbearing women and their infants. Read More

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http://dx.doi.org/10.1016/j.wombi.2019.03.013DOI Listing

Surgical management of pediatric rectal prolapse: A survey of the American Pediatric Surgical Association (APSA).

J Pediatr Surg 2019 Mar 18. Epub 2019 Mar 18.

University of California at Davis Medical Center, Shriners Hospitals for Children, Northern California, 2425 Stockton Blvd., Sacramento, CA 25817.

Introduction: Many management options exist for the treatment of refractory rectal prolapse (RP) in children. Our goal was to characterize current practice patterns among active members of APSA.

Methods: A 23-item questionnaire assessed the management of full-thickness RP for healthy children who have failed medical management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223468193013
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http://dx.doi.org/10.1016/j.jpedsurg.2019.02.017DOI Listing
March 2019
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The trials and tribulations of conducting an m-health pilot randomized controlled trial to improve oral cancer therapy adherence: recommendations for future multisite, non-drug clinical trials.

BMC Res Notes 2019 Apr 15;12(1):226. Epub 2019 Apr 15.

Peter MacCallum Cancer Centre, Parkville, Melbourne, VIC, Australia.

Objective: Integrating mobile phone-based health (m-health) interventions into healthcare systems is one solution to improve access to services for the growing number of patients with chronic illness. Practical challenges such as poor recruitment and inadequate resource allocation can hamper the assessment of such interventions with clinical trial methodology. This paper highlights the challenges encountered during a pilot randomized controlled trial of an m-health medication adherence intervention and offers recommendations for future multi-site, non-drug clinical trials. Read More

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http://dx.doi.org/10.1186/s13104-019-4264-6DOI Listing

How are evidence generation partnerships between researchers and policy-makers enacted in practice? A qualitative interview study.

Health Res Policy Syst 2019 Apr 15;17(1):41. Epub 2019 Apr 15.

South Eastern Sydney Local Health District (SESLHD), Carringbah, Australia.

Background: Evidence generation partnerships between researchers and policy-makers are a potential method for producing more relevant research with greater potential to impact on policy and practice. Little is known about how such partnerships are enacted in practice, however, or how to increase their effectiveness. We aimed to determine why researchers and policy-makers choose to work together, how they work together, which partnership models are most common, and what the key (1) relationship-based and (2) practical components of successful research partnerships are. Read More

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http://dx.doi.org/10.1186/s12961-019-0441-2DOI Listing

Expert-led and artificial intelligence (AI) system-assisted tutoring course increase confidence of Chinese medical interns on suturing and ligature skills: prospective pilot study.

J Educ Eval Health Prof 2019 10;16. Epub 2019 Apr 10.

Office of Medical Education, University of New South Wales Australia, Sydney, Australia.

Purpose: Lack of confidence in suturing/ligature skills due to insufficient practices and assessments was common among novice Chinese medical interns. This study aims to improve the skill acquisition of medical interns with new interventional program.

Methods: In addition to regular clinical training, additional expert-led or expert-led plus artificial intelligent (AI) system tutoring courses were implemented during the first 2 week of surgical block in our hospital. Read More

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http://www.jeehp.org/DOIx.php?id=10.3352/jeehp.2019.16.7
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http://dx.doi.org/10.3352/jeehp.2019.16.7DOI Listing
April 2019
2 Reads

A Structured, Debate-Style Cardiothoracic Surgery Journal Club for Trainee Acquisition and Application of Seminal Literature.

MedEdPORTAL 2016 Dec 23;12:10521. Epub 2016 Dec 23.

Thoracic Surgeon, University of Texas MD Anderson Cancer Center.

Introduction: The acquisition of specialty-specific seminal literature and its application to daily, clinical patient-care decisions are critical components of clinical training. This structured, debate-style cardiothoracic surgery journal club module engages trainees in discussion of realistic patient scenarios, incorporating an extensive body of literature identified as the best evidence for the practice of cardiothoracic surgery.

Methods: We designed the structured, debate-style cardiothoracic surgery journal club and delivered it to University of Texas MD Anderson Cancer Center cardiothoracic surgery trainees. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440406PMC
December 2016

Engaging Learners Through Modules in Quality Improvement and Patient Safety.

MedEdPORTAL 2016 Oct 13;12:10482. Epub 2016 Oct 13.

Assistant Professor and Hospitalist, Departments of Pediatrics, Baylor College of Medicine.

Introduction: Residents are on the front lines of medical care in academic institutions. Their daily interactions are crucial to the quality of care received by patients in these settings, and thus, knowledge of patient safety and quality improvement is essential. The Accreditation Council for Graduate Medical Education requires all residents to participate in quality improvement and patient safety programs as part of their residency training. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440404PMC
October 2016

Surveillance for HCC: Current Best Practice and Future Direction.

Gastroenterology 2019 Apr 12. Epub 2019 Apr 12.

Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX.

Hepatocellular cancer (HCC) is the 4 leading cause of cancer-related death worldwide and the fastest growing cause of cancer deaths in the U.S. The overall prognosis of HCC remains dismal except for the subset of patients who are diagnosed at early stage and receive potentially curative therapies such as surgical resection and liver transplantation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193569
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http://dx.doi.org/10.1053/j.gastro.2019.02.049DOI Listing
April 2019
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The Current State of Advanced Practice Provider Fellowships in Hospital Medicine: A Survey of Program Directors.

J Hosp Med 2019 Apr 8;14:E1-E6. Epub 2019 Apr 8.

Division of Hospital Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland.

Background: Postgraduate training for advanced practice providers (APPs) is a growing field in hospital medicine. As hospital programs continue to benefit from highly trained physician assistants (PAs) and nurse practitioners (NPs), fellowship programs have become more prevalent. However, little is known about the number of active programs or how they prepare trainees. Read More

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http://dx.doi.org/10.12788/jhm.3191DOI Listing
April 2019
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Evidence-Based Practice Guideline: Assessing Heart Failure in Long-Term Care Facilities.

J Gerontol Nurs 2019 Apr 12:1-7. Epub 2019 Apr 12.

Evidence suggests the most crucial elements to successful heart failure (HF) management in long-term care (LTC) include improving staffs' HF knowledge to recognize and intervene in early symptom exacerbations, embedding an effective and integrated interprofessional communication system into daily care processes, risk stratification, and anticipatory advanced care planning. Despite a large body of evidence describing best practices, quality HF management remains elusive in LTC facilities. Studies have shown that care quality and outcomes improve when the entire team, including direct caregivers, have an active role in residents' care planning and implementation. Read More

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https://www.healio.com/doiresolver?doi=10.3928/00989134-2019
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http://dx.doi.org/10.3928/00989134-20190409-01DOI Listing
April 2019
4 Reads