176,841 results match your criteria Best practice & research. Clinical endocrinology & metabolism[Journal]


Machine Learning in Aging: An Example of Developing Prediction Models for Serious Fall Injury in Older Adults.

J Gerontol A Biol Sci Med Sci 2020 Jun 4. Epub 2020 Jun 4.

Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC.

Background: Advances in computational algorithms and the availability of large datasets with clinically relevant characteristics provide an opportunity to develop machine learning prediction models to aid in diagnosis, prognosis, and treatment of older adults. Some studies have employed machine learning methods for prediction modeling, but skepticism of these methods remains due to lack of reproducibility and difficulty understanding the complex algorithms that underlie models. We aim to provide an overview of two common machine learning methods: decision tree and random forest. Read More

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http://dx.doi.org/10.1093/gerona/glaa138DOI Listing

"We Just Never Have Enough Time": Clinician Views of Lung Cancer Screening Processes and Implementation.

Ann Am Thorac Soc 2020 Jun 4. Epub 2020 Jun 4.

VA Portland Health Care System, Section of Pulmonary and Critical Care Medicine, Portland, Oregon, United States.

Rationale: Despite a known mortality benefit, lung cancer screening (LCS) implementation has been unexpectedly slow. New programs face barriers to implementation, which may include lack of clinician engagement or beliefs that the intervention is not beneficial.

Objective: To evaluate diverse clinician perspectives on their views of LCS and their experience with LCS implementation and processes. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202003-262OCDOI Listing

Patient and Family Member Experiences in Critical Care Research and Quality Improvement Projects.

Nurs Res 2020 Jun 1. Epub 2020 Jun 1.

London South Bank University/Royal National Orthopaedic Hospital, London, England Kingston and St. Georges Faculty of Health, Social Care and Education, London, England Kingston and St. Georges Faculty of Health, Social Care and Education, London, England.

Background: Public and patient involvement in healthcare research is increasing, but the effect of involvement on individuals, service delivery, and health outcomes-particularly in specialist population groups like critical care-remains unclear, as does the best way to involve people who have experienced critical illness.

Objectives: To explore former patients' and family members' views and experiences of involvement in critical care research and/or quality improvement.

Methods: Using a qualitative methodology, semistructured telephone interviews were conducted with seven former intensive care unit patients and three close family members across England. Read More

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http://dx.doi.org/10.1097/NNR.0000000000000443DOI Listing

OCRIPLASMIN FOR VITREOMACULAR TRACTION IN CLINICAL PRACTICE: The INJECT Study.

Retina 2020 Jun 2. Epub 2020 Jun 2.

Oxurion NV, Leuven, Belgium.

Purpose: Randomized clinical trials have demonstrated the safety and efficacy of ocriplasmin in patients with vitreomacular traction (VMT), including those with macular hole (MH). The INJECT study prospectively evaluated ocriplasmin in the setting of clinical practice.

Methods: INJECT was a Phase 4, multicenter, prospective observational study. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002862DOI Listing

Practice Modification for Pandemics: A Model for Surge Planning in Obstetrics.

Obstet Gynecol 2020 Jun 2. Epub 2020 Jun 2.

Departments of Obstetrics and Gynecology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Obstetrics and Gynecology, University of Rochester, Rochester, New York; and the Department of Obstetrics and Gynecology, University of California at Los Angeles, and the Center for Fetal Medicine and Women's Ultrasound, Los Angeles, California.

This review highlights proposed pandemic-adjusted modifications in obstetric care, with discussion of risks and benefits based on available evidence. We suggest best practices for balancing community-mitigation efforts with appropriate care of obstetric patients. Read More

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http://dx.doi.org/10.1097/AOG.0000000000004004DOI Listing

Endometrioma surgery is associated with increased risk of subsequent assisted reproductive technology cycle cancellation; a retrospective cohort study.

J Obstet Gynaecol 2020 Jun 4:1-4. Epub 2020 Jun 4.

Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey.

The aim of this study was to assess the effect of laparoscopic removal of endometrioma on assisted reproductive technology (ART) outcome. A retrospective cohort study was conducted at a university hospital between January 2014 and December 2017. The ART group consisted of 26 women who underwent 44 ART cycles in the presence of ovarian endometrioma and the surgery group consisted of 53 women who underwent 58 ART cycles after laparoscopic removal of ovarian endometrioma/s. Read More

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http://dx.doi.org/10.1080/01443615.2020.1754366DOI Listing

The Role of Wearables in Heart Failure.

Curr Heart Fail Rep 2020 Jun 3. Epub 2020 Jun 3.

Royal Brompton Hospital, London, UK.

Purpose Of Review: This review discusses how wearable devices-sensors externally applied to the body to measure a physiological signal-can be used in heart failure (HF) care.

Recent Findings: Most wearables are marketed to consumers and can measure movement, heart rate, and blood pressure; detect and monitor arrhythmia; and support exercise training and rehabilitation. Wearable devices targeted at healthcare professionals include ECG patch recorders and vests, patches, and textiles with in-built sensors for improved prognostication and the early detection of acute decompensation. Read More

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http://dx.doi.org/10.1007/s11897-020-00467-xDOI Listing

Current Molecular Targeted Agents for Advanced Gastric Cancer.

Onco Targets Ther 2020 12;13:4075-4088. Epub 2020 May 12.

Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.

Gastric cancer is the third leading cause of malignant tumor-related mortality worldwide. Traditional cytotoxic agents prolong the overall survival and progression-free survival of patients with advanced gastric cancer (AGC) compared to that with best supportive care. Due to the occurrence of serious adverse drug reactions that result in discontinued treatment, the survival benefit in AGC remains unsatisfactory. Read More

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http://dx.doi.org/10.2147/OTT.S246412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229784PMC

An educational pathway and teaching materials for first aid training of children in sub-Saharan Africa based on the best available evidence.

BMC Public Health 2020 Jun 3;20(1):836. Epub 2020 Jun 3.

Division of Emergency Medicine, Stellenbosch University, Cape Town, South Africa.

Background: First aid training is a cost-effective way to decrease the burden of disease and injury in low- and middle-income countries (LMIC). Since evidence from Western countries has shown that children are able to learn first aid, first aid training of children in LMIC may be a promising way forward. Hence, our project aim was to develop contextualized materials to train sub-Saharan African children in first aid, based on the best available evidence. Read More

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http://dx.doi.org/10.1186/s12889-020-08857-5DOI Listing

A retrospective study of patient-tailored FOLFIRINOX as a first-line chemotherapy for patients with advanced biliary tract cancer.

BMC Cancer 2020 Jun 3;20(1):515. Epub 2020 Jun 3.

INSERM U935 Campus CNRS, Villejuif, France.

Background: FOLFIRINOX is a pillar first-line regimen in the treatment of pancreatic cancer. Historically, biliary tract cancer (BTC) and pancreatic cancer have been treated similarly with gemcitabine alone or combined with a platinum compound. With growing evidence supporting the role of fluoropyrimidines in the treatment of BTC, we aimed at assessing the outcomes of patients (pts) with BTC on frontline FOLFIRINOX. Read More

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http://dx.doi.org/10.1186/s12885-020-07004-yDOI Listing

No one accelerometer-based physical activity data collection protocol can fit all research questions.

BMC Med Res Methodol 2020 Jun 3;20(1):141. Epub 2020 Jun 3.

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Alfred Nobels Allé 23, 141 83, Huddinge, Sweden.

Background: Measuring physical activity and sedentary behavior accurately remains a challenge. When describing the uncertainty of mean values or when making group comparisons, minimising Standard Error of the Mean (SEM) is important. The sample size and the number of repeated observations within each subject influence the size of the SEM. Read More

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http://dx.doi.org/10.1186/s12874-020-01026-7DOI Listing

The use of a mobile educational tool on pressure injury education for individuals living with spinal cord injury/disease: a qualitative research study.

Disabil Rehabil 2020 Jun 4:1-10. Epub 2020 Jun 4.

Department of Physical Therapy, University of Toronto, Toronto, Canada.

As many as 30-60% of individuals living with spinal cord injury/disease (SCI/D) experience at least one pressure injury (PI) in their lifetime. Best practice guidelines in SCI/D rehabilitation emphasize the importance of providing education regarding PI prevention and management for individuals living with SCI/D. Mobile educational applications can be used for PI education however there is limited research on the user-experiences of mobile educational applications about PIs for individuals living with SCI/D. Read More

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http://dx.doi.org/10.1080/09638288.2020.1771780DOI Listing

Pharmacist-Pharmacy Technician Intraprofessional Collaboration and Workplace Integration: Implications for Educators.

Pharmacy (Basel) 2020 Jun 1;8(2). Epub 2020 Jun 1.

Leslie Dan Faculty of Pharmacy and the Institute for Health Policy, Management, and Evaluation-Faculty of Medicine, University of Toronto, Toronto, ON M5S 3M2, Canada.

Globally, concerns have been expressed regarding the impact of regulation of pharmacy technicians. After more than a decade of experience with technician regulation in Ontario, Canada, uptake of the full scope of practice for technicians has been sporadic at best. The objective of this study was to examine barriers and facilitators to intraprofessional collaboration between pharmacists and pharmacy technicians for the purpose of identifying possible curricular or educational interventions to enhance workplace integration. Read More

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http://dx.doi.org/10.3390/pharmacy8020095DOI Listing

COVID-19 and the eye: how much do we really know? A best evidence review.

Arq Bras Oftalmol 2020 Jun 29;83(3):250-261. Epub 2020 May 29.

Centro Mexicano de Salud Visual Preventiva, Mexico City, Mexico.

To identify and classify available information regarding COVID-19 and eye care according to the level of evidence, within four main topics of interest: evidence of the virus in tears and the ocular surface, infection via the conjunctival route, ocular manifestations, and best practice recommendations. A structured review was conducted in PubMed, ScienceDirect, LILACS, SciELO, the Cochrane Library and Google Scholar on COVID-19 and ophthalmology. The Oxford Centre for Evidence Based Medicine 2011 Levels of Evidence worksheet was used for quality assessments. Read More

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http://dx.doi.org/10.5935/0004-2749.20200067DOI Listing

Assigning mentors for new HSC faculty hires: A preliminary policy evaluation.

Chron Mentor Coach 2019 Oct;3(Spec Iss 12):427-432

University of New Mexico School of Medicine; University of New Mexico College of Nursing.

Effective practices for selecting mentors for new faculty at academic health centers (AHC) are currently unknown. The University of New Mexico's School of Medicine assigns a mentor to all new faculty at the time of hire. The effectiveness of this policy measure has not been previously evaluated. Read More

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October 2019

Ethical issues in poultry production - Datasets from a German consumer survey.

Data Brief 2020 Aug 20;31:105748. Epub 2020 May 20.

Leibniz Centre for Agricultural Landscape Research (ZALF), Eberswalder Strasse 84, 15374 Muencheberg, Germany.

The killing of day-old chicks is controversially discussed in poultry keeping, science, politics, and society. The present survey data contributes to understand consumers´ attitudes towards ethical issues in chicken production, especially the killing practice and dual purpose chickens as alternative to avoid such killing. Information on the various topics is provided: Consumer purchase pattern of eggs and chicken meat, perception of animal welfare and protection issues, knowledge and perception of killing day-old chicks, attitudes towards dual purpose chickens as an alternative to killing day-old chicks, and socio-demographic data. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256461PMC

Microsurgical reconstruction affects the outcome in a translational mouse model for Achilles tendon healing.

J Orthop Translat 2020 Sep 11;24:1-11. Epub 2020 May 11.

Department of Regenerative Musculoskeletal Medicine, Institute of Musculoskeletal Medicine, Westfaelische Wilhelms University Muenster, Muenster, Germany.

Background: Animal models are one of the first steps in translation of basic science findings to clinical practice. For tendon healing research, transgenic mouse models are important to advance therapeutic strategies. However, the small size of the structures complicates surgical approaches, histological assessment, and biomechanical testing. Read More

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http://dx.doi.org/10.1016/j.jot.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260609PMC
September 2020

A digital decision support system (selfBACK) for improved self-management of low back pain: a pilot study with 6-week follow-up.

Pilot Feasibility Stud 2020 23;6:72. Epub 2020 May 23.

Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Background: Very few of the publicly available apps directed towards self-management of low back pain (LBP) have been rigorously tested and their theoretical underpinnings seldom described. The selfBACK app was developed in collaboration with end-users and clinicians and its content is supported by best evidence on self-management of LBP. The objectives of this pilot study were to investigate the basis for recruitment and screening procedures for the subsequent randomized controlled trial (RCT), to test the inclusion process in relation to questionnaires and app installation, and finally to investigate the change in primary outcome over time. Read More

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http://dx.doi.org/10.1186/s40814-020-00604-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245029PMC

Baseline staging imaging for distant metastasis in women with stages I, II, and III breast cancer.

Curr Oncol 2020 Apr 1;27(2):e123-e145. Epub 2020 May 1.

Division of Medical Oncology, Sunnybrook Health Sciences Centre, Toronto, ON.

Background: In Ontario, there is no clearly defined standard of care for staging for distant metastasis in women with newly diagnosed and biopsy-confirmed breast cancer whose clinical presentation is suggestive of early-stage disease. This guideline addresses baseline imaging investigations for women with newly diagnosed primary breast cancer who are otherwise asymptomatic for distant metastasis.

Methods: The medline and embase databases were systematically searched for evidence from January 2000 to April 2019, and the best available evidence was used to draft recommendations relevant to the use of baseline imaging investigation in women with newly diagnosed primary breast cancer who are otherwise asymptomatic. Read More

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http://dx.doi.org/10.3747/co.27.6147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253735PMC

Incorporating preauthorization into antimicrobial stewardship pharmacist workflow reduces and gastrointestinal panel testing.

Infect Control Hosp Epidemiol 2020 Jun 3:1-6. Epub 2020 Jun 3.

Department of Pharmacy, University of Michigan, Ann Arbor, Michigan.

Objective: To evaluate whether incorporating mandatory prior authorization for Clostridioides difficile testing into antimicrobial stewardship pharmacist workflow could reduce testing in patients with alternative etiologies for diarrhea.

Design: Single center, quasi-experimental before-and-after study.

Setting: Tertiary-care, academic medical center in Ann Arbor, Michigan. Read More

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http://dx.doi.org/10.1017/ice.2020.236DOI Listing

Augmented and Virtual Reality in Anatomical Education - A Systematic Review.

Adv Exp Med Biol 2020 ;1235:89-101

Anatomy Facility, School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Learning anatomy traditionally has depended on traditional techniques like human cadaveric dissection and the use of textbooks. As technology advances at an ever-rapid speed, there are revolutionary ways to learn anatomy. A number of technologies, techniques and methodologies are utilised in anatomical education, but ones specifically receiving a lot of interest and traction is that of augmented reality and virtual reality. Read More

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http://dx.doi.org/10.1007/978-3-030-37639-0_5DOI Listing
January 2020

Ultrasound-Guided Regional Anaesthesia: Visualising the Nerve and Needle.

Adv Exp Med Biol 2020 ;1235:19-34

NHS Tayside, Dundee, Scotland, UK.

Regional anaesthesia involves targeting specific peripheral nerves with local anaesthetic. It facilitates the delivery of anaesthesia and analgesia to an increasingly complex, elderly and co-morbid patient population. Regional anaesthesia practice has been transformed by the use of ultrasound, which confers advantages such as accuracy of needle placement, visualisation of local anaesthetic spread, avoidance of intraneural injection and the ability to accommodate for anatomical variation. Read More

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http://dx.doi.org/10.1007/978-3-030-37639-0_2DOI Listing
January 2020

Can the provision of sexual healthcare for oncology patients be improved? A literature review of educational interventions for healthcare professionals.

J Cancer Surviv 2020 Jun 1. Epub 2020 Jun 1.

Department of Urology, Leiden University Medical Centre, PO-box 9600, 2300 WB, Leiden, The Netherlands.

Purpose: Sexual health is an important quality-of-life concern for cancer patients and survivors, but a difficult discussion topic for patients and healthcare professionals. The most important barriers causing healthcare professionals to avoid the topic are lack of education and lack of knowledge. How effective education about sexual health is for oncology healthcare professionals is not clear. Read More

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http://dx.doi.org/10.1007/s11764-020-00898-4DOI Listing

Clinical trials of acute mechanical circulatory support in cardiogenic shock and high-risk percutaneous coronary intervention.

Curr Opin Cardiol 2020 Jul;35(4):332-340

The Cardiovascular Center for Research and Innovation, Tufts Medical Center, Boston, Massachusetts, USA.

Purpose Of Review: Acute mechanical circulatory support devices have become widely used in cardiogenic shock and high-risk percutaneous coronary intervention (PCI) but there remains significant controversy over the evidence supporting their use and the specific roles of various devices. In this review, we summarize major recent studies and identify key areas of future investigation.

Recent Findings: In cardiogenic shock, uncontrolled single arm studies emphasizing early mechanical circulatory support (MCS) have showed promising results, but randomized trials have either been stopped prematurely or enrolled patients with advanced shock unlikely to benefit from MCS. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000751DOI Listing

New Graduate Orientation Evaluation: Are There Any Best Practices Out There?: A Scoping Review.

J Nurses Prof Dev 2020 Jun 1. Epub 2020 Jun 1.

Jennifer Laflamme, MSN, RN-BC, CHFN, is Research Assistant (Pre-Diem), Center for Nursing Research and Quality Outcomes, Maine Medical Center, Portland. Kristiina Hyrkas, PhD, LicNSc, MNSc, RN, is Director, Center for Nursing Research and Quality Outcomes, Maine Medical Center, and Adjunct Professor, University of Southern Maine, Portland.

Efficient, cost-effective, and safe orientations with clear expectations are necessary for new graduates in their transition from student to practicing nurse. In the current nursing shortage, healthcare needs to invest more in retaining new graduates. Orientation can be a factor in decisions to leave. Read More

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http://dx.doi.org/10.1097/NND.0000000000000642DOI Listing

Helping Unlock Better Care (HUB|C) using quality improvement science in community pharmacies - An implementation method.

Res Social Adm Pharm 2020 May 16. Epub 2020 May 16.

University of Waterloo School of Pharmacy, 10A Victoria St S, Kitchener, ON, N2G 1C5, Canada; OPEN, Ontario Pharmacy Evidence Network, Canada. Electronic address:

Introduction: Community pharmacists' optimal scope of practice extends far beyond traditional dispensing or compounding, and health promotion or chronic disease management services based in the pharmacy can generate significant social and economic value. But, with many competing demands and performance expectations from patients, payers, and policymakers, many pharmacies face challenges when introducing, maintaining, optimizing, or integrating their service offerings. Quality Improvement (QI) science may provide a practical change management framework for pharmacy professionals to lead their teams in embracing optimal scope and in making pharmacy-based services more feasible and attractive for all parties. Read More

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http://dx.doi.org/10.1016/j.sapharm.2020.05.006DOI Listing

Duration of antibiotic therapy in critically ill patients: a randomized controlled trial of a clinical and C-reactive protein-based protocol versus an evidence-based best practice strategy without biomarkers.

Crit Care 2020 Jun 1;24(1):281. Epub 2020 Jun 1.

Graduate Program in Health Sciences: Infectious Diseases and Tropical Medicine, Department of Internal Medicine, School of Medicine and Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Background: The rational use of antibiotics is one of the main strategies to limit the development of bacterial resistance. We therefore sought to evaluate the effectiveness of a C-reactive protein-based protocol in reducing antibiotic treatment time in critically ill patients.

Methods: A randomized, open-label, controlled clinical trial conducted in two intensive care units of a university hospital in Brazil. Read More

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http://dx.doi.org/10.1186/s13054-020-02946-yDOI Listing

After initial invigoration by heading, young pear trees show reduction in axis vigour and increased propensity to flower.

Funct Plant Biol 2012 Feb;40(1):34-43

The New Zealand Institute for Plant and Food Research Limited, Hawke's Bay Research Centre, Private Bag 1401, Havelock North, New Zealand.

Fast establishment of the canopy in young trees, followed by reduced vegetative vigour and precocity are desirable traits in fruit production. Severe heading (cutting back the primary axis of the tree after the first year of growth) to induce branching is a nursery practice to increase early fruit yield. Our aim was to provide a systematic study of the responses of young pear trees to severe heading. Read More

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http://dx.doi.org/10.1071/FP12164DOI Listing
February 2012

The development an artificial intelligence algorithm for early sepsis diagnosis in the intensive care unit.

Int J Med Inform 2020 May 21;141:104176. Epub 2020 May 21.

Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Background: Severe sepsis and septic shock are still the leading causes of death in Intensive Care Units (ICUs), and timely diagnosis is crucial for treatment outcomes. The progression of electronic medical records (EMR) offers the possibility of storing a large quantity of clinical data that can facilitate the development of artificial intelligence (AI) in medicine. However, several difficulties, such as poor structure and heterogenicity of the raw EMR data, are encountered when introducing AI with ICU data. Read More

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http://dx.doi.org/10.1016/j.ijmedinf.2020.104176DOI Listing

Knowledge vs. know-how? Dissecting the foundations of stone knapping skill.

J Hum Evol 2020 May 30;145:102807. Epub 2020 May 30.

Department of Anthropology, Emory University, Atlanta, GA, USA.

Stone tools provide some of the best remaining evidence of behavioral change over long periods, but their cognitive and evolutionary implications remain poorly understood. Here, we contribute to a growing body of experimental research on the cognitive and perceptual-motor foundations of stone toolmaking skills by using a flake prediction paradigm to assess the relative importance of technological understanding vs. accurate action execution in Late Acheulean-style handaxe production. Read More

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http://dx.doi.org/10.1016/j.jhevol.2020.102807DOI Listing

Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT.

Health Technol Assess 2020 May;24(25):1-150

School of Health Sciences, Bangor University, Bangor, UK.

Background: Most people who are dying want to be cared for at home, but only half of them achieve this. The likelihood of a home death often depends on the availability of able and willing lay carers. When people who are dying are unable to take oral medication, injectable medication is used. Read More

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http://dx.doi.org/10.3310/hta24250DOI Listing

Role of Policy in Best-Practice Dissemination: Informal Professional Advice Networks in Canadian Long-Term Care.

Can J Aging 2020 Jun 2:1-11. Epub 2020 Jun 2.

Faculty of Nursing, University of Alberta.

This article examines provincial policy influence on long-term care (LTC) professionals' advice-seeking networks in Canada's Maritime provinces. The effects of facility ownership, geography, and region-specific political landscapes on LTC best-practice dissemination are examined. We used sociometric statistics and network sociograms, calculated from surveys with 169 senior leaders in LTC facilities, to identify advice-seeking network structures and to select 11 follow-up interview participants. Read More

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http://dx.doi.org/10.1017/S0714980820000057DOI Listing

Social participation and loneliness among older adults in Yazd, Iran.

Health Soc Care Community 2020 Jun 1. Epub 2020 Jun 1.

Department of Aging Health, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Social participation among older people is associated with more practice of physical activities, improvement of cognitive skills and less feeling of loneliness. The primary purpose of this cross-sectional study was to examine the social participation and sense of loneliness among older adults in Yazd, an Iranian city that is known for its traditional values and religious people. The non-probability sample consisted of 200 elderly people. Read More

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http://dx.doi.org/10.1111/hsc.13018DOI Listing

The association between frailty and detrusor overactivity in older adults.

Neurourol Urodyn 2020 Jun 1. Epub 2020 Jun 1.

Department of Urology, University of California-San Francisco, San Francisco, California.

Objective: To explore the relationship between frailty, age, and detrusor overactivity (DO) in older adults presenting to an academic urology practice.

Materials And Methods: This study uses the University of California, San Francisco Geriatric Urology Database to examine all adults ages ≥65 years who underwent urodynamic testing from December 2015 to April 2019. All subjects had a timed up and go test (TUGT) as a measure of frailty and were categorized as fast (≤10 seconds), intermediate (11-14 seconds), or slow (≥15 seconds), corresponding to not frail, pre-frail, and frail, respectively. Read More

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http://dx.doi.org/10.1002/nau.24414DOI Listing

Clinical practice guidelines adaptation for internists - An EFIM methodology.

Eur J Intern Med 2020 May 29. Epub 2020 May 29.

CIBERESP-IBIS-ROCIO-University Hospital; Fundación Enebro, Seville, Spain. Electronic address:

The rising number of clinical guidelines poses a new challenge to the internists. The main problems are: 1) available documents suffer from heterogeneous methodological quality, and 2) most of clinical guidelines target an 'ideal' patient affected by a single condition, while in real practice internists must face with comorbid patients typically undergoing a polypharmacy. To help address this challenge, EFIM Clinical Practice Working Group started a project aimed to answer a series of relevant clinical questions, by selecting the best available guidance containing recommendations applicable to complex patients under polypharmacy. Read More

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http://dx.doi.org/10.1016/j.ejim.2020.05.016DOI Listing

Understanding Respiratory Rate Assessment by Emergency Nurses: A Health Care Improvement Project.

J Emerg Nurs 2020 May 29. Epub 2020 May 29.

Introduction: Respiratory rate is the first sign of patient decline. Monitoring and recording respiratory rate are essential nursing competencies. However, health care system emergency nurses' ability to differentiate normal from abnormal respiratory rates was unknown. Read More

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http://dx.doi.org/10.1016/j.jen.2020.03.012DOI Listing

A compass for care: Evaluating first-year pharmacy students' philosophy of practice.

Curr Pharm Teach Learn 2020 Jun 19;12(6):656-662. Epub 2020 Feb 19.

Department of Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota College of Pharmacy, 211 Life Science, 1110 Kirby Dr, Duluth, MN 55812, United States. Electronic address:

Introduction: A philosophy of practice serves as the foundation for any patient care practice. Understanding the philosophies of practice held by students entering the profession is important as this presents potential opportunities for educators to help shape students' professional values/beliefs. The objective of this work was to evaluate how first-year pharmacy students (P1s) conceptualize their philosophy of practice as future pharmacists. Read More

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http://dx.doi.org/10.1016/j.cptl.2020.01.035DOI Listing

Otolaryngology in the Time of Corona: Assessing Operative Impact and Risk During the COVID-19 Crisis.

Otolaryngol Head Neck Surg 2020 Jun 2:194599820930214. Epub 2020 Jun 2.

Department of Otolaryngology-Head and Neck Surgery, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Objective: Limited research exists on the coronavirus disease 2019 (COVID-19) pandemic pertaining to otolaryngology-head and neck surgery (OHNS). The present study seeks to understand the response of OHNS workflows in the context of policy changes and to contribute to developing preparatory guidelines for perioperative management in OHNS.

Study Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1177/0194599820930214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267742PMC

Lung transplantation for pulmonary sarcoidosis.

Authors:
Meyer Keith C

Sarcoidosis Vasc Diffuse Lung Dis 2019 1;36(2):92-107. Epub 2019 May 1.

Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.

Although relatively few patients with pulmonary sarcoidosis develop advanced disease that progresses to respiratory insufficiency despite receiving best practice pharmacologic interventions, lung transplantation may be the only therapeutic option for such patients to both prolong survival and provide improved quality of life. Lung transplant can be successfully performed for patients with end-stage pulmonary sarcoidosis, and post-transplant survival is similar to that for other transplant indications such as idiopathic pulmonary fibrosis. However, appropriate timing of referral, comprehensive assessment of potential candidates for lung transplant, placement of patients on the lung transplant waiting list when within the transplant window as appropriate, choosing the best procedure (bilateral versus single lung transplant), and optimal peri-operative and post-transplant management are key to successful lung transplant outcomes for patients with sarcoidosis. Read More

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http://dx.doi.org/10.36141/svdld.v36i2.7163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247104PMC

Identification of European-wide clinical priorities for guideline development in the management of pre-invasive cervical disease.

Eur J Obstet Gynecol Reprod Biol 2020 May 19;251:36-41. Epub 2020 May 19.

Department of Gynaecological Oncology, University Hospitals of North Midlands, Newcastle Road, Stoke on Trent, ST4 6QG, UK. Electronic address:

Objective: Addressing management controversies in the treatment of pre-invasive cervical disease is a key priority for the European Federation for Colposcopy/European Society of Gynaecologic Oncology who aim to develop a practical handbook of European centred guidelines to address areas where there is a lack of high-quality evidence or identifiable practice variation. Clinical opinion across the EFC network was sought to identify topics likely to have the most impact on clinical practice for systematic review and development of practice recommendations.

Study Design: A scoping exercise comprising of a three-iteration modified Delphi with representation from each member society of the EFC was conducted in 2018. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.017DOI Listing

Umbilical cord-derived mesenchymal stem cells in neurodegenerative disorders: from literature to clinical practice.

Regen Med 2020 Jun 1. Epub 2020 Jun 1.

Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran 14177-44361, Iran.

Mesenchymal stem cells (MSCs) have provided a promising tool for cell therapy. Umbilical cord (UC) is one of the best sources of MSCs since its collection is noninvasive, and effortless, and the cells from this source are more capable and prolific. It has been proven that the differentiation, migration and protective properties of UC-MSCs are superior compared with other kinds of stem cells. Read More

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http://dx.doi.org/10.2217/rme-2019-0119DOI Listing

Getting Value From Electronic Health Records: Research Needed to Improve Practice.

Ann Intern Med 2020 Jun;172(11_Supplement):S130-S136

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (D.W.B.).

Electronic health records (EHRs) are now widely adopted in the United States, but health systems have barely begun using them to deliver high-value care. More directed and rigorous research is needed to fulfill the promise of EHRs to not only store information but also support the delivery of better care. This article describes 4 potential benefits of EHR-based research: improving clinical decisions, supporting triage decisions, enabling collaboration among the care team (including patients), and increasing productivity via automation of tasks. Read More

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http://dx.doi.org/10.7326/M19-0878DOI Listing

Using Electronic Health Record Portals to Improve Patient Engagement: Research Priorities and Best Practices.

Ann Intern Med 2020 Jun;172(11_Supplement):S123-S129

UCSF Department of Medicine, Center for Vulnerable Populations at Zuckerberg San Francisco General Hospital, San Francisco, California (C.R.L., A.G.C., U.S.).

Ninety percent of health care systems now offer patient portals to access electronic health records (EHRs) in the United States, but only 15% to 30% of patients use these platforms. Using PubMed, the authors identified 53 studies published from September 2013 to June 2019 that informed best practices and priorities for future research on patient engagement with EHR data through patient portals, These studies mostly involved outpatient settings and fell into 3 major categories: interventions to increase use of patient portals, usability testing of portal interfaces, and documentation of patient and clinician barriers to portal use. Interventions that used one-on-one patient training were associated with the highest portal use. Read More

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http://dx.doi.org/10.7326/M19-0876DOI Listing

Understanding Mississippi's Current Practices Concerning Autism Screening at 18 & 24 Months.

Soc Work Public Health 2020 Jun 1:1-15. Epub 2020 Jun 1.

University of North Carolina at Chapel Hill Medical School , Chapel Hill, North Carolina, USA.

Best practice recommendations by the American Academy of Pediatrics support routine screening for developmental delays in early childhood, specifically at 18 and 24 months for Autism Spectrum Disorder (ASD). During this critical developmental period, early identification and intervention are associated with best outcomes for ASD. Pediatricians perform a critical role in the early recognition of ASD, which can co-exist with other disorders further complicating the diagnosis. Read More

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http://dx.doi.org/10.1080/19371918.2020.1764431DOI Listing

Application of Oleanolic Acid and Its Analogues in Combating Pathogenic Bacteria / by a Two-Pronged Strategy of β-Lactamases and Hemolysins.

ACS Omega 2020 May 12;5(20):11424-11438. Epub 2020 May 12.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun 130062, China.

The rapid spread of β-lactamase-producing bacteria in clinical practice has increasingly deteriorated the performance of β-lactam antibiotics against such resistant strains. Thus, novel agents or strategies for the war against β-lactamase-producing bacteria, especially hypervirulent resistant bacteria (such as toxin-secreting ) carrying complex β-lactamases, are urgently needed. In this study, we found that the natural compound oleanolic acid (OA) and its analogues (especially corosolic acid (CA)) significantly inhibited the activity of important β-lactamases (NDM-1, KPC-2, and VIM-1) in Enterobacteriaceae and β-lactamases (β-lactamase N1) in . Read More

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http://dx.doi.org/10.1021/acsomega.0c00460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254530PMC

The Transformative Influence of La Varenne's (1651) on French Culinary Practice.

Authors:
Leon G Fine

Front Nutr 2020 28;7:42. Epub 2020 Apr 28.

Program in the History of Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

The current proliferation of modern cookbooks targeted to the public at large makes it impossible to conceive of there being any that could have had an overriding influence on culinary practice or eating preferences, even at a local level. However, when there was a historical absence of cookbooks for a half-century, as there was in France in the first half of the seventeenth century, it is argued herein that the advent of a single cookbook in 1651, by La Varenne, could have had a transformational influence on culinary practice over the ensuing half-century. The book went into more than 50 subsequent editions in the second half of the century. Read More

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http://dx.doi.org/10.3389/fnut.2020.00042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198804PMC

Washout Period for Pregnancy Post Isotretinoin Therapy.

Indian Dermatol Online J 2020 Mar-Apr;11(2):239-242. Epub 2020 Mar 9.

Dermatology, Venereology and Leprosy, The Venkat Center for Skin and Plastic Surgery - Post Graduate Training Center (Affiliated to RGUHS), Subbanna Garden, Bengaluru, Karnataka, India.

Introduction And Background: Isotretinoin is an oral medication used for the treatment of severe acne unresponsive to other medications. This drug is teratogenic and should be prescribed with appropriate caution in selected group of patients. The washout period for pregnancy post isotrenoin therapy has always been a topic of controversy. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_101_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247620PMC