492,649 results match your criteria Best Practice & Research: Clinical Obstetrics & Gynaecology[Journal]


Gliquidone Alleviates Diabetic Nephropathy by Inhibiting Notch/Snail Signaling Pathway.

Cell Physiol Biochem 2018 Dec 6;51(5):2085-2097. Epub 2018 Dec 6.

Background/aims: Diabetic nephropathy is a common complication of diabetes. This study explored the renal protective effect and possible mechanism of gliquidone in mice with diabetic nephropathy.

Methods: Animal model of diabetic nephropathy was established in KKAy mice. Read More

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December 2018
2 Reads

Getting "Stuck" in the Future or the Past: Relationships between Dimensions of Time Perspective, Executive Functions, and Repetitive Negative Thinking in Anxiety.

Psychopathology 2018 Dec 6:1-9. Epub 2018 Dec 6.

Background/aim: Anxiety disorders are associated with impairments in several aspects of cognitive processing. In this study we investigated three such aspects, i.e. Read More

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December 2018
1 Read

Clinical Drug Response Prediction by Using a Lq Penalized Network-Constrained Logistic Regression Method.

Cell Physiol Biochem 2018 Dec 6;51(5):2073-2084. Epub 2018 Dec 6.

Faculty of Information Technology & State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.

Background/aims: One of the most important impacts of personalized medicine is the connection between patients' genotypes and their drug responses. Despite a series of studies exploring this relationship, the predictive ability of such analyses still needs to be strengthened.

Methods: Here we present the Lq penalized network-constrained logistic regression (Lq-NLR) method to meet this need, in which the predictors are integrated into the gene expression data and biological network knowledge and are combined with a more aggressive penalty function. Read More

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December 2018
2 Reads

Hot spots for GPCR signaling: lessons from single-molecule microscopy.

Curr Opin Cell Biol 2018 Dec 3;57:57-63. Epub 2018 Dec 3.

Institute of Pharmacology and Bio-Imaging Center, University of Würzburg, Germany.

G protein-coupled receptors (GPCRs) are among the best-studied membrane receptors, mainly due to their central role in human physiology, involvement in disease and relevance as drug targets. Although biochemical and pharmacological studies have characterized the main steps in GPCR signaling, how GPCRs produce highly specific responses in our cells remains insufficiently understood. New developments in single-molecule microscopy have made it possible to study the protein-protein interactions at the basis of GPCR signaling in previously inconceivable detail. Read More

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December 2018
2 Reads

Investigating associations between caffeinated beverage consumption and later alcohol consumption among early adolescents.

Addict Behav 2018 Nov 23;90:362-368. Epub 2018 Nov 23.

Department of Psychology, Rutgers University, Camden 311 North 5th Street, Camden NJ 08102, United States. Electronic address:

Previous research has demonstrated that caffeinated beverage consumption predicts alcohol consumption among early adolescents. This study aimed to investigate this association in two ways: (1) by examining if this association remained significant once other established risk factors for alcohol were adjusted for statistically; and (2) by considering three possible moderators of this association: gender, sensation-seeking, and parental monitoring. Data from the Camden Youth Development Study, a longitudinal, community-based study of middle-school students, were used. Read More

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November 2018

Occurrence and levels of micropollutants across environmental and engineered compartments in Austria.

J Environ Manage 2018 Dec 3;232:636-653. Epub 2018 Dec 3.

Institute for Water Quality and Resource Management, TU Wien, Karlsplatz 13/226, 1040, Vienna, Austria.

Occurrence and concentration of a broad spectrum of micropollutants are investigated in Austrian river catchments, namely polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), organotin compounds, perfluoroalkyl acids (PFAAs) and metals. The parallel analysis across multiple environmental and engineered compartments sheds light on the ratio of dissolved and particulate transport and on differences in concentration levels between point and diffuse emission pathways. It is found that some PAHs and organotins are present in rivers, groundwater and bulk deposition at higher concentrations than in municipal wastewater effluents. Read More

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December 2018
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A systematic review of sudden unexpected death in epilepsy (SUDEP) in childhood.

Epilepsy Behav 2018 Dec 3;90:99-106. Epub 2018 Dec 3.

Population, Policy and Practice Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

Background: Sudden Unexpected Death in Epilepsy (SUDEP) is a significant cause of death in childhood epilepsy, and causes considerable concern to patients and their families. Despite this, the condition remains poorly understood. This systematic review investigates the risk factors, pathophysiology, and circumstances associated with childhood SUDEP. Read More

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December 2018
8 Reads

Online behavior of people visiting a scientific website on epilepsy.

Epilepsy Behav 2018 Dec 3;90:79-83. Epub 2018 Dec 3.

'Sapienza' University of Rome, Human Neuroscience Department, Rome, Italy.

We investigated the online behavior of Internet users consulting the website of the Italian Chapter of the International League Against Epilepsy (Lega Italiana Contro l'Epilessia [LICE]). We obtained the visualization statistics of the LICE website using AWStats (https://awstats.sourceforge. Read More

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December 2018
1 Read

Long-term functional outcome after decompressive suboccipital craniectomy for space-occupying cerebellar infarction.

Clin Neurol Neurosurg 2018 Dec 1;176:47-52. Epub 2018 Dec 1.

Department of Neurosurgery, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Objectives: Suboccipital decompressive craniectomy (SDC) is considered the best treatment option in patients with space-occupying cerebellar infarction and clinical signs of deterioration. The primary purpose of this study was to evaluate long-term functional outcome in patients one year after SDC for space-occupying cerebellar infarction, and secondly, to determine factors associated with outcome.

Patients And Methods: All patients treated with SDC due to space-occupying cerebellar infarction between January 2009 and October 2015 were included in the study. Read More

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December 2018
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Temporal fluctuations in young-of-the-year yellow perch mercury bioaccumulation in lakes of northeastern Minnesota.

Sci Total Environ 2018 Nov 22;656:475-481. Epub 2018 Nov 22.

USDA Forest Service, Superior National Forest, 8901 Grand Ave Place, Duluth, MN 55808, USA. Electronic address:

Identifying what determines fish mercury (Hg) bioaccumulation remains a key scientific challenge. While there has been substantial research on spatial variation in fish Hg bioaccumulation, the factors that influence temporal fluctuations in fish Hg have received less attention to date. In this study, we built upon a growing body of research investigating young-of-the-year (YOY) yellow perch Hg bioaccumulation and investigated annual fluctuations in YOY yellow perch Hg in six lakes in northeastern Minnesota over eight years. Read More

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November 2018
2 Reads

Combined juvenile polyposis syndrome and hereditary hemorrhagic telangiectasia (JPS/HHT) with MRI and endoscopic correlation.

Clin Imaging 2018 Dec 2;54:37-39. Epub 2018 Dec 2.

Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, USA.

Juvenile polyposis syndrome (JPS) may coexist with hereditary hemorrhagic telangiectasia (HHT) due to implication of the SMAD4 gene in a subset of both diseases. To the best of our knowledge, we present the first case in the radiologic literature on the MRI findings in a patient with this rare combined diagnosis undergoing workup for burden of disease. Read More

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December 2018
2 Reads

Prediction of neutrophil-to-lymphocyte ratio in the diagnosis and progression of autoimmune encephalitis.

Neurosci Lett 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurology, Shandong Provincial Hospital affiliated to Shandong University, Jing Wu Road, Huaiyin District, Jinan, 250021, Shandong, China. Electronic address:

Objective: Autoimmune encephalitis (AIE) is a group of inflammatory disorders of the brain. The severity of AIE vary among individuals and it is always a challenge to predict. In this study, we measured the neutrophil-to-lymphocyte ratio (NLR), a novel potential biomarker of inflammatory status in other inflammatory diseases, in AIE patients and evaluated NLR as a biomarker for monitoring AIE progression. Read More

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December 2018
2 Reads

Behavior, experience, skill, and training: a four-pillar framework and tool for career development in science.

Drug Discov Today 2018 Dec 3. Epub 2018 Dec 3.

Pfizer, Pfizer Essential Health, US Medical Affairs Women's s Health. Electronic address:

Technical expertise and a spirit of inquiry serve as cornerstones for a career in science. Within that career, there are multiple pathways across disciplines, therapeutic areas, and sectors. To optimize career planning, I showcase here a career development framework that integrates four pillars: behavior, experience, skill, and training (BEST). Read More

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December 2018
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Preparation and optimization of poly (lactic acid) nanoparticles loaded with fisetin to improve anti-cancer therapy.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

Fisetin is a natural flavonoid with promising antitumor activity, whereas its clinical application is limited by its hydrophobic property. In this study, we aimed to load fisetin into poly(lactic acid) (PLA) nanoparticles to increase fisetin's solubility and therapeutic efficacy. Based on spontaneous emulsification solvent diffusion (SESD) method, the formulation of PLA nanoparticles was optimized by two successive experimental designs. Read More

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December 2018
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Study of the selenizing Codonopsis pilosula polysaccharides protects RAW264.7 cells from hydrogen peroxide-induced injury.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health in Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China. Electronic address:

Codonopsis pilosula polysaccharides (CPPS) has been shown to possess a variety of biological activities. In previous study, CPPS was successfully modified to obtain its best selenizing Codonopsis pilosula polysaccharides (sCPPS). The purpose of this study was to investigate the protective effect of the selenizing derivative of CPPS (sCPPS) from HO-induced oxidative damage in RAW264. Read More

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December 2018
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Enhancement of the carbohydrate content in Spirulina by applying CO, thermoelectric fly ashes and reduced nitrogen supply.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Microbiology and Biochemistry, College of Chemistry and Food Engineering, Federal University of Rio Grande, P.O. Box 474, 96203-900, Rio Grande, RS, Brazil. Electronic address:

This study focused on evaluating whether the injection of CO, which is associated with the use of thermoelectric fly ashes and a reduced supply of nitrogen, affects the production of intracellular carbohydrates from Spirulina. For this purpose, the addition of 0.25 g L of NaNO, along with a 10% (v v) of CO injection, a flow rate of 0. Read More

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December 2018

Physicochemical and functional properties of oleaster (Elaeagnus angustifolia L.) polysaccharides extracted under optimal conditions.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Food Science and Technology, College of Agriculture, Isfahan University of Technology, Isfahan 84156-83111, Iran. Electronic address:

This research aimed to optimize the polysaccharides extraction of oleaster fruit and then to investigate the physicochemical and functional properties of extracted polysaccharides. Temperature, water to dry matter ratio, time, and alcohol ratio were considered as variables. Purity of extracted polysaccharides was considered as the response. Read More

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December 2018

Body composition and sarcopenia: the next-generation of personalized oncology and pharmacology?

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Oncology, CAncer Research for PErsonalized Medicine (CARPEM), Paris Centre Teaching Hospitals, Paris Descartes University, USPC, Paris, France.

Body composition has gained increasing attention in oncology in recent years due to fact that sarcopenia has been revealed to be a strong prognostic indicator for survival across multiple stages and cancer types and a predictive factor for toxicity and surgery complications. Accumulating evidence over the last decade has unraveled the "pharmacology" of sarcopenia. Lean body mass may be more relevant to define drug dosing than the "classical" body surface area or flat-fixed dosing in patients with cancer. Read More

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December 2018
2 Reads

Daily energy expenditure of males following alternative reproductive tactics: Solitary roamers spend more energy than group-living males.

Physiol Behav 2018 Dec 3. Epub 2018 Dec 3.

School of Animal, Plant & Environmental Sciences, University of the Witwatersrand, Private Bag 3, WITS, 2050 Johannesburg, South Africa; IPHC, UNISTRA, CNRS, 23 rue du Loess, 67200 Strasbourg, France.

In many species, males follow alternative reproductive tactics (ARTs), where one tactic (called bourgeois) has much higher reproductive success than alternative tactics followed by males with lower competitive ability. The extent to which ARTs differ in energetic costs is unknown, but it is important to understand the fitness payoffs of ARTs. We studied male African striped mice (Rhabdomys pumilio) which follow one of three ARTs: heavy bourgeois males defend harems of females and have 10 times higher reproductive success than smaller roamers, which have ten times higher reproductive success than philopatric males, which remain in their natal group and are the smallest males. Read More

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December 2018

Anticancer activity modulation of an innovative solid formulation of extra virgin olive oil by cultured zeolite scaffolds.

Food Chem Toxicol 2018 Dec 3. Epub 2018 Dec 3.

Research Institute on Membrane Technology, Unit of Zeolite Membranes, ITM-CNR, University of Calabria, Cubo 17/c, 87036, Rende, Italy.

This paper deals with the design and manufacture of pure and hybrid synthetic (Mixed Matrix Membranes, MMMs) zeolite scaffolds (containing various amount of zeolite crystals dispersed in a polymeric matrix) to obtain new biomaterials. These scaffolds can potentially be used in the field of translational medicine to obtain innovative results to address tumorigenesis mechanisms with the promotion of an effort to deal with technical methods and information. Since olive oil has beneficial effects in healthy human cells and slows down and/or inhibits cell growth, the aim of this work was to monitor the protective and beneficial antitumor effects of olive oil in a new solid formulation (Spread Bio-Oil) on cancer cell cultured on zeolite scaffolds. Read More

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December 2018

Animal Conflicts in Diploid Populations with Sexual Reproduction.

J Theor Biol 2018 Dec 3. Epub 2018 Dec 3.

Ruppin Academic Center, School of Engineering, Unit of Engineering & Management, Emek Hefer 40250, Israel. Electronic address:

The classical, monomorphic, evolutionary games analyze competition among phenotypes while implicitly assuming monomorphic transmission of phenotypic attributes to successive generations. The recently formulated polymorphic evolutionary game theory (PEGT), which adds the underlying genetics and sexual reproduction to evolutionary games, has the potential to revolutionize game theoretical modeling of co-evolutionary processes. In this paper, I apply PEGT methods to the analysis of animal conflicts ࣧ the oldest, and one of the best-developed areas of evolutionary game modeling. Read More

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December 2018

Bezlotoxumab Use as Adjunctive Therapy with the Third Fecal Microbiota Transplant in Refractory Recurrent Clostridium Difficile Colitis; A Case Report and Concise Literature Review.

Anaerobe 2018 Dec 3. Epub 2018 Dec 3.

ABIM Board Certified in Focused Practice in Hospital Medicine (FPHM), Mercy Clinic Hospitalist, Physician Building, 7301 Rogers Ave, Fort Smith, AR, 72903, United States. Electronic address:

Clostridium difficile is the most commonly reported pathogen to cause nosocomial infections in the United States with a high burden affecting morbidity, mortality and healthcare expenditure. The use of Fecal Microbiota Transplantation (FMT) is one of the current standard therapies for recurrent C. difficile infection (CDIr). Read More

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December 2018

Identifiers of Language Impairment for Spanish-English Dual Language Learners.

Lang Speech Hear Serv Sch 2018 Dec 6:1-12. Epub 2018 Dec 6.

Department of Communication Sciences and Disorders, University of Cincinnati, Ohio.

Purpose: The purpose of this study was to determine if a standardized assessment developed for Spanish-English dual language learners (SEDLLs) differentiates SEDLLs with language impairment (LI) from children with typical language better than the translated/adapted Spanish and/or English version of a standardized assessment and to determine if adding informal measure/s to the standardized assessment increases the classification accuracy.

Method: Standardized and informal language assessment measures were administered to 30 Mexican American 4- to 5-year-old SEDLLs to determine the predictive value of each measure and the group of measures that best identified children with LI and typical language. Discriminant analyses were performed on the data set. Read More

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December 2018
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Comparison of Three-Dimensional Accuracy of Digital and Conventional Implant Impressions: Effect of Interimplant Distance in an Edentulous Arch.

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: This study compared the three-dimensional (3D) accuracy of conventional impressions with digital impression systems (intraoral scanners and dental laboratory scanners) for two different interimplant distances in maxillary edentulous arches.

Materials And Methods: Six impression systems comprising one conventional impression material(Impregum), two intraoral scanners (TRIOS and True Definition), and three dental laboratory scanners (Ceramill Map400, inEos X5, and D900) were evaluated on two completely edentulous maxillary arch master models (A and B) with six and eight implants, respectively. Centroid positions at the implant platform level were derived using either physical or virtual probe hits with a coordinate measuring machine. Read More

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December 2018
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Quantification of image artifacts from navigation markers in dynamic guided implant surgery and the effect on registration performance in different clinical scenarios.

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: Different navigation markers in dynamic guided implant surgery could cause different degrees of artifacts, which would affect the accuracy and efficiency of the implant navigation system. This study aimed to quantify artifacts caused by navigation markers made of different materials and to evaluate their effects on registration accuracy under various oral conditions.

Materials And Methods: Four U-shaped tubes with different navigation markers (440c stainless steel, silicon nitride, zirconium oxide, and aluminium oxide) were produced by three-dimensional printing. Read More

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December 2018
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Application of the Andersen-Newman model of health care utilization to understand antenatal care use in Kersa District, Eastern Ethiopia.

PLoS One 2018 6;13(12):e0208729. Epub 2018 Dec 6.

Research Centre for Generational Health and Ageing, Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW, Australia.

Background: In Ethiopia, the uptake of antenatal care services has been low. Moreover, there is less frequent and late attendance of antenatal care among women who attend. Using the Anderson-Newman model of health care utilization, this study identified factors that either facilitate or impede antenatal care utilization in Kersa district, Eastern Ethiopia. Read More

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December 2018
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Age trends in asymptomatic and symptomatic Leishmania donovani infection in the Indian subcontinent: A review and analysis of data from diagnostic and epidemiological studies.

PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006803. Epub 2018 Dec 6.

Zeeman Institute, University of Warwick, Coventry, United Kingdom.

Background: Age patterns in asymptomatic and symptomatic infection with Leishmania donovani, the causative agent of visceral leishmaniasis (VL) in the Indian subcontinent (ISC), are currently poorly understood. Age-stratified serology and infection incidence have been used to assess transmission levels of other diseases, which suggests that they may also be of use for monitoring and targeting control programmes to achieve elimination of VL and should be included in VL transmission dynamic models. We therefore analysed available age-stratified data on both disease incidence and prevalence of immune markers with the aim of collating the currently available data, estimating rates of infection, and informing modelling and future data collection. Read More

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December 2018
2 Reads

Bayesian adaptive dual control of deep brain stimulation in a computational model of Parkinson's disease.

PLoS Comput Biol 2018 Dec 6;14(12):e1006606. Epub 2018 Dec 6.

Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.

In this paper, we present a novel Bayesian adaptive dual controller (ADC) for autonomously programming deep brain stimulation devices. We evaluated the Bayesian ADC's performance in the context of reducing beta power in a computational model of Parkinson's disease, in which it was tasked with finding the set of stimulation parameters which optimally reduced beta power as fast as possible. Here, the Bayesian ADC has dual goals: (a) to minimize beta power by exploiting the best parameters found so far, and (b) to explore the space to find better parameters, thus allowing for better control in the future. Read More

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December 2018

Laparoscopic sleeve gastrectomy and gastroesophageal reflux.

Rom J Intern Med 2018 Dec;56(4):227-232

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

The prevalence of obesity is rising, becoming a medical problem worldwide. Also GERD incidence is higher in obese patients compared with normal weight, with an increased risk of 2.5 of developing symptoms and erosive esophagitis. Read More

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December 2018

Faecal incontinence: investigation, treatment and management.

Authors:
Linda Nazarko

Br J Community Nurs 2018 Dec;23(12):582-588

Consultant nurse, physical healthcare, West London Mental Health Trust.

Faecal incontinence (FI) is a hidden problem that is under-diagnosed, under-investigated and under treated. Up to 10% of adults can experience an episode of FI. The prevalence of FI in the adult population has been estimated at 0. Read More

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December 2018
2 Reads

Obstetric Racism: The Racial Politics of Pregnancy, Labor, and Birthing.

Authors:
Dána-Ain Davis

Med Anthropol 2018 Dec 6:1-14. Epub 2018 Dec 6.

a Center for the Study of Women and Society, Graduate Center , City University of New York , New York , USA.

In this article, I analyze the birth stories of Black women living in the United States. Their birth stories describe various forms of racism during medical encounters while they were pregnant or during labor and delivery. In the global women's health arena, the issues raised are viewed as obstetric violence. Read More

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December 2018

Can early detection prevent venous leg ulceration?

Authors:
Michelle Porter

Br J Community Nurs 2018 Dec;23(Sup12):S14-S17

Senior Tissue Viability Clinical Nurse Specialist, Lincolnshire Community Health Services NHS Trust.

Venous leg ulceration is the most common form of leg ulceration, affecting 1.5% of the UK adult population. This was reviewed within the latest best practice statement (2016) which set out to create clear guidance on the assessment, management and preventing the reoccurrence of venous leg ulceration. Read More

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December 2018

Monitoring service quality: Lindsay Leg Club member satisfaction survey.

Authors:
Ellie Lindsay

Br J Community Nurs 2018 Dec;23(Sup12):S24-S28

OBE FQNI Life President, Lindsay Leg Club Foundation.

The Lindsay Leg Club network is a research-based initiative that provides treatment, health guidance, education and ongoing care for people of all age groups who are experiencing lower limb-related problems. Leg Club clinicians work in a unique partnership with patients (known as 'members') and the local community. Working to current best-practice guidelines, they provide a high standard of care in a social and friendly setting that promotes understanding, peer support and informed choice. Read More

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December 2018

The value of the Lindsay Leg Club Foundation.

Authors:
Wendy Higson

Br J Community Nurs 2018 Dec;23(Sup12):S40-S41

Tissue Viability Nurse, Adam Practice Surgery, The Best Foot Forward Leg Club.

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December 2018

Performance of DFT for C Isomerization Energies: A Noticeable Exception to Jacob's Ladder.

J Phys Chem A 2018 Dec 6. Epub 2018 Dec 6.

The ability to accurately calculate relative energies of fullerenes is important in many areas of computational nanotechnology. Due to the large size of fullerenes, their relative energies cannot normally be calculated by means of high-level ab initio procedures, and therefore density functional theory (DFT) represents a cost-effective alternative. In an extensive benchmark study, we calculate the electronic energies of eight C60 isomers by means of the high-level G4(MP2) composite procedure. Read More

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December 2018
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Assessing the Performance of the Nonbonded Mg2+ Models in a Two-metal-dependent Ribonuclease.

J Chem Inf Model 2018 Dec 6. Epub 2018 Dec 6.

Magnesium ions (Mg2+), abundant in living cells, are essential for biomolecular structure, dynamics, and function. The biological importance of Mg2+ has motivated continuous development and improvement of various Mg2+ models for molecular dynamics (MD) simulations during the last decades. There are four types of nonbonded Mg2+ models: the point charge models based on a 12-6 or 12-6-4 type Lennard-Jones (LJ) potential, and the multisite models based on a 12-6 or 12-6-4 LJ potential. Read More

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December 2018
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Evaluation of the Serum Levels of Galectin-3 in Patients with Oral Lichen Planus Disease.

Oral Dis 2018 Dec 6. Epub 2018 Dec 6.

Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: Galectin-3, a member of beta-galactoside-binding proteins, can be found in cytoplasm and nucleus as well as extracellularly in various tissues and involved in many physiological and pathological processes. We aimed to measure the serum levels of galectin-3 in oral lichen planus (OLP) disease and compare the result with that observed in healthy ones.

Materials And Methods: In this cross-sectional study, the serum levels of galectin-3 were measured in 56 healthy individuals and 53 pathologically proven OLP patients including those with atrophic/erosive (33 cases) or reticular (20 cases) lesions, using enzyme-linked immunosorbent assay (ELISA). Read More

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December 2018
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Validation of the 2017 European LeukemiaNet classification for acute myeloid leukemia with NPM1 and FLT3-internal tandem duplication genotypes.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: The revised 2017 European LeukemiaNet (ELN) classification (ELN-2017) of acute myeloid leukemia (AML) divides patients into 3 prognostic risk categories, with additional factors such as the fms-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) allele ratio (AR) considered for risk stratification. To the best of the authors' knowledge, the prognostic usefulness of ELN-2017 in comparison with ELN-2010 in younger patients with AML has not been validated to date.

Methods: The authors performed a retrospective study on patients aged <60 years who received idarubicin plus cytarabine (IA)-based induction chemotherapy for newly diagnosed AML. Read More

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December 2018

Glomerular filtration rate: when to measure and in which patients?

Nephrol Dial Transplant 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Dialysis, Transplantation, University of Liège (CHU ULg), Liège, Belgium.

Of the glomerular, tubular and endocrine functions of the kidney, nephrologists have mostly focused their attention on the glomerular functions-albuminuria and glomerular filtration rate (GFR)-to grade the severity of chronic kidney disease (CKD). Although both albuminuria and GFR are associated with renal and cardiovascular morbidity and mortality, the utility of measured GFR (mGFR) has been questioned. GFR when measured adequately is the most precise measure of glomerular function and can be useful to individualize therapy among patients with CKD. Read More

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December 2018
2 Reads

Protein-protein interaction sites prediction by ensemble random forests with synthetic minority oversampling technique.

Bioinformatics 2018 Dec 5. Epub 2018 Dec 5.

Bioinformatics and Mathematical Biosciences Lab, Department of Agronomy, Horticulture and Plant Science, South Dakota State University, Brookings, SD, USA.

Motivation: The prediction of protein-protein interaction (PPI) sites is a key to mutation design, catalytic reaction, and the reconstruction of PPI networks. It is a challenging task considering the significant abundant sequences and the imbalance issue in samples.

Results: A new ensemble learning based method, EL-SMURF, was proposed for PPI sites prediction in this study. Read More

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December 2018
1 Read

Deriving an Adolescent Executive Behavior Screener from the Behavior Assessment System for Children-2.

Arch Clin Neuropsychol 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychology, University of Victoria, Victoria, BC, Canada.

Objective: Typical executive functioning (EF) measurements do not reflect the complexity of daily life. We derived an executive behavior screener from the BASC-2-PRS-A using a previously derived four-component model of EF and provided support for the use of the screener in adolescent populations.

Methods: A total of 2,722 census-matched American adolescents were sampled. Read More

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December 2018

The Yale Center for Biomedical Innovation and Technology (CBIT): One Model to Accelerate Impact From Academic Health Care Innovation.

Acad Med 2018 Dec 4. Epub 2018 Dec 4.

A.L. Siefert is engineering director, Yale Center for Biomedical Innovation and Technology (CBIT), and biomedical engineering lecturer, Yale University, New Haven, Connecticut. M.S. Cartiera is investment and innovation director, Yale CBIT and Center for Health Innovation, Yale New Haven Health System, New Haven, Connecticut. A.N. Khalid is clinical director, Yale CBIT, New Haven, Connecticut; and clinical instructor, Harvard Medical School, Boston, Massachusetts. M.C. Nantel is program coordinator, Yale CBIT, New Haven, Connecticut. C.R. Loose is co-executive director, Yale CBIT, New Haven, Connecticut; and chief scientific officer, Frequency Therapeutics, Cambridge, Massachusetts. P.G. Schulam is co-founder, Yale CBIT, chair of Urology, Yale School of Medicine, and faculty director, Tsai Center for Innovative Thinking, Yale University, New Haven, Connecticut. W.M. Saltzman is co-founder, Yale CBIT, and Goizueta Foundation Professor of biomedical and chemical engineering, Yale University, New Haven, Connecticut. M.K. Dempsey is co-executive director, Yale CBIT, New Haven, Connecticut; and entrepreneur-in-residence, Consortia for Improving Medicine with Innovation & Technology (CIMIT), Boston, Massachusetts.

The process of translating academic biomedical advances into clinical care improvements is difficult, risky, expensive, and poorly understood. Notably, many clinicians who identify health care problems do not have the time or expertise to solve the problems, and many academic researchers are unaware of important gaps in clinical care to which their expertise may apply.Recognizing an opportunity to connect people who can identify health care problems with those who can solve them, the Yale Center for Biomedical Innovation and Technology (CBIT) was established in 2014 to educate and enhance the impact of health care innovators. Read More

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December 2018
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Biomarkers for chronic obstructive pulmonary disease diagnosis and progression: insights, disappointments and promise.

Authors:
David M Mannino

Curr Opin Pulm Med 2018 Dec 4. Epub 2018 Dec 4.

Medical Affairs, GlaxoSmithKline, Philadelphia, Pennsylvania.

Purpose Of Review: This article reviews the status of biomarkers useful in the diagnosis and progression of chronic obstructive pulmonary disease (COPD). Biomarkers have been the focus of a great deal of COPD-related research in recent years, although useful markers in these specific arenas remain elusive.

Recent Findings: No biomarker other than lung function has been shown to be useful, to date, for the diagnosis of COPD. Read More

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December 2018

Case Report in Clinical Pediatric Dentistry: How to Review, Organize and Prepare a Manuscript.

J Clin Pediatr Dent 2018 Dec 6. Epub 2018 Dec 6.

A case report is a useful type of publication to describe information on unusual clinical diseases or syndromes, new management techniques, potential risk factors/oral disease associations, and uncommon side effects or responses to traditional dental treatments. In the practice of Dentistry and Medicine, the publication of case reports has the purpose of sharing new clinical experiences and knowledge with interested colleagues. Case reports in the field of Evidence-Based Pediatric Dentistry convey unique contributions to the clinical practice and help improve the process of clinical decision making in the form of a brief written communication. Read More

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December 2018

Development and validation of the Adult Interpersonal Acceptance-Rejection Scale: Measuring mother, best friend, and romantic partner acceptance.

Psychol Assess 2018 Dec 6. Epub 2018 Dec 6.

Social and Behavioral Sciences Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Acceptance-rejection studies and inventories commonly examine children's relationships with parents, but no measurement scale is available in the literature to assess interpersonal acceptance across adulthood close relationships. The Adult Interpersonal Acceptance-Rejection Scale (AIARS) was developed, validated, and psychometrically scrutinized across three studies using independent samples of adult participants. In Study 1 (N = 342), the created items were administered to participants and data were subjected to exploratory factor analysis. Read More

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December 2018

Hybrid Nanomaterials of Conjugated Polymers and Albumin for Precise Photothermal Therapy.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Heretofore, conjugated polymers (CPs) attract considerable attention in photothermal therapy (PTT). Although various CPs with different structures have been reported, the suboptimal circulation persistence and biodistribution limit their efficacy in tumor treatment. Human serum albumin (HSA), an endogenous plasm protein, has been widely functioned as a carrier for therapeutic agents. Read More

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December 2018

Synthesis of novel derivatives of 7,8-dihydro-6H-imidazo[2,1-b][1,3]benzothiazol-5-one and their virus-inhibiting activity against influenza A virus.

Arch Pharm (Weinheim) 2018 Dec 6. Epub 2018 Dec 6.

Fluoro and Agrochemicals Division (Organic Chemistry Division-II), CSIR - Indian Institute of Chemical Technology, Hyderabad, India.

Influenza remains a highly pathogenic and hardly controlled human infection. The ability of selecting drug-resistant variants necessitates the search and development of novel anti-influenza drugs. Herein, we describe the synthesis and evaluation of a series of novel 2-substituted 7,8-dihydro-6H-imidazo[2,1-b][1,3]benzothiazol-5-ones 3a-k for their virus-inhibiting activity against influenza A virus. Read More

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December 2018
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[The hybrid strategy for complete myocardial revascularization in the frail elderly patient].

G Ital Cardiol (Rome) 2018 Nov;19(11):33-38

U.O.C. Cardiologia, Ospedale Belcolle, Viterbo.

The hybrid strategy allows for a complete myocardial revascularization in patients with multivessel coronary artery disease and a high frailty index. These patients, due to their old age and multi-comorbidities, are evaluated with inadequate tools for their clinical complexity and destined to an incomplete revascularization for increased surgical or procedural risk. Hybrid revascularization enables to use the best techniques resulting from the surgical and percutaneous approach defining a tailored strategy for the patient. Read More

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November 2018
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[Coronary artery disease: when to withhold a decision and call in the Heart Team? Almost every time].

Authors:
Lucia Torracca

G Ital Cardiol (Rome) 2018 Nov;19(11):14-17

U.O. Cardiochirurgia, Humanitas Research Hospital, Rozzano (MI).

The multidisciplinary discussion is a well-established method, highly widespread in different medical disciplines, with documented optimal results. This practice, despite mandate by international guidelines, is not universally applied to guide treatment in coronary artery disease (CAD) patients. The literature provides data both on overtreatment or undertreatment in different patient subsets, clearly suggesting its strong need. Read More

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November 2018

Concurrent validity and reliability of proprietary and open-source jump mat systems for the assessment of vertical jumps in sport sciences.

Acta Bioeng Biomech 2018 ;20(4):51-57

Department of Sport Sciences, University of Alicante, Ctra. San Vicente, Alicante, Spain.

Purpose: Vertical jump tests are used to assess lower-limb power of athletes in sport sciences. Flight time measurement with jump-mat systems is the most common procedure for this purpose. The aim of this study was to analyze the concurrent validity and reliability of two proprietary systems (Globus and Axon) and an open-source system (Chronojump). Read More

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January 2018