493,003 results match your criteria Best Practice & Research: Clinical Haematology[Journal]


Six-year outcome for children with ODD or CD treated with the coping power program.

Psychiatry Res 2018 Dec 4;271:454-458. Epub 2018 Dec 4.

The University of Alabama, Tuscaloosa, AL USA.

Children with severe aggressive behavioral problems are one of the groups most frequently referred to mental health clinics, and they engage in behaviors that put them at risk for substance use problems and a host of other negative outcomes. The present study aimed to assess the long-term outcome (six-year follow up) of the Coping Power Program delivered in a mental health hospital for children with behavioral disorders. We recruited one hundred and twenty children (mean age = 9. Read More

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December 2018

QSPR estimation models of normal boiling point and relative liquid density of pure hydrocarbons using MLR and MLP-ANN methods.

J Mol Graph Model 2018 Nov 29;87:109-120. Epub 2018 Nov 29.

Laboratory of Biomaterials and Transport Phenomena (LBMPT), University of Médéa, Médéa, 26000, Algeria.

This work aimed to predict the normal boiling point temperature (Tb) and relative liquid density (d20) of petroleum fractions and pure hydrocarbons, through a multi-layer perceptron artificial neural network (MLP-ANN) based on the molecular descriptors. A set of 223 and 222 diverse data points for Tb and d20 were respectively used to build two quantitative structure property relationships-artificial neural network (QSPR-ANN) models. For each model, the total database was divided respectively into two subsets: 80% for the training set and 20% for the test set. Read More

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November 2018

Action research improves services for child sexual abuse in one Caribbean nation: An example of good practice.

Child Abuse Negl 2018 Dec 8;88:225-234. Epub 2018 Dec 8.

Institute of Gender and Development Studies, The University of the West Indies, St. Augustine, Trinidad and Tobago.

Background: Child sexual abuse (CSA) is a multi-dimensional problem. The search for best practice must consider the complexities surrounding CSA and its management in any particular society.

Objective: Data previously gathered from service providers on CSA service provision in Trinidad and Tobago identified key deficient issues in policy and practice. Read More

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December 2018

A semi-mechanistic model describing the influence of light and temperature on the respiration and photosynthetic growth of Chlorella vulgaris.

Bioresour Technol 2018 Nov 29;274:361-370. Epub 2018 Nov 29.

Laboratory for Industrial Water and Ecotechnology (LIWET), Department of Green Chemistry and Technology, Ghent University Campus Kortrijk, Graaf Karel de Goedelaan 5, B-8500 Kortrijk, Belgium.

The influence of light and temperature on microalgae kinetics has been assessed extensively and many models have been developed. However, limited attention has been paid to the influence of light and temperature on microalgae respiration and growth under conditions inducing (strong) photoinhibition and no clear consensus has been made on which model to use. Based on experimental data collected using a combined respirometer-titrimeter, a previously developed microalgae model (Decostere et al. Read More

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November 2018

Adsorption and mechanistic study for phosphate removal by magnetic FeO-doped spent FCC catalysts adsorbent.

Chemosphere 2018 Nov 21;219:183-190. Epub 2018 Nov 21.

State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, East China University of Science and Technology, Shanghai, 200237, China.

The waste materials utilization has attained increasing attention due to the generation of a large number of spent materials. In the current study, a practical magnetic adsorbent (FeO-doped spent Fluid Catalytic Cracking catalysts, abbreviated as FCC@(Fe)-O) was prepared, liable to be separated. The batch experiments were employed to investigate the phosphate removal behavior. Read More

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November 2018

Effectiveness assessment of risk reduction measures at coastal areas using a decision support system: Findings from Emma storm.

Sci Total Environ 2018 Dec 1;657:124-135. Epub 2018 Dec 1.

CIMA/FCT, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal. Electronic address:

Storms impact coastal areas often causing damages and losses at occupied areas. On a scenario of increasing human occupation at coastal zones and under climate change conditions (including sea level rise and increasing frequency of extreme sea levels), the consequences of storms are expected to be amplified if no adaptation or further management actions are implemented. The selection of the best possible coastal management measures, considering both costs and effectiveness, will be mandatory in the future, in order to optimise resources. Read More

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December 2018

Surgical Risk Stratification Based on Preoperative Risk Factors in Adult Spinal Deformity.

Spine J 2018 Dec 8. Epub 2018 Dec 8.

Department of Orthopedic Surgery, Keio University School of Medicine; Keio Spine Research Group. Electronic address:

Background Context: Corrective surgery for adult spinal deformity (ASD) improves health-related quality of life but has high complication rates. Predicting a patient's risk of perioperative and late postoperative complications is difficult, although several potential risk factors have been reported.

Purpose: To establish an accurate, ASD-specific model for predicting the risk of postoperative complications, based on baseline demographic, radiographic, and surgical invasiveness data in a retrospective case series. Read More

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December 2018
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Posterior staphyloma in pathologic myopia.

Prog Retin Eye Res 2018 Dec 8. Epub 2018 Dec 8.

Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. Electronic address:

A posterior staphyloma is an outpouching of a circumscribed region of the posterior fundus and has been considered a hallmark of pathologic myopia. Occurring in highly myopic eyes, it is histologically characterized by a relatively abrupt scleral thinning starting at the staphyloma edge, a pronounced de-arrangement of scleral collagen fibrils and a marked choroidal thinning, which is the most marked at the staphyloma edge and which occurs in addition to the axial elongation-associated choroidal thinning. Besides in highly myopic eyes, a posterior staphyloma can be found in non-highly myopic eyes in association with retinitis pigmentosa or localized defects of Bruch's membrane in the cases of which it is not associated with a marked choroidal thinning. Read More

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December 2018
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A Comprehensive Analysis of Protocols for Deriving Dopaminergic Neurons from Human Pluripotent Stem Cells.

Stem Cells Transl Med 2018 Dec 10. Epub 2018 Dec 10.

Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, California, USA.

The potential applications of human embryonic and induced pluripotent stem cells has led to immense interest in developing new protocols to differentiate specific cell types or modifying existing protocols. To investigate to what extent and why new protocols for the same cell types are developed and adopted, we systematically evaluated 158 publications (2004-2017) that differentiated human stem cells into dopaminergic neurons. We categorized each article by degree of novelty and recorded motivations for protocol development. Read More

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December 2018

Redefining the fluoroscopic landmarks for common femoral arterial puncture during cardiac catheterization: Femoral angiogram and computed tomography angiogram (FACT) study of common femoral artery anatomy.

Catheter Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiology, Aultman Hospital, Canton, Ohio.

Background: The mid-femoral head (F ) is a common fluoroscopic target for common femoral artery (CFA) puncture during cardiac catheterization. Punctures above the inguinal ligament (marking the proximal end of CFA) increase the risk of retroperitoneal hemorrhage and are classified as high punctures.

Methods: We retrospectively analyzed 114 CT angiograms for the anatomic relationship of the inguinal ligament to the femoral head (FH) and inferior epigastric artery (IEA). Read More

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December 2018

Urine sediment examination: Potential impact of red and white blood cell counts using different sediment methods.

Vet Clin Pathol 2018 Dec 11. Epub 2018 Dec 11.

IDEXX Laboratories, Inc., Westbrook, Maine.

Background: Centrifugation is the primary method used to perform urine sediment analyses, but evaluation of other methods is required to validate centrifugation.

Objectives: Non-urine materials were used to examine the repeatability (precision) and effectiveness (recovery) of four sediment methodologies on red blood cell (RBC) and white blood cell (WBC) counts.

Methods: Four urine sediment methods were compared using commercially available quality control material (QCM) and fresh canine RBCs in a diluent. Read More

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December 2018

Differential regulation of intestinal and hepatic CYP3A by 1α,25-dihydroxyvitamin D : Effects on in vivo oral absorption and disposition of buspirone in rats.

Drug Dev Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Manufacturing Pharmacy, College of Pharmacy, Pusan National University, Busan, South Korea.

1α,25-Dihydroxyvitamin D (also called 1,25(OH) D or calcitriol) is the biologically active form of vitamin D, which functions as a ligand to the vitamin D receptor (VDR). It was previously reported that intestinal cytochrome P450 3A (CYP3A) expression was altered by 1,25(OH) D -mediated VDR activation. However, to clarify whether the change in CYP3A subfamily expression by VDR activation can affect metabolic function, further evidence is needed to prove the effect of 1,25(OH) D treatment on CYP3A-mediated drug metabolism and pharmacokinetics. Read More

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December 2018
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Population Pharmacokinetics and Bayesian Estimation of Mycophenolic Acid Exposure in Chinese Renal Allograft Recipients After Administration of EC-MPS.

J Clin Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Organ Transplantation Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The aim of the present study is to establish a population pharmacokinetic (PPK) model of mycophenolic acid (MPA) and limited sampling strategy models for the estimation of MPA exposure in Chinese adult renal allograft recipients following oral administration of enteric coated mycophenolate sodium (EC-MPS). A total of 74 sets of full pharmacokinetic profiles and 47 sets of MPA-sparing samples were collected from 102 renal transplant recipients who received oral EC-MPS. The MPA concentration was determined by an enzyme-multiplied immunoassay technique, and the pathophysiologic data were recorded. Read More

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December 2018

A review of interventions supporting parent's psychological well-being after a child's intensive care unit discharge.

Nurs Crit Care 2018 Dec 10. Epub 2018 Dec 10.

School of Health and Social Care, London South Bank University, London, UK.

Background: Having a child admitted to a paediatric intensive care unit (PICU) is a highly stressful experience, and post-traumatic stress among parents is well documented. How best to support these parents is currently unclear.

Aim: To review research on interventions to support the psychological well-being of parents after their child's discharge from paediatric intensive care. Read More

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December 2018

Comparison of polyhexanide, cold atmospheric plasma and saline in the treatment of canine bite wounds.

J Small Anim Pract 2018 Dec 11. Epub 2018 Dec 11.

Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximilians-University, Munich 80539, Germany.

Objectives: To compare the efficacy of polyhexanide, cold argon plasma and saline in reducing bacterial bio-burden in dog bite wounds.

Materials And Methods: Prospective blinded randomised clinical trial. Dogs were randomly assigned to one of the treatment groups by lottery and bacterial cultures obtained before and after treatment were compared. Read More

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December 2018

Benchmarking life quality support interventions in long-term care using the Long-Term Care Quality of Life scale.

Nurs Health Sci 2018 Dec 10. Epub 2018 Dec 10.

Department of Nursing, Midwifery & Paramedicine, Faculty of Health Sciences, Australian Catholic University, Sydney, New South Wales, Australia.

We aimed to develop a graphical procedure for benchmarking quality of life care results using the Long-Term Care Quality of Life (LTC-QoL) scale. While clinical care quality benchmarking is now well established, similar research for quality of life (QOL) aged care benchmarking has received scant attention. Data from 10 facilities utilizing the LTC-QoL scale were analysed to establish baseline statistics for developing a graphical procedure for QOL benchmarking. Read More

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December 2018
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High-sensitivity Cardiac Troponin T as a Predictor of Acute Total Occlusion in Patients with Non-ST-segment Elevation Acute Coronary Syndrome.

Clin Cardiol 2018 Dec 7. Epub 2018 Dec 7.

Cardiology Department, Instituto Cardiovascular de Buenos Aires (ICBA), Buenos Aires, Argentina.

Background: A large percentage of patients with non-ST-segment acute coronary syndrome (NSTE-ACS) present with acute total occlusion (TO) of some major epicardial vessel that does not generate electrocardiographic changes. Ongoing research into the methods of accurately predicting acute TO have not yielded great success. The present study aimed to evaluate the predictive value of high-sensitivity cardiac troponin T (hs-cTnT) for the presence of acute TO of the culprit artery in patients with NSTE-ACS. Read More

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December 2018

Supraglottic Squamous Cell Carcinoma: A Population-Based Study of 22,675 Cases.

Laryngoscope 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A.

Objectives/hypothesis: The authors used the Surveillance, Epidemiology, and End Results (SEER) database to analyze epidemiological features of patients presenting with supraglottic squamous cell carcinoma (SCCa) and to evaluate treatment trends and outcomes.

Methods: The SEER database was queried for patients with supraglottic SCCa from 1973 to 2013. Information on demographics; tumor size; histologic grade; American Joint Committee on Cancer (AJCC) stage; SEER local, regional, distant stage; and treatment modality were analyzed. Read More

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December 2018
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One-millimeter isotropic breast diffusion-weighted imaging: Evaluation of a superresolution strategy in terms of signal-to-noise ratio, sharpness and apparent diffusion coefficient.

Magn Reson Med 2018 Dec 10. Epub 2018 Dec 10.

IADI, INSERM U1254 and Université de Lorraine, Nancy, France.

Purpose: To quantitatively evaluate a superresolution technique for 3D, one-millimeter isotropic diffusion-weighted imaging (DWI) of the whole breasts.

Methods: Isotropic 3D DWI datasets are obtained using a combination of (i) a readout-segmented diffusion-weighted-echo-planar imaging (DW-EPI) sequence (rs-EPI), providing high in-plane resolution, and (ii) a superresolution (SR) strategy, which consists of acquiring 3 datasets with thick slices (3 mm) and 1-mm shifts in the slice direction, and combining them into a 1 × 1 × 1-mm dataset using a dedicated reconstruction. Two SR reconstruction schemes were investigated, based on different regularization schemes: conventional Tikhonov or Beltrami (an edge-preserving constraint). Read More

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December 2018

An In Silico approach to discover the best molecular modelling strategy for designing novel CDK4 inhibitors.

Chem Biol Drug Des 2018 Dec 8. Epub 2018 Dec 8.

Department of Chemistry, Sree Narayana College, Kollam, Kerala, India, 691001.

Designing of new potential specific inhibitors for CDK4 is very important in cancer therapy. The imperative features that can inhibit CDK4 were identified and refined by docking under standard precision mode, extra precision mode, extra precision mode with core-constraints and induced fit using extra precision protocol. Statistically significant correlation was observed when docking experiments in the extra precision mode carried out by applying core constraints in the ligand molecule which forms two specific hydrogen bonds with Val96 of CDK4. Read More

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December 2018

Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop.

J Am Geriatr Soc 2018 Dec 7. Epub 2018 Dec 7.

Cardiovascular Division, Department of Internal Medicine, Washington University, St. Louis, Missouri.

Objectives: To identify the top priority areas for research to optimize pharmacotherapy in older adults with cardiovascular disease (CVD).

Design: Consensus meeting.

Setting: Multidisciplinary workshop supported by the National Institute on Aging, the American College of Cardiology, and the American Geriatrics Society, February 6-7, 2017. Read More

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December 2018

Preventive effect of omega-3 fatty acids in a rat model of stress-induced liver injury.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Histology and Cell Biology Department, Faculty of Medicine, Minia University, Minia, Egypt.

Omega-3 fatty acids are gaining attention as a therapeutic agent of many diseases. Their protective effect in a variety of diseases has been demonstrated. To the best of our knowledge, this is the first study on omega-3 fatty acids related to acute cold-restraint stress (CRS) induced hepatic dysfunction in rats. Read More

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December 2018

A Click-Chemistry Linked 2'3'-cGAMP Analog.

Chemistry 2018 Dec 10. Epub 2018 Dec 10.

Ludwig-Maximilians-Universität München, Department of Chemistry and Biochemistry, Butenandtstraße 5-13, 81377, München, GERMANY.

2'3'-cGAMP is an uncanonical cyclic dinucleotide where one A and one G base are connected via a 3'-5' and a unique 2'-5' linkage. The molecule is produced by the cyclase cGAS in response to cytosolic DNA binding. cGAMP activates STING and hence one of the most powerful pathways of innate immunity. Read More

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December 2018

Pre-operative factors influencing post-operative outcomes from MyoRing implantation in keratoconus.

Clin Exp Optom 2018 Dec 7. Epub 2018 Dec 7.

Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Background: To identify pre-operative factors that influence post-operative performance of a full-ring intra-corneal implant (MyoRing) for the management of keratoconus.

Method: In a retrospective study, medical records of 70 keratoconus eyes of 70 consecutive surgical patients with a mean age of 28.54 ± 6. Read More

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December 2018

Dopamine, oxidative stress and protein-quinone modifications in Parkinson's and other neurodegenerative diseases.

Angew Chem Int Ed Engl 2018 Dec 11. Epub 2018 Dec 11.

Universita degli Studi di Pavia, Chimica, Via Taramelli 12, 27100, Pavia, ITALY.

Dopamine (DA) is the most important catecholamine in the brain, as it is the most abundant and the precursor of other neurotransmitters. Degeneration of nigrostriatal neurons of substantia nigra pars compacta in Parkinson's disease represents the best-studied link between DA neurotransmission and neuropathology. Catecholamines are reactive molecules that are handled through complex control and transport systems. Read More

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December 2018

Platelet storage properties are associated with donor age: in vitro quality of platelets from young donors and older donors with and without Type 2 diabetes.

Vox Sang 2018 Dec 10. Epub 2018 Dec 10.

Department of Product and Process Development, Sanquin Blood Bank, Amsterdam, the Netherlands.

Background And Objectives: Previously it has been shown that platelet (PLT) storage performance is consistent by donor. Differences involved metabolic activity, which might be caused by mitochondrial (dys)function, associated with age and age-related diseases like Type 2 diabetes (T2D). We aimed to test PLTs from young donors in comparison with PLTs from older donors with or without diagnosis for T2D. Read More

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December 2018

Engagement of Fas differentially regulates the production of LPS-induced pro-inflammatory cytokines and type I Interferons.

FEBS J 2018 Dec 11. Epub 2018 Dec 11.

Departments of Pathology, University College Cork, Cork, Ireland.

Fas (CD95) signalling is best known for its role in apoptosis, however, recent reports have shown it to be involved in other cellular responses as well, including inflammation. Fas and its adaptor protein FADD are known to negatively regulate LPS-induced pro-inflammatory responses, but their role in LPS-induced type I Interferon production is unknown. Here, we demonstrate that Fas engagement on macrophages, using an agonistic Fas antibody CH11, augments LPS-induced NF-κB responses, causing increased production of TNFα, IL-8, IL-6 and IL-12. Read More

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December 2018

AHNS series: Do you know your guidelines? Guideline recommendations for recurrent and persistent head and neck cancer after primary treatment.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Department of Otolaryngology - Head & Neck Surgery, Division of Head & Neck Oncology, University of Toronto, Sunnybrook Health Sciences and the Odette Cancer Centre, Michael Garron Hospital, Toronto, Ontario, Canada.

Locoregional recurrent/persistent head and neck cancer following primary treatment is a significant challenge as it is usually difficult to treat and has worse outcomes compared to the primary setting. Surgical resection of a local or regional recurrence offers the best chance of cure when feasible. Local recurrence outcomes vary by subsite with laryngeal recurrences having the best prognoses and hypopharynx having the worst. Read More

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December 2018

Dosimetric Features-Driven Machine Learning Model for DVHs Prediction in VMAT Treatment Planning.

Med Phys 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiation Oncology, Stanford University, 875 Blake Wilbur Drive, Stanford, CA, 94305-5847, USA.

Purpose: Few features characterizing the dosimetric properties of the patients are included in currently available dose-volume histogram (DVH) prediction models, making it intractable to build a correlative relationship between the input and output parameters. Here we use PTV-only treatment plans of the patients (i.e. Read More

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December 2018

Incidence of severe critical events in paediatric anaesthesia in the United Kingdom: secondary analysis of the anaesthesia practice in children observational trial (APRICOT study).

Anaesthesia 2018 Dec 10. Epub 2018 Dec 10.

Department of Paediatric Anaesthesia and Pain Management, University of Glasgow, Glasgow, Scotland, UK.

The anaesthesia practice in children observational trial of 31,127 patients in 261 European hospitals revealed a high (5.2%) incidence of severe critical events in the peri-operative period and wide variability in practice. A sub-analysis of the UK data was undertaken to investigate differences compared with the non-UK cohort in the incidence and nature of peri-operative severe critical events and to attempt to identify areas for quality improvement. Read More

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December 2018

The temporomandibular joint: pneumatic temporal cells open into the articular and extradural spaces.

Folia Morphol (Warsz) 2018 Dec 11. Epub 2018 Dec 11.

The pneumatization of the articular tubercle (PAT) of the temporal squama is a rare condition that modifies the barrier between the temporomandibular joint (TMJ) space and the middle cranial fossa. During a routine examination of the cone beam computed tomography (CBCT) files of patients who were scanned for dental medical purposes, we identified a case with multiple rare anatomic variations. First, the petrous apex was bilaterally pneumatized. Read More

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December 2018

The Role of Culture of Origin on the Effectiveness of a Parents-Involved Intervention to Prevent Substance Use Among Latino Middle School Youth: Results of a Cluster Randomized Controlled Trial.

Prev Sci 2018 Dec 8. Epub 2018 Dec 8.

Global Center for Applied Health Research (GCAHR), Arizona State University, Phoenix, AZ, USA.

The purpose of this study was to assess the combined effectiveness of a parenting intervention, Families Preparing the New Generation (FPNG), and a youth curriculum, keepin' it REAL (kiR), on substance use prevention for middle school students in a large urban metro area of the southwest USA. The study aimed to generate usable knowledge on what works in adolescent substance use prevention and how it works best-a combined parent and youth programming or parent-only programming. A total of 532 adolescents in the 7th grade from 19 participating middle schools were randomly assigned into three intervention conditions: parent-youth (PY), parent-only (PO), and comparison (C). Read More

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December 2018

Traumatic Injury.

Exp Suppl 2018 ;108:85-110

Department of Psychiatry and Psychotherapy, University Medicine Mainz, Mainz, Germany.

Traumatic injury as one of the world's most relevant but neglected health concerns results in modulated inflammasome activity, which is closely linked to the development of post-injury complications. Cytokine-producing capacity of cells is important for the appropriate immune response to trauma and requires not only synthesis and transcription of inflammasome components but also their activation. Unfortunately, the precise role of inflammasome in trauma is still largely unknown. Read More

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January 2018
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A new approach to classify and rank events based videos based on Event of Detection.

J Med Syst 2018 Dec 7;43(1):13. Epub 2018 Dec 7.

Department of ECE, Knowledge Institute of Technology, Kakapalayam, Tamil Nadu, India.

In the ongoing days, the development of sight and sound substance and information stockpiling produces colossally. Clients can extricate any kind of data they require from recordings. This outcomes in quick development of video information, client's discover complexity while procurement their important data. Read More

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December 2018

Production of laccase by repeated batch semi-solid fermentation using wheat straw as substrate and support for fungal growth.

Bioprocess Biosyst Eng 2018 Dec 8. Epub 2018 Dec 8.

Department of Biotechnology, Dr. B. R. Ambedkar National Institute of Technology, G T Road Bye Pass, Jalandhar, 144011, India.

Repeated batch semi-solid fermentation (sSF) process using wheat straw substrate and fungal growth of Ganoderma lucidum on solid substrate was studied for production of laccase. pH showed significant effect on laccase production. Highest laccase activity with pH controlled to 5. Read More

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December 2018

Effects of supplementing herbaceous forage legume pellets on growth indices and blood profile of West African dwarf sheep fed Guinea grass.

Trop Anim Health Prod 2018 Dec 7. Epub 2018 Dec 7.

Department of Pasture and Range Management, Federal University of Agriculture, Abeokuta, P. M. B. 2240, Nigeria.

Twenty West African dwarf (WAD) rams with average body weight of 12.43 ± 0.5 kg were used for the experiment that lasted 84 days to investigate the effects of supplementing herbaceous forage legume pellets on weight change and blood profile of animals fed Panicum maximum basal diet. Read More

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December 2018

A new semi-automated workflow for chemical data retrieval and quality checking for modeling applications.

J Cheminform 2018 Dec 10;10(1):60. Epub 2018 Dec 10.

Laboratory of Environmental Chemistry and Toxicology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via la Masa 19, 20156, Milan, Italy.

The quality of data used for QSAR model derivation is extremely important as it strongly affects the final robustness and predictive power of the model. Ambiguous or wrong structures need to be carefully checked, because they lead to errors in calculation of descriptors, hence leading to meaningless results. The increasing amounts of data, however, have often made it hard to check of very large databases manually. Read More

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December 2018

[Diagnostic and therapeutic considerations on recurrence of multiple myeloma : A current overview].

Internist (Berl) 2018 Dec 10. Epub 2018 Dec 10.

Medizinische Klinik 2, Universitätsklinikum Würzburg, Oberdürrbacher Str. 6, 97074, Würzburg, Deutschland.

The treatment of multiple myeloma remains in a state of profound change. Over the past decades both disease-free survival and overall survival have been significantly prolonged by the approval of new drugs; however, despite high response rates and achievement of deep responses to primary treatment, recurrence of the disease is still expected in nearly all patients treated. Fortunately, good treatment options for myeloma patients in relapse are also currently available and the possible combinations of approved substances are numerous. Read More

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December 2018
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Vascular remodeling of choroidal neovascularization in older myopic patients treated with ranibizumab.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Hôpital Avicenne, AP-HP and Paris 13 University, Bobigny, France.

Purpose: To investigate morphological changes in myopic choroidal neovascularization (mCNV) using optical coherence tomography-angiography (OCT-A) after treatment with ranibizumab.

Methods: Retrospective analysis of consecutive patients over a 24-month period. All treatment-naïve mCNV were imaged at baseline with color pictures, spectral-domain OCT and OCT-A, and fluorescein angiography in selected cases. Read More

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December 2018

Visual acuity in patients with keratoconus: a comparison with matched regular myopic astigmatism.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Barzilai Medical Center, Ashkelon and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheba, Israel.

Purpose: To compare uncorrected distance visual acuity (UDVA) and best-corrected distance visual acuity (CDVA) between patients with keratoconus (KC) and matched patients with regular myopic astigmatism.

Methods: This retrospective study included consecutive patients diagnosed with KC between 2008 and 2013 at Care-Vision Laser Centers, Tel-Aviv, Israel, and matched patients with regular myopic astigmatism. Data included were central corneal thickness (CCT), spherical equivalent (SE), cylinder (CYL), mean keratometric power, maximum keratometric power (K), UDVA, CDVA, and defocus equivalent (DEQ). Read More

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December 2018

Overall Survival of Primary Intracranial Atypical Teratoid Rhabdoid Tumor Following Multimodal Treatment: A Pooled Analysis of Individual Patient Data.

Neurosurg Rev 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Tiantan Xili 6, Dongcheng District, Beijing, People's Republic of China.

No standard treatment protocol to guide the management of the primary central nervous system atypical teratoid rhabdoid tumors (ATRTs). To evaluate the efficacy of GTR (gross total resection), RT (radiotherapy), CCMT (conventional chemotherapy), or intensified chemotherapy (ICMT) and verify the optimal treatment strategy. A total of 501 cases (18 cases from our center and 483 cases from published literature) were eligible for analysis. Read More

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December 2018

Oligosaccharides as co-encapsulating agents: effect on oral Lactobacillus fermentum survival in a simulated gastrointestinal tract.

Biotechnol Lett 2018 Dec 10. Epub 2018 Dec 10.

School of Food Science and Technology, Jiangnan University, Jiangsu, People's Republic of China.

Objectives: Four kinds of oligosaccharides were used as co-encapsulating agents to test the effect of extrusion-based microencapsulation on protection of Lactobacillus fermentum L7 against exposure to simulated gastric and intestinal juices as well as long-term refrigeration storage at 4 °C.

Results: The combination of alginate with galacto-oligosaccharides, isomalto-oligosaccharides, fructo-oligosaccharides, and xylo-oligosaccharides, or alginate alone exhibited good properties of the beads. The diameters of the cell beads co-encapsulated with oligosaccharides and encapsulated with alginate alone were similar, in the range of 2. Read More

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December 2018
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Hearing preservation in small acoustic neuroma: observation or active therapy? Literature review and institutional experience.

Acta Neurochir (Wien) 2018 Dec 8. Epub 2018 Dec 8.

Academic Neurosurgery, Department of Neurosciences, University Hospital of Padova, Via Giustiniani 2, 35128, Padova, Italy.

Background: Current imaging modalities enable early diagnosis of a large number of small acoustic neuromas in patients with well-preserved hearing, whose best management is still a debatable matter.

Methods: Comparing the hearing outcome of the various therapeutical approaches, including observation, radiosurgery, or resective surgery, is not easy because of the numerous classifications measuring hearing in different ways. In this review, a literature review was performed and papers selected dealing with small tumors, short- and long-term hearing, tumor control or radical resection, and effect of pre-treatment hearing and size on outcome. Read More

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December 2018

Effect of brightness and contrast variation for detectability of root resorption lesions in digital intraoral radiographs.

Clin Oral Investig 2018 Dec 7. Epub 2018 Dec 7.

Department of Oral Diagnosis, Division of Oral Radiology, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Piracicaba, Sao Paulo, 13414-903, Brazil.

Objectives: To evaluate the performance of periapical radiography assessed under different radiographic brightness and contrast variations in the detection of simulated internal (IRR) and external (ERR) root resorption lesions. Additionally, observers' preferences related to image quality for these diagnostic tasks were evaluated.

Methods: Thirty single-root teeth were divided into two groups (n = 15): IRR, in which lesions were simulated using mechanical and biochemical processes; and ERR, in which cavities standardized with drills of different sizes were performed on the root surfaces. Read More

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December 2018
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EQ-5D-5L Valuation for the Malaysian Population.

Pharmacoeconomics 2018 Dec 11. Epub 2018 Dec 11.

Pharmacy Practice and Development Division, Ministry of Health Malaysia, Selangor, Malaysia.

Objectives: The aim of this study was to develop an EQ-5D-5L value set reflecting the health preferences of the Malaysian adult population.

Methods: Respondents were sampled with quotas for urbanicity, gender, age, and ethnicity to ensure representativeness of the Malaysian population. The study was conducted using a standardized protocol involving the EuroQol Valuation Technology (EQ-VT) computer-assisted interview system. Read More

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December 2018

External validation of a combined PET and MRI radiomics model for prediction of recurrence in cervical cancer patients treated with chemoradiotherapy.

Eur J Nucl Med Mol Imaging 2018 Dec 7. Epub 2018 Dec 7.

Radiation Oncology Department, University Hospital, Brest, France.

Purpose: The aim of this study was to validate previously developed radiomics models relying on just two radiomics features from F-fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) images for prediction of disease free survival (DFS) and locoregional control (LRC) in locally advanced cervical cancer (LACC).

Methods: Patients with LACC receiving chemoradiotherapy were enrolled in two French and one Canadian center. Pre-treatment imaging was performed for each patient. Read More

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December 2018

Modelled Economic Evaluation of Nivolumab for the Treatment of Second-Line Advanced or Metastatic Squamous Non-Small-Cell Lung Cancer in Australia Using Both Partition Survival and Markov Models.

Appl Health Econ Health Policy 2018 Dec 10. Epub 2018 Dec 10.

Discipline of Pharmacy and Experimental Pharmacology, School of Biomedical Sciences and Pharmacy, Faculty of Medicine and Health, The University of Newcastle, MS108, Medical Sciences Building, University Drive, Callaghan, 2308, NSW, Australia.

Objectives: To assess the cost-effectiveness of nivolumab for patients with advanced or metastatic squamous non-small-cell lung cancer (NSCLC) progressed on or after platinum-based chemotherapy using a modelled economic evaluation.

Methods: Both partition survival (PS) and Markov models, comprised of three health states, were adopted to evaluate the cost-effectiveness of nivolumab compared to docetaxel from an Australian healthcare system perspective with a 6-year time horizon. Reconstructed individual patient data (IPD) were derived from published Kaplan-Meier curves from the pivotal trial for overall survival (OS) and progression-free survival (PFS) using a validated algorithm. Read More

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December 2018

Communication and comprehensive cancer control coalitions: lessons from two decades of campaigns, outreach, and training.

Cancer Causes Control 2018 Dec 10. Epub 2018 Dec 10.

Department of Kinesiology and Health Education, The University of Texas at Austin, 2109 San Jacinto Blvd. (D3700), Austin, TX, 78712-1415, USA.

Purpose: Comprehensive cancer control (CCC) coalitions and programs have delivered effective models and approaches to reducing cancer burden across the United States over the last two decades. Communication plays an essential role in diverse coalition activities from prevention to survivorship, including organizational and community capacity-building and as cancer control intervention strategies.

Methods: Based upon a review of published CCC research as well as public health communication best practices, this article describes lessons learned to assist CCC coalitions and programs with systematic implementation of communication efforts as key strategies in cancer control. Read More

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December 2018
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Mapping terrestrial oil spill impact using machine learning random forest and Landsat 8 OLI imagery: a case site within the Niger Delta region of Nigeria.

Environ Sci Pollut Res Int 2018 Dec 7. Epub 2018 Dec 7.

Department of Geography, University of Leicester, Leicester, United Kingdom.

Terrestrial oil pollution is one of the major causes of ecological damage within the Niger Delta region of Nigeria and has caused a considerable loss of mangroves and arable croplands since the discovery of crude oil in 1956. The exact extent of landcover loss due to oil pollution remains uncertain due to the variability in factors such as volume and size of the oil spills, the age of oil, and its effects on the different vegetation types. Here, the feasibility of identifying oil-impacted land in the Niger Delta region of Nigeria with a machine learning random forest classifier using Landsat 8 (OLI spectral bands) and Vegetation Health Indices is explored. Read More

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December 2018

A carbon paste electrode modified with a nickel titanate nanoceramic for simultaneous voltammetric determination of ortho- and para-hydroxybenzoic acids.

Mikrochim Acta 2018 Dec 10;186(1):12. Epub 2018 Dec 10.

Department of Chemistry, Islamic Azad University, Naragh Branch, Naragh, Iran.

An electrochemical sensor is described for the simultaneous determination of ortho-hydroxybenzoic acid (OHB) and para-hydroxybenzoic acid (PHB). The sensor consists of a carbon paste electrode modified with nickel titanate nanoceramics (NiTiO/CPE). The NiTiO nanoceramics and the nanostructured modified CPE were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, electrochemical impedance spectroscopy and cyclic voltammetry. Read More

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December 2018
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