178,223 results match your criteria Best Practice & Research: Clinical Haematology[Journal]


Targeted Medical School Admissions: A Strategic Process for Meeting Our Social Mission.

Fam Med 2020 Jun;52(7):474-482

Department of Family Medicine, University of Washington School of Medicine, Seattle, WA.

Background And Objectives: Increased medical school class sizes and new medical schools have not addressed the workforce inadequacies in primary care or underserved settings. While there is substantial evidence that student attributes predict practice specialty and location, little is known about how schools use these factors in admissions processes. We sought to describe admissions strategies to recruit students likely to practice in primary care or underserved settings. Read More

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http://dx.doi.org/10.22454/FamMed.2020.470334DOI Listing

Consensus Recommendations on the Prehospital Care of the Injured Athlete With a Suspected Catastrophic Cervical Spine Injury.

Clin J Sport Med 2020 Jul;30(4):296-304

University of Georgia, Athens, Georgia.

Introduction: Sports participation is among the leading causes of catastrophic cervical spine injury (CSI) in the United States. Appropriate prehospital care for athletes with suspected CSIs should be available at all levels of sport. The goal of this project was to develop a set of best-practice recommendations appropriate for athletic trainers, emergency responders, sports medicine and emergency physicians, and others engaged in caring for athletes with suspected CSIs. Read More

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http://dx.doi.org/10.1097/JSM.0000000000000869DOI Listing

Electrocardiographic voltage criteria in patients with hypertrophic cardiomyopathy.

J Cardiovasc Med (Hagerstown) 2020 Jul 6. Epub 2020 Jul 6.

Department of Cardiology, Policlinico Casilino.

Background: Several ECG voltage criteria have been proposed for the diagnosis of left ventricular hypertrophy (LVH). Notably, ECG criteria have been historically validated in concentric LVH but not in hypertrophic cardiomyopathy (HCM), wherein the hypertrophy pattern is typically asymmetric.

Objectives: The aim of our study was to evaluate the performance of ECG voltage criteria for LVH diagnosis in the HCM population. Read More

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http://dx.doi.org/10.2459/JCM.0000000000001034DOI Listing

Mucosal bacterial vaccines in clinical practice - a novel approach to an old problem?

Rev Assoc Med Bras (1992) 2020 May 3;66(5):659-665. Epub 2020 Jul 3.

Unidade de Pneumologia, Universidade e Centro Hospitalar de Coimbra, Coimbra, Portugal.

OBJECTIVES To evaluate the efficacy of mucosal bacterial vaccines (MBV) in reducing the number of exacerbations in patients with chronic respiratory disease. METHODS A prospective cohort study of patients followed at the Pneumology Unit of the University and Hospital Centre of Coimbra, with frequent infectious exacerbations (3 or more) despite the best therapeutic strategies employed. MBV was used as additional therapy. Read More

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http://dx.doi.org/10.1590/1806-9282.66.5.659DOI Listing

The use of functional performance tests and simple anthropomorphic measures to screen for comorbidity in primary care.

Int J Older People Nurs 2020 Jul 7:e12333. Epub 2020 Jul 7.

School of Nursing, The Hong Kong Polytechnic University, Kowloon, Hong Kong.

Background: Many older adults are unaware that they have comorbid diseases. Increased adiposity and reduced muscle mass are identified as key contributors to many chronic diseases in older adults. Understanding the role they play in the development of comorbidities in older populations is of prime importance. Read More

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http://dx.doi.org/10.1111/opn.12333DOI Listing

The practice of oral and maxillofacial radiology during COVID-19 outbreak.

Oral Radiol 2020 Jul 7. Epub 2020 Jul 7.

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

The current coronavirus disease 2019 (COVID-19) outbreak has brought substantial challenges to the world health system, including the practice of dental and maxillofacial radiology (DMFR). DMFR will carry on an imperative role in healthcare during this crisis. This rapid communication has collected and evaluated all the best current evidence and published guidelines as well as professional recommendations to help maxillofacial radiologists and dental practitioners for safer radiological and imaging examinations on healthy, suspected, or confirmed COVID-19 patients during outbreak. Read More

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http://dx.doi.org/10.1007/s11282-020-00465-8DOI Listing

Current State of Transgender Medical Education in the United States and Canada: Update to a Scoping Review.

J Med Educ Curric Dev 2020 Jan-Dec;7:2382120520934813. Epub 2020 Jun 24.

Division of Plastic Surgery, Department of Surgery, University of Washington School of Medicine, Seattle, WA, USA.

Background: The published literature on education about transgender health within health professions curricula was previously found to be sporadic and fragmented. Recently, more inclusive and holistic approaches have been adopted. We summarize advances in transgender health education. Read More

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http://dx.doi.org/10.1177/2382120520934813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315660PMC

Treatment After Anterior Cruciate Ligament Injury: Panther Symposium ACL Treatment Consensus Group.

Orthop J Sports Med 2020 Jun 24;8(6):2325967120931097. Epub 2020 Jun 24.

Investigation performed at University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Treatment strategies for anterior cruciate ligament (ACL) injuries continue to evolve. Evidence supporting best-practice guidelines for the management of ACL injury is to a large extent based on studies with low-level evidence. An international consensus group of experts was convened to collaboratively advance toward consensus opinions regarding the best available evidence on operative versus nonoperative treatment for ACL injury. Read More

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http://dx.doi.org/10.1177/2325967120931097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315684PMC

Sodium-Glucose Cotransporter-2 Inhibitors in Nephrology Practice: A Narrative Review.

Can J Kidney Health Dis 2020 24;7:2054358120935701. Epub 2020 Jun 24.

Toronto General Hospital Research Institute, UHN, Toronto, ON, Canada.

Purpose Of The Review: Sodium-glucose cotransporter-2 inhibitors (SGLT2is) are recommended for eligible patients with type 2 diabetes for the secondary prevention of adverse cardiovascular and kidney disease outcomes. Patients with type 2 diabetes and albuminuric chronic kidney disease, a history of atherosclerotic cardiovascular disease, and/or heart failure with reduced ejection fraction should be assessed for the use of these therapies.

Sources Of Information: The sources include published clinical trials with SGLT2is, with a focus on cardiovascular safety studies and kidney protection trials. Read More

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http://dx.doi.org/10.1177/2054358120935701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315675PMC

Single-cell ATAC sequencing analysis: From data preprocessing to hypothesis generation.

Comput Struct Biotechnol J 2020 12;18:1429-1439. Epub 2020 Jun 12.

Department of Biotechnology, College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea.

Most genetic variations associated with human complex traits are located in non-coding genomic regions. Therefore, understanding the genotype-to-phenotype axis requires a comprehensive catalog of functional non-coding genomic elements, most of which are involved in epigenetic regulation of gene expression. Genome-wide maps of open chromatin regions can facilitate functional analysis of cis- and trans-regulatory elements via their connections with trait-associated sequence variants. Read More

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http://dx.doi.org/10.1016/j.csbj.2020.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327298PMC

High Incidence of Burst Suppression during Propofol Sedation for Outpatient Colonoscopy: Lessons Learned from Neuromonitoring.

Anesthesiol Res Pract 2020 19;2020:7246570. Epub 2020 Jun 19.

Department of Anesthesiology, Division of Neurological Anesthesia, Thomas Jefferson University, 111 S. 11 Street, Philadelphia, PA 19107, USA.

Background: Although anesthesia providers may plan for moderate sedation, the depth of sedation is rarely quantified. Using processed electroencephalography (EEG) to assess the depth of sedation, this study investigates the incidence of general anesthesia with variable burst suppression in patients receiving propofol for outpatient colonoscopy. The lessons learned from neuromonitoring can then be used to guide institutional best sedation practice. Read More

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http://dx.doi.org/10.1155/2020/7246570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321500PMC

Evaluating a specialist primary care service for patients experiencing homelessness: a qualitative study.

BJGP Open 2020 Jul 7. Epub 2020 Jul 7.

Norwich Medical School, University of East Anglia, Norwich, UK.

Background: People experiencing homelessness (PEH) often experience poor health, multimorbidity, and early mortality and experience barriers to accessing high quality health care. Little is known about how best to provide specialist primary care for these patients.

Aim: To evaluate the health care provided to patients experiencing homelessness who were seen in a specialist primary care service. Read More

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http://dx.doi.org/10.3399/bjgpopen20X101049DOI Listing

Is there a standardised consent process within the surgical specialties?

Surgeon 2020 Jul 5. Epub 2020 Jul 5.

Department of General and Colorectal Surgery, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, UK.

Introduction: The consent process is central to surgical practice. Subsequent to landmark cases such as Montgomery and Thefaut there is increasing consensus that consent should be a staged process. The aim of our survey was to identify if there was any homogeneity in the practice of surgeons with regards to the consent process in comparison to national guidelines. Read More

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http://dx.doi.org/10.1016/j.surge.2020.06.004DOI Listing

Impact of Genetically Predicted Red Blood Cell Traits on Venous Thromboembolism: Multivariable Mendelian Randomization Study Using UK Biobank.

J Am Heart Assoc 2020 Jul 8:e016771. Epub 2020 Jul 8.

School of Public Health Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR, China.

Background Red blood cell (RBC) transfusion and erythropoiesis-stimulating agent administration are cornerstones of clinical practice, yet concerns exist as to potential increased risk of thrombotic events. This study aims to identify RBC traits most relevant to venous thromboembolism (VTE) and assess their genetically predicted effects on VTE in the general population. Methods and Results We used multivariable mendelian randomization with bayesian model averaging for exposure selection. Read More

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http://dx.doi.org/10.1161/JAHA.120.016771DOI Listing

European consensus recommendations for neonatal and paediatric retrievals of positive or suspected COVID-19 patients.

Pediatr Res 2020 Jul 7. Epub 2020 Jul 7.

Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.

Background: The 2020 novel coronavirus (SARS-Cov-2) pandemic necessitates tailored recommendations addressing specific procedures for neonatal and paediatric transport of suspected or positive COVID-19 patients. The aim of this consensus statement is to define guidelines for safe clinical care for children needing inter-facility transport while making sure that the clinical teams involved are sufficiently protected from SARS-CoV-2.

Methods: A taskforce, composed of members of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC) Transport section and the European Society for Paediatric Research (ESPR), reviewed the published literature and used a rapid, two-step modified Delphi process to formulate recommendations regarding safety and clinical management during transport of COVID-19 patients. Read More

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http://dx.doi.org/10.1038/s41390-020-1050-zDOI Listing

Current Practices for Screening and Management of Financial Distress at NCCN Member Institutions.

J Natl Compr Canc Netw 2020 Jul;18(7):825-831

3Fred Hutchinson Cancer Research Center, University of Washington Children's Hospital, Seattle, Washington.

Background: Financial distress from medical treatment is an increasing concern. Healthcare organizations may have different levels of organizational commitment, existing programs, and expected outcomes of screening and management of patient financial distress.

Patients And Methods: In November 2018, representatives from 17 (63%) of the 27 existing NCCN Member Institutions completed an online survey. Read More

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http://dx.doi.org/10.6004/jnccn.2020.7538DOI Listing

Results from the Netherlands' 2018 Report Card and Report Card on physical activity for children and youth with and without chronic medical condition.

Public Health 2020 Jul 4;185:161-166. Epub 2020 Jul 4.

Dutch National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Objective: The objective of this study was to summarize the results of the 2018 the Netherlands' Physical Activity Report Card (PARC) for children and youth as well as for children and youth with a chronic medical condition (CMC; PARC).

Study Design: This study is a survey.

Methods: A total of 12 indicators were graded using the Active Healthy Kids Global Alliance PARC development process, which includes a synthesis of the best available research, surveillance, policy and practice findings and expert consensus. Read More

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http://dx.doi.org/10.1016/j.puhe.2020.04.044DOI Listing

Determinants of physicians' attitudes toward the management of infectious diseases in terminally-ill patients with cancer.

J Pain Symptom Manage 2020 Jul 4. Epub 2020 Jul 4.

Palliative Care Team, Seirei Mikatahara General Hospital, Hamamatsu, Shizuoka, Japan.

Background: Antimicrobials are frequently prescribed to terminally-ill patients with cancer; however, physicians' practice patterns regarding antimicrobial use vary widely. This study aimed to systematically identify factors that determine physicians' attitudes toward the management of infectious diseases in terminally-ill patients with cancer.

Methods: A nationwide cross-sectional survey involving 600 oncologists, 600 infectious diseases physicians, 600 palliative care physicians, and 220 home care physicians was conducted between November 2017 and January 2018. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2020.06.041DOI Listing

Diagnostic parameters of modified two-tier testing in European patients with early Lyme disease.

Eur J Clin Microbiol Infect Dis 2020 Jul 6. Epub 2020 Jul 6.

Department of Medical Microbiology, OLVG, Amsterdam, the Netherlands.

Modified two-tier testing (MTTT) for Lyme borreliosis (i.e. confirmation with an EIA instead of an immunoblot) has been shown to have improved sensitivity compared with standard two-tier testing (STTT) in samples from American patients, without losing specificity. Read More

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http://dx.doi.org/10.1007/s10096-020-03946-0DOI Listing

Adaptation of public health initiatives: expert views on current guidance and opportunities to advance their application and benefit.

Health Educ Res 2020 Jul 6. Epub 2020 Jul 6.

School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.

While there is some guidance to support the adaptation of evidence-based public health interventions, little is known about adaptation in practice and how to best support public health practitioners in its operationalization. This qualitative study was undertaken with researchers, methodologists, policy makers and practitioners representing public health expert organizations and universities internationally to explore their views on available adaptation frameworks, elicit potential improvements to such guidance, and identify opportunities to improve implementation of public health initiatives. Participants attended a face to face workshop in Newcastle, Australia in October 2018 where World Café and focus group discussions using Appreciative Inquiry were undertaken. Read More

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http://dx.doi.org/10.1093/her/cyaa014DOI Listing

Writing autohistoria-teoría: agency and illness in German life narratives by Evelyne Leandro and Mely Kiyak.

Authors:
Katja Herges

Med Humanit 2020 Jul 6. Epub 2020 Jul 6.

Psychosomatic Medicine and Psychotherapy, University Hospital Tuebingen, Tuebingen, Germany

Health concerns by migrants have been neglected in the German healthcare system, and they are impacted by discriminating discourses of othering. By analysing two autobiographical illness narratives by immigrants in contemporary Germany, this article exposes limitations in existing discourses of migration health and argues for more relational and affirmative theories of illness and care. Evelyn Leandro's diary The Living Death: The Struggle with a Long-Forgotten Illness (2017) describes her own drawn-out therapy against leprosy as a Brazilian in Berlin. Read More

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http://dx.doi.org/10.1136/medhum-2019-011746DOI Listing

ARTP statement on pulmonary function testing 2020.

BMJ Open Respir Res 2020 Jul;7(1)

Department of Respiratory Medicine, Dorset County Hospital NHS Foundation Trust, Dorchester, Dorset, UK.

The Association for Respiratory Technology & Physiology (ARTP) last produced a statement on the performance of lung function testing in 1994. At that time the focus was on a practical statement for people working in lung function laboratories. Since that time there have been many technological advances and alterations to best practice in the measurement and interpretation of lung function assessments. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000575DOI Listing

Antibiotics and Inflatable Penile Prosthesis Insertion: A Literature Review.

Sex Med Rev 2020 Jul 3. Epub 2020 Jul 3.

Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA.

Introduction: Antibiotic stewardship is now a priority for the urologic community. Perioperative antibiotic use at the time of inflatable penile prosthesis (IPP) insertion has become a topic of interest.

Objectives: To review the literature available to inform the practice of antibiotic administration before, during, and after IPP insertion. Read More

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http://dx.doi.org/10.1016/j.sxmr.2020.04.005DOI Listing

Impact of a Hybrid Lung Cancer Screening Model on Patient Outcomes and Provider Behavior.

Clin Lung Cancer 2020 May 23. Epub 2020 May 23.

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO; Sacred Heart Medical Center, Spokane, WA. Electronic address:

Background: Lung cancer screening (LCS) implementation is complicated by the Centers for Medicare and Medicaid Services reimbursement requirements of shared decision-making and tobacco cessation counseling. LCS programs can utilize different structures to meet these requirements, but the impact of programmatic structure on provider behavior and screening outcomes is poorly described.

Patients And Methods: In a retrospective chart review of 624 patients in a hybrid structure, academic LCS program, we compared characteristics and outcomes of primary care provider (PCP)- and specialist-screened patients. Read More

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http://dx.doi.org/10.1016/j.cllc.2020.05.018DOI Listing

Observation of Emergency Room Nurses Managing Pediatric Pain: Care to Be Given… Care Given….

Pain Manag Nurs 2020 Jul 3. Epub 2020 Jul 3.

Université de Sherbrooke, Faculté de médecine et des sciences de la santé, Sherbrooke, Quebec, Canada; CIUSSS-Estrie CHUS, University Hospital Sherbrooke, Quebec, Canada.

Background: Although pain undeniably has negative consequences, pain management often remains suboptimal, particularly in the pediatric population in the emergency room (ER).

Aim: In this observational study using qualitative and quantitative methods, we investigated everyday adherence to current nursing best-practice pediatric guidelines in the ER paying particular attention to the interaction between children, parents, and nurses.

Methods: An adapted version of the nursing observation tool for pain management was used to describe pediatric pain management provided by nurses caring for children (0-14 years old) admitted to the ER. Read More

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http://dx.doi.org/10.1016/j.pmn.2020.03.002DOI Listing

Effects of intraoperative individualized PEEP on postoperative atelectasis in obese patients: study protocol for a prospective randomized controlled trial.

Trials 2020 Jul 6;21(1):618. Epub 2020 Jul 6.

Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Road, Xicheng District, Beijing, 100050, China.

Background: Obese patients undergoing general anesthesia and mechanical ventilation during laparoscopic abdominal surgery commonly have a higher incidence of postoperative pulmonary complications (PPCs), due to factors such as decreasing oxygen reserve, declining functional residual capacity, and reducing lung compliance. Pulmonary atelectasis caused by pneumoperitoneum and mechanical ventilation is further aggravated in obese patients. Recent studies demonstrated that individualized positive end-expiratory pressure (iPEEP) was one of effective lung-protective ventilation strategies. Read More

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http://dx.doi.org/10.1186/s13063-020-04565-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338115PMC

Guidance concerning chiropractic practice in response to COVID-19 in the U.S.: a summary of state regulators' web-based information.

Chiropr Man Therap 2020 07 6;28(1):44. Epub 2020 Jul 6.

Veterans Affairs Northern California Health Care System, Redding, CA, USA.

Introduction: The COVID-19 pandemic led to unprecedented changes, as many state and local governments enacted stay-at-home orders and non-essential businesses were closed. State chiropractic licensing boards play an important role in protecting the public via regulation of licensure and provision of guidance regarding standards of practice, especially during times of change or uncertainty.

Objective: The purpose of this study was to summarize the guidance provided in each of the 50 United States, related to chiropractic practice during the COVID-19 pandemic. Read More

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http://dx.doi.org/10.1186/s12998-020-00333-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336092PMC

The value of social practice theory for implementation science: learning from a theory-based mixed methods process evaluation of a randomised controlled trial.

BMC Med Res Methodol 2020 Jul 6;20(1):181. Epub 2020 Jul 6.

Health Services Research, Institute of Health Research, University of Exeter College of Medicine and Health, St Luke's Campus, Heavitree Road, Exeter, Devon, EX1 2LU, UK.

Background: Although there is trial evidence that complex interventions are effective for the self-management of heart failure, little evidence supports their effectiveness in routine practice. We used Social Practice Theory to guide a Type 1 Hybrid Trial: a mixed methods process evaluation of a complex intervention for heart failure. The objective of this paper is to explore the value of Social Practice Theory for implementation science. Read More

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http://dx.doi.org/10.1186/s12874-020-01060-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336630PMC

The Percentage of Free PSA and Urinary Markers Distinguish Prostate Cancer from Benign Hyperplasia and Contribute to a More Accurate Indication for Prostate Biopsy.

Biomedicines 2020 Jun 25;8(6). Epub 2020 Jun 25.

Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, 779 00 Olomouc, Czech Republic.

The main advantage of urinary biomarkers is their noninvasive character and the ability to detect multifocal prostate cancer (CaP). We have previously implemented a quadruplex assay of urinary markers into clinical practice ( and with normalization). In this study, we aimed to validate it in a larger cohort with serum PSA 2. Read More

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http://dx.doi.org/10.3390/biomedicines8060173DOI Listing

Average Consensus over Mobile Wireless Sensor Networks: Weight Matrix Guaranteeing Convergence without Reconfiguration of Edge Weights.

Sensors (Basel) 2020 Jun 30;20(13). Epub 2020 Jun 30.

Sipwise GmbH, Europaring F15, 2345 Brunn am Gebirge, Austria.

Efficient data aggregation is crucial for mobile wireless sensor networks, as their resources are significantly constrained. Over recent years, the average consensus algorithm has found a wide application in this technology. In this paper, we present a weight matrix simplifying the average consensus algorithm over mobile wireless sensor networks, thereby prolonging the network lifetime as well as ensuring the proper operation of the algorithm. Read More

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http://dx.doi.org/10.3390/s20133677DOI Listing

Growth Assessment in Preterm Children from Birth to Preschool Age.

Nutrients 2020 Jun 30;12(7). Epub 2020 Jun 30.

Early Infancy Special Care Unit, Regina Margherita Children Hospital, A.O.U. Città della Salute e della Scienza di Torino, 10126 Torino, Italy.

Preterm infant growth is a major health indicator and needs to be monitored with an appropriate growth curve to achieve the best developmental and growth potential while avoiding excessive caloric intake that is linked to metabolic syndrome and hypertension later in life. New international standards for size at birth and postnatal growth for preterm infants are available and need implementation in clinical practice. A prospective, single center observational study was conducted to evaluate the in-hospital and long-term growth of 80 preterm infants with a mean gestational age of 33. Read More

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http://dx.doi.org/10.3390/nu12071941DOI Listing

The 5-Ws of immunotherapy in head and neck cancer.

Crit Rev Oncol Hematol 2020 Jun 30;153:103041. Epub 2020 Jun 30.

Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy.

The immune checkpoint inhibitors, a class of drugs able to block immune suppressive pathways in order to prime an anticancer immunity, revolutionized standard of care in platinum-refractory recurrent and/or metastatic head and neck carcinoma (R/M HNSCC). The PD-1/ PD-L1 axis is involved in the genesis, maintenance and progression of HNSCC and represents the target of checkpoint inhibitors. HNSCC is an immunosuppressive disease with a high inflammatory component in tumor microenvironment. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.103041DOI Listing

Clinical Use Of Biologics For Asthma Treatment By Allergy Specialists: A Questionnaire Survey.

Ann Allergy Asthma Immunol 2020 Jul 3. Epub 2020 Jul 3.

University of Cincinnati College of Medicine, Department of Internal Medicine; Division of Immunology/Allergy Section. Electronic address:

Background: Asthma is a heterogeneous disease with emerging phenotypes and endotypes. Currently, five distinct biologics are Food and Drug Administration (FDA)-approved as add-on therapy for difficult-to-control Type 2-high asthma. As allergy specialists manage a spectrum of diseases for which biologics may be appropriate, it is important to understand their prescribing patterns. Read More

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http://dx.doi.org/10.1016/j.anai.2020.06.041DOI Listing

Setting realistic goals for feeding infants when their mothers have suspected or confirmed COVID-19.

Acta Paediatr 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatrics (Neonatal Division), McMaster University, Hamilton, Ontario, Canada.

The pandemic is a stressful time for everyone, including mothers and healthcare providers who are concerned about the best and safest way to feed babies born to mothers with suspected or confirmed COVID-19. There is lack of consensus regarding mother-infant contact, unless the mother definitely has COVID-19 and even then there is a distinct lack of data to devise protocols for everyday clinical practice.. Read More

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http://dx.doi.org/10.1111/apa.15459DOI Listing

Update on evidence in craniomaxillofacial surgery.

Curr Opin Otolaryngol Head Neck Surg 2020 Aug;28(4):241-245

Department of Otolaryngology at SUNY Upstate Medical University, Syracuse, New York, USA.

Purpose Of Review: Evidence-based medicine underpins clinical practice. Ideally, our clinical decision-making stems from systematic reviews of randomized controlled trials. However, in practice, this is not often the case, and we must instead rely on the best available evidence. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000642DOI Listing

Nonoperating room anesthesia for patients with serious comorbidities.

Authors:
Reino Pöyhiä

Curr Opin Anaesthesiol 2020 Aug;33(4):594-600

Department of Anesthesiology and Intensive Care, University of Helsinki, Helsinki, Finland.

Purpose Of Review: To provide aids to deal with increasing amount of several comorbidities in nonoperating room anesthesia (NORA).

Recent Findings: New indexes for assessment of comorbidities are described and guidelines for the care of patients with obesity, obstructive sleep apnea, chronic obstructive pulmonary disease (COPD), diabetes and COVID19 in NORA summarized.

Summary: In addition to ASA classification, such instruments as Charlson Comorbidity Index, Frailty Index, Surgical Complexity Score and Revised Cardiac Risk could supplement the prospective assessment of the risk of comorbidities. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000890DOI Listing

Alcoholics Anonymous and 12-Step Facilitation Treatments for Alcohol Use Disorder: A Distillation of a 2020 Cochrane Review for Clinicians and Policy Makers.

Alcohol Alcohol 2020 Jul 6. Epub 2020 Jul 6.

Veterans Affairs and Stanford University Medical Centers, Stanford University Stanford School of Medicine, Stanford, CA, USA.

Aims: A recently completed Cochrane review assessed the effectiveness and cost-benefits of Alcoholics Anonymous (AA) and clinically delivered 12-Step Facilitation (TSF) interventions for alcohol use disorder (AUD). This paper summarizes key findings and discusses implications for practice and policy.

Methods: Cochrane review methods were followed. Read More

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http://dx.doi.org/10.1093/alcalc/agaa050DOI Listing

Human papillomavirus vaccination: Good clinical practice recommendations from the Federation of Obstetric and Gynecological Societies of India.

J Obstet Gynaecol Res 2020 Jul 6. Epub 2020 Jul 6.

Breach Candy Hospital and Research Centre, Mumbai, India.

Human papillomavirus (HPV) vaccination offers an excellent prospect for the primary prevention of cervical cancer. The bivalent and quadrivalent vaccines are both available in India. The nonavalent vaccine is licensed but not yet available. Read More

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http://dx.doi.org/10.1111/jog.14345DOI Listing
July 2020
0.931 Impact Factor

Congenital Heart Disease Long-term Improvement in Functional hEalth (CHD LIFE): A partnership program to improve the long-term functional health of children with congenital heart disease in Queensland.

J Paediatr Child Health 2020 Jul 6. Epub 2020 Jul 6.

Queensland Children's Hospital, Children's Health Queensland, Brisbane, Queensland, Australia.

Children who undergo open-heart surgery in the first year of life for congenital heart disease (CHD) are at high-risk for impaired development across multiple domains. International recommendations include systematic periodic developmental surveillance into adolescence and the establishment of long-termfollow-up programmes. This article describes the establishment and evolution of the Queensland Paediatric Cardiac Service neurodevelopmental follow-up programme - CHD LIFE (Long-term Improvement in Functional hEalth). Read More

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http://dx.doi.org/10.1111/jpc.14935DOI Listing

Institutional variation in recovery after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: An opportunity for enhanced recovery pathways.

J Surg Oncol 2020 Jul 5. Epub 2020 Jul 5.

Department of Surgery, City of Hope National Medical Center, Duarte, California.

Background: Variations in care have been demonstrated both within and among institutions in many clinical settings. By standardizing perioperative practices, Enhanced Recovery After Surgery (ERAS) pathways reduce variation in perioperative care. We sought to characterize the variation in cytoreductive surgery (CRS)/heated intraperitoneal chemotherapy (HIPEC) perioperative practices among experienced US medical centers. Read More

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http://dx.doi.org/10.1002/jso.26099DOI Listing

An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group.

Eur Heart J 2020 Jul 6. Epub 2020 Jul 6.

Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London and Barts Heart Centre, London, UK.

This consensus document, a summary of the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI), appraises the importance of ischaemia with non-obstructive coronary arteries (INOCA). Angina pectoris affects approximately 112 million people globally. Up to 70% of patients undergoing invasive angiography do not have obstructive coronary artery disease, more common in women than in men, and a large proportion have INOCA as a cause of their symptoms. Read More

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http://dx.doi.org/10.1093/eurheartj/ehaa503DOI Listing

CLIF-C Organ Failure Score and Liver Volume Predict Prognosis in Steroid-Treated Severe Acute Autoimmune Hepatitis.

Hepatol Commun 2020 Jul 4;4(7):1019-1033. Epub 2020 May 4.

Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan.

Controversies and debates remain regarding the best management of severe acute-onset autoimmune hepatitis (SA-AIH) due to the lack of useful outcome or complication prediction systems. We conducted this clinical practice-based observational study to clarify whether Chronic Liver Failure Consortium Organ Failure scores (CLIF-C OFs) and the computed tomography-derived liver volume to standard liver volume (CTLV/SLV) ratio at admission to a tertiary transplant center can predict outcomes and complications due to infection. Thirty-four consecutive corticosteroid-treated patients with SA-AIH from 2007 to 2018 were included. Read More

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http://dx.doi.org/10.1002/hep4.1521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327221PMC

Endoscopic sedation practices of Greek gastroenterologists: a nationwide survey.

Ann Gastroenterol 2020 Jul-Aug;33(4):366-373. Epub 2020 May 15.

First Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece (Adonis A. Protopapas, Evangelos Stournaras, Georgios Neokosmidis, Dimitrios Stogiannou, Athanasios Filippidis, Andreas N. Protopapas).

Background: Sedation in gastrointestinal endoscopy is rapidly evolving worldwide. However, this has led to significant disagreements, especially regarding the use of propofol by non-anesthesiologists. The aim of this study was to document the practices of Greek gastroenterologists regarding sedation and compare them to previous surveys. Read More

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http://dx.doi.org/10.20524/aog.2020.0494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315718PMC

Nurses' decision-making about cancer patients' end-of-life skin care in Wales: an exploratory mixed-method vignette study protocol.

BMJ Open 2020 Jul 5;10(7):e034938. Epub 2020 Jul 5.

School of Healthcare Sciences, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom.

Introduction: Patients with cancer are at high risk of developing pressure ulcers at the end of life as a result of their underlying condition or cancer treatment. There are many guidelines which set out best practice with regard to end-of-life skin care. However, the complexity of palliative cancer care often means that it is challenging for nurses to make the appropriate person-centred decisions about end-of-life skin care. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034938DOI Listing

An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group.

EuroIntervention 2020 Jul 6. Epub 2020 Jul 6.

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University and Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.

This consensus document, a summary of the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI), appraises the importance of ischaemia with non-obstructive coronary arteries (INOCA). Angina pectoris affects approximately 112 million people globally. Up to 70% of patients undergoing invasive angiography do not have obstructive coronary artery disease, more common in women than in men, and a large proportion have INOCA as a cause of their symptoms. Read More

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http://dx.doi.org/10.4244/EIJY20M07_01DOI Listing

Treatment of Non-neurogenic Lower Urinary Tract Symptoms-A Review of Key Publications from 2018 Onward.

Eur Urol Focus 2020 Jul 2. Epub 2020 Jul 2.

Department of Urology, Hospital de S. João, Porto, Portugal; Faculty of Medicine, University of Porto, Porto, Portugal; i3S - IBMC - Instituto Investigação Inovação Saude, University of Porto, Porto, Portugal. Electronic address:

Context: A considerable number of studies addressing the management of lower urinary tract symptoms (LUTS) have been published since 2018.

Objective: To review the key studies involving pharmacological and neuromodulation treatment of LUTS published from 2018 onward.

Evidence Acquisition: We followed the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) statement. Read More

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http://dx.doi.org/10.1016/j.euf.2020.06.015DOI Listing

Canadian Cardiovascular Society Clinical Practice Update on the Assessment and Management of Syncope.

Can J Cardiol 2020 Jul 2. Epub 2020 Jul 2.

Department of Emergency Medicine, Queen's University, Kingston, Ontario, Canada.

Syncope is a symptom that occurs in multiple settings and has a variety of underlying causes, ranging from benign to life threatening. Determining the underlying diagnosis and prognosis can be challenging and often results in an unstructured approach to evaluation, which is ineffective and costly. In this first ever document, the Canadian Cardiovascular Society (CCS) provides a clinical practice update on the assessment and management of syncope. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.12.023DOI Listing

Academic electronic health records as a vehicle to augment the assessment of patient care skills in the didactic pharmacy curriculum.

Curr Pharm Teach Learn 2020 Sep 16;12(9):1056-1061. Epub 2020 Apr 16.

Ferris State University College of Pharmacy, 220 Ferris Drive, Big Rapids, MI 49307, United States. Electronic address:

Introduction: Standards 2016 state students must be "practice-ready" upon graduation and utilizing health information technology is one skill needed to ensure students are practice-ready. Incorporating academic electronic health records (EHRs) into the didactic pharmacy curriculum is one tool for preparing students to be practice-ready, but it is unclear if this technology is used to facilitate assessment of students' patient care skills.

Methods: A 35-question electronic survey was distributed to each school/college of pharmacy (S/COP) with questions focused on general use of EHRs and characterizing EHRs as a tool to assess students' patient care skills in the didactic curriculum. Read More

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http://dx.doi.org/10.1016/j.cptl.2020.04.004DOI Listing
September 2020

Translating Dysphagia Evidence into Practice While Avoiding Pitfalls: Assessing Bias Risk in Tracheostomy Literature.

Dysphagia 2020 Jul 4. Epub 2020 Jul 4.

School of Audiology and Speech Sciences, University of British Columbia, 2177 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.

Critically ill patients who require a tracheostomy often have dysphagia. Widespread practice guidelines have yet to be developed regarding the acute assessment and management of dysphagia in patients with tracheostomy. In order for clinicians to base their practice on the best available evidence, they must first assess the applicable literature and determine its quality. Read More

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http://dx.doi.org/10.1007/s00455-020-10151-wDOI Listing

Rhodococcus equi infection as inaugural manifestation of idiopathic CD4 lymphopenia: A rare entity and a therapeutic challenge.

Pulmonology 2020 Jul 1. Epub 2020 Jul 1.

Pulmonology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Rua Conceição Fernandes, 4434-502 Vila Nova de Gaia, Portugal.

We report a case of disseminated infection by Rhodococcus equi as the inaugural manifestation of idiopathic T-CD4 lymphopenia. We aim to demonstrate our diagnostic and therapeutic approach and focus on the major dilemmas arising from the lack of scientific evidence regarding best clinical practice of this infection in humans. Read More

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http://dx.doi.org/10.1016/j.pulmoe.2020.06.002DOI Listing