178,007 results match your criteria Best Practice & Research: Clinical Endocrinology & Metabolism[Journal]


Factors Associated with Caregiving Appraisal of Informal Caregivers: A Systematic Review.

J Clin Nurs 2020 Jul 3. Epub 2020 Jul 3.

Johns Hopkins University School of Nursing, 525 N. Wolfe Street, Baltimore, Maryland, United States.

Aims And Objectives: To identify factors associated with the caregiving appraisal of informal caregivers.

Background: Caregiving appraisal, the cognitive evaluation of the caregiving situation, is an essential factor in determining positive or negative caregiving outcomes. Identifying factors associated with appraisal is fundamental for designing effective health promotion strategies. Read More

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http://dx.doi.org/10.1111/jocn.15394DOI Listing

Predictors of worsening neuropathy and neuropathic pain after 12 years in people with HIV.

Ann Clin Transl Neurol 2020 Jul 3. Epub 2020 Jul 3.

Departments of Medicine and Psychiatry, University of California, San Diego, La Jolla, California.

Objective: Distal sensory polyneuropathy (DSP) and neuropathic pain are important clinical concerns in virally suppressed people with HIV. We determined how these conditions evolved, what factors influenced their evolution, and their clinical impact.

Methods: Ambulatory, community-dwelling HIV seropositive individuals were recruited at six research centers. Read More

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http://dx.doi.org/10.1002/acn3.51097DOI Listing

Classic and emergent indicators for the assessment of human iron status.

Crit Rev Food Sci Nutr 2020 Jul 3:1-14. Epub 2020 Jul 3.

Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.

Iron deficiency is the leading cause of anemia, a significant global public health problem. Different methods exist for assessing iron nutritional status, including laboratory tests that focus on storage, transportation, and iron functional compartment parameters. Classical markers such as bone marrow, serum iron, ferritin, hemoglobin, erythrocyte parameters, transferrin, transferrin receptors, and zinc protoporphyrin are discussed in this review. Read More

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http://dx.doi.org/10.1080/10408398.2020.1787326DOI Listing

Pain relief and recovery after breast cancer surgery: translating best evidence into practice.

Anaesthesia 2020 Jul 3. Epub 2020 Jul 3.

Department of Anesthesiology and Pain Medicine, University of Ottawa, ON, Canada.

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http://dx.doi.org/10.1111/anae.15033DOI Listing

Update on evidence in craniomaxillofacial surgery.

Curr Opin Otolaryngol Head Neck Surg 2020 Jun 28. Epub 2020 Jun 28.

Department of Otolaryngology at SUNY Upstate Medical University, Syracuse, New York, USA.

Purpose Of Review: Evidence-based medicine underpins clinical practice. Ideally, our clinical decision-making stems from systematic reviews of randomized controlled trials. However, in practice, this is not often the case, and we must instead rely on the best available evidence. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000642DOI Listing

Primary Care Perceptions and Practices on Discussion and Advice Regarding Sexual Practices.

South Med J 2020 Jul;113(7):356-359

From the Department of Family Medicine, Mayo Clinic, Jacksonville, Florida.

Objectives: The United States has experienced an increase in sexually transmitted infections (STIs) in the past decade, a trend that may be influenced by communication gaps between family physicians and patients. We sought to identify factors that hinder discussion about safe sexual practices and STIs, understand physicians' perceptions of their role in preventing STIs, and explore methods of initiating discussions on sexual health.

Methods: From April 30, 2016 to September 1, 2016, family physicians at our institution were given written surveys with 22 questions to answer and rank in order of their best practice. Read More

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http://dx.doi.org/10.14423/SMJ.0000000000001114DOI Listing

Recognizing, reporting and reducing the data curation debt of cohort studies.

Int J Epidemiol 2020 Jul 2. Epub 2020 Jul 2.

Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Good data curation is integral to cohort studies, but it is not always done to a level necessary to ensure the longevity of the data a study holds. In this opinion paper, we introduce the concept of data curation debt-the data curation equivalent to the software engineering principle of technical debt. Using the context of UK cohort studies, we define data curation debt-describing examples and their potential impact. Read More

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http://dx.doi.org/10.1093/ije/dyaa087DOI Listing

Achieving accurate estimates of fetal gestational age and personalised predictions of fetal growth based on data from an international prospective cohort study: a population-based machine learning study.

Lancet Digit Health 2020 Jul 23;2(7):e368-e375. Epub 2020 Jun 23.

Department of Physics, University of Wisconsin, Milwaukee, WI, USA.

Background: Preterm birth is a major global health challenge, the leading cause of death in children under 5 years of age, and a key measure of a population's general health and nutritional status. Current clinical methods of estimating fetal gestational age are often inaccurate. For example, between 20 and 30 weeks of gestation, the width of the 95% prediction interval around the actual gestational age is estimated to be 18-36 days, even when the best ultrasound estimates are used. Read More

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http://dx.doi.org/10.1016/S2589-7500(20)30131-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323599PMC

Endocrine Surgery during the COVID-19 Pandemic: Recommendations from the Turkish Association of Endocrine Surgery.

Sisli Etfal Hastan Tip Bul 2020 16;54(2):117-131. Epub 2020 Jun 16.

Department of General Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

The 2019 novel coronavirus disease (COVID-19) was initially seen in Wuhan, China, in December 2019. World Health Organization classified COVID-19 as a pandemic after its rapid spread worldwide in a few months. With the pandemic, all elective surgeries and non-emergency procedures have been postponed in our country, as in others. Read More

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http://dx.doi.org/10.14744/SEMB.2020.65902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326680PMC

EMQN best practice guidelines for molecular genetic testing and reporting of 21-hydroxylase deficiency.

Eur J Hum Genet 2020 Jul 2. Epub 2020 Jul 2.

Bioglobe GmbH, Grandweg 64, D-22529, Hamburg, Germany.

Molecular genetic testing for congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) is offered worldwide and is of importance for differential diagnosis, carrier detection and adequate genetic counseling, particularly for family planning. In 2008 the European Molecular Genetics Quality Network (EMQN) for the first time offered a European-wide external quality assessment scheme for CAH (due to 21-OH deficiency). The interest was great and over the last years at about 60 laboratories from Europe, USA and Australia regularly participated in that scheme. Read More

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http://dx.doi.org/10.1038/s41431-020-0653-5DOI Listing

Effects of physical exercise in sarcopenia. A systematic review.

Endocrinol Diabetes Nutr 2020 Jun 29. Epub 2020 Jun 29.

Unidad de Nutrición Clínica y Dietética, Departamento de Endocrinología y Nutrición, Complejo Asistencial Universitario de León, León, España.

From the third decade of life and due to multiple causes, muscle mass and strength are gradually lost, which affects the function of the musculoskeletal system. This combined loss of muscle mass and strength with aging is called sarcopenia, and is associated with greater morbidity and mortality in the elderly. Early treatment is therefore essential, and physical exercise is the therapeutic approach that has given the best results. Read More

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http://dx.doi.org/10.1016/j.endinu.2020.02.010DOI Listing

Why isn't there an evidence-based radiography? Reflections and a call to action.

Authors:
Z Munn

Radiography (Lond) 2020 Jun 29. Epub 2020 Jun 29.

JBI, The University of Adelaide, 55 King William Road, SA 5005, Australia. Electronic address:

In an ideal world all healthcare professionals (including radiographers and medical radiation professionals) would deliver care based on the best available evidence, ensuring best outcomes and optimal use of resources. Unfortunately, we know this is often not the case. This article calls for structural changes to enable the development of an evidence-based radiography. Read More

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http://dx.doi.org/10.1016/j.radi.2020.05.005DOI Listing

Best Practices in Patient Safety and Communication.

Emerg Med Clin North Am 2020 Aug 8;38(3):693-703. Epub 2020 Jun 8.

Massachusetts General Hospital, 55 Fruit Street, Bulfinch 290, Boston, MA 02114, USA.

Emergency medicine is a high-risk area of medical practice, with a high rate of preventable adverse events. This is multifactorial, hinging on the myriad system and processes issues that complicate emergency care. Strong teamwork and communication have been identified as critical components for safe care in emergency medicine. Read More

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http://dx.doi.org/10.1016/j.emc.2020.04.007DOI Listing

Change in opioid policies in New England emergency departments, 2014 vs 2018.

Drug Alcohol Depend 2020 Jun 10;213:108105. Epub 2020 Jun 10.

Department of Emergency Medicine, Massachusetts General Hospital, 125 Nashua St., Suite 920, Boston, MA 02114, United States. Electronic address:

Objective: The U.S. opioid epidemic persists, yet it is unclear if opioid-related emergency department (ED) policies have changed. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2020.108105DOI Listing

Dietary therapy for eosinophilic esophagitis: chances and limitations in the clinical practice.

Expert Rev Gastroenterol Hepatol 2020 Jul 2. Epub 2020 Jul 2.

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) , Spain.

Introduction: Eosinophilic esophagitis (EoE) is a non-IgE-mediated food allergy that currently represents the main cause of dysphagia and food impaction in children and young adults. Diet remains the only therapy targeting the cause of the disease. Relevant advances in recent years allow novel approaches to dietary therapy in EoE. Read More

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http://dx.doi.org/10.1080/17474124.2020.1791084DOI Listing

Exploring the use of curbside consultations for interprofessional collaboration and clinical decision-making.

J Interprof Care 2020 Jul 2:1-8. Epub 2020 Jul 2.

Nursing, University of Texas at Austin , Austin, TX, USA.

Nurse practitioners utilize curbside consultation, an interprofessional collaboration communication process in which one clinician seeks advice from another, in clinical decision-making practices. Nevertheless, this process is not well-understood. A qualitative design with individual open-ended interviews was used to explore the phenomenon of curbside consultation among nurse practitioners for clinical decision-making. Read More

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http://dx.doi.org/10.1080/13561820.2020.1768057DOI Listing

Decontamination Methods for Reuse of Filtering Facepiece Respirators.

JAMA Otolaryngol Head Neck Surg 2020 Jul 2. Epub 2020 Jul 2.

Department of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles.

Importance: The novel coronavirus disease 2019 (COVID-19) has proven to be highly infectious, putting health care professionals around the world at increased risk. Furthermore, there are widespread shortages of necessary personal protective equipment (PPE) for these individuals. Filtering facepiece respirators, such as the N95 respirator, intended for single use, can be reused in times of need. Read More

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http://dx.doi.org/10.1001/jamaoto.2020.1423DOI Listing

Therapy options after CDK4/6 inhibitors for HR+, HER2- postmenopausal metastatic/recurrent breast cancer in Japan: a role for mammalian target of rapamycin inhibitors?

Future Oncol 2020 Jul 2. Epub 2020 Jul 2.

Medical Oncology, Osaka International Cancer Institute, Osaka, Japan.

Despite advances in the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer, the disease is rarely curable. In this review, we focus on the use of cyclin-dependent kinase (CDK) 4/6 inhibitors, examining clinical experience and the mechanisms underlying the development of resistance, and evaluating treatment options after failure to respond to CDK4/6 inhibitors. Current basic research supports the use of mammalian target of rapamycin inhibitors after CDK4/6 inhibitor failure; however, more data are needed, particularly regarding treatment sequencing. Read More

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http://dx.doi.org/10.2217/fon-2020-0326DOI Listing

Mapping clinical outcomes to generic preference-based outcome measures: development and comparison of methods.

Health Technol Assess 2020 Jun;24(34):1-68

Centre for Health Economics, University of York, York, UK.

Background: Cost-effectiveness analysis using quality-adjusted life-years as the measure of health benefit is commonly used to aid decision-makers. Clinical studies often do not include preference-based measures that allow the calculation of quality-adjusted life-years, or the data are insufficient. 'Mapping' can bridge this evidence gap; it entails estimating the relationship between outcomes measured in clinical studies and the required preference-based measures using a different data set. Read More

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http://dx.doi.org/10.3310/hta24340DOI Listing

GAVeCeLT-WoCoVA Consensus on subcutaneously anchored securement devices for the securement of venous catheters: Current evidence and recommendations for future research.

J Vasc Access 2020 Jul 2:1129729820924568. Epub 2020 Jul 2.

University Hospital Agostino Gemelli, Rome, Italy.

Background: Subcutaneously anchored securement devices (or subcutaneous engineered securement devices) have been introduced recently into the clinical practice, but the number of published studies is still scarce. The Italian Group of Long-Term Central Venous Access Devices (GAVeCeLT)-in collaboration with WoCoVA (World Congress on Vascular Access)-has developed a Consensus about the effectiveness, safety, and cost-effectiveness of such devices.

Methods: After the definition of a panel of experts, a systematic collection and review of the literature on subcutaneously anchored securement devices was performed. Read More

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http://dx.doi.org/10.1177/1129729820924568DOI Listing

Facile synthesis of a novel AgPO/MIL-100(Fe) Z-scheme photocatalyst for enhancing tetracycline degradation under visible light.

Environ Sci Pollut Res Int 2020 Jul 1. Epub 2020 Jul 1.

School of Environmental & Safety Engineering, Changzhou University, Changzhou, 213164, China.

In this work, a novel visible light-driven heterostructure AgPO/MIL-100(Fe) composite photocatalyst was successfully synthesized via facile chemical deposition method at room temperature. Especially when the mass ratio of AgPO was 20% of MIL-100(Fe) (APM-2), it displayed the best photocatalytic performance, for which the degradation rate of tetracycline (TC) in conventional environment was 6.8 times higher than that of bare MIL-100(Fe). Read More

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http://dx.doi.org/10.1007/s11356-020-09903-wDOI Listing

Decompressive Surgery for Lumbar Spinal Stenosis: WFNS Spine Committee Recommendations.

World Neurosurg X 2020 Jul 10;7:100076. Epub 2020 Mar 10.

Neurosurgery Department, Humanitas Clinical and Research Hospital, Rozzano, Milan, Italy.

Objective: Lumbar spine stenosis is a common disease with a prevalence progressively increasing due to the aging of the population. Despite many papers having been published over the last decades, there still remain many doubts regarding its natural history and appropriate treatment. To overcome these problems and reach some globally accepted recommendations, the World Federation of Neurosurgical Society Spine Committee organized a consensus conference on this topic. Read More

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http://dx.doi.org/10.1016/j.wnsx.2020.100076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322794PMC

Lumbar Spinal Stenosis: Introduction to the World Federation of Neurosurgical Societies (WFNS) Spine Committee Recommendations.

World Neurosurg X 2020 Jul 10;7:100075. Epub 2020 Mar 10.

Neurosurgery Department, Humanitas Clinical and Research Hospital, Rozzano, Italy.

Introduction: Lumbar spinal stenosis (LSS) is a common degenerative disease that every spine surgeon will come across in daily practice. Despite this, the natural history and treatment have not been well established and standardized as yet, and there have been few guidelines published on this topic to date. The aim of the World Federation of Neurosurgical Society Spine Committee Consensus Conference is to define evidence-based and expert-based recommendations for the diagnosis and treatment of LSS, considering the different possibilities and facilities in countries worldwide. Read More

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http://dx.doi.org/10.1016/j.wnsx.2020.100075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322795PMC

The role of children in transmission of SARS-CoV-2: A rapid review.

J Glob Health 2020 Jun;10(1):011101

Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.

Background: Understanding the role of children in the transmission of SARS-CoV-2 is urgently required given its policy implications in relation to the reopening of schools and intergenerational contacts.

Methods: We conducted a rapid review of studies that investigated the role of children in the transmission of SARS-CoV-2. We synthesized evidence for four categories: 1) studies reporting documented cases of SARS-CoV-2 transmission by infected children; 2) studies presenting indirect evidence on the potential of SARS-CoV-2 transmission by (both symptomatic and asymptomatic) children; 3) studies reporting cluster outbreaks of COVID-19 in schools; 4) studies estimating the proportions of children infected by SARS-CoV-2, and reported results narratively. Read More

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http://dx.doi.org/10.7189/jogh.10.011101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323934PMC

Review of Variability in Rehabilitation Protocols after Lateral Ankle Ligament Surgery.

Kans J Med 2020 25;13:152-159. Epub 2020 Jun 25.

University of Kansas School of Medicine, Kansas City, KS.

Introduction: Ankle sprains are one of the most common athletic injuries. If a patient fails to improve through conservative management, surgery is an option to restore ankle stability. The purpose of this study was to analyze and assess the variability across different rehabilitation protocols for patients undergoing either lateral ankle ligament repair, reconstruction, and suture tape augmentation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324062PMC

Oral Spironolactone versus Conservative Treatment for Non-Resolving Central Serous Chorioretinopathy in Real-Life Practice.

Clin Ophthalmol 2020 24;14:1725-1734. Epub 2020 Jun 24.

KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Objective: To compare the efficacy of oral spironolactone treatment versus conservative treatment for patients with persistent central serous chorioretinopathy (CSC) in real-life practice.

Design: Retrospective comparative study.

Patients And Methods: Medical records and retinal images of 62 patients with non-resolving CSC were reviewed. Read More

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http://dx.doi.org/10.2147/OPTH.S260998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322117PMC

Value promotion as a goal of medicine.

J Med Ethics 2020 Jul 1. Epub 2020 Jul 1.

Department of English and Philosophy, US Military Academy, West Point, New York, United States.

In this paper, we argue that promoting patient values is a legitimate goal of medicine. Our view offers a justification for certain current practices, including birth control and living organ donation, that are widely accepted but do not fit neatly within the most common extant accounts of the goals of medicine (ie, those that focus on healing or best interests). Moreover, we argue that recognising value promotion as a goal of medicine will expand the scope of medical practice by including some procedures that are sometimes rejected as being outside the scope of acceptable medical practice, such as certain forms of physician-assisted death. Read More

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http://dx.doi.org/10.1136/medethics-2019-106047DOI Listing

Getting it right first time in radiology.

Clin Radiol 2020 Jun 28. Epub 2020 Jun 28.

Department of Clinical Imaging, Royal Cornwall Hospital, Truro TR1 3LJ, UK. Electronic address:

Getting it Right First Time (GIRFT) is a national programme designed to improve medical care in the National Health Service (NHS) in England by reducing unwarranted variation. By tackling variation in the way services are delivered across the NHS and by sharing best practice, GIRFT identifies changes that will help improve care and patient outcomes as well as delivering efficiencies. Read More

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http://dx.doi.org/10.1016/j.crad.2020.02.019DOI Listing

The law and problematic marketing by private umbilical cord blood banks.

BMC Med Ethics 2020 Jul 1;21(1):52. Epub 2020 Jul 1.

Health Law Institute, Faculty of Law, University of Alberta, Edmonton, Alberta, T6G 2H5, Canada.

Background: Private umbilical cord blood banking is a for-profit industry in which parents pay to store blood for potential future use. Governments have noted the tendency for private banks to oversell the potential for cord blood use, especially in relation to speculative cell therapies not yet supported by clinical evidence. We assessed the regulatory landscape governing private cord bank marketing in Canada. Read More

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http://dx.doi.org/10.1186/s12910-020-00494-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329494PMC

Sustainable workforce: South African Audiologists and Speech Therapists.

Hum Resour Health 2020 Jul 1;18(1):47. Epub 2020 Jul 1.

Division of Health Systems and Public Health, Department of Global Health, Stellenbosch University, Cape Town, 7505, South Africa.

Background: Audiologists and Speech Therapists play a vital role in addressing sustainable development goals by supporting people who are marginalised due to communication challenges. The global burden of disease and poor social living conditions impact negatively on the development of healthy communication, therefore requiring the services of Audiologist and Speech therapists. Against this background, we examined the demographic profile and the supply, need and shortfall of Audiologists and Speech Therapists in South Africa. Read More

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http://dx.doi.org/10.1186/s12960-020-00488-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329495PMC

Deliberative Processes by Health Technology Assessment Agencies: A Reflection on Legitimacy, Values and Patient and Public Involvement Comment on "Use of Evidence-informed Deliberative Processes by Health Technology Assessment Agencies Around the Globe".

Int J Health Policy Manag 2020 Apr 7. Epub 2020 Apr 7.

Research Center, University Hospital Center Ste Justine, Montreal, QC, Canada.

Legitimacy of deliberation processes leading to recommendations for public financing or clinical practice depends on the data considered, stakeholders involved and the process by which both of these are selected and organised. Oortwijn et al provides an interesting exploration of processes currently in place in health technology assessment (HTA) agencies. However, agencies are struggling with core issues central to their legitimacy that goes beyond the procedural exploration of Oortwijn et al, such as: how processes reflect the mission and values of the agencies? How they ensure that recommendations are fair and reasonable? Which role should be given to public and patient involvement? Do agencies have a positive impact on the healthcare system and the populations served? What are the drivers of their evolution? We concur with Culyer commentary on the need of learning from doing what works best and that a reflection is indeed needed to "enhance the fairness and legitimacy of HTA. Read More

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http://dx.doi.org/10.34172/ijhpm.2020.46DOI Listing

The Need for a National Accreditation Programme for Professionals Working in the Field of Animal Training and Behavioural Modification in New Zealand.

Animals (Basel) 2020 Jun 29;10(7). Epub 2020 Jun 29.

Department of Animal Welfare Science and Education, SPCA New Zealand, 0600 Auckland, New Zealand.

Companion animals are at risk of psychological (and physical) harm if outdated, incorrect or aversive methods of training or equipment are used during training and behavioural modification. Companion animal guardians often engage professional animal behaviour and training services, yet this industry is not regulated in New Zealand. A voluntary national accreditation and registration programme could act to protect the welfare of animals by robustly evaluating the experience, qualifications and training methods of industry professionals. Read More

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http://dx.doi.org/10.3390/ani10071111DOI Listing

Caesarean Section on Maternal Request: An Italian Comparative Study on Patients' Characteristics, Pregnancy Outcomes and Guidelines Overview.

Int J Environ Res Public Health 2020 Jun 29;17(13). Epub 2020 Jun 29.

Department of Maternal and Child Health and Urological Sciences, Sapienza, University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy.

In recent years, the rate of caesarean sections has risen all over the world. Accordingly, efforts are being made worldwide to understand this trend and to counteract it effectively. Several factors have been identified as contributing to the selection of caesarean section (CS), especially an obstetricians' beliefs, attitudes and clinical practices. Read More

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http://dx.doi.org/10.3390/ijerph17134665DOI Listing

Practice of breastfeeding in quilombola communities in the light of transcultural theory.

Rev Bras Enferm 2020 24;73(4):e20190191. Epub 2020 Jun 24.

Universidade Federal da Bahia. Salvador, Bahia, Brazil.

Objectives: to identify factors that interfere with the practice of exclusive breastfeeding in quilombola communities.

Methods: qualitative research based on the Transcultural Theory proposed by Madeleine Leininger, performed with quilombola mothers. For data collection, we used the semi-structured interview, conducted from June 2018 to January 2019. Read More

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http://dx.doi.org/10.1590/0034-7167-2019-0191DOI Listing

Guideline Recommendations for Oral Care After Acquired Brain Injury: Protocol for a Systematic Review.

JMIR Res Protoc 2020 Jul 1;9(7):e17249. Epub 2020 Jul 1.

School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada.

Background: Oral care is important to prevent buccal and systemic infections after an acquired brain injury (ABI). Despite recent advancements in the development of ABI clinical practice guidelines, recommendations for specific clinical processes and actions to attain adequate oral care often lack information.

Objective: This systematic review will (1) identify relevant ABI clinical practice guidelines and (2) appraise the oral care recommendations existing in the selected guidelines. Read More

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http://dx.doi.org/10.2196/17249DOI Listing

[Removal of BPA and EE2 from Water by Mn-Fe Embedded in Acicular Mullite].

Huan Jing Ke Xue 2020 Feb;41(2):763-772

College of Environment and Ecology, Chongqing University, Chongqing 400045, China.

Acicular mullite was modified by ferromanganese binary metal oxide (Mn-Fe) to improve the removal efficiency of endocrine disruptors by traditional water treatment practices, using the commercial ceramsite for comparison. The physicochemical properties of synthesized samples were characterized, and batch adsorption experiments were carried out to study the adsorption efficiency of bisphenol A (BPA) and 17-ethinylestradiol (EE2) on synthesized samples, investigating how solution chemistry and regeneration may affect the adsorption efficiency. Results show that the manganese oxide loaded on the acicular mullite was manganite with an average particle size of 450 nm. Read More

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http://dx.doi.org/10.13227/j.hjkx.201908009DOI Listing
February 2020

A meta-analytic evaluation of the diagnostic accuracy of the electrocardiographic Peguero-Lo Presti criterion for left ventricular hypertrophy.

J Clin Hypertens (Greenwich) 2020 Jul 1. Epub 2020 Jul 1.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon.

Although electrocardiography (ECG) is a cost-effective and convenient tool for routine screening of left ventricular hypertrophy (LVH), its performance has been shown to be poor. The Peguero-Lo Presti, a novel voltage criterion, was found to be potentially better than the most commonly used criteria. We conducted a systematic review and meta-analysis of its diagnostic accuracy compared to Cornell and Sokolow-Lyon voltage criteria. Read More

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http://dx.doi.org/10.1111/jch.13923DOI Listing

Targeting the medulloblastoma: a molecular-based approach.

Acta Biomed 2020 Jun 30;91(7-S):79-100. Epub 2020 Jun 30.

Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, Uni-versity of Pavia, Pavia, Italy.

Background: The lack of success of standard therapies for medulloblastoma has highlighted the need to plan a new therapeutic approach. The purpose of this article is to provide an overview of the novel treatment strategies based on the molecular characterization and risk categories of the medulloblastoma, also focusing on up-to-date relevant clinical trials and the challenges in translating tailored approaches into clinical practice.

Methods: An online search of the literature was carried out on the PubMed/MEDLINE and ClinicalTrials. Read More

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http://dx.doi.org/10.23750/abm.v91i7-S.9958DOI Listing

The neglected heart of medicine and education: Why medicine ought to be kinder.

Authors:
Alexander Hayes

Med Teach 2020 Jul 1:1-2. Epub 2020 Jul 1.

Faculty of Life Sciences and Medicine, King's College London, London, UK.

Medical school should teach and reward kindness more, nurturing our thoughts, and collating our kind acts. Through a reflection of my experiences with those working in health inclusion, I contend that our medical education should better prioritise a depth of understanding of another's feelings and needs. Recognising medical education as a powerful and formative experience for all of those involved, I emphasise the necessity of nurturing epistemic systems that allow kindness to flourish. Read More

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http://dx.doi.org/10.1080/0142159X.2020.1781073DOI Listing

Promoting clinical best practice in a user-centred design study of an upper limb rehabilitation robot.

Disabil Rehabil Assist Technol 2020 Jul 1:1-8. Epub 2020 Jul 1.

Department of Medicine, The University of Melbourne, Melbourne, Australia.

Despite their promise to increase therapy intensity in neurorehabilitation, robotic devices have not yet seen mainstream adoption. Whilst there are a number of contributing factors, it is obvious that the treating clinician should have a clear understanding of the objectives and limitations of robotic device use. This study sought to explore how devices can be developed to support a clinician in providing clinical best practice. Read More

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http://dx.doi.org/10.1080/17483107.2020.1785567DOI Listing

Physical and performance variables for talent identification in water polo.

J Sports Med Phys Fitness 2020 Jun 29. Epub 2020 Jun 29.

Italian Swimming Federation, Rome, Italy.

Background: The aim of this work was to compare anthropometric and general physical performance variables in young water polo athletes of three competitive levels, to identify the characteristic qualities and, therefore, the best variables for the identification of talent.

Methods: 57 young male water polo players between 12 and 14 years old were recruited for the study: 18 were recreational level (REC), 18 sub-elite level (SE) and 21 elite level (EL). To assess anthropometric characteristics the following measurements were used: body mass, height, waist circumference, hip circumference, chest circumference and arm span. Read More

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http://dx.doi.org/10.23736/S0022-4707.20.10712-6DOI Listing

Prostate cancer early diagnosis: circulating microRNA pairs potentially beyond single microRNAs upon 1231 serum samples.

Brief Bioinform 2020 Jul 1. Epub 2020 Jul 1.

King's College London.

The accuracy of prostate-specific antigen or clinical examination in prostate cancer (PCa) screening is in question, and circulating microRNAs (miRNAs) can be alternatives to PCa diagnosis. However, recent circulating miRNA biomarkers either are identified upon small sample sizes or cannot have robust diagnostic performance in every aspect of performance indicators. These may decrease applicability of potential biomarkers for the early detection of PCa. Read More

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http://dx.doi.org/10.1093/bib/bbaa111DOI Listing

Serotyping of and Its Relation with Capsule-Associated Virulence Genes, Antimicrobial Resistance Pattern, and Clinical Infections: A Descriptive Study in Medical Practice.

Infect Drug Resist 2020 24;13:1971-1980. Epub 2020 Jun 24.

Department of Infectious Disease, School of Medicine, Shahroud University of Medical Science, Shahroud, Iran.

Objective: , one of the clinical superbugs, causes diverse infections because of its variable capsular antigens. This study focused on and aimed to assess any correlation between capsular serotype, capsule-associated virulence genes, and evaluate its resistance to conventional antibiotics in order to gain insight into any regional differences.

Materials And Methods: A total of 61 collected from various clinical specimens were confirmed genotypically. Read More

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http://dx.doi.org/10.2147/IDR.S243984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321687PMC

Translating research evidence into clinical practice: a reminder of important clinical lessons in management of resistant hypertension through a case study in general practice.

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Department of General Practice, Curtin University Bentley Campus, Perth, Western Australia, Australia

A case of a 59-year-old man with resistant hypertension, despite 8 months of non-pharmacological and pharmacological management up to maximal doses of triple antihypertensive therapy. Review of the literature found a study that reported improved blood pressure control with bedtime dosing of antihypertensive treatment. Changing to bedtime dosage of antihypertensives resulted in significant improvement in blood pressure control to below target levels. Read More

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http://dx.doi.org/10.1136/bcr-2020-235007DOI Listing

Microbiome definition re-visited: old concepts and new challenges.

Microbiome 2020 Jun 30;8(1):103. Epub 2020 Jun 30.

Helmholtz Zentrum München, Oberschleissheim, Germany.

The field of microbiome research has evolved rapidly over the past few decades and has become a topic of great scientific and public interest. As a result of this rapid growth in interest covering different fields, we are lacking a clear commonly agreed definition of the term "microbiome." Moreover, a consensus on best practices in microbiome research is missing. Read More

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http://dx.doi.org/10.1186/s40168-020-00875-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329523PMC

A meta-review of literature reviews assessing the capacity of patients with severe mental disorders to make decisions about their healthcare.

BMC Psychiatry 2020 Jun 30;20(1):339. Epub 2020 Jun 30.

Department of Psychiatry, Parc Sanitari Sant Joan de Déu, Barcelona, Spain.

Background: Determining the mental capacity of psychiatric patients for making healthcare related decisions is crucial in clinical practice. This meta-review of review articles comprehensively examines the current evidence on the capacity of patients with a mental illness to make medical care decisions.

Methods: Systematic review of review articles following PRISMA recommendations. Read More

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http://dx.doi.org/10.1186/s12888-020-02756-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324958PMC

The Melanoma Genomics Managing Your Risk Study randomised controlled trial: statistical analysis plan.

Trials 2020 Jun 30;21(1):594. Epub 2020 Jun 30.

The University of Sydney, Melanoma Institute Australia, Sydney, NSW, Australia.

Background: The Melanoma Genomics Managing Your Risk Study is a randomised controlled trial that aims to evaluate the efficacy of providing information on personal genomic risk of melanoma in reducing ultraviolet radiation (UV) exposure, stratified by traditional risk group (low or high phenotypic risk) in the general population. The primary outcome is objectively measured total daily Standard Erythemal Doses at 12 months. Secondary outcomes include UV exposure at specific time periods, self-reported sun protection and skin-examination behaviours, psychosocial outcomes, and ethical considerations surrounding offering genomic testing at a population level. Read More

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http://dx.doi.org/10.1186/s13063-020-04351-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329549PMC

An Approach Based on Preference Learning for Identifying Experts Reasoning in Antibiotic Treatment.

Stud Health Technol Inform 2020 Jun;272:115-118

INSERM, Université de Paris, Sorbonne Université, Centre de Recherche des Cordeliers, Information Sciences to support Personalized Medicine, F-75006 Paris, France.

Clinical Practice Guidelines (CPGs) aim at improving the quality of health care by providing standardized best practices for diagnosis and treatment. However, physicians have difficulties to understand the (often implicit) rationale underlying expert recommendations. The aim of this paper is to propose an approach based on preference learning for building a model that is closest to the reasoning of experts to provide recommendations. Read More

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http://dx.doi.org/10.3233/SHTI200507DOI Listing