493,514 results match your criteria Best Practice & Research: Clinical Anaesthesiology[Journal]


Predictors of mucosal healing during induction therapy in patients with acute moderate-to-severe ulcerative colitis.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.

Background And Aim: The treat-to-target strategy has emerged in ulcerative colitis management. Mucosal healing is the best target, albeit not in induction therapy of acute diseases as clinical conditions vary over a short duration. To determine the targets during induction therapy for acute ulcerative colitis, we identified markers to predict mucosal healing at 3 and 12 months of initiating the induction therapy. Read More

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December 2018

Prospective Evaluation of Patients With X-Linked Retinoschisis During 18 Months.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5941-5956

Applied Genetic Technologies Corporation, Alachua, Florida, United States.

Purpose: Prospective evaluation of patients with X-linked retinoschisis (XLRS).

Methods: Fifty-six males XLRS patients, age ≥7 years, had retinal structure and function tests performed every 6 months during an 18-month period.

Results: Best corrected visual acuity (BCVA) was abnormal (mean ± SD logMAR 0. Read More

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December 2018
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Doing the best we can: the realities of measuring non-structural carbohydrates in trees.

Tree Physiol 2018 Dec 14. Epub 2018 Dec 14.

CSIRO Land and Water, Private Bag 12 Hobart, Australia.

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December 2018

Upregulation of the lactate transporter monocarboxylate transporter 1 at the blood-brain barrier in a rat model of attention-deficit/hyperactivity disorder suggests hyperactivity could be a form of self-treatment.

Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.

The Brain and Muscle Energy Group, Electron Microscopy Laboratory, Department of Oral Biology, University of Oslo, NO-0316 Oslo, Norway; Synaptic Neurochemistry and Amino Acid Transporters Labs, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences (IMB) and Healthy Brain Ageing Centre (SERTA), University of Oslo, NO-0317 Oslo, Norway; Center for Healthy Aging, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

The energy deficit hypothesis of attention-deficit/hyperactivity disorder (ADHD) suggests that low lactate production by brain astrocytes causes the symptoms of the disorder. Astrocytes are the main producers of lactate in the brain; however, skeletal muscles can produce the most lactate in the body. The lactate production by skeletal muscles increases with physical activity, as does the expression of the lactate transporter monocarboxylate transporter 1 (MCT1) at the blood-brain barrier (BBB). Read More

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December 2018

Fog collection as a strategy to sequester carbon in drylands.

Sci Total Environ 2018 Dec 5;657:391-400. Epub 2018 Dec 5.

Department of Agricultural, Food and Forestry Systems (GESAAF), Università degli Studi di Firenze, Florence, Italy. Electronic address:

Advection fog is the sole source of water for many near-the-sea arid areas worldwide such as the lomas, i.e. fog-dependant landscapes of the coastal zone of Peru and Northern Chile, where deforestation occurred since 16th century, leading to a progressive and severe desertification. Read More

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December 2018

Traditional attributes moo-ve over for some consumer segments: Relative ranking of fluid milk attributes.

Appetite 2018 Dec 11. Epub 2018 Dec 11.

Dept. of Agricultural Economics, Purdue University, 403 West State Street, West Lafayette, IN, 47907, USA.

Due to the decrease in fluid milk consumption as a beverage in the United States, the importance for dairy industry stakeholders to understand attribute preferences for consumer segments has increased. This paper uses a representative sample of U.S. Read More

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December 2018

Magnitude and correlates of postnatal care utilization among reproductive aged women in a rural district in eastern Ethiopia: A cross-sectional study.

Midwifery 2018 Dec 4;70:22-30. Epub 2018 Dec 4.

Research Centre for Generational Health and Ageing, Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW, Australia. Electronic address:

Background: Postnatal care is critical to detect and manage postpartum complications in the early stages as well as to prevent potentially life-threatening health conditions that lead to maternal death. However, postnatal care utilization is persistently low in Ethiopia. The aim of this study is to assess the magnitude and correlates of postnatal care utilization among reproductiveaged women in Kersa district, in eastern Ethiopia. Read More

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December 2018

Branching mechanisms shaping dendrite architecture.

Dev Biol 2018 Dec 11. Epub 2018 Dec 11.

The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, 4072, Australia. Electronic address:

A neuron's contribution to the information flow within a neural circuit is governed by the structure of its dendritic arbor. The geometry of the dendritic arbor directly determines synaptic density and the size of the receptive field, both of which influence the firing pattern of the neuron. Importantly, the position of individual dendritic branches determines the identity of the neuron's presynaptic partner and thus the nature of the incoming sensory information. Read More

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December 2018

Identification of putative non-host essential genes and novel drug targets against Acinetobacter baumannii by in silico comparative genome analysis.

Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Department of Biochemistry, Abdul Wali Khan University, Mardan, Pakistan.

Acinetobacter baumannii, the gram-negative bacteria emerged as an extremely critical pathogen causing nosocomial and different kinds of infections. A. baumannii exhibit resistivity towards various classes of antibiotics that shows that there is a dire need to search more drug targets by exploiting the full genome of the bacteria. Read More

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December 2018

Best practices for preparing radioactive specimens for EBSD analysis.

Micron 2018 Dec 7;118:1-8. Epub 2018 Dec 7.

Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, United States. Electronic address:

A wide variety of specimen preparation techniques are available for ensuring that specimen surface finish has the acceptable quality for electron backscatter diffraction (EBSD) analysis. These techniques include but are not limited to vibratory polishing, broad, and focused ion beam milling. They have been widely implemented in the field of nuclear materials science with a varying degree of success. Read More

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December 2018

Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease.

J Mol Cell Cardiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, United States. Electronic address:

Huntington's disease (HD) is a fatal hereditary neurodegenerative disorder, best known for its clinical triad of progressive motor impairment, cognitive deficits and psychiatric disturbances, is caused by CAG-repeat expansion in exon 1 of Huntingtin (HTT). However, in addition to the neurological disease, mutant HTT (mHTT), which is ubiquitously expressed in all tissues, impairs other organ systems. Not surprisingly, cardiovascular dysautonomia as well as the deterioration of circadian rhythms are among the earliest detectable pathophysiological changes in individuals with HD. Read More

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December 2018

Comparison of stool examination techniques to detect Opisthorchis viverrini in low intensity infection.

Acta Trop 2018 Dec 11. Epub 2018 Dec 11.

Department of Parasitology, Phramongkutklao College of Medicine, Bangkok, 10400, Thailand. Electronic address:

Opisthorchiasis, caused by Opisthorchis viverrini, remains the public health significance in Thailand, particularly in the northeastern region. Number of parasitological techniques is available for diagnosis. However, the detection the parasite's eggs in stool still referred as gold standard. Read More

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December 2018

Strategies in scheduling marine protected area establishment in a network system.

Ecol Appl 2018 Dec 14. Epub 2018 Dec 14.

ARC Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, Queensland, Australia.

Instantaneous implementation of systematic conservation plans at regional scales is rare. More typically, planned actions are applied incrementally over periods of years or decades. During protracted implementation, the character of the connected ecological system will change as a function of external anthropogenic pressures, local metapopulation processes, and environmental fluctuations. Read More

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December 2018

Predictable Electronic Tuning By Choice of Azine Substituent in Five Iron(II) Triazoles: Redox Properties and DFT Calculations.

Chem Asian J 2018 Dec 14. Epub 2018 Dec 14.

University of Otago, Chemistry, Union Place West, 9054, Dunedin , NEW ZEALAND.

Five new mononuclear iron(II) tris-ligand complexes, and four solvatomorphs, have been made from the azine-substituted 1,2,4-triazole ligands (Lazine): [FeII(Lpyridazine)3](BF4)2 (1), [FeII(Lpyrazine)3](BF4)2 (2), [FeII(Lpyridine)3](BF4)2 (3), [FeII(L2pyrimidine)3](BF4)2 (4), and [FeII(L4pyrimidine)3](BF4)2 (5). Single-crystal XRD and solid-state magnetometry reveal that all of them are low spin (LS) Fe(II), except for solvatomorph 5·4H2O. Evans method NMR studies in CD2Cl2, (CD3)2CO and CD3CN show that all are LS in these solvents, except 5 in CD2Cl2 (consistent with L4pyrimidine imposing the weakest field). Read More

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December 2018

A data-driven individual-based model of infectious disease in livestock operation: A validation study for paratuberculosis.

PLoS One 2018 14;13(12):e0203177. Epub 2018 Dec 14.

Department of Population Medicine and Diagnostic Sciences, Cornell University, College of Veterinary Medicine, Tower Road, Ithaca, New York, United States of America.

Chronic livestock diseases cause large financial loss and affect animal health and welfare. Controlling these diseases mostly requires precise information on both individual animal and population dynamics to inform the farmer's decisions, but even successful control programmes do by no means assure elimination. Mathematical models provide opportunities to test different control and elimination options rather than implementing them in real herds, but these models require robust parameter estimation and validation. Read More

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December 2018

Prediction of antibiotic resistance in Escherichia coli from large-scale pan-genome data.

PLoS Comput Biol 2018 Dec 14;14(12):e1006258. Epub 2018 Dec 14.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.

The emergence of microbial antibiotic resistance is a global health threat. In clinical settings, the key to controlling spread of resistant strains is accurate and rapid detection. As traditional culture-based methods are time consuming, genetic approaches have recently been developed for this task. Read More

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December 2018
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Society of Cardiovascular Anesthesiologists/European Association of Cardiothoracic Anaesthetists Practice Advisory for the Management of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery.

Anesth Analg 2019 Jan;128(1):33-42

Department of Perioperative Medicine, Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom.

Postoperative atrial fibrillation (poAF) is the most common adverse event after cardiac surgery and is associated with increased morbidity, mortality, and hospital and intensive care unit length of stay. Despite progressive improvements in overall cardiac surgical operative mortality and postoperative morbidity, the incidence of poAF has remained unchanged at 30%-50%. A number of evidence-based recommendations regarding the perioperative management of atrial fibrillation (AF) have been released from leading cardiovascular societies in recent years; however, it is unknown how closely these guidelines are being followed by medical practitioners. Read More

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January 2019

Nonexpanded Prefabricated Anterior Perforator of Transverse Cervical Artery Flap for Full Facial Reconstruction.

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Plastic and Aesthetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Hubei, China.

Background: Prefabricated flap is an important technique to reconstruct facial skin defects. There is no any procedure for full facial reconstruction, and we are the first one to accomplish it.

Methods: Instead of the traditional supraclavicular island flap, we choose nonexpanded flap pedicled by the anterior perforator of transverse cervical artery (ap-TCA) to repair the whole facial deformity. Read More

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December 2018
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Obstetric and Pediatric Provider Perspectives on Mandatory Reporting of Prenatal Substance Use.

J Addict Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Health Policy and Management, University of Pittsburgh Graduate School of Public Health (MJ); University of Pittsburgh School of Medicine (SM, CH); Magee-Womens Research Institute, University of Pittsburgh (JCC); Departments of Obstetrics, Gynecology and Reproductive Sciences and Internal Medicine, University of Pittsburgh, Pittsburgh, PA (JCC).

Objective: In many states, health care providers are legally required to report pregnant women who use substances, or infants affected by prenatal substance use, to child welfare authorities. The objective of this study was to characterize obstetric and pediatric providers' perceptions of and experiences with policies requiring mandatory reporting of prenatal substance use to child welfare authorities.

Methods: We conducted a qualitative interview study among 20 obstetric and pediatric providers to elicit participants' perspectives about and experience with current policy requiring mandatory reporting of prenatal substance use. Read More

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December 2018

Vitamin K: a nutrient which plays a little-known role in glucose metabolism.

Curr Opin Clin Nutr Metab Care 2018 Dec 12. Epub 2018 Dec 12.

Sorbonne Université, Diabetes Department, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris.

Purpose Of Review: Type 2 diabetes is one of the most important public health diseases. Type 2 diabetes pathophysiology involves multiple pathways, in which micronutrients could play a role. Among them, interest has grown concerning vitamin K. Read More

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December 2018

Statewide implementation of child trauma-focused practices using the community-based learning collaborative model.

Psychol Serv 2018 Dec 13. Epub 2018 Dec 13.

Institute of Behavioral Science.

A significant number of youth in the United States experience traumatic events that substantially increase the risk of physical and behavioral health problems across the life span. This public health concern warrants concerted efforts to promote trauma-informed, evidence-based practices that facilitate recovery. Although youth-focused trauma-specific treatments exist, determining effective ways to disseminate and implement these services-so that they are available, accessible, and sustainable-poses an ongoing challenge. Read More

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December 2018

Functional and Transcriptomic Characterization of a Dye-decolorizing Fungus from Rhizosphere.

Pol J Microbiol 2018 ;67(4):417-430

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences , Beijing , China.

We isolated three laccase-producing fungus strains from Taxus rhizosphere. Myrotheium verrucaria strain DJTU-sh7 had the highest laccase activity of 216.2 U/ml, which was increased to above 300 U/ml after optimization. Read More

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January 2018

How to Best Predict Fragility Fractures: An Update and Systematic Review.

Isr Med Assoc J 2018 Dec;20(12):773-779

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: Because fragility fractures have an enormous impact on the practice of medicine and global health systems, effective screening is imperative. Currently, dual-energy X-ray absorptiometry (DXA), which has limited ability to predict fractures, is being used. We evaluated the current literature for a method that may constitute a better screening method to predict fragility fractures. Read More

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December 2018

Exercises in anatomy: Ventricular septal defect.

Multimed Man Cardiothorac Surg 2018 Dec 6;2018. Epub 2018 Dec 6.

Institute of Genetic Medicine, Newcastle University, United Kingdom.

The phenotypic features of the heart with ventricular septal defects will be shown in this video tutorial. There is still no agreement as to whether it's best to categorize lesions on the basis of their geography or their borders. Both geography and borders are features that are of importance. Read More

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December 2018

Comparative study between Plate-Graff, Plate-Cage and peek cage in cervical spine fusion.

Acta Ortop Mex 2018 Jul-Aug;32(4):203-208

Spine Surgery Service. National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra. Mexico City. Mexico.

Objective: To compare results of Plate-Graff, Plate-Cage and PEEK cage in patients with cervical stenosis.

Material And Methods: Prospective, with before and after intervention and comparative study. From January 2005 to October 2011 we included 37 patients (male: 48. Read More

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December 2018

Abrupt Symptom Improvements in Antidepressant Clinical Trials: Transient Placebo Effects or Therapeutic Reality?

J Clin Psychiatry 2018 Dec 4;80(1). Epub 2018 Dec 4.

Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, USA.

Background: According to prevailing models and classical reports, abrupt responses to antidepressant medication are not true drug responses but rather transient placebo effects. By contrast, recent reports suggest that early sudden improvements have a lasting effect and appear in most patients receiving medication. Clinical guidelines influenced by these contradictory findings are mixed and confusing. Read More

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December 2018

Randomized phase II/III confirmatory treatment selection design with a change of survival end points: Statistical design of Radiation Therapy Oncology Group 1216.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: To confirm the treatment effects of concurrent cetuximab plus docetaxel observed in Radiation Therapy Oncology Group (RTOG) 0234 and single out the effect of cetuximab, we designed RTOG 1216, a randomized phase II/III study, which uses an intermediate end point to select the best regimen for definitive testing of survival benefit.

Methods: In phase II, the best regimen should demonstrate statistically significant efficacy against the control with predefined advantage over the competing arm regarding disease-free survival (DFS). We evaluate operating characteristics of the randomized II/III group sequential design through simulations and numerical integrations under the null and various alternative hypotheses. Read More

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December 2018

Underaddressed animal-welfare issues in conservation.

Conserv Biol 2018 Dec 14. Epub 2018 Dec 14.

College of Veterinary Medicine, School of Veter…cut the number of references to the best 3inary and Life Sciences, Murdoch University, 90 South St, Murdoch, WA 6160, Australia.

Much progress has been made improving animal welfare in conservation over the past two decades. However, several glaring knowledge gaps remain where animal welfare concerns exist but animal welfare studies have not been performed in politically sensitive contexts. We use examples from Australia to identify four such issues lacking meaningful analysis; the absence of animal welfare oversight for operations designated as "management" (as opposed to research), the lack of consideration for the animal welfare impacts of biological agents that are used to control invasive animals, the paucity of studies to examine the welfare of animals that are hunted recreationally, and the scarcity of studies to examine the animal welfare impacts associated with Indigenous wildlife use. Read More

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December 2018

Electronic patient identification for sample labeling reduces wrong blood in tube errors.

Transfusion 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology and the Institute for Transfusion Medicine, University of Pittsburgh, Pittsburgh, PA.

Background: Wrong blood in tube (WBIT) errors are a preventable cause of ABO-mismatched RBC transfusions. Electronic patient identification systems (e.g. Read More

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December 2018

Bayesian latent class analysis of ELISA and RT-rPCR diagnostic accuracy for subclinical Renibacterium salmoninarum infection in Atlantic salmon (Salmo salar) broodstock.

J Fish Dis 2018 Dec 14. Epub 2018 Dec 14.

Marine Harvest Canada, Campbell River, British Columbia, Canada.

Renibacterium salmoninarum infection causes bacterial kidney disease (BKD) in salmonid freshwater and saltwater life stages, with potentially severe financial loss for the aquaculture industry. Preventing vertical transmission, from infected broodstock to eggs, is key to disease management. As there is no perfect reference standard for detecting R. Read More

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December 2018

FDG-PET/CT for diagnosis and follow-up of necrotizing (malignant) external otitis.

Laryngoscope 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology-Head and Neck Surgery, Petach Tikva, Israel.

Objective: Imaging is important for the diagnosis and follow-up of necrotizing external otitis (NEO). The best imaging modality is controversy. To suggest 2-deoxy-2-[fluorine-18] fluoro-D-glucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) as an alternative to technetium-99m and gallium-67 scans for diagnosis and assessment of response to treatment for patients with NEO. Read More

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December 2018

Optic Disc Coloboma in children - prevalence, clinical characteristics and associated morbidity.

Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Purpose: The aim of the study was to report prevalence, ocular outcome, neurological characteristics, cognitive and behavioural problems in children with optic disc coloboma (ODC).

Methods: This was a population-based, cross-sectional study of 31 children between 2 and 18 years of age diagnosed with ODC. The children were part of a larger cohort of 184 children with congenital optic disc malformations. Read More

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December 2018
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Retinal metabolic and structural alterations in response to aflibercept treatment in neovascular age-related macular degeneration.

Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology, Odense University Hospital, Odense, Denmark.

Purpose: Non-invasive retinal markers of disease activity could pave the way for individualized treatment in neovascular age-related macular degeneration (nAMD). We aimed to evaluate if retinal vascular oxygen saturation and calibres could predict the initial treatment response after a loading phase of intravitreal aflibercept in nAMD.

Method: A total of 149 eyes were included (nAMD, n = 76; dry AMD, n = 30; normal eyes n = 43). Read More

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December 2018

A controlled study of the Collaborative Care Skills Workshops versus Psycho-educational Workshops among Spanish caregivers of relatives with an eating disorder.

Eur Eat Disord Rev 2018 Dec 13. Epub 2018 Dec 13.

Usera Mental Health Center, 12 de Octubre University Hospital, Madrid, Spain.

The aim of this study was to test the hypothesis that a negative reaction to the illness would be reduced through the "Collaborative Care Skills Workshops" programme among Spanish caregivers of relatives with an eating disorder. Caregivers were randomly allocated to either the skill-based workshops (n = 32) or psycho-educational workshops (n = 31), and assessments were carried out over time (T vs. T vs. Read More

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December 2018

Mental health carers' experiences of an Australian Carer Peer Support program: Tailoring supports to carers' needs.

Health Soc Care Community 2018 Dec 13. Epub 2018 Dec 13.

Psychosocial Research Centre, Department of Psychiatry, University of Melbourne, Coburg, Victoria, Australia.

Carer Peer Support Workers (CPSWs) are people who have lived experience as carers/family members of persons with a mental illness, and are employed to provide support to other carers/family members. This qualitative study aimed to explore carers' experiences within a community-based CPSW pilot program in an Australian mental health service. Semi-structured phone interviews were conducted with 20 carer participants in 2015, 5-10 months following their last contact with the service. Read More

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December 2018

Longitudinal change in the cerebroplacental ratio and the risk of stillbirth.

Ultrasound Obstet Gynecol 2018 Dec 13. Epub 2018 Dec 13.

Fetal Medicine Unit, St George's Hospital, St George's University of London, UK Cranmer Terrace, London, SW17 0RE.

Objectives: To investigate whether the longitudinal Doppler changes in small-for-gestational age (SGA) fetuses improves the prediction of those at risk of intrauterine fetal death (IUFD).

Methods: A longitudinal study using two cohorts of singleton pregnancies (SGA and appropriate for gestational age [AGA]). The inclusion criteria for the SGA cohort were singleton pregnancies at 20 weeks' gestation or beyond and diagnosed with SGA. Read More

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December 2018

Validation of diagnostic methods for traumatic sensory neuropathy and neuropathic pain.

Muscle Nerve 2018 Dec 14. Epub 2018 Dec 14.

Departments of Clinical Neurophysiology, University of Turku and Turku University Hospital, Postal Box 52, 20521, Turku, Finland.

Introduction: We evaluated diagnostic value of sensory tests during recovery from iatrogenic sensory neuropathy using intraoperatively verified nerve injury with subjective symptoms as gold standard.

Methods: Inferior alveolar nerves were monitored neurophysiologically throughout mandibular osteotomy in 19 patients. Sensory disturbance was registered and sensation tested using clinical and quantitative sensory (QST) and neurophysiologic tests postoperatively at 1, 3, 6, 12 months. Read More

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December 2018

Positive Cooperative Effect in Ion-Pair Recognition by a Tris-urea Hemicryptophane Cage.

Chemistry 2018 Dec 13. Epub 2018 Dec 13.

FRANCE.

The synthesis of a hemicryptophane cage combining a CTV unit with a C3 symmetrical moiety bearing three urea functions is reported. This host was found to bind anions with higher binding constants than other previously reported hemicryptophanes. Due to its heteroditopic character this cage proved to be an efficient ion-pair receptor. Read More

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December 2018

Detection of Epstein-Barr virus (EBV)-encoded microRNAs in plasma of patients with nasopharyngeal carcinoma.

Head Neck 2018 Dec 13. Epub 2018 Dec 13.

Division of Head and Neck, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China.

Background: Nasopharyngeal carcinoma (NPC) latently infected by Epstein-Barr virus (EBV) expresses 40 EBV BART microRNAs (miRNAs). Difference in diagnostic efficacy of these miRNAs on NPC detection was observed. Here, we performed a comprehensive evaluation on the efficacy of these miRNAs. Read More

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December 2018

Probing Energy Migration through Precise Control of Interfacial Energy Transfer in Nanostructure.

Adv Mater 2018 Dec 13:e1806308. Epub 2018 Dec 13.

State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, and Institute of Optical Communication Materials, South China University of Technology, Guangzhou, 510641, China.

A novel mechanistic strategy for probing the energy migration through constructing the interfacial energy transfer (IET) in a core-shell-shell nanostructure is reported. In this design, the trilayer nanostructure is composed of a sensitizing core, a migratory interlayer, and a detective shell layer that interact with each other only by IET and the latter two shell layers are nonresponsive to the incident irradiation. This model is well applied in investigating the energy migration over the Tb, Gd, and Yb sublattices, and the results show that the Gd sublattice holds the best energy migratory performance. Read More

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December 2018

Trends in Female Leadership at High-Profile Otolaryngology Journals, 1997-2017.

Laryngoscope 2018 Dec 13. Epub 2018 Dec 13.

Department of Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington.

Objectives: To determine the proportion and relative advancement of women in leadership positions at high-impact otolaryngology journals.

Methods: Nine clinical otolaryngology journals were selected based on high impact factor and subspecialty representation (journal impact factor, 2016: 1.16-2. Read More

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December 2018

Computational investigation into the fluorescence of luciferin analogues.

J Comput Chem 2019 Jan;40(2):527-531

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts.

Luciferin analogues that display bioluminescence at specific wavelengths can broaden the scope of imaging and biological assays, but the need to design and synthesize many new analogues can be time-consuming. Employing a collection of previously synthesized and characterized aminoluciferin analogues, we demonstrate that computational TD-DFT methods can accurately reproduce and further explain the experimentally measured fluorescence wavelengths. The best computational approach yields a correlation with experiment of r = 0. Read More

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January 2019

Association Between Muscle Strength and Modeling Estimates of Muscle Tissue Heterogeneity in Young and Old Adults.

J Ultrasound Med 2018 Dec 12. Epub 2018 Dec 12.

Research Service, Washington, DC, USA.

Objectives: Assessing aging muscle through estimates of muscle heterogeneity may overcome some of the limitations of grayscale analyses. The objectives of this study included determining statistical model parameters that characterize muscle echogenicity and are associated with strength in younger and older participants.

Methods: Thirty-three community-dwelling participants were assigned to younger and older groups. Read More

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December 2018

Predictive probability of success using surrogate endpoints.

Stat Med 2018 Dec 12. Epub 2018 Dec 12.

Dipartimento di Scienze Matematiche (DISMA) Giuseppe Luigi Lagrange, Politecnico di Torino, Turin, Italy.

The predictive probability of success of a future clinical trial is a key quantitative tool for decision-making in drug development. It is derived from prior knowledge and available evidence, and the latter typically comes from the accumulated data on the clinical endpoint of interest in previous clinical trials. However, a surrogate endpoint could be used as primary endpoint in early development and, usually, no or limited data are collected on the clinical endpoint of interest. Read More

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December 2018

Abnormal Morphological and Functional Nature of Bone Marrow Stromal Cells Provides Preferential Support for Survival of Acute Myeloid Leukemia Cells.

Int J Cancer 2018 Dec 13. Epub 2018 Dec 13.

Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel.

Hematopoietic progenitors, residing in the bone marrow (BM) niche, are supported by mesenchymal stromal cells (MSCs). Cytogenetic and molecular aberrations in these progenitors lead to acute myeloid leukemia (AML). The BM-MSC role in leukemogenesis is not fully elucidated. Read More

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December 2018

The effect of a teamwork intervention on staff perception of teamwork and patient care on a medical surgical unit.

Nurs Forum 2018 Dec 12. Epub 2018 Dec 12.

School of Nursing, Western Kentucky University, Bowling Green, Kentucky.

As a result of the ever-changing health care environment and patient complexity, it is difficult for nursing teams to provide safe quality care and complete all tasks, also known as missed nursing care. Missed nursing care is a global health care issue and defined as any aspect of care missed in part, in whole, or delayed. Teamwork has been found to not only positively impact the performance of a team, but also patient outcomes. Read More

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December 2018

Contemporary Management of Direct Oral Anticoagulants During Cardioversion and Ablation for Nonvalvular Atrial Fibrillation.

Pharmacotherapy 2018 Dec 12. Epub 2018 Dec 12.

Professor of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee.

Introduction: As overall prevalence of atrial fibrillation (AF) continues to rise, the number of patients who undergo ablation, or electrical/chemical cardioversion, to restore normal sinus rhythm continues to increase as well. As direct oral anticoagulants (DOACs) have continued to be incorporated into clinical practice for long-term anticoagulation for AF, experience with how best to manage use of DOACs during electrophysiologic procedures is evolving.

Objective: This review is intended to provide health care providers with a summary of current evidence regarding the use of DOACs during cardioversion and catheter ablation and provide key considerations for their use during such electrophysiologic procedures. Read More

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December 2018