176,812 results match your criteria Best Practice & Research In Clinical Gastroenterology[Journal]


COVID-19 and the eye: how much do we really know? A best evidence review.

Arq Bras Oftalmol 2020 Jun 29;83(3):250-261. Epub 2020 May 29.

Centro Mexicano de Salud Visual Preventiva, Mexico City, Mexico.

To identify and classify available information regarding COVID-19 and eye care according to the level of evidence, within four main topics of interest: evidence of the virus in tears and the ocular surface, infection via the conjunctival route, ocular manifestations, and best practice recommendations. A structured review was conducted in PubMed, ScienceDirect, LILACS, SciELO, the Cochrane Library and Google Scholar on COVID-19 and ophthalmology. The Oxford Centre for Evidence Based Medicine 2011 Levels of Evidence worksheet was used for quality assessments. Read More

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http://dx.doi.org/10.5935/0004-2749.20200067DOI Listing

Assigning mentors for new HSC faculty hires: A preliminary policy evaluation.

Chron Mentor Coach 2019 Oct;3(Spec Iss 12):427-432

University of New Mexico School of Medicine; University of New Mexico College of Nursing.

Effective practices for selecting mentors for new faculty at academic health centers (AHC) are currently unknown. The University of New Mexico's School of Medicine assigns a mentor to all new faculty at the time of hire. The effectiveness of this policy measure has not been previously evaluated. Read More

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October 2019

Ethical issues in poultry production - Datasets from a German consumer survey.

Data Brief 2020 Aug 20;31:105748. Epub 2020 May 20.

Leibniz Centre for Agricultural Landscape Research (ZALF), Eberswalder Strasse 84, 15374 Muencheberg, Germany.

The killing of day-old chicks is controversially discussed in poultry keeping, science, politics, and society. The present survey data contributes to understand consumers´ attitudes towards ethical issues in chicken production, especially the killing practice and dual purpose chickens as alternative to avoid such killing. Information on the various topics is provided: Consumer purchase pattern of eggs and chicken meat, perception of animal welfare and protection issues, knowledge and perception of killing day-old chicks, attitudes towards dual purpose chickens as an alternative to killing day-old chicks, and socio-demographic data. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256461PMC

Microsurgical reconstruction affects the outcome in a translational mouse model for Achilles tendon healing.

J Orthop Translat 2020 Sep 11;24:1-11. Epub 2020 May 11.

Department of Regenerative Musculoskeletal Medicine, Institute of Musculoskeletal Medicine, Westfaelische Wilhelms University Muenster, Muenster, Germany.

Background: Animal models are one of the first steps in translation of basic science findings to clinical practice. For tendon healing research, transgenic mouse models are important to advance therapeutic strategies. However, the small size of the structures complicates surgical approaches, histological assessment, and biomechanical testing. Read More

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http://dx.doi.org/10.1016/j.jot.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260609PMC
September 2020

A digital decision support system (selfBACK) for improved self-management of low back pain: a pilot study with 6-week follow-up.

Pilot Feasibility Stud 2020 23;6:72. Epub 2020 May 23.

Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Background: Very few of the publicly available apps directed towards self-management of low back pain (LBP) have been rigorously tested and their theoretical underpinnings seldom described. The selfBACK app was developed in collaboration with end-users and clinicians and its content is supported by best evidence on self-management of LBP. The objectives of this pilot study were to investigate the basis for recruitment and screening procedures for the subsequent randomized controlled trial (RCT), to test the inclusion process in relation to questionnaires and app installation, and finally to investigate the change in primary outcome over time. Read More

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http://dx.doi.org/10.1186/s40814-020-00604-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245029PMC

Baseline staging imaging for distant metastasis in women with stages I, II, and III breast cancer.

Curr Oncol 2020 Apr 1;27(2):e123-e145. Epub 2020 May 1.

Division of Medical Oncology, Sunnybrook Health Sciences Centre, Toronto, ON.

Background: In Ontario, there is no clearly defined standard of care for staging for distant metastasis in women with newly diagnosed and biopsy-confirmed breast cancer whose clinical presentation is suggestive of early-stage disease. This guideline addresses baseline imaging investigations for women with newly diagnosed primary breast cancer who are otherwise asymptomatic for distant metastasis.

Methods: The medline and embase databases were systematically searched for evidence from January 2000 to April 2019, and the best available evidence was used to draft recommendations relevant to the use of baseline imaging investigation in women with newly diagnosed primary breast cancer who are otherwise asymptomatic. Read More

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http://dx.doi.org/10.3747/co.27.6147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253735PMC

Incorporating preauthorization into antimicrobial stewardship pharmacist workflow reduces and gastrointestinal panel testing.

Infect Control Hosp Epidemiol 2020 Jun 3:1-6. Epub 2020 Jun 3.

Department of Pharmacy, University of Michigan, Ann Arbor, Michigan.

Objective: To evaluate whether incorporating mandatory prior authorization for Clostridioides difficile testing into antimicrobial stewardship pharmacist workflow could reduce testing in patients with alternative etiologies for diarrhea.

Design: Single center, quasi-experimental before-and-after study.

Setting: Tertiary-care, academic medical center in Ann Arbor, Michigan. Read More

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http://dx.doi.org/10.1017/ice.2020.236DOI Listing

Augmented and Virtual Reality in Anatomical Education - A Systematic Review.

Adv Exp Med Biol 2020 ;1235:89-101

Anatomy Facility, School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Learning anatomy traditionally has depended on traditional techniques like human cadaveric dissection and the use of textbooks. As technology advances at an ever-rapid speed, there are revolutionary ways to learn anatomy. A number of technologies, techniques and methodologies are utilised in anatomical education, but ones specifically receiving a lot of interest and traction is that of augmented reality and virtual reality. Read More

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http://dx.doi.org/10.1007/978-3-030-37639-0_5DOI Listing
January 2020

Ultrasound-Guided Regional Anaesthesia: Visualising the Nerve and Needle.

Adv Exp Med Biol 2020 ;1235:19-34

NHS Tayside, Dundee, Scotland, UK.

Regional anaesthesia involves targeting specific peripheral nerves with local anaesthetic. It facilitates the delivery of anaesthesia and analgesia to an increasingly complex, elderly and co-morbid patient population. Regional anaesthesia practice has been transformed by the use of ultrasound, which confers advantages such as accuracy of needle placement, visualisation of local anaesthetic spread, avoidance of intraneural injection and the ability to accommodate for anatomical variation. Read More

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http://dx.doi.org/10.1007/978-3-030-37639-0_2DOI Listing
January 2020

Can the provision of sexual healthcare for oncology patients be improved? A literature review of educational interventions for healthcare professionals.

J Cancer Surviv 2020 Jun 1. Epub 2020 Jun 1.

Department of Urology, Leiden University Medical Centre, PO-box 9600, 2300 WB, Leiden, The Netherlands.

Purpose: Sexual health is an important quality-of-life concern for cancer patients and survivors, but a difficult discussion topic for patients and healthcare professionals. The most important barriers causing healthcare professionals to avoid the topic are lack of education and lack of knowledge. How effective education about sexual health is for oncology healthcare professionals is not clear. Read More

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http://dx.doi.org/10.1007/s11764-020-00898-4DOI Listing

Clinical trials of acute mechanical circulatory support in cardiogenic shock and high-risk percutaneous coronary intervention.

Curr Opin Cardiol 2020 Jun 1. Epub 2020 Jun 1.

The Cardiovascular Center for Research and Innovation, Tufts Medical Center, Boston, Massachusetts, USA.

Purpose Of Review: Acute mechanical circulatory support devices have become widely used in cardiogenic shock and high-risk percutaneous coronary intervention (PCI) but there remains significant controversy over the evidence supporting their use and the specific roles of various devices. In this review, we summarize major recent studies and identify key areas of future investigation.

Recent Findings: In cardiogenic shock, uncontrolled single arm studies emphasizing early mechanical circulatory support (MCS) have showed promising results, but randomized trials have either been stopped prematurely or enrolled patients with advanced shock unlikely to benefit from MCS. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000751DOI Listing

New Graduate Orientation Evaluation: Are There Any Best Practices Out There?: A Scoping Review.

J Nurses Prof Dev 2020 Jun 1. Epub 2020 Jun 1.

Jennifer Laflamme, MSN, RN-BC, CHFN, is Research Assistant (Pre-Diem), Center for Nursing Research and Quality Outcomes, Maine Medical Center, Portland. Kristiina Hyrkas, PhD, LicNSc, MNSc, RN, is Director, Center for Nursing Research and Quality Outcomes, Maine Medical Center, and Adjunct Professor, University of Southern Maine, Portland.

Efficient, cost-effective, and safe orientations with clear expectations are necessary for new graduates in their transition from student to practicing nurse. In the current nursing shortage, healthcare needs to invest more in retaining new graduates. Orientation can be a factor in decisions to leave. Read More

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http://dx.doi.org/10.1097/NND.0000000000000642DOI Listing

Helping Unlock Better Care (HUB|C) using quality improvement science in community pharmacies - An implementation method.

Res Social Adm Pharm 2020 May 16. Epub 2020 May 16.

University of Waterloo School of Pharmacy, 10A Victoria St S, Kitchener, ON, N2G 1C5, Canada; OPEN, Ontario Pharmacy Evidence Network, Canada. Electronic address:

Introduction: Community pharmacists' optimal scope of practice extends far beyond traditional dispensing or compounding, and health promotion or chronic disease management services based in the pharmacy can generate significant social and economic value. But, with many competing demands and performance expectations from patients, payers, and policymakers, many pharmacies face challenges when introducing, maintaining, optimizing, or integrating their service offerings. Quality Improvement (QI) science may provide a practical change management framework for pharmacy professionals to lead their teams in embracing optimal scope and in making pharmacy-based services more feasible and attractive for all parties. Read More

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http://dx.doi.org/10.1016/j.sapharm.2020.05.006DOI Listing

Duration of antibiotic therapy in critically ill patients: a randomized controlled trial of a clinical and C-reactive protein-based protocol versus an evidence-based best practice strategy without biomarkers.

Crit Care 2020 Jun 1;24(1):281. Epub 2020 Jun 1.

Graduate Program in Health Sciences: Infectious Diseases and Tropical Medicine, Department of Internal Medicine, School of Medicine and Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Background: The rational use of antibiotics is one of the main strategies to limit the development of bacterial resistance. We therefore sought to evaluate the effectiveness of a C-reactive protein-based protocol in reducing antibiotic treatment time in critically ill patients.

Methods: A randomized, open-label, controlled clinical trial conducted in two intensive care units of a university hospital in Brazil. Read More

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http://dx.doi.org/10.1186/s13054-020-02946-yDOI Listing

After initial invigoration by heading, young pear trees show reduction in axis vigour and increased propensity to flower.

Funct Plant Biol 2012 Feb;40(1):34-43

The New Zealand Institute for Plant and Food Research Limited, Hawke's Bay Research Centre, Private Bag 1401, Havelock North, New Zealand.

Fast establishment of the canopy in young trees, followed by reduced vegetative vigour and precocity are desirable traits in fruit production. Severe heading (cutting back the primary axis of the tree after the first year of growth) to induce branching is a nursery practice to increase early fruit yield. Our aim was to provide a systematic study of the responses of young pear trees to severe heading. Read More

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http://dx.doi.org/10.1071/FP12164DOI Listing
February 2012

The development an artificial intelligence algorithm for early sepsis diagnosis in the intensive care unit.

Int J Med Inform 2020 May 21;141:104176. Epub 2020 May 21.

Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Background: Severe sepsis and septic shock are still the leading causes of death in Intensive Care Units (ICUs), and timely diagnosis is crucial for treatment outcomes. The progression of electronic medical records (EMR) offers the possibility of storing a large quantity of clinical data that can facilitate the development of artificial intelligence (AI) in medicine. However, several difficulties, such as poor structure and heterogenicity of the raw EMR data, are encountered when introducing AI with ICU data. Read More

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http://dx.doi.org/10.1016/j.ijmedinf.2020.104176DOI Listing

Knowledge vs. know-how? Dissecting the foundations of stone knapping skill.

J Hum Evol 2020 May 30;145:102807. Epub 2020 May 30.

Department of Anthropology, Emory University, Atlanta, GA, USA.

Stone tools provide some of the best remaining evidence of behavioral change over long periods, but their cognitive and evolutionary implications remain poorly understood. Here, we contribute to a growing body of experimental research on the cognitive and perceptual-motor foundations of stone toolmaking skills by using a flake prediction paradigm to assess the relative importance of technological understanding vs. accurate action execution in Late Acheulean-style handaxe production. Read More

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http://dx.doi.org/10.1016/j.jhevol.2020.102807DOI Listing

Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT.

Health Technol Assess 2020 May;24(25):1-150

School of Health Sciences, Bangor University, Bangor, UK.

Background: Most people who are dying want to be cared for at home, but only half of them achieve this. The likelihood of a home death often depends on the availability of able and willing lay carers. When people who are dying are unable to take oral medication, injectable medication is used. Read More

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http://dx.doi.org/10.3310/hta24250DOI Listing

Role of Policy in Best-Practice Dissemination: Informal Professional Advice Networks in Canadian Long-Term Care.

Can J Aging 2020 Jun 2:1-11. Epub 2020 Jun 2.

Faculty of Nursing, University of Alberta.

This article examines provincial policy influence on long-term care (LTC) professionals' advice-seeking networks in Canada's Maritime provinces. The effects of facility ownership, geography, and region-specific political landscapes on LTC best-practice dissemination are examined. We used sociometric statistics and network sociograms, calculated from surveys with 169 senior leaders in LTC facilities, to identify advice-seeking network structures and to select 11 follow-up interview participants. Read More

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http://dx.doi.org/10.1017/S0714980820000057DOI Listing

Social participation and loneliness among older adults in Yazd, Iran.

Health Soc Care Community 2020 Jun 1. Epub 2020 Jun 1.

Department of Aging Health, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Social participation among older people is associated with more practice of physical activities, improvement of cognitive skills and less feeling of loneliness. The primary purpose of this cross-sectional study was to examine the social participation and sense of loneliness among older adults in Yazd, an Iranian city that is known for its traditional values and religious people. The non-probability sample consisted of 200 elderly people. Read More

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http://dx.doi.org/10.1111/hsc.13018DOI Listing

The association between frailty and detrusor overactivity in older adults.

Neurourol Urodyn 2020 Jun 1. Epub 2020 Jun 1.

Department of Urology, University of California-San Francisco, San Francisco, California.

Objective: To explore the relationship between frailty, age, and detrusor overactivity (DO) in older adults presenting to an academic urology practice.

Materials And Methods: This study uses the University of California, San Francisco Geriatric Urology Database to examine all adults ages ≥65 years who underwent urodynamic testing from December 2015 to April 2019. All subjects had a timed up and go test (TUGT) as a measure of frailty and were categorized as fast (≤10 seconds), intermediate (11-14 seconds), or slow (≥15 seconds), corresponding to not frail, pre-frail, and frail, respectively. Read More

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http://dx.doi.org/10.1002/nau.24414DOI Listing

Clinical practice guidelines adaptation for internists - An EFIM methodology.

Eur J Intern Med 2020 May 29. Epub 2020 May 29.

CIBERESP-IBIS-ROCIO-University Hospital; Fundación Enebro, Seville, Spain. Electronic address:

The rising number of clinical guidelines poses a new challenge to the internists. The main problems are: 1) available documents suffer from heterogeneous methodological quality, and 2) most of clinical guidelines target an 'ideal' patient affected by a single condition, while in real practice internists must face with comorbid patients typically undergoing a polypharmacy. To help address this challenge, EFIM Clinical Practice Working Group started a project aimed to answer a series of relevant clinical questions, by selecting the best available guidance containing recommendations applicable to complex patients under polypharmacy. Read More

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http://dx.doi.org/10.1016/j.ejim.2020.05.016DOI Listing

Understanding Respiratory Rate Assessment by Emergency Nurses: A Health Care Improvement Project.

J Emerg Nurs 2020 May 29. Epub 2020 May 29.

Introduction: Respiratory rate is the first sign of patient decline. Monitoring and recording respiratory rate are essential nursing competencies. However, health care system emergency nurses' ability to differentiate normal from abnormal respiratory rates was unknown. Read More

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http://dx.doi.org/10.1016/j.jen.2020.03.012DOI Listing

A compass for care: Evaluating first-year pharmacy students' philosophy of practice.

Curr Pharm Teach Learn 2020 Jun 19;12(6):656-662. Epub 2020 Feb 19.

Department of Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota College of Pharmacy, 211 Life Science, 1110 Kirby Dr, Duluth, MN 55812, United States. Electronic address:

Introduction: A philosophy of practice serves as the foundation for any patient care practice. Understanding the philosophies of practice held by students entering the profession is important as this presents potential opportunities for educators to help shape students' professional values/beliefs. The objective of this work was to evaluate how first-year pharmacy students (P1s) conceptualize their philosophy of practice as future pharmacists. Read More

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http://dx.doi.org/10.1016/j.cptl.2020.01.035DOI Listing

Otolaryngology in the Time of Corona: Assessing Operative Impact and Risk During the COVID-19 Crisis.

Otolaryngol Head Neck Surg 2020 Jun 2:194599820930214. Epub 2020 Jun 2.

Department of Otolaryngology-Head and Neck Surgery, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Objective: Limited research exists on the coronavirus disease 2019 (COVID-19) pandemic pertaining to otolaryngology-head and neck surgery (OHNS). The present study seeks to understand the response of OHNS workflows in the context of policy changes and to contribute to developing preparatory guidelines for perioperative management in OHNS.

Study Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1177/0194599820930214DOI Listing

Lung transplantation for pulmonary sarcoidosis.

Authors:
Meyer Keith C

Sarcoidosis Vasc Diffuse Lung Dis 2019 1;36(2):92-107. Epub 2019 May 1.

Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.

Although relatively few patients with pulmonary sarcoidosis develop advanced disease that progresses to respiratory insufficiency despite receiving best practice pharmacologic interventions, lung transplantation may be the only therapeutic option for such patients to both prolong survival and provide improved quality of life. Lung transplant can be successfully performed for patients with end-stage pulmonary sarcoidosis, and post-transplant survival is similar to that for other transplant indications such as idiopathic pulmonary fibrosis. However, appropriate timing of referral, comprehensive assessment of potential candidates for lung transplant, placement of patients on the lung transplant waiting list when within the transplant window as appropriate, choosing the best procedure (bilateral versus single lung transplant), and optimal peri-operative and post-transplant management are key to successful lung transplant outcomes for patients with sarcoidosis. Read More

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http://dx.doi.org/10.36141/svdld.v36i2.7163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247104PMC

Identification of European-wide clinical priorities for guideline development in the management of pre-invasive cervical disease.

Eur J Obstet Gynecol Reprod Biol 2020 May 19;251:36-41. Epub 2020 May 19.

Department of Gynaecological Oncology, University Hospitals of North Midlands, Newcastle Road, Stoke on Trent, ST4 6QG, UK. Electronic address:

Objective: Addressing management controversies in the treatment of pre-invasive cervical disease is a key priority for the European Federation for Colposcopy/European Society of Gynaecologic Oncology who aim to develop a practical handbook of European centred guidelines to address areas where there is a lack of high-quality evidence or identifiable practice variation. Clinical opinion across the EFC network was sought to identify topics likely to have the most impact on clinical practice for systematic review and development of practice recommendations.

Study Design: A scoping exercise comprising of a three-iteration modified Delphi with representation from each member society of the EFC was conducted in 2018. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.017DOI Listing

Umbilical cord-derived mesenchymal stem cells in neurodegenerative disorders: from literature to clinical practice.

Regen Med 2020 Jun 1. Epub 2020 Jun 1.

Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran 14177-44361, Iran.

Mesenchymal stem cells (MSCs) have provided a promising tool for cell therapy. Umbilical cord (UC) is one of the best sources of MSCs since its collection is noninvasive, and effortless, and the cells from this source are more capable and prolific. It has been proven that the differentiation, migration and protective properties of UC-MSCs are superior compared with other kinds of stem cells. Read More

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http://dx.doi.org/10.2217/rme-2019-0119DOI Listing

Getting Value From Electronic Health Records: Research Needed to Improve Practice.

Ann Intern Med 2020 Jun;172(11_Supplement):S130-S136

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (D.W.B.).

Electronic health records (EHRs) are now widely adopted in the United States, but health systems have barely begun using them to deliver high-value care. More directed and rigorous research is needed to fulfill the promise of EHRs to not only store information but also support the delivery of better care. This article describes 4 potential benefits of EHR-based research: improving clinical decisions, supporting triage decisions, enabling collaboration among the care team (including patients), and increasing productivity via automation of tasks. Read More

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http://dx.doi.org/10.7326/M19-0878DOI Listing

Using Electronic Health Record Portals to Improve Patient Engagement: Research Priorities and Best Practices.

Ann Intern Med 2020 Jun;172(11_Supplement):S123-S129

UCSF Department of Medicine, Center for Vulnerable Populations at Zuckerberg San Francisco General Hospital, San Francisco, California (C.R.L., A.G.C., U.S.).

Ninety percent of health care systems now offer patient portals to access electronic health records (EHRs) in the United States, but only 15% to 30% of patients use these platforms. Using PubMed, the authors identified 53 studies published from September 2013 to June 2019 that informed best practices and priorities for future research on patient engagement with EHR data through patient portals, These studies mostly involved outpatient settings and fell into 3 major categories: interventions to increase use of patient portals, usability testing of portal interfaces, and documentation of patient and clinician barriers to portal use. Interventions that used one-on-one patient training were associated with the highest portal use. Read More

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http://dx.doi.org/10.7326/M19-0876DOI Listing

Understanding Mississippi's Current Practices Concerning Autism Screening at 18 & 24 Months.

Soc Work Public Health 2020 Jun 1:1-15. Epub 2020 Jun 1.

University of North Carolina at Chapel Hill Medical School , Chapel Hill, North Carolina, USA.

Best practice recommendations by the American Academy of Pediatrics support routine screening for developmental delays in early childhood, specifically at 18 and 24 months for Autism Spectrum Disorder (ASD). During this critical developmental period, early identification and intervention are associated with best outcomes for ASD. Pediatricians perform a critical role in the early recognition of ASD, which can co-exist with other disorders further complicating the diagnosis. Read More

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http://dx.doi.org/10.1080/19371918.2020.1764431DOI Listing

Application of Oleanolic Acid and Its Analogues in Combating Pathogenic Bacteria / by a Two-Pronged Strategy of β-Lactamases and Hemolysins.

ACS Omega 2020 May 12;5(20):11424-11438. Epub 2020 May 12.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun 130062, China.

The rapid spread of β-lactamase-producing bacteria in clinical practice has increasingly deteriorated the performance of β-lactam antibiotics against such resistant strains. Thus, novel agents or strategies for the war against β-lactamase-producing bacteria, especially hypervirulent resistant bacteria (such as toxin-secreting ) carrying complex β-lactamases, are urgently needed. In this study, we found that the natural compound oleanolic acid (OA) and its analogues (especially corosolic acid (CA)) significantly inhibited the activity of important β-lactamases (NDM-1, KPC-2, and VIM-1) in Enterobacteriaceae and β-lactamases (β-lactamase N1) in . Read More

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http://dx.doi.org/10.1021/acsomega.0c00460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254530PMC

The Transformative Influence of La Varenne's (1651) on French Culinary Practice.

Authors:
Leon G Fine

Front Nutr 2020 28;7:42. Epub 2020 Apr 28.

Program in the History of Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

The current proliferation of modern cookbooks targeted to the public at large makes it impossible to conceive of there being any that could have had an overriding influence on culinary practice or eating preferences, even at a local level. However, when there was a historical absence of cookbooks for a half-century, as there was in France in the first half of the seventeenth century, it is argued herein that the advent of a single cookbook in 1651, by La Varenne, could have had a transformational influence on culinary practice over the ensuing half-century. The book went into more than 50 subsequent editions in the second half of the century. Read More

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http://dx.doi.org/10.3389/fnut.2020.00042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198804PMC

Washout Period for Pregnancy Post Isotretinoin Therapy.

Indian Dermatol Online J 2020 Mar-Apr;11(2):239-242. Epub 2020 Mar 9.

Dermatology, Venereology and Leprosy, The Venkat Center for Skin and Plastic Surgery - Post Graduate Training Center (Affiliated to RGUHS), Subbanna Garden, Bengaluru, Karnataka, India.

Introduction And Background: Isotretinoin is an oral medication used for the treatment of severe acne unresponsive to other medications. This drug is teratogenic and should be prescribed with appropriate caution in selected group of patients. The washout period for pregnancy post isotrenoin therapy has always been a topic of controversy. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_101_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247620PMC

Building Cancer Diagnosis Text to OncoTree Mapping Pipelines for Clinical Sequencing Data Integration and Curation.

AMIA Jt Summits Transl Sci Proc 2020 30;2020:440-448. Epub 2020 May 30.

Wake Forest Baptist Medical Center, Winston Salem, NC.

Precision oncology research seeks to derive knowledge from existing data. Current work seeks to integrate clinical and genomic data across cancer centers to enable impactful secondary use. However, integrated data reliability depends on the data curation method used and its systematicity. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233083PMC

Sharing is Caring: Exploring machine learning-enabled methods for regional medical imaging exchange using procedure metadata.

AMIA Jt Summits Transl Sci Proc 2020 30;2020:383-392. Epub 2020 May 30.

University of Toronto, Toronto, Ontario Canada.

Seamless sharing between imaging facilities of medical images obtained on the same patient is crucial in providing accurate and efficient care to patients. However, the terminology used to describe semantically similar examinations can vary widely between facilities. Current practice is manual table-based mapping to a standard terminology, which has substantial potential for mislabelled and missing examinations. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233030PMC

Natural Language Processing for the Evaluation of Methodological Standards and Best Practices of EHR-based Clinical Research.

AMIA Jt Summits Transl Sci Proc 2020 30;2020:171-180. Epub 2020 May 30.

Department of Health Sciences Research, Mayo Clinic, Rochester, MN.

The effective use of EHR data for clinical research is challenged by the lack of methodologic standards, transparency, and reproducibility. For example, our empirical analysis on clinical research ontologies and reporting standards found little-to-no informatics-related standards. To address these issues, our study aims to leverage natural language processing techniques to discover the reporting patterns and data abstraction methodologies for EHR-based clinical research. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233049PMC

Diagnostic and Therapeutic Potential of microRNAs in Acute Kidney Injury.

Front Pharmacol 2020 14;11:657. Epub 2020 May 14.

Division of Nephrology, University Hospital Zurich, Zurich, Switzerland.

During hospital stay, about 20% of adult patients experience an episode of acute kidney injury (AKI), which is characterized by a rapid decrease in kidney function. Diagnostic tools regarding early diagnosis of kidney dysfunction prior to AKI and markers of renal recovery are not available. Additionally, there is no therapeutic option for the treatment of AKI. Read More

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http://dx.doi.org/10.3389/fphar.2020.00657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240101PMC

Research nurses as practice facilitators to disseminate an asthma shared decision making intervention.

BMC Nurs 2020 18;19:40. Epub 2020 May 18.

1Atrium Health, Department of Family Medicine Research, 2001 Vail Avenue, Suite 400B Mercy Medical Plaza, Charlotte, NC 28207 USA.

Background: Practice facilitation is a method of introducing and sustaining organizational change. It involves the use of skilled healthcare professionals called practice facilitators (PFs) to help address the challenges associated with implementing evidence-based guidelines and complex interventions into practice. PFs provide a framework for translating research into practice by building relationships, improving communication, fostering change, and sharing resources. Read More

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http://dx.doi.org/10.1186/s12912-020-00414-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236364PMC

An Innovative Online Knowledge Translation Curriculum in Graduate Education.

Worldviews Evid Based Nurs 2020 Jun 1. Epub 2020 Jun 1.

Patient Family Engagement, BC Cancer, Vancouver, British Columbia, Canada.

Background: There is increased acknowledgment of the importance of knowledge translation (KT) in the role of graduate-prepared healthcare practitioners, such as nurses, as change agents in the mobilization of evidence-based knowledge. The offering of flexible educational programming online and hybrid course delivery in higher education is a response to insufficient didactic methods for providing graduate students with the competencies to facilitate KT.

Aims: To describe the development, implementation, and evaluation of a cohort-based, online, innovative KT curriculum using a theoretical approach to KT called the Knowledge-As-Action Framework, which focuses on the knower, knowledge, and context as being inseparable. Read More

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http://dx.doi.org/10.1111/wvn.12440DOI Listing

Ethnic inequality in non-steroidal anti-inflammatory drug-associated harm in New Zealand: A national population-based cohort study.

Pharmacoepidemiol Drug Saf 2020 May 31. Epub 2020 May 31.

Best Practice Advocacy Centre NZ, Dunedin, New Zealand.

Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with many serious complications and they are widely used in New Zealand (NZ). However, differences in NSAID-associated risk for these complications between ethnic groups are largely unknown. We assessed ethnic disparities in risk of hospital admission for upper gastrointestinal bleeding (UGIB), heart failure, and acute kidney failure (AKF) in NZ's primary care population prescribed and dispensed NSAIDs. Read More

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http://dx.doi.org/10.1002/pds.5028DOI Listing

Practice Recommendations for End-of-Life Care in the Intensive Care Unit.

Crit Care Nurse 2020 Jun;40(3):14-22

Ranveig Lind is an associate professor at UiT, the Arctic University of Norway, and a research nurse in the intensive care unit at University Hospital of North Norway, Tromsø, Norway.

Topic: A substantial number of patients die in the intensive care unit, so high-quality end-of-life care is an important part of intensive care unit work. However, end-of-life care varies because of lack of knowledge of best practices.

Clinical Relevance: Research shows that high-quality end-of-life care is possible in an intensive care unit. Read More

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http://dx.doi.org/10.4037/ccn2020834DOI Listing

Aligning Organizational Culture and Infrastructure to Support Evidence-Based Practice.

Crit Care Nurse 2020 Jun;40(3):59-63

Suzan R. Miller-Hoover is a nurse scientist and owner of SRMH Consulting, LLC, Pine, Arizona.

Standardized nursing practice based on the foundations of evidence-based practice leads to high-quality patient care and optimal outcomes. Despite knowing the benefits of evidence-based practice, health care organizations do not consistently make it the standard of care; thus, implementation of evidence-based practice at the system level continues to be challenging. This article describes the process adopted by a facility in the Southwest that took on the challenge of changing the organizational culture to incorporate evidence-based practice. Read More

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http://dx.doi.org/10.4037/ccn2020963DOI Listing

[Screening tools for cannabis use disorders and their adaptation to DSM-5: A literature review].

Encephale 2020 May 28. Epub 2020 May 28.

Université de Lorraine, Faculté de médecine, 54000 Nancy, France; Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France; Inserm U1114, Fédération de Médecine Translationnelle de Strasbourg, Département de Psychiatrie, Centre Hospitalier Régional Universitaire de Strasbourg, Strasbourg, France. Electronic address:

Objectives: Cannabis use is widespread in France, particularly among adolescents and young adults, and can induce severe somatic, psychiatric and social consequences. Early identification and appropriate care of cannabis use disorders thus constitute a major public health issue. Standardized questionnaires based on patient self-reporting are recognized as the best option for identifying cannabis use disorders because of their reliability and simplicity. Read More

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http://dx.doi.org/10.1016/j.encep.2020.02.010DOI Listing

Enablers and barriers of people with chronic musculoskeletal pain for engaging in telehealth interventions: protocol for a qualitative systematic review and meta-synthesis.

Syst Rev 2020 May 31;9(1):122. Epub 2020 May 31.

Masters and Doctoral Programs in Physical Therapy, Universidade Cidade São Paulo (UNICID), São Paulo, Brazil.

Background: Chronic musculoskeletal pain represents an enormous burden in society. Best-practice care for chronic musculoskeletal pain suggests adoption of self-management strategies. Telehealth interventions (e. Read More

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http://dx.doi.org/10.1186/s13643-020-01390-xDOI Listing

The Development of a Brief Version of the Insomnia Severity Index (ISI-3) in Older Adult Veterans with Posttraumatic Stress Disorder.

Behav Sleep Med 2020 Jun 1:1-11. Epub 2020 Jun 1.

Child and Adolescent Services Research Center , San Diego, California.

Objective/background: The Insomnia Severity Index (ISI) is an insomnia self-report measure used to identify individuals at risk for insomnia disorder. Although the full ISI is only seven questions, a briefer version would allow more efficient and pragmatic administration in routine practice settings. Reliable and valid brief measures can support measurement-based care. Read More

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http://dx.doi.org/10.1080/15402002.2020.1760278DOI Listing

Randomized Pragmatic Trial of Stroke Transitional Care: The COMPASS Study.

Circ Cardiovasc Qual Outcomes 2020 Jun 1:CIRCOUTCOMES119006285. Epub 2020 Jun 1.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill. (S.B.J., A.M.J., A.M.K.-N., L.H.M., W.D.R.).

Background The objectives of this study were to develop and test in real-world clinical practice the effectiveness of a comprehensive postacute stroke transitional care (TC) management program. Methods and Results The COMPASS study (Comprehensive Post-Acute Stroke Services) was a pragmatic cluster-randomized trial where the hospital was the unit of randomization. The intervention (COMPASS-TC) was initiated at 20 hospitals, and 20 hospitals provided their usual care. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.119.006285DOI Listing