178,119 results match your criteria Best Practice & Research Clinical Endocrinology & Metabolism[Journal]


The 5-Ws of immunotherapy in head and neck cancer.

Crit Rev Oncol Hematol 2020 Jun 30;153:103041. Epub 2020 Jun 30.

Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy.

The immune checkpoint inhibitors, a class of drugs able to block immune suppressive pathways in order to prime an anticancer immunity, revolutionized standard of care in platinum-refractory recurrent and/or metastatic head and neck carcinoma (R/M HNSCC). The PD-1/ PD-L1 axis is involved in the genesis, maintenance and progression of HNSCC and represents the target of checkpoint inhibitors. HNSCC is an immunosuppressive disease with a high inflammatory component in tumor microenvironment. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.103041DOI Listing

Clinical Use Of Biologics For Asthma Treatment By Allergy Specialists: A Questionnaire Survey.

Ann Allergy Asthma Immunol 2020 Jul 3. Epub 2020 Jul 3.

University of Cincinnati College of Medicine, Department of Internal Medicine; Division of Immunology/Allergy Section. Electronic address:

Background: Asthma is a heterogeneous disease with emerging phenotypes and endotypes. Currently, five distinct biologics are Food and Drug Administration (FDA)-approved as add-on therapy for difficult-to-control Type 2-high asthma. As allergy specialists manage a spectrum of diseases for which biologics may be appropriate, it is important to understand their prescribing patterns. Read More

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http://dx.doi.org/10.1016/j.anai.2020.06.041DOI Listing

Setting realistic goals for feeding infants when their mothers have suspected or confirmed COVID-19.

Acta Paediatr 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatrics (Neonatal Division), McMaster University, Hamilton, Ontario, Canada.

The pandemic is a stressful time for everyone, including mothers and healthcare providers who are concerned about the best and safest way to feed babies born to mothers with suspected or confirmed COVID-19. There is lack of consensus regarding mother-infant contact, unless the mother definitely has COVID-19 and even then there is a distinct lack of data to devise protocols for everyday clinical practice.. Read More

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http://dx.doi.org/10.1111/apa.15459DOI Listing

Update on evidence in craniomaxillofacial surgery.

Curr Opin Otolaryngol Head Neck Surg 2020 Aug;28(4):241-245

Department of Otolaryngology at SUNY Upstate Medical University, Syracuse, New York, USA.

Purpose Of Review: Evidence-based medicine underpins clinical practice. Ideally, our clinical decision-making stems from systematic reviews of randomized controlled trials. However, in practice, this is not often the case, and we must instead rely on the best available evidence. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000642DOI Listing

Alcoholics Anonymous and 12-Step Facilitation Treatments for Alcohol Use Disorder: A Distillation of a 2020 Cochrane Review for Clinicians and Policy Makers.

Alcohol Alcohol 2020 Jul 6. Epub 2020 Jul 6.

Veterans Affairs and Stanford University Medical Centers, Stanford University Stanford School of Medicine, Stanford, CA, USA.

Aims: A recently completed Cochrane review assessed the effectiveness and cost-benefits of Alcoholics Anonymous (AA) and clinically delivered 12-Step Facilitation (TSF) interventions for alcohol use disorder (AUD). This paper summarizes key findings and discusses implications for practice and policy.

Methods: Cochrane review methods were followed. Read More

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http://dx.doi.org/10.1093/alcalc/agaa050DOI Listing

Human papillomavirus vaccination: Good clinical practice recommendations from the Federation of Obstetric and Gynecological Societies of India.

J Obstet Gynaecol Res 2020 Jul 6. Epub 2020 Jul 6.

Breach Candy Hospital and Research Centre, Mumbai, India.

Human papillomavirus (HPV) vaccination offers an excellent prospect for the primary prevention of cervical cancer. The bivalent and quadrivalent vaccines are both available in India. The nonavalent vaccine is licensed but not yet available. Read More

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http://dx.doi.org/10.1111/jog.14345DOI Listing
July 2020
0.931 Impact Factor

Congenital Heart Disease Long-term Improvement in Functional hEalth (CHD LIFE): A partnership program to improve the long-term functional health of children with congenital heart disease in Queensland.

J Paediatr Child Health 2020 Jul 6. Epub 2020 Jul 6.

Queensland Children's Hospital, Children's Health Queensland, Brisbane, Queensland, Australia.

Children who undergo open-heart surgery in the first year of life for congenital heart disease (CHD) are at high-risk for impaired development across multiple domains. International recommendations include systematic periodic developmental surveillance into adolescence and the establishment of long-termfollow-up programmes. This article describes the establishment and evolution of the Queensland Paediatric Cardiac Service neurodevelopmental follow-up programme - CHD LIFE (Long-term Improvement in Functional hEalth). Read More

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http://dx.doi.org/10.1111/jpc.14935DOI Listing

Institutional variation in recovery after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: An opportunity for enhanced recovery pathways.

J Surg Oncol 2020 Jul 5. Epub 2020 Jul 5.

Department of Surgery, City of Hope National Medical Center, Duarte, California.

Background: Variations in care have been demonstrated both within and among institutions in many clinical settings. By standardizing perioperative practices, Enhanced Recovery After Surgery (ERAS) pathways reduce variation in perioperative care. We sought to characterize the variation in cytoreductive surgery (CRS)/heated intraperitoneal chemotherapy (HIPEC) perioperative practices among experienced US medical centers. Read More

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http://dx.doi.org/10.1002/jso.26099DOI Listing

An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group.

Eur Heart J 2020 Jul 6. Epub 2020 Jul 6.

Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London and Barts Heart Centre, London, UK.

This consensus document, a summary of the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI), appraises the importance of ischaemia with non-obstructive coronary arteries (INOCA). Angina pectoris affects approximately 112 million people globally. Up to 70% of patients undergoing invasive angiography do not have obstructive coronary artery disease, more common in women than in men, and a large proportion have INOCA as a cause of their symptoms. Read More

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http://dx.doi.org/10.1093/eurheartj/ehaa503DOI Listing

CLIF-C Organ Failure Score and Liver Volume Predict Prognosis in Steroid-Treated Severe Acute Autoimmune Hepatitis.

Hepatol Commun 2020 Jul 4;4(7):1019-1033. Epub 2020 May 4.

Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan.

Controversies and debates remain regarding the best management of severe acute-onset autoimmune hepatitis (SA-AIH) due to the lack of useful outcome or complication prediction systems. We conducted this clinical practice-based observational study to clarify whether Chronic Liver Failure Consortium Organ Failure scores (CLIF-C OFs) and the computed tomography-derived liver volume to standard liver volume (CTLV/SLV) ratio at admission to a tertiary transplant center can predict outcomes and complications due to infection. Thirty-four consecutive corticosteroid-treated patients with SA-AIH from 2007 to 2018 were included. Read More

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http://dx.doi.org/10.1002/hep4.1521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327221PMC

Endoscopic sedation practices of Greek gastroenterologists: a nationwide survey.

Ann Gastroenterol 2020 Jul-Aug;33(4):366-373. Epub 2020 May 15.

First Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece (Adonis A. Protopapas, Evangelos Stournaras, Georgios Neokosmidis, Dimitrios Stogiannou, Athanasios Filippidis, Andreas N. Protopapas).

Background: Sedation in gastrointestinal endoscopy is rapidly evolving worldwide. However, this has led to significant disagreements, especially regarding the use of propofol by non-anesthesiologists. The aim of this study was to document the practices of Greek gastroenterologists regarding sedation and compare them to previous surveys. Read More

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http://dx.doi.org/10.20524/aog.2020.0494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315718PMC

Nurses' decision-making about cancer patients' end-of-life skin care in Wales: an exploratory mixed-method vignette study protocol.

BMJ Open 2020 Jul 5;10(7):e034938. Epub 2020 Jul 5.

School of Healthcare Sciences, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom.

Introduction: Patients with cancer are at high risk of developing pressure ulcers at the end of life as a result of their underlying condition or cancer treatment. There are many guidelines which set out best practice with regard to end-of-life skin care. However, the complexity of palliative cancer care often means that it is challenging for nurses to make the appropriate person-centred decisions about end-of-life skin care. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034938DOI Listing

An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group.

EuroIntervention 2020 Jul 6. Epub 2020 Jul 6.

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University and Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.

This consensus document, a summary of the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI), appraises the importance of ischaemia with non-obstructive coronary arteries (INOCA). Angina pectoris affects approximately 112 million people globally. Up to 70% of patients undergoing invasive angiography do not have obstructive coronary artery disease, more common in women than in men, and a large proportion have INOCA as a cause of their symptoms. Read More

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http://dx.doi.org/10.4244/EIJY20M07_01DOI Listing

Treatment of Non-neurogenic Lower Urinary Tract Symptoms-A Review of Key Publications from 2018 Onward.

Eur Urol Focus 2020 Jul 2. Epub 2020 Jul 2.

Department of Urology, Hospital de S. João, Porto, Portugal; Faculty of Medicine, University of Porto, Porto, Portugal; i3S - IBMC - Instituto Investigação Inovação Saude, University of Porto, Porto, Portugal. Electronic address:

Context: A considerable number of studies addressing the management of lower urinary tract symptoms (LUTS) have been published since 2018.

Objective: To review the key studies involving pharmacological and neuromodulation treatment of LUTS published from 2018 onward.

Evidence Acquisition: We followed the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) statement. Read More

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http://dx.doi.org/10.1016/j.euf.2020.06.015DOI Listing

Canadian Cardiovascular Society Clinical Practice Update on the Assessment and Management of Syncope.

Can J Cardiol 2020 Jul 2. Epub 2020 Jul 2.

Department of Emergency Medicine, Queen's University, Kingston, Ontario, Canada.

Syncope is a symptom that occurs in multiple settings and has a variety of underlying causes, ranging from benign to life threatening. Determining the underlying diagnosis and prognosis can be challenging and often results in an unstructured approach to evaluation, which is ineffective and costly. In this first ever document, the Canadian Cardiovascular Society (CCS) provides a clinical practice update on the assessment and management of syncope. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.12.023DOI Listing

Academic electronic health records as a vehicle to augment the assessment of patient care skills in the didactic pharmacy curriculum.

Curr Pharm Teach Learn 2020 Sep 16;12(9):1056-1061. Epub 2020 Apr 16.

Ferris State University College of Pharmacy, 220 Ferris Drive, Big Rapids, MI 49307, United States. Electronic address:

Introduction: Standards 2016 state students must be "practice-ready" upon graduation and utilizing health information technology is one skill needed to ensure students are practice-ready. Incorporating academic electronic health records (EHRs) into the didactic pharmacy curriculum is one tool for preparing students to be practice-ready, but it is unclear if this technology is used to facilitate assessment of students' patient care skills.

Methods: A 35-question electronic survey was distributed to each school/college of pharmacy (S/COP) with questions focused on general use of EHRs and characterizing EHRs as a tool to assess students' patient care skills in the didactic curriculum. Read More

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http://dx.doi.org/10.1016/j.cptl.2020.04.004DOI Listing
September 2020

Translating Dysphagia Evidence into Practice While Avoiding Pitfalls: Assessing Bias Risk in Tracheostomy Literature.

Dysphagia 2020 Jul 4. Epub 2020 Jul 4.

School of Audiology and Speech Sciences, University of British Columbia, 2177 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.

Critically ill patients who require a tracheostomy often have dysphagia. Widespread practice guidelines have yet to be developed regarding the acute assessment and management of dysphagia in patients with tracheostomy. In order for clinicians to base their practice on the best available evidence, they must first assess the applicable literature and determine its quality. Read More

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http://dx.doi.org/10.1007/s00455-020-10151-wDOI Listing

Rhodococcus equi infection as inaugural manifestation of idiopathic CD4 lymphopenia: A rare entity and a therapeutic challenge.

Pulmonology 2020 Jul 1. Epub 2020 Jul 1.

Pulmonology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Rua Conceição Fernandes, 4434-502 Vila Nova de Gaia, Portugal.

We report a case of disseminated infection by Rhodococcus equi as the inaugural manifestation of idiopathic T-CD4 lymphopenia. We aim to demonstrate our diagnostic and therapeutic approach and focus on the major dilemmas arising from the lack of scientific evidence regarding best clinical practice of this infection in humans. Read More

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http://dx.doi.org/10.1016/j.pulmoe.2020.06.002DOI Listing

Tetralogy of Fallot.

Cardiol Clin 2020 Aug 10;38(3):365-377. Epub 2020 Jun 10.

Department of Cardiology, Boston Children's Hospital, Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Bader 208, Boston, MA 02115, USA. Electronic address:

Repaired tetralogy of Fallot is one of the most common conditions managed by adult congenital heart disease providers. Recent comprehensive review articles and book chapters are devoted to this topic. The purpose of this article is to address several common clinical questions encountered in the management of patients with repaired tetralogy of Fallot. Read More

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http://dx.doi.org/10.1016/j.ccl.2020.04.009DOI Listing

(Fluoro)quinolones and quinolone resistance genes in the aquatic environment: A river catchment perspective.

Water Res 2020 Jun 6;182:116015. Epub 2020 Jun 6.

Department of Chemistry, Faculty of Science, University of Bath, Bath, BA2 7AY, United Kingdom, UK. Electronic address:

This study provides an insight into the prevalence of (fluoro)quinolones (FQs) and their specific quinolone qnrS resistance gene in the Avon river catchment area receiving treated wastewater from 5 wastewater treatment plants (WWTPs), serving 1.5 million people and accounting for 75% of inhabitants living in the catchment area in the South West of England.. Read More

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http://dx.doi.org/10.1016/j.watres.2020.116015DOI Listing

Real-World Outcomes of DMEK: A Prospective Dutch Registry Study.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

University Eye Clinic, Maastricht University Medical Center+, Maastricht, the Netherlands.

Purpose: To analyze real-world practice patterns, graft survival, and outcomes of Descemet membrane endothelial keratoplasty (DMEK) in the Netherlands.

Design: Population-based interventional clinical study.

Methods: In this prospective registry study, all consecutive primary DMEK procedures registered in the Netherlands Organ Transplant Registry were identified. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.023DOI Listing

Developing a Measure of the Impact of COVID-19 Social Distancing on Household Conflict and Cohesion.

Fam Process 2020 Jul 4. Epub 2020 Jul 4.

School of Nursing and Health Studies, University of Miami, Coral Gables, Florida, United States.

This report introduces the COVID-19 Family Environment Scale (CHES), which aims to measure the impact of social distancing due to COVID-19 on household conflict and cohesion. Existing measures do not capture household experiences relevant to the pandemic, in which families are largely confined to their homes while sharing a life-threatening situation. Using best practice guidelines, we developed a pool of items and revised them with review by a panel of experts, and cognitive interviewing with community respondents. Read More

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http://dx.doi.org/10.1111/famp.12579DOI Listing

GOING TO WAR ON COVID19: MOBILIZING AN ACADEMIC NEPHROLOGY GROUP PRACTICE.

Nephrology (Carlton) 2020 Jul 4. Epub 2020 Jul 4.

Division of Nephrology, Department of Medicine, National University Health System, 1E Kent Ridge Road, Singapore.

Aims: The COVID-19 pandemic poses unprecedented operational challenges to nephrology divisions in every country as they cope with COVID-19-related kidney disease in addition to regular patient care. Although general approaches have been proposed, there is a lack of practical guidance for nephrology division response in a hospital facing a surge of cases. Here, we describe the specific measures that our division has taken in the hope that our experience in Singapore may be helpful to others METHODS: Descriptive narrative RESULTS: A compilation of operational responses to the COVID-19 pandemic taken by a nephrology division at a Singapore university hospital CONCLUSION: Nephrology operational readiness for COVID-19 requires a clinical mindset shift from usual standard of care to a crisis exigency model that targets best outcomes for available resources. Read More

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http://dx.doi.org/10.1111/nep.13753DOI Listing

Impact of bariatric surgery on oral anticoagulants pharmacology, and consequences for clinical practice: a narrative review.

Fundam Clin Pharmacol 2020 Jul 3. Epub 2020 Jul 3.

EA3878, Université de Bretagne Occidentale, Brest, France.

The prevalence of obesity has been steadily increasing in recent years worldwide. At the same time bariatric surgery, the best therapeutic strategy to date in terms of sustainable weight loss and improvement of associated comorbidities, has been also increasing. However, these surgeries, whether primarily restrictive or malabsorptive, raise questions about the pharmacology of oral drugs. Read More

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http://dx.doi.org/10.1111/fcp.12587DOI Listing

Opioids for breathlessness: a narrative review.

BMJ Support Palliat Care 2020 Jul 3. Epub 2020 Jul 3.

Wolfson Palliative Care Research Centre, University of Hull, Hull, Kingston upon Hull, UK.

Chronic breathlessness is a disabling and distressing condition for which there is a growing evidence base for a range of interventions. Non-pharmacological interventions are the mainstay of management and should be optimised prior to use of opioid medication. Opioids are being implemented variably in practice for chronic breathlessness. Read More

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http://dx.doi.org/10.1136/bmjspcare-2020-002314DOI Listing

Has Invisalign improved? A prospective follow-up study on the efficacy of tooth movement with Invisalign.

Am J Orthod Dentofacial Orthop 2020 Jun 30. Epub 2020 Jun 30.

Department of Orthodontics, European University College, Dubai Healthcare City, Dubai, United Arab Emirates.

Introduction: The purpose of this research was to provide an update on the accuracy of tooth movement with Invisalign (Align Technology, Santa Clara, Calif).

Methods: This prospective clinical study included 38 patients treated with Invisalign Full or Invisalign Teen. All teeth, from the central incisor to the second molar, were measured on digital models created from intraoral scans. Read More

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http://dx.doi.org/10.1016/j.ajodo.2019.12.015DOI Listing

Management of Intermittent and Persistent Asthma in Adolescent and High School Athletes.

J Allergy Clin Immunol Pract 2020 Jul - Aug;8(7):2166-2181

Program in Human Nutrition, Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Md.

Asthma is the most common chronic condition during childhood and adolescence, affecting an estimated 8% of children and youngsters below 18 years in the United States and the United Kingdom. In adolescent athletes, asthma-like symptoms may represent a common consequence of regular sport practice. Asthma in young athletes poses several challenges, including the ambiguity of definitions and diagnosis of asthma resulting from exercise-induced symptoms, the best pharmacological treatments, and the nonpharmacological options for the management of disease and the challenges inherent to this age group. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.05.003DOI Listing

A learning pharmacy practice enabled by the pharmacists' patient care process.

J Am Pharm Assoc (2003) 2020 Jun 30. Epub 2020 Jun 30.

Objective: The objective of this paper is to introduce the concept of a learning pharmacy practice and highlights a path toward a future practice focused on learning about medications from every patient with the support and insight of every pharmacist.

Summary: To address the Quintuple Aim of health care improvement, the profession of pharmacy is on the verge of a practice transformation that incorporates continuous learning from medication-related data into existing clinical and dispensing roles. The pharmacists' patient care process (PPCP) enables a learning pharmacy practice through the systematic and standardized collection of real-world medication-related data from pharmacists' patient care activities. Read More

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http://dx.doi.org/10.1016/j.japh.2020.05.013DOI Listing

Evidence-based healthcare, knowledge translation, implementation science and radiography: What does it all mean?

Radiography (Lond) 2020 Jun 30. Epub 2020 Jun 30.

JBI, University of Adelaide, Australia.

Evidence-based healthcare is an approach to practice whereby decision making and service delivery considers the best available evidence, patient choice, local resources and clinical expertise. Although sound in theory, compliance with evidence-based practice is often far from optimal. To address this, related fields such as knowledge translation and implementation science have emerged, which largely focus on methods and techniques to facilitate the transfer of evidence into practice. Read More

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http://dx.doi.org/10.1016/j.radi.2020.05.008DOI Listing

Evaluation and Management of Esophageal and Gastric Varices in Patients with Cirrhosis.

Clin Liver Dis 2020 Aug 31;24(3):335-350. Epub 2020 May 31.

Section of Digestive Diseases, Yale University School of Medicine, PO Box 208056, 333 Cedar Street, New Haven, CT 06520-8056, USA; Section of Digestive Diseases, VA Connecticut Healthcare System, West Haven, CT, USA.

Variceal bleeding is a complication of cirrhosis that defines decompensation. Important advances in the management of gastroesophageal varices have led to a significant decrease in the morbidity and mortality. Achieving these results in clinical practice is contingent on clinicians applying the best practice strategies and appropriate referral to a tertiary center. Read More

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http://dx.doi.org/10.1016/j.cld.2020.04.011DOI Listing

Factors Associated with Caregiving Appraisal of Informal Caregivers: A Systematic Review.

J Clin Nurs 2020 Jul 3. Epub 2020 Jul 3.

Johns Hopkins University School of Nursing, 525 N. Wolfe Street, Baltimore, Maryland, United States.

Aims And Objectives: To identify factors associated with the caregiving appraisal of informal caregivers.

Background: Caregiving appraisal, the cognitive evaluation of the caregiving situation, is an essential factor in determining positive or negative caregiving outcomes. Identifying factors associated with appraisal is fundamental for designing effective health promotion strategies. Read More

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http://dx.doi.org/10.1111/jocn.15394DOI Listing

Predictors of worsening neuropathy and neuropathic pain after 12 years in people with HIV.

Ann Clin Transl Neurol 2020 Jul 3. Epub 2020 Jul 3.

Departments of Medicine and Psychiatry, University of California, San Diego, La Jolla, California.

Objective: Distal sensory polyneuropathy (DSP) and neuropathic pain are important clinical concerns in virally suppressed people with HIV. We determined how these conditions evolved, what factors influenced their evolution, and their clinical impact.

Methods: Ambulatory, community-dwelling HIV seropositive individuals were recruited at six research centers. Read More

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http://dx.doi.org/10.1002/acn3.51097DOI Listing

Classic and emergent indicators for the assessment of human iron status.

Crit Rev Food Sci Nutr 2020 Jul 3:1-14. Epub 2020 Jul 3.

Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.

Iron deficiency is the leading cause of anemia, a significant global public health problem. Different methods exist for assessing iron nutritional status, including laboratory tests that focus on storage, transportation, and iron functional compartment parameters. Classical markers such as bone marrow, serum iron, ferritin, hemoglobin, erythrocyte parameters, transferrin, transferrin receptors, and zinc protoporphyrin are discussed in this review. Read More

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http://dx.doi.org/10.1080/10408398.2020.1787326DOI Listing

Pain relief and recovery after breast cancer surgery: translating best evidence into practice.

Anaesthesia 2020 Jul 3. Epub 2020 Jul 3.

Department of Anesthesiology and Pain Medicine, University of Ottawa, ON, Canada.

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http://dx.doi.org/10.1111/anae.15033DOI Listing

Update on evidence in craniomaxillofacial surgery.

Curr Opin Otolaryngol Head Neck Surg 2020 Jun 28. Epub 2020 Jun 28.

Department of Otolaryngology at SUNY Upstate Medical University, Syracuse, New York, USA.

Purpose Of Review: Evidence-based medicine underpins clinical practice. Ideally, our clinical decision-making stems from systematic reviews of randomized controlled trials. However, in practice, this is not often the case, and we must instead rely on the best available evidence. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000642DOI Listing

Primary Care Perceptions and Practices on Discussion and Advice Regarding Sexual Practices.

South Med J 2020 Jul;113(7):356-359

From the Department of Family Medicine, Mayo Clinic, Jacksonville, Florida.

Objectives: The United States has experienced an increase in sexually transmitted infections (STIs) in the past decade, a trend that may be influenced by communication gaps between family physicians and patients. We sought to identify factors that hinder discussion about safe sexual practices and STIs, understand physicians' perceptions of their role in preventing STIs, and explore methods of initiating discussions on sexual health.

Methods: From April 30, 2016 to September 1, 2016, family physicians at our institution were given written surveys with 22 questions to answer and rank in order of their best practice. Read More

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http://dx.doi.org/10.14423/SMJ.0000000000001114DOI Listing

Recognizing, reporting and reducing the data curation debt of cohort studies.

Int J Epidemiol 2020 Jul 2. Epub 2020 Jul 2.

Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Good data curation is integral to cohort studies, but it is not always done to a level necessary to ensure the longevity of the data a study holds. In this opinion paper, we introduce the concept of data curation debt-the data curation equivalent to the software engineering principle of technical debt. Using the context of UK cohort studies, we define data curation debt-describing examples and their potential impact. Read More

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http://dx.doi.org/10.1093/ije/dyaa087DOI Listing

Achieving accurate estimates of fetal gestational age and personalised predictions of fetal growth based on data from an international prospective cohort study: a population-based machine learning study.

Lancet Digit Health 2020 Jul 23;2(7):e368-e375. Epub 2020 Jun 23.

Department of Physics, University of Wisconsin, Milwaukee, WI, USA.

Background: Preterm birth is a major global health challenge, the leading cause of death in children under 5 years of age, and a key measure of a population's general health and nutritional status. Current clinical methods of estimating fetal gestational age are often inaccurate. For example, between 20 and 30 weeks of gestation, the width of the 95% prediction interval around the actual gestational age is estimated to be 18-36 days, even when the best ultrasound estimates are used. Read More

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http://dx.doi.org/10.1016/S2589-7500(20)30131-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323599PMC

Endocrine Surgery during the COVID-19 Pandemic: Recommendations from the Turkish Association of Endocrine Surgery.

Sisli Etfal Hastan Tip Bul 2020 16;54(2):117-131. Epub 2020 Jun 16.

Department of General Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

The 2019 novel coronavirus disease (COVID-19) was initially seen in Wuhan, China, in December 2019. World Health Organization classified COVID-19 as a pandemic after its rapid spread worldwide in a few months. With the pandemic, all elective surgeries and non-emergency procedures have been postponed in our country, as in others. Read More

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http://dx.doi.org/10.14744/SEMB.2020.65902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326680PMC

EMQN best practice guidelines for molecular genetic testing and reporting of 21-hydroxylase deficiency.

Eur J Hum Genet 2020 Jul 2. Epub 2020 Jul 2.

Bioglobe GmbH, Grandweg 64, D-22529, Hamburg, Germany.

Molecular genetic testing for congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) is offered worldwide and is of importance for differential diagnosis, carrier detection and adequate genetic counseling, particularly for family planning. In 2008 the European Molecular Genetics Quality Network (EMQN) for the first time offered a European-wide external quality assessment scheme for CAH (due to 21-OH deficiency). The interest was great and over the last years at about 60 laboratories from Europe, USA and Australia regularly participated in that scheme. Read More

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http://dx.doi.org/10.1038/s41431-020-0653-5DOI Listing

Effects of physical exercise in sarcopenia. A systematic review.

Endocrinol Diabetes Nutr 2020 Jun 29. Epub 2020 Jun 29.

Unidad de Nutrición Clínica y Dietética, Departamento de Endocrinología y Nutrición, Complejo Asistencial Universitario de León, León, España.

From the third decade of life and due to multiple causes, muscle mass and strength are gradually lost, which affects the function of the musculoskeletal system. This combined loss of muscle mass and strength with aging is called sarcopenia, and is associated with greater morbidity and mortality in the elderly. Early treatment is therefore essential, and physical exercise is the therapeutic approach that has given the best results. Read More

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http://dx.doi.org/10.1016/j.endinu.2020.02.010DOI Listing

Why isn't there an evidence-based radiography? Reflections and a call to action.

Authors:
Z Munn

Radiography (Lond) 2020 Jun 29. Epub 2020 Jun 29.

JBI, The University of Adelaide, 55 King William Road, SA 5005, Australia. Electronic address:

In an ideal world all healthcare professionals (including radiographers and medical radiation professionals) would deliver care based on the best available evidence, ensuring best outcomes and optimal use of resources. Unfortunately, we know this is often not the case. This article calls for structural changes to enable the development of an evidence-based radiography. Read More

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http://dx.doi.org/10.1016/j.radi.2020.05.005DOI Listing

Best Practices in Patient Safety and Communication.

Emerg Med Clin North Am 2020 Aug 8;38(3):693-703. Epub 2020 Jun 8.

Massachusetts General Hospital, 55 Fruit Street, Bulfinch 290, Boston, MA 02114, USA.

Emergency medicine is a high-risk area of medical practice, with a high rate of preventable adverse events. This is multifactorial, hinging on the myriad system and processes issues that complicate emergency care. Strong teamwork and communication have been identified as critical components for safe care in emergency medicine. Read More

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http://dx.doi.org/10.1016/j.emc.2020.04.007DOI Listing

Change in opioid policies in New England emergency departments, 2014 vs 2018.

Drug Alcohol Depend 2020 Jun 10;213:108105. Epub 2020 Jun 10.

Department of Emergency Medicine, Massachusetts General Hospital, 125 Nashua St., Suite 920, Boston, MA 02114, United States. Electronic address:

Objective: The U.S. opioid epidemic persists, yet it is unclear if opioid-related emergency department (ED) policies have changed. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2020.108105DOI Listing

Dietary therapy for eosinophilic esophagitis: chances and limitations in the clinical practice.

Expert Rev Gastroenterol Hepatol 2020 Jul 2. Epub 2020 Jul 2.

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) , Spain.

Introduction: Eosinophilic esophagitis (EoE) is a non-IgE-mediated food allergy that currently represents the main cause of dysphagia and food impaction in children and young adults. Diet remains the only therapy targeting the cause of the disease. Relevant advances in recent years allow novel approaches to dietary therapy in EoE. Read More

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http://dx.doi.org/10.1080/17474124.2020.1791084DOI Listing

Exploring the use of curbside consultations for interprofessional collaboration and clinical decision-making.

J Interprof Care 2020 Jul 2:1-8. Epub 2020 Jul 2.

Nursing, University of Texas at Austin , Austin, TX, USA.

Nurse practitioners utilize curbside consultation, an interprofessional collaboration communication process in which one clinician seeks advice from another, in clinical decision-making practices. Nevertheless, this process is not well-understood. A qualitative design with individual open-ended interviews was used to explore the phenomenon of curbside consultation among nurse practitioners for clinical decision-making. Read More

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http://dx.doi.org/10.1080/13561820.2020.1768057DOI Listing

Decontamination Methods for Reuse of Filtering Facepiece Respirators.

JAMA Otolaryngol Head Neck Surg 2020 Jul 2. Epub 2020 Jul 2.

Department of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles.

Importance: The novel coronavirus disease 2019 (COVID-19) has proven to be highly infectious, putting health care professionals around the world at increased risk. Furthermore, there are widespread shortages of necessary personal protective equipment (PPE) for these individuals. Filtering facepiece respirators, such as the N95 respirator, intended for single use, can be reused in times of need. Read More

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http://dx.doi.org/10.1001/jamaoto.2020.1423DOI Listing

Therapy options after CDK4/6 inhibitors for HR+, HER2- postmenopausal metastatic/recurrent breast cancer in Japan: a role for mammalian target of rapamycin inhibitors?

Future Oncol 2020 Jul 2. Epub 2020 Jul 2.

Medical Oncology, Osaka International Cancer Institute, Osaka, Japan.

Despite advances in the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer, the disease is rarely curable. In this review, we focus on the use of cyclin-dependent kinase (CDK) 4/6 inhibitors, examining clinical experience and the mechanisms underlying the development of resistance, and evaluating treatment options after failure to respond to CDK4/6 inhibitors. Current basic research supports the use of mammalian target of rapamycin inhibitors after CDK4/6 inhibitor failure; however, more data are needed, particularly regarding treatment sequencing. Read More

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http://dx.doi.org/10.2217/fon-2020-0326DOI Listing

Mapping clinical outcomes to generic preference-based outcome measures: development and comparison of methods.

Health Technol Assess 2020 Jun;24(34):1-68

Centre for Health Economics, University of York, York, UK.

Background: Cost-effectiveness analysis using quality-adjusted life-years as the measure of health benefit is commonly used to aid decision-makers. Clinical studies often do not include preference-based measures that allow the calculation of quality-adjusted life-years, or the data are insufficient. 'Mapping' can bridge this evidence gap; it entails estimating the relationship between outcomes measured in clinical studies and the required preference-based measures using a different data set. Read More

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http://dx.doi.org/10.3310/hta24340DOI Listing