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Cortical thickness correlates of cognitive performance in cognitively-matched individuals with and without schizophrenia.

Brain Cogn 2019 Apr 17;132:129-137. Epub 2019 Apr 17.

Department of Psychology, York University, Toronto, ONT, Canada.

Schizophrenia is characterized by psychosis and, in most cases, cognitive impairment. It is unclear, however, whether these elements of the disorder represent distinct or related disease processes. Accordingly, this study investigated 3-way interactions between group, cognition and cortical thickness in cognitively-matched patients with schizophrenia and healthy control groups. Read More

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http://dx.doi.org/10.1016/j.bandc.2019.04.003DOI Listing

Ranking of stroke and cardiovascular risk factors for an optimal risk calculator design: Logistic regression approach.

Comput Biol Med 2019 Mar 25;108:182-195. Epub 2019 Mar 25.

Stroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA, USA. Electronic address:

Purpose: Conventional cardiovascular risk factors (CCVRFs) and carotid ultrasound image-based phenotypes (CUSIP) are independently associated with long-term risk of cardiovascular (CV) disease. In this study, 26 cardiovascular risk (CVR) factors which consisted of a combination of CCVRFs and CUSIP together were ranked. Further, an optimal risk calculator using AtheroEdge composite risk score (AECRS1. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.020DOI Listing

Lymph node fine-needle cytology in the era of personalized medicine. Is there a role?

Cytopathology 2019 Apr 20. Epub 2019 Apr 20.

Universita degli Studi di Salerno, Medicine and Surgery, Fisciano, Campania, IT.

The 2016 WHO revised classification of lymphoma has sub-classified well defined entities and added a number of provisional entities on the basis of new knowledge on genetic, epigenetics and phenotypical data; prognostic and predictive features are also part of this classification. New knowledge on well-defined entities further enlightens the mechanisms of lymphomagenesis, which are more complex and multifactorial than once believed. Therapies are also more complex because traditional clinical trials have been integrated with new drugs and compounds with unique mechanisms of actions against distinct molecular targets. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cyt.12708
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http://dx.doi.org/10.1111/cyt.12708DOI Listing
April 2019
1 Read

Serum levels of immunoglobulin G and complement 3 differentiate non-diabetic renal disease from diabetic nephropathy in patients with type 2 diabetes mellitus.

Acta Diabetol 2019 Apr 19. Epub 2019 Apr 19.

Division of Nephrology, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.

Aims: Heavy proteinuria caused by non-diabetic renal disease (NDRD) is common in type 2 diabetes mellitus (T2DM). The aim of this study was to investigate specific predictors for NDRD in addition to traditional indicators in T2DM.

Methods: A total of 341 patients with T2DM who underwent renal biopsy were retrospectively included. Read More

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http://dx.doi.org/10.1007/s00592-019-01339-0DOI Listing

On the simulation of mitral valve function in health, disease, and treatment.

J Biomech Eng 2019 Apr 20. Epub 2019 Apr 20.

Gorman Cardiovascular Research Group, Department of Surgery, University of Pennsylvania, Philadelphia, PA.

The mitral valve (MV) is the heart valve that regulates blood ?ow between the left atrium and left ventricle (LV). In situations where the MV fails to fully cover the left atrioventricular ori?ce during systole, the resulting regurgitation causes pulmonary congestion, leading to heart failure and/or stroke. The causes of MV insuf?ciency can be either primary (e. Read More

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http://dx.doi.org/10.1115/1.4043552DOI Listing

Validation of a freehand technique for cortical bone trajectory screws in the lumbar spine.

J Neurosurg Spine 2019 Apr 19:1-8. Epub 2019 Apr 19.

1Division of Orthopaedic Surgery, University of Toronto, Toronto.

OBJECTIVEThe cortical bone trajectory (CBT) technique for pedicle screw placement has gained popularity among spinal surgeons. It has been shown biomechanically to provide better fixation and improved pullout strength compared to a traditional pedicle screw trajectory. The CBT technique also allows for a less invasive approach for fusion and may have lower incidence of adjacent-level disease. Read More

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https://thejns.org/view/journals/j-neurosurg-spine/aop/artic
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http://dx.doi.org/10.3171/2019.1.SPINE181402DOI Listing
April 2019
1 Read

Brain volumes and their ratios in Alzheimer´s disease on magnetic resonance imaging segmented using Freesurfer 6.0.

Psychiatry Res Neuroimaging 2019 Mar 19;287:70-74. Epub 2019 Mar 19.

National Institute of Mental Health, Topolová 748, Klecany 250 67, Czechia; Institute of Clinical and Experimental Medicine, Czechia.

Ratios between opposing volumes from brain magnetic resonance imaging (MRI) can provide additional information to volumes in Alzheimer's disease (AD). Brain three-dimensional MPRAGE MRI at 3T were segmented into 44 regions using FreeSurfer v6 in 75 participants. The region's size in absolute volumes and relative proportions to the whole brain volume were compared between 39 AD patients and 36 age-, education- and sex-matched normal controls (NC). Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.01.014DOI Listing

Chronic cough and gastroesophageal reflux in children - CHEST Guideline and Expert Panel Report.

Chest 2019 Apr 16. Epub 2019 Apr 16.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, UMass Memorial Medical Center, Worcester, MA, USA.

Background: Whether gastroesophageal reflux (GER) or GER disease (GERD) causes chronic cough in children is controversial. Using the PICO format, we undertook 4 systematic reviews. For children with chronic cough (>4-weeks duration) and without underlying lung disease: (1) who do not have gastrointestinal GER symptoms, should empirical treatment for GERD be used? (2) with gastrointestinal GER symptoms, does treatment for GERD resolve the cough? (3) with or without gastrointestinal GER symptoms, what GER-based therapies should be used and for how long? (4) if GERD is suspected as the cause, what investigations and diagnostic criteria best determine GERD as the cause of the cough?

Methods: We used the CHEST Expert Cough Panel's protocol and American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00123692193083
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http://dx.doi.org/10.1016/j.chest.2019.03.035DOI Listing
April 2019
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Developing a new intelligent system for the diagnosis of oral medicine with case-based reasoning approach.

Oral Dis 2019 Apr 19. Epub 2019 Apr 19.

Department of Oral and Maxillofacial Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Since the clinical manifestations of many oral diseases can be quite similar despite the wide variety in etiology and pathology, the differential diagnosis of oral diseases is a complex and challenging process. Intelligent system for differential diagnosis of oral medicine using the artificial intelligence (AI) capabilities, helps specialists in achieving differential diagnosis in a wide range of oral diseases.

Materials And Methods: First, the essential data elements to design and develop an intelligent system were identified in a cross-sectional descriptive study. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13108
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http://dx.doi.org/10.1111/odi.13108DOI Listing
April 2019
1 Read

Neuroprotective Effects of Zafirlukast, Piracetam and Their Combination on L-Methionine-Induced Vascular Dementia in Rats.

Fundam Clin Pharmacol 2019 Apr 18. Epub 2019 Apr 18.

Pharmacology Department, October University for Modern Science and Arts, 11787, 6, October City, Egypt.

Vascular dementia is considered a vascular cognitive impairment disease caused by neuronal degeneration in the brain. Several studies have supported the hypothesis that oxidative stress and endothelial dysfunction are the main pathogenic factors in vascular dementia. This current study aims to determine the possible neuroprotective effects of zafirlukast, piracetam and the combination of piracetam and zafirlukast on L-methionine-induced vascular dementia in rats. Read More

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http://dx.doi.org/10.1111/fcp.12473DOI Listing

Improving follow up after predictive testing in Huntington's disease: evaluating a genetic counselling narrative group session.

J Community Genet 2019 Apr 18. Epub 2019 Apr 18.

Division of Evolution and Genomic Sciences, School of Biological Science, University of Manchester, Manchester, UK.

Recently updated Huntington's disease (HD) predictive testing guidelines emphasise clinicians' responsibility to facilitate emotional support following testing, regardless of the result. Yet models of post-test counselling support are poorly defined. Moreover, it is unclear how these might be best delivered. Read More

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http://dx.doi.org/10.1007/s12687-019-00416-9DOI Listing
April 2019
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Predictive Power of PEN-3 Model Constructs in Breast Cancer Screening Behaviors among Teachers: A Cross- Sectional Study in Central Iran.

Eur J Breast Health 2019 Apr 1;15(2):105-110. Epub 2019 Apr 1.

Department of Epidemiology and Biostatistics, Isfahan University of Medical Sciences, Isfahan, Iran.

Objective: Identifying the factors influencing screening is necessary to promote early detection of breast cancer. This study aims to determine the predictive power of PEN-3 model structures in breast cancer screening behaviors among teachers of Isfahan city in Iran.

Materials And Methods: This cross-sectional study was conducted on 192 female teachers in Isfahan selected by the multi-stage random sampling method. Read More

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http://www.eurjbreasthealth.com/eng/makale/685/59/Full-Text
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http://dx.doi.org/10.5152/ejbh.2019.4417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456271PMC
April 2019
1 Read

Concordance between the Different Cardiovascular Risk Scores in People with Rheumatoid Arthritis and Psoriasis Arthritis.

Cardiol Res Pract 2019 14;2019:7689208. Epub 2019 Mar 14.

Clinical Epidemiology and Biostatistics Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña, Hotel de Pacientes 7 Planta, C/As Xubias de Arriba, 84, 15006 A Coruña, Spain.

Aim: To determine the cardiovascular risk and the concordance between the different scores in people with rheumatoid arthritis (RA) and psoriatic arthritis (PsA).

Methods: Observational descriptive study of prevalence. Performed in the Rheumatology Service and the Clinical Epidemiology and Biostatistics Unit of the University Hospital Complex of A Coruña (Spain). Read More

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http://dx.doi.org/10.1155/2019/7689208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437736PMC

Intra- and Inter-observer Variability in Different Methods of Measuring Carpal Collapse.

Malays Orthop J 2019 Mar;13(1):20-24

Department of Hand Surgery, Ganga Hospital, Coimbatore, India.

Carpal collapse of wrist occurs in disorders like rheumatoid arthritis and Kienbock's disease. Three techniques have been described to measure carpal collapse. First, the carpal height ratio (CHR), measured by dividing carpal height by 3rd metacarpal length. Read More

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http://www.morthoj.org/2019/v13n1/measuring-carpal-collapse.
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http://dx.doi.org/10.5704/MOJ.1903.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459038PMC
March 2019
1 Read

Biomarkers in Motor Neuron Disease: A State of the Art Review.

Front Neurol 2019 3;10:291. Epub 2019 Apr 3.

Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom.

Motor neuron disease can be viewed as an umbrella term describing a heterogeneous group of conditions, all of which are relentlessly progressive and ultimately fatal. The average life expectancy is 2 years, but with a broad range of months to decades. Biomarker research deepens disease understanding through exploration of pathophysiological mechanisms which, in turn, highlights targets for novel therapies. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00291
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http://dx.doi.org/10.3389/fneur.2019.00291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456669PMC
April 2019
1 Read

Corrosive injuries of the upper gastrointestinal tract: A pictorial review of the imaging features.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):6-13

Department of Gastroenterology, Postgraduate Institute of Medical Imaging and Research (PGIMER), Chandigarh, India.

Corrosive ingestion is a common form of poisoning. Corrosive agents cause severe damage to the gastrointestinal (GI) tract. The most severe forms of injury can lead to mortality; however, the major concern with this type of injury is life-long morbidity. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_349_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467036PMC

Recent trends in the treatment of unresectable stage III non-small-cell lung cancer.

Respir Investig 2019 Apr 15. Epub 2019 Apr 15.

Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan.

Approximately 20-25% of non-small-cell lung cancer (NSCLC) is diagnosed when the disease has progressed to clinical stage III. At this stage, and even if the cancer is considered unresectable, the treatment strategy should aim to achieve a cure. At the time of the initial diagnosis, it is necessary for medical oncologists to devise the best treatment strategy for each patient by composing a multidisciplinary treatment team including thoracic surgeons and radiation oncologists. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22125345183024
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http://dx.doi.org/10.1016/j.resinv.2019.03.004DOI Listing
April 2019
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mpMRI preoperative staging in men treated with antiandrogen and androgen deprivation therapy before robotic prostatectomy.

Urol Oncol 2019 Apr 15. Epub 2019 Apr 15.

Laboratory for Genitourinary Cancer Pathogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address:

Introduction: Using multiparametric magnetic resonance imaging (mpMRI), we sought to preoperatively characterize prostate cancer (PCa) in the setting of antiandrogen plus androgen deprivation therapy (AA-ADT) prior to robotic-assisted radical prostatectomy (RARP). We present our preliminary findings regarding mpMRI depiction of changes of disease staging features and lesion appearance in treated prostate.

Methods: Prior to RARP, men received 6 months of enzalutamide and goserelin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10781439193001
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http://dx.doi.org/10.1016/j.urolonc.2019.01.012DOI Listing
April 2019
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Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer.

BMC Bioinformatics 2019 Apr 18;20(Suppl 4):119. Epub 2019 Apr 18.

geneXplain GmbH, 38302, Wolfenbüttel, Germany.

Background: The search for molecular biomarkers of early-onset colorectal cancer (CRC) is an important but still quite challenging and unsolved task. Detection of CpG methylation in human DNA obtained from blood or stool has been proposed as a promising approach to a noninvasive early diagnosis of CRC. Thousands of abnormally methylated CpG positions in CRC genomes are often located in non-coding parts of genes. Read More

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http://dx.doi.org/10.1186/s12859-019-2687-7DOI Listing

Synergistic Effects of Plant Derivatives and Conventional Chemotherapeutic Agents: An Update on the Cancer Perspective.

Medicina (Kaunas) 2019 Apr 17;55(4). Epub 2019 Apr 17.

Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.

Synergy is a process in which some substances cooperate to reach a combined effect that is greater than the sum of their separate effects. It can be considered a natural "straight" strategy which has evolved by nature to obtain more efficacy at low cost. In this regard, synergistic effects may be observed in the interaction between herbal products and conventional drugs or biochemical compounds. Read More

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http://dx.doi.org/10.3390/medicina55040110DOI Listing

Radical chest wall resection and modified reconstruction technique for solitary internal mammary lymph node recurrence in breast cancer.

Int J Surg Case Rep 2019 Apr 6;58:26-29. Epub 2019 Apr 6.

Department of Thoracic Surgery and Oncology, King Fahad Specialist Hospital Dammam, Saudi Arabia.

Introduction: Although the incidence of internal mammary lymph node recurrence rate in breast cancer is low but still it is the second most common drainage site after axilla. Patients with solitary internal mammary lymph node (IMLN) recurrence have overall better prognosis. The role of chemo and radiotherapy in internal mammary lymph node involvement with breast cancer is still controversial. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.021DOI Listing
April 2019
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Longitudinal Clinical Follow-up and Genetic Spectrum of Patients With Rod-Cone Dystrophy Associated With Mutations in PDE6A and PDE6B.

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Sorbonne Université, Institut national de la santé et de la recherche médicale, Centre national de la recherche scientifique, Institut de la Vision, Paris, France.

Importance: A precise phenotypic characterization of retinal dystrophies is needed for disease modeling as a basis for future therapeutic interventions.

Objective: To compare genotype, phenotype, and structural changes in patients with rod-cone dystrophy (RCD) associated with mutations in PDE6A or PDE6B.

Design, Setting, And Participants: In a retrospective cohort study conducted in Paris, France, from January 2007 to September 2017, 54 patients from a cohort of 1095 index patients with RCD underwent clinical examination, including personal and familial history, best-corrected visual acuity (BCVA), color vision, slitlamp examination, full-field electroretinography, kinetic visual fields (VFs), retinophotography, optical coherence tomography, near-infrared fundus autofluorescence, and short-wavelength fundus autofluorescence imaging. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2018.6367DOI Listing

Detection of anti-Trypanosoma cruzi antibodies by chimeric antigens in chronic Chagas disease-individuals from endemic South American countries.

PLoS One 2019 18;14(4):e0215623. Epub 2019 Apr 18.

Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.

Background: Laboratory diagnosis of chronic Chagas disease is a troubling factor due to lack of reference tests. The WHO suggests the use of two distinct commercial serological tests in parallel. The performance of commercial immunoassays might fluctuate depending on the antigenic matrices and the local strains of T. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215623PLOS

Identifying chronic thromboembolic pulmonary hypertension through the French national hospital discharge database.

PLoS One 2019 18;14(4):e0214649. Epub 2019 Apr 18.

Bayer AG, Berlin, Germany.

Chronic thromboembolic pulmonary hypertension (CTEPH), a rare pulmonary vascular disease, is often misdiagnosed due to nonspecific symptoms. The objective of the study was to develop, refine and validate a case ascertainment algorithm to identify CTEPH patients within the French exhaustive hospital discharge database (PMSI), and to use it to estimate the annual number of hospitalized patients with CTEPH in France in 2015, as a proxy for disease prevalence. As ICD-10 coding specifically for CTEPH was not available at the time of the study, a case ascertainment algorithm was developed in close collaboration with an expert committee, using a two-step process (refinement and validation), based on matched data from PMSI and hospital medical records from 2 centres. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214649PLOS
April 2019
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Adverse Outcomes After Bile Spillage in Incidental Gallbladder Cancers: A Population-based Study.

Ann Surg 2019 Apr 13. Epub 2019 Apr 13.

Department of Surgery, University of Calgary, Calgary, Alberta, Canada.

Objective: To determine the effect of bile spillage during cholecystectomy on oncological outcomes in incidental gallbladder cancers.

Background: Gallbladder cancer (GBC) is rare, but lethal. Achieving complete resection offers the best chance of survival. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003325DOI Listing

A Single-Channel EEG-Based Approach to Detect Mild Cognitive Impairment via Speech-Evoked Brain Responses.

IEEE Trans Neural Syst Rehabil Eng 2019 Apr 18. Epub 2019 Apr 18.

Mild Cognitive Impairment (MCI) is the preliminary stage of dementia, which may lead to Alzheimer's disease (AD) in the elderly people. Therefore, early detection of MCI has the potential to minimize the risk of AD by ensuring the proper mental health care before it is too late. In this study, we demonstrate a single-channel EEG based MCI detection method, which is cost-effective and portable, and thus suitable for regular home-based patient monitoring. Read More

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http://dx.doi.org/10.1109/TNSRE.2019.2911970DOI Listing
April 2019
5 Reads

Modeling spatial distribution of as the main reservoir host of zoonotic cutaneous leishmaniasis in northeastern Iran.

J Vector Borne Dis 2018 Oct-Dec;55(4):297-304

Department of Epidemiology and Biostatistics, Kerman University of Medical Sciences, Kerman, Iran.

Background & Objectives: Zoonotic cutaneous leishmaniasis (ZCL) is among the most endemic zoonotic diseases in Golestan Province of Iran. The aim of this study was to find the high risk areas of this infection by considering the distribution of reservoirs and human infection.

Methods: A cross-sectional study was conducted, in which Rhombomys opimus (Gerbils) were captured from different collection sites across the Golestan Province, Iran. Read More

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http://dx.doi.org/10.4103/0972-9062.256565DOI Listing
April 2019
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A novel splicing mutation of PTCH1 in a Chinese family with nevoid basal cell carcinoma syndrome.

Med Mol Morphol 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disease characterized by the development of multiple jaw keratocysts and basal cell carcinomas (BCC) and accompanied by diverse phenotypes. The establishment of diagnosis lies on the identification of a heterozygous germline pathogenic variant in the patched homolog 1 gene (PTCH1). PTCH1 has alternative splicing and selective initial coding exon, leading to three types of encoding proteins (PTCHL, PTCHM and PTCHS). Read More

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http://link.springer.com/10.1007/s00795-019-00222-9
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http://dx.doi.org/10.1007/s00795-019-00222-9DOI Listing
April 2019
1 Read

Factors associated with health-related quality of life among adults with tetralogy of Fallot.

Open Heart 2019 27;6(1):e000932. Epub 2019 Feb 27.

Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

Background: Due to improved care, the numbers of patients with tetralogy of Fallot (ToF) are increasing. However, long-term morbidity and need for reinterventions are concerns and also address issues of quality of life (QoL).

Methods: Patients with ToF and valid EuroQol-5 dimensions questionnaire (EQ-5D) were identified in the national Swedish register on congenital heart disease. Read More

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http://openheart.bmj.com/lookup/doi/10.1136/openhrt-2018-000
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http://dx.doi.org/10.1136/openhrt-2018-000932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443137PMC
February 2019
1 Read

CPHLN recommendations for the laboratory detection of Shiga toxin-producing (O157 and non-O157).

Can Commun Dis Rep 2018 Nov 1;44(11):304-307. Epub 2018 Nov 1.

National Microbiology Laboratory, MB & ON.

Shiga toxin-producing (STEC) are important enteric pathogens responsible for sporadic cases and outbreaks of gastroenteritis. O157:H7/NM (STEC O157) are the most commonly known STEC serotypes but it is now increasingly apparent that non-O157 STEC serotypes have been underreported in the past because they were not part of routine screening in many front-line laboratories. The Canadian Public Health Laboratory Network (CPHLN) has identified the need for improved detection and surveillance of non-O157 STEC and has developed the following recommendations to assist in the decision-making process for clinical and reference microbiology laboratories. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
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http://dx.doi.org/10.14745/ccdr.v44i11a06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449107PMC
November 2018
2 Reads

PRRs and NB-LRRs: From Signal Perception to Activation of Plant Innate Immunity.

Int J Mol Sci 2019 Apr 16;20(8). Epub 2019 Apr 16.

Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310027, China.

To ward off pathogens and pests, plants use a sophisticated immune system. They use pattern-recognition receptors (PRRs), as well as nucleotide-binding and leucine-rich repeat (NB-LRR) domains, for detecting nonindigenous molecular signatures from pathogens. Plant PRRs induce local and systemic immunity. Read More

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https://www.mdpi.com/1422-0067/20/8/1882
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http://dx.doi.org/10.3390/ijms20081882DOI Listing
April 2019
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Non-invasive Multi-modal Methods to Differentiate Inflamed vs Fibrotic Strictures in Patients With Crohn's Disease.

Clin Gastroenterol Hepatol 2019 Apr 14. Epub 2019 Apr 14.

IBD Centre, Humanitas Clinical and Research Centre, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy. Electronic address:

Fibrotic strictures occur in 30% of patients with Crohn's disease (CD). However, there are no therapeutic agents that prevent or reverse fibrotic strictures. Strictures are treated by endoscopic dilatation procedures and surgical procedures, but there are high rates of recurrence. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.025DOI Listing

Serological and molecular evidence of Bartonella henselae in cats from Luanda city, Angola.

Acta Trop 2019 Apr 14. Epub 2019 Apr 14.

Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Oporto, Portugal; EpiUnit, Epidemiology Research Unit, Institute of Public Health of the University of Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Oporto, Portugal. Electronic address:

A total of 100 domestic cats from Luanda (Angola) were tested for the presence of antibodies against Bartonella henselae and spotted fever group of Rickettsia (SFGR) using indirect immunofluorescence assay (IFA). Molecular screening targeting the riboflavin synthase (ribC) gene for Bartonella and outer membrane protein B (ompB) gene for Rickettsia, using conventional PCR and sequencing was also performed in cat´s blood samples. Sixty-six percent of the cats from Luanda had IgG antibodies against Bartonella species but none of them had antibodies against SFGR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183134
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http://dx.doi.org/10.1016/j.actatropica.2019.04.012DOI Listing
April 2019
2 Reads

CHM/REP1 Transcript Expression and Loss of Visual Function in Patients Affected by Choroideremia.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1547-1555

Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.

Purpose: To evaluate the disease progression in patients with clinical and genetic diagnoses of choroideremia during a long-term follow-up and to investigate the relationship between pathogenic variants in the CHM/REP1 gene and disease phenotypes.

Methods: We performed a retrospective longitudinal study on 51 affected men by reviewing medical charts at baseline and follow-up visits to extract the following ocular findings: best-corrected visual acuity, Goldmann visual field, optical coherence tomography, microperimetry. Data obtained from the analysis of DNA and mRNA were reevaluated for genetic classification of patients. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.18-25501DOI Listing
April 2019
1 Read

A computational solution to improve biomarker reproducibility during long-term projects.

PLoS One 2019 17;14(4):e0209060. Epub 2019 Apr 17.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America.

Biomarkers are fundamental to basic and clinical research outcomes by reporting host responses and providing insight into disease pathophysiology. Measuring biomarkers with research-use ELISA kits is universal, yet lack of kit standardization and unexpected lot-to-lot variability presents analytic challenges for long-term projects. During an ongoing two-year project measuring plasma biomarkers in cancer patients, control concentrations for one biomarker (PF) decreased significantly after changes in ELISA kit lots. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209060PLOS
April 2019
1 Read

The Diagnosis of Bronchopulmonary Dysplasia in Very Preterm Infants: An Evidence-Based Approach.

Am J Respir Crit Care Med 2019 Apr 17. Epub 2019 Apr 17.

Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Division of Neonatology, Philadelphia, Pennsylvania, United States.

Rationale: Current diagnostic criteria for bronchopulmonary dysplasia rely heavily on the level and duration of oxygen therapy, do not reflect contemporary neonatal care, nor adequately predict childhood morbidity.

Objective: To determine which of 18 pre-specified, revised definitions of bronchopulmonary dysplasia, that variably define disease presence and severity according to the level of respiratory support and supplemental oxygen administered at 36 weeks postmenstrual age, best predicts death or serious respiratory morbidity through 18-26 months corrected age.

Methods: We assessed infants born <32 weeks' gestation between 2011-2015 at 18 centers of the National Institute of Child Health and Human Development Neonatal Research Network. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201812-2348OC
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http://dx.doi.org/10.1164/rccm.201812-2348OCDOI Listing
April 2019
1 Read

Endoscopic Resections in Inflammatory Bowel Disease: A Multicentre European Outcomes Study.

J Crohns Colitis 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, Queen Alexandra Hospital, Southwick Hill Road, Portsmouth.

Background: Inflammatory bowel disease is associated with an increased risk of colorectal cancer, with estimates ranging from 2-18%, depending on the duration of colitis. The management of neoplasia in colitis remains controversial. Current guidelines recommend endoscopic resection if the lesion is clearly visible with distinct margins. Read More

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https://academic.oup.com/ecco-jcc/advance-article/doi/10.109
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http://dx.doi.org/10.1093/ecco-jcc/jjz075DOI Listing
April 2019
2 Reads

Scientific collaboration in Zika: identification of the leading research groups and researchers via social network analysis.

Cad Saude Publica 2019 Apr 8;35(3):e00220217. Epub 2019 Apr 8.

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.

The association between Zika and microcephaly drew international attention to Brazil. The emergency situation demanded speed and collective effort by researchers worldwide, and Science was quick to investigate the disease and publish the results. Scientific knowledge was created and disseminated through collaboration in this process. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0102-311X00220217DOI Listing
April 2019
2 Reads

Anesthesia-administered sedation for endoscopic retrograde cholangiopancreatography: monitored anesthesia care or general endotracheal anesthesia?

Curr Opin Anaesthesiol 2019 Apr 15. Epub 2019 Apr 15.

Division of Gastroenterology, Washington University School of Medicine, Saint Louis, Missouri, USA.

Purpose Of Review: The decision to undertake monitored anesthesia care (MAC) or general endotracheal anesthesia (GEA) for patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) is influenced by many factors. These include locoregional practice preferences, procedure complexity, patient position, and comorbidities. We aim to review the data regarding anesthesia-administered sedation for ERCP and identify the impact of airway management on procedure success, adverse event rates and endoscopy unit efficiency. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000741DOI Listing

Phasevarions of bacterial pathogens - phase-variable epigenetic regulators evolving from restriction-modification systems.

Microbiology 2019 Apr 17. Epub 2019 Apr 17.

1 Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia.

Phase-variable DNA methyltransferases control the expression of multiple genes via epigenetic mechanisms in a wide variety of bacterial species. These systems are called phasevarions, for phase-variable regulons. Phasevarions regulate genes involved in pathogenesis, host adaptation and antibiotic resistance. Read More

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http://dx.doi.org/10.1099/mic.0.000805DOI Listing

Inadequate diagnostics: the case to move beyond the bacilli for detection of meningitis due to Mycobacterium tuberculosis.

J Med Microbiol 2019 Apr 17. Epub 2019 Apr 17.

3 University of Minnesota, Minneapolis, MN, USA.

Tuberculosis (TB) meningitis is extremely difficult to diagnose due to its pauci-bacillary disease nature and new techniques are needed. Improved test sensitivity would allow for greater clinician confidence in diagnostic testing and has the potential to improve patient outcomes. Traditional microbiologic and molecular tests for TB meningitis focus on detection of TB bacilli and are inadequate. Read More

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http://dx.doi.org/10.1099/jmm.0.000975DOI Listing
April 2019
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Growth Kinetics of Kyasanur Forest Disease Virus in Mammalian Cell Lines and Development of Plaque Reduction Neutralization Test.

Vector Borne Zoonotic Dis 2019 Apr 17. Epub 2019 Apr 17.

ICMR-National Institute of Virology, Pune, India.

Kyasanur forest disease virus (KFDV) is a tick-borne flavivirus identified in 1957 in the Karnataka state of India causing fatalities in monkeys and humans. Even after the introduction of a vaccine in the endemic areas, hundreds of cases are reported every year. Being a high-risk category pathogen, the studies on this virus in India were limited till the past decade. Read More

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http://dx.doi.org/10.1089/vbz.2018.2405DOI Listing

Machine-learning identifies parkinson's disease patients based on resting-state between-network functional connectivity.

Br J Radiol 2019 Apr 17:20180886. Epub 2019 Apr 17.

1 Department of Diagnostic and Interventional Radiology, University Dusseldorf, Medical Faculty , Dusseldorf , Germany.

Objectives: Evaluation of a data-driven, model-based classification approach to discriminate idiopathic Parkinson's disease (PD) patients from healthy controls (HC) based on between-network connectivity in whole-brain resting-state functional MRI (rs-fMRI).

Methods: Whole-brain rs-fMRI (EPI/TR = 2.2  s/TE = 30  ms/flip angle = 90°/resolution = 3. Read More

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http://dx.doi.org/10.1259/bjr.20180886DOI Listing

Simply the Best: Anthropometric Indices for Predicting Cardiovascular Disease.

Authors:
Jie Eun Lee

Diabetes Metab J 2019 Apr;43(2):156-157

Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.

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https://synapse.koreamed.org/DOIx.php?id=10.4093/dmj.2019.00
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http://dx.doi.org/10.4093/dmj.2019.0057DOI Listing
April 2019
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Myocardial Blood Flow Quantified by Low-Dose Dynamic CT Myocardial Perfusion Imaging Is Associated with Peak Troponin Level and Impaired Left Ventricle Function in Patients with ST-Elevated Myocardial Infarction.

Korean J Radiol 2019 May;20(5):709-718

Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Objective: To investigate the association of myocardial blood flow (MBF) quantified by dynamic computed tomography (CT) myocardial perfusion imaging (MPI) with troponin level and left ventricle (LV) function in patients with ST-segment elevated myocardial infarction (STEMI).

Materials And Methods: Thirty-five STEMI patients who successfully had undergone reperfusion treatment within 1 week of their infarction were consecutively enrolled. All patients were referred for dynamic CT-MPI. Read More

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http://dx.doi.org/10.3348/kjr.2018.0729DOI Listing

Early clear cell "sugar" lung cancer management: A case report and a brief literature review.

Thorac Cancer 2019 Apr 16. Epub 2019 Apr 16.

UOC of Oncology, University of Rome, Aprilia, Italy.

A clear cell tumor is a histological entity that rarely originates outside of the kidney. We describe a rare case of a clear cell tumor of the lung, also known as "sugar cancer," that occurred in a 74 year-old male patient, and perform a brief literature review. This report highlights the importance of an adequate disease management team, including surgeons, oncologists, and pathologists, to identify the best therapeutic approach to improve survival rates and the quality of life of patients affected by this rare disease. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1759-7714.13
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http://dx.doi.org/10.1111/1759-7714.13077DOI Listing
April 2019
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Role of MRI in planning radical prostatectomy: what is the added value?

World J Urol 2019 Apr 15. Epub 2019 Apr 15.

University College London Hospital, NHS Foundation Trust, 47 Wimpole Street, Marylebone, London, W1G 8SE, UK.

Introduction: The goal of radical prostatectomy is to eradicate oncological disease while achieving the best possible functional outcomes. In this regard, nerve sparing offers a greater chance of recovering potency after surgery. Accurately locating prostate cancer foci is instrumental for identifying good candidates for this approach whilst maintaining safe oncological margins. Read More

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http://dx.doi.org/10.1007/s00345-019-02762-2DOI Listing

MetaMSD: meta analysis for mass spectrometry data.

PeerJ 2019 10;7:e6699. Epub 2019 Apr 10.

School of Community Health Sciences, University of Nevada - Reno, Reno, NV, United States of America.

Mass spectrometry-based proteomics facilitate disease understanding by providing protein abundance information about disease progression. For the same type of disease studies, multiple mass spectrometry datasets may be generated. Integrating multiple mass spectrometry datasets can provide valuable information that a single dataset analysis cannot provide. Read More

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https://peerj.com/articles/6699
Publisher Site
http://dx.doi.org/10.7717/peerj.6699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462182PMC
April 2019
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Quality and quantity control of gene expression by nonsense-mediated mRNA decay.

Nat Rev Mol Cell Biol 2019 Apr 16. Epub 2019 Apr 16.

Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.

Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most evolutionarily conserved cellular quality control mechanisms. Although NMD was first found to target one-third of mutated, disease-causing mRNAs, it is now known to also target ~10% of unmutated mammalian mRNAs to facilitate appropriate cellular responses - adaptation, differentiation or death - to environmental changes. Mutations in NMD genes in humans are associated with intellectual disability and cancer. Read More

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http://www.nature.com/articles/s41580-019-0126-2
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http://dx.doi.org/10.1038/s41580-019-0126-2DOI Listing
April 2019
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Complete assembly of the Leishmania donovani (HU3 strain) genome and transcriptome annotation.

Sci Rep 2019 Apr 16;9(1):6127. Epub 2019 Apr 16.

Centro de Biología Molecular "Severo Ochoa" (CSIC/UAM), Campus de Excelencia Internacional (CEI) UAM+CSIC, Universidad Autónoma de Madrid, Madrid, Spain.

Leishmania donovani is a unicellular parasite that causes visceral leishmaniasis, a fatal disease in humans. In this study, a complete assembly of the genome of L. donovani is provided. Read More

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http://dx.doi.org/10.1038/s41598-019-42511-4DOI Listing