876 results match your criteria Beriberi Thiamine Deficiency

Beriberi in Brazil: A Disease That Affects Indigenous People.

Food Nutr Bull 2021 Jun 1:3795721211002057. Epub 2021 Jun 1.

Postgraduate Program in Collective Health, Federal University of Maranhão, São Luís, Maranhão, Brazil.

Background: Beriberi is the clinical manifestation of thiamine deficiency. It is multicausal and typically associated with poverty and food insecurity among vulnerable populations, such as indigenous people.

Objective: The objective of this study was to carry out a spatial analysis of reported cases of beriberi among indigenous people in Brazil. Read More

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A fresh look at thiamine deficiency-new analyses by the global thiamine alliance.

Ann N Y Acad Sci 2021 May 3. Epub 2021 May 3.

Department of Nutrition, University of California Davis, Davis, California.

Severe thiamine (vitamin B ) deficiency is generally regarded as a problem affecting mostly infants in low-income communities of Southeast Asia and adult alcoholics regardless of their location. However, recent scholarship shows that the disorders associated with thiamine deficiency may also affect heretofore unsuspected populations, and that the scope of disorders, including some long-lasting neurocognitive consequences, is broader than previously thought. Read More

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A Retrospective Case Series of Thiamine Deficiency in Non-Alcoholic Hospitalized Veterans: An Important Cause of Delirium and Falling?

J Clin Med 2021 Apr 1;10(7). Epub 2021 Apr 1.

Medicine Department, Veterans Affairs Sierra Nevada Healthcare System, Reno, NV 89502, USA.

Thiamine deficiency (TD) in non-alcoholic hospitalized patients causes a variety of non-specific symptoms. Studies suggest it is not rare in acutely and chronically ill individuals in high income countries and is underdiagnosed. Our aim is to demonstrate data which help define the risk factors and constellation of symptoms of TD in this population. Read More

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The signs and symptoms of Ernest Shackleton.

J Med Biogr 2021 Apr 24:9677720211002205. Epub 2021 Apr 24.

Department of Anesthesia, Critical Care and Pain Medicine, 2348Massachusetts General Hospital, Boston, MA, USA.

Ernest Shackleton, an accomplished Antarctic explorer, developed a life-threatening illness during the Discovery Antarctic expedition of 1901-4. His documented signs and symptoms included inflamed gums attributed to scurvy, severe dyspnea, and exercise intolerance, presenting in a setting of nutritional deficiency. Physical examinations at a later date, also following a prolonged diet of limited fresh food, revealed a pulmonary systolic murmur. Read More

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Shoshin beriberi.

Tidsskr Nor Laegeforen 2021 04 19;141(6). Epub 2021 Apr 19.

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Case Report: Fulminant Infantile Beriberi: A Report of Six Cases.

Am J Trop Med Hyg 2021 Apr 19. Epub 2021 Apr 19.

Thiamine deficiency disorders are an under-recognized public health problem in low- and middle-income countries. Infantile beriberi, the most important symptom for children, is suspected to significantly contribute to infant mortality and lifelong neurodevelopmental morbidity. Lack of awareness, varied clinical presentation, and lack of a readily available diagnostic marker lead to frequent misdiagnoses. Read More

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J Emerg Med 2021 Apr 6. Epub 2021 Apr 6.

Department of Emergency Medicine, University of California, San Diego, San Diego, California; Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, San Diego, California.

Background: Thiamine deficiency is an uncommon cause of severe illness in the United States that can lead to significant morbidity because of high-output cardiac failure, peripheral neuropathy, and permanent neurologic impairment. We report the case of a middle-aged woman with extreme malnutrition caused by complications of Roux-en-Y gastric bypass (RYGB) surgery who presented with signs and symptoms of severe thiamine deficiency and septic shock.

Case Report: A 43-year-old woman who had undergone RYGB surgery and who had multiple complications presented to the emergency department with agitation, confusion, and lethargy. Read More

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Infantile thiamine deficiency in South and Southeast Asia: An age-old problem needing new solutions.

T J Smith S Y Hess

Nutr Bull 2021 Mar 11;46(1):12-25. Epub 2021 Jan 11.

Institute for Global Nutrition University of California Davis Davis CA USA.

Infantile beriberi, a potentially fatal disorder caused by thiamine deficiency, is often viewed as a disease confined to history in regions of the world with predominant white rice consumption. Recent case reports have, however, highlighted the persistence of thiamine deficiency as a cause of infant mortality in South and Southeast Asia. Low infant thiamine status and incidence of beriberi is attributable to maternal thiamine deficiency and insufficient breast milk thiamine. Read More

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Case of hypoactive delirium precipitated by thiamine deficiency.

BMJ Case Rep 2021 Mar 17;14(3). Epub 2021 Mar 17.

MetroHealth Medical Center, Hospital Medicnie, Case Western Reserve University, Cleveland, Ohio, USA

Thiamine is an essential cofactor in the process of nucleic acid synthesis. Neuronal tissues are especially sensitive to thiamine deficiency, manifesting as Wernicke's encephalopathy (WE). The typical triad of WE, encephalopathy, oculomotor dysfunction and gait ataxia, is only present in less than one-third of the cases. Read More

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Wernicke's encephalopathy post hyperemesis gravidarum misdiagnosed as Guillain-Barre syndrome: lessons for the frontline.

BMJ Case Rep 2021 Mar 16;14(3). Epub 2021 Mar 16.

Medicine, Kasturba Medical College Mangalore, Mangalore, India.

We report a case of a 26-year-old pregnant woman, who presented with subacute limb weakness. This was initially suspected to be Guillain-Barre syndrome but subsequently found to be the motor neuropathy of dry beriberi (vitamin B1, thiamine deficiency) along with associated Wernicke's encephalopathy (WE). The underlying cause was revealed as hyperemesis gravidarum (HG). Read More

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A hemodialysis patient with difficulty ambulating: Answers.

Pediatr Nephrol 2021 Jul 20;36(7):2071-2073. Epub 2021 Jan 20.

Division of Nephrology, Boston Children's Hospital, 300 Longwood Ave, HU-319, Boston, MA, 02115, USA.

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Infantile thiamine deficiency: Redefining the clinical patterns.

Nutrition 2021 04 29;84:111097. Epub 2020 Nov 29.

Department of Pediatrics, GB Pant Hospital, Government Medical College, Srinagar, Jammu and Kashmir, India.

Objectives: Thiamine deficiency (TD) is frequently suspected and treated at our hospital. In our retrospective study, we aimed at finding the clinical and laboratory spectrum of infantile TD presenting to a single center over a period of time.

Methods: The diagnosis was made on criterion standard of response to thiamine challenge. Read More

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Wernicke's encephalopathy - from basic science to clinical practice. Part 1: Understanding the role of thiamine.

Ther Adv Psychopharmacol 2020 29;10:2045125320978106. Epub 2020 Dec 29.

Department of Clinical Sciences, Division of Psychiatry, Sunderby Research Unit, Umeå University, Umeå, Sweden.

Wernicke's encephalopathy (WE) is an acute neuropsychiatric state. Untreated, WE can lead to coma or death, or progress to Korsakoff syndrome (KS) - a dementia characterized by irreversible loss of anterograde memory. Thiamine (vitamin B1) deficiency lies at the heart of this condition. Read More

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December 2020

Modeling thiamine fortification: a case study from Kuria atoll, Republic of Kiribati.

Ann N Y Acad Sci 2021 Jan 12. Epub 2021 Jan 12.

Department of Human Nutrition, University of Otago, Dunedin, New Zealand.

In 2014, there was an outbreak of beriberi on Kuria, a remote atoll in Kiribati, a small Pacific Island nation. A thiamine-poor diet consisting mainly of rice, sugar, and small amounts of fortified flour was likely to blame. We aimed to design a food fortification strategy to improve thiamine intakes in Kuria. Read More

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January 2021

Assessment of salt intake to consider salt as a fortification vehicle for thiamine in Cambodia.

Ann N Y Acad Sci 2021 Jan 7. Epub 2021 Jan 7.

Department of Applied Human Nutrition, Mount Saint Vincent University, Halifax, Nova Scotia, Canada.

Thiamine deficiency is a public health issue in Cambodia. Thiamine fortification of salt has been proposed; however, the salt intake of lactating women, the target population, is currently unknown. We estimated salt intakes among lactating women (<6 months postpartum) using three methods: repeat observed-weighed intake records and 24-h urinary sodium excretions (n = 104), and household salt disappearance (n = 331). Read More

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January 2021

The rediscovery of thiamine deficiency disorders at a secondary level mission hospital in Northeast India.

Ann N Y Acad Sci 2020 Dec 31. Epub 2020 Dec 31.

Department of Obstetrics and Gynecology, Makunda Christian Leprosy and General Hospital, Assam, India.

In this article, we report the different presentations of thiamine deficiency disorders seen at a remote rural mission hospital in Northeast India, including investigations, treatment, and recovery. Two case studies, one of an infant with cardiac beriberi and the other of a nonalcoholic adult presenting with peripheral neuropathy, cardiomyopathy, and metabolic acidosis and responding to thiamine supplementation, are described in detail. We share our experience with these clinical entities over the past two decades, including recent research and lessons learned, and suggest ways forward to identify at-risk populations in Northeast India, improve early diagnosis and treatment, and promote preventive public health strategies. Read More

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December 2020

Erythrocyte transketolase activity coefficient (ETKAC) assay protocol for the assessment of thiamine status.

Ann N Y Acad Sci 2020 Dec 22. Epub 2020 Dec 22.

NIHR BRC Nutritional Biomarker Laboratory, MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Vitamin B1 (thiamine) is an essential nutrient that acts as a cofactor for a number of metabolic processes, particularly in energy metabolism. Symptoms of classic thiamine deficiency are recognized as beriberi, although clinical symptoms are nonspecific and recognition of subclinical deficiency is difficult. Therefore, reliable biomarkers of thiamine status are required. Read More

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December 2020

Thiamine deficiency disorders: a clinical perspective.

Ann N Y Acad Sci 2020 Dec 10. Epub 2020 Dec 10.

Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.

Thiamine is an essential water-soluble vitamin that plays an important role in energy metabolism. Thiamine deficiency presents many challenges to clinicians, in part due to the broad clinical spectrum, referred to as thiamine deficiency disorders (TDDs), affecting the metabolic, neurologic, cardiovascular, respiratory, gastrointestinal, and musculoskeletal systems. Concurrent illnesses and overlapping signs and symptoms with other disorders can further complicate this. Read More

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December 2020

Thiamine Deficiency as a Cause for Acute Circulatory Failure: An Overlooked Association in Western Countries.

CJC Open 2020 Nov 19;2(6):716-718. Epub 2020 Jul 19.

Cardiac Intensive Care Unit, Louis Pradel Hospital, Bron, France.

A 42 year-old patient presented with circulatory failure and lactic acidosis. Clinical features, later coupled with biological tests, led to the diagnosis of wet beriberi syndrome and scurvy. Echocardiography showed a pattern of thiamine deficiency with high cardiac output and low vascular resistance. Read More

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November 2020

Dry Beriberi Manifesting as Acute Inflammatory Demyelinating Polyneuropathy in a Patient With Decompensated Alcohol-Induced Cirrhosis.

Cureus 2020 Oct 31;12(10):e11281. Epub 2020 Oct 31.

Gastroenterology and Hepatology, University of Nebraska Medical Center, Omaha, USA.

Thiamine (vitamin B1) deficiency is uncommon in developed countries and is most commonly seen in patients with poor dietary intake, malabsorption syndromes, and alcoholism. With the increasing rates of alcohol use, thiamine deficiency is likely an under-recognized and potentially reversible cause of sensorimotor dysfunction called dry beriberi. We present a case of profound lower extremity weakness in a 28-year-old female from Nepal with decompensated alcohol-induced cirrhosis. Read More

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October 2020

Thiamine-Responsive Acute Pulmonary Hypertension of Early Infancy (TRAPHEI)-A Case Series and Clinical Review.

Children (Basel) 2020 Oct 28;7(11). Epub 2020 Oct 28.

Department of Pediatrics, UC Davis Children's Hospital, Sacramento, CA 95817, USA.

Persistent pulmonary hypertension of the newborn (PPHN) is a syndrome of high pulmonary vascular resistance (PVR) commonly seen all over the world in the immediate newborn period. Several case reports from India have recently described severe pulmonary hypertension among infants in the postneonatal period. These cases typically present with respiratory distress in 1-6-month-old infants, breastfed by mothers on a polished rice-based diet. Read More

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October 2020

Investigating oxythiamine levels in children undergoing kidney transplantation and the risk of immediate post-operative metabolic and hemodynamic decompensation.

Pediatr Nephrol 2021 Apr 16;36(4):987-993. Epub 2020 Oct 16.

University of British Columbia (Pediatrics), Vancouver, British Columbia, Canada.

Background: Oxythiamine is a uremic toxin that acts as an antimetabolite to thiamine and has been associated with cases of Shoshin beriberi syndrome in adults. We sought to identify whether surgical stress and ischemia/reperfusion injury may precipitate functional thiamine deficiency in children peritransplant.

Methods: We retrospectively analyzed a cohort of pediatric kidney transplant recipients. Read More

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Comparison of Thiamin Diphosphate High-Performance Liquid Chromatography and Erythrocyte Transketolase Assays for Evaluating Thiamin Status in Malaria Patients without Beriberi.

Am J Trop Med Hyg 2020 12 24;103(6):2600-2604. Epub 2020 Sep 24.

Lao Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.

Thiamin deficiency, or beriberi, is an increasingly re-recognized cause of morbidity and mortality in the developing world. Thiamin status has traditionally been measured through the erythrocyte activation assay (ETKA) or basal transketolase activity (ETK), which indirectly measure thiamin diphosphate (TDP). Thiamin diphosphate can also be measured directly by high-performance liquid chromatography (HPLC), which may allow a more precise estimation of thiamin status. Read More

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December 2020

The Relevance of Thiamine Evaluation in a Practical Setting.

Nutrients 2020 Sep 13;12(9). Epub 2020 Sep 13.

Lombardy Regional Course for General Practitioner, PoliS-Lombardia, Via Taramelli 12/F, 20100 Milano, Italy.

Thiamine is a crucial cofactor involved in the maintenance of carbohydrate metabolism and participates in multiple cellular metabolic processes. Although thiamine can be obtained from various food sources, some common food groups are deficient in thiamine, and it can be denatured by high temperature and pH. Additionally, different drugs can alter thiamine metabolism. Read More

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September 2020

Acute respiratory failure in an infant and thiamine deficiency in West Africa: a case report.

Oxf Med Case Reports 2020 Jun 25;2020(6):omaa041. Epub 2020 Jun 25.

Médecins Sans Frontières Spain, Dakar office, Senegal.

In paediatrics, the overall clinical picture of thiamine deficiency (TD) is not easy to recognize, because it mimics or can be confused with other diseases even in cases of classic beriberi. Unsurprisingly, the likelihood of misdiagnosis of TD is even greater where beriberi has not been described. Critically ill patients have increased thiamine body consumption and dextrose-based IV fluid increases thiamine cellular demand even further. Read More

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Pathophysiology, prevention, and treatment of beriberi after gastric surgery.

Nutr Rev 2020 12;78(12):1015-1029

Upper Gastrointestinal Surgery Department, University of New South Wales, Liverpool Public Hospital, Liverpool, Sydney, New South Wales, Australia, and the Sydney Institute for Obesity Surgery, Ashfield, Sydney, New South Wales, Australia.

Beriberi is a nutritional complication of gastric surgery, caused by deficiency of vitamin B1, or thiamine. Thiamine deficiency leads to impaired glucose metabolism, decreased delivery of oxygen by red blood cells, cardiac dysfunction, failure of neurotransmission, and neuronal death. This review describes the history and pathophysiology of beriberi as well as the relationship between beriberi and nutritional deficiencies after gastric surgery. Read More

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December 2020

Shoshin beriberi in a patient with oral and cutaneous graft-versus-host disease.

JAAD Case Rep 2020 May 29;6(5):420-421. Epub 2020 Apr 29.

Department of Dermatology, Stanford University School of Medicine, Stanford, California.

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Non-alcoholic beriberi, Wernicke encephalopathy and long-term eating disorder: case report and a mini-review.

Eat Weight Disord 2021 Mar 4;26(2):729-732. Epub 2020 Mar 4.

Neurology Unit, "A. Manzoni" Hospital-ASST Lecco, Via dell'Eremo 9/11, 23900, Lecco, Italy.

Introduction: Nowadays, reports of beriberi are rare in developed countries. Wernicke encephalopathy may be present in about 25% of patients with beriberi.

Case Report: We report the case of a woman with history of depression and chronic eating disorder, who complained Wernicke encephalopathy and beriberi. Read More

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Gastrointestinal Beriberi Mimicking a Surgical Emergency in a Well-Nourished Patient: A Case Report.

Mayo Clin Proc Innov Qual Outcomes 2019 Dec 2;3(4):506-509. Epub 2019 Nov 2.

Division of Trauma, Critical Care, and General Surgery, Mayo Clinic, Rochester, MN.

Beriberi is a well-documented disease caused by thiamine deficiency. The diagnosis of gastrointestinal beriberi in the clinical setting is uncommon, especially in nonalcoholic patients. Failure to recognize beriberi can result in devastating acute multisystem organ failure; however, timely treatment can result in rapid improvement in a patient's clinical status. Read More

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December 2019

Development and Characterization of Monoclonal Antibodies for the Mycotoxin Citreoviridin.

Toxins (Basel) 2019 10 30;11(11). Epub 2019 Oct 30.

Department of Food and Life Science, Graduate School of Life and Environmental Sciences, Azabu University, Sagamihara, Kanagawa 252-5201, Japan.

Citreoviridin (CTV) in an inhibitor of mitochondrial ATPase that has been isolated from molded yellow rice and linked to the human disease Shoshin-kakke (acute cardiac beriberi). The disease results from a deficiency of thiamine, however, purified CTV can reproduce the symptoms in experimental animals. The link between CTV and Shoshin-kakke has been difficult to resolve, in part because cases of the disease are rare. Read More

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October 2019