893 results match your criteria Beriberi Thiamine Deficiency

Critical vitamin deficiencies in autism spectrum disorder: Reversible and irreversible outcomes.

Eur J Clin Nutr 2022 Jun 10. Epub 2022 Jun 10.

Department of Pediatrics, Kyushu University Hospital, Fukuoka, 812-8582, Japan.

Vitamin deficiencies are an emerging concern in the management of children with autism spectrum disorder (ASD). Particular attention is required for recognizing the variable signs caused by unbalanced food intakes. We herein report two patients with multiple vitamin deficiencies who needed critical care showing different prognoses. Read More

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A Case of Pulmonary Hypertension in a 67-Year-Old Woman with Thiamine Deficiency Following Partial Gastrectomy and Exacerbated by Diuretics.

Am J Case Rep 2022 Mar 17;23:e935308. Epub 2022 Mar 17.

Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.

BACKGROUND Thiamine deficiency often occurs in patients with alcohol abuse and unbalanced diets. However, gastric surgery and/or use of diuretics can also cause this situation. Importantly, thiamine deficiency can cause pulmonary hypertension, which is completely reversible. Read More

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Beriberi Neuropathy Mimicking Guillian-Barre Syndrome in a Teenager With Food Restriction: A Case Report.

Cureus 2022 Jan 19;14(1):e21417. Epub 2022 Jan 19.

Child Neurology and Neurodevelopmental Disabilities, West Virginia University Medicine, Morgantown, USA.

Beriberi neuropathy (thiamine deficiency) and Guillian-Barre Syndrome (GBS) both can present with areflexia and progressive ascending weakness. A physical examination can be equivocal between the two. In cases where GBS is suspected clinically but initial work-up with cerebral spinal fluid (CSF) studies and magnetic resonance imaging (MRI) of the spine are not diagnostic, nerve conduction study/electromyography (NCS/EMG) should be done to evaluate beriberi neuropathy. Read More

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January 2022

[Wernicke-Korsakoff syndrome and other diseases associated with thyamine deficiency].

Med Clin (Barc) 2022 05 14;158(9):431-436. Epub 2022 Jan 14.

Servicio de Medicina Interna, Hospital Universitario de Salamanca-IBSAL, Universidad de Salamanca, Salamanca, España. Electronic address:

Wernicke-Korsakoff syndrome is the best known consequence of thiamine deficiency, frequently associated with patients with chronic and excessive alcohol consumption, but it can be produced by any cause that produces thiamine deficiency. The disease is underdiagnosed so it is essential to have a high clinical suspicion, mainly in patients who do not have alcohol consumption as a risk factor. For this, the diagnosis continues to be eminently clinical, with the difficulty of high clinical variability. Read More

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Thiamine-responsive, life-threatening, pulmonary hypertensive crisis with encephalopathy in young infants: A case series.

Eur J Paediatr Neurol 2022 Jan 17;36:93-98. Epub 2021 Dec 17.

Department of Pediatric Neurology, Rainbow Children's Hospital, Secunderabad, Telangana, India. Electronic address:

Objective: Thiamine (Vitamin B1) deficiency (TD), although reduced in incidence, is still seen in infants. We describe a rarely reported form of infantile TD with life-threatening pulmonary hypertensive crisis and severe encephalopathy, with dramatic response to thiamine supplementation.

Methods: Study design: Descriptive case series. Read More

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January 2022

Wet beriberi and scurvy.

Intern Med J 2021 Dec;51(12):2146-2148

Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia.

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December 2021

A case series of rare neurological and cardio-pulmonary manifestations of thiamine deficiency in pregnancy and lactation.

Obstet Med 2021 Dec 13;14(4):263-268. Epub 2020 Oct 13.

Department of Radiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

Thiamine (vitamin B1) is a sulfur-containing, water-soluble vitamin that plays an essential role in energy metabolism and the tricarboxylic acid cycle. There is an increased need for vitamin B1 (1-1.2 mg daily) during pregnancy and lactation. Read More

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December 2021

Lessons of the month 1: Shoshin beriberi: A case report of fulminant cardiovascular collapse, intractable hyperlactatemia and deteriorating consciousness.

Clin Med (Lond) 2021 11;21(6):e670-e672

Colchester General Hospital, Colchester, UK.

Shoshin beriberi is a fulminant variant of thiamine deficiency, often presenting with severe lactic acidosis and cardiogenic shock. Due to the sparsity of this condition, delays in diagnosis can lead to fatality. However, rapid reversal of symptoms can be easily achieved through intravenous thiamine replacement. Read More

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November 2021

Thiamine deficiency in Gambian women of reproductive age.

Ann N Y Acad Sci 2022 01 20;1507(1):162-170. Epub 2021 Sep 20.

MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, The Gambia.

Thiamine deficiency disorders are associated with a variety of clinical symptoms affecting the nervous and cardiovascular systems. There is growing recognition that thiamine deficiency can occur in populations well beyond the classical region of South Asia, and at-risk populations include those who receive a large proportion of their energy from polished white rice (or other low-thiamine staple foods) and with low dietary diversity. Reports of thiamine deficiency in West Africa over the last century have suggested that this has historically been an issue in this population, but in more recent decades, these reports have been limited to prison populations. Read More

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January 2022

A case of dry beriberi from alcohol use disorder and disordered eating.

Subst Abus 2022 3;43(1):204-205. Epub 2021 Aug 3.

Wexner Medical Center, The Ohio State University, Columbus, OH, USA.

Thiamin is an essential vitamin that is involved in every organ system in the body. Thiamin deficiency can present as beriberi or Wernicke's encephalopathy. We seek to educate practitioners in developed countries to include beriberi on the differential diagnosis when a patient with alcohol use disorder, poor diet and/or disordered eating presents with ascending paralysis without albuminocytologic dissociation. Read More

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Pediatric thiamine deficiency disorders in high-income countries between 2000 and 2020: a clinical reappraisal.

Ann N Y Acad Sci 2021 08 26;1498(1):57-76. Epub 2021 Jul 26.

The New York Academy of Sciences, New York, New York.

Often thought to be a nutritional issue limited to low- and middle-income countries (LMICs), pediatric thiamine deficiency (PTD) is perceived as being eradicated or anecdotal in high-income countries (HICs). In HICs, classic beriberi cases in breastfed infants by thiamine-deficient mothers living in disadvantaged socioeconomic conditions are thought to be rare. This study aims to assess PTD in HICs in the 21st century. Read More

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Wide pulse pressure and Quincke's pulse in high-output heart failure.

BMJ Case Rep 2021 Jul 22;14(7). Epub 2021 Jul 22.

Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA

A 74-year-old man with a history of chronic alcohol use presented with progressive exertional dyspnoea and weight gain. On physical examination, he was noted to have wide pulse pressure, elevated jugular venous pressure, and alternating flushing and blanching of the nail beds in concert with the cardiac cycle, known as Quincke's pulse. Transthoracic echocardiography demonstrated normal biventricular systolic function and valvular function, but noted a dilated inferior vena cava. Read More

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The conundrum of Thiamine Responsive Acute Pulmonary Hypertension (TRAPH) syndrome in the Emergency Department.

Am J Emerg Med 2021 Nov 7;49:185-188. Epub 2021 Jun 7.

Department of Emergency Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India. Electronic address:

Background: Management of acute pulmonary hypertension in the Emergency Department(ED) can be challenging. The treatment is specialised, requires rapid identification and correction of the precipitating cause; failing which the patient enters a vortex of deterioration. We describe a lesser-known cause for the same, Thiamine responsive acute pulmonary hypertension (TRAPH) syndrome where timely appropriate treatment can result in dramatic improvement. Read More

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November 2021

Beriberi in Brazil: A Disease That Affects Indigenous People.

Food Nutr Bull 2021 09 1;42(3):427-436. Epub 2021 Jun 1.

Postgraduate Program in Collective Health, 37892Federal University of Maranhão, São Luís, Maranhão, Brazil.

Background: Beriberi is the clinical manifestation of thiamine deficiency. It is multicausal and typically associated with poverty and food insecurity among vulnerable populations, such as indigenous people.

Objective: The objective of this study was to carry out a spatial analysis of reported cases of beriberi among indigenous people in Brazil. Read More

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September 2021

A fresh look at thiamine deficiency-new analyses by the global thiamine alliance.

Ann N Y Acad Sci 2021 08 3;1498(1):5-8. Epub 2021 May 3.

Department of Nutrition, University of California Davis, Davis, California.

Severe thiamine (vitamin B ) deficiency is generally regarded as a problem affecting mostly infants in low-income communities of Southeast Asia and adult alcoholics regardless of their location. However, recent scholarship shows that the disorders associated with thiamine deficiency may also affect heretofore unsuspected populations, and that the scope of disorders, including some long-lasting neurocognitive consequences, is broader than previously thought. Read More

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A Retrospective Case Series of Thiamine Deficiency in Non-Alcoholic Hospitalized Veterans: An Important Cause of Delirium and Falling?

J Clin Med 2021 Apr 1;10(7). Epub 2021 Apr 1.

Medicine Department, Veterans Affairs Sierra Nevada Healthcare System, Reno, NV 89502, USA.

Thiamine deficiency (TD) in non-alcoholic hospitalized patients causes a variety of non-specific symptoms. Studies suggest it is not rare in acutely and chronically ill individuals in high income countries and is underdiagnosed. Our aim is to demonstrate data which help define the risk factors and constellation of symptoms of TD in this population. Read More

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The signs and symptoms of Ernest Shackleton.

J Med Biogr 2021 Apr 24:9677720211002205. Epub 2021 Apr 24.

Department of Anesthesia, Critical Care and Pain Medicine, 2348Massachusetts General Hospital, Boston, MA, USA.

Ernest Shackleton, an accomplished Antarctic explorer, developed a life-threatening illness during the Discovery Antarctic expedition of 1901-4. His documented signs and symptoms included inflamed gums attributed to scurvy, severe dyspnea, and exercise intolerance, presenting in a setting of nutritional deficiency. Physical examinations at a later date, also following a prolonged diet of limited fresh food, revealed a pulmonary systolic murmur. Read More

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Shoshin beriberi.

Tidsskr Nor Laegeforen 2021 04 19;141(6). Epub 2021 Apr 19.

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Case Report: Fulminant Infantile Beriberi: A Report of Six Cases.

Am J Trop Med Hyg 2021 04 19;104(6):2238-2240. Epub 2021 Apr 19.

Thiamine deficiency disorders are an under-recognized public health problem in low- and middle-income countries. Infantile beriberi, the most important symptom for children, is suspected to significantly contribute to infant mortality and lifelong neurodevelopmental morbidity. Lack of awareness, varied clinical presentation, and lack of a readily available diagnostic marker lead to frequent misdiagnoses. Read More

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J Emerg Med 2021 09 6;61(3):314-319. Epub 2021 Apr 6.

Department of Emergency Medicine, University of California, San Diego, San Diego, California; Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, San Diego, California.

Background: Thiamine deficiency is an uncommon cause of severe illness in the United States that can lead to significant morbidity because of high-output cardiac failure, peripheral neuropathy, and permanent neurologic impairment. We report the case of a middle-aged woman with extreme malnutrition caused by complications of Roux-en-Y gastric bypass (RYGB) surgery who presented with signs and symptoms of severe thiamine deficiency and septic shock.

Case Report: A 43-year-old woman who had undergone RYGB surgery and who had multiple complications presented to the emergency department with agitation, confusion, and lethargy. Read More

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September 2021

Infantile thiamine deficiency in South and Southeast Asia: An age-old problem needing new solutions.

T J Smith S Y Hess

Nutr Bull 2021 Mar 11;46(1):12-25. Epub 2021 Jan 11.

Institute for Global Nutrition University of California Davis Davis CA USA.

Infantile beriberi, a potentially fatal disorder caused by thiamine deficiency, is often viewed as a disease confined to history in regions of the world with predominant white rice consumption. Recent case reports have, however, highlighted the persistence of thiamine deficiency as a cause of infant mortality in South and Southeast Asia. Low infant thiamine status and incidence of beriberi is attributable to maternal thiamine deficiency and insufficient breast milk thiamine. Read More

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Case of hypoactive delirium precipitated by thiamine deficiency.

BMJ Case Rep 2021 Mar 17;14(3). Epub 2021 Mar 17.

MetroHealth Medical Center, Hospital Medicnie, Case Western Reserve University, Cleveland, Ohio, USA

Thiamine is an essential cofactor in the process of nucleic acid synthesis. Neuronal tissues are especially sensitive to thiamine deficiency, manifesting as Wernicke's encephalopathy (WE). The typical triad of WE, encephalopathy, oculomotor dysfunction and gait ataxia, is only present in less than one-third of the cases. Read More

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Wernicke's encephalopathy post hyperemesis gravidarum misdiagnosed as Guillain-Barre syndrome: lessons for the frontline.

BMJ Case Rep 2021 Mar 16;14(3). Epub 2021 Mar 16.

Medicine, Kasturba Medical College Mangalore, Mangalore, India.

We report a case of a 26-year-old pregnant woman, who presented with subacute limb weakness. This was initially suspected to be Guillain-Barre syndrome but subsequently found to be the motor neuropathy of dry beriberi (vitamin B1, thiamine deficiency) along with associated Wernicke's encephalopathy (WE). The underlying cause was revealed as hyperemesis gravidarum (HG). Read More

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A hemodialysis patient with difficulty ambulating: Answers.

Pediatr Nephrol 2021 Jul 20;36(7):2071-2073. Epub 2021 Jan 20.

Division of Nephrology, Boston Children's Hospital, 300 Longwood Ave, HU-319, Boston, MA, 02115, USA.

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Infantile thiamine deficiency: Redefining the clinical patterns.

Nutrition 2021 04 29;84:111097. Epub 2020 Nov 29.

Department of Pediatrics, GB Pant Hospital, Government Medical College, Srinagar, Jammu and Kashmir, India.

Objectives: Thiamine deficiency (TD) is frequently suspected and treated at our hospital. In our retrospective study, we aimed at finding the clinical and laboratory spectrum of infantile TD presenting to a single center over a period of time.

Methods: The diagnosis was made on criterion standard of response to thiamine challenge. Read More

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Wernicke's encephalopathy - from basic science to clinical practice. Part 1: Understanding the role of thiamine.

Ther Adv Psychopharmacol 2020 29;10:2045125320978106. Epub 2020 Dec 29.

Department of Clinical Sciences, Division of Psychiatry, Sunderby Research Unit, Umeå University, Umeå, Sweden.

Wernicke's encephalopathy (WE) is an acute neuropsychiatric state. Untreated, WE can lead to coma or death, or progress to Korsakoff syndrome (KS) - a dementia characterized by irreversible loss of anterograde memory. Thiamine (vitamin B1) deficiency lies at the heart of this condition. Read More

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December 2020

Modeling thiamine fortification: a case study from Kuria atoll, Republic of Kiribati.

Ann N Y Acad Sci 2021 08 12;1498(1):108-115. Epub 2021 Jan 12.

Department of Human Nutrition, University of Otago, Dunedin, New Zealand.

In 2014, there was an outbreak of beriberi on Kuria, a remote atoll in Kiribati, a small Pacific Island nation. A thiamine-poor diet consisting mainly of rice, sugar, and small amounts of fortified flour was likely to blame. We aimed to design a food fortification strategy to improve thiamine intakes in Kuria. Read More

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Assessment of salt intake to consider salt as a fortification vehicle for thiamine in Cambodia.

Ann N Y Acad Sci 2021 08 7;1498(1):85-95. Epub 2021 Jan 7.

Department of Applied Human Nutrition, Mount Saint Vincent University, Halifax, Nova Scotia, Canada.

Thiamine deficiency is a public health issue in Cambodia. Thiamine fortification of salt has been proposed; however, the salt intake of lactating women, the target population, is currently unknown. We estimated salt intakes among lactating women (<6 months postpartum) using three methods: repeat observed-weighed intake records and 24-h urinary sodium excretions (n = 104), and household salt disappearance (n = 331). Read More

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The rediscovery of thiamine deficiency disorders at a secondary level mission hospital in Northeast India.

Ann N Y Acad Sci 2021 08 31;1498(1):96-107. Epub 2020 Dec 31.

Department of Obstetrics and Gynecology, Makunda Christian Leprosy and General Hospital, Assam, India.

In this article, we report the different presentations of thiamine deficiency disorders seen at a remote rural mission hospital in Northeast India, including investigations, treatment, and recovery. Two case studies, one of an infant with cardiac beriberi and the other of a nonalcoholic adult presenting with peripheral neuropathy, cardiomyopathy, and metabolic acidosis and responding to thiamine supplementation, are described in detail. We share our experience with these clinical entities over the past two decades, including recent research and lessons learned, and suggest ways forward to identify at-risk populations in Northeast India, improve early diagnosis and treatment, and promote preventive public health strategies. Read More

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Erythrocyte transketolase activity coefficient (ETKAC) assay protocol for the assessment of thiamine status.

Ann N Y Acad Sci 2021 08 22;1498(1):77-84. Epub 2020 Dec 22.

NIHR BRC Nutritional Biomarker Laboratory, MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Vitamin B1 (thiamine) is an essential nutrient that acts as a cofactor for a number of metabolic processes, particularly in energy metabolism. Symptoms of classic thiamine deficiency are recognized as beriberi, although clinical symptoms are nonspecific and recognition of subclinical deficiency is difficult. Therefore, reliable biomarkers of thiamine status are required. Read More

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