852 results match your criteria Beriberi Thiamine Deficiency


Acute respiratory failure in an infant and thiamine deficiency in West Africa: a case report.

Oxf Med Case Reports 2020 Jun 25;2020(6):omaa041. Epub 2020 Jun 25.

Médecins Sans Frontières Spain, Dakar office, Senegal.

In paediatrics, the overall clinical picture of thiamine deficiency (TD) is not easy to recognize, because it mimics or can be confused with other diseases even in cases of classic beriberi. Unsurprisingly, the likelihood of misdiagnosis of TD is even greater where beriberi has not been described. Critically ill patients have increased thiamine body consumption and dextrose-based IV fluid increases thiamine cellular demand even further. Read More

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http://dx.doi.org/10.1093/omcr/omaa041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315931PMC

Pathophysiology, prevention, and treatment of beriberi after gastric surgery.

Nutr Rev 2020 May 10. Epub 2020 May 10.

Upper Gastrointestinal Surgery Department, University of New South Wales, Liverpool Public Hospital, Liverpool, Sydney, New South Wales, Australia.

Beriberi is a nutritional complication of gastric surgery, caused by deficiency of vitamin B1, or thiamine. Thiamine deficiency leads to impaired glucose metabolism, decreased delivery of oxygen by red blood cells, cardiac dysfunction, failure of neurotransmission, and neuronal death. This review describes the history and pathophysiology of beriberi as well as the relationship between beriberi and nutritional deficiencies after gastric surgery. Read More

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http://dx.doi.org/10.1093/nutrit/nuaa004DOI Listing

Shoshin beriberi in a patient with oral and cutaneous graft-versus-host disease.

JAAD Case Rep 2020 May 29;6(5):420-421. Epub 2020 Apr 29.

Department of Dermatology, Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.1016/j.jdcr.2020.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200185PMC

Non-alcoholic beriberi, Wernicke encephalopathy and long-term eating disorder: case report and a mini-review.

Eat Weight Disord 2020 Mar 4. Epub 2020 Mar 4.

Neurology Unit, "A. Manzoni" Hospital-ASST Lecco, Via dell'Eremo 9/11, 23900, Lecco, Italy.

Introduction: Nowadays, reports of beriberi are rare in developed countries. Wernicke encephalopathy may be present in about 25% of patients with beriberi.

Case Report: We report the case of a woman with history of depression and chronic eating disorder, who complained Wernicke encephalopathy and beriberi. Read More

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http://dx.doi.org/10.1007/s40519-020-00880-0DOI Listing
March 2020
0.680 Impact Factor

Gastrointestinal Beriberi Mimicking a Surgical Emergency in a Well-Nourished Patient: A Case Report.

Mayo Clin Proc Innov Qual Outcomes 2019 Dec 2;3(4):506-509. Epub 2019 Nov 2.

Division of Trauma, Critical Care, and General Surgery, Mayo Clinic, Rochester, MN.

Beriberi is a well-documented disease caused by thiamine deficiency. The diagnosis of gastrointestinal beriberi in the clinical setting is uncommon, especially in nonalcoholic patients. Failure to recognize beriberi can result in devastating acute multisystem organ failure; however, timely treatment can result in rapid improvement in a patient's clinical status. Read More

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http://dx.doi.org/10.1016/j.mayocpiqo.2019.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978589PMC
December 2019

Development and Characterization of Monoclonal Antibodies for the Mycotoxin Citreoviridin.

Toxins (Basel) 2019 10 30;11(11). Epub 2019 Oct 30.

Department of Food and Life Science, Graduate School of Life and Environmental Sciences, Azabu University, Sagamihara, Kanagawa 252-5201, Japan.

Citreoviridin (CTV) in an inhibitor of mitochondrial ATPase that has been isolated from molded yellow rice and linked to the human disease Shoshin-kakke (acute cardiac beriberi). The disease results from a deficiency of thiamine, however, purified CTV can reproduce the symptoms in experimental animals. The link between CTV and Shoshin-kakke has been difficult to resolve, in part because cases of the disease are rare. Read More

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http://dx.doi.org/10.3390/toxins11110630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891493PMC
October 2019
1 Read

The Key to a Boy's Heart Is Through His Intestine.

Gastroenterology 2020 04 24;158(5):1226-1228. Epub 2019 Sep 24.

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.08.056DOI Listing

Gastrointestinal Beriberi and Wernicke's Encephalopathy Triggered by One Session of Heavy Drinking.

Case Rep Neurol 2019 Jan-Apr;11(1):124-131. Epub 2019 Apr 18.

Renown Institute for Neuroscience, Renown Health, Reno, Nevada, USA.

An otherwise healthy 30-year-old male acquired gastrointestinal beriberi and subsequent Wernicke's encephalopathy after 1 session of heavy drinking. Nausea, vomiting, and anorexia relentlessly progressed. The patient developed external ophthalmoplegia after 2 months. Read More

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http://dx.doi.org/10.1159/000499601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739701PMC
April 2019
5 Reads

Thiamine Deficiency in a Nondrinker and Secondary Pulmonary Edema after Thiamine Replenishment.

Intern Med 2020 Feb 18;59(3):373-376. Epub 2019 Sep 18.

Department of Internal Medicine, Tomakomai City Hospital, Japan.

A 48-year-old man was brought to our emergency room with acute abdominal pain and systemic edema, indicating acute circulatory failure with lactic acidosis. Furosemide treatment paradoxically worsened the systemic edema and induced confusion. He had no drinking history but hardly ate legumes or meats containing thiamine. Read More

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http://dx.doi.org/10.2169/internalmedicine.3585-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028406PMC
February 2020
2 Reads

Thiamine dose response in human milk with supplementation among lactating women in Cambodia: study protocol for a double-blind, four-parallel arm randomised controlled trial.

BMJ Open 2019 07 9;9(7):e029255. Epub 2019 Jul 9.

Mount Saint Vincent University, Halifax, Nova Scotia, Canada.

Introduction: Thiamine (vitamin B1) deficiency remains a concern in Cambodia where women with low thiamine intake produce thiamine-poor milk, putting their breastfed infants at risk of impaired cognitive development and potentially fatal infantile beriberi. Thiamine fortification of salt is a potentially low-cost, passive means of combating thiamine deficiency; however, both the dose of thiamine required to optimise milk thiamine concentrations as well as usual salt intake of lactating women are unknown.

Methods And Analysis: In this community-based randomised controlled trial, 320 lactating women from Kampong Thom, Cambodia will be randomised to one of four groups to consume one capsule daily containing 0, 1. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-029255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624064PMC
July 2019
4 Reads

Atypical presentation of a forgotten disease: refractory hypotension in beriberi.

Eur J Clin Nutr 2019 12 8;73(12):1598-1600. Epub 2019 Jul 8.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Background/objectives: Thiamine deficiency is a treatable disease with an excellent prognosis. However, it is often unrecognized because of the diversity of its clinical presentations.

Subjects/methods: Herein, we report two atypical cases of nonalcoholic thiamine deficiency that presented with refractory hypotension in the absence of lactic acidosis. Read More

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http://www.nature.com/articles/s41430-019-0469-y
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http://dx.doi.org/10.1038/s41430-019-0469-yDOI Listing
December 2019
3 Reads
2.709 Impact Factor

Thiamine and Heart Failure: Challenging Cases of Modern-Day Cardiac Beriberi.

Mayo Clin Proc Innov Qual Outcomes 2019 Jun 27;3(2):221-225. Epub 2019 May 27.

Department of Medicine, Hospitalist Division, VA Greater Los Angeles Healthcare System, Los Angeles, CA.

Cardiac beriberi, or heart failure due to thiamine deficiency, is considered rare in the developed world. The diagnosis is often only considered in limited populations such as those with chronic alcoholism. Alternatively, the disease can be mislabeled as "alcoholic cardiomyopathy" or "nonischemic cardiomyopathy. Read More

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http://dx.doi.org/10.1016/j.mayocpiqo.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543258PMC
June 2019
21 Reads

Possible involvement of thiamine insufficiency in heart failure in the institutionalized elderly.

J Clin Biochem Nutr 2019 May 6;64(3):239-242. Epub 2019 Feb 6.

Department of Food and Nutrition, Kyoto Women's University, 35 Kitahiyoshi-cho, Imakumano, Higashiyama, Kyoto 605-8501, Japan.

Heart failure is a major manifestation of thiamine deficiency; beriberi. Even thiamine insufficiency, milder than deficiency, may be associated with increased heart failure risk. In this cross-sectional study, the relationship between thiamine insufficiency and heart failure was investigated in the Japanese institutionalized elderly from April to November 2017. Read More

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http://dx.doi.org/10.3164/jcbn.18-85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529701PMC
May 2019
12 Reads

A Case of Ascending Sensory Neuropathy Due to Acute Onset Thiamine Deficiency After Intragastric Balloon Placement.

Obes Surg 2019 10;29(10):3404-3405

Department of Gastroenterology, Section of Advanced Endoscopy, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA.

Endoscopic bariatric therapies (EBTs) are emerging as nonsurgical weight loss interventions that are being used with increasing frequency. Similar to the potential for early and late complications from bariatric surgeries, metabolic derangements and nutritional deficiencies can also be seen after EBTs. In particular, thiamine deficiency is a well-known complication typically presenting with neurological symptoms, commonly Wernicke encephalopathy or dry beriberi. Read More

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http://link.springer.com/10.1007/s11695-019-03967-5
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http://dx.doi.org/10.1007/s11695-019-03967-5DOI Listing
October 2019
22 Reads

Acute Shoshin beriberi syndrome immediately post-kidney transplant with rapid recovery after thiamine administration.

Pediatr Transplant 2019 08 24;23(5):e13493. Epub 2019 May 24.

Multi Organ Transplant Program, BC Children's Hospital, Vancouver, British Columbia, Canada.

Pediatric kidney transplant surgery is usually well tolerated, despite suboptimal physical conditioning that may result from uremia and nutritional deficiencies that accompany end-stage kidney failure. Nutritional supplementation is used to overcome such deficiencies, especially for children needing dialysis. Thiamine, a water-soluble vitamin also known as vitamin B1, is a critical cofactor in energy metabolism and may be competitively inhibited by the antimetabolite oxythiamine, a uremic toxin that accumulates in kidney failure. Read More

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http://dx.doi.org/10.1111/petr.13493DOI Listing
August 2019
10 Reads

The discovery of beri-beri and scurvy vitamins - two hundred and two years from its discovery.

Int J Vitam Nutr Res 2019 Nov 8;89(5-6):225-226. Epub 2019 May 8.

National Researches Council of Italy, Institute of Molecular Bioimaging and Physiology, Research Section, Germaneto (Catanzaro), Italy.

The history of the discovery of vitamins was the history of their deficiency disorders. Casimir Funk, the father of vitaminic therapy, studied the interrelationships in the human body of those elements that Christiaan Eijkman demonstrated in animals, particularly birds. In 1911, he designated these factors vitamins (vita = life and amine, a nitrogenous substance essential for life); this name was accepted by the scientific community in 1912. Read More

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http://dx.doi.org/10.1024/0300-9831/a000435DOI Listing
November 2019
10 Reads

Shoshin Beriberi and Severe Accidental Hypothermia as Causes of Heart Failure in a 6-Year-Old Child: A Case Report and Brief Review of Literature.

Front Pediatr 2019 29;7:119. Epub 2019 Mar 29.

Pediatric Intensive Care Department, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Brussels, Belgium.

Severe accidental hypothermia has been demonstrated to affect ventricular systolic and diastolic functions, and rewarming might be responsible of cardiovascular collapse. Until now, there have been only a few reports on severe accidental hypothermia, none of which involved children. Herein, we describe here a rare case of heart failure in a 6-year-old boy admitted to the emergency unit owing to severe hypothermia and malnutrition. Read More

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http://dx.doi.org/10.3389/fped.2019.00119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449648PMC
March 2019
28 Reads

Beriberi neuropathy in oncological setting.

J Peripher Nerv Syst 2019 03;24(1):162-163

Neurosciences, University of Padova, Padova, Italy.

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http://dx.doi.org/10.1111/jns.12304DOI Listing
March 2019
1 Read

New-Onset Heart Failure.

JAMA Cardiol 2019 06;4(6):592-593

Department of Cardiology, Waterland Ziekenhuis, Purmerend, the Netherlands.

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http://dx.doi.org/10.1001/jamacardio.2019.0187DOI Listing
June 2019
3 Reads

Dry Beriberi Due to Thiamine Deficiency Associated with Peripheral Neuropathy and Wernicke's Encephalopathy Mimicking Guillain-Barré syndrome: A Case Report and Review of the Literature.

Am J Case Rep 2019 Mar 13;20:330-334. Epub 2019 Mar 13.

Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA.

BACKGROUND Beriberi due to thiamine (vitamin B1) deficiency has two clinical presentations. Patients with dry beriberi present with neuropathy, and patients with wet beriberi present with heart failure, with or without neuropathy. Dry beriberi can mimic the most common form of Guillain-Barre syndrome (GBS), an acute inflammatory demyelinating polyradiculoneuropathy (AIDP). Read More

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http://dx.doi.org/10.12659/AJCR.914051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429982PMC
March 2019
71 Reads

Thiamin deficiency in low- and middle-income countries: Disorders, prevalences, previous interventions and current recommendations.

Nutr Health 2019 Jun 24;25(2):127-151. Epub 2019 Feb 24.

6 Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, USA.

Background: Thiamin deficiency is a major public health concern in several low- and middle-income countries (LMICs)-current attention to the problem is lacking.

Aim: This review discusses prevalence of thiamin insufficiency and thiamin-deficiency disorders (TDDs) in LMICs, outlines programmatic experience with thiamin interventions, and offers recommendations to improve public-health and research attention to thiamin in LMICs.

Discussion: Thiamin insufficiency, i. Read More

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http://dx.doi.org/10.1177/0260106019830847DOI Listing
June 2019
1 Read

Role of Thiamin in Health and Disease.

Nutr Clin Pract 2019 Aug 15;34(4):558-564. Epub 2019 Jan 15.

Internal Medicine Department, Medical School, São Paulo State University (Unesp), Botucatu, São Paulo, Brazil.

Thiamin is a hydrosoluble vitamin that plays a role in several biological processes, mainly in glucose metabolism. There are several risk factors for developing thiamin deficiency, such as malnutrition, refeeding syndrome, gastrointestinal surgery, and alcoholism. Recently, the role of thiamin in critically ill patients has gained prominence, and the prevalence of thiamin deficiency was found to be increased in patients with severe burns, major surgery, septic shock, end-stage renal disease, and heart failure. Read More

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http://dx.doi.org/10.1002/ncp.10234DOI Listing
August 2019
19 Reads

Starvation-induced diplopia and weakness: a case of beriberi and Wernicke's encephalopathy.

BMJ Case Rep 2019 Jan 3;12(1). Epub 2019 Jan 3.

Department of Internal Medicine, Singapore General Hospital, Singapore.

A 56-year-old teetotaller man with hypertension and gout presented with a week duration of painless worsening diplopia on a background of loss of weight and appetite, generalised lethargy and weakness for 1 year. On examination, he was noted to be hypothermic and tachycardic with generalised muscle wasting. Proximal myopathy, lower limb fasciculations and areflexia, restricted bilateral eye abduction and nystagmus were observed. Read More

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http://dx.doi.org/10.1136/bcr-2018-227412DOI Listing
January 2019
64 Reads

Christiaan Eijkman (1856-1930).

J Neurol 2019 11 26;266(11):2893-2895. Epub 2018 Dec 26.

The Department of Spondyloorthopedics and Biomechanics of the Spine, University of Medical Sciences Poznań, 28 czerwca 1958 137/147, 61-501, Poznan, Poland.

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http://dx.doi.org/10.1007/s00415-018-9162-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803585PMC
November 2019
1 Read

Acute flaccid paralysis: Do not forget beriberi neuropathy.

J Peripher Nerv Syst 2019 Mar 16;24(1):145-149. Epub 2019 Jan 16.

Department of Neurology, National Neuroscience Institute, Singapore, Singapore.

We aimed to elucidate characteristics of beriberi neuropathy (BB) in a general hospital (GH) setting. Nerve conduction studies (NCS), cross-referenced with clinical records of patients admitted to a GH (May 2011-July 2017), were reviewed for diagnosis of BB. Thirteen patients (age range 23-64 years; five women) were diagnosed with BB. Read More

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http://dx.doi.org/10.1111/jns.12297DOI Listing
March 2019
16 Reads

The Wrong Turn to Tijuana: Dry Beriberi after Gastric Bypass Surgery with Incidental Spinal Stenosis.

Case Rep Neurol 2018 Sep-Dec;10(3):309-313. Epub 2018 Nov 8.

Internal Medicine, Mount Carmel West Hospital, Columbus, Ohio, USA.

Thiamine deficiency is a condition characterized by several different presentations, but one of the most devastating is dry beriberi. It is associated with polyneuropathy and muscle weakness which typically affects the lower extremities and progressively involves the upper extremities. This case outlines a case of a 41-year-old man that presented to the hospital with diffuse weakness and decreased sensation in his legs and hands over a 3-day period. Read More

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https://www.karger.com/Article/FullText/493422
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http://dx.doi.org/10.1159/000493422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276741PMC
November 2018
76 Reads

Beriberi disease in an 11-year-old girl with total colectomy.

Oxf Med Case Reports 2018 Nov 31;2018(11):omy091. Epub 2018 Oct 31.

Department of Pediatric Gastroenterology, Dayton Children's Hospital, Dayton, OH, USA.

Beriberi or vitamin B1 deficiency is a rare disease in the developed world and more common in developing countries due to poverty and malnutrition. It usually presents with neurological manifestations (dry beriberi) or cardiovascular signs (wet beriberi). We report a case of dry beriberi in an 11-year-old girl with total colectomy who presented to our hospital with ataxic gait and muscle weakness. Read More

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https://academic.oup.com/omcr/article/doi/10.1093/omcr/omy09
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http://dx.doi.org/10.1093/omcr/omy091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208053PMC
November 2018
45 Reads

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs.

Ann N Y Acad Sci 2018 10 27;1430(1):3-43. Epub 2018 Aug 27.

Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, Massachusetts.

Thiamine is an essential micronutrient that plays a key role in energy metabolism. Many populations worldwide may be at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on staple crops with low thiamine content, or food preparation practices, such as milling grains and washing milled rice. Clinical manifestations of thiamine deficiency are variable; this, along with the lack of a readily accessible and widely agreed upon biomarker of thiamine status, complicates efforts to diagnose thiamine deficiency and assess its global prevalence. Read More

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http://dx.doi.org/10.1111/nyas.13919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392124PMC
October 2018
17 Reads

Thiamine Deficiency: An Important Consideration in Critically Ill Patients.

Am J Med Sci 2018 10 21;356(4):382-390. Epub 2018 Jun 21.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas. Electronic address:

Thiamine is an essential cofactor for 4 enzymes involved in the production of energy (ATP) and the synthesis of essential cellular molecules. The total body stores of thiamine are relatively small, and thiamine deficiency can develop in patients secondary to inadequate nutrition, alcohol use disorders, increased urinary excretion and acute metabolic stress. Patients with sepsis are frequently thiamine deficient, and patients undergoing surgical procedures can develop thiamine deficiency. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029629183022
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http://dx.doi.org/10.1016/j.amjms.2018.06.015DOI Listing
October 2018
51 Reads

Gastrointestinal beriberi: a forme fruste of Wernicke's encephalopathy?

Authors:
Sanjay Prakash

BMJ Case Rep 2018 Jul 6;2018. Epub 2018 Jul 6.

Neurology, Smt B K Shah Medical Institute and Research Centre, Vadodara, Gujarat, India.

Gastrointestinal symptoms, such as anorexia, nausea, vomiting and abdominal pain, are very common in patients with Wernicke's encephalopathy (WE). Mild thiamine deficiency may have only gastrointestinal symptoms. We are reporting two patients with thiamine deficiency who predominantly had gastrointestinal symptoms. Read More

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http://dx.doi.org/10.1136/bcr-2018-224841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040496PMC
July 2018
15 Reads

Prevalence and predictors of postoperative thiamine deficiency after vertical sleeve gastrectomy.

Surg Obes Relat Dis 2018 07 1;14(7):950-951. Epub 2018 May 1.

Duke University Health System, Durham, North Carolina.

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http://dx.doi.org/10.1016/j.soard.2018.04.014DOI Listing
July 2018
16 Reads

Re-emergence of thiamine deficiency disease in the Pacific islands (2014-15): A case-control study.

PLoS One 2018 7;13(6):e0198590. Epub 2018 Jun 7.

Ministry of Health and Medical Services, Nawerewere, Tarawa, Kiribati.

Background: From late 2014 multiple atolls in Kiribati reported an unusual and sometimes fatal illness. We conducted an investigation to identify the etiology of the outbreak on the most severely affected atoll, Kuria, and identified thiamine deficiency disease as the cause. Thiamine deficiency disease has not been reported in the Pacific islands for >5 decades. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198590PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991702PMC
January 2019
20 Reads

Guillain-Barré syndrome mimics.

Brain Behav 2018 05 10;8(5):e00960. Epub 2018 Apr 10.

Department of Neurology National Neuroscience Institute Singapore City Singapore.

The Brighton Collaboration criteria have standardized the clinical and laboratory-supported diagnosis of Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) in a way that is applicable in many parts of the world with variable resources. The caveat within the criteria, "absence of an identified alternative diagnosis for weakness" makes GBS a diagnosis of exclusion. Accurate diagnosis of GBS requires a good understanding of an updated, locally contextualised list of mimics, and features that distinguish them from GBS. Read More

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http://doi.wiley.com/10.1002/brb3.960
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http://dx.doi.org/10.1002/brb3.960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943729PMC
May 2018
22 Reads

Wet beriberi with multiple organ failure remarkably reversed by thiamine administration: A case report and literature review.

Medicine (Baltimore) 2018 Mar;97(9):e0010

Department of Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Rationale: Circulatory failure, especially with low systemic vascular resistance (SVR), as observed in septic shock, thyrotoxicosis, and anemia, is a particular pattern that should suggest thiamine (vitamin B1) deficiency. The clinical picture of wet beriberi secondary to thiamine deficiency only demonstrates non-specific clinical manifestations. For a diagnosis of wet beriberi, medical history is very important. Read More

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http://dx.doi.org/10.1097/MD.0000000000010010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851725PMC
March 2018
22 Reads

Thiamin.

Authors:
Derrick Lonsdale

Adv Food Nutr Res 2018;83:1-56. Epub 2018 Feb 2.

Cleveland Clinic, Cleveland, OH, United States. Electronic address:

Starting with a brief history of beriberi and the discovery that thiamin deficiency is its cause, the symptoms and signs are reviewed. None are pathognomonic. The disease has a low mortality and a long morbidity. Read More

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http://dx.doi.org/10.1016/bs.afnr.2017.11.001DOI Listing
May 2018
35 Reads

Thiamine and Cardiovascular Disease: A Literature Review.

Prog Cardiovasc Dis 2018 May - Jun;61(1):27-32. Epub 2018 Jan 31.

Saint Luke's Mid America Heart Institute, Kansas City, MO, United States.

Thiamine is a water-soluble vitamin that plays an important role in the energy metabolism in the human body. Deficiency in thiamine can lead to neurological abnormalities and congestive heart failure (HF), known as dry beriberi and wet beriberi respectively. Several populations are at higher risk for thiamine deficiency, most notably persons with chronic alcoholism. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.01.009DOI Listing
October 2018
14 Reads

Wet Beriberi Associated with Hikikomori Syndrome.

J Gen Intern Med 2018 03 29;33(3):384-387. Epub 2017 Nov 29.

Department of Critical Care Medicine, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu-city, Japan.

Wet beriberi, characterized by high cardiac output with predominantly right-sided heart failure and lactic acidosis, is a disease caused by thiamine deficiency, and is rarely seen in modern society. However, patients with social withdrawal syndrome, also known as hikikomori syndrome, may be a new population at risk of thiamine deficiency. Hikikomori syndrome, first recognized in Japan, is becoming a worldwide issue. Read More

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http://dx.doi.org/10.1007/s11606-017-4208-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834955PMC
March 2018
41 Reads

Beriberi Outbreak Among Unauthorised Immigrants in a Detention Camp in Malaysia.

J Immigr Minor Health 2018 Oct;20(5):1294-1297

Community and Family Medicine Department, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Jalan UMS, 88300, Kota Kinabalu, Sabah, Malaysia.

In February 2012, a district health authority received three inmates with bilateral leg swelling and difficulty in breathing from a detention camp for unauthorized immigrants. A case control study was conducted. Fasting blood samples of case and control groups were collected according to instructions of the laboratory for determining thiamine level, and their 1 week dietary intake was analyzed. Read More

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http://dx.doi.org/10.1007/s10903-017-0674-5DOI Listing
October 2018
13 Reads

Usefulness of central venous saturation as a predictor of thiamine deficiency in critically ill patients: a case report.

J Intensive Care 2017 6;5:61. Epub 2017 Nov 6.

Department of Cardiovascular Medicine, Graduate school of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 1130033 Japan.

Background: Central venous oxygen saturation (ScvO) reflects the balance of oxygen delivery and consumption. Low ScvO indicates the presence of inadequate oxygen delivery, while high ScvO indicates reduced oxygen consumption and is sometimes associated with a high mortality rate in critically ill patients from dysoxia. Thiamine is an essential cofactor in cellular aerobic metabolism. Read More

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http://dx.doi.org/10.1186/s40560-017-0255-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674760PMC
November 2017
63 Reads

Wernicke-Korsakoff syndrome complicated by subacute beriberi neuropathy in an alcoholic patient.

Clin Neurol Neurosurg 2018 01 8;164:1-4. Epub 2017 Nov 8.

Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, Italy. Electronic address:

Thiamine (vitamin B1) deficiency is a common condition in alcohol abusers, which can lead to damage of both the peripheral and the central nervous systems. Here we describe the case of an alcoholic patient who presented with acute onset of ataxia, severe weakness of the four limbs, and hypoesthesia and dysesthesia of the distal portion of the upper and lower extremities. The clinical picture also included mental confusion and amnesia. Read More

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http://dx.doi.org/10.1016/j.clineuro.2017.11.006DOI Listing
January 2018
32 Reads

A diagnosis and treatment gap for thiamine deficiency disorders in sub-Saharan Africa?

Ann N Y Acad Sci 2017 11 24;1408(1):15-19. Epub 2017 Oct 24.

Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee.

Staple diets that are deficient in thiamine can result in low body thiamine levels, which may be subclinical or may manifest as a thiamine-deficiency syndrome. In many communities in the developing countries of Africa, the staple diets of polished rice or processed cassava are deficient in thiamine, and thus the communities are at high risk for marginal or frank thiamine deficiency unless their diets are supplemented by other sources of thiamine, such as protein meals and vegetables. African communities with large numbers of individuals in low socioeconomic strata are more likely to subsist on a monotonous diet of rice or cassava with minimal or no protein supplementation and are therefore particularly at risk of thiamine-deficiency disorders. Read More

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http://dx.doi.org/10.1111/nyas.13509DOI Listing
November 2017
10 Reads

Thiamine content of F-75 therapeutic milk for complicated severe acute malnutrition: time for a change?

Ann N Y Acad Sci 2017 09 14;1404(1):20-26. Epub 2017 Sep 14.

Pediatric Neurology Unit, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Since community-based management of severe acute malnutrition has become the standard of care, the clinical profile of severe acutely malnourished patients admitted to hospitals or inpatient therapeutic feeding centers has changed significantly. These patients are usually very ill and often present with several comorbidities, such as shock, sepsis, and pneumonia. Complicated severe acute malnutrition patients are at risk of thiamine insufficiency, and critically ill patients have higher thiamine requirements. Read More

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http://dx.doi.org/10.1111/nyas.13458DOI Listing
September 2017
14 Reads

High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children.

PLoS Negl Trop Dis 2017 Sep 5;11(9):e0005814. Epub 2017 Sep 5.

Institute of Research for Development (IRD), UMR-204, IRD-UM-SupAgro, Montpellier, France.

Background: Thiamine deficiency is thought to be an issue in Cambodia and throughout Southeast Asia due to frequent clinical reports of infantile beriberi. However the extent of this public health issue is currently unknown due to a lack of population-representative data. Therefore we assessed the thiamine status (measured as erythrocyte thiamine diphosphate concentrations; eThDP) among a representative sample of Cambodian women of childbearing age (15-49 y) and their young children (6-69 mo). Read More

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http://dx.doi.org/10.1371/journal.pntd.0005814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600402PMC
September 2017
25 Reads

Nonalcoholic Wernicke's Encephalopathy: A Retrospective Study from a Tertiary Care Center in Northern India.

J Neurosci Rural Pract 2017 Jul-Sep;8(3):401-406

Department of Food Sciences and Technology, University of Kashmir, Srinagar, Jammu and Kashmir, India.

Objective: The objective of this study was to describe the demographic features, clinical presentation, and management and outcome of fifty cases of nonalcoholic Wernicke's encephalopathy from a tertiary care hospital of a region with reported incidence of thiamine deficiency disorders.

Materials And Methods: In a retrospective study, fifty adult cases of Wernicke's encephalopathy were analyzed. The diagnosis of Wernicke's encephalopathy was made according to the European federation of neurological societies guidelines 2010. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_14_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488561PMC
July 2017
22 Reads

Wernicke's encephalopathy in exclusive breastfed infants.

World J Pediatr 2017 Oct 24;13(5):485-488. Epub 2017 May 24.

Department of Pediatrics, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India.

Background: Kashmir has a population that largely consumes polished rice which is deficient in thiamine. Furthermore, lactating women in this region are prone to severe thiamine deficiency because of their traditional food avoidance practices. Infantile beriberi is common in exclusively breastfed infants of thiamine deficient mothers in Kashmir. Read More

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http://dx.doi.org/10.1007/s12519-017-0039-0DOI Listing
October 2017
43 Reads

A Large Outbreak of Thiamine Deficiency Among Illegal Gold Miners in French Guiana.

Am J Trop Med Hyg 2017 05;96(5):1248-1252

Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane, Cayenne, French Guiana, France.

From September 2013 to July 2014, several gold miners working in the tropical forest consulted the Maripasoula Health Center in French Guiana for edema and findings consistent with right-sided cardiac failure. Of the 42 cases of beriberi that were diagnosed, one patient died. The laboratory and clinical investigation demonstrated vitamin B1 deficiency in most of the patients tested. Read More

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http://dx.doi.org/10.4269/ajtmh.15-0906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417225PMC
May 2017
75 Reads

No Camphor Toxicity in Cambodian Infants.

Glob Pediatr Health 2017 24;4:2333794X17702980. Epub 2017 Apr 24.

Mayo Clinic, Rochester, MN, USA.

Thiamine deficiency and beriberi are prevalent in Cambodia, although most infants with nonspecific clinical symptoms of beriberi, including tachypnea, lack echocardiographic evidence diagnostic of the disease. Camphor activates transient receptor potential vanilloid 3 (TRPV3), a nonselective ion channel expressed in the medial preoptic nucleus of the hypothalamus and thought to be important for thermo-sensitivity. Because camphorated ointments are used commonly among Cambodian infants, we hypothesized that topical camphor modulates thermoregulatory behaviors, causing beriberi-simulating tachypnea, separate from any influence of thiamine deficiency. Read More

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http://dx.doi.org/10.1177/2333794X17702980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406147PMC
April 2017
38 Reads

Thiamine Assays-Advances, Challenges, and Caveats.

ChemistryOpen 2017 04 8;6(2):178-191. Epub 2017 Mar 8.

Department of Natural Resources Cornell University Ithaca NY 14853 USA.

Thiamine (vitamin B1) is essential to the health of all living organisms and deficiency has long been associated with diseases in animals such as fish, birds, alligators, and domesticated ruminant mammals. Thiamine is also implicated in several human diseases including Alzheimer's, diabetes, dementia, depression and, most notably, Wernicke-Korsakoff syndrome and Beriberi disease. Yet, highly sensitive and specific detection of thiamine remains an analytical challenge, as pM to nm levels of thiamine need to be detected in environmental and human samples, respectively, various phosphorylated variants need to be discriminated, and rapid on-site detection would be highly desirable. Read More

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http://dx.doi.org/10.1002/open.201600160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390807PMC
April 2017
23 Reads

[Wernicke encephalopathy and dry beriberi; late complications after bariatric surgery performed on a patient with a psychiatric history].

Tijdschr Psychiatr 2017 ;59(2):116-120

A 38-year-old woman was admitted in a psychiatric hospital because of memory disorders. Dry beriberi and Korsakoff's syndrome, as a late neuropsychiatric manifestation of Wernicke's encephalopathy, were established. The beriberi symptoms decreased slowly, but the patient's memory impairments persisted. Read More

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February 2018
16 Reads