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    797 results match your criteria Beriberi Thiamine Deficiency

    1 OF 16

    Prevalence of clinical thiamine deficiency in individuals with medically complicated obesity.
    Nutr Res 2017 Jan 1;37:29-36. Epub 2016 Dec 1.
    Center for Advanced Laparoscopic General & Bariatric Surgery, MedStar-Washington Hospital Center and Georgetown University School of Medicine, Washington, DC 20010, USA. Electronic address:
    Thiamine is a vitamin whose deficient can result in multiorgan symptoms. We described an 18% prevalence of clinical thiamine deficiency after gastric bypass surgery. Our hypotheses are that individuals with medically complicated obesity frequently have clinical thiamine deficiency and that diabetes mellitus is a mechanism for development of clinical thiamine deficiency. Read More

    Thiamine Deprivation Produces a Liver ATP Deficit and Metabolic and Genomic Effects in Mice: Findings Are Parallel to Those of Biotin Deficiency and Have Implications for Energy Disorders.
    J Nutrigenet Nutrigenomics 2017 Feb 18;9(5-6):287-299. Epub 2017 Feb 18.
    Unidad de Genética de la Nutrición, Instituto de Investigaciones Biomédicas UNAM - Instituto Nacional de Pediatría, Mexico City, Mexico.
    Thiamine is one of several essential cofactors for ATP generation. Its deficiency, like in beriberi and in the Wernicke-Korsakoff syndrome, has been studied for many decades. However, its mechanism of action is still not completely understood at the cellular and molecular levels. Read More

    Beriberi Induced Cardiomyopathy Requiring Salvage Venoarterial Extracorporeal Membrane Oxygenation.
    Case Rep Crit Care 2016 5;2016:5043818. Epub 2016 Dec 5.
    Advocate Christ Medical Center, Oak Lawn, IL, USA.
    Beriberi refers to a constellation of symptoms caused primarily by thiamine (vitamin B1) deficiency. An acute and fulminant presentation of this rare condition has been described in the literature as "Shoshin" beriberi which is characterized by catastrophic cardiovascular collapse. Early recognition and treatment lead to dramatic improvements of symptoms. Read More

    [Beriberi 10 years after gastric bypass surgery - case report].
    Laeknabladid 2016 Nov;102(11):497-499
    Beriberi is primarily related to malnutrition, but also known as a complication following abdominal surgical procedures. A 41 year old woman, who underwent gastric bypass surgery 10 years earlier, presented at the emergency department of Landspitali with general weakness and paresthesia. Physical examination revealed muscle atrophy and attenuated deep tendon reflexes in her lower limbs; presenting as polyneuropathy due to beriberi. Read More

    Perinatal Consumption of Thiamine-Fortified Fish Sauce in Rural Cambodia: A Randomized Clinical Trial.
    JAMA Pediatr 2016 Oct 3;170(10):e162065. Epub 2016 Oct 3.
    Food, Nutrition, and Health, University of British Columbia, Vancouver, British Columbia, Canada9South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia10Discipline of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia.
    Importance: Infantile beriberi, a potentially fatal disease caused by thiamine deficiency, remains a public health concern in Cambodia and regions where thiamine-poor white rice is a staple food. Low maternal thiamine intake reduces breast milk thiamine concentrations, placing breastfed infants at risk of beriberi.

    Objective: To determine if consumption of thiamine-fortified fish sauce yields higher erythrocyte thiamine diphosphate concentrations (eTDP) among lactating women and newborn infants and higher breast milk thiamine concentrations compared with a control sauce. Read More

    An unusual case of cardiogenic shock in which thiamine administration led to reversal of lactic acidosis and heart function recovery: Shoshin beriberi in an adolescent.
    Int J Cardiol 2016 Nov 30;222:401-3. Epub 2016 Jul 30.
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.

    Thiamine Deficiency in Tropical Pediatrics: New Insights into a Neglected but Vital Metabolic Challenge.
    Front Nutr 2016 14;3:16. Epub 2016 Jun 14.
    Pediatric Team, Medical Department, Médecins Sans Frontières (MSF) , Barcelona , Spain.
    In humans, thiamine is a micronutrient prone to depletion that may result in severe clinical abnormalities. This narrative review summarizes current knowledge on thiamine deficiency (TD) and bridges the gap between pathophysiology and clinical presentation by integrating thiamine metabolism at subcellular level with its function to vital organs. The broad clinical spectrum of TD is outlined, with emphasis on conditions encountered in tropical pediatric practice. Read More

    Acute Abdominal Pain as a Presenting Symptom of Beriberi in a Pediatric Patient.
    J Trop Pediatr 2016 Dec 20;62(6):490-495. Epub 2016 Jun 20.
    Departamento de Pediatria, Faculdade de Ciências Médicas, Universidade Estadual de Campinas - UNICAMP - São Paulo, CP 6109, Brazil
    Vitamin B1 (thiamine) plays a fundamental role in the proper functioning of the nervous and cardiovascular systems and in glucose metabolism. Because of the inability of the human body to store large amounts of vitamin, continuous restoration through diet is necessary. In the pediatric population, thiamine deficiency has a broad spectrum of clinical presentations, making diagnosis difficult. Read More

    The influence of infantile thiamine deficiency on primary dentition.
    Clin Oral Investig 2016 Jun 17. Epub 2016 Jun 17.
    Pediatric Dental Unit, Barzilai Medical Center, Ashkelon, Israel.
    Objectives: The present study explored the histological and chemical effects of infantile thiamine deficiency (ITD) on enamel development through the examination of exfoliated deciduous teeth from a patient who had been fed during his first year of life with a thiamine-deficient milk substitute.

    Materials And Methods: Ground sections derived from six exfoliated primary teeth were examined. Slices from a light microscope were photographed for histological analysis. Read More

    [Clinical appearance and scalable profile Thiamine deficiency in prison in Guinea: study of thirty-eight observations].
    Bull Soc Pathol Exot 2016 May 29;109(2):70-6. Epub 2016 Mar 29.
    CHU, Conakry, Guinée.
    Cardiovascular and neurological manifestations associated with thiamine deficiency in Guinean prisons are common but not reported.We performed a prospective study of 38 cases related to vitamin B1 deficiency over a period of 4 years. In this population, the literature of traditional data gathered: frequency peak after thirty (92. Read More

    Case report: pericardial effusion with constrictive physiology in a patient with wet beriberi.
    Nutr J 2016 Apr 8;15:37. Epub 2016 Apr 8.
    Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa, University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
    Wet beriberi-induced pericardial effusion has rarely been previously described. Little is known about the effect of beriberi-induced pericardial effusion on hemodynamics. Here we present a case of wet beriberi with pericardial effusion that exhibited constrictive physiology, which was dramatically improved after treatment. Read More

    Thiamine deficiency in tachypnoeic Cambodian infants.
    Paediatr Int Child Health 2015 ;35(4):312-8
    Mayo Medical School.
    Background: Beriberi is endemic in South-east Asia. Diagnosis is based on clinical findings, but correlation of clinical features with blood thiamine concentrations is uncertain.

    Objectives: To investigate in tachypnoeic Cambodian infants the correlation between whole blood thiamine diphosphate (TDP) concentrations, clinical findings and blood TDP levels after therapy. Read More

    Wernicke's Encephalopathy, Wet Beriberi, and Polyneuropathy in a Patient with Folate and Thiamine Deficiency Related to Gastric Phytobezoar.
    Case Rep Neurol Med 2015 30;2015:624807. Epub 2015 Nov 30.
    Severo Ochoa Hospital, Leganés, 28911 Madrid, Spain.
    Background. Wernicke's encephalopathy (WE) is an acute neurological disorder resulting from thiamine deficiency. It is mainly related to alcohol abuse but it can be associated with other conditions such as gastrointestinal disorders. Read More

    High-Output Heart Failure Caused by Thyrotoxicosis and Beriberi.
    Crit Care Nurs Clin North Am 2015 Dec 2;27(4):499-510. Epub 2015 Sep 2.
    Sutter Medical Center, 2801 L Street, Sacramento, CA 95816, USA. Electronic address:
    High-output heart failure is not seen as commonly as low-output heart failure and some of the typical guideline recommendations may not benefit patients with high-output failure. High-output failure is caused by several diseases, including thyrotoxicosis and beriberi, highlighted in this article. Thyrotoxicosis, caused by excessive thyroid hormone production, has profound hemodynamic effects. Read More

    Dry beriberi preceded Wernicke's encephalopathy: Thiamine deficiency after laparoscopic sleeve gastrectomy.
    J Pediatr Neurosci 2015 Jul-Sep;10(3):297-9
    Division of Child Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
    In recent times, pediatric obesity has become widely prevalent. If first-line treatment with lifestyle modification fails, bariatric surgery may be indicated for severely obese patients. Many patients now travel abroad to get these surgeries done. Read More

    Thiamine responsive acute life threatening metabolic acidosis in exclusively breast-fed infants.
    Nutrition 2016 Feb 2;32(2):213-6. Epub 2015 Sep 2.
    GMC Srinagar, GB Pant Hospital, Department of Pediatrics, Kashmir, India.
    Background: Acute life threatening metabolic acidosis in exclusively breast fed infants due to thiamine deficiency is not described. Kashmir valley, a north Indian state has a population that largely consumes polished rice.

    Methods: A six months prospective descriptive study of infants who presented with acute life threatening metabolic acidosis (Blood pH ≤ 7. Read More

    [An Uncommon Diagnosis].
    Praxis (Bern 1994) 2015 Oct;104(21):1151-6
    1 Universitätsklinik für Endokrinologie, Diabetologie und Klinische Ernährung, Inselspital Bern.
    We report on a 61-year-old patient who suffered from severe protein-energy malnutrition due to an inadequately treated exocrine pancreatic insufficiency. In this context, a thiamine deficiency was not recognized and there were clinical manifestations of beriberi disease with decompensated biventricular heart failure. In the course of time, a manifest niacin deficiency (pellagra) with dermatitis, diarrhea and persistent delirium occurred, which was recognized and could be treated. Read More

    Sudden infant death syndrome and abnormal metabolism of thiamin.
    Med Hypotheses 2015 Dec 14;85(6):922-6. Epub 2015 Sep 14.
    Associate Emeritus, Cleveland Clinic Foundation, Cleveland, OH, United States. Electronic address:
    Although it has been generally accepted that moving the infant from the prone to the supine position has solved the problem of sudden infant death syndrome (SIDS), it has been hypothesized that this is an insufficient explanation and that a mixture of genetic risk, some form of stressful incident and marginal brain metabolism is proportionately required. It is suggested that each of these three variables, with dominance in one or more of them, act together in the common etiology. Much has been written about the association of thiamin and magnesium but the finding of extremely high concentrations of serum thiamin in SIDs victims has largely caused rejection of thiamin as being involved in the etiology. Read More

    Enhancement of Thiamin Content in Arabidopsis thaliana by Metabolic Engineering.
    Plant Cell Physiol 2015 Dec 9;56(12):2285-96. Epub 2015 Oct 9.
    Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97330, USA Hermiston Agricultural Research and Extension Center, Oregon State University, 2121 S First Street, Hermiston, OR 97838, USA
    Thiamin is an essential nutrient in the human diet. Severe thiamin deficiency leads to beriberi, a lethal disease which is common in developing countries. Thiamin biofortification of staple food crops is a possible strategy to alleviate thiamin deficiency-related diseases. Read More

    Shoshin Beriberi With Low Cardiac Output and Hemodynamic Deterioration Treated Dramatically by Thiamine Administration.
    Int Heart J 2015 4;56(5):568-70. Epub 2015 Sep 4.
    Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, The University of Tokyo.
    "Shoshin beriberi", which is a fulminant form of cardiovascular beriberi accompanied by hemodynamic deterioration with high cardiac output and decreased systemic blood pressure, caused by thiamine deficiency due to alcoholic abuse or malnutrition, is often difficult to address because of its rarity and non-specific symptoms. We here present a patient with a history of alcoholic abuse who had suffered hemodynamic deterioration with extremely low cardiac output refractory to extracorporeal membrane oxygenation and intravenous catecholamine support, which was improved dramatically by bolus intravenous thiamine administration. Such a type with low cardiac output would be the most severe form of Shoshin beriberi, and cannot be rescued without diagnostic administration of thiamine. Read More

    Infantile encephalitic beriberi: magnetic resonance imaging findings.
    Pediatr Radiol 2016 Jan 19;46(1):96-103. Epub 2015 Aug 19.
    Department of Pediatrics, Government Medical College Srinagar, Jammu and Kashmir, India.
    Background: Thiamine deficiency in infants is still encountered in developing countries. It may present with acute neurological manifestations of infantile encephalitic beriberi.

    Objective: To review brain MRI findings in infantile encephalitic beriberi from a single institution. Read More

    The Japanese Hospital in Broome, 1910-1926. A harmony of contrasts.
    J R Coll Physicians Edinb 2015 ;45(2):156-64
    P Stride, University of Queensland School of Medicine, Brisbane, Queensland 4012, Australia. Email
    The Japanese Hospital in Broome remains the only hospital in Australia's history predominantly staffed, controlled and funded by a linguistically, culturally and geographically alien nation. Initially the proposal, challenging prevailing attitudes, was bitterly opposed by the white community, but the hospital became respected thanks to Dr Tadashi Suzuki, the hospital's first doctor, and his successors' clinical skills and compassion. Read More

    [Experimental Approach to Analysis of the Relationship between Food Environments and Lifestyle-Related Diseases, Including Cardiac Hypertrophy, Fatty Liver, and Fatigue Symptoms].
    Nihon Eiseigaku Zasshi 2015 ;70(2):110-4
    Department of Hygiene and Health Promotion Medicine, Kagoshima University Graduate School of Medical and Dental Sciences.
    The food habit is involved in the onset and development of lifestyle-related diseases. In this review I would like to describe a historical case of vitamin B1 deficiency, as well as our case study of fatty acid metabolism abnormality due to carnitine deficiency. In history, the army and navy personnel in Japan at the end of the 19th century received food rations based on a high-carbohydrate diet including white rice, resulting in the onset of beriberi. Read More

    Shoshin Beriberi in Critically-Ill patients: case series.
    Nutr J 2015 May 17;14:51. Epub 2015 May 17.
    Department of Medicine, Kidney and Dialysis Research Laboratory, Division of Nephrology, St. Elizabeth's Medical Center, 736 Cambridge Street, 02135, Boston, MA, USA.
    Thiamine plays a fundamental role in cellular metabolism. The classical syndrome caused by thiamine deficiency is beriberi, and its fulminant variant, once considered an uncommon finding, is now encountered among the critically ill.We present a case series of four critically ill non-septic non-alcoholic patients with severe lactic acidosis and refractory cardio-circulatory collapse caused by acute fulminant beriberi, which drastically responded to thiamine administration. Read More

    Elevated Lactate Secondary to Gastrointestinal Beriberi.
    J Gen Intern Med 2016 Jan 16;31(1):133-6. Epub 2015 Apr 16.
    The Queen's Medical Center, 1301 Punchbowl St., Honolulu, 96813, HI, USA.
    Thiamine deficiency usually occurs with prolonged nutritional deficiency and is almost universally identified with Wernicke's encephalopathy or beriberi. It is also, however, a rare cause of elevated lactate and gastroenterological symptoms. This case report describes a 30-year-old man with 2 weeks of gastroenterological symptoms and intermittent oral intake, who was found to have an elevated lactate level. Read More

    Beriberi (thiamine deficiency) and high infant mortality in northern Laos.
    PLoS Negl Trop Dis 2015 Mar 17;9(3):e0003581. Epub 2015 Mar 17.
    Institut de la Francophonie pour la Médecine Tropicale, Vientiane, Lao, PDR.
    Background: Infantile beriberi (thiamine deficiency) occurs mainly in infants breastfed by mothers with inadequate intake of thiamine, typically among vulnerable populations. We describe possible and probable cases of infantile thiamine deficiency in northern Laos.

    Methodology/principal Findings: Three surveys were conducted in Luang Namtha Province. Read More

    Poor thiamin and riboflavin status is common among women of childbearing age in rural and urban Cambodia.
    J Nutr 2015 Mar 7;145(3):628-33. Epub 2015 Jan 7.
    Food, Nutrition, and Health and
    Background: Thiamin deficiency in infancy is the underlying cause of beriberi, which can be fatal without rapid treatment. Reports of thiamin deficiency are common in Cambodia; however, population representative data are unavailable. Because B-complex vitamin deficiencies commonly occur in combination, riboflavin was also investigated. Read More

    Clinicopathologic features of folate-deficiency neuropathy.
    Neurology 2015 Mar 6;84(10):1026-33. Epub 2015 Feb 6.
    From the Department of Neurology (H.K., M.T., K.O., R.H., Y.K., M.I., M.K., G.S.), Nagoya University Graduate School of Medicine; and Department of Neurology and Stroke Medicine (H.D., F.T.), Yokohama City University Graduate School of Medicine, Japan.
    Objective: The clinical significance and characteristics of neuropathy caused by folate deficiency remain to be established.

    Methods: We examined the clinicopathologic features of 18 consecutive patients with neuropathy caused by folate deficiency who presented with low serum folate levels but normal blood thiamine and serum cobalamin levels in the absence of chronic alcoholism.

    Results: Symptoms were relatively uniform, characterized by slowly progressive polyneuropathy with predominant involvement of the lower extremities, with a tendency to manifest as sensory rather than motor neuropathy and predominant deep rather than superficial sensory loss. Read More

    A case of shoshin beriberi presenting as cardiogenic shock with diffuse ST-segment elevation, which dramatically improved after a single dose of thiamine.
    Cardiovasc J Afr 2014 Nov 23;25(6):e1-5. Epub 2014 Nov 23.
    Department of Internal Medicine, Konkuk University Hospital, School of Medicine, Konkuk University, Seoul, Korea.
    Shoshin beriberi is a fulminant form of cardiac beriberi caused by thiamine deficiency. We report on a case of an 87-year-old man with shoshin beriberi presenting as cardiogenic shock with diffuse ST-segment elevation, which dramatically improved after thiamine administration. Because of the rarity of the occurrence, lack of diagnostic test and atypical presentation, diagnosing shoshin beriberi is challenging and requires a high index of clinical suspicion. Read More

    Thiamine Deficiency in a Developed Country: Acute Lactic Acidosis in Two Neonates Due to Unsupplemented Parenteral Nutrition.
    JPEN J Parenter Enteral Nutr 2016 Aug 15;40(6):886-9. Epub 2015 Jan 15.
    Department of Neonatology, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
    Thiamine is a water-soluble vitamin implicated in several metabolic processes. Its deficiency, due to prolonged parenteral nutrition without adequate vitamin supplementation, can lead to multiorgan failure characterized by cardiovascular impairment and metabolic acidosis refractory to bicarbonate administration. Only thiamine administration allows the remission of symptoms. Read More

    Thiamine and magnesium deficiencies: keys to disease.
    Med Hypotheses 2015 Feb 15;84(2):129-34. Epub 2014 Dec 15.
    Associate Emeritus, Cleveland Clinic, Cleveland, OH, United States. Electronic address:
    Thiamine deficiency (TD) is accepted as the cause of beriberi because of its action in the metabolism of simple carbohydrates, mainly as the rate limiting cofactor for the dehydrogenases of pyruvate and alpha-ketoglutarate, both being critical to the action of the citric acid cycle. Transketolase, dependent on thiamine and magnesium, occurs twice in the oxidative pentose pathway, important in production of reducing equivalents. Thiamine is also a cofactor in the dehydrogenase complex in the degradation of the branched chain amino acids, leucine, isoleucine and valine. Read More

    Thiamine deficiency in tachypnoeic Cambodian infants.
    Paediatr Int Child Health 2014 Oct 27:2046905514Y0000000162. Epub 2014 Oct 27.
    Background: Beriberi is endemic in South-east Asia. Diagnosis is based on clinical findings, but correlation of clinical features with blood thiamine concentrations is uncertain. Objectives: To investigate in tachypnoeic Cambodian infants the correlation between whole blood thiamine diphosphate (TDP) concentrations, clinical findings and blood TDP levels after therapy. Read More

    [The disease called "Barbiers" in the 19th century].
    Med Sante Trop 2014 Jul-Sep;24(3):241-6
    Centre René-Labusquière, université de Bordeaux, 33076 Bordeaux, France.
    Described by French, English, and Dutch physicians, the disease known as Barbiers struck the island of Reunion in 1805, 1821, 1838 and 1847. It also ravaged India and other parts of the world during the 19(th) century. The origin of the name Barbiers nonetheless remains unknown. Read More

    Shoshin beriberi induced by long-term administration of diuretics: a case report.
    Case Rep Cardiol 2014 3;2014:878915. Epub 2014 Jul 3.
    Department of Cardiology, Toyota Memorial Hospital, 1-1 Heiwa-cho, Toyota 471-8513, Japan.
    Previous studies have suggested that diuretic therapy for heart failure may lead to thiamine deficiency due to the increased urinary thiamine excretion. Herein, we present the case of a 61-year-old man with shoshin beriberi, a fulminant form of wet beriberi, induced by long-term diuretic therapy. The patient had a history of heart failure with preserved ejection fraction and was receiving furosemide and trichlormethiazide therapy. Read More

    Beriberi, a severe complication after metabolic surgery - review of the literature.
    Obes Facts 2014 30;7(4):246-52. Epub 2014 Jul 30.
    SRH Municipal Hospital, Department of General, Abdominal and Pediatric Surgery, Gera, Germany.
    Background: The epidemic growth of morbid obesity has led to an increase in the number of bariatric interventions. During the distribution process of bariatric surgical interventions, the risk for severe nutritious complications such as bariatric beriberi can rise.

    Methods: By means of systematic literature review, epidemiological data, clinical characteristics and diagnostic as well as therapeutic recommendations for bariatric beriberi were elicited. Read More

    [Sometimes they come back! A case of Shoshin Beriberi in Northern Italy (2012)].
    Recenti Prog Med 2014 Jul-Aug;105(7-8):303-6
    A 78-year-old man presented to the emergency department with symptoms and signs suggestive of heart failure. Only after a long interview we discovered that the patient has been eating, for over 20 years, only chestnut honey and chestnut jam produced by himself. He refused any other foods, because of the fear of being poisoned; he did not drink alcohol at all. Read More

    Thiamine deficiency secondary to anorexia nervosa: an uncommon cause of peripheral neuropathy and Wernicke encephalopathy in adolescence.
    Pediatr Neurol 2014 Jul 30;51(1):100-3. Epub 2014 Mar 30.
    Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:
    Introduction: We present a developmentally appropriate adolescent boy who presented with upper and lower extremity glove-and-stocking paresthesias, distal weakness, vertigo, high-pitched voice, inattention, ataxia, and binocular diplopia after a voluntary 59-kg weight loss over 5 months.

    Clinical Investigations: Extensive investigations revealed serum thiamine levels <2 nmol/L. Brain magnetic resonance imaging revealed symmetric abnormal T2 prolongation of the mammillary bodies. Read More

    [Thiamine deficiency in infants: a case report].
    Arch Pediatr 2014 Apr 11;21(4):392-5. Epub 2014 Mar 11.
    Service de cardiologie pédiatrique, hôpital des enfants, centre hospitalier universitaire de Purpan, 330, avenue de Grande-Bretagne, 31053 Toulouse cedex, France.
    Thiamine deficiency is recognized in varied parts of the world. In Asia, it remains an important public health problem where highly polished rice is the major staple food and where other primary dietary sources of thiamine are in short supply. Beriberi, or clinically apparent thiamine deficiency, may present a variety of syndromes including myocardial dysfunction or wet beriberi, dry beriberi with neurological symptoms, and the more severe form Shoshin beriberi with cardiac failure and lactic acidosis. Read More

    Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK.
    Neuroscience 2014 May 5;267:102-13. Epub 2014 Mar 5.
    Department of Veterans Affairs Medical Center, Lexington, KY, USA; Department of Molecular and Biochemical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536, USA. Electronic address:
    Obesity and eating disorders are prevailing health concerns worldwide. It is important to understand the regulation of food intake and energy metabolism. Thiamine (vitamin B1) is an essential nutrient. Read More

    Analysis of thiamine transporter genes in sporadic beriberi.
    Nutrition 2014 Apr 19;30(4):485-8. Epub 2013 Oct 19.
    U.O. Neurologia, Fondazione Istituto "San Raffaele-G. Giglio", Cefalù PA, Scilly, Italy. Electronic address:
    Objective: Thiamine or vitamin B1 deficiency diminishes thiamine-dependent enzymatic activity, alters mitochondrial function, impairs oxidative metabolism, and causes selective neuronal death. We analyzed for the first time, the role of all known mutations within three specific thiamine carrier genes, SLC19 A2, SLC19 A3, and SLC25 A19, in a patient with atrophic beriberi, a multiorgan nutritional disease caused by thiamine deficiency.

    Methods: A 44-year-old male alcoholic patient from Morocco developed massive bilateral leg edema, a subacute sensorimotor neuropathy, and incontinence. Read More

    Thiamine deficiency and cardiac dysfunction in Cambodian infants.
    J Pediatr 2014 Jun 5;164(6):1456-61. Epub 2014 Mar 5.
    Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
    Objectives: To compare blood thiamine concentrations, echocardiography findings, and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in infants with clinically diagnosed beriberi and healthy matched controls, and to evaluate changes after thiamine treatment.

    Study Design: Sixty-two Cambodian infants (20 cases and 42 controls), aged 2-47 weeks, were enrolled in this prospective study. Echocardiography and phlebotomy were performed at baseline and after thiamine treatment. Read More

    Total parenteral nutrition caused Wernicke's encephalopathy accompanied by wet beriberi.
    Am J Case Rep 2014 1;15:52-5. Epub 2014 Feb 1.
    Department of Neurology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
    Patient: Female, 17 FINAL DIAGNOSIS: Wernicke's encephalopathy Symptoms: Blurred vision • dizziness • nystygmus • tachycardia

    Medication: - Clinical Procedure: - Specialty: Neurology.

    Objective: Mistake in diagnosis.

    Background: Wernicke's encephalopathy (WE) is an acute and life-threatening illness which is not only seen in alcoholics, but also in persons with poor nutrition lacking thiamine (vitamin B1). Read More

    Acute dilated cardiomyopathy in a patient with beriberi and cryoglobulinaemic vasculitis: an unusual potential complication of two rare disorders.
    Clin Exp Rheumatol 2014 May-Jun;32(3 Suppl 82):S66-9. Epub 2014 Jan 14.
    Vasculitis Research Unit, Department of Autoimmune Diseases. Hospital Clínic of Barcelona. IDIBAPS. University of Barcelona. Barcelona, Spain.
    We report the case of a 45-year-old patient who presented with acute dilated cardiomyopathy. During admission the patient was consecutively diagnosed with cryoglobulinaemic vasculitis and beriberi. In both diseases, cardiac involvement may occur as dilated cardiomyopathy. Read More

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