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    812 results match your criteria Beriberi Thiamine Deficiency

    1 OF 17

    Beriberi Outbreak Among Unauthorised Immigrants in a Detention Camp in Malaysia.
    J Immigr Minor Health 2017 Nov 20. Epub 2017 Nov 20.
    Community and Family Medicine Department, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Jalan UMS, 88300, Kota Kinabalu, Sabah, Malaysia.
    In February 2012, a district health authority received three inmates with bilateral leg swelling and difficulty in breathing from a detention camp for unauthorized immigrants. A case control study was conducted. Fasting blood samples of case and control groups were collected according to instructions of the laboratory for determining thiamine level, and their 1 week dietary intake was analyzed. Read More

    Usefulness of central venous saturation as a predictor of thiamine deficiency in critically ill patients: a case report.
    J Intensive Care 2017 6;5:61. Epub 2017 Nov 6.
    Department of Cardiovascular Medicine, Graduate school of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 1130033 Japan.
    Background: Central venous oxygen saturation (ScvO2) reflects the balance of oxygen delivery and consumption. Low ScvO2 indicates the presence of inadequate oxygen delivery, while high ScvO2 indicates reduced oxygen consumption and is sometimes associated with a high mortality rate in critically ill patients from dysoxia. Thiamine is an essential cofactor in cellular aerobic metabolism. Read More

    Wernicke-Korsakoff syndrome complicated by subacute beriberi neuropathy in an alcoholic patient.
    Clin Neurol Neurosurg 2017 Nov 8;164:1-4. Epub 2017 Nov 8.
    Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, Italy. Electronic address:
    Thiamine (vitamin B1) deficiency is a common condition in alcohol abusers, which can lead to damage of both the peripheral and the central nervous systems. Here we describe the case of an alcoholic patient who presented with acute onset of ataxia, severe weakness of the four limbs, and hypoesthesia and dysesthesia of the distal portion of the upper and lower extremities. The clinical picture also included mental confusion and amnesia. Read More

    A diagnosis and treatment gap for thiamine deficiency disorders in sub-Saharan Africa?
    Ann N Y Acad Sci 2017 Oct 24. Epub 2017 Oct 24.
    Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee.
    Staple diets that are deficient in thiamine can result in low body thiamine levels, which may be subclinical or may manifest as a thiamine-deficiency syndrome. In many communities in the developing countries of Africa, the staple diets of polished rice or processed cassava are deficient in thiamine, and thus the communities are at high risk for marginal or frank thiamine deficiency unless their diets are supplemented by other sources of thiamine, such as protein meals and vegetables. African communities with large numbers of individuals in low socioeconomic strata are more likely to subsist on a monotonous diet of rice or cassava with minimal or no protein supplementation and are therefore particularly at risk of thiamine-deficiency disorders. Read More

    Thiamine content of F-75 therapeutic milk for complicated severe acute malnutrition: time for a change?
    Ann N Y Acad Sci 2017 Sep 14;1404(1):20-26. Epub 2017 Sep 14.
    Pediatric Neurology Unit, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Since community-based management of severe acute malnutrition has become the standard of care, the clinical profile of severe acutely malnourished patients admitted to hospitals or inpatient therapeutic feeding centers has changed significantly. These patients are usually very ill and often present with several comorbidities, such as shock, sepsis, and pneumonia. Complicated severe acute malnutrition patients are at risk of thiamine insufficiency, and critically ill patients have higher thiamine requirements. Read More

    High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children.
    PLoS Negl Trop Dis 2017 Sep 5;11(9):e0005814. Epub 2017 Sep 5.
    Institute of Research for Development (IRD), UMR-204, IRD-UM-SupAgro, Montpellier, France.
    Background: Thiamine deficiency is thought to be an issue in Cambodia and throughout Southeast Asia due to frequent clinical reports of infantile beriberi. However the extent of this public health issue is currently unknown due to a lack of population-representative data. Therefore we assessed the thiamine status (measured as erythrocyte thiamine diphosphate concentrations; eThDP) among a representative sample of Cambodian women of childbearing age (15-49 y) and their young children (6-69 mo). Read More

    Nonalcoholic Wernicke's Encephalopathy: A Retrospective Study from a Tertiary Care Center in Northern India.
    J Neurosci Rural Pract 2017 Jul-Sep;8(3):401-406
    Department of Food Sciences and Technology, University of Kashmir, Srinagar, Jammu and Kashmir, India.
    Objective: The objective of this study was to describe the demographic features, clinical presentation, and management and outcome of fifty cases of nonalcoholic Wernicke's encephalopathy from a tertiary care hospital of a region with reported incidence of thiamine deficiency disorders.

    Materials And Methods: In a retrospective study, fifty adult cases of Wernicke's encephalopathy were analyzed. The diagnosis of Wernicke's encephalopathy was made according to the European federation of neurological societies guidelines 2010. Read More

    Wernicke's encephalopathy in exclusive breastfed infants.
    World J Pediatr 2017 Oct 24;13(5):485-488. Epub 2017 May 24.
    Department of Pediatrics, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India.
    Background: Kashmir has a population that largely consumes polished rice which is deficient in thiamine. Furthermore, lactating women in this region are prone to severe thiamine deficiency because of their traditional food avoidance practices. Infantile beriberi is common in exclusively breastfed infants of thiamine deficient mothers in Kashmir. Read More

    A Large Outbreak of Thiamine Deficiency Among Illegal Gold Miners in French Guiana.
    Am J Trop Med Hyg 2017 05;96(5):1248-1252
    Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane, Cayenne, French Guiana, France.
    From September 2013 to July 2014, several gold miners working in the tropical forest consulted the Maripasoula Health Center in French Guiana for edema and findings consistent with right-sided cardiac failure. Of the 42 cases of beriberi that were diagnosed, one patient died. The laboratory and clinical investigation demonstrated vitamin B1 deficiency in most of the patients tested. Read More

    No Camphor Toxicity in Cambodian Infants.
    Glob Pediatr Health 2017 24;4:2333794X17702980. Epub 2017 Apr 24.
    Mayo Clinic, Rochester, MN, USA.
    Thiamine deficiency and beriberi are prevalent in Cambodia, although most infants with nonspecific clinical symptoms of beriberi, including tachypnea, lack echocardiographic evidence diagnostic of the disease. Camphor activates transient receptor potential vanilloid 3 (TRPV3), a nonselective ion channel expressed in the medial preoptic nucleus of the hypothalamus and thought to be important for thermo-sensitivity. Because camphorated ointments are used commonly among Cambodian infants, we hypothesized that topical camphor modulates thermoregulatory behaviors, causing beriberi-simulating tachypnea, separate from any influence of thiamine deficiency. Read More

    Thiamine Assays-Advances, Challenges, and Caveats.
    ChemistryOpen 2017 Apr 8;6(2):178-191. Epub 2017 Mar 8.
    Department of Natural ResourcesCornell UniversityIthacaNY14853USA.
    Thiamine (vitamin B1) is essential to the health of all living organisms and deficiency has long been associated with diseases in animals such as fish, birds, alligators, and domesticated ruminant mammals. Thiamine is also implicated in several human diseases including Alzheimer's, diabetes, dementia, depression and, most notably, Wernicke-Korsakoff syndrome and Beriberi disease. Yet, highly sensitive and specific detection of thiamine remains an analytical challenge, as pM to nm levels of thiamine need to be detected in environmental and human samples, respectively, various phosphorylated variants need to be discriminated, and rapid on-site detection would be highly desirable. Read More

    [Wernicke encephalopathy and dry beriberi; late complications after bariatric surgery performed on a patient with a psychiatric history].
    Tijdschr Psychiatr 2017 ;59(2):116-120
    A 38-year-old woman was admitted in a psychiatric hospital because of memory disorders. Dry beriberi and Korsakoff's syndrome, as a late neuropsychiatric manifestation of Wernicke's encephalopathy, were established. The beriberi symptoms decreased slowly, but the patient's memory impairments persisted. Read More

    Shoshin beriberi-thiamine responsive pulmonary hypertension in exclusively breastfed infants: A study from northern India.
    Indian Heart J 2017 Jan - Feb;69(1):24-27. Epub 2016 Aug 2.
    Department of Pediatrics, SKIMS Srinagar, J&K, India. Electronic address:
    Objective: To study the effect of thiamine administration on the resolution of pulmonary hypertension in exclusively breastfed infants.

    Design: Prospective cohort study.

    Setting: Hospital based study of a tertiary care hospital. Read More

    Prevalence of clinical thiamine deficiency in individuals with medically complicated obesity.
    Nutr Res 2017 Jan 1;37:29-36. Epub 2016 Dec 1.
    Center for Advanced Laparoscopic General & Bariatric Surgery, MedStar-Washington Hospital Center and Georgetown University School of Medicine, Washington, DC 20010, USA. Electronic address:
    Thiamine is a vitamin whose deficient can result in multiorgan symptoms. We described an 18% prevalence of clinical thiamine deficiency after gastric bypass surgery. Our hypotheses are that individuals with medically complicated obesity frequently have clinical thiamine deficiency and that diabetes mellitus is a mechanism for development of clinical thiamine deficiency. Read More

    Thiamine Deprivation Produces a Liver ATP Deficit and Metabolic and Genomic Effects in Mice: Findings Are Parallel to Those of Biotin Deficiency and Have Implications for Energy Disorders.
    J Nutrigenet Nutrigenomics 2016 18;9(5-6):287-299. Epub 2017 Feb 18.
    Unidad de Genética de la Nutrición, Instituto de Investigaciones Biomédicas UNAM - Instituto Nacional de Pediatría, Mexico City, Mexico.
    Thiamine is one of several essential cofactors for ATP generation. Its deficiency, like in beriberi and in the Wernicke-Korsakoff syndrome, has been studied for many decades. However, its mechanism of action is still not completely understood at the cellular and molecular levels. Read More

    Beriberi Induced Cardiomyopathy Requiring Salvage Venoarterial Extracorporeal Membrane Oxygenation.
    Case Rep Crit Care 2016 5;2016:5043818. Epub 2016 Dec 5.
    Advocate Christ Medical Center, Oak Lawn, IL, USA.
    Beriberi refers to a constellation of symptoms caused primarily by thiamine (vitamin B1) deficiency. An acute and fulminant presentation of this rare condition has been described in the literature as "Shoshin" beriberi which is characterized by catastrophic cardiovascular collapse. Early recognition and treatment lead to dramatic improvements of symptoms. Read More

    [Beriberi 10 years after gastric bypass surgery - case report].
    Laeknabladid 2016 Nov;102(11):497-499
    Beriberi is primarily related to malnutrition, but also known as a complication following abdominal surgical procedures. A 41 year old woman, who underwent gastric bypass surgery 10 years earlier, presented at the emergency department of Landspitali with general weakness and paresthesia. Physical examination revealed muscle atrophy and attenuated deep tendon reflexes in her lower limbs; presenting as polyneuropathy due to beriberi. Read More

    Perinatal Consumption of Thiamine-Fortified Fish Sauce in Rural Cambodia: A Randomized Clinical Trial.
    JAMA Pediatr 2016 Oct 3;170(10):e162065. Epub 2016 Oct 3.
    Food, Nutrition, and Health, University of British Columbia, Vancouver, British Columbia, Canada9South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia10Discipline of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia.
    Importance: Infantile beriberi, a potentially fatal disease caused by thiamine deficiency, remains a public health concern in Cambodia and regions where thiamine-poor white rice is a staple food. Low maternal thiamine intake reduces breast milk thiamine concentrations, placing breastfed infants at risk of beriberi.

    Objective: To determine if consumption of thiamine-fortified fish sauce yields higher erythrocyte thiamine diphosphate concentrations (eTDP) among lactating women and newborn infants and higher breast milk thiamine concentrations compared with a control sauce. Read More

    An unusual case of cardiogenic shock in which thiamine administration led to reversal of lactic acidosis and heart function recovery: Shoshin beriberi in an adolescent.
    Int J Cardiol 2016 Nov 30;222:401-3. Epub 2016 Jul 30.
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.

    Thiamine Deficiency in Tropical Pediatrics: New Insights into a Neglected but Vital Metabolic Challenge.
    Front Nutr 2016 14;3:16. Epub 2016 Jun 14.
    Pediatric Team, Medical Department, Médecins Sans Frontières (MSF) , Barcelona , Spain.
    In humans, thiamine is a micronutrient prone to depletion that may result in severe clinical abnormalities. This narrative review summarizes current knowledge on thiamine deficiency (TD) and bridges the gap between pathophysiology and clinical presentation by integrating thiamine metabolism at subcellular level with its function to vital organs. The broad clinical spectrum of TD is outlined, with emphasis on conditions encountered in tropical pediatric practice. Read More

    Acute Abdominal Pain as a Presenting Symptom of Beriberi in a Pediatric Patient.
    J Trop Pediatr 2016 12 20;62(6):490-495. Epub 2016 Jun 20.
    Departamento de Pediatria, Faculdade de Ciências Médicas, Universidade Estadual de Campinas - UNICAMP - São Paulo, CP 6109, Brazil
    Vitamin B1 (thiamine) plays a fundamental role in the proper functioning of the nervous and cardiovascular systems and in glucose metabolism. Because of the inability of the human body to store large amounts of vitamin, continuous restoration through diet is necessary. In the pediatric population, thiamine deficiency has a broad spectrum of clinical presentations, making diagnosis difficult. Read More

    The influence of infantile thiamine deficiency on primary dentition.
    Clin Oral Investig 2017 May 17;21(4):1309-1313. Epub 2016 Jun 17.
    Pediatric Dental Unit, Barzilai Medical Center, Ashkelon, Israel.
    Objectives: The present study explored the histological and chemical effects of infantile thiamine deficiency (ITD) on enamel development through the examination of exfoliated deciduous teeth from a patient who had been fed during his first year of life with a thiamine-deficient milk substitute.

    Materials And Methods: Ground sections derived from six exfoliated primary teeth were examined. Slices from a light microscope were photographed for histological analysis. Read More

    [Clinical appearance and scalable profile Thiamine deficiency in prison in Guinea: study of thirty-eight observations].
    Bull Soc Pathol Exot 2016 May 29;109(2):70-6. Epub 2016 Mar 29.
    CHU, Conakry, Guinée.
    Cardiovascular and neurological manifestations associated with thiamine deficiency in Guinean prisons are common but not reported.We performed a prospective study of 38 cases related to vitamin B1 deficiency over a period of 4 years. In this population, the literature of traditional data gathered: frequency peak after thirty (92. Read More

    Case report: pericardial effusion with constrictive physiology in a patient with wet beriberi.
    Nutr J 2016 Apr 8;15:37. Epub 2016 Apr 8.
    Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa, University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
    Wet beriberi-induced pericardial effusion has rarely been previously described. Little is known about the effect of beriberi-induced pericardial effusion on hemodynamics. Here we present a case of wet beriberi with pericardial effusion that exhibited constrictive physiology, which was dramatically improved after treatment. Read More

    Thiamine deficiency in tachypnoeic Cambodian infants.
    Paediatr Int Child Health 2015 ;35(4):312-8
    Mayo Medical School.
    Background: Beriberi is endemic in South-east Asia. Diagnosis is based on clinical findings, but correlation of clinical features with blood thiamine concentrations is uncertain.

    Objectives: To investigate in tachypnoeic Cambodian infants the correlation between whole blood thiamine diphosphate (TDP) concentrations, clinical findings and blood TDP levels after therapy. Read More

    Wernicke's Encephalopathy, Wet Beriberi, and Polyneuropathy in a Patient with Folate and Thiamine Deficiency Related to Gastric Phytobezoar.
    Case Rep Neurol Med 2015 30;2015:624807. Epub 2015 Nov 30.
    Severo Ochoa Hospital, Leganés, 28911 Madrid, Spain.
    Background. Wernicke's encephalopathy (WE) is an acute neurological disorder resulting from thiamine deficiency. It is mainly related to alcohol abuse but it can be associated with other conditions such as gastrointestinal disorders. Read More

    High-Output Heart Failure Caused by Thyrotoxicosis and Beriberi.
    Crit Care Nurs Clin North Am 2015 Dec 2;27(4):499-510. Epub 2015 Sep 2.
    Sutter Medical Center, 2801 L Street, Sacramento, CA 95816, USA. Electronic address:
    High-output heart failure is not seen as commonly as low-output heart failure and some of the typical guideline recommendations may not benefit patients with high-output failure. High-output failure is caused by several diseases, including thyrotoxicosis and beriberi, highlighted in this article. Thyrotoxicosis, caused by excessive thyroid hormone production, has profound hemodynamic effects. Read More

    Dry beriberi preceded Wernicke's encephalopathy: Thiamine deficiency after laparoscopic sleeve gastrectomy.
    J Pediatr Neurosci 2015 Jul-Sep;10(3):297-9
    Division of Child Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
    In recent times, pediatric obesity has become widely prevalent. If first-line treatment with lifestyle modification fails, bariatric surgery may be indicated for severely obese patients. Many patients now travel abroad to get these surgeries done. Read More

    Thiamine responsive acute life threatening metabolic acidosis in exclusively breast-fed infants.
    Nutrition 2016 Feb 2;32(2):213-6. Epub 2015 Sep 2.
    GMC Srinagar, GB Pant Hospital, Department of Pediatrics, Kashmir, India.
    Background: Acute life threatening metabolic acidosis in exclusively breast fed infants due to thiamine deficiency is not described. Kashmir valley, a north Indian state has a population that largely consumes polished rice.

    Methods: A six months prospective descriptive study of infants who presented with acute life threatening metabolic acidosis (Blood pH ≤ 7. Read More

    [An Uncommon Diagnosis].
    Praxis (Bern 1994) 2015 Oct;104(21):1151-6
    1 Universitätsklinik für Endokrinologie, Diabetologie und Klinische Ernährung, Inselspital Bern.
    We report on a 61-year-old patient who suffered from severe protein-energy malnutrition due to an inadequately treated exocrine pancreatic insufficiency. In this context, a thiamine deficiency was not recognized and there were clinical manifestations of beriberi disease with decompensated biventricular heart failure. In the course of time, a manifest niacin deficiency (pellagra) with dermatitis, diarrhea and persistent delirium occurred, which was recognized and could be treated. Read More

    Sudden infant death syndrome and abnormal metabolism of thiamin.
    Med Hypotheses 2015 Dec 14;85(6):922-6. Epub 2015 Sep 14.
    Associate Emeritus, Cleveland Clinic Foundation, Cleveland, OH, United States. Electronic address:
    Although it has been generally accepted that moving the infant from the prone to the supine position has solved the problem of sudden infant death syndrome (SIDS), it has been hypothesized that this is an insufficient explanation and that a mixture of genetic risk, some form of stressful incident and marginal brain metabolism is proportionately required. It is suggested that each of these three variables, with dominance in one or more of them, act together in the common etiology. Much has been written about the association of thiamin and magnesium but the finding of extremely high concentrations of serum thiamin in SIDs victims has largely caused rejection of thiamin as being involved in the etiology. Read More

    Enhancement of Thiamin Content in Arabidopsis thaliana by Metabolic Engineering.
    Plant Cell Physiol 2015 Dec 9;56(12):2285-96. Epub 2015 Oct 9.
    Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97330, USA Hermiston Agricultural Research and Extension Center, Oregon State University, 2121 S First Street, Hermiston, OR 97838, USA
    Thiamin is an essential nutrient in the human diet. Severe thiamin deficiency leads to beriberi, a lethal disease which is common in developing countries. Thiamin biofortification of staple food crops is a possible strategy to alleviate thiamin deficiency-related diseases. Read More

    Shoshin Beriberi With Low Cardiac Output and Hemodynamic Deterioration Treated Dramatically by Thiamine Administration.
    Int Heart J 2015 4;56(5):568-70. Epub 2015 Sep 4.
    Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, The University of Tokyo.
    "Shoshin beriberi", which is a fulminant form of cardiovascular beriberi accompanied by hemodynamic deterioration with high cardiac output and decreased systemic blood pressure, caused by thiamine deficiency due to alcoholic abuse or malnutrition, is often difficult to address because of its rarity and non-specific symptoms. We here present a patient with a history of alcoholic abuse who had suffered hemodynamic deterioration with extremely low cardiac output refractory to extracorporeal membrane oxygenation and intravenous catecholamine support, which was improved dramatically by bolus intravenous thiamine administration. Such a type with low cardiac output would be the most severe form of Shoshin beriberi, and cannot be rescued without diagnostic administration of thiamine. Read More

    Infantile encephalitic beriberi: magnetic resonance imaging findings.
    Pediatr Radiol 2016 Jan 19;46(1):96-103. Epub 2015 Aug 19.
    Department of Pediatrics, Government Medical College Srinagar, Jammu and Kashmir, India.
    Background: Thiamine deficiency in infants is still encountered in developing countries. It may present with acute neurological manifestations of infantile encephalitic beriberi.

    Objective: To review brain MRI findings in infantile encephalitic beriberi from a single institution. Read More

    The Japanese Hospital in Broome, 1910-1926. A harmony of contrasts.
    J R Coll Physicians Edinb 2015 ;45(2):156-64
    P Stride, University of Queensland School of Medicine, Brisbane, Queensland 4012, Australia. Email
    The Japanese Hospital in Broome remains the only hospital in Australia's history predominantly staffed, controlled and funded by a linguistically, culturally and geographically alien nation. Initially the proposal, challenging prevailing attitudes, was bitterly opposed by the white community, but the hospital became respected thanks to Dr Tadashi Suzuki, the hospital's first doctor, and his successors' clinical skills and compassion. Read More

    [Experimental Approach to Analysis of the Relationship between Food Environments and Lifestyle-Related Diseases, Including Cardiac Hypertrophy, Fatty Liver, and Fatigue Symptoms].
    Nihon Eiseigaku Zasshi 2015 ;70(2):110-4
    Department of Hygiene and Health Promotion Medicine, Kagoshima University Graduate School of Medical and Dental Sciences.
    The food habit is involved in the onset and development of lifestyle-related diseases. In this review I would like to describe a historical case of vitamin B1 deficiency, as well as our case study of fatty acid metabolism abnormality due to carnitine deficiency. In history, the army and navy personnel in Japan at the end of the 19th century received food rations based on a high-carbohydrate diet including white rice, resulting in the onset of beriberi. Read More

    Shoshin Beriberi in Critically-Ill patients: case series.
    Nutr J 2015 May 17;14:51. Epub 2015 May 17.
    Department of Medicine, Kidney and Dialysis Research Laboratory, Division of Nephrology, St. Elizabeth's Medical Center, 736 Cambridge Street, 02135, Boston, MA, USA.
    Thiamine plays a fundamental role in cellular metabolism. The classical syndrome caused by thiamine deficiency is beriberi, and its fulminant variant, once considered an uncommon finding, is now encountered among the critically ill.We present a case series of four critically ill non-septic non-alcoholic patients with severe lactic acidosis and refractory cardio-circulatory collapse caused by acute fulminant beriberi, which drastically responded to thiamine administration. Read More

    Elevated Lactate Secondary to Gastrointestinal Beriberi.
    J Gen Intern Med 2016 Jan 16;31(1):133-6. Epub 2015 Apr 16.
    The Queen's Medical Center, 1301 Punchbowl St., Honolulu, 96813, HI, USA.
    Thiamine deficiency usually occurs with prolonged nutritional deficiency and is almost universally identified with Wernicke's encephalopathy or beriberi. It is also, however, a rare cause of elevated lactate and gastroenterological symptoms. This case report describes a 30-year-old man with 2 weeks of gastroenterological symptoms and intermittent oral intake, who was found to have an elevated lactate level. Read More

    Beriberi (thiamine deficiency) and high infant mortality in northern Laos.
    PLoS Negl Trop Dis 2015 Mar 17;9(3):e0003581. Epub 2015 Mar 17.
    Institut de la Francophonie pour la Médecine Tropicale, Vientiane, Lao, PDR.
    Background: Infantile beriberi (thiamine deficiency) occurs mainly in infants breastfed by mothers with inadequate intake of thiamine, typically among vulnerable populations. We describe possible and probable cases of infantile thiamine deficiency in northern Laos.

    Methodology/principal Findings: Three surveys were conducted in Luang Namtha Province. Read More

    Poor thiamin and riboflavin status is common among women of childbearing age in rural and urban Cambodia.
    J Nutr 2015 Mar 7;145(3):628-33. Epub 2015 Jan 7.
    Food, Nutrition, and Health and
    Background: Thiamin deficiency in infancy is the underlying cause of beriberi, which can be fatal without rapid treatment. Reports of thiamin deficiency are common in Cambodia; however, population representative data are unavailable. Because B-complex vitamin deficiencies commonly occur in combination, riboflavin was also investigated. Read More

    Clinicopathologic features of folate-deficiency neuropathy.
    Neurology 2015 Mar 6;84(10):1026-33. Epub 2015 Feb 6.
    From the Department of Neurology (H.K., M.T., K.O., R.H., Y.K., M.I., M.K., G.S.), Nagoya University Graduate School of Medicine; and Department of Neurology and Stroke Medicine (H.D., F.T.), Yokohama City University Graduate School of Medicine, Japan.
    Objective: The clinical significance and characteristics of neuropathy caused by folate deficiency remain to be established.

    Methods: We examined the clinicopathologic features of 18 consecutive patients with neuropathy caused by folate deficiency who presented with low serum folate levels but normal blood thiamine and serum cobalamin levels in the absence of chronic alcoholism.

    Results: Symptoms were relatively uniform, characterized by slowly progressive polyneuropathy with predominant involvement of the lower extremities, with a tendency to manifest as sensory rather than motor neuropathy and predominant deep rather than superficial sensory loss. Read More

    A case of shoshin beriberi presenting as cardiogenic shock with diffuse ST-segment elevation, which dramatically improved after a single dose of thiamine.
    Cardiovasc J Afr 2014 Nov 23;25(6):e1-5. Epub 2014 Nov 23.
    Department of Internal Medicine, Konkuk University Hospital, School of Medicine, Konkuk University, Seoul, Korea.
    Shoshin beriberi is a fulminant form of cardiac beriberi caused by thiamine deficiency. We report on a case of an 87-year-old man with shoshin beriberi presenting as cardiogenic shock with diffuse ST-segment elevation, which dramatically improved after thiamine administration. Because of the rarity of the occurrence, lack of diagnostic test and atypical presentation, diagnosing shoshin beriberi is challenging and requires a high index of clinical suspicion. Read More

    Thiamine Deficiency in a Developed Country: Acute Lactic Acidosis in Two Neonates Due to Unsupplemented Parenteral Nutrition.
    JPEN J Parenter Enteral Nutr 2016 Aug 15;40(6):886-9. Epub 2015 Jan 15.
    Department of Neonatology, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
    Thiamine is a water-soluble vitamin implicated in several metabolic processes. Its deficiency, due to prolonged parenteral nutrition without adequate vitamin supplementation, can lead to multiorgan failure characterized by cardiovascular impairment and metabolic acidosis refractory to bicarbonate administration. Only thiamine administration allows the remission of symptoms. Read More

    Thiamine and magnesium deficiencies: keys to disease.
    Med Hypotheses 2015 Feb 15;84(2):129-34. Epub 2014 Dec 15.
    Associate Emeritus, Cleveland Clinic, Cleveland, OH, United States. Electronic address:
    Thiamine deficiency (TD) is accepted as the cause of beriberi because of its action in the metabolism of simple carbohydrates, mainly as the rate limiting cofactor for the dehydrogenases of pyruvate and alpha-ketoglutarate, both being critical to the action of the citric acid cycle. Transketolase, dependent on thiamine and magnesium, occurs twice in the oxidative pentose pathway, important in production of reducing equivalents. Thiamine is also a cofactor in the dehydrogenase complex in the degradation of the branched chain amino acids, leucine, isoleucine and valine. Read More

    Thiamine deficiency in tachypnoeic Cambodian infants.
    Paediatr Int Child Health 2014 Oct 27:2046905514Y0000000162. Epub 2014 Oct 27.
    Background: Beriberi is endemic in South-east Asia. Diagnosis is based on clinical findings, but correlation of clinical features with blood thiamine concentrations is uncertain. Objectives: To investigate in tachypnoeic Cambodian infants the correlation between whole blood thiamine diphosphate (TDP) concentrations, clinical findings and blood TDP levels after therapy. Read More

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