3,455 results match your criteria Benign and Malignant Soft Tissue Tumors


Core Needle Biopsy versus Fine Needle Aspiration Cytology in Bone and Soft Tissue Tumors.

Authors:
Bharat Rekhi

J Cytol 2019 Apr-Jun;36(2):118-123

Department of Surgical Pathology, Tata Memorial Centre, Parel, Mumbai, Maharashtra, India.

Fine needle aspiration cytology (FNAC) for diagnosis of musculoskeletal tumors is well discussed and debated. The current evidence restricts its application in recurrent and metastatic lesions, with core needle biopsy as the acceptable technique/gold standard for the primary diagnosis of these challenging tumors. However, there are several studies showing reasonable sensitivity and specificity in primary diagnosis of bone and soft tissue tumors, especially in differentiating benign from malignant tumors. Read More

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http://www.jcytol.org/text.asp?2019/36/2/118/253726
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http://dx.doi.org/10.4103/JOC.JOC_125_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425772PMC
April 2019
1 Read

Distribution and evaluation of bone and soft tissue tumors operated in a tertiary care center.

Acta Orthop Traumatol Turc 2019 Apr 11. Epub 2019 Apr 11.

Department of Orthopaedics and Traumatology, Dr Abdurrahan Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.

Objective: The aim of this study was to retrospectively evaluate the patients who were operated in our orthopedics and traumatology clinic with the suspection of bone and soft tissue tumors.

Methods: A total of 3133 patients (1146 (46.5%) female and 1318 (53. Read More

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http://dx.doi.org/10.1016/j.aott.2019.03.008DOI Listing
April 2019
1 Read

Intraluminal capillary hemangioma of the foot presenting clinically as a neuroma: A case report.

Foot (Edinb) 2019 Apr 6;39:76-78. Epub 2019 Apr 6.

Resident Physician, Department of Podiatric Medicine & Surgery, East Liverpool City Hospital, 425 W 5th St, East Liverpool, OH 43920, USA. Electronic address:

Capillary hemangiomas are rarely seen in the foot, especially in the deeper soft tissue compartment. If left untreated, they can give rise to benign soft-tissue tumors. A rare case of a capillary hemangioma on the right dorsal medial midfoot that, because of its location adjacent to the saphenous nerve, mimicked the signs and symptoms of a neuroma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09582592193001
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http://dx.doi.org/10.1016/j.foot.2019.03.011DOI Listing
April 2019
2 Reads

Leiomyoma of the External Auditory Canal.

J Int Adv Otol 2019 Mar 29. Epub 2019 Mar 29.

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.

Angioleiomyomas (ALMAs) are benign tumors that arise from smooth muscle cells that form the tunica media of vascular structures. To our knowledge, only five cases of ALMA of the external auditory canal (EAC) have been reported. We report the case of a 52-year-old man with left otalgia, otorrhea, auricular fullness, and hearing loss. Read More

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http://dx.doi.org/10.5152/iao.2019.4743DOI Listing
March 2019
1 Read

Dermatofibrosarcoma protuberans: clinicopathologic presentation in Nigerians.

Pan Afr Med J 2018 12;31:25. Epub 2018 Sep 12.

Department of Oral and Maxillofacial Surgery, College of Medicine University of Lagos, Nigeria.

Introduction: Dermatofibrosarcoma protuberance (DFSP) is in general a rare low grade malignant sarcoma and possesses a tendency for local recurrence. It has a site predilection for the trunk. Occurrence in the facial area is extremely rare. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.25.13665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430858PMC
April 2019
1 Read

Small soft tissue masses indeterminate at imaging: histological diagnoses at a tertiary orthopedic oncology clinic.

Skeletal Radiol 2019 Mar 22. Epub 2019 Mar 22.

Department of Radiology, University of Miami Miller School of Medicine/Jackson Memorial Hospital, 1611 NW 12th Ave, JMH WW 279, Miami, FL, 33136, USA.

Objective: To review histologic diagnoses of soft-tissue masses (STMs) ≤ 2 cm with indeterminate imaging features encountered in musculoskeletal oncology clinic at a tertiary referral center.

Materials And Methods: This was an IRB-approved retrospective review of patients with STMs ≤ 2 cm, referred to our tertiary care orthopedic oncology clinic over 4.75 consecutive years. Read More

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http://link.springer.com/10.1007/s00256-019-03205-0
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http://dx.doi.org/10.1007/s00256-019-03205-0DOI Listing
March 2019
7 Reads

Retroperitoneal Tumor: A Silent Trespasser - Role of Image-Guided Fine-Needle Aspiration Cytology with Histopathological Correlation in Early Diagnosis.

Acta Cytol 2019 Mar 20:1-9. Epub 2019 Mar 20.

Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Raipur, India.

Objective: Retroperitoneal lesions present a great diagnostic challenge. Here we analyze the spectrum of retroperitoneal lesions and the utility of cytohistopathological correlation in early diagnosis.

Study Design: This 7-year study was undertaken in 338 patients with a retroperitoneal mass (kidney/adrenal/ pancreas/retroperitoneal lymph node, or soft tissue origin). Read More

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http://dx.doi.org/10.1159/000497077DOI Listing
March 2019
5 Reads
1.562 Impact Factor

Canine Spindle Cell Mammary Tumor: A Retrospective Study of 67 Cases.

Vet Pathol 2019 Mar 11:300985819829522. Epub 2019 Mar 11.

1 Department Animal Medicine, Surgery and Pathology, Veterinary Medicine School, Complutense University of Madrid (UCM), Madrid, Spain.

Canine spindle cell mammary tumor (CSCMT) is an infrequent canine mammary tumor (CMT) composed of spindle or fusiform cells, which represents a challenge for pathologists and clinicians. Mammary tumors submitted for histopathology from 1998 to 2013 and compatible with CSCMTs were retrospectively selected. The tumors were diagnosed based on the hematoxylin and eosin (HE)-stained section; malignant tumors were graded using a canine soft tissue sarcoma grading scheme and a canine mammary tumor grading scheme, and they were further assigned a diagnosis based on immunohistochemistry (IHC) for pancytokeratin, cytokeratin 14, p63, calponin, vimentin, Ki-67, CD31, desmin, myosin, smooth muscle actin, glial fibrillary acidic protein, and S-100. Read More

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http://dx.doi.org/10.1177/0300985819829522DOI Listing
March 2019
3 Reads

Langerhans cell sarcoma arising from antecedent langerhans cell histiocytosis: A case report.

Medicine (Baltimore) 2019 Mar;98(10):e14531

Department of Nephrology, Zhejiang Provincial People's Hospital, People's Hospital Of Hangzhou Medical College, Hangzhou, China.

Rationale: Langerhans cell sarcoma (LCS) is a rare, high-grade neoplasm characterized by overtly malignant cytologic features and a poor prognosis. Herein, we present a rare case of langerhans cell histiocytosis (LCH) that later transformed into langerhans cell sarcoma 11 months after the benign mass was excised from soft tissue in the right groin.

Patient Concerns: A 41-year-old patient who presented with a mass in the right groin for 3 years earlier after being bitten by ants. Read More

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http://dx.doi.org/10.1097/MD.0000000000014531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417513PMC
March 2019
4 Reads

A contemporary review of myxoid adipocytic tumors.

Authors:
David Creytens

Semin Diagn Pathol 2019 Mar 28;36(2):129-141. Epub 2019 Feb 28.

Department of Pathology, Ghent University and Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent University and Ghent University Hospital, Ghent, Belgium. Electronic address:

Myxoid adipocytic tumors encompass a broad heterogeneous group of benign and malignant adipocytic tumors, which are typically myxoid (e.g. myxoid liposarcoma, lipoblastoma and lipoblastoma-like tumor of the vulva) or may occasionally appear predominantly myxoid (e. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.02.008DOI Listing
March 2019
1 Read

More advantages in detecting bone and soft tissue metastases from prostate cancer using F-PSMA PET/CT.

Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7.

Department of Nuclear Medicine and PET/CT, Evangelismos General Hospital, Ypsilantou 45-47, PC 106 76, Athens, Greece.

Prostate cancer (PCa) is the most common solid cancer affecting men worldwide. Serum prostate-specific antigen (PSA) is at present the most commonly used biomarker for PCa screening, as well as a reliable marker of disease recurrence after initial treatment. Bone metastases (BM) are present in advanced stages of the disease. Read More

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http://dx.doi.org/10.1967/s002449910952DOI Listing
March 2019
9 Reads

Do Early Results of Proximal Humeral Allograft-Prosthetic Composite Reconstructions Persist at 5-year Followup?

Clin Orthop Relat Res 2019 Apr;477(4):758-765

M. El Beaino, V. O. Lewis, P. P. Lin, Department of Orthopaedic Oncology, MD Anderson Cancer Center, Houston, TX, USA J. Liu, Department of Bone and Soft Tissue Tumor, Peking University Cancer Hospital, Beijing, China.

Background: Insufficiency of the rotator cuff is a major problem after resections of proximal humeral tumors and can limit shoulder motion despite preservation of the deltoid muscle and axillary nerve. Allograft-prosthetic composite reconstruction offers one method to reattach the rotator cuff tendons and has been successful in small studies with short followup. However, data are lacking with regard to implant durability, changes in Musculoskeletal Tumor Society (MSTS) scores over time, and delayed complications with extended followup. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000354DOI Listing
April 2019
1 Read

Magnetic Resonance-Guided Focused Ultrasound: A Brief Review With Emphasis on the Treatment of Extra-abdominal Desmoid Tumors.

Ultrasound Q 2019 Feb 20. Epub 2019 Feb 20.

Vascular and Interventional Radiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, WI.

Magnetic resonance-guided focused ultrasound (MRgFUS) utilizes high-intensity focused ultrasound to noninvasively, thermally ablate lesions within the body while sparing the intervening tissues. Magnetic resonance imaging provides treatment planning and guidance, and real-time magnetic resonance thermometry provides continuous monitoring during therapy. Magnetic resonance-guided focused ultrasound is ideally suited for the treatment of extra-abdominal desmoid fibromatosis due to its noninvasiveness, lack of ionizing radiation, low morbidity, and good safety profile. Read More

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http://dx.doi.org/10.1097/RUQ.0000000000000431DOI Listing
February 2019
2 Reads

Does Denosumab Change the Giant Cell Tumor Treatment Strategy? Lessons Learned From Early Experience.

Clin Orthop Relat Res 2018 Sep;476(9):1773-1782

M. G. Agarwal, M. K. Gundavda, R. Reddy, Orthopedic Oncology, PD Hinduja Hospital and Medical Research Center, Mumbai, India R. Gupta, Orthopedic Oncology, Fortis Hospital Mohali, India.

Background: Although giant cell tumors (GCTs) are benign, their aggressiveness and tendency to recur locally challenge the orthopaedic surgeon's ability to perform joint-preserving intralesional surgery with an acceptably low risk of local recurrence. Denosumab has emerged as a possible medical treatment of GCT because it seems to halt the progression of GCT, alleviate pain, and increase perilesional bone formation, but its exact role has been questioned, and specifically its efficacy and associated complications are not well characterized.

Questions/purposes: (1) Does denosumab reduce the risk of recurrence after resection or intralesional surgery? (2) What are the complications associated with the use of denosumab?

Methods: Fifty-four patients with 30 primary and 25 recurrent tumors between November 2013 and July 2016 were treated with denosumab after a confirmed histopathologic diagnosis of GCT. Read More

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http://dx.doi.org/10.1007/s11999.0000000000000243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259809PMC
September 2018
6 Reads

Magnetic resonance imaging biomarkers in musculoskeletal soft tissue tumors: Review of conventional features and focus on nonmorphologic imaging.

J Magn Reson Imaging 2019 Feb 21. Epub 2019 Feb 21.

The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

The majority of peripheral musculoskeletal soft tissue masses encountered in routine clinical practice are benign and associated with an excellent prognosis, whereas a small proportion of soft tissue masses are malignant and are associated with higher morbidity and mortality. Owing to the excellent tissue contrast resolution provided, magnetic resonance imaging (MRI) is a primary modality for the diagnostic evaluation of soft tissue masses, particularly for defining the anatomic extent. MRI is also useful for the characterization of soft tissue masses; however, after the exclusion of cysts and lipomas, it is challenging to accurately categorize neoplastic lesions as benign or malignant with conventional anatomic MRI. Read More

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http://dx.doi.org/10.1002/jmri.26659DOI Listing
February 2019
1 Read

Detection of Circulating Tumor DNA in Patients With Leiomyosarcoma With Progressive Disease.

JCO Precis Oncol 2019 24;2019. Epub 2019 Jan 24.

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.

Purpose: Leiomyosarcoma (LMS) is a soft tissue sarcoma characterized by multiple copy number alterations (CNAs) and without common recurrent single nucleotide variants. We evaluated the feasibility of detecting circulating tumor DNA (ctDNA) with next-generation sequencing in a cohort of patients with LMS whose tumor burden ranged from no evidence of disease to metastatic progressive disease.

Patients And Methods: Cell-free DNA in plasma samples and paired genomic DNA from resected tumors were evaluated from patients with LMS by ultra-low passage whole genome sequencing (ULP-WGS). Read More

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http://dx.doi.org/10.1200/PO.18.00235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380497PMC
January 2019
1 Read

Identification of novel GNAS mutations in intramuscular myxoma using next-generation sequencing with single-molecule tagged molecular inversion probes.

Diagn Pathol 2019 Feb 8;14(1):15. Epub 2019 Feb 8.

Department of Pathology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands.

Background: Intramuscular myxoma (IM) is a hypocellular benign soft tissue neoplasm characterized by abundant myxoid stroma and occasional hypercellular areas. These tumors can, especially on biopsy material, be difficult to distinguish from low-grade fibromyxoid sarcoma or low-grade myxofibrosarcoma. GNAS mutations are frequently involved in IM, in contrast to these other malignant tumors. Read More

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http://dx.doi.org/10.1186/s13000-019-0787-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368757PMC
February 2019
1 Read

Reprogramming Captures the Genetic and Tumorigenic Properties of Neurofibromatosis Type 1 Plexiform Neurofibromas.

Stem Cell Reports 2019 Feb 31;12(2):411-426. Epub 2019 Jan 31.

Hereditary Cancer Group, Germans Trias i Pujol Research Institute (IGTP)-PMPPC-CIBERONC, Can Ruti Campus, Badalona, Barcelona 08916, Spain. Electronic address:

Neurofibromatosis type 1 (NF1) is a tumor predisposition genetic disease caused by mutations in the NF1 tumor suppressor gene. Plexiform neurofibromas (PNFs) are benign Schwann cell (SC) tumors of the peripheral nerve sheath that develop through NF1 inactivation and can progress toward a malignant soft tissue sarcoma. There is a lack of non-perishable model systems to investigate PNF development. Read More

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http://dx.doi.org/10.1016/j.stemcr.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373434PMC
February 2019
3 Reads

Nerve Tumors: What the MSK Radiologist Should Know.

Semin Musculoskelet Radiol 2019 Feb 30;23(1):76-84. Epub 2019 Jan 30.

Department of Health Sciences (DISSAL), University of Genoa, Genova, Italy.

Nerve tumors are rare and heterogeneous soft tissue tumors arising from a peripheral nerve or showing nerve sheath differentiation. In a radiologic setting it is necessary to recognize soft tissue lesions that are of neural origin, their association with a peripheral nerve, and whether they are a true tumor or a so-called pseudotumor such as a neuroma, fibrolipoma, or peripheral nerve sheath ganglion. Ultrasound (US) and magnetic resonance imaging are the best modalities to characterize these lesions. Read More

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http://dx.doi.org/10.1055/s-0038-1676290DOI Listing
February 2019
14 Reads

An Unusual Variant of a Common Palatal Salivary Gland Tumor: Case Report of a Pleomorphic Adenoma with Significant Lipomatous Metaplasia.

Case Rep Dent 2018 25;2018:2052347. Epub 2018 Dec 25.

New York University College of Dentistry, 345 E 24th St, Room 837, NY, New York 10010, USA.

Introduction: Salivary gland tumors are relatively common in the junction of the hard and soft palate area of the oral cavity. Pleomorphic adenoma is considered the most common benign salivary gland tumor in this location. Some of the rarer subtypes of this tumor may have a misleading clinical presentation. Read More

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http://dx.doi.org/10.1155/2018/2052347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323424PMC
December 2018
4 Reads

Coexistence of giant cell tumor of tendon sheath and enchondroma in the middle phalanx of the little finger mimicking a malignant tumor: A case report.

Oncol Lett 2019 Feb 28;17(2):1969-1973. Epub 2018 Nov 28.

Department of Orthopedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima 734-8551, Japan.

Giant cell tumor of the tendon sheath is a type of slow-growing benign soft tissue tumor that typically arises from the synovium of the tendon sheath. Enchondroma is a benign bone tumor comprising of mature hyaline cartilage that centrally develops within the tubular bone. While giant cell tumor of the tendon sheath or enchondroma are common benign soft tissue and bone tumors, respectively the simultaneous occurrence of these tumors in the same region of the hand is exceedingly rare, and it can mimic a malignant tumor, thereby making the diagnosis more challenging. Read More

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http://dx.doi.org/10.3892/ol.2018.9775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341555PMC
February 2019

Diagnostic performance of diffusion-weighted (DWI) and dynamic contrast-enhanced (DCE) MRI for the differentiation of benign from malignant soft-tissue tumors.

J Magn Reson Imaging 2019 Jan 20. Epub 2019 Jan 20.

Department of Radiology, Inje University Haeundae Paik Hospital, Busan, Korea.

Background: A wide range of specificity values for the differentiation of benign and malignant soft-tissue tumors show the limitations of conventional MRI features. The data obtained by quantitative analysis of diffusion-weighted image (DWI) and dynamic contrast-enhanced (DCE) MRIs would provide more objective results, especially in terms of cellularity and perfusion.

Purpose: To evaluate the diagnostic efficacies of DWI and DCE MRI for the differentiation of malignant and benign soft-tissue tumors. Read More

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http://doi.wiley.com/10.1002/jmri.26607
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http://dx.doi.org/10.1002/jmri.26607DOI Listing
January 2019
10 Reads

Primary Osteosarcoma of the Breast: Pathophysiology and Imaging Review.

Curr Probl Diagn Radiol 2019 Jan 3. Epub 2019 Jan 3.

Department of Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Extraskeletal osteosarcoma are rare malignant mesenchymal neoplasms of soft tissues representing around 1% of all soft tissue. The exact mechanism of tumorigenesis of primary breast osteosarcoma is still unclear. However, most of the cases develop without a recognized etiologic factor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03630188183021
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http://dx.doi.org/10.1067/j.cpradiol.2019.01.001DOI Listing
January 2019
11 Reads

Rare metastatic patterns after malignant transformation of serous borderline tumor of the ovary.

J Surg Oncol 2019 May 15;119(6):814-816. Epub 2019 Jan 15.

Division of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.

Serous borderline tumors are rare, benign ovarian neoplasms that may recur and undergo malignant transformation to low-grade serous carcinomas (LGSCs). In this report, a 50-year-old female with a remote history of a serous borderline ovarian tumor experienced a recurrence of LGSC, presenting as a large solitary subcutaneous mass anterior to the sternum after a 33-year disease-free interval. The described case highlights the unpredictable nature of this disease and the importance of implementing lifelong surveillance strategies. Read More

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http://dx.doi.org/10.1002/jso.25380DOI Listing
May 2019
3 Reads

Radiotherapy for parapharyngeal space tumors.

Am J Otolaryngol 2019 Mar - Apr;40(2):289-291. Epub 2018 Dec 21.

Coordinator of the International Head and Neck Scientific Group, Padua, Italy.

A wide variety of tumors, both benign and malignant, occur in the parapharyngeal space. Depending on histology and extent, treatment may include surgery and/or radiotherapy (RT). Herein we discuss the role of RT in the management of some of the more commonly encountered neoplasms, including salivary gland tumors, paragangliomas, schwannomas, and soft-tissue sarcomas. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.12.010DOI Listing
December 2018
2 Reads

Limited biopsies of soft tissue tumors: the contemporary role of immunohistochemistry and molecular diagnostics.

Authors:
Jason L Hornick

Mod Pathol 2019 Jan 2. Epub 2019 Jan 2.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Diagnosing soft tissue tumors is challenging, even on ample incisional biopsies or resection specimens. There are more than 100 distinct types of soft tissue neoplasms, including more than 80 benign and intermediate mesenchymal tumors and around 40 soft tissue sarcomas. Accurate diagnosis relies first upon recognition of characteristic histologic and cytologic features, including architecture, stromal characteristics, vascular patterns, and dominant cytology; these features may not be represented or apparent in limited core needle biopsy or fine needle aspiration specimens. Read More

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http://dx.doi.org/10.1038/s41379-018-0139-yDOI Listing
January 2019

Clinical characteristics and treatment outcomes in six cases of malignant tenosynovial giant cell tumor: initial experience of molecularly targeted therapy.

BMC Cancer 2018 Dec 29;18(1):1296. Epub 2018 Dec 29.

Ludwig Center at Dana-Farber/Harvard and Center for Sarcoma and Bone Oncology, Department of Medical Oncology, Harvard Medical School, Boston, MA, USA.

Background: Although tenosynovial giant cell tumor (TGCT) is classified as a benign tumor, it may undergo malignant transformation and metastasize in extremely rare occasions. High aberrant expression of CSF1 has been implicated in the development of TGCT and recent studies have shown promising activity of several CSF1R inhibitors against benign diffuse-type TGCT; however, little is known about their effects in malignant TGCT.

Case Presentation: Information from six consenting patients (3 men, 3 women) with malignant TGCT presenting to Dana-Farber Cancer Institute for initial or subsequent consultation was collected. Read More

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http://dx.doi.org/10.1186/s12885-018-5188-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311045PMC
December 2018

[Umbilical fibrous hamartoma of infancy: A case report].

Rev Chil Pediatr 2018 Oct;89(5):655-659

Servicio de Anatomía Patológica, Clínica Santa María, Santiago, Chile.

Introduction: Fibrous hamartoma of infancy (FHI) is a benign, soft tissue tumor that usually oc curs in children and has a characteristic histological morphology.

Objective: To describe a case of congenital FHI with atypical histological and clinical characteristics.

Clinical Case: Full-term male newborn, with no perinatal morbid history was referred to dermatology due to a congenital erythe matous plaque in the umbilical region. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000803DOI Listing
October 2018
15 Reads

Radiological Diagnosis of Soft Tissue Tumors in Adults: MRI Imaging of Selected Entities Delineating Benign and Malignant Tumors.

Rofo 2019 Apr 18;191(4):323-332. Epub 2018 Dec 18.

Department of Diagnostic and Interventional Radiology, University-Hospital of Ulm, Germany.

Objective:  MRI is the most important and sensitive imaging modality in the differentiation of unclear soft tissue tumors. A systematic approach helps to narrow down the large number of possible differential diagnoses.

Method:  Our review systematically compares MRI characteristics of the major soft-tissue masses and aims to gain access to these often difficult tumor entities. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0715-2205
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http://dx.doi.org/10.1055/a-0715-2205DOI Listing
April 2019
18 Reads

Alveolar soft-part sarcoma: can MRI help discriminating from other soft-tissue tumors? A study of the French sarcoma group.

Eur Radiol 2018 Dec 17. Epub 2018 Dec 17.

Department of Radiology, Institut Bergonié, Regional Comprehensive Cancer Center, 229 cours de l'Argonne, F-33076, Bordeaux, France.

Objectives: To investigate the imaging features of alveolar soft-part sarcomas (ASPS) on pre-treatment MRI in order to identify relevant criteria to distinguish ASPS from other soft-tissue tumors.

Methods: A series of 25 patients (mean age, 18.5 years old) with histologically proven ASPS from five French comprehensive cancer centers was compared to a control cohort of 292 patients with various histologically proven benign and malignant soft-tissue tumors representative of the 10-year long activity of one center. Read More

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http://link.springer.com/10.1007/s00330-018-5903-3
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http://dx.doi.org/10.1007/s00330-018-5903-3DOI Listing
December 2018
7 Reads

[Analysis of imaging features and treatment strategies of unilateral maxillary sinus and nasal diseases].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1767-1773

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, 100073, China.

To analyze the imaging features of unilateral maxillary sinus nasal lesions and the selection of treatment strategies based on imaging findings for these lesions. The CT and enhanced MRI data of 64 cases of unilateral maxillary sinus and nasal lesions were selected. The imaging findings and surgery approach were observed and recorded. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.23.001DOI Listing
December 2018
1 Read

Diffusion-weighted imaging and diffusion tensor imaging as adjuncts to conventional MRI for the diagnosis and management of peripheral nerve sheath tumors: current perspectives and future directions.

Eur Radiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiology, UT Southwestern Medical Center, Dallas, TX, 75022, USA.

Peripheral nerve sheath tumors (PNSTs) account for ~ 5% of soft tissue neoplasms and are responsible for a wide spectrum of morbidities ranging from localized neuropathy to fulminant metastatic spread and death. MR imaging represents the gold standard for identification of these neoplasms, however, current anatomic MR imaging markers do not reliably detect or differentiate benign and malignant lesions, and therefore, biopsy or excision is required for definitive diagnosis. Diffusion-weighted MR imaging (DWI) serves as a useful tool in the evaluation and management of PNSTs by providing functional information regarding the degree of diffusion, while diffusion tensor imaging (DTI) aids in determining the directional information of predominant diffusion and has been shown to be particularly useful for pre-operative planning of these tumors by delineating healthy and pathologic fascicles. Read More

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http://dx.doi.org/10.1007/s00330-018-5838-8DOI Listing
December 2018
1 Read

Histological Subtypes and Clinical Behavior Evaluation of Salivary Gland Tumors.

Acta Med Port 2018 Nov 30;31(11):641-647. Epub 2018 Nov 30.

Department of Pathology. Centro Hospitalar São João. Porto. Unit of Pathology and Oncology. Department of Pathology. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.

Introduction: Salivary gland tumors include a wide spectrum of histological subtypes and clinical behavior, which we aim to evaluate.

Material And Methods: We performed a retrospective study of all salivary gland tumors diagnosed and treated at the Centro Hospitalar São João, Porto, between 2005 and 2015. Histological re- evaluation was performed in all cases and patient files were reviewed and both clinical and follow-up data were collected. Read More

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http://dx.doi.org/10.20344/amp.9023DOI Listing
November 2018
24 Reads

The Performance of Radiographic Criteria for Bone Malignancy When Applied to Computed Tomography and Magnetic Resonance Imaging.

J Med Imaging Radiat Sci 2018 Mar 26;49(1):84-89. Epub 2017 Nov 26.

Division of Pediatric Oncology, Department of Pediatrics, Kocaeli University School of Medicine, Kocaeli, Turkey.

Background: The conventional radiologic features that differentiate benign from malignant bone lesions were originally described using radiography (x-ray [XR]). When evaluating sectional imaging studies such as magnetic resonance imaging (MRI) and computed tomography (CT), one may apply these principles to identify malignant bone lesions. The aim of this study was to evaluate the performances of these radiographic features for detecting malignity when applied to CT and MRI. Read More

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http://dx.doi.org/10.1016/j.jmir.2017.10.003DOI Listing
March 2018
2 Reads

Solitary fibrous tumor of the stomach with high-grade sarcomatous dedifferentiation.

J Surg Case Rep 2018 Nov 19;2018(11):rjy307. Epub 2018 Nov 19.

Department of Surgery, Creighton University Medical Center, Omaha, NE, USA.

Solitary fibrous tumors (SFT) are uncommon fibroblastic mesenchymal neoplasms that display a wide range of histologic behaviors. These tumors, which are estimated to account for 2% of all soft tissue neoplasms, typically follow a benign clinical course. However, it is estimated that 10-30% of SFTs are malignant and demonstrate aggressive behavior with local recurrence and metastasis up to several years after surgical resection. Read More

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https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjy30
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http://dx.doi.org/10.1093/jscr/rjy307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240737PMC
November 2018
13 Reads

Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.

Head Neck Pathol 2018 Nov 22. Epub 2018 Nov 22.

Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.

Head and neck pathology present a unique set of challenges including the morphological diversity of the neoplasms and presentation of metastases of unknown primary origin. The detection of human papillomavirus and Epstein-Barr virus associated with squamous cell carcinoma and newer entities like HPV-related carcinoma with adenoid cystic like features have critical prognostic and management implications. In salivary gland neoplasms, differential diagnoses can be broad and include non-neoplastic conditions as well as benign and malignant neoplasms. Read More

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http://dx.doi.org/10.1007/s12105-018-0988-1DOI Listing
November 2018
19 Reads

Diagnostic Imaging and Management of Common Intra-articular and Peri-articular Soft Tissue Tumors and Tumorlike Conditions of the Knee.

J Knee Surg 2019 Apr 16;32(4):322-330. Epub 2018 Nov 16.

Department of Orthopedic Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina.

Intra-articular (IA) and peri-articular (PA) tumors of the knee are frequently encountered by orthopaedic surgeons. Nonetheless, due to the possibility of great morbidity and potential mortality, it is important to recognize and differentiate between benign and malignant lesions in a timely manner. Therefore, the purpose of this article is to provide a concise, practical, and updated review of commonly encountered IA and PA tumors including intratendinous gout, synovial chondromatosis, schwannoma, pigmented villonodular synovitis, and synovial sarcoma, and a detailed description of differentiating features to include various imaging modalities. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1675609
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http://dx.doi.org/10.1055/s-0038-1675609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445722PMC
April 2019
15 Reads

Mesenchymal Neoplasms of the Genitourinary System: A Selected Review with Recent Advances in Clinical, Diagnostic, and Molecular Findings.

Surg Pathol Clin 2018 Dec;11(4):837-876

Departments of Pathology and Urology, VCU School of Medicine, 1200 East Marshall Street, PO Box 980662, Richmond, VA 23298, USA. Electronic address:

Mesenchymal neoplasms of the genitourinary (GU) tract often pose considerable diagnostic challenges due to their wide morphologic spectrum, relative rarity, and unexpected incidence at GU sites. Soft tissue tumors arise throughout the GU tract, whether from adventitia surrounding or connective tissues within the kidneys, urinary bladder, and male and female genital organs. This selected article focuses on a subset of these lesions, ranging from benign to malignant and encompassing a range of patterns of mesenchymal differentiation, where recent scholarship has lent greater insight into their clinical, molecular, or diagnostic features. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18759181183004
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http://dx.doi.org/10.1016/j.path.2018.07.008DOI Listing
December 2018
12 Reads

Concurrent Congenital Fibrolipomatous Hamartoma and Congenital Nevus of Infancy: A Syndromic or Chance Association.

J Indian Assoc Pediatr Surg 2018 Oct-Dec;23(4):219-221

Department of Pediatric Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Congenital nevi and fibrolipomatous hamartoma are benign tumors of childhood, the latter being very uncommon. Fibrous hamartoma of infancy typically occurs in <2 years of life. The concurrence of these two lesions is extremely rare. Read More

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http://dx.doi.org/10.4103/jiaps.JIAPS_163_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182949PMC
November 2018
4 Reads

Approaches for Excision of Intramasseteric Nodules.

J Craniofac Surg 2019 Jan;30(1):e92-e94

Department of Plastic and Reconstructive Surgery, National Defense Medical College, Saitama, Japan.

Developmental lesions, including benign or malignant tumors, rarely arise in the masseteric region. This retrospective study was performed to evaluate the adequacy of different surgical approaches in a series of patients with lesions in the masseteric region. The surgical methods, postoperative complications, pathological diagnosis, and aesthetic outcome were compared in 4 patients who underwent excision of intramasseteric mass lesions. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005001DOI Listing
January 2019
14 Reads

Clinicopathologic features of anaplastic myxopapillary ependymomas.

Brain Pathol 2019 01;29(1):75-84

Department of Pathology, University of California, San Francisco, CA.

Myxopapillary ependymomas (MPE) are considered benign (World Health Organization (WHO) grade I) neoplasms with favorable prognosis. However, malignant behavior occurs in a small subset. To our knowledge, only five anaplastic MPEs have been reported without consensus on diagnostic criteria. Read More

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http://doi.wiley.com/10.1111/bpa.12673
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http://dx.doi.org/10.1111/bpa.12673DOI Listing
January 2019
18 Reads
3.840 Impact Factor

Length Scale Matters: Real-Time Elastography versus Nanomechanical Profiling by Atomic Force Microscopy for the Diagnosis of Breast Lesions.

Biomed Res Int 2018 16;2018:3840597. Epub 2018 Oct 16.

Gynecology and Gynecologic Oncology, Claraspital, 4016 Basel, Switzerland.

Real-time elastography (RTE) is a noninvasive imaging modality where tumor-associated changes in tissue architecture are recognized as increased stiffness of the lesion compared to surrounding normal tissue. In contrast to this macroscopic appraisal, quantifying stiffness properties at the subcellular level by atomic force microscopy (AFM) reveals aggressive cancer cells to be soft. We compared RTE and AFM profiling of the same breast lesion to explore the diagnostic potential of tissue elasticity at different length scales. Read More

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http://dx.doi.org/10.1155/2018/3840597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206582PMC
February 2019
3 Reads

Rare granular cell tumor affecting a 13-year-old boy.

Indian J Dent Res 2018 Sep-Oct;29(5):687-689

Consultant, Department of Oral and Maxillofacial Surgery, Balaji Dental and Craniofacial Hospital, Chennai, Tamil Nadu, India.

Granular cell tumor (GCT) is a rare soft-tissue neoplasm, first described in 1926. GCT often manifests as a single, painless nodule that shows a slow enlargement in the cutaneous, subcutaneous, or submucosal tissues. It is commonly reported in adults in the third to sixth decade of life. Read More

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http://www.ijdr.in/text.asp?2018/29/5/687/244947
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http://dx.doi.org/10.4103/ijdr.IJDR_651_18DOI Listing
March 2019
15 Reads

Comparison of breast cancer detection and depiction between planar and rotating synthetic mammography generated from breast tomosynthesis.

Eur J Radiol 2018 Nov 19;108:78-83. Epub 2018 Sep 19.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

Purpose: To compare breast cancer detection and depiction between planar synthetic mammography (SM) and rotating synthetic mammography (RM) generated from digital breast tomosynthesis (DBT).

Materials And Methods: In a fully-crossed multi-reader multi-case (MRMC) study, three radiologists retrospectively reviewed 190 cases (27 malignant, 31 benign, 132 normal), once with SM alone and once with RM alone, the DBT stack of slices was not reviewed. Lesions were scored using BI-RADS® and level of suspiciousness (1-10). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183032
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http://dx.doi.org/10.1016/j.ejrad.2018.09.022DOI Listing
November 2018
16 Reads

Loss of TRIM29 Alters Keratin Distribution to Promote Cell Invasion in Squamous Cell Carcinoma.

Cancer Res 2018 Dec 2;78(24):6795-6806. Epub 2018 Nov 2.

Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.

: TRIM29 (tripartite motif-containing protein 29) is a TRIM family protein that has been implicated in breast, colorectal, and pancreatic cancers. However, its role in stratified squamous epithelial cells and tumors has not been elucidated. Here, we investigate the expression of TRIM29 in cutaneous head and neck squamous cell carcinomas (SCC) and its functions in the tumorigenesis of such cancers. Read More

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-1495DOI Listing
December 2018
46 Reads

Pediatric Anastomosing Hemangioma: Case Report and Review of Renal Vascular Tumors in Children.

Pediatr Dev Pathol 2018 Oct 28:1093526618809230. Epub 2018 Oct 28.

5 Department of Pathology and Laboratory Medicine, National Kidney and Transplant Institute, Philippines.

The case involves a 10-year-old child who underwent a left radical nephrectomy for what was believed to be a Wilms' tumor. Histopath examination indicated a benign vascular lesion, subsequently determined to be an anastomosing hemangioma of the kidney. A comparison with the previously cited pediatric patients with renal vascular tumors is provided, and the inconsistent diagnostic terminologies for these conditions are highlighted. Read More

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http://dx.doi.org/10.1177/1093526618809230DOI Listing
October 2018
16 Reads

Mandibular Reconstruction with Free Vascularized Fibular Graft.

Bull Tokyo Dent Coll 2018 Nov 18;59(4):299-311. Epub 2018 Oct 18.

Department of Oral and Maxillofacial Surgery, Tokyo Dental College.

An iliac block graft is the most commonly used biomaterial for reconstruction following resection of the mandible. Its use has some disadvantages, however, including limitations on the amount of bone that may be harvested, and the subsequent increase in burden on the iliac bone. Therefore, recently, free vascularized fibular grafts have been used as an alternative in some cases. Read More

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https://www.jstage.jst.go.jp/article/tdcpublication/advpub/0
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http://dx.doi.org/10.2209/tdcpublication.2017-0025DOI Listing
November 2018
12 Reads

Bone and Soft Tissue Tumors About the Foot and Ankle.

Radiol Clin North Am 2018 Nov 17;56(6):917-934. Epub 2018 Sep 17.

Department of Diagnostic Radiology, The University of Texas, MD Anderson Cancer Center, 1400 Pressler Street, Unit 1475, Houston, TX 77030, USA. Electronic address:

The foot and ankle delicately balance the need for support of the weight of the human body, with the need for flexibility. Palpable masses about the foot and ankle, therefore, are most commonly related to trauma or mechanical instability. Non-neoplastic causes, such as ganglion cysts and callus, therefore, predominate. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00338389183007
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http://dx.doi.org/10.1016/j.rcl.2018.06.010DOI Listing
November 2018
17 Reads

Common Tumors and Tumor-like Lesions of the Shoulder.

J Am Acad Orthop Surg 2019 Apr;27(7):236-245

From the Department of Orthopaedics (Dr. Lee and Dr. Hills) and the Department of Radiology (Dr. Jordanov), Vanderbilt University Medical Center, Nashville, TN, and the OrthoSports Associates (Dr. Jaffe), Birmingham, AL.

Shoulder lesions range from tumor-like lesions such as simple bone cysts to aggressive high-grade sarcomas. The clinical presentation is often nonspecific with shoulder pain as the primary complaint, which may lead to a delayed or missed diagnosis. Delayed diagnosis or a poorly planned biopsy of a malignant shoulder lesion can have a detrimental effect on the patient's prognosis and treatment options. Read More

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http://Insights.ovid.com/crossref?an=00124635-900000000-9952
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http://dx.doi.org/10.5435/JAAOS-D-17-00449DOI Listing
April 2019
4 Reads