351 results match your criteria Benign Vulvar Lesions


Clitoral leiomyoma in a premenopausal woman: a case report.

BMC Womens Health 2020 May 1;20(1):89. Epub 2020 May 1.

Department of Obstetrics and Gynaecology, Geneva University Hospitals, 30 Bld de la Cluse, 1211, Geneva, Switzerland.

Background: Extrauterine leiomyomata is an uncommon lesion that can lead to several problems of differential diagnosis, especially when localized in the external genitalia. There are few reports in the English literature and a novel association with Alport's syndrome has been investigated since the 1980s.

Case Presentation: Here, we describe the case of a premenopausal woman who presented with an indolent swelling of the right interlabial fossa that resulted in a Bartholin cyst. Read More

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http://dx.doi.org/10.1186/s12905-020-00959-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195734PMC

Robotic resection of a large ovarian leiomyoma.

Minerva Chir 2020 Apr;75(2):121-124

Division of General, Minimally Invasive and Robotic Surgery, University of Illinois at Chicago, Chicago, IL, USA.

Uterine leiomyomata are the most frequent leiomyomata. However, this benign tumor can also arise in unusual locations (e.g. Read More

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http://dx.doi.org/10.23736/S0026-4733.20.08253-XDOI Listing

Protease inhibitor effects on prevalence of bacterial vaginosis and human papillomavirus-related lesions.

J Obstet Gynaecol Res 2020 Mar 17. Epub 2020 Mar 17.

Department of Gynaecology, Rio de Janeiro State University, Rio de Janeiro, Brazil.

Aim: Antiretrovirals of the protease inhibitor (PI) class tend to achieve low concentrations in biological fluids. This study aimed to analyze possible changes in the vaginal microbiome and frequency of cervical human papillomavirus (HPV)-DNA and HPV-related lesions associated with the use of PI in antiretroviral therapy (ART).

Methods: Eighty-eight women with human immunodeficiency virus infection were divided in two groups: ART with PI and without PI. Read More

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http://dx.doi.org/10.1111/jog.14245DOI Listing

Concordance rate of vulvoscopic findings in detecting early vulvar neoplasia.

Gynecol Oncol 2020 May 24;157(2):463-468. Epub 2020 Feb 24.

Department of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CCC ER-EMN), Universitätsstrasse 21-23, 91054 Erlangen, Germany.

Purpose: Colposcopy-guided punch biopsy is a cornerstone method for diagnosing vulvar diseases. The aim of this study was to evaluate the concordance rate of clinical findings in vulvar diseases during examinations, in comparison with colposcopy-directed punch biopsy. We also developed a new classification to simplify the categorization of vulvoscopic findings. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.02.026DOI Listing

Granular cell tumor a study of 42 cases and systemic review of the literature.

Pathol Res Pract 2020 Apr 12;216(4):152865. Epub 2020 Feb 12.

Department of Pathology, North Hospital, University Hospital of St-Etienne, France.

Background: Granular cell tumor (GCT) remains a diagnostic clinicopathologic problem because the exact frequency of its detailed morphological and clinical characteristics is unknown as most observations are collected from small series or isolated cases. Herein, our aim is to highlight the frequency of all clinicopathological characteristics of this rare tumor based in our series and the available medical (PubMed) literature.

Material And Methods: 42 cases were evaluated for: tissue layers involved by the tumor (in skin and mucosae), growth pattern, nuclear pleomorphism, mitotic index, necrosis, spindling, calcification, hyalinization, and pustule-ovoid bodies of Milian, as well as perineural and vascular invasion, and the presence of adjacent epithelium changes, and lymphocytes and eosinophils infiltration. Read More

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http://dx.doi.org/10.1016/j.prp.2020.152865DOI Listing

The usefulness of high-frequency ultrasonography in the evaluation of vulvar dermatoses in postmenopausal women - a preliminary report.

J Ultrason 2019 Dec 31;19(79):282-286. Epub 2019 Dec 31.

Clinical Unit of Obstetrics, Women's Disease and Gynecological Oncology, United District Hospital, Collegium Medicum University of Nicolaus Copernicus in Toruń, Torun, Poland.

Introduction: The vulva is an external female genital organ with complex anatomy and histology. In postmenopausal women, this region is at particular risk of different types of conditions known as dermatoses.

Materials And Methods: We assessed benign vulvar skin lesions using high-frequency 48 MHz ultrasound transducer (DermaView) prior to biopsy or excision. Read More

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http://dx.doi.org/10.15557/JoU.2019.0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988568PMC
December 2019

Human papillomavirus genotype distribution in genital warts among women in Harare-Zimbabwe.

J Obstet Gynaecol 2019 Dec 2:1-7. Epub 2019 Dec 2.

Department of Obstetrics and Gynaecology, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.

This study aimed to determine the prevalence of HPV genotypes in genital warts among women in Harare, Zimbabwe. Women aged 18-45 years attending gynaecology and genitourinary clinics with a clinical diagnosis of genital-warts were recruited. HPV-DNA was extracted from tissue biopsies. Read More

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http://dx.doi.org/10.1080/01443615.2019.1673710DOI Listing
December 2019

Cryotherapy of Genital Warts.

Authors:
Mahira Jahic

Mater Sociomed 2019 Sep;31(3):212-214

Gynecology centre ,,Dr Mahira Jahić" Tuzla, Bosnia and Herzegovina.

Introduction: Genital warts are a frequent form of sexually transmitted disease. Cryotherapy represents the first line of therapy. Healing occurs in 94%, and recurrence in 10% . Read More

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http://dx.doi.org/10.5455/msm.2019.31.212-214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853748PMC
September 2019

Post Treatment Application of Jaungo after a Combined Therapy of Carbon Dioxide Laser and Trichloroacetic Acid in a Case of Vulvar Syringoma.

J Pharmacopuncture 2019 Sep 30;22(3):200-203. Epub 2019 Sep 30.

Division of Pharmacology, College of Korean Medicine, Semyung University, Jecheon, South Korea.

Syringoma is a benign eccrine sweat gland tumor that predominantly appears in females during puberty with multiple smooth papules measuring 1-2 mm in diameter. Common locations are on lower eyelids and cheeks. Vulvar syringoma is quite a rare, occurring condition with only a few cases reported. Read More

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http://dx.doi.org/10.3831/KPI.2019.22.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820478PMC
September 2019
1 Read

HPV infection in urology practice.

Int Urol Nephrol 2020 Jan 3;52(1):1-8. Epub 2019 Oct 3.

Department of Urology, Gozde Academy Hospital, Malatya, Turkey.

Human papillomavirus (HPV) is the most common pathogen of sexually transmitted disease worldwide. While HPV is responsible for low-grade benign lesions in the anogenital area such as condyloma acuminatum, it is also strongly associated with cervical, anal, vulvar/vaginal, and penile carcinomas. In addition to being an oncogenic virus, HPV causes a substantial socioeconomic burden due to the recurrence of benign lesions, the lack of a definitive treatment option that provides a complete cure, and the high cost of treatment. Read More

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http://link.springer.com/10.1007/s11255-019-02302-2
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http://dx.doi.org/10.1007/s11255-019-02302-2DOI Listing
January 2020
8 Reads

Tumors of the reproductive tract of sheep and goats: A review of the current literature and a report of vaginal fibroma in an Awassi ewe.

Vet World 2019 Jun 11;12(6):778-782. Epub 2019 Jun 11.

Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Aims: This study aimed to provide a summary of all online available literature of published clinical and histopathological data regarding tumors affecting the reproductive tract of female sheep and goats. In addition, a detailed description of the clinical history, clinical findings, and gross and histopathological findings of one case of vaginal fibroma in an adult Awassi sheep is provided for the first time.

Materials And Methods: Internet search engines such as PubMed, ResearchGate, Scopus, ScienceDirect, and Google Scholar were used to collect all published articles in refereed journals from 2000 to 2018 regarding tumors and tumor-like lesions involving the reproductive tract of ewes and does. Read More

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http://dx.doi.org/10.14202/vetworld.2019.778-782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661476PMC
June 2019
6 Reads

No. 385-Indications for Pelvic Examination.

J Obstet Gynaecol Can 2019 Aug;41(8):1221-1234

Winnipeg, MB (GOC).

Objective: The primary objective of this document is to clarify the indications for pelvic examination.

Intended Users: Physicians, including gynaecologists, obstetricians, family physicians, and emergency physicians; nurses, including registered nurses and nurse practitioners; midwives, including midwives in clinical practice and midwifery trainees; medical trainees, including medical students, residents, and fellows; and all other health care providers who care for women.

Target Population: This publication provides evidence and expert-based recommendations for pelvic examination in adult women (18 years and older) both with and without gynaecologic symptoms. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.12.007DOI Listing
August 2019
7 Reads

Primary Benign Phyllodes Tumor of The Vulva: Case Report and Review of Literature.

Eur J Breast Health 2019 Jul 1;15(3):196-199. Epub 2019 Jul 1.

Department of Gynecology and Obstetrics, Ahi Evran University Training and Research Hospital, Kırşehir, Turkey.

Phyllodes tumor (PT) of the vulva is very rarely seen and has been reported in only 17 cases in English literature. It is still uncertain that proliferative mammary gland lesions including PT in the anogenital region originate from ectopic breast tissue or from local adnexal structures. We report a case of primary benign PT of the vulva in a 41-year-old female patient. Read More

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http://dx.doi.org/10.5152/ejbh.2019.4391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619780PMC
July 2019
3 Reads

Angiofibroma of the Vagina Presenting with Abnormal Vaginal Bleeding: A Case Report from Ethiopia and Review of the Literature.

Case Rep Obstet Gynecol 2019 2;2019:1486387. Epub 2019 Jun 2.

Department of Obstetrics and Gynecology, Jimma University, Ethiopia.

Background: Angiofibroma is an uncommon type of vascular benign tumor that is made up of blood vessels and fibrous (connective) tissue. First described in 1997, it usually occurs in middle aged females and is clinically often thought to represent a cyst. Unlike most of the other site specific vulvovaginal mesenchymal lesions, cellular angiofibroma has a marked predilection for the vulva with only occasional examples reported in the vagina. Read More

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http://dx.doi.org/10.1155/2019/1486387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582828PMC
June 2019
2 Reads

Several genotypes, one phenotype: PIK3CA/AKT1 mutation-negative hidradenoma papilliferum show genetic lesions in other components of the signalling network.

Pathology 2019 Jun 19;51(4):362-368. Epub 2019 Apr 19.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

About 60-70% of hidradenoma papilliferum (HP), a benign tumour of the anogenital region, were recently described to harbour mutations in major driver genes of the PI3K/AKT/MAPK-signalling pathways. However, the underlying genetic defects of the non-mutant cases are still unknown. Using a 409 gene panel, we employed targeted next generation sequencing to investigate the mutational landscape in a cohort of seven PI3K/AKT-negative cases and five cases with known hotspot mutations in either PIK3CA or AKT1. Read More

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http://dx.doi.org/10.1016/j.pathol.2019.01.010DOI Listing
June 2019
9 Reads

A pregnant woman with condyloma acuminatum on the vaginal orifice, areola, groin, and umbilicus.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):310-312

Infectious Disease Center, Peking University Ditan Teaching Hospital; Department of Dermatology and Venereology, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China.

Condyloma acuminatum (CA) is a benign tumor primarily caused by infection with human papillomavirus (HPV) type-6 or type-11, lesions of which are most frequently found on the genital, perianal squamous mucosa, and skin. CA outside the anogenital region is not common. Here, we report a case showing simultaneous presence of CA on the vaginal orifice, areola, groin, and umbilicus in a 32-year-old pregnant woman. Read More

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http://www.ijpmonline.org/text.asp?2019/62/2/310/255829
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http://dx.doi.org/10.4103/IJPM.IJPM_518_18DOI Listing
August 2019
34 Reads

Giant Fibroepithelial Polyp of Vulva: A Case Report and Review of Literature.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):127-130

Department of Gynecology and Obstetrics, Clinical Hospital, Tetovo, Republic of Macedonia.

Fibroepithelial stromal polyps of vulva are the type of mesenchymal lesion that typically occurs in women of reproductive period. They are common, usually small and hystologically benign. Larger lesions are rare and likely arise from proliferation of mesenchymal cells within the hormonally sensitive subepithelial stromal layer of the lower genital tract. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0051DOI Listing
December 2018
17 Reads

Primary lymphangioma circumscriptum of the vulva presenting as warty plaques.

Australas J Dermatol 2019 Nov 27;60(4):305-307. Epub 2019 Feb 27.

Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Lymphangioma circumscriptum is a benign hamartomatous malformation involving the lymphatic system of skin and subcutaneous tissue. It can involve any part of the body with maximum predilection for proximal parts of limbs. Vulvar involvement is quite infrequent. Read More

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http://doi.wiley.com/10.1111/ajd.13014
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http://dx.doi.org/10.1111/ajd.13014DOI Listing
November 2019
32 Reads

Laparoscopic management of a large urethral leiomyoma.

Int Urogynecol J 2019 07 12;30(7):1211-1213. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, University of Brescia, Brescia, Italy.

Introduction And Hypothesis: A 42-year-old female presented with a 12-cm mass bulging the anterior vaginal wall and causing urgency urinary incontinence and bulk symptoms.

Methods: Imaging showed a tumor originating from the dorsal and cranial part of the urethra and developing in the vesicouterine space and vesicovaginal septum, dislocating the bladder ventrally and the uterus cranial-dorsally.

Results: Tranvaginal biopsy showed a benign leiomyoma. Read More

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http://dx.doi.org/10.1007/s00192-019-03889-xDOI Listing
July 2019
12 Reads

Acquired angiokeratomas of the vulva.

Indian J Sex Transm Dis AIDS 2018 Jul-Dec;39(2):136-138

Department of Dermatology, Dr. D. Y. Patil Medical College and Hospital, Pune, Maharashtra, India.

Angiokeratomas are benign cutaneous lesions consisting of numerous ectatic blood vessels present in the superficial dermis and usually involving the scrotum. Although usually asymptomatic, they may be complicated by sporadic or profuse bleeding. We report the development of multiple vulvar angiokeratomas in a 40-year-old female after undergoing a perineoplasty successfully treated with electrocautery. Read More

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http://www.ijstd.org/text.asp?2018/39/2/136/247087
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http://dx.doi.org/10.4103/ijstd.IJSTD_50_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298145PMC
January 2019
10 Reads

Recurrent, nodular lesions over the vulva: A diagnostic challenge.

Indian J Sex Transm Dis AIDS 2018 Jul-Dec;39(2):124-126

Department of Dermatology, Father Muller Medical College, Mangalore, Karnataka, India.

Angiokeratomas are benign tumors characterized by proliferation and dilatation of blood vessels in the upper dermis. They are divided into widespread and localized forms. The localized forms are further classified as angiokeratoma of Fordyce, angiokeratoma circumscriptum neviforme, circumscribed angiokeratoma, and angiokeratoma of Mibelli, of which angiokeratoma of Fordyce is the most common. Read More

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http://dx.doi.org/10.4103/ijstd.IJSTD_101_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298154PMC
January 2019
8 Reads

Distinction of Condylomata Acuminata From Vulvar Vestibular Papules or Pearly Penile Papules Using Ki-67 Immunostaining.

J Cutan Med Surg 2019 May/Jun;23(3):255-257. Epub 2018 Dec 17.

1 Departments of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Background: Ki-67 is an immunohistochemical stain used as a nuclear proliferation marker. It is nonspecific, and is expressed in all active phases of the cell cycle. Vulvar vestibular papules in women and pearly penile papules in men are benign fibrous papules on the genitals, are noninfectious, and do not require treatment. Read More

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http://dx.doi.org/10.1177/1203475418819992DOI Listing
December 2019
34 Reads

Adaptation of Alpha-Papillomavirus over Millennia.

Acta Cytol 2019 13;63(2):97-99. Epub 2018 Dec 13.

Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil,

Papillomaviruses (PVs) are a group of small DNA viruses that, with around 350 million years of evolution, acquired the capacity of infecting a broad range of vertebrates, including humans. To date, more than 300 PV types have been isolated. Viruses that have a long common evolutionary history with their host typically cause unapparent infections. Read More

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https://www.karger.com/Article/FullText/492658
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http://dx.doi.org/10.1159/000492658DOI Listing
May 2019
33 Reads

Multiple Epidermolytic Acanthomas: Rare Vulval Lesions Which May be Mistaken for Viral Warts.

Int J Gynecol Pathol 2020 Jan;39(1):93-96

Departments of Pathology (S.I., A.K., W.G.M.) Dermatology (S.H.), Belfast Health and Social Care Trust Belfast Skin Clinic (P.M.) Centre for Medical Education, Queen's University (J.H.), Belfast Department of Pathology, Southmead Hospital, Bristol (K.M.) Department of Pathology, Antrim Area Hospital, Antrim, UK (J.J.).

Epidermolytic acanthoma is a rare benign lesion that most often presents as a solitary or multiple small papular lesions on the trunk, face, limbs or external male genitalia. Only a small number of cases have been reported occurring on the vulva and clinically and histologically they may mimic and be misdiagnosed as viral warts. We report 2 cases of multiple epidermolytic acanthomas localized to the vulva. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000570DOI Listing
January 2020
55 Reads

A Case Report of Scrotal Rejuvenation: Laser Treatment of Angiokeratomas of the Scrotum.

Authors:
Philip R Cohen

Dermatol Ther (Heidelb) 2019 Mar 26;9(1):185-192. Epub 2018 Nov 26.

San Diego Family Dermatology, National City, CA, USA.

Scrotal rejuvenation encompasses not only the functional quality but also the aesthetic appearance of the scrotum. It includes medical therapy and procedural interventions to improve scrotal conditions that require morphologic restoration and/or aesthetic alteration. Rejuvenation of the scrotum may be appropriate for aging-related and non-aging-related changes concerning the hair (alopecia and hypertrichosis), the morphology (laxity and wrinkles), and/or the vascularity (angiokeratoma) of the scrotum. Read More

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http://link.springer.com/10.1007/s13555-018-0272-z
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http://dx.doi.org/10.1007/s13555-018-0272-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380972PMC
March 2019
20 Reads

Melanocytic lesions - Staying out of trouble.

Authors:
Thomas Brenn

Ann Diagn Pathol 2018 Dec 27;37:91-102. Epub 2018 Sep 27.

Department of Pathology & Laboratory Medicine, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary, AB T2L 2K8, Canada; Department of Medicine, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary, AB T2L 2K8, Canada; The Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary AB T2L 2K8, Canada; Department of Pathology, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, United Kingdom. Electronic address:

The diagnosis of melanocytic tumors is notoriously difficult and represents one of the most challenging areas in surgical pathology associated with significant risk for litigation. One reason is the wide morphologic spectrum of melanocytic tumors and the fact that many histological features are shared by both benign melanocytic nevi and melanoma. Awareness of the many morphologic variations and variants of nevi and melanoma, their clinical setting, immunohistochemical phenotype and genetic profile is necessary for the correct diagnosis. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.010DOI Listing
December 2018
14 Reads

Granular cell tumor: A report of three cases and review of literature.

Cancer Biomark 2018 ;23(2):173-178

Department of Obstetrics and Gynecology, The Hongqi Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157000, Heilongjiang, China.

Objective: In order to improve the understanding of granular cell tumor and avoid missing the best time of treatment, we report three patients with rare granular cell tumors admitted to our hospital in the past 10 years.

Methods: The characteristics, methods of treatment, postoperative pathological results and follow-up results of three cases of granular cell tumor were analyzed; and literatures related to granular cell tumors were reviewed.

Results: All patients underwent surgical treatment, and the excised lesions were sent to the laboratory for testing. Read More

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/CBM-170556DOI Listing
February 2019
14 Reads

Detection of bovine papillomavirus type 2 DNA in calf conjunctival myofibroblastoma.

J Vet Med Sci 2018 Nov 30;80(10):1544-1548. Epub 2018 Aug 30.

Hokkaido Research Station, National Institute of Animal Health, National Agriculture and Research Organization, 4 Hitsujigaoka, Toyohira, Sapporo, Hokkaido 062-0045, Japan.

An 8-month-old male Japanese Black calf was referred for the evaluation of a slow-growing conjunctival mass in the right eye. A superficial keratectomy was performed followed by recurrence on two occasions. No metastases were found in surrounding tissues. Read More

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http://dx.doi.org/10.1292/jvms.18-0341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207528PMC
November 2018
53 Reads

Evaluation of large clinically atypical vulvar pigmentation with RCM: atypical melanosis or early melanoma?

J Eur Acad Dermatol Venereol 2019 Jan 12;33(1):84-92. Epub 2018 Jul 12.

Dermatology Department, Centre Hospitalier de Lyon Sud, Hospices civils de Lyon, Université Claude Bernard Lyon 1, Pierre Bénite, France.

Background: Vulvar melanosis can occasionally be clinically challenging by mimicking an early melanoma.

Objective: To report our experience of initial evaluation and follow-up in this peculiar subset of vulvar melanosis using reflectance confocal microscopy (RCM).

Methods: We retrospectively evaluated 18 consecutive cases referred for atypical vulvar pigmentation or for which melanoma was considered and that underwent both RCM examination and histopathological assessment. Read More

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http://dx.doi.org/10.1111/jdv.15141DOI Listing
January 2019
33 Reads

Large Vaginal Varicosities in the Setting of Pregnancy without Known Hepatic or Vascular Risks: A Case Report and Review of the Literature.

Case Rep Obstet Gynecol 2018 22;2018:2394695. Epub 2018 Jan 22.

School of Medicine, Loma Linda University, Loma Linda, CA, USA.

Pregnancy may cause the onset of vaginal or vulvar varicosities that may be a concern for hemorrhage risk during childbirth. A 38-year-old female G4P1112 at 34 weeks and 1 day was referred to an outpatient OB/Gyn clinic for evaluation of a large vaginal mass. The referring provider had concern for malignancy. Read More

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http://dx.doi.org/10.1155/2018/2394695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827883PMC
January 2018
7 Reads

Ultrasonography of benign vulvar lesions.

Ultrasonography 2018 Oct 13;37(4):355-360. Epub 2018 Feb 13.

Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong.

With the increasing applications of ultrasonography in the field of dermatology, this imaging modality can be extended to identify and characterize common vulvar lesions, with a particular focus on their location, size, vascularity, and content. This pictorial essay provides an introduction to vulvar ultrasonography, including technical considerations, ultrasonographic anatomy, and the ultrasonographic appearances of some vulvar conditions. Read More

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http://dx.doi.org/10.14366/usg.18001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177693PMC
October 2018
13 Reads

Pediatric Granular Cell Tumors of the Vulva: A Report of 4 Cases and a Review of the Literature.

J Pediatr Adolesc Gynecol 2018 Jun 3;31(3):311-314. Epub 2018 Jan 3.

Department of Gynecology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts.

Background: Granular cell tumors (GCTs) are rare soft tissue lesions that can involve the female genital tract, including the vulva. Although malignant tumors are aggressive and uncommon, benign and atypical lesions still have associated risks, including recurrence and multisite development.

Cases: Four cases of pediatric vulvar GCT are presented, including 1 atypical and 3 benign tumors. Read More

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http://dx.doi.org/10.1016/j.jpag.2017.12.010DOI Listing
June 2018
27 Reads

Comparison of F-FDG PET/MRI and MRI alone for whole-body staging and potential impact on therapeutic management of women with suspected recurrent pelvic cancer: a follow-up study.

Eur J Nucl Med Mol Imaging 2018 04 21;45(4):622-629. Epub 2017 Nov 21.

Medical Faculty, Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, D-45147, Essen, Germany.

Purpose: To evaluate the diagnostic performance of F-FDG PET/MRI for whole-body staging and potential changes in therapeutic management of women with suspected recurrent pelvic cancer in comparison with MRI alone.

Methods: Seventy-one consecutive women (54 ± 13 years, range: 25-80 years) with suspected recurrence of cervical (32), ovarian (26), endometrial (7), vulvar (4), and vaginal (2) cancer underwent PET/MRI including a diagnostic contrast-enhanced MRI protocol. PET/MRI and MRI datasets were separately evaluated regarding lesion count, localization, categorization (benign/malignant), and diagnostic confidence (3-point scale; 1-3) by two physicians. Read More

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http://dx.doi.org/10.1007/s00259-017-3881-3DOI Listing
April 2018
41 Reads

Vulvar Nodules: A Rare Presentation of Mastocytosis.

J Pediatr Adolesc Gynecol 2018 Apr 21;31(2):156-157. Epub 2017 Nov 21.

Department of Obstetrics and Gynecology, Division of Pediatric and Adolescent Gynecology, UT Southwestern Medical Center, Children's Health, Dallas, Texas.

Background: Mastocytosis is a rare benign disorder characterized by the finding of mast cells in the skin and other organs, occurring in adult as well as pediatric age groups. The cutaneous form is the most common presentation in childhood and is rarely located on the vulva.

Case: A 9-year-old prepubertal girl presented with bilateral vulvar nodules found incidentally by her pediatrician. Read More

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http://dx.doi.org/10.1016/j.jpag.2017.11.006DOI Listing
April 2018
17 Reads

Nodular Hyperplasia of the Bartholin Gland, A Benign Mimicker of Aggressive Angiomyxoma: A Case Series and Literature Review.

Int J Gynecol Pathol 2018 Nov;37(6):554-558

Department of Pathology and Microbiology (Y.A.T.), University of Nebraska Medical Center, Omaha, Nebraska; Department of Pathology and Laboratory Medicine (Y.A.T., W.D.L., S.E.S.), The Warren Alpert Medical School of Brown University and Women & Infants Hospital, Providence, Rhode Island.

Nodular hyperplasia (NH) of the Bartholin gland is an exceedingly rare benign solid lesion of the female genital tract that can mimic the Bartholin gland cyst clinically. The histologic criteria for NH were established in 1998 by Koenig and Tavassoli. In this case series, we describe 4 cases of NH from Women and Infants Hospital in Rhode Island. Read More

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http://Insights.ovid.com/crossref?an=00004347-900000000-9925
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http://dx.doi.org/10.1097/PGP.0000000000000456DOI Listing
November 2018
27 Reads

Clinician's Update on the Benign, Premalignant, and Malignant Skin Tumours of the Vulva: The Dermatologist's View.

Int Sch Res Notices 2017 25;2017:2414569. Epub 2017 Jul 25.

Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.

Correct and rapid diagnosis of skin tumours often requires biopsy and histopathological examination to differentiate benign lesions such as seborrhoeic keratoses or melanocytic naevi from premalignant and malignant lesions such as malignant melanoma. Particularly, to the untrained eye, any benign skin tumour-pigmented or nonpigmented-is easily mistaken for a malignant lesion. Qualified clinical evaluation is paramount in order to reduce the frequency of unwarranted skin biopsies. Read More

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http://dx.doi.org/10.1155/2017/2414569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547714PMC
July 2017
15 Reads

Vulvar Neoplasms, Benign and Malignant.

Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352

Bethesda Dermpath Laboratory, 1730 Elton Road, Suite 11, Silver Spring, MD 20903, USA; Anne Arundel Dermatology, Towson, MD 21204, USA; Pathology, Johns Hopkins University, 4940 Bayview Medical Center, Eastern Avenue, Baltimore, MD 21224, USA. Electronic address:

Cutaneous vulvar neoplasms are commonly encountered at gynecology visits, with 2% of women having a benign vulvar melanocytic nevus and 10% to 12% of nevi being vulvar. High-grade squamous intraepithelial lesions (vulvar intraepithelial neoplasia 2 or 3) occurs in 5 per 100,000 women, with increasing incidence in the past 30 years. The recognition of these lesions and differentiation between benign, premalignant, and malignant stages are crucial for adequate diagnosis, clinical monitoring, and treatment. Read More

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http://dx.doi.org/10.1016/j.ogc.2017.04.002DOI Listing
September 2017
48 Reads

Urologic Dermatology: a Review.

Curr Urol Rep 2017 Aug;18(8):62

Virginia Mason Medical Center, Seattle, WA, USA.

Purpose Of Review: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic. Read More

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http://dx.doi.org/10.1007/s11934-017-0712-9DOI Listing
August 2017
84 Reads

A Rare Case of Intravesical Angiomyofibroblastoma.

Urology 2017 Aug 11;106:e15-e18. Epub 2017 May 11.

Department of Pathology, Ekopath Metropolis Lab Services Pvt. Ltd., Guwahati, Assam, India.

Objective: To study the first reported case of intravesical angiomyofibroblastoma (AMFB). AMFB is an uncommon benign mesenchymal lesion, mostly described in the lower female genital tract, especially in the vulva and less commonly in the vagina. It is rarely seen in the male genital tract. Read More

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http://dx.doi.org/10.1016/j.urology.2017.05.008DOI Listing
August 2017
25 Reads

Bilateral Giant Fibroepithelial Labial Mass: A Case Report.

J Obstet Gynaecol Can 2017 Jul 6;39(7):564-566. Epub 2017 May 6.

Sir Sanusi Specialist Hospital, Kano, Nigeria.

Background: Fibro-epithelial polyps are benign soft tissue lesions that occur in a wide variety of sites, including the lower female genital tract. They exhibit a wide range of morphologic appearances and can be misinterpreted as malignant. These polyps therefore pose adiagnostic challenge to both the clinician and the pathologist. Read More

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http://dx.doi.org/10.1016/j.jogc.2017.02.008DOI Listing
July 2017
17 Reads

Study of Selected BRCA1, BRCA2, and PIK3CA Mutations in Benign and Malignant Lesions of Anogenital Mammary-Like Glands.

Am J Dermatopathol 2017 May;39(5):358-362

*Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint Petersburg, Russia; †Department of Pathology, Medical Faculty, Saint-Petersburg State University, Saint-Petersburg, Russia; ‡Department of Pathology, Saint-Petersburg Medico-Social Institute, Saint Petersburg, Russia; Departments of §Pathology, and ¶Tumor Growth Biology, Petrov's Research Institute of Oncology, Saint Petersburg, Russia; ‖Department of Medical Genetics, Saint Petersburg Pediatric Medical University, Saint Petersburg, Russia; **Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; and ††Bioptical Laboratory, Pilsen, Czech Republic.

Anogenital mammary-like glands (AGMLGs) are nowadays considered a normal component of the anogenital area. Lesions involving AGMLGs are histopathologically very similar to their mammary counterparts, but the information on molecular biological mechanisms in these vulvar/perianal tumors is scarce. Mutations in the PI3K-AKT cascade have been found in hidradenoma papilliferum. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000725DOI Listing
May 2017
61 Reads

Label-Free Imaging of Female Genital Tract Melanocytic Lesions With Pump-Probe Microscopy: A Promising Diagnostic Tool.

J Low Genit Tract Dis 2017 Apr;21(2):137-144

1Department of Chemistry, Duke University, Durham, NC; 2Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA; and 3Department of Pathology, Duke University Medical Center, Durham, NC.

Objectives: Melanomas of the female genital tract present a unique clinical challenge. Not only are these lesions in an anatomically sensitive area, but also they tend to be multifocal and have high recurrence rates. Furthermore, several benign melanocytic proliferations resemble early-stage melanoma clinically and/or histopathologically. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365357PMC
April 2017
29 Reads

Vegas (Verruciform Genital-Associated) Xanthoma: A Comprehensive Literature Review.

Dermatol Ther (Heidelb) 2017 Mar 15;7(1):65-79. Epub 2016 Nov 15.

Department of Dermatology, University of California San Diego, La Jolla, CA, USA.

Introduction: Verruciform xanthoma is a wart-like benign lesion. The classic histologic appearance consists of foamy histiocytes within elongated dermal papillae and epithelial acanthosis. The lesion most commonly occurs in the oral cavity, but has been reported in extra-oral sites such as the penis, scrotum, and vulva. Read More

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http://dx.doi.org/10.1007/s13555-016-0155-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336425PMC
March 2017
23 Reads

Extramammary Paget Disease of the Vulva - Case Report.

Rev Bras Ginecol Obstet 2016 Oct 10;38(10):524-528. Epub 2016 Nov 10.

Department of Gynecology and Obstetrics, Health Sciences Center, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

Extramammary Paget disease (EPD) is a rare malign neoplasm that may affect the vulva and has manifestations common to benign diseases such as itching, pain and eczema. This leads to delay in diagnosis and consequent worse prognosis. The definitive diagnosis is obtained by biopsy of the vulva, which shows Paget cells. Read More

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http://dx.doi.org/10.1055/s-0036-1593884DOI Listing
October 2016
42 Reads

Giant Condyloma (Buschke-Loewenstein Tumor) in a 16-year-old Patient: Case Report.

Rev Bras Ginecol Obstet 2016 Sep 27;38(9):471-476. Epub 2016 Oct 27.

Gynecology and Obstetrics Department, Ribeirão Preto Faculty of Medicine, USP, Ribeirão Preto, SP, Brazil.

The Buschke-Loewenstein tumor is characterized by excessive growth of verrucous lesions on the genitals and/or perianal region. It is considered benign despite the high rate of recurrence and the possibility of malignant transformation. It is commonly associated with subtypes 6 and 11 of the human papillomavirus (HPV), and host's immunity plays an important role in the development of the disease. Read More

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http://dx.doi.org/10.1055/s-0036-1593776DOI Listing
September 2016
37 Reads

Angioqueratomas de fordyce múltiplos de vulva associados à cirrose hepática.

Dermatol Online J 2016 05 15;22(5). Epub 2016 May 15.

Setor de Dermatologia da Universidade Federal Fluminense.

Fordyce angiokeratoma is a benign skin neoplasm, characterized by erythematous-violet keratotic papules with mamillated surface, which follows a chronic and minimally symptomatic course. However, symptoms can be related such as itching, burning, bleeding, dyspareunia; aesthetic and social concerns may prompt request for treatment. The condition mainly affects men and usually occurs in the scrotum, but rarely may occur in women. Read More

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May 2016
52 Reads

Intravascular papillary endothelial hyperplasia of the vulva: report of a patient with Masson tumor of the vulva and literature review.

Dermatol Online J 2016 May 15;22(5). Epub 2016 May 15.

University of Nevada School of Medicine.

Background: Intravascular papillary endothelial hyperplasia -- also known as Masson tumor -- is a rare, benign vascular condition that manifests on the skin as a firm, blue-black colored nodule or papule. Lesions range in size from 0.25 to 5 centimeters in diameter and may be tender or painless. Read More

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May 2016
17 Reads

Vulvar granular cell tumor.

Indian J Pathol Microbiol 2016 Jul-Sep;59(3):389-91

Department of Pathology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.

Granular cell tumors (GCTs) are rare and approximately half of the all lesions arise from head and neck, especially from the tongue. However, they are rarely seen in the vulva. They can occur in patients of any age, but peak age incidence is in the fourth to sixth decades. Read More

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http://dx.doi.org/10.4103/0377-4929.188134DOI Listing
March 2017
59 Reads

Cellular angiofibroma of the vulva: a poorly known entity, a case report and literature review.

BMC Clin Pathol 2016 4;16. Epub 2016 Jun 4.

Department of Pathology, Children's Hospital Faculty of Medicine and Pharmacy, Mohammed V University Ibn Sina University Hospital, Rabat, Morocco.

Background: Cellular angiofibroma represents a newly described, site specific tumor. Histologically, CAF is a benign mesenchymal neoplasm characterized by two principal components: bland spindle cells and prominent small to medium-sized vessels with mural hyalinization. The indolent nature of the lesion is underscored by the uniformity of its constituent stromal cells, and their lack of nuclear atypia. Read More

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http://dx.doi.org/10.1186/s12907-016-0030-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893283PMC
June 2016
27 Reads