331 results match your criteria Benign Vulvar Lesions


Laparoscopic management of a large urethral leiomyoma.

Int Urogynecol J 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, University of Brescia, Brescia, Italy.

Introduction And Hypothesis: A 42-year-old female presented with a 12-cm mass bulging the anterior vaginal wall and causing urgency urinary incontinence and bulk symptoms.

Methods: Imaging showed a tumor originating from the dorsal and cranial part of the urethra and developing in the vesicouterine space and vesicovaginal septum, dislocating the bladder ventrally and the uterus cranial-dorsally.

Results: Tranvaginal biopsy showed a benign leiomyoma. Read More

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http://dx.doi.org/10.1007/s00192-019-03889-xDOI Listing
February 2019

Acquired angiokeratomas of the vulva.

Indian J Sex Transm Dis AIDS 2018 Jul-Dec;39(2):136-138

Department of Dermatology, Dr. D. Y. Patil Medical College and Hospital, Pune, Maharashtra, India.

Angiokeratomas are benign cutaneous lesions consisting of numerous ectatic blood vessels present in the superficial dermis and usually involving the scrotum. Although usually asymptomatic, they may be complicated by sporadic or profuse bleeding. We report the development of multiple vulvar angiokeratomas in a 40-year-old female after undergoing a perineoplasty successfully treated with electrocautery. Read More

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http://www.ijstd.org/text.asp?2018/39/2/136/247087
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http://dx.doi.org/10.4103/ijstd.IJSTD_50_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298145PMC
January 2019
5 Reads

Recurrent, nodular lesions over the vulva: A diagnostic challenge.

Indian J Sex Transm Dis AIDS 2018 Jul-Dec;39(2):124-126

Department of Dermatology, Father Muller Medical College, Mangalore, Karnataka, India.

Angiokeratomas are benign tumors characterized by proliferation and dilatation of blood vessels in the upper dermis. They are divided into widespread and localized forms. The localized forms are further classified as angiokeratoma of Fordyce, angiokeratoma circumscriptum neviforme, circumscribed angiokeratoma, and angiokeratoma of Mibelli, of which angiokeratoma of Fordyce is the most common. Read More

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http://dx.doi.org/10.4103/ijstd.IJSTD_101_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298154PMC
January 2019
1 Read

Distinction of Condylomata Acuminata from Vulvar Vestibular Papules or Pearly Penile Papules Using Ki-67 Immunostaining.

J Cutan Med Surg 2018 Dec 17:1203475418819992. Epub 2018 Dec 17.

1 Departments of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Background:: Ki-67 is an immunohistochemical stain used as a nuclear proliferation marker. It is nonspecific, and is expressed in all active phases of the cell cycle. Vulvar vestibular papules in women and pearly penile papules in men are benign fibrous papules on the genitals, are noninfectious, and do not require treatment. Read More

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http://dx.doi.org/10.1177/1203475418819992DOI Listing
December 2018
5 Reads

Adaptation of Alpha-Papillomavirus over Millennia.

Acta Cytol 2018 Dec 13:1-3. Epub 2018 Dec 13.

Papillomaviruses (PVs) are a group of small DNA viruses that, with around 350 million years of evolution, acquired the capacity of infecting a broad range of vertebrates, including humans. To date, more than 300 PV types have been isolated. Viruses that have a long common evolutionary history with their host typically cause unapparent infections. Read More

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https://www.karger.com/Article/FullText/492658
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http://dx.doi.org/10.1159/000492658DOI Listing
December 2018
10 Reads

Multiple Epidermolytic Acanthomas: Rare Vulval Lesions Which May be Mistaken for Viral Warts.

Int J Gynecol Pathol 2018 Nov 21. Epub 2018 Nov 21.

Departments of Pathology (S.I., A.K., W.G.M.) Dermatology (S.H.), Belfast Health and Social Care Trust Belfast Skin Clinic (P.M.) Centre for Medical Education, Queen's University (J.H.), Belfast Department of Pathology, Southmead Hospital, Bristol (K.M.) Department of Pathology, Antrim Area Hospital, Antrim, UK (J.J.).

Epidermolytic acanthoma is a rare benign lesion that most often presents as a solitary or multiple small papular lesions on the trunk, face, limbs or external male genitalia. Only a small number of cases have been reported occurring on the vulva and clinically and histologically they may mimic and be misdiagnosed as viral warts. We report 2 cases of multiple epidermolytic acanthomas localized to the vulva. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000570DOI Listing
November 2018
13 Reads

A Case Report of Scrotal Rejuvenation: Laser Treatment of Angiokeratomas of the Scrotum.

Authors:
Philip R Cohen

Dermatol Ther (Heidelb) 2018 Nov 26. Epub 2018 Nov 26.

San Diego Family Dermatology, National City, CA, USA.

Scrotal rejuvenation encompasses not only the functional quality but also the aesthetic appearance of the scrotum. It includes medical therapy and procedural interventions to improve scrotal conditions that require morphologic restoration and/or aesthetic alteration. Rejuvenation of the scrotum may be appropriate for aging-related and non-aging-related changes concerning the hair (alopecia and hypertrichosis), the morphology (laxity and wrinkles), and/or the vascularity (angiokeratoma) of the scrotum. Read More

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http://link.springer.com/10.1007/s13555-018-0272-z
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http://dx.doi.org/10.1007/s13555-018-0272-zDOI Listing
November 2018
6 Reads

Melanocytic lesions - Staying out of trouble.

Authors:
Thomas Brenn

Ann Diagn Pathol 2018 Dec 27;37:91-102. Epub 2018 Sep 27.

Department of Pathology & Laboratory Medicine, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary, AB T2L 2K8, Canada; Department of Medicine, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary, AB T2L 2K8, Canada; The Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary AB T2L 2K8, Canada; Department of Pathology, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, United Kingdom. Electronic address:

The diagnosis of melanocytic tumors is notoriously difficult and represents one of the most challenging areas in surgical pathology associated with significant risk for litigation. One reason is the wide morphologic spectrum of melanocytic tumors and the fact that many histological features are shared by both benign melanocytic nevi and melanoma. Awareness of the many morphologic variations and variants of nevi and melanoma, their clinical setting, immunohistochemical phenotype and genetic profile is necessary for the correct diagnosis. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.010DOI Listing
December 2018
5 Reads

Granular cell tumor: A report of three cases and review of literature.

Cancer Biomark 2018 ;23(2):173-178

Department of Obstetrics and Gynecology, The Hongqi Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157000, Heilongjiang, China.

Objective: In order to improve the understanding of granular cell tumor and avoid missing the best time of treatment, we report three patients with rare granular cell tumors admitted to our hospital in the past 10 years.

Methods: The characteristics, methods of treatment, postoperative pathological results and follow-up results of three cases of granular cell tumor were analyzed; and literatures related to granular cell tumors were reviewed.

Results: All patients underwent surgical treatment, and the excised lesions were sent to the laboratory for testing. Read More

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/CBM-170556DOI Listing
February 2019
5 Reads

Detection of bovine papillomavirus type 2 DNA in calf conjunctival myofibroblastoma.

J Vet Med Sci 2018 Nov 30;80(10):1544-1548. Epub 2018 Aug 30.

Hokkaido Research Station, National Institute of Animal Health, National Agriculture and Research Organization, 4 Hitsujigaoka, Toyohira, Sapporo, Hokkaido 062-0045, Japan.

An 8-month-old male Japanese Black calf was referred for the evaluation of a slow-growing conjunctival mass in the right eye. A superficial keratectomy was performed followed by recurrence on two occasions. No metastases were found in surrounding tissues. Read More

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http://dx.doi.org/10.1292/jvms.18-0341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207528PMC
November 2018
17 Reads

Evaluation of large clinically atypical vulvar pigmentation with RCM: atypical melanosis or early melanoma?

J Eur Acad Dermatol Venereol 2019 Jan 12;33(1):84-92. Epub 2018 Jul 12.

Dermatology Department, Centre Hospitalier de Lyon Sud, Hospices civils de Lyon, Université Claude Bernard Lyon 1, Pierre Bénite, France.

Background: Vulvar melanosis can occasionally be clinically challenging by mimicking an early melanoma.

Objective: To report our experience of initial evaluation and follow-up in this peculiar subset of vulvar melanosis using reflectance confocal microscopy (RCM).

Methods: We retrospectively evaluated 18 consecutive cases referred for atypical vulvar pigmentation or for which melanoma was considered and that underwent both RCM examination and histopathological assessment. Read More

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http://dx.doi.org/10.1111/jdv.15141DOI Listing
January 2019
14 Reads

Large Vaginal Varicosities in the Setting of Pregnancy without Known Hepatic or Vascular Risks: A Case Report and Review of the Literature.

Case Rep Obstet Gynecol 2018 22;2018:2394695. Epub 2018 Jan 22.

School of Medicine, Loma Linda University, Loma Linda, CA, USA.

Pregnancy may cause the onset of vaginal or vulvar varicosities that may be a concern for hemorrhage risk during childbirth. A 38-year-old female G4P1112 at 34 weeks and 1 day was referred to an outpatient OB/Gyn clinic for evaluation of a large vaginal mass. The referring provider had concern for malignancy. Read More

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http://dx.doi.org/10.1155/2018/2394695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827883PMC
January 2018
4 Reads

Ultrasonography of benign vulvar lesions.

Ultrasonography 2018 Oct 13;37(4):355-360. Epub 2018 Feb 13.

Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong.

With the increasing applications of ultrasonography in the field of dermatology, this imaging modality can be extended to identify and characterize common vulvar lesions, with a particular focus on their location, size, vascularity, and content. This pictorial essay provides an introduction to vulvar ultrasonography, including technical considerations, ultrasonographic anatomy, and the ultrasonographic appearances of some vulvar conditions. Read More

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http://dx.doi.org/10.14366/usg.18001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177693PMC
October 2018
4 Reads

Pediatric Granular Cell Tumors of the Vulva: A Report of 4 Cases and a Review of the Literature.

J Pediatr Adolesc Gynecol 2018 Jun 3;31(3):311-314. Epub 2018 Jan 3.

Department of Gynecology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts.

Background: Granular cell tumors (GCTs) are rare soft tissue lesions that can involve the female genital tract, including the vulva. Although malignant tumors are aggressive and uncommon, benign and atypical lesions still have associated risks, including recurrence and multisite development.

Cases: Four cases of pediatric vulvar GCT are presented, including 1 atypical and 3 benign tumors. Read More

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http://dx.doi.org/10.1016/j.jpag.2017.12.010DOI Listing
June 2018
13 Reads

Comparison of F-FDG PET/MRI and MRI alone for whole-body staging and potential impact on therapeutic management of women with suspected recurrent pelvic cancer: a follow-up study.

Eur J Nucl Med Mol Imaging 2018 04 21;45(4):622-629. Epub 2017 Nov 21.

Medical Faculty, Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, D-45147, Essen, Germany.

Purpose: To evaluate the diagnostic performance of F-FDG PET/MRI for whole-body staging and potential changes in therapeutic management of women with suspected recurrent pelvic cancer in comparison with MRI alone.

Methods: Seventy-one consecutive women (54 ± 13 years, range: 25-80 years) with suspected recurrence of cervical (32), ovarian (26), endometrial (7), vulvar (4), and vaginal (2) cancer underwent PET/MRI including a diagnostic contrast-enhanced MRI protocol. PET/MRI and MRI datasets were separately evaluated regarding lesion count, localization, categorization (benign/malignant), and diagnostic confidence (3-point scale; 1-3) by two physicians. Read More

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http://dx.doi.org/10.1007/s00259-017-3881-3DOI Listing
April 2018
16 Reads

Vulvar Nodules: A Rare Presentation of Mastocytosis.

J Pediatr Adolesc Gynecol 2018 Apr 21;31(2):156-157. Epub 2017 Nov 21.

Department of Obstetrics and Gynecology, Division of Pediatric and Adolescent Gynecology, UT Southwestern Medical Center, Children's Health, Dallas, Texas.

Background: Mastocytosis is a rare benign disorder characterized by the finding of mast cells in the skin and other organs, occurring in adult as well as pediatric age groups. The cutaneous form is the most common presentation in childhood and is rarely located on the vulva.

Case: A 9-year-old prepubertal girl presented with bilateral vulvar nodules found incidentally by her pediatrician. Read More

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http://dx.doi.org/10.1016/j.jpag.2017.11.006DOI Listing
April 2018
10 Reads

Nodular Hyperplasia of the Bartholin Gland, A Benign Mimicker of Aggressive Angiomyxoma: A Case Series and Literature Review.

Int J Gynecol Pathol 2018 Nov;37(6):554-558

Department of Pathology and Microbiology (Y.A.T.), University of Nebraska Medical Center, Omaha, Nebraska; Department of Pathology and Laboratory Medicine (Y.A.T., W.D.L., S.E.S.), The Warren Alpert Medical School of Brown University and Women & Infants Hospital, Providence, Rhode Island.

Nodular hyperplasia (NH) of the Bartholin gland is an exceedingly rare benign solid lesion of the female genital tract that can mimic the Bartholin gland cyst clinically. The histologic criteria for NH were established in 1998 by Koenig and Tavassoli. In this case series, we describe 4 cases of NH from Women and Infants Hospital in Rhode Island. Read More

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http://Insights.ovid.com/crossref?an=00004347-900000000-9925
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http://dx.doi.org/10.1097/PGP.0000000000000456DOI Listing
November 2018
13 Reads

Clinician's Update on the Benign, Premalignant, and Malignant Skin Tumours of the Vulva: The Dermatologist's View.

Int Sch Res Notices 2017 25;2017:2414569. Epub 2017 Jul 25.

Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.

Correct and rapid diagnosis of skin tumours often requires biopsy and histopathological examination to differentiate benign lesions such as seborrhoeic keratoses or melanocytic naevi from premalignant and malignant lesions such as malignant melanoma. Particularly, to the untrained eye, any benign skin tumour-pigmented or nonpigmented-is easily mistaken for a malignant lesion. Qualified clinical evaluation is paramount in order to reduce the frequency of unwarranted skin biopsies. Read More

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http://dx.doi.org/10.1155/2017/2414569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547714PMC
July 2017
6 Reads

Vulvar Neoplasms, Benign and Malignant.

Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352

Bethesda Dermpath Laboratory, 1730 Elton Road, Suite 11, Silver Spring, MD 20903, USA; Anne Arundel Dermatology, Towson, MD 21204, USA; Pathology, Johns Hopkins University, 4940 Bayview Medical Center, Eastern Avenue, Baltimore, MD 21224, USA. Electronic address:

Cutaneous vulvar neoplasms are commonly encountered at gynecology visits, with 2% of women having a benign vulvar melanocytic nevus and 10% to 12% of nevi being vulvar. High-grade squamous intraepithelial lesions (vulvar intraepithelial neoplasia 2 or 3) occurs in 5 per 100,000 women, with increasing incidence in the past 30 years. The recognition of these lesions and differentiation between benign, premalignant, and malignant stages are crucial for adequate diagnosis, clinical monitoring, and treatment. Read More

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http://dx.doi.org/10.1016/j.ogc.2017.04.002DOI Listing
September 2017
22 Reads

Urologic Dermatology: a Review.

Curr Urol Rep 2017 Aug;18(8):62

Virginia Mason Medical Center, Seattle, WA, USA.

Purpose Of Review: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic. Read More

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http://dx.doi.org/10.1007/s11934-017-0712-9DOI Listing
August 2017
40 Reads

A Rare Case of Intravesical Angiomyofibroblastoma.

Urology 2017 Aug 11;106:e15-e18. Epub 2017 May 11.

Department of Pathology, Ekopath Metropolis Lab Services Pvt. Ltd., Guwahati, Assam, India.

Objective: To study the first reported case of intravesical angiomyofibroblastoma (AMFB). AMFB is an uncommon benign mesenchymal lesion, mostly described in the lower female genital tract, especially in the vulva and less commonly in the vagina. It is rarely seen in the male genital tract. Read More

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http://dx.doi.org/10.1016/j.urology.2017.05.008DOI Listing
August 2017
14 Reads

Study of Selected BRCA1, BRCA2, and PIK3CA Mutations in Benign and Malignant Lesions of Anogenital Mammary-Like Glands.

Am J Dermatopathol 2017 May;39(5):358-362

*Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint Petersburg, Russia; †Department of Pathology, Medical Faculty, Saint-Petersburg State University, Saint-Petersburg, Russia; ‡Department of Pathology, Saint-Petersburg Medico-Social Institute, Saint Petersburg, Russia; Departments of §Pathology, and ¶Tumor Growth Biology, Petrov's Research Institute of Oncology, Saint Petersburg, Russia; ‖Department of Medical Genetics, Saint Petersburg Pediatric Medical University, Saint Petersburg, Russia; **Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; and ††Bioptical Laboratory, Pilsen, Czech Republic.

Anogenital mammary-like glands (AGMLGs) are nowadays considered a normal component of the anogenital area. Lesions involving AGMLGs are histopathologically very similar to their mammary counterparts, but the information on molecular biological mechanisms in these vulvar/perianal tumors is scarce. Mutations in the PI3K-AKT cascade have been found in hidradenoma papilliferum. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000725DOI Listing
May 2017
29 Reads

Label-Free Imaging of Female Genital Tract Melanocytic Lesions With Pump-Probe Microscopy: A Promising Diagnostic Tool.

J Low Genit Tract Dis 2017 Apr;21(2):137-144

1Department of Chemistry, Duke University, Durham, NC; 2Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA; and 3Department of Pathology, Duke University Medical Center, Durham, NC.

Objectives: Melanomas of the female genital tract present a unique clinical challenge. Not only are these lesions in an anatomically sensitive area, but also they tend to be multifocal and have high recurrence rates. Furthermore, several benign melanocytic proliferations resemble early-stage melanoma clinically and/or histopathologically. Read More

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http://Insights.ovid.com/crossref?an=00128360-201704000-0001
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http://dx.doi.org/10.1097/LGT.0000000000000290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365357PMC
April 2017
20 Reads

Vegas (Verruciform Genital-Associated) Xanthoma: A Comprehensive Literature Review.

Dermatol Ther (Heidelb) 2017 Mar 15;7(1):65-79. Epub 2016 Nov 15.

Department of Dermatology, University of California San Diego, La Jolla, CA, USA.

Introduction: Verruciform xanthoma is a wart-like benign lesion. The classic histologic appearance consists of foamy histiocytes within elongated dermal papillae and epithelial acanthosis. The lesion most commonly occurs in the oral cavity, but has been reported in extra-oral sites such as the penis, scrotum, and vulva. Read More

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http://dx.doi.org/10.1007/s13555-016-0155-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336425PMC
March 2017
9 Reads

Extramammary Paget Disease of the Vulva - Case Report.

Rev Bras Ginecol Obstet 2016 Oct 10;38(10):524-528. Epub 2016 Nov 10.

Department of Gynecology and Obstetrics, Health Sciences Center, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

Extramammary Paget disease (EPD) is a rare malign neoplasm that may affect the vulva and has manifestations common to benign diseases such as itching, pain and eczema. This leads to delay in diagnosis and consequent worse prognosis. The definitive diagnosis is obtained by biopsy of the vulva, which shows Paget cells. Read More

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http://dx.doi.org/10.1055/s-0036-1593884DOI Listing
October 2016
22 Reads

Giant Condyloma (Buschke-Loewenstein Tumor) in a 16-year-old Patient: Case Report.

Rev Bras Ginecol Obstet 2016 Sep 27;38(9):471-476. Epub 2016 Oct 27.

Gynecology and Obstetrics Department, Ribeirão Preto Faculty of Medicine, USP, Ribeirão Preto, SP, Brazil.

The Buschke-Loewenstein tumor is characterized by excessive growth of verrucous lesions on the genitals and/or perianal region. It is considered benign despite the high rate of recurrence and the possibility of malignant transformation. It is commonly associated with subtypes 6 and 11 of the human papillomavirus (HPV), and host's immunity plays an important role in the development of the disease. Read More

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http://dx.doi.org/10.1055/s-0036-1593776DOI Listing
September 2016
11 Reads

Angioqueratomas de fordyce múltiplos de vulva associados à cirrose hepática.

Dermatol Online J 2016 05 15;22(5). Epub 2016 May 15.

Setor de Dermatologia da Universidade Federal Fluminense.

Fordyce angiokeratoma is a benign skin neoplasm, characterized by erythematous-violet keratotic papules with mamillated surface, which follows a chronic and minimally symptomatic course. However, symptoms can be related such as itching, burning, bleeding, dyspareunia; aesthetic and social concerns may prompt request for treatment. The condition mainly affects men and usually occurs in the scrotum, but rarely may occur in women. Read More

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May 2016
35 Reads

Intravascular papillary endothelial hyperplasia of the vulva: report of a patient with Masson tumor of the vulva and literature review.

Dermatol Online J 2016 May 15;22(5). Epub 2016 May 15.

University of Nevada School of Medicine.

Background: Intravascular papillary endothelial hyperplasia -- also known as Masson tumor -- is a rare, benign vascular condition that manifests on the skin as a firm, blue-black colored nodule or papule. Lesions range in size from 0.25 to 5 centimeters in diameter and may be tender or painless. Read More

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May 2016
8 Reads

Vulvar granular cell tumor.

Indian J Pathol Microbiol 2016 Jul-Sep;59(3):389-91

Department of Pathology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.

Granular cell tumors (GCTs) are rare and approximately half of the all lesions arise from head and neck, especially from the tongue. However, they are rarely seen in the vulva. They can occur in patients of any age, but peak age incidence is in the fourth to sixth decades. Read More

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http://dx.doi.org/10.4103/0377-4929.188134DOI Listing
March 2017
26 Reads

Cellular angiofibroma of the vulva: a poorly known entity, a case report and literature review.

BMC Clin Pathol 2016 4;16. Epub 2016 Jun 4.

Department of Pathology, Children's Hospital Faculty of Medicine and Pharmacy, Mohammed V University Ibn Sina University Hospital, Rabat, Morocco.

Background: Cellular angiofibroma represents a newly described, site specific tumor. Histologically, CAF is a benign mesenchymal neoplasm characterized by two principal components: bland spindle cells and prominent small to medium-sized vessels with mural hyalinization. The indolent nature of the lesion is underscored by the uniformity of its constituent stromal cells, and their lack of nuclear atypia. Read More

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http://dx.doi.org/10.1186/s12907-016-0030-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893283PMC
June 2016
15 Reads

Literature Review of Periclitoral Cysts in the Prepubertal Population.

J Pediatr Adolesc Gynecol 2016 Dec 27;29(6):558-561. Epub 2016 May 27.

Obstetrics and Gynecology, Pediatric Gynecology, University of Calgary, The Alberta Children's Hospital, Calgary, Alberta, Canada.

Study Objective: Clitoral cysts in the pediatric population are rare conditions that require careful evaluation. In this review of the literature we discuss the evaluation of clitoral abnormalities in the pediatric population, the development of clitoral cysts, and how to differentiate benign from malignant tumors. In addition, a summary of relevant cases of clitoral tumors in the literature are discussed. Read More

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http://dx.doi.org/10.1016/j.jpag.2016.05.005DOI Listing
December 2016
15 Reads

Syringoma: A clinicopathological study of 244 cases.

Ann Dermatol Venereol 2016 Aug-Sep;143(8-9):521-8. Epub 2016 Apr 21.

Clinique dermatologique, faculté de médecine, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France.

Background: Syringomas are benign tumours of the sweat glands, the most familiar clinical presentation of which is the presence of multiple lesions on the eyelids. The aim of our study was to determine the clinical and histological characteristics of a large series of patients and to examine anatomoclinical correlations.

Patients And Methods: This was a retrospective study conducted in all of the cases of syringoma analysed at the cutaneous histopathology laboratory in Strasbourg between 1970 and 2008. Read More

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http://dx.doi.org/10.1016/j.annder.2015.06.025DOI Listing
June 2017
2 Reads

Papillary urothelial carcinoma with squamous differentiation in association with human papilloma virus: case report and literature review.

Am J Clin Exp Urol 2016 28;4(1):12-6. Epub 2016 Jan 28.

Department of Pathology, York University School of MedicineNew York, NY 10010, USA; Department of Veterans Affairs New York Harbor Healthcare SystemNew York, NY 10010, USA.

Background: The human papilloma virus (HPV) is a carcinogen known for its strong association with cervical cancers and cervical lesions. It is also known to be associated with a variety of squamous cell carcinomas in other areas, such as the penis, vulva, anus and head and neck. However, the association with urothelial carcinoma remains controversial. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749403PMC
April 2016
17 Reads

[PAPILLOMAVIRUS INFECTION: PRINCIPLE CHARACTERISTICS, CLINICAL MANIFESTATIONS, VACCINE PROPHYLAXIS].

Zh Mikrobiol Epidemiol Immunobiol 2016 Jan-Feb(1):71-8

Papillomaviruses are a large and diverse group of viruses. It includes approximately 200 fully described types that have been detected in humans. Human papilloma viruses (HPV) are etiologic agents during various, benign and malignant lesions of mucous membrane and skin epithelium. Read More

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April 2016
5 Reads

The 2015 International Society for the Study of Vulvovaginal Disease (ISSVD) Terminology of Vulvar Squamous Intraepithelial Lesions.

Obstet Gynecol 2016 Feb;127(2):264-8

Departments of Obstetrics and Gynecology, Galilee Medical Center and Bar-Ilan University Faculty of Medicine, Nahariya, Israel, Chivasso Civic Hospital, Chivasso, and University of Turin, Turin, Italy, University of Michigan Health System, Ann Arbor, Michigan, and University of Iowa, Iowa City, Iowa; Jean Hailes Medical Center for Women, Monash, Australia; and Piedmont Pathology Associates, Hickory, North Carolina.

Objectives: The impact of terminology for vulvar intraepithelial lesions has been significant over the years, because it has affected diagnosis, treatment, and research. The introduction of the Lower Anogenital Squamous Terminology (LAST) in 2012 raised 2 concerns in relation to vulvar lesions: firstly, the absence of reference to "differentiated vulvar intraepithelial neoplasia" (differentiated VIN) could lead to its being overlooked by health care providers, despite its malignant potential. Secondly, including the term "low-grade squamous intraepithelial lesion" (LSIL) in LAST recreated the potential for overdiagnosis and overtreatment for benign, self-limiting lesions. Read More

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http://dx.doi.org/10.1097/AOG.0000000000001285DOI Listing
February 2016
54 Reads

Other Gynecologic Pathology in Endometrial Cancer Patients.

Asian Pac J Cancer Prev 2016 ;17(2):713-7

Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand E-mail :

Background: To evaluate the prevalence and features of other gynecologic or surgical lesions in endometrial cancer (EMC) patients.

Materials And Methods: Clinico-pathological data of EMC patients who were treated in the institution from 1995 to 2012 were collected. Data collected were age, stage of disease according to the FIGO 2009 criteria (FIGO), histopathology, tumor grade, adjuvant therapy, other gynecologic or surgical lesions, follow-up period, and living status. Read More

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January 2017
8 Reads

[The clinical features of primary or metastatic malignancies presenting with multiple lung cavities].

Zhonghua Jie He He Hu Xi Za Zhi 2016 Feb;39(2):88-92

Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Objective: To evaluate the clinical, radiological and pathological features of primary or metastatic malignancies presenting with multiple lung cavities.

Methods: A total of 38 cases met the inclusion criteria and had adequate imaging data for retrospective review between June 2006 and August 2013. There were 30 cases of primary lung cancer, and 8 cases of pulmonary metastasis including 6 gastrointestinal tract malignancies, 1 vulva malignancy and 1 scalp malignancy. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2016.02.003DOI Listing
February 2016
23 Reads

Hidradenoma Papilliferum: A Clinicopathologic Study of 264 Tumors From 261 Patients, With Emphasis on Mammary-Type Alterations.

Am J Dermatopathol 2016 Aug;38(8):598-607

*Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint-Petersburg, Russia; †Department of Pathology, Medical Faculty, Saint-Petersburg State University, Saint-Petersburg, Russia; ‡Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; §Bioptical Laboratory, Pilsen, Czech Republic; ¶PathWest Laboratory Medicine WA, QEII Medical Centre, Nedlands, Australia; ‖School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Australia; **PathWest Laboratory Medicine WA, King Edward Memorial Hospital, Perth, Australia; ††Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany; ‡‡Clinical Department of Dermatology and Venereology, Medical University Innsbruck, Innsbruck, Austria; §§Division of Dermatopathology, Department of Pathology, Medical College of Wisconsin, Milwaukee, WI; ¶¶Dermatopathology Institute, Zürich, Switzerland; ‖‖Department of Pathology, Institute for the Care of Mother and Child, Prague, Czech Republic; ***Department of Pathology, Petrov's Research Institute of Oncology, Saint-Petersburg, Russia; †††Unit of Anatomic Pathology, School of Biomedical Sciences, Etromapmacs Pole, Lesina (FG), Italy; ‡‡‡Cytopathos Laboratory, Bratislava, Slovak Republic; §§§Agel Laboratory of Pathology, Novy Jicin, Czech Republic; and ¶¶¶Department of Dermatology, Zurich University Hospital, Zurich, Switzerland.

Hidradenoma papilliferum (HP), also known as papillary hidradenoma, is the most common benign lesion of the female anogenital area derived from anogenital mammary-like glands (AGMLG). HP can be viewed conceptually as the cutaneous counterpart of mammary intraductal papilloma. The authors have studied 264 cases of HP, detailing various changes in the tumor and adjacent AGMLG, with emphasis on mammary-type alterations. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000495DOI Listing
August 2016
41 Reads

Aberrant promoter methylation of SH3GL2 gene in vulvar squamous cell carcinoma correlates with clinicopathological characteristics and HPV infection status.

Int J Clin Exp Pathol 2015 1;8(11):15442-7. Epub 2015 Nov 1.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University Shenyang 110004, China.

Objective: This study attempted to examine the methylation status of SH3GL2 gene in different types of human vulvar lesions and its correlation with clinicopathological parameters.

Methods: Immunohistochemical analysis was used to identify the expression status of SH3GL2 in vulvar squamous cell carcinoma (VSCC), vulvar intraepithelial neoplasia (VIN) and benign vulvar squamous epithelium tissues. Bisulfite genomic sequencing method was used to detect methylation status of the SH3GL2 gene. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713698PMC
October 2016
5 Reads

HPV-Associated Atypical Mitotic Figures in Squamous Intraepithelial Lesions of the Lower Female Genital Tract.

J Low Genit Tract Dis 2016 Apr;20(2):165-8

1Anatomical Pathology, Pathology North, Hunter New England, New Lambton and Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia; and 2Department of Pathology, Norvic International Hospital, Kathmandu, Nepal.

Objectives: Atypical mitoses with rod and dot-shaped extra pieces of chromosomes separate to the main spindle are commonly seen in HPV-associated intraepithelial lesions. To determine the reproducibility and correlation of HPV-associated atypical mitoses (HAM) with histological diagnosis and p16 status, we performed a retrospective study.

Methods: A total of 100 consecutive cervical biopsies, 10 vulvar HSIL (usual VIN), 10 differentiated VIN, 10 vulvar condylomata, 5 normal proliferative endometrial, and 5 normal ovarian follicles were assessed. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000172DOI Listing
April 2016
5 Reads

Syringocystadenoma papilliferum in an unusual location.

An Bras Dermatol 2015 Nov-Dec;90(6):900-2

Universidade Federal do Pará, Belém, PA, Brazil.

Syringocystadenoma papilliferum is a rare benign hamartomatous adnexal tumor of the apocrine or eccrine sweat glands. Most patients present a solitary lesion in the head and neck region. Presentation outside the head and neck region is even more uncommon. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20153862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689083PMC
June 2016
5 Reads

Angiosarcoma of the Vulva: A Case Report.

J Low Genit Tract Dis 2016 Jan;20(1):e6-7

1Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; 2Department of Anatomic Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 3Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; 4Department of Gynecology, Women's College Hospital, Toronto, Ontario, Canada; and 5Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.

This case illustrates that a very benign looking lesion can be an aggressive cancer. Vulvar lesions need a biopsy to rule out malignancy if they are painful, progressing in size, or changing in appearance. Read More

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http://pdfs.journals.lww.com/jlgtd/2016/01000/Angiosarcoma_o
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http://dx.doi.org/10.1097/LGT.0000000000000171DOI Listing
January 2016
7 Reads

The 2015 International Society for the Study of Vulvovaginal Disease (ISSVD) Terminology of Vulvar Squamous Intraepithelial Lesions.

J Low Genit Tract Dis 2016 Jan;20(1):11-4

From the 1Department of Obstetrics and Gynecology, Galilee Medical Center and Bar-Ilan University Faculty of Medicine, Nahariya, Israel; 2Department of Obstetrics and Gynecology, Chivasso Civic Hospital, Chivasso, Turin, Italy; 3Department of Obstetrics and Gynecology, University of Michigan Health System, Ann Arbor, MI; 4Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA; 5Department of Obstetrics and Gynecology, University of Turin, Turin, Italy; 6Jean Hailes Medical Center for Women, Monash, Australia; and 7Piedmont Pathology Associates, Hickory, NC.

Objectives: The impact of terminology for vulvar intraepithelial lesions has been significant over the years, because it has affected diagnosis, treatment, and research. The introduction of the Lower Anogenital Squamous Terminology (LAST) in 2012 raised 2 concerns in relation to vulvar lesions: firstly, the absence of reference to "differentiated vulvar intraepithelial neoplasia" (differentiated VIN) could lead to its being overlooked by health care providers, despite its malignant potential. Secondly, including the term "low-grade squamous intraepithelial lesion" (LSIL) in LAST recreated the potential for overdiagnosis and overtreatment for benign, self-limiting lesions. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000169DOI Listing
January 2016
72 Reads

Recent Developments in Non-HPV-related Adenocarcinomas of the Lower Female Genital Tract and Their Precursors.

Adv Anat Pathol 2016 Jan;23(1):58-69

Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.

Most adenocarcinomas in the lower female genital tract (cervix, vagina, vulva) arise in the cervix and are associated with high-risk human papillomavirus (HPV) infection. However, there is an emerging spectrum of non-HPV-related cervical adenocarcinomas, the most common of which is so-called gastric type. In this review, the concept of gastric-type cervical adenocarcinomas and their possible precursor lesions is covered, the precursor lesions still being poorly understood. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000095DOI Listing
January 2016
4 Reads

Ultrasound plays a key role in imaging and management of genital angiomyofibroblastoma: a case report.

J Med Case Rep 2015 Oct 28;9:248. Epub 2015 Oct 28.

Department of Obstetrics and Gynecology, Leipzig University, Liebigstrasse 20a, 04103, Leipzig, Germany.

Introduction: Angiomyofibroblastoma is a benign, rare mesenchymal tumor arising from the genital tract of both men and women and was first described by Fletcher and colleagues in 1992. The tumor needs to be distinguished from other, similar lesions, such as deep and superficial aggressive angiomyxoma and cellular angiofibroma, because aggressive angiomyxoma demands much more extensive treatment. The vast majority of angiomyofibroblastomas arise from the vulva and appear as solid cystic masses on ultrasound images. Read More

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http://dx.doi.org/10.1186/s13256-015-0715-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625571PMC
October 2015
5 Reads

Second-generation prophylactic HPV vaccines: current options and future strategies for vaccines development.

Minerva Med 2016 Feb 16;107(1):26-38. Epub 2015 Oct 16.

Obstetrics and Gynecology, St. Franziskus Hospital Münster, Germany -

Two vaccines focused on the prevention of HPV-related diseases have been introduced in the last decade, the quadrivalent vaccine Gardasil and the bivalent vaccine Cervarix. They are targeted to prevent precancerous and cancerous lesions not only of the cervix, but also of the vulva, vagina, anal and head-neck region. Furthermore, the protection of the quadrivalent vaccine Gardasil includes also genital warts and recurrent respiratory Papillomatosis, two benign conditions with high socio-economic impact. Read More

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http://www.agilvax.com/publications/TylerEtAlL2Review2014.pd
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February 2016
8 Reads

Verruciform Genital-Associated (Vegas) Xanthoma: report of a patient with verruciform xanthoma of the scrotum and literature review.

Dermatol Online J 2015 Aug 15;21(8). Epub 2015 Aug 15.

School of Allied Health Sciences, University of Nevada, Las Vegas.

Background: Verruciform xanthoma is a benign verrucous lesion characterized by epithelial acanthosis and lipid-laden foamy histiocytes in the connective tissue papillae. It typically presents as a papillomatous, polypoid, or sessile lesion. Verruciform xanthoma is most commonly observed within the oral cavity. Read More

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August 2015
8 Reads

Lymphangioma Circumscriptum: Clinicopathological Spectrum of 29 Cases.

J Coll Physicians Surg Pak 2015 Sep;25(9):658-61

Department of Pathology and Microbiology, The Aga Khan UniversityHospital, Karachi.

Objective: To describe the clinicopathological spectrum of Lymphangioma Circumscriptum (LC).

Study Design: Observational case series.

Place And Duration Of Study: Department of Pathology and Microbiology, AKUH, Karachi, from 2002 to 2012. Read More

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http://dx.doi.org/09.2015/JCPSP.658661DOI Listing
September 2015
6 Reads

Unilateral angiokeratoma of vulva: a rare clinic entity.

J Exp Ther Oncol 2015 ;11(1):71-3

The aim of this study is to present a very rare dermatologic condition of the vulva. Angiokeratoma is a benign dilation of ectatic thin-walled blood vessels and congested capillaries in the superficial dermal layer of skin. It occurs predominantly in men and extremely rare in women. Read More

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September 2015
15 Reads

Perineal reconstruction with biologic graft vulvoplasty for verrucous carcinoma treated by repeated vulvar excisions: a case report.

Rom J Morphol Embryol 2015 ;56(2):537-43

Department of Obstetrics and Gynecology, "Carol Davila" University of Medicine and Pharmacy, "St. Pantelimon" Emergency Clinical Hospital, Bucharest, Romania;

Vulvar neoplasia represents 5% of malignancies in female genital tract and 0.6% of all cancers in women. Although it is known to be a rare type of cancer, which occurs especially in elderly women, its incidence is increasing in young females because of its association with the human papillomavirus (HPV). Read More

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http://www.rjme.ro/archive/56/2/
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February 2016
29 Reads