3,434 results match your criteria Benign Skull Tumors


"Aggressive cranial Osteoblastoma of the parietotemporooccipital bone: a case report and review of literature with a special emphasis on recurrence/residue".

World Neurosurg 2020 Jun 19. Epub 2020 Jun 19.

Department of Neurosurgery, AIIMS, New Delhi 110029, India.

Osteoblastoma is a rare nonfibroblastic osteoid tissue forming primary bony tumor usually arising in the medullary cavity /diploic space of any bone. Calvarium is an extremely rare site of its origin. Clinically, two types of Osteoblastomas are noted: benign/conventional/typical and aggressive/high grade. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.093DOI Listing

Clinical findings in families with chordoma with and without T gene duplications and in patients with sporadic chordoma reported to the Surveillance, Epidemiology, and End Results program.

J Neurosurg 2020 Jun 19:1-10. Epub 2020 Jun 19.

1Division of Cancer Epidemiology & Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda.

Objective: To gain insight into the role of germline genetics in the development of chordoma, the authors evaluated data from 2 sets of patients with familial chordoma, those with and without a germline duplication of the T gene (T-dup+ vs T-dup-), which was previously identified as a susceptibility mechanism in some families. The authors then compared the patients with familial tumors to patients with sporadic chordoma in the US general population reported to the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program through 2015.

Methods: Evaluation of family members included review of personal and family medical history, physical and neurological examination, and pre- and postcontrast MRI of the skull base and spine. Read More

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http://dx.doi.org/10.3171/2020.4.JNS193505DOI Listing

Transnasal Transsphenoidal Approach for Pituitary Tumors: An ENT Perspective.

Indian J Otolaryngol Head Neck Surg 2020 Jun 11;72(2):239-246. Epub 2020 Feb 11.

Department of Neurosurgery, Army Hospital (Research & Referral), Delhi Cantt, 110010 India.

Endoscopic transnasal transsphenoidal (ETNTS) approach was first described in 1992 and is standard approach for the resection of benign pituitary adenomas. This prospective study aims in incidence and preoperative assessment of extent of the pituitary adenoma, peroperative findings of transnasal transsphenoidal excision, techniques of skull base repair, complications and its management in a tertiary centre. A prospective analysis from Jan 2017 to May 2019, of patients undergoing ETNTS approach of pituitary adenomas was made in terms of incidence in various age-groups, type of adenoma, operative findings including CSF leak, repair of the skull base defect, complications encountered and its management was done in a tertiary care centre and compared with the present literature. Read More

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http://dx.doi.org/10.1007/s12070-020-01803-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276463PMC

Treatment of patients with glomus jugulare tumours (GJT) and its subjective effect on quality of life (QoL) measures.

Am J Otolaryngol 2020 May 27:102559. Epub 2020 May 27.

Division of Neurosurgery, QEII Halifax Infirmary Site, 3rd Floor, 1796 Summer Street, Halifax, NS B3H 3A7, Canada; Maritime Lateral Skull Base Clinic: Divisions of Neurosurgery, OtolaryngologyHead & Neck Surgery and Department of Radiation Oncology, Dalhousie University, QEII Health Sciences Centre, 3rd floor Dickson Building, 5820 University Avenue, Halifax, NS B3H 1Y9, Canada. Electronic address:

Cerebellopontine angle (CPA) tumours account for 6-10% of intracranial tumours. The most common CPA tumours are vestibular schwannomas (VS), also known as acoustic neuromas, benign tumours of the vestibulocochlear nerve. Less common but symptomatic skull base lesions are glomus jugulare tumours (GJT), of which approximately 40% are identified as CPA tumours. Read More

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http://dx.doi.org/10.1016/j.amjoto.2020.102559DOI Listing

Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma.

Cancers (Basel) 2020 Jun 5;12(6). Epub 2020 Jun 5.

Jan and Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.

Background: Meningiomas constitute one-third of all primary brain tumors. Although typically benign, about 20% of these tumors recur despite surgery and radiation, and may ultimately prove fatal. There are currently no effective chemotherapies for meningioma. Read More

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http://dx.doi.org/10.3390/cancers12061478DOI Listing

Endoscopy-assisted transoral resection of a parapharyngeal space schwannoma without mandibular dissection.

Auris Nasus Larynx 2020 Jun 5. Epub 2020 Jun 5.

Department of Otorhinolaryngology, Sapporo Medical University School of Medicine, Minami 1-jo Nishi 16-chome, Chuo-ku, Sapporo, Hokkaido, 060-0061, Japan. Electronic address:

Of the schwannomas that arise from the parapharyngeal space, those in the high cervical region are particularly invasive, requiring mandibular dissection. Because these tumors are benign, however, excessive surgical invasion and postoperative neurological complications should be avoided. Postoperative dropout symptoms may be avoided by intracapsular extraction, including nerve integrity monitoring (NIM) and narrow-band imaging (NBI). Read More

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http://dx.doi.org/10.1016/j.anl.2020.04.012DOI Listing

Tumor-Induced Osteomalacia.

Calcif Tissue Int 2020 Jun 5. Epub 2020 Jun 5.

Skeletal Disorders and Mineral Homeostasis Section, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by tumoral production of fibroblast growth factor 23 (FGF23). The hallmark biochemical features include hypophosphatemia due to renal phosphate wasting, inappropriately normal or frankly low 1,25-dihydroxy-vitamin D, and inappropriately normal or elevated FGF23. TIO is caused by typically small, slow growing, benign phosphaturic mesenchymal tumors (PMTs) that are located almost anywhere in the body from the skull to the feet, in soft tissue or bone. Read More

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http://dx.doi.org/10.1007/s00223-020-00691-6DOI Listing

Landscape of immune cell gene expression is unique in predominantly WHO grade 1 skull base meningiomas when compared to convexity.

Sci Rep 2020 Jun 3;10(1):9065. Epub 2020 Jun 3.

Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, Toronto, ON, Canada.

Modulation of tumor microenvironment is an emerging frontier for new therapeutics. However in meningiomas, the most frequent adult brain tumor, the correlation of microenvironment with tumor phenotype is scarcely studied. We applied a variety of systems biology approaches to bulk tumor transcriptomics to explore the immune environments of both skull base and convexity (hemispheric) meningiomas. Read More

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http://dx.doi.org/10.1038/s41598-020-65365-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270140PMC

Epidermoid cyst in temple area with skull perforation.

Arch Craniofac Surg 2020 Apr 20;21(2):137-140. Epub 2020 Apr 20.

Department of Plastic and Reconstructive Surgery, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

Epidermoid cysts are benign tumors that account for approximately 1% of intracranial tumors. In very rare cases, temporally located extradural intradiploic epidermoid cysts can cause neurological symptoms and skull perforation. Herein, we report the case of a 34-year-old woman who underwent successful treatment of an epidermoid cyst in the temporal region accompanied by neurological symptoms. Read More

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http://dx.doi.org/10.7181/acfs.2019.00703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206461PMC

Prognostic impact of the "Sekhar grading system for cranial Chordomas" in patients treated with pencil beam scanning proton therapy: an institutional analysis.

Radiat Oncol 2020 May 6;15(1):96. Epub 2020 May 6.

Center for Proton Therapy, Paul Scherrer Institute, 5232 PSI West, Villigen, Switzerland.

Background: Skull base chordomas are rare and heterogeneously behaving tumors. Though still classified as benign they can grow rapidly, are locally aggressive, and have the potential to metastasize. To adapt the treatment to the specific needs of patients at higher risk of recurrence, a pre-proton therapy prognostic grading system would be useful. Read More

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http://dx.doi.org/10.1186/s13014-020-01547-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201750PMC
May 2020
2.546 Impact Factor

Acinic cell carcinoma of the parotid gland: from pathogenesis to management: a literature review.

Eur Arch Otorhinolaryngol 2020 May 4. Epub 2020 May 4.

Department of Otorhinolaryngology, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy.

Purpose: Acinic cell carcinoma (ACCs) is uncommon malignant epithelial neoplasm of the salivary glands; the most common presentation is a well-defined painless solid mass. Diagnosis of ACCs is frequently complicated, due to its similarity with benign tumors.

Methods: A review of the literature available on ACCs was carried out. Read More

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http://dx.doi.org/10.1007/s00405-020-05998-6DOI Listing

Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms.

Vet Comp Oncol 2020 Apr 30. Epub 2020 Apr 30.

Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, USA.

Tonsillar metastasis from distant primary tumours has not been described in dogs, and reports are rare in humans. The aims of this study were to determine whether tumour metastasis occurs to the canine palatine tonsils and evaluate whether afferent lymphatics drain to the palatine tonsils via skull indirect computed tomography lymphangiography (ICTL). Retrospective review of the diagnostic laboratory tonsillar histopathology submissions was performed. Read More

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http://dx.doi.org/10.1111/vco.12604DOI Listing

An Unusual Bump on the Head: Intracranial and Extracranial Cytokeratin-Positive Interstitial Reticular Cell Tumor.

World Neurosurg 2020 Apr 13;139:60-62. Epub 2020 Apr 13.

Department of Neurosurgery, University Hospital Basel, Basel, Switzerland.

Background: We describe a cytokeratin positive interstitial reticulum cell tumor (CPIRCT) as the cause of a large and defacing scalp tumor. Clinically these tumors manifest as progressive, painless swelling. Treatment usually consists of surgery with or without irradiation; chemotherapy is applied in metastatic disease. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.173DOI Listing

The Utility of 5-Aminolevulinic Acid for Microsurgical Resection of Meningiomas.

World Neurosurg 2020 Apr 6;139:343. Epub 2020 Apr 6.

Department of Neurological Surgery, Mayo Clinic, Phoenix, Arizona, USA; Department of Otolaryngology, Mayo Clinic, Phoenix, Arizona, USA; Department of Radiology, Mayo Clinic, Phoenix, Arizona, USA; Precision Neuro-therapeutics Innovation Lab, Mayo Clinic, Phoenix, Arizona, USA; Neurosurgery Simulation and Innovation Lab, Mayo Clinic, Phoenix, Arizona. Electronic address:

Fluorescence-guided resection of brain tumors using 5-aminolevulinic acid (5-ALA) has been established for high-grade gliomas. Recently, its application for the resection of low grade tumors and benign lesions including meningioma has been suggested in the literature. Achieving a Simpson grade I resection in meningioma surgery is associated with a lower rate of recurrence. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.178DOI Listing

Chondromyxoid fibroma of the temporal bone: A rare case report.

Medicine (Baltimore) 2020 Mar;99(11):e19487

Department of Otorhinolaryngology, Beijing Tongren Hospital.

Rationale: Chondromyxoid fibroma (CMF) is a rare form of benign bone tumor and easily misdiagnosed as fibrosarcoma. Hence, to explore the clinical manifestations, diagnostic tests, and therapeutic procedures for temporal bone cartilage myxoid fibroma, it is important to optimize patient treatment and avoid overtreatment. Previous research has discussed cases of CMF, but this paper presents a systematic, complete, and comprehensive introduction of this disease based on this case and related literature. Read More

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http://dx.doi.org/10.1097/MD.0000000000019487DOI Listing
March 2020
5.723 Impact Factor

A case report of squamous papilloma of the hard palate in a pediatric patient.

J Indian Soc Pedod Prev Dent 2020 Jan-Mar;38(1):91-93

Department of Pedodontics, Rajarajeswari Dental College and Hospital, Bengaluru, Karnataka, India.

Oral squamous papillomas are benign proliferating lesions induced by human papillomavirus. These lesions are painless and slowly-growing masses. As an oral lesion, it raises concern because of its clinical appearance. Read More

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http://dx.doi.org/10.4103/JISPPD.JISPPD_71_18DOI Listing

Birt-Hogg-Dubé syndrome with simultaneous hyperplastic polyposis of the gastrointestinal tract: case report and review of the literature.

BMC Med Genet 2020 03 14;21(1):52. Epub 2020 Mar 14.

Section of General Surgery and Gastrointestinal Surgery, Department of Surgery I, Faculdade de Medicina do ABC, Avenida Lauro Gomes, 2000, Santo André/São Paulo, CEP 09060-870, Brazil.

Background: Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant genodermatosis characterized by benign growth of the hair follicles, the presence of pulmonary cysts, spontaneous pneumothorax, and bilateral renal tumors that are usually hybrid oncocytic or multifocal chromophobe renal cell carcinoma. The diagnosis is confirmed by the presence of a pathogenic variant in the tumor suppressor folliculin (FLCN) gene mapped at 17p11.2. Read More

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http://dx.doi.org/10.1186/s12881-020-0991-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071710PMC

Glioma Migration Through the Corpus Callosum and the Brainstem Detected by Diffusion and Magnetic Resonance Imaging: Initial Findings.

Front Hum Neurosci 2019 25;13:472. Epub 2020 Feb 25.

Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

: Glioma cell infiltration, in which the glioma tumor cells spread long distances from the primary location using white matter (WM) or blood vessels, is known as a significant challenge for surgery or localized chemotherapy and radiation therapy. Following the World Health Organization (WHO), the glioma grading system ranges from stages I to IV, in which lower-grade gliomas represent benign tumors, and higher grade gliomas are considered the most malignant. : We gathered magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) data for seven patients with right precentral gyrus-located tumors and six age- and sex-matched healthy subjects for analysis. Read More

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http://dx.doi.org/10.3389/fnhum.2019.00472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052521PMC
February 2020
2.895 Impact Factor

Management of progressive facial asymmetry owing to a rare temporomandibular joint tumour: A case report.

J Orthod 2020 Jun 1;47(2):163-169. Epub 2020 Mar 1.

Frimley Health NHS Foundation Trust, Slough, UK.

Osteochondroma of the condyle is a rare, slow-growing, benign tumour of the temporomandibular joint that can result in facial asymmetry, limited mouth opening, temporomandibular joint dysfunction and malocclusion. The large majority of osteochondromas occur at the distal metaphysis of the femur and the proximal metaphysis of the tibia, whereas only 0.6% of osteochondromas have been reported as occurring in the craniofacial region. Read More

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http://dx.doi.org/10.1177/1465312520908272DOI Listing

Benign leiomyoma with multiple metastases to vertebrae and calvarium: An index case with comprehensive review of endocrine targets.

Neurosurg Rev 2020 Feb 20. Epub 2020 Feb 20.

Department of Radiology, Acibadem University, İstanbul, Turkey.

"Benign" metastatic leiomyomas (BML) are indolently growing metastatic tumors which mostly associate with uterine leiomyomas in women in reproductive ages. The reason to define these lesions as "benign" despite metastasis is their pathological features with low mitotic counts, lack of or minimal nuclear atypia, pseudocyst formation, and coagulative necrosis unlike leiomyosarcomas. Despite lack of pathological malignant features, they may cause significant morbidity and even mortality. Read More

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http://dx.doi.org/10.1007/s10143-020-01268-5DOI Listing
February 2020

[Application of endoscopic resection of benign tumor in infratemporal fossa].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;55(2):87-93

Department of Otorhinolaryngology Head and Neck Surgery, the Affiliated Hospital of Qingdao University, Otorhinolaryngology Head and Neck Surgery Key Laboratory of Shandong Province, Qingdao 266003, China; Department of Skull Base Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266003, China; Department of Allergy, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.

To explore the application of endoscopy and clinical effect of endoscopic resection of benign tumor in infratemporal fossa. The clinical data of 11 patients with benign tumors in infratemporal fossa admitted to the Department of Otorhinolaryngology Head and Neck Surgery and Skull Base Surgery of the Affiliated Hospital of Qingdao University from January 2016 to September 2018 were retrospectively analyzed. There were 6 males and 5 females, with the age ranging from 11 to 63 years old. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2020.02.002DOI Listing
February 2020

Metachronous Bilateral Vestibular Schwannomas.

Laryngoscope 2020 Feb 17. Epub 2020 Feb 17.

Sorbonne University, Paris, France.

Bilateral vestibular schwannoma (BVS) is the hallmark of neurofibromatosis type 2 (NF2), both of them being present at diagnosis. We report four cases of metachronous BVS, a contralateral intracanalicular vestibular schwannomas (VS) being visible 2 to 13 years after resection of a unilateral VS. NF2 workup was negative except in one case where two NF2 gene mutations were found in tumor analysis. Read More

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http://dx.doi.org/10.1002/lary.28571DOI Listing
February 2020
2.032 Impact Factor

Imaging of skull vault tumors in adults.

Insights Imaging 2020 Feb 13;11(1):23. Epub 2020 Feb 13.

Department of Neuroradiology, Hospital Universitari de Bellvitge, C. Feixa Llarga SN, 08907, L'Hospitalet de Llobregat, Spain.

The skull vault, formed by the flat bones of the skull, has a limited spectrum of disease that lies between the fields of neuro- and musculoskeletal radiology. Its unique abnormalities, as well as other ubiquitous ones, present particular features in this location. Moreover, some benign entities in this region may mimic malignancy if analyzed using classical bone-tumor criteria, and proper patient management requires being familiar with these presentations. Read More

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http://dx.doi.org/10.1186/s13244-019-0820-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018895PMC
February 2020

Benign temporomandibular joint tumours with extension to infratemporal fossa and skull base: condyle preserving approach.

Int J Oral Maxillofac Surg 2020 Feb 7. Epub 2020 Feb 7.

Department of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, and Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai, China. Electronic address:

This article introduces a modified surgical approach combining condylotomy with posterior disc attachment release for the resection of large non-malignant masses located in the infratemporal fossa and involving the skull base. This retrospective study included 14 patients treated at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University between January 2010 and December 2016. Clinical evaluations (visual analogue scale (VAS) for pain, maximum inter-incisal opening (MIO), and complications) and radiological findings (magnetic resonance imaging (MRI) and computed tomography (CT)) were collected pre- and postoperatively. Read More

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http://dx.doi.org/10.1016/j.ijom.2019.12.009DOI Listing
February 2020

Primordial odontogenic tumor: A systematic review.

Med Oral Patol Oral Cir Bucal 2020 May 1;25(3):e388-e394. Epub 2020 May 1.

Health Care Department Universidad Autónoma Metropolitana Calzada del Hueso 1100, Col Villa Quietud Delg. Coyaoacan, C.P.04960 Ciudad de México

Background: The primordial odontogenic tumor (POT) is a recently described benign entity with histopathological and immunohistochemical features suggesting its origin during early odontogenesis.

Aim: To integrate the available data published on POT into a comprehensive analysis to better define its clinicopathological and molecular features.

Material And Methods: An electronic systematic review was performed up to September 2019 in multiple databases. Read More

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http://dx.doi.org/10.4317/medoral.23432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211380PMC

[Treatment of petroclival meningiomas: current state of the problem].

Zh Vopr Neirokhir Im N N Burdenko 2019 ;83(6):78-89

Burdenko Neurosurgical Center, Moscow, Russia.

Petroclival meningiomas (PCMs) are benign, slowly growing tumors. Surgery still remains the main treatment option for them. The desire for total resection of large extended PCMs often leads to the development or worsening of persistent neurological deficits. Read More

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http://dx.doi.org/10.17116/neiro20198306178DOI Listing

Primary pigmented meningeal melanocytoma originating in Meckel cave in a patient with carney complex: A case report.

Medicine (Baltimore) 2020 Jan;99(3):e18783

Neurosurgery Department, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Saudi Arabia.

Rationale: Primary melanin-producing tumors are rare extra-axial neoplasms OPEN of the central nervous system. In the literature, few case reports have discussed neoplasms involving the cavernous sinus; of these, only 4 have reported on neoplasms originating in Meckel cave. The diagnostic approach, including clinical and radiological analysis, is challenging, and cytopathological assessment with a molecular basis is the best approach to discriminate between these lesions. Read More

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http://dx.doi.org/10.1097/MD.0000000000018783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220446PMC
January 2020

Clinical evaluation of the effectiveness of the developed method of conductive anesthesia of the facial branches of great auricular nerve

Wiad Lek 2019 Aug;72(8):1442-1446

Danylo Halytsky Lviv National Medical University, Lviv, Ukraine

Introduction: The most common method of local anesthesia of maxillofacial region in the modern surgical practice is conductive anesthesia of the peripheral branches of trigeminal nerve. In order to reach the total anesthesia of the lateral facial region it is necessary to block not only auriculo-temporal and buccal nerves, but also facial branches of great auricular nerve taking part in the innervation of parotid-masticatory area and the part of the cheek. Topographic-anatomical investigations of corpses revealed the anatomical variability of the branching of great auricular nerve on the neck and the head. Read More

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Intradiploic Epidermoid of the Tegmen Tympani With Cochlear Invasion.

Ear Nose Throat J 2020 Jan 22:145561319900754. Epub 2020 Jan 22.

Department of Otolaryngology-Head & Neck Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.

Intradiploic epidermoid cysts are benign tumors that account for ∼1% of all intracranial space occupying lesions. Because of the indolent growth, symptoms are usually gradual in onset with a prolonged duration. While they can originate from any part of the skull, temporal bone epidermoids are rare. Read More

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http://dx.doi.org/10.1177/0145561319900754DOI Listing
January 2020

Soft Tissue Special Issue: Chondroid Neoplasms of the Skull.

Head Neck Pathol 2020 Mar 16;14(1):83-96. Epub 2020 Jan 16.

Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, The Ottawa Hospital/University of Ottawa, 501 Smyth Rd, 4th Floor CCW, Room 4250, Ottawa, ON, K1H 8L6, Canada.

Clinically, radiologically, and pathologically, chondroid neoplasms of the skull can be diagnostically challenging due to overlapping features in each of these domains. Compounding the problem for the pathologist, there is also significant morphologic, immunophenotypic, and molecular genetic overlap between benign and malignant cartilaginous lesions, and the majority of these lesions are encountered quite rarely in routine surgical pathology practice. Each of these factors contribute to the diagnostic difficulty posed by these lesions, highlighting the importance of radiologic-pathologic correlation in the diagnosis. Read More

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http://dx.doi.org/10.1007/s12105-019-01091-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021846PMC

Adenoid ameloblastoma in the posterior maxilla: a case report and review of the literature.

Oral Maxillofac Surg 2020 Jun 11;24(2):243-249. Epub 2020 Jan 11.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Introduction: Adenoid ameloblastoma is a rare benign odontogenic tumor that favors a slight predilection for male patients, fourth and fifth decades of life, and posterior regions of the jaws. To date, less than 40 cases have been reported in the English language literature. The radiographic aspects of adenoid ameloblastoma vary from unilocular and well-defined lesions to diffuse and multilocular lesions. Read More

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http://dx.doi.org/10.1007/s10006-020-00830-1DOI Listing

A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman.

Case Rep Pulmonol 2019 24;2019:6458302. Epub 2019 Nov 24.

AM Rywlin Department of Pathology and Laboratory Medicine, Mount Sinai Medical Centre, Miami Beach, FL, USA.

Primary benign neurogenic neoplasms of the pleura are exceedingly rare. Neurofibromas rarely involve the pleura. A review of the literarture reveals only a single reported case of isolated pleural neurofibroma. Read More

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http://dx.doi.org/10.1155/2019/6458302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906869PMC
November 2019

From Juvenile Nasopharyngeal Angiofibroma to Nasopharyngeal Carcinoma; A Rare Case Report of Nasopharyngeal Mass.

Bull Emerg Trauma 2019 Oct;7(4):424-426

Department of Rhinology and Skull Base Surgery, ENT and Head and Neck Research Center, Hazrat Rasoul Hospital, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran.

Nasopharyngeal masses in young males, first of all presumes Juvenile Nasopharyngeal Angiofibroma (JNA) in the mind, but other benign or malignant tumors should be considered for successful and adequate management of patients and also for minimizing morbidity from unnecessary interventions. We herein present a patient with nasopharyngeal carcinoma (NPC) mimicking JNA. The patient was presumed as JNA and underwent excessive surgical intervention and the final histopathology report was NPC. Read More

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http://dx.doi.org/10.29252/beat-070414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911716PMC
October 2019

Multidisciplinary approaches to odontogenic lesions.

Curr Opin Otolaryngol Head Neck Surg 2020 Feb;28(1):36-45

Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Purpose Of Review: To give an overview of technical considerations and relevant literature in the management odontogenic pathology with involvement of the maxillary sinus.

Recent Findings: Infections, cysts, benign neoplasms (odontogenic and nonodontogenic), and inflammatory conditions impact the maxillary sinus in various ways, could result in significant expansion within the maxillary sinus and significant infections.

Summary: This manuscript provides an overview of common pathologic entities of the oral cavity proper that impacts the maxillary sinus health, with discussion of the role of the otorhinolaryngologist and the dental specialist. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000603DOI Listing
February 2020

The limits of endoscopic endonasal approaches in young children: a review.

Childs Nerv Syst 2020 02 16;36(2):263-271. Epub 2019 Dec 16.

Leo Davidoff Department of Neurological Surgery, Division of Pediatric Neurosurgery, Children's Hospital at Montefiore, Albert Einstein College of Medicine, 3415 Bainbridge Ave, The Bronx, NY, 10467, USA.

Introduction: The endoscopic endonasal approach (EEA) provides visualization of four deep surgical corridors (transcribiform, transtubercular, transsellar, and transclival) with superior illumination and specialized deep-reaching instruments, as compared to microscopic techniques. Several studies have evaluated EEAs in children but do not stratify for the very young of age, whose particularly small nares and developmental anatomy may limit endonasal instrumentation.

Methodology: A comprehensive review of EEAs in infants and children to age 4 was performed to determine the limitations in this age group. Read More

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http://dx.doi.org/10.1007/s00381-019-04455-yDOI Listing
February 2020

When a Meningioma Isn't: Endoscopic Endonasal Orbital Decompression and Biopsy of Skull Base Rosai-Dorfman Disease Treated Previously with Empiric Radiation Therapy.

World Neurosurg 2020 Mar 13;135:141-145. Epub 2019 Dec 13.

Department of Neurological Surgery, The Ohio State University Wexner Medical Center, The James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA. Electronic address:

Background: Rosai-Dorfman disease (RDD) is a rare, benign histiocytosis disorder with only approximately 100 reported central nervous system cases in the literature. Even less common is skull base involvement of RDD, with about 41 reported cases. Radiographically, RDD can appear similar to a meningioma; the true diagnosis is only found with histologic analysis. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.12.032DOI Listing

Molecular findings in maxillofacial bone tumours and its diagnostic value.

Virchows Arch 2020 Jan 14;476(1):159-174. Epub 2019 Dec 14.

Bone Tumour Reference Centre, Institute of Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.

According to the WHO, mesenchymal tumours of the maxillofacial bones are subdivided in benign and malignant maxillofacial bone and cartilage tumours, fibro-osseous and osteochondromatous lesions as well as giant cell lesions and bone cysts. The histology always needs to be evaluated considering also the clinical and radiological context which remains an important cornerstone in the classification of these lesions. Nevertheless, the diagnosis of maxillofacial bone tumours is often challenging for radiologists as well as pathologists, while an accurate diagnosis is essential for adequate clinical decision-making. Read More

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http://dx.doi.org/10.1007/s00428-019-02726-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968989PMC
January 2020

Desmoplastic ameloblastoma: a systematic review of the cases reported in the literature.

Int J Oral Maxillofac Surg 2020 Jun 4;49(6):709-716. Epub 2019 Dec 4.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:

The aim of this study was to integrate the available data published on desmoplastic ameloblastoma (DA) into a comprehensive analysis of its clinical/radiographic features. As it is not clear whether the hybrid ameloblastoma has a unique biological behaviour, the clinical/radiographic features of conventional DA were compared with those of the hybrid variant. An electronic search was undertaken in May 2019. Read More

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http://dx.doi.org/10.1016/j.ijom.2019.11.004DOI Listing

Phyllodes tumor with metastases to the skull managed with local excision: A case report.

Rare Tumors 2019 26;11:2036361319890710. Epub 2019 Nov 26.

Medical Oncology, Norris Comprehensive Cancer Center, Los Angeles, CA, USA.

The behavior of phyllodes tumors is unpredictable and can behave as benign fibroadenomas or malignant neoplasms mimicking the course of aggressive sarcomas, characterized by distant metastases and a high short-term mortality. The malignant forms are treated with surgery and adjuvant chemotherapy, but often with poor outcomes. We examine the first reported case of an aggressive osteosarcoma subtype of phyllodes tumor that recurred in the skull after total mastectomy and adjuvant chemotherapy. Read More

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http://dx.doi.org/10.1177/2036361319890710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880032PMC
November 2019

Edema Surrounding Benign Tumors and Tumor-Like Lesions.

Biomed Res Int 2019 29;2019:8206913. Epub 2019 Oct 29.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.

Objective: To explore the incidence and significance of intra- and extra-osseous edema associated with benign tumors and tumor-like diseases.

Methods: Magnetic resonance imaging (MRI) data from 300 benign osseous tumors and tumor-like diseases diagnosed by pathology were retrospectively reviewed. Borderline tumors, cases associated with pathological fractures, and skull lesions were excluded from the study. Read More

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http://dx.doi.org/10.1155/2019/8206913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874953PMC

[Update on intrasellar arachnoid cyst: a case study].

Pan Afr Med J 2019 27;34:55. Epub 2019 Sep 27.

Service de Neurochirurgie, Centre Hospitalier National Universitaire de Fann, Université Cheikh Anta Diop, Dakar, Sénégal.

Intrasellar arachnoid cysts are benign malformations. They are extremely rare (approximately 3% of cases). Their pathophysiology is still poorly elucidated. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.55.18564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859025PMC
December 2019

Proliferative fasciitis of the chin: A report of the rare case and review of literature.

Indian J Dent Res 2019 Jul-Aug;30(4):630-633

Department of Oral Pathology and Microbiology, Government Dental College, Kozhikode, Kerala, India.

Proliferative fasciitis is a pseudo-sarcomatous myofibroblastic proliferation characterized by the presence of unusual giant cells resembling ganglion cells, which usually occurs in the adult population with a mean age of 54 years. It usually affects the upper extremities and is rare in head and neck region with only 11 cases described in the literature so far. Because of rapid growth and histological similarity to various malignant tumors such as rhabdomyosarcoma, recognition of this benign condition is a matter of utmost importance when a pathologist is concerned. Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_8_18DOI Listing
November 2019

A Sizeable Solitary Pedunculated Peripheral Osteoma of the Hard Palate: A Case Report.

Indian J Otolaryngol Head Neck Surg 2019 Oct 1;71(Suppl 1):813-815. Epub 2019 Jan 1.

1Sir Ivan Stedeford Hospital, Ambattur, Chennai, India.

Osteomas are benign, slow growing, usually sessile osteogenic tumors of unknown etiology. They arise from proliferation of either cancellous or compact bone. They can be central, peripheral or extra-skeletal based on their origin from endosteum, periosteum or extra-skeletal soft tissue respectively. Read More

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http://dx.doi.org/10.1007/s12070-018-1561-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848437PMC
October 2019

[Diagnosis and treatment of glomus tumors of the skull base and neck].

Radiologe 2019 Dec;59(12):1051-1057

Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinik des Saarlandes, Kirrberger Straße, 66424, Homburg-Saar, Deutschland.

Glomus tumors (paragangliomas) are rare, usually benign, neuroendocrine tumors that arise from nonchromaffin cells and can be multifocal or familial. They grow slowly, often infiltratively and rarely form metastases. A distinction is made between carotid, jugular, tympanicum and vagal tumors. Read More

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http://dx.doi.org/10.1007/s00117-019-00605-0DOI Listing
December 2019

Surgical Management of a Recurrent Odontogenic Keratocyst With Orbital and Temporal Fossa Invasion.

Ophthalmic Plast Reconstr Surg 2019 Nov/Dec;35(6):e151-e154

Orbital and Ophthalmic Plastic Surgery, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Wauwatosa, Wisconsin, U.S.A.

Odontogenic keratocyst is a benign locally aggressive odontogenic cyst with a high recurrence rate. This report presents an unusual case of a recurrent odontogenic keratocyst with zygomatic bone involvement and orbital and temporal extension resulting in globe compression. Odontogenic keratocyst is reviewed, and surgical management of the cyst is discussed. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001477DOI Listing
January 2020
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Odontogenic keratocyst of the mandible: A case report and literature review.

Dent Med Probl 2019 Oct-Dec;56(4):433-436

Division of Dental Surgery, Department of Craniomaxillofacial Surgery and Oral Surgery, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Bytom, Poland.

Based on a literature review, we analyzed the World Health Organization (WHO) classification and the treatment algorithm for the odontogenic keratocyst (OKC), formerly referred to as keratocystic odontogenic tumor (KCOT). The KCOT reclassification from benign odontogenic tumors to odontogenic developmental cysts resulted from the emergence of new evidence regarding their morphogenesis and biological behavior. The authors of the most recent 2017 classification do not provide specific guidelines for OKC. Read More

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http://dx.doi.org/10.17219/dmp/110682DOI Listing
January 2020

Racial Differences in Hospital Stays among Patients Undergoing Craniotomy for Tumour Resection at a Single Academic Hospital.

Brain Tumor Res Treat 2019 Oct;7(2):122-131

Department of Neurosurgery, Ronald Reagan UCLA Medical Center of the David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA.

Background: Racial differences in American patients undergoing brain tumour surgery remain poorly characterized within urban medical centres. Our objective was to assess racial differences in operative brain tumour patients at a single academic hospital in Los Angeles, California.

Methods: We reviewed medical records of adult patients undergoing craniotomy for tumour resection from March 2013 to January 2017 at UCLA Medical Centre. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829091PMC
October 2019
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Denosumab Therapy Obscures Histological Features of Giant Cell Tumor of Bone.

J Neuropathol Exp Neurol 2019 12;78(12):1171-1173

Departments of Pathology, Neurology and Neurosurgery, University of Colorado, Aurora, Colorado.

Giant cell tumor (GCT) of bone is a locally aggressive tumor with low metastatic potential, usually originating in long bones. Numerous spinal examples have been reported and thus GCTs can be encountered by neuropathologists. We describe a 69-year-old man with more than a 10-year history of GCT primary to the femur that had recently metastasized to the occipital skull bone. Read More

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http://dx.doi.org/10.1093/jnen/nlz100DOI Listing
December 2019
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Image-Guided Percutaneous Management of Skull and Spine Giant Cell Tumors: Case Report of 2 Challenging Cases Successfully Treated with Doxycycline Sclerotherapy.

World Neurosurg X 2020 Jan 25;5:100061. Epub 2019 Sep 25.

Department of Radiology, Nationwide Children's Hospital, Columbus, Ohio, USA.

Background: A giant cell tumor (GCT) of bone is a benign, locally aggressive tumor that is often challenging to treat. When complete resection is not possible, curettage with or without adjuvants is the most common treatment. The high frequency of local recurrence and risk of injury to adjacent structures can limit this surgical approach, especially with skull and spine lesions. Read More

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http://dx.doi.org/10.1016/j.wnsx.2019.100061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807377PMC
January 2020