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J Pharm Biomed Anal 2021 May 5;201:114119. Epub 2021 May 5.

Institute of TCM International Standardization, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Lycium fruits have a high content of phenolics as bioactive constituents with various pharmacological effects, but there is a lack of comparative analysis and chemical profiling of phenolics in Lycium fruit varieties. An ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) combined with chemometrics was developed to characterize the phenolics in fruits from four Lycium species, including Lycium barbarum L. (LBL), L. Read More

Eur J Obstet Gynecol Reprod Biol 2021 May 5;262:28-35. Epub 2021 May 5.

Nuova Villa Claudia, Radiology Department, Via Flaminia Nuova 280, 00191, Rome, Italy; Polizia di Stato, Centro Clinico di Medicina Preventiva e Medicina Legale, Via Mamiani 2, Roma, Italy.

Pregnancy related transient osteoporosis of the hip (PR-TOH) is a rare condition that manifests with sudden pain located in the groin region, anterior thigh and buttocks. It is a benign and in the majority of cases self-limiting disease, related to bone marrow oedema. It occurs during the third trimester of pregnancy or less frequently during the post-partum period. Read More

Eur J Obstet Gynecol Reprod Biol 2021 May 5;262:21-27. Epub 2021 May 5.

Division of Gynecologic Oncology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: The aim of this study was to describe one of the largest series of disseminated peritoneal leiomyomatosis (DPL) and its malignant counterpart, evaluating possible risk factors for both the benign and malignant condition, and highlighting any differences between them in terms of surgical and clinical management.

Study Design: Clinical, surgical and histopathological characteristics of patients diagnosed with DPL (group 1) and malignant-DPL (group 2), between July 2010 and July 2020, were retrospectively retrieved.

Results: A total of 14 benign and 5 malignant cases were selected. Read More

J Pediatr Adolesc Gynecol 2021 May 11. Epub 2021 May 11.

Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH. Electronic address:

Study Objective: Assess postoperative management of pediatric patients with benign ovarian neoplasms to develop recommendations for postoperative care.

Design: A retrospective cohort study.

Setting: Eight pediatric hospitals in the Midwest. Read More

Neurochirurgie 2021 May 11. Epub 2021 May 11.

Head of Department, Neurosurgery University Hospital Reims, URCA (Université de Reims Champagne-Ardennes), Reims, France.

Meningiomas are the most common tumors of the central nervous system. Most meningiomas are benign and occur mainly in middle aged women. Only a few cases of meningiomas in identical twins have been reported. Read More

Am J Dermatopathol 2021 May 11. Epub 2021 May 11.

Virginia Tech Carilion School of Medicine, Roanoke, VA; Dermatology Section, Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Roanoke, VA; Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA; and Oculofacial Plastic and Reconstructive Surgery, Vistar Eye Center, Roanoke, VA.

Abstract: Oncocytomas are benign neoplasms that are most often found in the salivary glands and kidneys. Ocular oncocytoma typically present as an asymptomatic dark blue papule on the lacrimal caruncle. Histologically, the tumor is composed of oncocytes, cells notable for eosinophilic cytoplasmic granules representing large quantities of dysfunctional mitochondria. Read More

Am J Dermatopathol 2021 May 11. Epub 2021 May 11.

Wright State University Boonshoft School of Medicine, Dayton, OH; and Departments of Dermatology and Pathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA.

Abstract: A neurofibroma is a benign neural tumor arising within a peripheral nerve sheath composed of Schwann cells, fibroblasts, and immune cells involved in the nerve. Microcystic elements have been rarely described in these tumors. Neurofibromas are classically described as unencapsulated tumors of interspersed spindle cells and mast cells in a hypocellular, myxoid stroma. Read More

Am J Dermatopathol 2021 May 11. Epub 2021 May 11.

Departments of Dermatology, and Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; and AU/UGA Medical Partnership, Medical College of Georgia, Athens, GA.

Abstract: In their 2018 article, Lezcano et al [AJSP 2018(11):1456] show that diffuse tumor cell nuclear reactivity for Preferentially expressed Antigen in Melanoma (PRAME) is a feature of melanoma and that benign and atypical melanocytic tumors are PRAME negative or show only focal positivity for PRAME. We report our observations of PRAME staining in 253 melanocytic tumors. Tumors were classified by hematoxylin and eosin sections. Read More

Radiographics 2021 May 14:200161. Epub 2021 May 14.

From the Departments of Radiology (R.A.K., G.K.N., E.P.C., J.H.S., J.L.J., M.N., E.V.M.) and Pathology (A.A.), MedStar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC 20007; and Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY (V.L.M.).

Patients who have undergone mastectomy, with or without reconstruction, are not universally screened with mammography or US. Therefore, clinical breast examination by the physician and patient-detected palpable abnormalities are crucial for detecting breast cancer or recurrence. Diagnostic US is the first-line modality for evaluation of postmastectomy palpable masses, with occasional adjunct use of diagnostic mammography for confirming certain benign masses. Read More

Br J Radiol 2021 May 14:20201444. Epub 2021 May 14.

Department of Radiology, Glasgow Royal Infirmary, NHS GG&C, Glasgow, UK.

Objectives: To compare diagnostic performance of British Thyroid Association (BTA), American College of Radiology Thyroid Imaging Reporting and Data System (ACR-TIRADS) and Artificial Intelligence TIRADS (AI-TIRADS) for thyroid nodule malignancy. To determine comparative unnecessary FNA rates.

Methods: 218 thyroid nodules with definitive histology obtained during 2017 were included. Read More

Org Lett 2021 May 14. Epub 2021 May 14.

School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P.R. China.

We designed a cooperative catalytic system by combining commercially available Ca(NTf)PF and Pd(PPh) to address the dehydrative allylation of alkenyl sp C-H bonds in an environmentally benign manner. A novel C-OH bond cleavage method was found to be crucial for this practical protocol. A variety of alkenes and allylic alcohols equipped with wide-spectrum functional groups can be successfully incorporated into the desired cross-coupling, affording 1,4-dienes with moderate to excellent yields and high stereo- and regioselectivity. Read More

Minerva Obstet Gynecol 2021 May 14. Epub 2021 May 14.

Department of Obstetrics and Gynecology, University of Bari, Bari, Italy.

Introduction: Uterine fibroids (UFs) are the most common benign disease affecting female reproductive system, occur in 20-40 % of women, and in 10 % of pregnancies. The aim of the investigation was to summarize evidences about the management and treatment of UFs and related complications in pregnancy.

Materials And Methods: A literature review was performed using scientific databases, including all case report and case series, using a combination of key words relating to the problem exposed. Read More

Minerva Med 2021 May 14. Epub 2021 May 14.

Cardiology Unit, Town Hospital of Cittadella, Cittadella, Padova, Italy -

Isolated systolic hypertension in the youth, is still a challenging problem. The prevalence of this hypertensive subtype may vary according to the different population study and is peculiar of male subjects among the youngest age classes. Several are the mechanisms reported as possible underlying causes of isolated systolic blood pressure elevation and again these differ according to the different study cohort and may vary from overweight and obesity status, linked to sympathetic overactivity, to increased and earlier arterial stiffness, hyperkinetic state, or exaggerated pulse pressure amplification form central to peripheral sites, due to enhanced arterial elasticity. Read More

Cardiovasc Intervent Radiol 2021 May 13. Epub 2021 May 13.

Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Purpose: Although hydatid liver cyst (HLC) is a benign disease, treatment is recommended to avoid life-threatening complications. There are several treatment options for HLC: "wait-and-watch," medical or surgical or percutaneous treatment. The purpose of this study was to assess the long-term effectiveness of an alternative of the traditional percutaneous PAIR procedure, called double percutaneous aspiration and ethanol injection (D-PAI). Read More

J Health Econ Outcomes Res 2021 May 6;8(1):42-50. Epub 2021 May 6.

Carolina Urologic Research Center, Myrtle Beach, SC, USA.

Benign prostatic hyperplasia (BPH) is one of the most prevalent and costly chronic conditions among middle-aged and elderly men. Prostatic urethral lift (PUL) and convective water vapor thermal therapy (WVTT) are emerging minimally invasive surgical treatments as an alternative to traditional treatment options for men with moderate-to-severe BPH. This study evaluated the cost-effectiveness and budget impact of PUL and WVTT for men with BPH using long-term clinical outcomes. Read More

Ann Transl Med 2021 Apr;9(8):727

Fondazione Italiana Fegato, ONLUS Area Science Park Basovizza, Trieste, Italy.

NAFLD is an emerging healthcare epidemic that is causing predictable adverse consequences for healthcare systems, societies and individuals. Whilst NAFLD is recognized as a multi-system disease with compound pathways that are both benign and pernicious in their unfolding; NASH is generally understood as a deleterious follow-on condition with path-specific tendencies that progress to cirrhosis, HCC and liver transplantation. Recent evidence is beginning to challenge this interpretation demanding more attention to the personalized nature of the disease and its pathogenesis across multiple different cohorts. Read More

Ann Transl Med 2021 Apr;9(8):723

Department of Thoracic Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China.

Synchronous multiple nodules in the lungs, such as peripheral ground-glass opacities (GGOs) and solid small nodules, are common, but only lesions suspected of being malignant should be surgically removed. The surgical strategy is anatomical sub-lobectomy in early stage of non-small cell lung cancer synchronously or asynchronously to decrease the impact of lung resection on the lung function. Here, we report a case of a 56-year-old man, who was a pack-a-day smoker, with endobronchial hamartomas the medial basal bronchus (B7). Read More

Front Pediatr 2021 27;9:528966. Epub 2021 Apr 27.

Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

Endotracheal hamartomas are rarely encountered in children. The symptoms of endotracheal hamartoma may include cough, dyspnea, hemoptysis, chest pain, purulent sputum, and fever. The non-specific symptoms often result in a delayed diagnosis. Read More

Eur J Case Rep Intern Med 2021 12;8(4):002422. Epub 2021 Apr 12.

Department of Internal Medicine, Hospital Santa Maria Maior, Braga, Portugal.

The aetiology of pulmonary nodules is varied, with malignant lesions being the most important and requiring rapid diagnosis and treatment. However, although clinical presentation and imaging may suggest a specific diagnosis, it should be kept in mind that some benign pathologies mimic more serious disease. A 50-year-old man presented with left pleuritic chest pain. Read More

Front Oncol 2021 27;11:656918. Epub 2021 Apr 27.

Radiology and Diagnostic Imaging Department, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Background: The differentiation between benign and malignant parotid lesions is crucial to defining the treatment plan, which highly depends on the tumor histology. We aimed to evaluate the role of MRI-based radiomics using both T2-weighted (T2-w) images and Apparent Diffusion Coefficient (ADC) maps in the differentiation of parotid lesions, in order to develop predictive models with an external validation cohort.

Materials And Methods: A sample of 69 untreated parotid lesions was evaluated retrospectively, including 37 benign (of which 13 were Warthin's tumors) and 32 malignant tumors. Read More

Front Oncol 2021 27;11:575166. Epub 2021 Apr 27.

Department of General Internal Medicine, Kliniken Hirslanden Beau-Site, Bern, Switzerland.

Objective: The purpose of this study was to improve the differentiation between malignant and benign thyroid nodules using deep learning (DL) in category 4 and 5 based on the Thyroid Imaging Reporting and Data System (TI-RADS, TR) from the American College of Radiology (ACR).

Design And Methods: From June 2, 2017 to April 23, 2019, 2082 thyroid ultrasound images from 1396 consecutive patients with confirmed pathology were retrospectively collected, of which 1289 nodules were category 4 (TR4) and 793 nodules were category 5 (TR5). Ninety percent of the B-mode ultrasound images were applied for training and validation, and the residual 10% and an independent external dataset for testing purpose by three different deep learning algorithms. Read More

Cureus 2021 Apr 10;13(4):e14398. Epub 2021 Apr 10.

Medical Education, Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Davie, USA.

Melasma is a benign yet psychologically debilitating skin condition that is prevalent among women of darker phenotypes, and particularly in Asian women. This potentially preventable condition can lead to skin discoloration that is hard to treat and can frequently recur. This review aims to (1) highlight the pathophysiology of melasma, (2) describe its important risk factors, and (3) identify prevention methods, available treatment options, and potential complications of melasma. Read More

Onco Targets Ther 2021 6;14:3003-3011. Epub 2021 May 6.

Department of Pathology, Shihezi University School of Medicine and the First Affiliated Hospital to Shihezi University School of Medicine, Shihezi, Xinjiang, 832002, People's Republic of China.

Phyllodes tumors (PTs) account for less than 1% of breast tumors, and malignant PTs account for even less. Here, we described an unusual case of malignant PT with mixed liposarcoma (myxoid liposarcoma [MLP] and pleomorphic liposarcoma [PLP]). A 52-year-old woman discovered a small lump in her left breast. Read More

Proc SPIE Int Soc Opt Eng 2021 Feb 15;11598. Epub 2021 Feb 15.

Dept. of Robotics Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.

Office-based endoscopic laser surgery is an increasingly popular option for the treatment of many benign and pre-malignant tumors of the vocal folds. While these procedures have been shown to be generally safe and effective, recent clinical studies have revealed that there are a number of challenging locations inside the larynx where laser light cannot be easily delivered due to line-of-sight limitations. In this paper, we explore whether these challenges can be overcome through the use of side-firing laser fibers. Read More

Sci Rep 2021 May 13;11(1):10204. Epub 2021 May 13.

Urology Research Laboratory, Department for BioMedical Research DBMR, University of Bern, Bern, Switzerland.

Urgency, frequency and incomplete emptying are the troublesome symptoms often shared between benign prostatic obstruction-induced (BLUTD) and neurogenic (NLUTD) lower urinary tract dysfunction. Previously, using bladder biopsies, we suggested a panel of miRNA biomarkers for different functional phenotypes of the bladder. Urine is a good source of circulating miRNAs, but sex- and age-matched controls are important for urinary metabolite comparison. Read More

BMJ Case Rep 2021 May 13;14(5). Epub 2021 May 13.

Otorhinolaryngology and Head and Neck Surgery, Klinikum Mutterhaus der Borromäerinnen gGmbH, Trier, Deutschland, Germany.

Ameloblastoma (AM) in the maxillary sinus is rare. This benign entity shows locally invasive, destructive and aggressive behaviour and a high rate of recurrence. Therefore, the course of treatment is radical resection. Read More

AJNR Am J Neuroradiol 2021 May 13. Epub 2021 May 13.

From the Department of Radiology (G.R.K., J.H.Y., V.Y.P., J.Y.K.), Severance Hospital, Research Institute of Radiological Science, Center for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Korea

Background And Purpose: Comparison of the diagnostic performance for thyroid cancer on ultrasound between a convolutional neural network and visual assessment by radiologists has been inconsistent. Thus, we aimed to evaluate the diagnostic performance of the convolutional neural network compared with the American College of Radiology Thyroid Imaging Reporting and Data System (TI-RADS) for the diagnosis of thyroid cancer using ultrasound images.

Materials And Methods: From March 2019 to September 2019, seven hundred sixty thyroid nodules (≥10 mm) in 757 patients were diagnosed as benign or malignant through fine-needle aspiration, core needle biopsy, or an operation. Read More

Eur Urol Focus 2021 May 10. Epub 2021 May 10.

Department of Urology, Martha-Maria Hospital Nuremberg, Nuremberg, Germany. Electronic address:

Context: Low-intensity shockwave therapy (LiST) has emerged as an effective treatment for pain in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and it has been postulated that LiST may also be effective in patients with lower urinary tract symptoms (LUTS).

Objective: To perform a systematic review and meta-analysis of experimental and clinical studies exploring the effect of LiST on LUTS in an attempt to provide clinical implications for future research.

Evidence Acquisition: We systematically searched PubMed, Cochrane Library, and Scopus databases from inception to March 2021 for relevant studies. Read More

Nephrol Ther 2021 May 10. Epub 2021 May 10.

Centre de référence des Maladies rénales rares, service de néphrologie, rhumatologie et dermatologie pédiatriques, Hôpital Femme-Mère-Enfant, Hospices civils de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France. Electronic address:

Cat scratch disease, usually a benign infectious disease, may develop as multisystem disease with multiorgan involvement, particularly in immunocompromised patients. We report on a patient who developed disseminated bartonellosis while receiving mycophenolate mofetil monotherapy treating steroid-dependent nephrotic syndrome, highlighting that severe infection can be observed in those patients. Therefore, this category of patients should be cautious when having contact with kittens and receives proper prevention advice. Read More

HPB (Oxford) 2021 Apr 28. Epub 2021 Apr 28.

University of Groningen, University Medical Center Groningen, Department of Surgery, the Netherlands. Electronic address:

Background: Hepatocellular adenomas (HCA) are benign liver tumors at risk of hemorrhage. The influence of pregnancy on HCA growth and potential bleeding remains unclear. This study investigates HCA-associated behavior and bleeding complications during or shortly after pregnancy. Read More