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BMC Res Notes 2022 Jun 25;15(1):219. Epub 2022 Jun 25.

Department of Pathology, University of Iowa, Iowa City, IA, USA.

Objective: Inflammation is present in many diseases and identification of immune cell infiltration is a common assessment. CD138 (syndecan-1) is a recommended immunohistochemical marker for human plasmacytes although it is also expressed in various epithelia and tumors. Similarly, CD138 is a marker for murine plasmacytes, but its tissue immunostaining is not well-defined. Read More

PLoS One 2022 24;17(6):e0270608. Epub 2022 Jun 24.

Department of General Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Objective: To analyze the effects of primary tumor resection and metastatic lesion resection on the survival of metastatic small intestinal tumors.

Methods: The research subjects were patients with metastatic small bowel tumors identified from 2004 to 2016 in the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching and Kaplan-Meier analyses were performed to analyze the effect of surgery on the prognosis. Read More

In Vivo 2022 Jul-Aug;36(4):1603-1607

AntiCancer Inc, San Diego, CA, U.S.A.;

Background: Cancer of the Meckel's diverticulum (MD) is extremely rare. It is often advanced at the time of operation and the prognosis is poor. An effective treatment for this cancer has not yet been developed and there is no MD-carcinoma mouse model. Read More

Arq Bras Cir Dig 2022 17;35:e1658. Epub 2022 Jun 17.

Department of General Surgery, Hospital Nossa Senhora da Conceição (HNSC) - Porto Alegre - RS - Brazil.

Aim: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the digestive tract and has a wide variation in biological behavior; surgical resection remains the main form of treatment. This study aimed to analyze clinicopathological characteristics and survival of patients with GIST in a reference institution for oncological diseases.

Methods: An observational, longitudinal, and retrospective study of patients diagnosed with GIST from January 2011 to January 2020 was carried out by analyzing epidemiological and clinical variables, staging, surgical resection, recurrence, use of imatinib, and curves of overall survival (OS) and disease-free survival (DFS). Read More

Langenbecks Arch Surg 2022 Jun 22. Epub 2022 Jun 22.

Hiram C. Polk, Jr MD Department of Surgery, Price Institute of Surgical Research, University of Louisville, Louisville, KY, 40292, USA.

Despite advances in medical therapy, surgery continues to play a vital role in the management of Crohn's disease and its complications. Continuing from Part I of this series (small intestine/ileal disease), we focus next on colonic Crohn's disease and associated neoplasms. We will first review the surgical management of medical-refractory Crohn's colitis and its complications and then examine cancer risk, surveillance, and surgical management of Crohn's-associated colorectal dysplasia and malignancy. Read More

World J Gastrointest Endosc 2022 May;14(5):267-290

Division of Gastroenterology Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.

Gastroenteropancreatic neuroendocrine neoplasms are a heterogenous group of rare neoplasms that are increasingly being discovered, often incidentally, throughout the gastrointestinal tract with varying degrees of activity and malignant potential. Confusing nomenclature has added to the complexity of managing these lesions. The term carcinoid tumor and embryonic classification have been replaced with gastroenteropancreatic neuroendocrine neoplasm, which includes gastrointestinal neuroendocrine and pancreatic neuroendocrine neoplasms. Read More

Intern Med J 2022 Jun;52(6):1093-1094

Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

BMC Urol 2022 Jun 17;22(1):87. Epub 2022 Jun 17.

Department of Urology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, 365000, Fujian, China.

Background: Ileal neobladder fistula is a rare complication after radical cystectomy, with an incidence of approximately 0.7%. At present, there are scattered reports of vesicoileal fistula, but there are no reports of ileal neobladder fistula (INF) caused by bladder stones. Read More

J Transl Med 2022 Jun 15;20(1):272. Epub 2022 Jun 15.

Department of Pancreatobiliary Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, China.

Background: Ampullary adenocarcinoma (AAC) arises from the ampulla of Vater where the pancreatic duct and bile duct join and empty into the duodenum. It can be classified into intestinal and pancreatobiliary types based on histopathology or immunohistochemistry. However, there are no biomarkers for further classification of pancreatobiliary-type AAC which has important implications for its treatment. Read More

Zentralbl Chir 2022 Jun 15;147(3):270-280. Epub 2022 Jun 15.

Chirurgische Klinik Campus Charité Mitte | Campus Virchow-Klinikum, Charité Universitätsmedizin Berlin, Berlin, Deutschland.

Neuroendocrine neoplasias comprise a heterogenous group of malignant tumours, mostly arising from the gastro-entero-pancreatic system (GEP). Most of these tumours develop from the small intestine and pancreas and the liver is the predominant site for distant metastases. Patients may be asymptomatic for a long time and liver metastases are frequently diagnosed by chance or during operations for bowel obstruction, for example, during emergency surgery. Read More

Cancer Imaging 2022 Jun 14;22(1):27. Epub 2022 Jun 14.

Department of Radiology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Background: Melanoma is the most aggressive form of skin cancer, with a tendency to metastasise to any organ of the human body. While the most common body organs affected include liver, lungs, brain and soft tissues, spread to the gastrointestinal tract is not uncommon. In the bowel, it can present with a multitude of imaging appearances, more rarely as an aneurysmal dilatation. Read More

Gastrointest Endosc Clin N Am 2022 Jul 11;32(3):545-562. Epub 2022 May 11.

Department of Gastroenterology & Hepatology, Erasmus University Medical Center, Dr. Molewaterplein 40, Rotterdam 3015 GD, the Netherlands. Electronic address:

Most ampullary lesions (ALs) are sporadic, involve the major papilla, and are premalignant (adenomas). They are often diagnosed as an incidental finding during endoscopy or imaging procedures. Diagnosis and staging of ALs include endoscopic, histologic, and radiological evaluations. Read More

ANZ J Surg 2022 06;92(6):1577

Department of Colorectal Surgery, Garg Fistula Research Institute, Panchkula, India.

World J Gastrointest Surg 2022 Apr;14(4):276-285

Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw 02-097, Poland.

Neuroendocrine neoplasms (NENs) of the gastroenteropancreatic system are rare and heterogeneous tumours, yet with increasing prevalence. The most frequent primary sites are the small intestine, rectum, pancreas, and stomach. For a localized disease, surgical resection with local lymph nodes is usually curative with good overall and disease free survival. Read More

Mayo Clin Proc 2022 Jun;97(6):1209-1210

Department of Pathology, Kanazawa Municipal Hospital, Kanazawa, Ishikawa, Japan.

Biol Open 2022 Jun 6. Epub 2022 Jun 6.

Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.

Epidemiological observations have prompted some to posit that elevated circulating vitamin D is responsible for reduced colon cancer in individuals residing near the equator. We have previously demonstrated that vitamin D has no effect on colon cancer in two rodent models of intestinal tumorigenesis. We have now extended this line of inquiry to ask whether ablation of vitamin D receptor (VDR) affects tumorigenesis. Read More

J Immunol Res 2022 24;2022:9019097. Epub 2022 May 24.

Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Aims: To explore the expression of circular RNA (circRNA) in gastrointestinal stromal tumors.

Background: Gastrointestinal stromal tumors (GIST) are mainly distributed in the stomach and small intestine. Recently, it has been verified that circular RNA (circRNA) has an important function in the regulation of GIST. Read More

Ulus Travma Acil Cerrahi Derg 2022 Jun;28(6):879-883

Department of General Surgery, Trakya University Faculty of Medicine, Edirne-Turkey.

Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant disorder which is characterized by hyperpigmentation in mucocutaneous membranes and hamartomatous polyps in the gastrointestinal tract (GIT). Common complications reported in patients with PSJ are bleeding and mechanical intestinal obstruction due to the hamartomatous polyps. There is also an increased risk of gastrointestinal and extra-intestinal malignancies in patients with PJS. Read More

Gastroenterology 2022 May 25. Epub 2022 May 25.

Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Milan, Italy; IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy. Electronic address:

Background And Aims: To summarize the epidemiological evidence and assess the validity of claimed associations of inflammatory bowel diseases (IBD) with overall and site-specific cancer risk.

Methods: We systematically searched PubMed, Embase and Scopus from inception to May 10, 2021 to identify and comprehensively re-analyze the data of meta-analyses on associations between IBD (i.e. Read More

Anticancer Res 2022 Jun;42(6):3169-3176

Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.

Background/aim: Increased serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA19-9) are established prognostic factors in ampulla of Vater carcinoma (AC). We determined the best cut-off values of preoperative CEA and CA19-9 and compared the prognostic power of preoperative CEA with that of preoperative CA19-9 for overall survival (OS).

Patients And Methods: A total of 116 consecutive patients without jaundice who underwent macroscopic curative resection for AC between January 2002 and August 2019 were enrolled. Read More

Arkh Patol 2022 ;84(3):52-59

B.V. Petrovsky Russian Research Center of Surgery, Moscow, Russia.

A case of a mature anterior mediastinal teratoma with a predominance of the pancreatic component (80% of the tumor) and signs of nesidioblastosis in a 46-year-old woman is presented. During histological examination, all components of the pancreatic parenchyma were determined - acini with interlobular and intralobular ducts, endocrine cells and islets of Langerhans of various sizes and shapes, as well as islet-duct complexes scattered in the acinar tissue. In addition to pancreatic tissue, cartilage, bronchial respiratory epithelium, small intestine tissue, hair follicles, and sebaceous glands were found in the neoplasm. Read More

World J Gastroenterol 2022 May;28(17):1845-1859

Department of Internal Medicine, Hanyang University College of Medicine, Seoul 04763, South Korea.

Background: Ampullary adenoma is a rare premalignant lesion, but its incidence is increasing. Endoscopic papillectomy has become the first treatment of choice for ampullary adenomas due to its safety and effectiveness, thereby replacing surgical resection. However, recurrence rates and adverse events after endoscopic papillectomy were reported in up to 30% of cases. Read More

Wiad Lek 2022 ;75(4 pt 2):1039-1042

BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE.

The given paper describes a case of treating adenocarcinoma of the papilla of Vater diagnosed as the cause after an episode of acute pancreatitis. The etiology of aсute pancreatitis was considered idiopathic until the onset of complaints caused by tumor growth. The volume of radical surgery has changed intraoperatively due to the detection of infected limited necrotic clusters, didn't diagnosed both laboratory and instrumentally. Read More

Rev Gastroenterol Peru 2021 Oct-Dec;41(4):215-220

Hospital Nacional Guillermo Almenara Irigoyen. Lima, Perú.

Introduction: Primary tumors of the small intestine (PTID) represent approximately 5% of all primary gastrointestinal neoplasms; the latter include benign and malignant lesions, with different histological subtypes.

Objective: To describe the clinical-pathological characteristics and the management of tumors located in the jejunum-ileum.

Materials And Methods: A descriptive, retrospective study was carried out in a single center. Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221100500

Department of Obstetrics and Gynecology, South Georgia Medical Center, Valdosta, GA, USA.

Small bowel obstruction is a common surgical emergency and frequent cause of hospitalization. Internal hernias account for less than 6% of all small bowel obstruction cases. Less frequently, hernias through the broad ligament of the uterus can occur and account for only 4-7% of total internal hernia cases. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2022 May;25(5):392-395

Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, China.

There still remain some problemsin digestive tract reconstruction after robotic radical gastrectomy for gastric cancer at present, such as great surgical difficulties and high technical requirements. Based on the surgical experience of the Gastric Surgery Department of Union Hospital, Fujian Medical University and the literatures at home and abroad, relevant issues are discussed in terms of robotic radical distal gastrectomy (Billroth I, Billroth II, and Roux-en-Y gastrojejunostomy), proximal gastrectomy (double-channel and double-muscle flap anastomosis), and total gastrectomy (Roux-en-Y anastomosis, functional end-to-end anastomosis, FEEA, π-anastomosis, Overlap anastomosis, and modified Overlap anastomosis with delayed amputation of jejunum, i.e. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2022 May;25(5):378-384

Department of General Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi'an 710038, China.

With the development of instrument, equipment and surgical skills, especially the emergence of a series of high-level medical evidence, the laparoscopic techniques in the field of gastric surgery has been further expanded. Totally laparoscopic total gastrectomy (TLTG) has certain technical difficulties, and more challenges are reflected in the digestive tract reconstruction. The use of linear staplers has reduced the difficulty of digestive tract reconstruction to a certain extent and has strongly promoted the transition from laparoscopic-assisted total gastrectomy to TLTG. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2022 May;25(5):367-372

Department of General Surgery, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.

Laparoscopic techniques are more and more poplular in proximal gastrectomy. The traditional esophagogastric anastomosis may lead to severe reflux esophagitis after surgery, affecting patient's quality of life. In recent years, multiple methods of digestive tract reconstruction after laparoscopic proximal gastrectomy capable of resisting reflux have been applied to the clinic. Read More

Sci Rep 2022 May 21;12(1):8589. Epub 2022 May 21.

Academy of Medical, Changchun Sci-Tech University, Changchun, China.

Hepatocellular carcinoma (HCC) is a common type of cancer-prevalent worldwide-and one of the causes of cancer-related deaths. In this study, ethanol extracts from Pholiota adiposa (EPA) were used to identify possible targets for HCC treatment and their effects on intestinal microflora were analyzed. Methods: Male mice were randomly assigned to groups-the model group, cyclophosphamide (25 mg/kg/d), and EPA groups, in which the mice were categorized based on the different concentrations of each compound (100, 200, and 300 mg/kg/day). Read More

Khirurgiia (Mosk) 2022 (5):25-33

National Medical Research Centre for Oncology, Rostov-on-Don, Russia.

Objective: To analyze the issue of gastrointestinal stromal tumors (GISTs) and potential of minimally invasive surgical interventions.

Material And Methods: We analyzed postoperative outcomes in 97 patients with gastric and intestinal GISTs who underwent surgical treatment at the National Medical Research Centre for Oncology between 2015 and 2020.

Results: Twenty (24. Read More