28,366 results match your criteria Benign Neoplasm of the Small Intestine


Perforated Ileal GIST Associated with Meckel Diverticulum - A Rare Pathological Entity of Surgical Acute Abdomen.

Chirurgia (Bucur) 2020 May-Jun;115(3):404-409

The GIST tumors are very rare entities ( 1% of all tumors). They originate in the Cajal interstitial cells, which are part of the autonomic nervous system of the intestine. Their most common location is the stomach, followed by the small intestine. Read More

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http://dx.doi.org/10.21614/chirurgia.115.3.404DOI Listing

[Metastasis of clear cell renal cell carcinoma into small bowel in 5 years after nephrectomy].

Khirurgiia (Mosk) 2020 (6):118-120

Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Small bowel tumor causes gastrointestinal bleeding in 1-4% of cases. Gastrointestinal bleeding from metastases of renal cell carcinoma is a rare and little-known manifestation of this disease. We report a rare clinical case of a solitary metastasis of clear cell renal cell carcinoma into small bowel in 5 years after nephrectomy. Read More

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http://dx.doi.org/10.17116/hirurgia2020061118DOI Listing

Epstein-Barr Virus-negative Marginal Zone Lymphoma as an Uncommon Form of Monomorphic Posttransplant Lymphoproliferative Disorder.

Am J Surg Pathol 2020 Jun 16. Epub 2020 Jun 16.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD.

Monomorphic posttransplant lymphoproliferative disorders have been defined as lymphoid or plasmacytic proliferations that fulfill criteria for one of the B-cell or T/NK-cell neoplasms recognized in immunocompetent hosts in the current WHO Classification. Low-grade B-cell neoplasms have historically been excluded from this category, although rare reports of marginal zone lymphoma (MZL) have been described. We report 9 cases of posttransplant Epstein-Barr virus-negative MZL, all arising in solid organ transplant recipients (4 renal, 3 liver, 1 cardiac, and 1 liver, pancreas, and small bowel). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001514DOI Listing

Pathogenesis and Clinical Management of Mesenteric Fibrosis in Small Intestinal Neuroendocine Neoplasms: A Systematic Review.

J Clin Med 2020 Jun 8;9(6). Epub 2020 Jun 8.

1st Department of Propaedeutic Internal Medicine, Endocrine Unit, National and Kapodistrian, University of Athens, 11527 Athens, Greece.

Mesenteric fibrosis (MF) constitutes an underrecognized sequela in patients with small intestinal neuroendocrine neoplasms (SI-NENs), often complicating the disease clinical course. The aim of the present systematic review, carried out by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, is to provide an update in evolving aspects of MF pathogenesis and its clinical management in SI-NENs. Complex and dynamic interactions are present in the microenvironment of tumor deposits in the mesentery. Read More

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http://dx.doi.org/10.3390/jcm9061777DOI Listing

Detection of microsatellite instability in a panel of solid tumours with the Idylla MSI Test using extracted DNA.

J Clin Pathol 2020 Jun 8. Epub 2020 Jun 8.

Department of Pathology, CHU Henri Mondor, Créteil, France

Aim: During the last few years, determination of microstatellite instability (MSI) status has become a routine part of clinical practice, essentially to detect Lynch syndrome. Recently, MSI testing has increased with the development of immunotherapy and has expanded to a large panel of solid tumours. The aim of our work was to evaluate a fully automated system developed by Biocartis, the Idylla MSI Test, which performs an MSI analysis within 150 min. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206581DOI Listing

Ileo-ileal intussusception caused by small bowel leiomyosarcoma: A rare case report.

Int J Surg Case Rep 2020 May 29;72:52-55. Epub 2020 May 29.

Colorectal Surgery Unit, Università Campus Bio-Medico, Rome, Italy.

Introduction: Intussusception is the telescoping of one segment of the bowel into an adjacent bowel segment, causing venous congestion, edema, and blood supply reduction. We present a case of ileo-ileal intussusception in an adult patient with intestinal obstruction caused by a rare mesenchymal malignant lesion of the distal ileum: Leiomyosarcoma (LMS).

Presentation Of Case: A 90-year-old Caucasian man presented to the hospital with a two-day history of abdominal pain, nausea, and bowel occlusion. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283087PMC

Type II enteropathy-associated T cell lymphoma in the duodenum: A rare case report.

Medicine (Baltimore) 2020 Jun;99(23):e20050

Department of Gastroenterological Surgery.

Introduction: Enteropathy-associated T-cell lymphoma (EATL) is a very rare form of lymphoma in the gastrointestinal tract. The proximal jejunum and ileum are the most common sites of EATL, whereas EATL rarely arises in the duodenum, and EATL involving metastasis of the bilateral ovaries is even rarer.

Patient Concerns: A 43-year-old female suffered from upper abdominal pain and weight loss for 3 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000020050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306349PMC
June 2020
5.723 Impact Factor

A Rare Case of Well-Differentiated Neuroendocrine Tumor Arising From a Jejunal Pancreatic Heterotopia.

Int J Surg Pathol 2020 Jun 2:1066896920928126. Epub 2020 Jun 2.

Washington University in St. Louis, MO, USA.

Pancreatic heterotopia is a well-described entity occurring at multiple abdominal sites, most commonly the stomach and small intestine. They can develop similar disease processes as the pancreas ranging from acute pancreatitis, cyst formation, or neoplasms, most commonly ductal adenocarcinoma. Neuroendocrine tumors (NETs) arising in pancreatic heterotopias are exceedingly rare with only 3 prior published cases. Read More

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http://dx.doi.org/10.1177/1066896920928126DOI Listing

Chemotherapy for patients with unresectable or metastatic small bowel adenocarcinoma: a systematic review.

Int J Clin Oncol 2020 May 24. Epub 2020 May 24.

Department of Health Informatics, Kyoto University School of Public Health, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.

Background: There is no standard chemotherapy available for unresectable or metastatic small bowel adenocarcinoma (SBA) because of its rarity. This systematic review aims to assess the efficacy and safety of chemotherapy for patients with unresectable or metastatic SBA.

Methods: In accordance with the PRISMA statements, literature search was conducted using PubMed, Scopus, and the Cochrane Central Register of Controlled Trials. Read More

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http://dx.doi.org/10.1007/s10147-020-01703-zDOI Listing

Evaluation of the expression of somatostatin receptors by immunohistochemistry in neuroendocrine tumors of the small intestine.

Authors:

Pol J Pathol 2020 ;71(1):30-37

Most neuroendocrine neoplasms (NEN) are characterized by the presence of somatostatin receptors (SSTR) which we use in location diagnostics and treatment. The aim of this study was to evaluate the expression of somatostatin receptors by immunohistochemistry in tissue obtained after surgery of the primary focus in the small intestine. The group of patients consisted of 41 people, in 18 cases the primary tumor was in the jejunum and in 23 in the ileum. Read More

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http://dx.doi.org/10.5114/pjp.2020.95413DOI Listing
January 2020

Neuroendocrine Tumors of the Pancreatobiliary and Gastrointestinal Tracts.

Surg Clin North Am 2020 Jun 1;100(3):635-648. Epub 2020 Apr 1.

Section of General, Vascular, and Thoracic Surgery, Virginia Mason Medical Center, 1100 Ninth Avenue, CS-G6, Seattle, WA 98101, USA; University of Washington, Seattle, WA, USA. Electronic address:

Incidence of neuroendocrine tumors (NETs) is increasing, including those of the gastroenteropancreatic tract. A proper understanding of the management of this disease has become necessary for the general surgeon. This article addresses current guidelines for diagnosis and localization of NETs, including somatostatin receptor PET. Read More

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http://dx.doi.org/10.1016/j.suc.2020.02.010DOI Listing

[Heterogeneity in PD-L1 expression on infiltrating immune cells between the primary and metastatic breast cancers].

Zhonghua Bing Li Xue Za Zhi 2020 May;49(5):430-434

Department of Pathology, the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011, China.

To investigate the expression difference in PD-L1 on mesenchymal infiltrating immune cells between the primary and metastatic breast cancers, and to explore its relationship with clinicopathological parameters. All cases of primary breast cancer and their matched metastases diagnosed at the Fourth Hospital of Hebei Medical University between January 2010 and December 2018 were included. Immunohistochemistry (IHC) was used to detect the expression of PD-L1 (SP142) in interstitial infiltrating immune cells, and the expression of ER, PR, HER2 and Ki-67 in primary and matched metastases was detected. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20200225-00137DOI Listing

A rare case of jejunal gastrointestinal stromal tumor.

Ann Ital Chir 2019 Dec 20;8. Epub 2019 Dec 20.

Gastrointestinal stromal tumors(GISTs) are rare neoplasms of the gastrointestinal(GI) system originating from the mesenchyme. GISTs mostly develop in the stomach and small intestine. We present here a case of jejunal GIST which is the rarest subtype. Read More

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December 2019

Impact of Cytoreductive Surgery and HIPEC on Intraoperative Gastrointestinal Wall Thickness and Patient Outcomes.

Anticancer Res 2020 May;40(5):2865-2869

Department of Surgery, St. George Hospital, Kogarah, NSW, Australia

Background: Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) is associated with significant postoperative ileus (POI). This study examined intraoperative gastrointestinal wall thickness (GWT) and its association with patient outcomes.

Patients And Methods: A prospective study of patients undergoing CRS and HIPEC. Read More

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http://dx.doi.org/10.21873/anticanres.14262DOI Listing

[Comparative analysis of radical surgical treatment of periampullary tumors].

Khirurgiia (Mosk) 2020 (4):24-29

Syzganov National Research Centre of Surgery, Almaty, Republic of Kazakhstan.

Objective: Retrospective analysis of patients with periampullary tumors undergoing pancreatoduodenectomy.

Material And Methods: A retrospective review included 48 patients with resectable periampullary tumors. Patients were divided into two groups according to the localization of cancer. Read More

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http://dx.doi.org/10.17116/hirurgia202004124DOI Listing

[Comparison of efficiency and safety of laparoscopic manual esophagoenterostomy and esophagoenterostomy with mechanical anastomotic devices after laparoscopic gastrectomy for stomach cancer].

Khirurgiia (Mosk) 2020 (4):11-17

Lomonosov Moscow State University, Faculty of Fundamental Medicine, Moscow, Russia.

Objective: To compare laparoscopic manual esophagoenterostomy and esophagoenterostomy with mechanical stapling anastomotic devices after laparoscopic gastrectomy for stomach cancer.

Material And Methods: There were 34 patients who underwent laparoscopic gastrectomy for stomach in 2015-2018. Roux-en-Y esophagoenterostomy was used to reconstruct the gastrointestinal tract. Read More

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http://dx.doi.org/10.17116/hirurgia202004111DOI Listing

Laparoscopic repair of a giant hiatal hernia after minimally invasive oesophagectomy.

Ann R Coll Surg Engl 2020 Jul 24;102(6):e130-e132. Epub 2020 Apr 24.

Parma University Hospital, Parma, Italy.

Minimally invasive oesophagectomy has become popular, but studies showed a higher rate of postoperative hiatus hernia compared with open oesophagectomy. Our video presents the laparoscopic biosynthetic mesh repair of a symptomatic giant hiatus hernia in a 71-year-old man who had undergone minimally invasive oesophagectomy one year earlier for distal adenocarcinoma of the oesophagus. The operative time was 120 minutes. Read More

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http://dx.doi.org/10.1308/rcsann.2020.0049DOI Listing

[A rare case of cystadenoma in the small intestine].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):382-384

Department of Oncology, Hebei Hosptical of Traditional Chinese Medicine Affiliated to Hebei University of Traditional Chinese Medicine, Shijiazhuang 050011, China.

In recent years, there have been more and more reports about cystadenoma. Cystadenoma can occur in many parts of the body, and cystadenoma in different parts may show different clinical symptoms, however, some patients with cystadenoma have no symptoms. The vast majority of cystadenomas are benign lesions, but a small number of cystadenomas can be malignant. Read More

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DUODENAL DUPLICATION CYST WITH ENTEROLITHS DIAGNOSED BY ECHOENDOSCOPY AND TREATED BY ENDOSCOPIC MARSUPIALIZATION.

Arq Gastroenterol 2020 Jan-Mar;57(1):110-111

Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Cirurgia e Anatomia; HCFMRP-USP, Ribeirão Preto, SP, Brasil.

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http://dx.doi.org/10.1590/S0004-2803.202000000-19DOI Listing

[Acute complications of gastrointestinal stromal tumors].

Khirurgiia (Mosk) 2020 (3):67-73

Chita State Medical Academy of the Ministry of Health of Russia, Chita, Russia.

Objective: To analyze acute complications of stromal gastrointestinal tumors and determine diagnosis and optimal treatment of these patients.

Material And Methods: There were 33 patients with acute complications of GIST aged 40-74 years.

Results: Acute complications were presented by gastrointestinal and (or) intratumoral (interstitial) bleeding (n=31). Read More

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http://dx.doi.org/10.17116/hirurgia202003167DOI Listing

Association Between Celiac Disease and Mortality Risk in a Swedish Population.

JAMA 2020 04;323(13):1277-1285

Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York, New York.

Importance: Celiac disease may be associated with a modest but persistent increased long-term mortality risk. It is uncertain whether this risk has changed in the era of wider diagnosis rates, less severe clinical disease, and more widespread availability of gluten-free food.

Objective: To evaluate the association between celiac disease and mortality risk in a population-based cohort in Sweden. Read More

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http://dx.doi.org/10.1001/jama.2020.1943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139272PMC

Oxidative-stress-driven mutagenesis in the small intestine of the gpt delta mouse induced by oral administration of potassium bromate.

Mutat Res 2020 Feb - Mar;850-851:503136. Epub 2020 Jan 15.

National Institute of Health Sciences, Division of Genetics and Mutagenesis, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan.

Tumorigenesis induced by oxidative stress is thought to be initiated by mutagenesis, but via an indirect mechanism. The dose-response curves for agents that act by this route usually show a threshold, for unknown reasons. To gain insight into these phenomena, we have analyzed the dose response for mutagenesis induced by the oral administration of potassium bromate, a typical oxidative-stress-generating agent, to gpt delta mice. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2020.503136DOI Listing

Difference of computed tomographic characteristic findings between gastric and intestinal gastrointestinal stromal tumors.

Jpn J Radiol 2020 Apr 4. Epub 2020 Apr 4.

Department of Radiology, Shiga University of Medical Science, Seta, Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

Purpose: We aimed to compare the computed tomography (CT) imaging differences between gastric and intestinal gastrointestinal stromal tumors (GISTs).

Materials And Methods: Thirty-eight patients with 38 gastric GISTs and 27 with 31 intestinal GISTs were enrolled. Tumors were classified as small (< 5 cm) or large (≥ 5 cm). Read More

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http://dx.doi.org/10.1007/s11604-020-00962-0DOI Listing

Upfront Surgery for Small Intestinal Non-Hodgkin's Lymphoma.

Anticancer Res 2020 Apr;40(4):2373-2377

Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.

Background/aim: The clinical significance of surgery for secondary small intestinal non-Hodgkin's lymphomas (NHL) remains unknown. This study aimed to investigate the efficacy of resection for both primary and secondary small intestinal NHL.

Patients And Methods: Twenty patients with small intestinal lymphoma who underwent surgical resection at our Institute between 2009 and 2017 were retrospectively evaluated. Read More

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http://dx.doi.org/10.21873/anticanres.14206DOI Listing

[Successful intraductal radiofrequency ablation of residual adenoma tissue following endoscopic papillectomy].

Z Gastroenterol 2020 Mar 20;58(3):241-244. Epub 2020 Mar 20.

Klinik für Innere Medizin und Gastroenterologie, Rhein-Maas-Klinikum, Würselen, Germany.

Treatment of adenoma of the major duodenal papilla is often a challenge for the endoscopist. We report about two patients with papillary adenoma who had residual adenoma in the center of the ductus hepatocholedochus papillary region after endoscopic papillectomy. Due to missing possibility of further endoscopic resection we carried out endobiliary radiofrequency ablation instead of surgical treatment. Read More

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http://dx.doi.org/10.1055/a-1096-1592DOI Listing

[Bacillus pumilus Ribonuclease Inhibits Migration of Human Duodenum Adenocarcinoma HuTu 80 Cells].

Mol Biol (Mosk) 2020 Jan-Feb;54(1):146-152

Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, 420008 Russia.

Migration of cancer cells from the primary tumor site to nearby tissues is the starting point of the metastatic process. The invasive properties of cells are especially important for carcinomas, since tumor cells need to overcome the basement membrane and go beyond its boundaries to the underlying tissues. Substances that reduce the invasive ability of malignant cells are promising as antimetastatic agents. Read More

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http://dx.doi.org/10.31857/S0026898420010176DOI Listing

[A Case of Perforated Intestinal Malignant Lymphoma Induced to Remission by Multidisciplinary Therapy].

Gan To Kagaku Ryoho 2019 Dec;46(13):1972-1974

Dept. of Surgery, Japanese Red Cross Hadano Hospital.

A 61-year-old man had a sudden severe abdominal pain and visited our hospital. He was diagnosed with intestinal perforation, given the peritoneal irritation symptoms, the thickening of the intestinal wall and free air as shown on enhanced abdominal computed tomography. He then underwent emergent surgery. Read More

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December 2019

[A Case of Extraosteosarcoma in the Omentum].

Gan To Kagaku Ryoho 2019 Dec;46(13):1945-1947

Dept. of Surgery, Kyoundo Hospital.

A 51-year-old female presented to our hospital with a chief complaint of abdominal pain. A blood test showed high ALP value(7,001 IU/L), and the abdominal CT showed a mass lesion of 20 cm in diameter with calcification and infiltrated surroundings. From these findings, we diagnosed the patient with peritonealcancer pre-operatively. Read More

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December 2019

[A Case of Gastrointestinal Stromal Tumor Re-Resected Ten Years after the Resection of Its Recurrence].

Gan To Kagaku Ryoho 2019 Dec;46(13):1943-1944

Dept. of Surgery, Chiba Kaihin Municipal Hospital.

The patient was a 75-year-old man who was diagnosed as having jejunal gastrointestinal stromal tumor(GIST)and underwent partial resection of the small intestine including the tumor 12 years ago. Two years after the first resection, recurrence was detected, and a second resection was performed. Ten years after the second resection following recurrence, he took imatinib, and computed tomography(CT)revealed abdominal and liver tumors. Read More

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December 2019

[Long-Term Survival after Surgical Treatment of Neuroendocrine Carcinoma of the Ampulla of Vater-A Case Report].

Gan To Kagaku Ryoho 2019 Dec;46(13):2586-2588

Dept. of Surgery, Toyonaka Municipal Hospital.

A 60s man underwent upper gastrointestinal endoscopy at a regular medical check-up without symptoms, which showed an ulcerative region in the duodenal ampulla, measuring 3 cm in diameter. He was diagnosed with poorly differentiated adenocarcinoma on biopsy and referred to our hospital. Abdominal contrast-enhanced CT scan revealed an enhanced-ulcerative tumor, measuring 3 cm, at the duodenal ampulla. Read More

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December 2019

[Colorectal Cancer Associated with Crohn's Disease-A Case Report].

Gan To Kagaku Ryoho 2019 Dec;46(13):2515-2517

Dept. of Gastrointestinal and Pediatric Surgery, Tokyo Medical University Hospital.

We report a case of colorectal cancer associated with Crohn's disease in a 50-year-old man. He had been diagnosed with Crohn's disease 26 years before and had undergone sigmoidectomy for sigmoid colon stenosis 19 years before. Ileal resection, was performed for ileus stenosis 12 years before. Read More

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December 2019

[A Case of Omental Desmoid Tumor after a Small Bowel Resection for Gastrointestinal Stromal Tumor].

Gan To Kagaku Ryoho 2019 Dec;46(13):2488-2490

Dept. of Surgery, Osaka General Hospital of West Japan Railway Company.

An intra-abdominaldesmoid tumor, especially omentaldesmoid tumor, is rare. Here, we report a case of omentaldesmoid tumor after a smallbowelresection for gastrointestinalstromaltumor (GIST). A 73-year-old man underwent a partial resection of smallbowelfor GIST. Read More

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December 2019

[A Case of Peritoneal Metastasis Resection from GIST of the Small Intestine with Focal Resistance Against Imatinib Mesylate].

Gan To Kagaku Ryoho 2019 Dec;46(13):2452-2454

Dept. of Surgery, Tohoku University Graduate School of Medicine.

A 69-year-old man was referred to our institute for the surgical resection of focal resistant peritoneal GIST during imatinib administration. He had been diagnosed with GIST of the small intestine with liver and peritoneal metastases, and imatinib treatment was initiated. Shortly after imatinib administration, the primary lesion perforated, and thus, partial resection of the small intestine was performed. Read More

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December 2019

[A Case of Liver Metastases of Ampullary Carcinoma with Clinical Complete Response Treated with Gemcitabine plus Cisplatin].

Gan To Kagaku Ryoho 2019 Dec;46(13):2357-2359

Dept. of Surgery, Kansai Rosai Hospital.

We report a case of liver metastases of ampullary carcinoma that achieved clinical complete response after gemcitabine plus cisplatin(GC)combination chemotherapy. A 69-year-old man with obstructive jaundice was diagnosed with ampullary carcinoma and underwent laparoscopic pancreaticoduodenectomy. Postoperative histopathological examination revealed pT3aN0M0, Stage ⅡA adenocarcinoma of the papilla of Vater. Read More

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December 2019

[A Case of Long-Term Survival of a Postoperative Recurrence of Duodenal Papilla Adenosquamous Carcinoma Associated with the Annular Pancreas].

Gan To Kagaku Ryoho 2019 Dec;46(13):2336-2338

Dept. of Surgery, Shuuwa General Hospital.

A woman in her mid-50's presented to our hospital with jaundice, fatigue, and fever. Jaundice, elevated tumor markers, and lower bile duct stricture suggested malignancy, for which subtotal stomach-preserving pancreaticoduodenectomy was performed. The patient also had annular pancreas as the second part of the duodenum was surrounded by pancreatic parenchyma. Read More

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December 2019

[A Resected Case of Retroperitoneal Metastasis and Small Bowel Metastasis from HCC].

Gan To Kagaku Ryoho 2019 Dec;46(13):2297-2299

Dept. of Surgery, Osaka City Juso Hospital.

A 71-year-old man underwent right hemi-hepatectomyfor a hepatocellular carcinoma(HCC)measuring 18 cm in diameter. The pathological diagnosis was poorlydifferentiated HCC. Ten months after the surgery, computed tomographyrevealed a nodule 12mm in diameter in the right lung as well as 2 nodules measuring 19 and 11mm in diameter in the retroperitoneum at the cranial aspect of the left kidney. Read More

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December 2019

[Small Intestinal Metastasis from Lung Cancer with Infiltration into Other Organs-Review of the Literature].

Gan To Kagaku Ryoho 2019 Dec;46(13):2234-2236

Dept. of Gastroenterological Surgery, Iseikai Hospital.

We report a case of metastasis to the small intestine from squamous cell carcinoma of the lung with fistula formation in the adjacent small intestine as well as an analysis of reported cases in Japan of small intestinal metastasis from lung cancer invading other organs. A 63-year-old man was diagnosed with squamous cell carcinoma of the lung as a result of pneumonia. Chemoradiotherapy was administered and sequential chemotherapy was performed, but a single brain metastasis of right parietal lobe was detected 6 months later. Read More

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December 2019

[Anastomotic Recurrence after Curative Resection for Transverse Colon Cancer-A Case Report].

Gan To Kagaku Ryoho 2019 Dec;46(13):2216-2218

Dept. of Surgery, National Hospital Organization Fukuyama Medical Center.

The rate of local and anastomotic recurrence after curative resection for colon cancer is quite low, at 2.1%. We describe an anastomotic recurrence that rapidly increased after transverse colon cancer resection. Read More

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December 2019

[A Case Report of Gastrointestinal Bleeding with Difficulty in Diagnosis].

Gan To Kagaku Ryoho 2019 Dec;46(13):2134-2136

Dept. of Surgery, Saiseikai Yahata General Hospital.

The authors report a case involving a 55-year-old female patient who presented with melena and anemia 8 years ago. Esophagogastroduodenoscopy, colonoscopy, and CT did not reveal any sign of lesions except multiple uterine myoma. On reevaluation after the onset of melena, we did not find any lesions. Read More

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December 2019

[A Case of Jejunal Ectopic Pancreatic Cancer with Intestinal Perforation].

Gan To Kagaku Ryoho 2019 Dec;46(13):2122-2124

Dept. of Surgery, Sasebo Chuo Hospital.

This patient was a 96-year-old woman. She was referred to our hospital with abdominal pain and vomiting. The levels of the tumor markers CEA and CA19-9 were elevated, at 39. Read More

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December 2019

Colonic Goblet Cell Carcinoid: Rarity of a Rarity! A Case Report and Review of Literature.

Chirurgia (Bucur) 2020 Jan-Feb;115(1):102-111

Goblet cell carcinoids (GCC) are extremelyrare neuroendocrine tumours, and characterised by their unique combination of two types of cancer cells âÃÂ" neuroendocrine (carcinoid) and epithelial (adeno-carcinoma). In spite of the fact that GCC is regarded as Neuro-Endocrine Tumour (NET), it does not illicit carcinoid syndrome. GCC usually arises in the appendix and accounting for less than 14% of all appendiceal tumours. Read More

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http://dx.doi.org/10.21614/chirurgia.115.1.102DOI Listing

In Search of the Optimal Reconstruction Method after Total Gastrectomy. Is Roux-en-Y the Best? A Review of the Randomized Clinical Trials.

Chirurgia (Bucur) 2020 Jan-Feb;115(1):12-22

Numerous procedures for reconstruction after total gastrectomy have been proposed in order to achieve the lowest postoperative morbidity. Roux-en-Y esojejunostomy is widely accepted as a standard reconstruction technique due to its simplicity and its satisfactory nutritional outcomes. The construction of a gastric pouch and the maintenance of the duodenal transit have been proposed to ameliorate the quality of life of patients with gastric cancer. Read More

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http://dx.doi.org/10.21614/chirurgia.115.1.12DOI Listing

Intramural hematoma of colon: Case report of 2 cases.

Medicine (Baltimore) 2020 Mar;99(10):e19404

Department of Radiology, First Hospital of Jilin University, Changchun, Jilin Province, China.

Introduction: Colonic intramural hematomas are rarely encountered clinical entity. Colonic intramural hematomas are frequently associated with blunt trauma, and they could occur spontaneously in patients under anticoagulant therapy or with bleeding diathesis. There were few reports on synchronous colon cancer and intramural hematoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000019404DOI Listing
March 2020
5.723 Impact Factor

Neuroendocrine metastases to the ovaries are significantly associated with small bowel neuroendocrine tumors and carcinomatosis.

Am J Surg 2020 05 25;219(5):795-799. Epub 2020 Feb 25.

Division of Surgical Oncology, Oregon Health & Science University, USA. Electronic address:

Introduction: Neuroendocrine tumors (NETs) metastatic to the ovary are traditionally considered rare, but data are lacking. This study seeks to better characterize the prevalence and outcomes of patients with neuroendocrine ovarian metastases (NOM).

Methods: Women with well-differentiated lung and gastroenteropancreatic NETs 2007-2017 were identified by medical record query. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.02.040DOI Listing

Modified delta-shaped gastroduodenostomy consisting of linear stapling and single-layer suturing with the operator positioned between the patient's legs: A technique preventing intraoperative duodenal injury and postoperative anastomotic stenosis.

PLoS One 2020 6;15(3):e0230113. Epub 2020 Mar 6.

Department of Surgery, Otori Stomach and Intestines Hospital, Osaka, Japan.

Background: The drawback of the delta-shaped gastroduodenostomy (DSG) in totally laparoscopic distal gastrectomy (TLDG) is the presence of intraoperative duodenal injury and postoperative anastomotic stenosis, which can occur due to a relatively short duodenal bulb diameter.

Materials And Methods: From June 2013 to June 2019, 35 patients with gastric cancer underwent TLDG with a modified DSG consisting of linear stapling and single-layer hand suturing in our institution. All anastomotic procedures were performed by the right hand of the operator positioned between the patient's legs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230113PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059953PMC

Preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer.

PLoS One 2020 3;15(3):e0229597. Epub 2020 Mar 3.

Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, South Korea.

Introduction: Prognostic nutritional index (PNI) reflects the nutritional and immunologic status of the patients. The clinical application of PNI is already well-known in various kinds of solid tumors. However, there is no study investigating the relationship between PNI and oncological outcome of the resected ampulla of Vater (AoV) cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229597PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053754PMC

[Application of laparoscopic exploration combined with abdominal exfoliative cytology in the diagnosis and treatment of locally advanced gastric cancer].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Feb;23(2):170-176

The Third Department of Surgery, The Fourth Hospital, Hebei Medical University, Shijiazhuang 050017, China.

To explore the clinical significance of laparoscopic exploration combined with abdominal exfoliative cytology in the diagnosis and treatment of patients with locally advanced gastric cancer. Inclusion criteria: (1) cancer confirmed by gastroscopy and pathology without preoperative anti-tumor treatment; (2) no distant metastases found in preoperative imaging examinations; (3) patients without surgical contraindications and being tolerant to surgery; (4) patients were willing to undergo laparoscopic exploration and abdominal exfoliative cytology examination, and signed informed consent. A retrospective cohort study method was used to collect and analyze the clinicopathological data of 225 patients with advanced gastric cancer based on the above inclusion criteria from a prospective, multicenter, open, randomized controlled phase III clinical trial (registration No. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1671-0274.2020.02.013DOI Listing
February 2020

Cell-type-specific signaling networks in heterocellular organoids.

Nat Methods 2020 03 17;17(3):335-342. Epub 2020 Feb 17.

Cell Communication Lab, Department of Oncology, University College London Cancer Institute, London, UK.

Despite the widespread adoption of organoids as biomimetic tissue models, methods to comprehensively analyze cell-type-specific post-translational modification (PTM) signaling networks in organoids are absent. Here, we report multivariate single-cell analysis of such networks in organoids and organoid cocultures. Simultaneous analysis by mass cytometry of 28 PTMs in >1 million single cells derived from small intestinal organoids reveals cell-type- and cell-state-specific signaling networks in stem, Paneth, enteroendocrine, tuft and goblet cells, as well as enterocytes. Read More

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http://dx.doi.org/10.1038/s41592-020-0737-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060080PMC
March 2020
32.072 Impact Factor

Impact of 68Ga-DOTATOC PET/CT in comparison to 111In-Octreotide SPECT/CT in management of neuro-endocrine tumors: A case report.

Medicine (Baltimore) 2020 Feb;99(7):e19162

Department of Pharmacy-Pharmaceutical Sciences, University of Bari, Bari, Italy.

Rationale: In the diagnostics of neuroendocrine tumors (NETs), scintigraphy and Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) with Indium-Octreotide occupy a prominent place.The introduction in clinical practice of Gallium-labelled somatostatin analogues (DOTA-TOC, DOTA-TATE, DOTA-NOC) for Positron Emission Tomography/Computed Tomography (PET/CT), significantly improved NETs diagnostics due to greater sensitivity and improved lesion detection in addition to better patient convenience and decreased radiation dose.

Patient Concerns: We report a case of a patient who was diagnosed with a neuroendocrine tumor of the ileocecal valve. Read More

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http://dx.doi.org/10.1097/MD.0000000000019162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035109PMC
February 2020