8,866 results match your criteria Benign Lung Tumors


Increased Galectin-1 Expression in Thymic Epithelial Tumors.

Clin Lung Cancer 2018 Dec 21. Epub 2018 Dec 21.

Department of Radiation Oncology, Stanford University School of Medicine Stanford Cancer Institute, Stanford, CA.

Introduction: Thymic epithelial tumors (TET) are rare malignancies with a paucity of data on biology and therapeutics. Galectin-1 is a member of the β-galactoside binding protein family and has been shown to mediate tumor growth via modulation of immune cell function. This study examined galectin-1 expression in TET. Read More

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http://dx.doi.org/10.1016/j.cllc.2018.12.005DOI Listing
December 2018

Clinicopathological Features and Treatment Outcomes of Solid Pseudopapillary Neoplasms of the Pancreas: A 10-Year Case Series from a Single Center.

J Laparoendosc Adv Surg Tech A 2019 Feb 11. Epub 2019 Feb 11.

1 Department of General Surgery, Qilu Hospital, Shandong University, Jinan, China.

Background: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare pancreatic tumors. This study summarizes the clinicopathological characteristics and treatment outcomes of SPN patients through a 10-year single-center case series.

Materials And Methods: Medical records of patients diagnosed with SPNs and who underwent surgery between August 2007 and July 2017 at Qilu Hospital, Shandong University, were retrospectively analyzed. Read More

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http://dx.doi.org/10.1089/lap.2018.0704DOI Listing
February 2019
2 Reads

Evaluation of intracavitary carboplatin chemotherapy for treatment of pleural carcinomatosis in cats: a retrospective study of eight cases.

J Feline Med Surg 2019 Feb 5:1098612X19826401. Epub 2019 Feb 5.

1 ONCOVET, Veterinary Clinic of Referrals, Villeneuve d'Ascq, France.

Objectives: The aim of this study was to evaluate the benefit of intracavitary carboplatin chemotherapy in cats with malignant pleural effusion of epithelial origin.

Methods: The medical records of cats with a cytological diagnosis of neoplastic pleural effusion of epithelial origin were reviewed at three referral institutions between January 2013 and June 2018. Only cats treated with intracavitary carboplatin chemotherapy were enrolled. Read More

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http://dx.doi.org/10.1177/1098612X19826401DOI Listing
February 2019
1 Read

Mucin staining is of limited value in addition to basic immunohistochemical analyses in the diagnostics of non-small cell lung cancer.

Sci Rep 2019 Feb 4;9(1):1319. Epub 2019 Feb 4.

Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, SE-221 00, Lund, Sweden.

Accurate diagnosis of histological type is important for therapy selection in lung cancer. Immunohistochemical (IHC) and histochemical stains are often used to complement morphology for definite diagnosis and are incorporated in the WHO classification. Our main aim was to compare different mucin stains and assess their value in relation to common IHC analyses in lung cancer diagnostics. Read More

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http://dx.doi.org/10.1038/s41598-018-37722-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362145PMC
February 2019
2 Reads

Bronchial angiolipoma successfully treated by sleeve resection of the right bronchus intermedius: a case report.

BMC Surg 2019 Jan 31;19(1):13. Epub 2019 Jan 31.

Department of Thoracic Surgery, Iwate Prefectural Central Hospital, Ueda 1-4-1, Morioka, 020-0066, Japan.

Background: Angiolipoma is a rare, benign tumor that primarily develops in the limbs and trunk. The occurrence of angiolipoma in the lungs is extremely rare; to date, only two cases of primary bronchial angiolipoma have been reported. Here, we report a case of angiolipoma of the right bronchus intermedius that was successfully treated with sleeve resection and reconstructive surgery. Read More

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http://dx.doi.org/10.1186/s12893-019-0481-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357366PMC
January 2019

[Clinical significance of recombinant virus-specific detection for viable circulating tumor cells in lung cancer patients].

Zhonghua Jie He He Hu Xi Za Zhi 2019 Feb;42(2):101-105

Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

To investigate the clinical significance of recombinant virus-specific detection for detecting viable circulating tumor cell (CTC) in lung cancer patients. From June 2017 to August 2018, 63 lung cancer patients diagnosed by imaging and pathology at the Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital were recruited for this study, including 38 cases of adenocarcinoma, 13 squamous cell carcinoma, and 12 small cell carcinoma. The patients consisted of 36 males and 27 females, with an average age of (65±11) years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2019.02.005DOI Listing
February 2019
1 Read

[Treatment principle and surgical technique of pulmonary ground glass nodules].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):6-9

Department of thoracic surgery, Zhongshan hospital, Fudan university, Shanghai 200032, China.

Pulmonary ground glass nodule (GGN) is a term of radiological manifestation, which may be malignant or benign. GGN's imaging performance is diverse, and the management for pulmonary GGN remains controversial. Numerous clinical studies have clarified the safety of GGN follow-up and longer follow-up intervals, stricter surgical or biopsy indications are recommended. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.002DOI Listing
January 2019
1 Read

[Establishment and Verification of A Novel Predictive Model of Malignancy
for Non-solid Pulmonary Nodules].

Zhongguo Fei Ai Za Zhi 2019 Jan;22(1):26-33

Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.

Background: Mathematical predictive model is an effective method for preliminarily identifying the malignant pulmonary nodules. As the epidemiological trend of lung cancer changes, the detection rate of ground-glass-opacity (GGO) like early stage lung cancer is increasing rapidly, timely and proper clinical management can effectively improve the patients' prognosis. Our study aims to establish a novel predictive model of malignancy for non-solid pulmonary nodules, which would provide an objective evidence for invasive procedure and avoid unnecessary operation and the consequences. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.01.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348162PMC
January 2019
1 Read

[Preliminary Study on the Biological Markers for I-IIb Stage Non-small Cell Lung Cancer Based on a Serum-peptidomics].

Zhongguo Fei Ai Za Zhi 2019 Jan;22(1):20-25

Department of Thoracic Surgery, Third Central Hospital of Tianjin; Tianjin Institute of Hepatobiliary Disease; Tianjin Key Laboratory of Artificial Cell; Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin 300170, China.

Background: Non-small cell lung cancer (NSCLC) have the highest incidence of lung cancer which treatment principles are diagnosis and treatment as early as possible. Because of its insidious onset and lack of specific markers for early screening, most patients are at an advanced stage when diagnosed which results in a low 5-year survival rate and poor prognosis. Therefore Exploring a sensitive biomarker is the focus of current diagnosis and treatment of lung cancer. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.01.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348161PMC
January 2019

The prevalence of germline DICER1 pathogenic variation in cancer populations.

Mol Genet Genomic Med 2019 Jan 22:e555. Epub 2019 Jan 22.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland.

Background: The DICER1 syndrome is an autosomal dominant tumor-predisposition disorder associated with pleuropulmonary blastoma, a rare pediatric lung cancer. Somatic missense variation in "hotspot" codons in the RNaseIIIb domain (E1705, D1709, G1809, D1810, E1813) is observed in DICER1-associated tumors. Previously, we found the prevalence of germline pathogenic DICER1 variation in the general population is 1:10,600. Read More

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http://dx.doi.org/10.1002/mgg3.555DOI Listing
January 2019
12 Reads

[Leiomyoma of the esophagus : A further indication for robotic surgery?]

Chirurg 2019 Feb;90(2):125-130

Klinik für Allgemein-, Viszeral- und Thoraxchirurgie, Paracelsus Medizinische Privatuniversität Nürnberg, Prof.-Ernst-Nathan-Straße 1, 90419, Nürnberg, Deutschland.

Background: Leiomyomas of the esophagus are rare tumors but the most common benign lesion of the esophagus originating from smooth muscle cells. The symptoms are mainly determined by the size of the tumor and are caused by dysphagia and/or retrosternal pain. The majority of patients are however asymptomatic. Read More

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http://dx.doi.org/10.1007/s00104-019-0792-9DOI Listing
February 2019
1 Read

The need for bone biopsies in the diagnosis of new bone lesions in patients with a known primary malignancy: A comparative review of 117 biopsy cases.

J Bone Oncol 2019 Feb 18;14:100213. Epub 2018 Dec 18.

Department of Orthopedics, Zhongshan Hospital, Fudan University, 180# Fenglin Road, Xuhui district, Shanghai, China.

Objective: This study used a clinical dataset to investigate the proportion of the newly found bone lesions in malignant patients diagnosed by biopsy as being benign, malignant but unrelated to the primary malignancy, or bone metastases of the primary malignancy. The clinical factors that might affect the correlation between bone lesions and the primary malignancy were also analyzed. It is expected to obtain some information contributing to the clinical decision-making regarding the need for biopsy of these lesions from the research results. Read More

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http://dx.doi.org/10.1016/j.jbo.2018.100213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329701PMC
February 2019
1 Read

NETest liquid biopsy is Diagnostic of Lung Neuroendocrine Tumors and Identifies Progressive Disease.

Neuroendocrinology 2019 Jan 17. Epub 2019 Jan 17.


Background: There are no effective biomarkers for the management of bronchopulmonary carcinoids (BPC). We examined the utility of a neuroendocrine multigene transcript "liquid biopsy" (NETest) in bronchopulmonary carcinoids (BPC) for diagnosis and monitoring of disease status.

Aim: To independently validate the utility of the NETest in diagnosis and management of BPC in a multicenter, multinational blinded study. Read More

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http://dx.doi.org/10.1159/000497037DOI Listing
January 2019
7 Reads

KRAS mutations drive adenomatoid odontogenic tumor and are independent of clinicopathological features.

Mod Pathol 2019 Jan 14. Epub 2019 Jan 14.

Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Adenomatoid odontogenic tumor is a benign encapsulated epithelial odontogenic tumor that shows an indolent clinical behavior. We have reported in a few adenomatoid odontogenic tumors mutations in KRAS, which is a proto-oncogene frequently mutated in cancer such as lung, pancreas, and colorectal adenocarcinomas. We aimed to assess KRAS mutations in the hotspot codons 12, 13, and 61 in a large cohort of adenomatoid odontogenic tumors and to test the association of these mutations with clinical (age, site, tumor size, follicular/extrafollicular subtypes) and histopathological parameters. Read More

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http://www.nature.com/articles/s41379-018-0194-4
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http://dx.doi.org/10.1038/s41379-018-0194-4DOI Listing
January 2019
7 Reads

BAP1 Loss is a Useful Adjunct to Distinguish Malignant Mesothelioma Including the Adenomatoid-like Variant From Benign Adenomatoid Tumors.

Appl Immunohistochem Mol Morphol 2019 Jan 11. Epub 2019 Jan 11.

Institute of Pathology, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen.

Malignant mesothelioma (MM) can show areas closely mimicking reactive mesothelial proliferations or recapitulating benign adenomatoid tumors (ATs) making distinction on occasion impossible on morphologic ground alone, particularly in limited biopsy material. Recently, loss of BAP1 by immunohistochemistry (IHC) has been suggested as a potential marker for identifying MM, but data is still limited. We studied 264 MM cases (257 using tissue microarrays; 7 on conventional slides) and 42 genital ATs for BAP1 immunohistochemical expression. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000700DOI Listing
January 2019
2 Reads

Solitary Fibrous Tumor: Case Report of Intrapulmonary Location.

Case Rep Oncol Med 2018 2;2018:5745471. Epub 2018 Dec 2.

Department of Thoracic Surgery, Teaching Hospital Mohammed VI, University Cadi Ayyad, Morocco.

Solitary fibrous tumors are relatively rare neoplasms that commonly occur in the pleura, especially visceral pleura. However, an intrapulmonary site of this kind of tumors is even rarer. These tumors can be characterized by a heterogeneous evolution and have a benign or malignant behavior. Read More

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https://www.hindawi.com/journals/crionm/2018/5745471/
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http://dx.doi.org/10.1155/2018/5745471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304895PMC
December 2018
3 Reads

Expression of Prostate-Specific Membrane Antigen (PSMA) on Biopsies Is an Independent Risk Stratifier of Prostate Cancer Patients at Time of Initial Diagnosis.

Front Oncol 2018 20;8:623. Epub 2018 Dec 20.

Pathology of the University Hospital Schleswig-Holstein and Research Center Borstel, Leibniz Lung Center, Luebeck, Germany.

Stratifying prostate cancer (PCa) patients into risk groups at time of initial diagnosis enabling a risk-adapted disease management is still a major clinical challenge. Existing studies evaluating the prognostic potential of PSMA (prostate-specific membrane antigen) for PCa were performed on radical prostatectomy specimens (RPE), i.e. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2018.00623/
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http://dx.doi.org/10.3389/fonc.2018.00623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307416PMC
December 2018
2 Reads

Change of Circulating and Tissue-Based miR-20a in Human Cancers and Associated Prognostic Implication: A Systematic Review and Meta-Analysis.

Biomed Res Int 2018 25;2018:6124927. Epub 2018 Nov 25.

Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Orthopaedic Department, China-Japan Friendship Hospital, Chaoyang District, Beijing, China.

Background: Previous literatures have investigated the change of miR-20a expression level in the progression of multiple cancers and its influence on patients' survival outcome, but results of now-available evidence are inconsistent.

Objective: To elucidate the prognostic value of circulating and tissue-based miR-20a for patients with various cancers.

Methods: A systematic search and review of eligible publications were carried out in three electronic databases including the Cochrane Library, PubMed, and Embase, and the methodological quality of included studies was assessed according to Newcastle-Ottawa Scale (NOS). Read More

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http://dx.doi.org/10.1155/2018/6124927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286746PMC
November 2018
7 Reads

Clinical characteristics and treatment outcomes in six cases of malignant tenosynovial giant cell tumor: initial experience of molecularly targeted therapy.

BMC Cancer 2018 Dec 29;18(1):1296. Epub 2018 Dec 29.

Ludwig Center at Dana-Farber/Harvard and Center for Sarcoma and Bone Oncology, Department of Medical Oncology, Harvard Medical School, Boston, MA, USA.

Background: Although tenosynovial giant cell tumor (TGCT) is classified as a benign tumor, it may undergo malignant transformation and metastasize in extremely rare occasions. High aberrant expression of CSF1 has been implicated in the development of TGCT and recent studies have shown promising activity of several CSF1R inhibitors against benign diffuse-type TGCT; however, little is known about their effects in malignant TGCT.

Case Presentation: Information from six consenting patients (3 men, 3 women) with malignant TGCT presenting to Dana-Farber Cancer Institute for initial or subsequent consultation was collected. Read More

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http://dx.doi.org/10.1186/s12885-018-5188-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311045PMC
December 2018

Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart.

Exp Oncol 2018 12;40(4):336-342

Amosov National Institute of Cardiovascular Surgery, Kyiv 02000, Ukraine.

Background: Tumors of the heart are uncommon and usually benign (in 93% cases myxomas are observed). More often secondary, metastatic tumors are detected in the heart, as a rule, at pronounced progression of the malignant neoplasm with multiple lesions of other internal organs (lung, pleura, liver, etc.). Read More

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December 2018
1 Read

Folate-receptor-positive circulating tumor cells as an efficacious biomarker for the diagnosis of small pulmonary nodules.

J Cancer Res Ther 2018 ;14(7):1620-1626

Department of Thoracic Surgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.

Objective: The objective of this study is to investigate the clinical significance of folate-receptor-positive circulating tumor cells (FR+CTC) for the diagnosis of lung cancer, especially in early-stage patients.

Materials And Methods: A total of 72 lung cancer patients, including 31 with stage I diseases and two with stage 0 diseases, were enrolled in this study. Twenty-four patients with benign lung diseases and two healthy volunteers served as the control group. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_905_17DOI Listing
February 2019

Diagnostic Yield of Combined Pulmonary Cryobiopsies and Electromagnetic Navigation in Small Pulmonary Nodules.

Pulm Med 2018 15;2018:6032974. Epub 2018 Nov 15.

Department of Pneumology, Hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium.

Background: An increasing number of pulmonary nodules of unknown nature are detected as a result of screening by CT in high lung cancer risk patients.

Objectives: The purposes of this study were to assess the diagnostic yield of electromagnetic navigation bronchoscopy (ENB) combined with transbronchial lung cryobiopsy (TBLC) and to compare it with standard transbronchial biopsy (TBB) in pulmonary nodules of less than 2 cm in diameter.

Methods: We prospectively included 32 patients (18 men and 14 women, mean age 68 ± 9 years) with nodules of less than 2 cm in diameter and no metastasis at FDG PET-CT. Read More

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https://www.hindawi.com/journals/pm/2018/6032974/
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http://dx.doi.org/10.1155/2018/6032974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276421PMC
January 2019
1 Read

Multiple cavernous hemangiomas of the lung and liver mimicking metastasis: A case report and literature review.

Medicine (Baltimore) 2018 Dec;97(51):e13509

Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University.

Rationale: Cavernous hemangiomas are benign vascular malformations that usually involve the skin, subcutaneous tissue, and liver. Described herein was multiple masses in the lung and liver mimicking metastasis, which was proved to be cavernous hemangiomas histologically.

Patient Concerns: A 78-year-old man with complaint of dizziness for 3 days was referred to the local hospital for medical attention. Read More

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http://dx.doi.org/10.1097/MD.0000000000013509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319980PMC
December 2018
1 Read
5.723 Impact Factor

Immune Checkpoint Inhibitors in Pediatric Solid Tumors: Status in 2018.

Ochsner J 2018 ;18(4):370-376

Division of Bone Marrow Transplant and Benign Hematology, University of Kentucky, Lexington, KY.

Background: Checkpoint inhibitors have transformed the treatment of cancer in adults. This class of drugs has demonstrated encouraging results in various malignancies such as metastatic melanoma, bladder cancer, renal cancer, and non-small cell lung carcinoma. However, researchers have only begun investigating the effectiveness and tolerability of checkpoint inhibitors in pediatric patients. Read More

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http://www.ochsnerjournal.org/lookup/doi/10.31486/toj.18.005
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http://dx.doi.org/10.31486/toj.18.0055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292483PMC
January 2018
11 Reads

A Rare Case of Pulmonary Mucoepidermoid Carcinoma in an 81-Year-Old Male.

Am J Case Rep 2018 Dec 17;19:1499-1502. Epub 2018 Dec 17.

Department of Internal Medicine, Presence St Francis Hospital, Evanston, IL, USA.

BACKGROUND Lung mucoepidermoid carcinoma is a form of non-small cell lung carcinoma that originates from the submucosal glands of the tracheobronchial tree; it is rare and causes 0.1% to 0.2% of lung malignancies. Read More

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https://www.amjcaserep.com/abstract/index/idArt/911624
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http://dx.doi.org/10.12659/AJCR.911624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320553PMC
December 2018
8 Reads

[Mimics of lung cancer].

Radiologe 2019 Jan;59(1):57-70

Institut für Röntgendiagnostik, Otto-Wagner-Spital, Baumgartner Höhe 1, 1140, Wien, Österreich.

Lung cancer is a histologically, immunologically and therefore morphologically and functionally very heterogeneous group of neoplasms with the highest cancer mortality worldwide. Therefore, the range of diseases mimicking lung cancer is also very broad and includes congenital, infectious and inflammatory changes as well as other benign space-occupying lesions and other primary and secondary pulmonary neoplasms. The difficulty in radiology lies in the ability to diagnose lung cancer with a high degree of certainty. Read More

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http://dx.doi.org/10.1007/s00117-018-0476-3DOI Listing
January 2019

Primary pulmonary meningioma: A rare case report of aspiration cytological features and immunohistochemical assessment.

Diagn Cytopathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.

Ectopic meningioma is a generally rare type of benign tumor that very rarely occurs in the lung. Here, we report the cytological findings of a primary pulmonary meningioma with a particular focus on immunohistochemical (IHC) assessment. A healthy 60-year-old woman visited our hospital with an asymptomatic nodule in the right lower lung lobe. Read More

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http://dx.doi.org/10.1002/dc.24126DOI Listing
December 2018

Coexistence of secondary chondrosarcoma and lung carcinoma metastasis in the humerus of a patient with Ollier's disease: A case report.

Acta Orthop Traumatol Turc 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Istituto Ortopedico Rizzoli, Bologna, Italy.

Tumor-to-tumor metastasis in the same bone is an extremely rare condition. Limited number of case reports exists for coincidence of benign and malign neoplasms but none for malignant to malignant metastasis. Occurrence of several individual malignancies in the same patient may eventually cause such coexistences. Read More

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http://dx.doi.org/10.1016/j.aott.2018.10.008DOI Listing
December 2018
3 Reads

Histological Subtypes and Clinical Behavior Evaluation of Salivary Gland Tumors.

Acta Med Port 2018 Nov 30;31(11):641-647. Epub 2018 Nov 30.

Department of Pathology. Centro Hospitalar São João. Porto. Unit of Pathology and Oncology. Department of Pathology. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.

Introduction: Salivary gland tumors include a wide spectrum of histological subtypes and clinical behavior, which we aim to evaluate.

Material And Methods: We performed a retrospective study of all salivary gland tumors diagnosed and treated at the Centro Hospitalar São João, Porto, between 2005 and 2015. Histological re- evaluation was performed in all cases and patient files were reviewed and both clinical and follow-up data were collected. Read More

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http://dx.doi.org/10.20344/amp.9023DOI Listing
November 2018
17 Reads

Vitamin D and overall cancer risk and cancer mortality: a Mendelian randomization study.

Hum Mol Genet 2018 Dec;27(24):4315-4322

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

There is considerable debate regarding the role that 25-hydroxyvitamin D [25(OH)D] concentrations play in cancer risk or mortality, with earlier studies drawing mixed conclusions. Using data from the UK Biobank (UKB), we evaluate whether genetically predicted 25(OH)D concentrations are associated with overall cancer susceptibility and cancer mortality using five 25(OH)D genetic markers. Data comprised 438 870 white British UKB participants aged 37-73, including 46 155 cancer cases and 6998 cancer-specific deaths. Read More

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http://dx.doi.org/10.1093/hmg/ddy307DOI Listing
December 2018
2 Reads

Exosomal MicroRNA Expression Profiling in Patients with Lung Adenocarcinoma-associated Malignant Pleural Effusion.

Anticancer Res 2018 Dec;38(12):6707-6714

The Department of Respiratory Medicine, The University of Tokyo Hospital, Tokyo, Japan.

Background/aim: Cytological analysis for diagnosing malignant pleural effusion associated with lung adenocarcinoma (Ad-MPE) shows limited sensitivity and novel diagnostic biomarkers are needed. The aim of this study was to evaluate the profile of four microRNAs (miRNAs) in exosomes in Ad-MPE and benign (non-neoplastic) pleural effusion (BPE).

Materials And Methods: A total of 56 pleural effusion samples from patients with lung adenocarcinoma and benign diseases were collected. Read More

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http://dx.doi.org/10.21873/anticanres.13039DOI Listing
December 2018
1 Read

FOXP3 and CD25 double staining antibody cocktails identify regulatory T cells in different types of tumor tissues using tissue microarrays.

Ann Diagn Pathol 2019 Feb 22;38:67-70. Epub 2018 Nov 22.

Department of Pathology, University of Texas McGovern Medical School, Houston, TX, 77030, United States of America. Electronic address:

Regulatory T cells (Tregs) are CD4+ T cells that express CD25 and transcription factor Forkhead box P3 (FOXP3), and Tregs play a central role in regulation of tumor immunity. FOXP3 immunohistochemistry has been widely used to study Tregs in paraffin embedded tissue, and flow cytometry using fresh tissue has been used to identify FOXP3+/CD25+ double positive Tregs. In our study, we validated the FOXP3/CD25 double staining antibody cocktails for detecting Tregs in paraffin-embedded tissue. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183034
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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.005DOI Listing
February 2019
8 Reads

[Comparative analysis of computed tomography texture features between pulmonary inflammatory nodules and lung cancer].

Zhonghua Zhong Liu Za Zhi 2018 Nov;40(11):847-850

Department of Radiology, Shanxi Dayi Hospital, Taiyuan 030032, China.

To investigate the value of computed tomography (CT) texture analysis in differential diagnosis of inflammatory and malignant pulmonary nodules. The image data of 54 patients with lung cancer and 36 patients with pulmonary inflammatory nodules were retrospectively collected in our hospital. All the patients received chest CT scan. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.11.010DOI Listing
November 2018
9 Reads

Evaluating Clinical Genome Sequence Analysis by Watson for Genomics.

Front Med (Lausanne) 2018 9;5:305. Epub 2018 Nov 9.

Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.

Oncologists increasingly rely on clinical genome sequencing to pursue effective, molecularly targeted therapies. This study assesses the validity and utility of the artificial intelligence Watson for Genomics (WfG) for analyzing clinical sequencing results. This study identified patients with solid tumors who participated in in-house genome sequencing projects at a single cancer specialty hospital between April 2013 and October 2016. Read More

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https://www.frontiersin.org/article/10.3389/fmed.2018.00305/
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http://dx.doi.org/10.3389/fmed.2018.00305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237914PMC
November 2018
10 Reads

A 20 Year Experience with Resection of Primary Cardiac Tumors and Metastatic Tumors of the Heart.

Ann Thorac Surg 2018 Nov 21. Epub 2018 Nov 21.

Weill Cornell Medicine, 525 E 68(th) St, Suite M404, New York, NY 10065. Department of Cardiothoracic Surgery.

Background: Cardiac tumors are uncommon, occurring in less than one percent of the population, and are comprised of numerous tumor types. Management of certain tumors types such as sarcoma have evolved and improved in the recent era. We evaluate the outcomes of patients who underwent resection of benign or malignant cardiac tumors with a focused review of cardiac sarcomas. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.10.023DOI Listing
November 2018
7 Reads

Adrenal cavernous hemangioma: a case report.

BMC Surg 2018 Nov 20;18(1):103. Epub 2018 Nov 20.

Department of Clinical and Experimental Medicine, Unit of General Surgery 2, University of Sassari, Sassari, Italy.

Background: Adrenal cavernous hemangiomas are very rare benign tumors that usually present as incidental findings on abdominal imaging. Preoperative differential diagnosis from other benign or malignant adrenal neoplasms may be challenging.

Case Presentation: A 70-year old man was referred for an 8-cm abdominal mass incidentally discovered on a contrast-enhanced computed tomography (CT) performed to investigate a pulmonary nodule. Read More

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http://dx.doi.org/10.1186/s12893-018-0429-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247755PMC
November 2018
11 Reads

Malignant phyllodes tumor with metastases to lung, adrenal and brain: A rare case report.

Ann Med Surg (Lond) 2018 Dec 2;36:113-117. Epub 2018 Nov 2.

Department of Dermatology, Tribhuvan University Teaching Hospital, Nepal.

Background: Phyllodes tumors are spectrum of tumors ranging from benign to malignant. Malignant spectrum pose a management challenge for clinicians due to high risks of recurrence and metastasis. Malignant phyllodes tumor with brain, lung and adrenal metastases at the same time is rare. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20490801183023
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http://dx.doi.org/10.1016/j.amsu.2018.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230968PMC
December 2018
19 Reads

[Incidence of Lower Limb Deep Venous Thrombosis and Coagulation Status 
in Severe Patients after Thoracic Surgery].

Zhongguo Fei Ai Za Zhi 2018 Nov;21(11):864-867

Department of Interventional Radiography, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Background: The aim of this study was to analyze the incidence of lower limb deep venous thrombosis (DVT) and the corresponding coagulation status in severe patients after thoracic surgery.

Methods: Severe patients after thoracic surgery who received mechanical prophylaxis of lower limb DVT between July 2016 and June 2018 were analysed retrospectively. Their general information, disease species, surgical treatment, and coagulation index were reviewed. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2018.11.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247009PMC
November 2018
7 Reads

Increased Expression of GARP in Papillary Thyroid Carcinoma.

Endocr Pathol 2018 Nov 16. Epub 2018 Nov 16.

Department of Anatomy, College of Basic Medical Sciences of Jinzhou Medical University, Jinzhou, 121001, Liaoning, China.

Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. Read More

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http://link.springer.com/10.1007/s12022-018-9557-0
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http://dx.doi.org/10.1007/s12022-018-9557-0DOI Listing
November 2018
8 Reads

Coexistence of neurofibromatosis type 1 with multiple malignant neoplasia.

Neuro Endocrinol Lett 2018 Sep;39(3):149-155

Clinical Department of Endocrinology, Jagiellonian University in Krakow, Poland.

Neurofibromatosis type 1 (NF1, von Recklinghausen disease) is inherited in autosomal dominant way genetic disorder, with an incidence at birth 1:3000. It is one of the most common congenital disorders. It is characterized by café-au-lait spots, neurofibromas, and less common MPTST and gliomas of the optic nerve. Read More

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September 2018
12 Reads

Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma.

Sci Transl Med 2018 Nov;10(467)

Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

The diagnostic definition of indeterminate lung nodules as malignant or benign poses a major challenge for clinicians. We discovered a potential marker, the sodium-dependent glucose transporter 2 (SGLT2), whose activity identified metabolically active lung premalignancy and early-stage lung adenocarcinoma (LADC). We found that SGLT2 is expressed early in lung tumorigenesis and is found specifically in premalignant lesions and well-differentiated adenocarcinomas. Read More

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http://dx.doi.org/10.1126/scitranslmed.aat5933DOI Listing
November 2018
14 Reads

Tumor-Derived Autoantibodies Identify Malignant Pulmonary Nodules.

Am J Respir Crit Care Med 2018 Nov 13. Epub 2018 Nov 13.

Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, Washington, United States.

Rationale: Screening for non-small cell lung cancer is associated with earlier diagnosis and reduced mortality but also increased harm due to invasive follow up of benign pulmonary nodules. Lung tumorigenesis activates the immune system, components of which could serve as tumor specific biomarkers.

Objectives: To profile tumor-derived autoantibodies as peripheral biomarkers of malignant pulmonary nodules. Read More

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https://www.atsjournals.org/toc/ajrccm/0/ja
Web Search
https://www.atsjournals.org/doi/10.1164/rccm.201804-0628OC
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http://dx.doi.org/10.1164/rccm.201804-0628OCDOI Listing
November 2018
8 Reads

Clinicopathologic features of anaplastic myxopapillary ependymomas.

Brain Pathol 2019 01;29(1):75-84

Department of Pathology, University of California, San Francisco, CA.

Myxopapillary ependymomas (MPE) are considered benign (World Health Organization (WHO) grade I) neoplasms with favorable prognosis. However, malignant behavior occurs in a small subset. To our knowledge, only five anaplastic MPEs have been reported without consensus on diagnostic criteria. Read More

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http://doi.wiley.com/10.1111/bpa.12673
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http://dx.doi.org/10.1111/bpa.12673DOI Listing
January 2019
10 Reads
3.840 Impact Factor

The Role of CXCL12 Axis in Lung Metastasis of Colorectal Cancer.

J Cancer 2018 10;9(21):3898-3903. Epub 2018 Oct 10.

Department of Gastroenterological Surgery, West China Hospital, Sichuan University, Chengdu, 610041.

This study aimed to explore the mechanism of lung metastases of colorectal cancer. The expression of CXCR4, CXCR7, and CXCL12 in colorectal cancer and lung metastases was analyzed by the immunohistochemical (IHC) method. Further, the study aimed at getting new insights into the role of CXCL12 in lung metastasis. Read More

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http://dx.doi.org/10.7150/jca.26383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218771PMC
October 2018
1 Read

A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer.

PLoS One 2018 8;13(11):e0206950. Epub 2018 Nov 8.

Department of Radiology, Duke University Medical Center, Durham, North Carolina, United States of America.

Computed tomography (CT) is the standard imaging test used for the screening and assessment of suspected lung cancer, but distinguishing malignant from benign nodules by CT is an ongoing challenge. Consequently, a large number of avoidable invasive procedures are performed on patients with benign nodules in order to exclude malignancy. Improving cancer discrimination by non-invasive imaging could reduce the need for invasive diagnostics. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206950PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224087PMC
November 2018
8 Reads

Giant solitary fibrous tumor of the pleura.

J Surg Case Rep 2018 Nov 1;2018(11):rjy270. Epub 2018 Nov 1.

Department of Thoracic Surgery, Valiasr Hospital, Tehran University of Medical Science, Tehran, Iran.

Introduction: Solitary fibrous tumors of the pleura (SFTP) are rare mesenchymal tumors representing <5% of all tumors of the pleura. Literature reveals only two case series and a few solitary reports.

Case Report: A 68-year-old male presented to our hospital after experiencing exertional dyspnea. Read More

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http://dx.doi.org/10.1093/jscr/rjy270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210664PMC
November 2018
2 Reads

Torsion Ovary, an Unusual Presentation of Carcinoma Appendix Detected in Whole-Body F-18 2-Fluoro 2-deoxy Glucose Positron Emission Tomography/Computed Tomography Scan.

Indian J Nucl Med 2018 Oct-Dec;33(4):331-333

Department of Nuclear Medicine, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.

Torsion ovary is one of the common emergencies in gynecology requiring surgery. Torsion ovary is generally caused by cystic lesions of ovary and benign tumors. Malignant tumors rarely present as torsion ovary. Read More

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http://www.ijnm.in/text.asp?2018/33/4/331/242954
Publisher Site
http://dx.doi.org/10.4103/ijnm.IJNM_97_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194758PMC
November 2018
11 Reads

68Ga-PSMA PET/CT in prostate cancer patients - patterns of disease, benign findings and pitfalls.

Cancer Imaging 2018 Nov 1;18(1):39. Epub 2018 Nov 1.

Department of Medical Biophysics and Nuclear Medicine, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel.

Background: 68Ga-PSMA PET/CT has an important role in assessment of prostate cancer patients with biochemical recurrence and is evolving in staging high- and intermediate risk disease. The aim of present study was to describe the metastatic patterns and frequency of involved sites of prostate cancer and to assess the incidence of benign Ga68-PSMA avid PET/CT findings in a large patient population.

Methods: 68Ga-PSMA PET/CT studies performed in two tertiary medical centers over a period of 24 months were retrospectively reviewed. Read More

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https://cancerimagingjournal.biomedcentral.com/articles/10.1
Publisher Site
http://dx.doi.org/10.1186/s40644-018-0175-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211573PMC
November 2018
3 Reads