9,770 results match your criteria Benign Lung Tumors


Multiple Pulmonary Metastases of Recurrent Giant Cell Tumor of Bone with Expression of VEGFR-2 Successfully Controlled by Denosumab and Apatinib: A Case Report and Literature Review.

Cancer Manag Res 2021 3;13:4447-4454. Epub 2021 Jun 3.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.

Giant cell tumor of bone (GCTB) is a rare, benign, but locally aggressive bone tumor. It has a high tendency for local recurrence, which may increase the incidence of lung metastasis. Currently, an optimal treatment strategy has not been established because of the rarity of pulmonary metastatic GCTB. Read More

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High Diagnostic and Prognostic Value of miRNAs Compared with the Carcinoembryonic Antigen as a Traditional Tumor Marker.

Anticancer Agents Med Chem 2021 Jun 7. Epub 2021 Jun 7.

Bioinformatics Research Group, Mashhad University of Medical Sciences, Mashhad, Iran.

A significant challenge in cancer detection and treatment is early diagnosis and accurate prognosis of the disease that enables effective therapies and interventions to improve the patient's condition. Up to now, many parts of research have tended to focus on the carcinoembryonic antigen (CEA) to detect cancers and estimate the survival rates of patients with multiple cancer types, including colorectal, breast, non-small cell lung, and pancreas cancer. Limited sensitivity and specificity of this traditional tumor marker make it an inappropriate biomarker to diagnose cancer, especially in the early stages, while several lines of research have introduced miRNAs as reliable indicators of tumor initiation, development, and therapy response. Read More

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Evaluation of OTL38-Generated Tumor-to-Background Ratio in Intraoperative Molecular Imaging-Guided Lung Cancer Resections.

Mol Imaging Biol 2021 Jun 8. Epub 2021 Jun 8.

Department of Thoracic Surgery, University of Pennsylvania Perelman School of Medicine, 3400 Spruce Street, 6 White Building, Philadelphia, PA, 19104, USA.

Introduction: Cancer surgery has multiple challenges including localizing small lesions, ensuring negative margins, and identifying synchronous cancers. One of the tools proposed to address these issues is intraoperative molecular imaging (IMI). An important consideration in IMI is the quantification of the tumor fluorescence during the procedure and using that data to add clinical value. Read More

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Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature.

Medicina (Kaunas) 2021 May 23;57(6). Epub 2021 May 23.

Thoracic Surgery Unit, Department of Organ Transplantation and Emergency, University Hospital of Bari, 70124 Bari, Italy.

Pulmonary sclerosing pneumocytoma is a rare benign pulmonary tumor of primitive epithelial origin. Because of the unspecific radiological features mimicking malignancies and its histological heterogeneity, the differential diagnosis with adenocarcinoma and carcinoid tumors is still challenging. We report our experience of two cases of sclerosing pneumocytoma, as well as a review of the literature. Read More

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Laparoscopic adrenalectomy for suspected adrenal mass in lung cancer: ganglioneuroma.

Tumori 2021 Jun 1:3008916211020080. Epub 2021 Jun 1.

Medicana Health Group, Bursa Medicana Hospital, Bursa, Turkey.

Background: Adrenalectomy is the gold standard for the treatment of primary adrenal ganglioneuroma. Preoperative differential diagnosis of ganglioneuroma is difficult and histopathologic examination is required to confirm the diagnosis.

Patient: A 61-year-old woman, who was followed and treated by the medical oncology department because of lung carcinoma pathology squamous cell T4N0Mx, presented to our clinic due to a 15×8-mm nodule with a calculated relative wash-out rate of 40% in the right adrenal gland lateral edge, which was observed on computed tomography examination. Read More

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Incidental Lung Nodules on Cross-sectional Imaging: Current Reporting and Management.

Radiol Clin North Am 2021 Jul;59(4):535-549

Department of Radiology, NYU Grossman School of Medicine, NYU Langone Health, Center for Biomedical Imaging, 660 First Avenue, New York, NY 10016, USA.

Pulmonary nodules are the most common incidental finding in the chest, particularly on computed tomographs that include a portion or all of the chest, and may be encountered more frequently with increasing utilization of cross-sectional imaging. Established guidelines address the reporting and management of incidental pulmonary nodules, both solid and subsolid, synthesizing nodule and patient features to distinguish benign nodules from those of potential clinical consequence. Standard nodule assessment is essential for the accurate reporting of nodule size, attenuation, and morphology, all features with varying risk implications and thus management recommendations. Read More

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Increased 68Ga-FAPI Uptake in Neurofibromatosis in a Patient With Pleomorphic Rhabdomyosarcoma.

Clin Nucl Med 2021 May 26. Epub 2021 May 26.

From the Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University; and Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province; and Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan, China.

Abstract: A 48-year-old man presented with a painless enlarging mass on his right thigh for 2 months. He had a history of neurofibromatosis. MRI showed a mass in his right thigh. Read More

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Contractility, focal adhesion orientation, and stress fiber orientation drive cancer cell polarity and migration along wavy ECM substrates.

Proc Natl Acad Sci U S A 2021 Jun;118(22)

Cell and Developmental Biology Center, National Heart Lung and Blood Institute, NIH, Bethesda, MD 20892;

Contact guidance is a powerful topographical cue that induces persistent directional cell migration. Healthy tissue stroma is characterized by a meshwork of wavy extracellular matrix (ECM) fiber bundles, whereas metastasis-prone stroma exhibit less wavy, more linear fibers. The latter topography correlates with poor prognosis, whereas more wavy bundles correlate with benign tumors. Read More

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[Diagnosis and treatment of benign lung tumors].

Authors:
S A Plaksin

Khirurgiia (Mosk) 2021 (6):106-111

Vagner Perm State Medical University, Perm, Russia.

Benign lung tumors account 2-12% of all lung neoplasms. The classification of lung tumors, adopted by the World Health Organization in 2015, is reported with a detailed indication of all changes based on immunohistochemical and genetic studies. Diagnosis with computed tomography, dynamic and perfusion computed tomography, virtual bronchoscopy and positron emission tomography is described. Read More

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Surgery in congenital lung malformations: the evolution from thoracotomy to VATS, 10-year experience in a single center.

J Cardiothorac Surg 2021 May 17;16(1):131. Epub 2021 May 17.

Department of Thoracic Surgery, University of Health Sciences Dr Suat Seren Chest Diseases and Chest Surgery Training and Research Hospital Izmir, 35110, Yenişehir, Gaziler Street, 331, Izmir, Turkey.

Background: Congenital lung malformation is an umbrella term and consist of various kind of parenchymal and mediastinal pathologies. Surgical resection is often required for diagnosis and curative treatment. We aimed to review our experience in surgical treatment for congenital lung disease and present the role of minimally invasive surgery. Read More

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Expression of Myoglobin in Normal and Cancer Brain Tissues: Correlation With Hypoxia Markers.

Front Oncol 2021 30;11:590771. Epub 2021 Apr 30.

Center for Aging and Associated Diseases, Zewail City of Science, Technology and Innovation, 6th of October, Egypt.

Background: Myoglobin (MB) is increasingly recognized as a key player in cancer growth and metastasis. Low oxygen tensions, commonly associated with highly aggressive and recurrent cancers, have been shown to regulate its expression in several cancers such as lung, neck, prostate and breast cancer. However, it is not yet known whether it contributes to the growth and spread of brain cancers especially Glioblastoma multiforme (GBM). Read More

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Differential Ca responses and store operated Ca entry in primary cells from human brain tumors.

Biochim Biophys Acta Mol Cell Res 2021 Jul 14;1868(8):119060. Epub 2021 May 14.

Unit of Excellence Institute of Biology and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), Valladolid, Spain; Department of Biochemistry and Molecular Biology and Physiology, School of Medicine, University of Valladolid. Valladolid, Spain.

Brain tumors comprise a large series of tumor cancer from benign to highly malignant gliomas and metastases from primary tumors outside the brain. Intracellular Ca homeostasis is involved in a large series of cell functions including cell proliferation, migration, and cell death. Store-operated Ca entry (SOCE), the most important Ca entry pathway in non-excitable cells, is involved in cell proliferation and migration and enhanced in tumor cells from breast cancer, colon cancer and cell lines derived from glioblastoma but there are almost no studies in human primary glioblastoma cells or other brain tumors. Read More

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Can MRI differentiate surrounding vertebral invasion from reactive inflammatory changes in superior sulcus tumor?

Eur Radiol 2021 May 15. Epub 2021 May 15.

Department of Radiology, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, 94800, Paris, France.

Objectives: Vertebral invasion is a key prognostic factor and a critical aspect of surgical planning for superior sulcus tumors. This study aims to further evaluate MRI features of vertebral invasion in order to distinguish it from reactive inflammatory changes.

Methods: Between 2000 and 2016, a retrospective study was performed at a single institution. Read More

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Two-stage S sleeve resection of the right lower lobe and S and S segmentectomy of the left upper lobe: a case report.

Ann Transl Med 2021 Apr;9(8):723

Department of Thoracic Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China.

Synchronous multiple nodules in the lungs, such as peripheral ground-glass opacities (GGOs) and solid small nodules, are common, but only lesions suspected of being malignant should be surgically removed. The surgical strategy is anatomical sub-lobectomy in early stage of non-small cell lung cancer synchronously or asynchronously to decrease the impact of lung resection on the lung function. Here, we report a case of a 56-year-old man, who was a pack-a-day smoker, with endobronchial hamartomas the medial basal bronchus (B7). Read More

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Differentiating malignant and benign necrotic lung lesions using kVp-switching dual-energy spectral computed tomography.

BMC Med Imaging 2021 May 13;21(1):81. Epub 2021 May 13.

Department of Radiology, University of Chinese Academy of Sciences Chongqing Renji Hospital (Fifth People's Hospital of Chongqing), No. 24 Renji Road, Nan'an District, Chongqing, China.

Background: Necrotic pulmonary lesions manifest as relatively low-density internally on contrast-enhanced computed tomography (CT). However, using CT to differentiate malignant and benign necrotic pulmonary lesions is challenging, as these lesions have similar peripheral enhancement. With the introduction of dual-energy spectral CT (DESCT), more quantitative parameters can be obtained and the ability to differentiate material compositions has been highly promoted. Read More

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Metastatic Hepatic Epitheloid Hemangioendothelioma in a Young Male: A Rare Presentation.

Gastrointest Tumors 2021 Apr 18;8(2):58-62. Epub 2021 Feb 18.

Department of General Surgery, AIIMS, Bhopal, Madhya Pradesh, India.

Hepatic EHE (epithelioid hemangioendothelioma) is an uncommon entity of vascular origin and a low-grade malignant tumor. Primary hepatic EHE is rare. These tumors can be multifocal at presentation like in the soft tissues, bones, brain, liver, and small intestine. Read More

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[A Long‒Term Survival Case of Advanced Rectal Cancer with Liver and Lung, Para‒Aortic Lymph Nodes Metastasis That Responded to Multidisciplinary Therapy].

Gan To Kagaku Ryoho 2021 Apr;48(4):566-568

Dept. of Surgery, Yokohama City University.

The patient was a 59‒year‒old woman. In 2005, she underwent low anterior resection plus D2 dissection for rectal cancer (pT4aN2aM0, pStage Ⅲb). In 2007, she underwent hepatic S8 subsegment resection for liver metastasis. Read More

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[Primary Pulmonary Paraganglioma:Report of a Case].

Kyobu Geka 2021 Feb;74(2):160-163

Department of General Thoracic Surgery, National Obihiro Hospital, Obihiro, Japan.

A 60-year-old woman with a lung tumor was admitted to our hospital for surgical treatment. Chest computed tomography (CT) showed a 23×21×20 mm nodule in the right lower lobe. Although the lung nodule was thought to be benign due to CT image findings, its size was apparently larger than that of CT image at four years ago. Read More

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February 2021

Optimal margins for early stage peripheral lung adenocarcinoma resection.

BMC Cancer 2021 May 11;21(1):533. Epub 2021 May 11.

Wuxi Lung Transplant Center, Wuxi People's Hospital Affiliated to Nanjing Medical University, 299 QingYang Road, Wuxi, 214023, China.

Background: A pathologically confirmed negative margin is required when performing sublobar resection in patients with early stage peripheral lung adenocarcinoma. However, the optimal margin distance to ensure complete tumor resection while preserving healthy lung tissue remains unknown. We aimed to establish a reliable distance range for negative margins. Read More

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Circulating tumor cells with epithelial-mesenchymal transition markers as potential biomarkers for the diagnosis of lung cancer.

World J Clin Cases 2021 Apr;9(12):2721-2730

Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing 400042, China.

Background: Circulating tumor cells (CTCs) can be clustered into three subtypes according to epithelial-mesenchymal transition (EMT) markers: CTCs with epithelial markers (E-CTCs), CTCs with mesenchymal markers (M-CTCs), and CTCs with both markers (E&M-CTCs). CTC detection has clinical implications in the diagnosis of lung cancer (LC).

Aim: To clarify the diagnostic value of CTCs categorized by EMT markers in LC. Read More

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Utility of liquid-based cytology on residual needle rinses collected from core needle biopsy for lung nodule diagnosis.

Cancer Med 2021 May 7. Epub 2021 May 7.

Department of Anorectal Surgery, The First Affiliated Hospital of University of South China, Hengyang, China.

Background: Core needle biopsy (CNB) has become the most common tissue sampling modality for pathological diagnosis of peripheral lung nodules. However, approximately 10% of pulmonary CNB specimens cannot be unambiguously diagnosed, even with auxiliary techniques. This retrospective study investigated the diagnostic value of liquid-based cytology on residual pulmonary CNB material collected from needle rinses. Read More

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Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial.

Eur Respir J 2021 May 6. Epub 2021 May 6.

Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China.

Background: Guidelines recommend endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) as an initial investigation technique for mediastinal nodal staging in lung cancer. However, EBUS-TBNA can be limited by the inadequacy of intact tissues, which might restrict its diagnostic yield in mediastinal lesions of certain etiologies. We have previously shown that EBUS-guided transbronchial mediastinal cryobiopsy can provide intact samples with greater volume. Read More

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Comparison of Targeted and Untargeted Approaches in Breath Analysis for the Discrimination of Lung Cancer from Benign Pulmonary Diseases and Healthy Persons.

Molecules 2021 Apr 29;26(9). Epub 2021 Apr 29.

Department of Hygiene and Epidemiology, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, 22 Papakyriazi Street, 41222 Larissa, Greece.

The aim of the present study was to compare the efficiency of targeted and untargeted breath analysis in the discrimination of lung cancer (Ca+) patients from healthy people (HC) and patients with benign pulmonary diseases (Ca-). Exhaled breath samples from 49 Ca+ patients, 36 Ca- patients and 52 healthy controls (HC) were analyzed by an SPME-GC-MS method. Untargeted treatment of the acquired data was performed with the use of the web-based platform XCMS Online combined with manual reprocessing of raw chromatographic data. Read More

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Expression of Oncogene in Benign, Malignant and Borderline Melanocytic Tumors-Unmasking the Wolf in Sheep's Clothing?

Cancers (Basel) 2021 Apr 1;13(7). Epub 2021 Apr 1.

Department of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, D-66421 Homburg, Germany.

oncogene located at chromosomal region 3q26 encodes for a transmembrane protein of the endoplasmic reticulum (ER) and is expressed at high levels in numerous human malignancies. overexpression has been associated with worse prognosis and high risk for lymphatic and distant metastases in head and neck cancer, cervical cancer, hepatocellular cancer, and lung cancer. However, its role in the development and tumor biology of melanocytic lesions has not been investigated so far. Read More

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[Clinicopathological features of bronchiolar adenoma versus mixed squamous cell and glandular papilloma: a comparative analysis].

Zhonghua Bing Li Xue Za Zhi 2021 May;50(5):458-464

Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China.

To observe the clinicopathological features of bronchiolar adenoma (BA) and mixed squamous cell and glandular papilloma (MSGP). The relationship between them was also analyzed. Clinical data of eight patients with BA and four patients with MSGP diagnosed in China-Japan Friendship Hospital were collected from January 2018 to January 2020. Read More

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[Detection of circulating tumor cells with chromosomes 7 and 8 polysomy in non-small cell lung cancer and its correlation with epidermal growth factor receptor mutations in cancer tissue].

Zhonghua Bing Li Xue Za Zhi 2021 May;50(5):447-452

Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

To investigate the value of chromosomes 7 and 8 polysomy in circulating tumor cells (CTCs) for the diagnosis of non-small cell lung cancer, and the correlation of CTCs with clinical pathological characteristics and epidermal growth factor receptor (EGFR) mutations in cancer tissue. Fifty-seven patients with non-small cell lung cancer and 21 patients with benign lung diseases were enrolled at Beijing Chaoyang Hospital, Capital Medical University, Beijing, China from November 2017 to October 2020. Negative enrichment combined with immunofluorescence in situ hybridization (imFISH) was used to identify CTCs polysomy on chromosomes 7 and 8. Read More

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Benign Metastasizing Leiomyoma in the Heart of a 45-Year-Old Woman.

Tex Heart Inst J 2021 01;48(1)

Harrington Heart & Vascular Institute, Cardiovascular Medicine Department, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.

We report a rare case of benign metastasizing leiomyoma in the heart of a 45-year-old woman 2 years after a uterine leiomyoma had been discovered during hysterectomy. Computed tomograms at presentation showed a large mixed cystic mass in the pelvis and bilateral lung nodules suggestive of metastatic disease. A large cardiac mass, attached to the chordae of the tricuspid valve and later shown to be histopathologically consistent with uterine leiomyoma, was successfully resected through a right atriotomy. Read More

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January 2021

DNA Methylation Profiling Discriminates between Malignant Pleural Mesothelioma and Neoplastic or Reactive Histologic Mimics.

J Mol Diagn 2021 Apr 20. Epub 2021 Apr 20.

Department of Neuropathology, Institute of Pathology, University Hospital of Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

The diagnosis of malignant pleural mesothelioma (MPM) is challenging because of its potential overlap with other neoplasms or even with reactive conditions. Recently, DNA methylation analysis was reported as effective in the diagnosis of tumors. In the present study, this approach was tested for use in the diagnosis of MPM. Read More

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Interlobar Pulmonary Hamartoma With an Unusual Neighboring Lesion: A Case Report.

Cureus 2021 Mar 20;13(3):e14008. Epub 2021 Mar 20.

Internal Medicine, Salmaniya Medical Complex, Manama, BHR.

Pulmonary hamartomas are benign lung tumors. They are uncommon and represent a small percentage of all solitary lung lesions. Hamartomas are composed of an abnormal mixture of epithelial and mesenchymal elements. Read More

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Rare pulmonary tumors and carcinoma mimickers; experience from an interventional radiology unit with radiologic-pathologic correlation-A pictoral essay.

Curr Med Imaging 2021 Apr 19. Epub 2021 Apr 19.

Hacettepe University, School of Medicine, Department of Radiology Ankara, Turkey.

Background: Although imaging findings along with patients' clinical history may give clue for the etiology of a pulmonary lesion, the differentiation of benign pulmonary lesions from lung cancer could be challenging.

Objective: The aim of this review article was to increase the awareness of the carcinoma mimicking lung lesions.

Methods: This paper was designed to illustrate rare pulmonary tumors and carcinoma mimickers with emphasis on radiologic-pathologic correlation. Read More

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