214,086 results match your criteria Benign Lung Tumors


Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions.

Endocr Rev 2018 Dec 12. Epub 2018 Dec 12.

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA.

Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peri-transplant management of the islet transplant recipient have resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or sub-total pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate post-surgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality-of-life is substantially improved. Read More

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December 2018
1 Read

An unusual presentation of papillary thyroid carcinoma in a pediatric patient: A case report.

Ear Nose Throat J 2018 Dec;97(12):E7-E10

University of Arizona College of Medicine - Tucson, 1501 N. Campbell Ave., PO Box 245017, Tucson, AZ 85724, USA.

Cystic neck masses in the pediatric population are common but rarely concerning for malignancy. Given this typically benign nature, they are frequently managed conservatively. Here we present an unusual case of a waxing and waning cystic neck mass in a pediatric patient. Read More

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December 2018
2 Reads

68Ga-PSMA Uptake in Anal Fistula on PET/CT Scan.

Clin Nucl Med 2019 Jan;44(1):e54-e56

From the Departments of Nuclear Medicine and PET Centre, and.

Ga-prostate-specific membrane antigen (PSMA) PET/CT scan for primary staging discovered increased Ga-PSMA uptake in a known anal fistula in a recently diagnosed high-risk prostate cancer patient. The patient had an ongoing history of surgical revisions of complex fistulas in the perianal region, contributing to active inflammation and infection. Recently, reports have demonstrated increased Ga-PSMA uptake in different benign inflammatory conditions. Read More

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January 2019

ANALYSIS OF RISK FACTORS AND POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH CROHN'S DISEASE.

Arq Gastroenterol 2018 Jul-Sep;55(3):252-257

Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Departamento de Cirurgia e Ortopedia, Botucatu, SP, Brasil.

Background: The post-operative complications rate is greater in patients with Crohn's disease than in other abdominal surgeries due to other benign conditions. Prevention and management of such complications are important factors in the care of these patients.

Objective: The objectives of this research are to analyze the rate of postoperative complications and the major risk factors in patients with Crohn's disease. Read More

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February 2018

[Coxiella burnetii and Q fever in Brazil: a public health issue].

Cien Saude Colet 2018 Dec;23(12):4231-4239

Faculdade de Ciências Humanas, Econômicas e da Saúde de Araguaína, Instituto Tocantinense Presidente Antônio Carlos. Av. Filadélfia 568, Setor Oeste. 77816-540 Araguaína TO Brasil.

Q fever is a zoonosis that is broadly distributed worldwide, despite few reports associated with its occurrence in Brazil. Coxiella burnetii, namely the causative agent of Q fever is a gram-negative coccobacillus and an obligate intracellular bacterial parasite of the order of Legionellales. The microorganism is generally present in the urine and feces of infected animals and can be found in large quantities in placental membranes of at-term or aborted animals. Read More

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December 2018

Ultrasonographic diagnosis of benign masseter muscle hypertrophy: A case report.

J Cancer Res Ther 2018 Dec;14(Supplement):S1237-S1240

Department of Conservative and Endodontics, Index Institute of Dental Sciences, Indore, Madhya Pradesh, India.

Masseter hypertrophy is a characteristic condition resulting from an increase in the size of the muscle mass. At times, it produces significant facial asymmetry and is an important finding in the differential diagnosis of similar located entities. A proper diagnosis of this condition would avoid more aggressive and unwarranted therapy by an inexperienced clinician who may mistake it for a more serious pathologic condition. Read More

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December 2018
1 Read

Laminin is over expressed in breast cancer and facilitate cancer cell metastasis.

J Cancer Res Ther 2018 Dec;14(Supplement):S1170-S1172

Department of Thyroid and Breast Surgery, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou 225001, Jiangsu, P.R. China.

Aim Of Study: Breast cancer invasion and metastasis is the main reason for the failure, and laminin is involved in it. This study intends to explore the expression of laminin in breast cancer and normal breast tissue and its clinical significance.

Materials And Methods: We use immunohistochemical assay for the detection of breast infiltrating ductal cancer tissues and normal breast tissues of laminin expression and discuss their role in breast cancer invasion and metastasis. Read More

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December 2018
1 Read

Optical coherence tomography imaging of melanoma skin cancer.

Lasers Med Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

No consensus guidelines exist on the use of optical coherence tomography (OCT) for diagnosis of cutaneous melanoma. The objectives of this review are to provide a descriptive review of the literature on characteristics of cutaneous melanomas seen on high-definition OCT (HD-OCT), speckle variance OCT (SV-OCT), and conventional OCT and to compare their diagnostic ability with that of histopathology. A review of PubMed and Google Scholar identified all available literature on OCT in melanoma skin cancer that included all in vivo and ex vivo studies on human or human tissues and excluded all studies on non-human subjects or animal studies. Read More

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December 2018
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Impact of different approaches to calculation of treatment activities on achieved doses in radioiodine therapy of benign thyroid diseases.

EJNMMI Phys 2018 Dec 12;5(1):32. Epub 2018 Dec 12.

Department of Nuclear Medicine, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Purpose: Radioiodine has been used for the treatment of benign thyroid diseases for over 70 years. However, internationally, there is no common standard for pretherapeutic dosimetry to optimally define the individual therapy activity. Here, we analyze how absorbed tissue doses are influenced by different approaches to pretherapeutic activity calculation of varying complexity. Read More

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December 2018

The effects of radiosynoviorthesis in pigmented villonodular synovitis of the knee.

Arch Orthop Trauma Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.

Introduction: Tenosynovial giant-cell tumor also known as pigmented villonodular synovitis (PVS) is a benign but aggressive synovial proliferative disease most often affecting the knee joint. The mainstay of therapy is surgical resection. Due to a high rate of local recurrence, radiosynoviorthesis (RSO) is used as an adjuvant method in many cases. Read More

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December 2018

Objective image analysis of non-magnifying image-enhanced endoscopy for diagnosis of small depressed early gastric cancers.

Endosc Int Open 2018 Dec 10;6(12):E1445-E1453. Epub 2018 Dec 10.

Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

 Gastric cancers (GC) after eradication are difficult to diagnose even by magnifying narrow-band imaging (NBI) or blue laser imaging (BLI) endoscopy. Little is known with regard to non-magnifying (NM)-NBI/BLI for early GC so we examined the efficacy of NM-NBI/BLI for early GC diagnosis.  We retrospectively analyzed the images of 29 small (≤ 1 cm) intramucosal GC that had been treated with endoscopic submucosal dissection and 137 benign depressed lesions (BDLs). Read More

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December 2018
2 Reads

Selective Progesterone Receptor Modulators for the Medical Treatment of Uterine Fibroids with a Focus on Ulipristal Acetate.

Biomed Res Int 2018 24;2018:1374821. Epub 2018 Jun 24.

Universitäts-Frauenklinik Heidelberg, Germany.

Uterine fibroids are the most frequent benign tumours in women of child-bearing age. Their symptoms are diverse and the quality of life of the women affected can be significantly impaired. While treatment to date has been primarily by means of surgical intervention, selective progesterone receptor modulators (SPRMs) open up new medication-based treatment options. Read More

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An Unusual Adenomatoid Tumor of Fimbria with Pronounced Psammoma Bodies in a BRCA Positive Patient as a Pitfall for Carcinoma on Frozen Section.

Case Rep Pathol 2018 21;2018:8148147. Epub 2018 Nov 21.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Background: BRCA gene mutations significantly increase the risk of breast and ovarian cancers where the lifetime risk of the ovarian cancer is about 40%. Therefore, many women with such mutations undergo prophylactic bilateral mastectomy and salpingo-oophorectomy. About 5-6% of these individuals display occult carcinomas in tubo-ovarian locations of which over 85% are tubal in origin. Read More

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November 2018

Reduced Levels of ATP Synthase Subunit ATP5F1A Correlate with Earlier-Onset Prostate Cancer.

Oxid Med Cell Longev 2018 14;2018:1347174. Epub 2018 Nov 14.

Division of Experimental Urology, Department of Urology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Switching of cellular energy production from oxidative phosphorylation (OXPHOS) to aerobic glycolysis occurs in many types of tumors. However, the significance of energy metabolism for the development of prostate carcinoma is poorly understood. We investigated the expression of OXPHOS complexes in 94 human prostate carcinomas and paired benign tissue using immunohistochemistry. Read More

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November 2018

Exposure to cuticular bacteria can alter host behavior in a funnel-weaving spider.

Curr Zool 2018 Dec 16;64(6):721-726. Epub 2017 Nov 16.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.

Contact with environmental microbes are arguably the most common species interaction in which any animal participates. Studies have noted diverse relationships between hosts and resident microbes, which can have strong consequences for host development, physiology, and behavior. Many of these studies focus specifically on pathogens or beneficial microbes, while the benign microbes, of which the majority of bacteria could be described, are often ignored. Read More

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December 2018

Update of Pheochromocytoma Syndromes: Genetics, Biochemical Evaluation, and Imaging.

Front Endocrinol (Lausanne) 2018 27;9:515. Epub 2018 Nov 27.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

Pheochromocytomas and paragangliomas (PCCs/PGLs) are rare commonly benign neuroendocrine tumors that share pathology features and clinical behavior in many cases. While PCCs are chromaffin-derived tumors that arise within the adrenal medulla, PGLs are neural-crest-derived tumors that originate at the extraadrenal paraganglia. Pheochromocytoma-paraganglioma (PPGL) syndromes are rapidly evolving entities in endocrinology and oncology. Read More

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November 2018

First two cases of craniomaxillofacial fibrous dysplasia from Nepal - case series.

Clin Cosmet Investig Dent 2018 26;10:269-274. Epub 2018 Nov 26.

Department of Oral and Maxillofacial Surgery, Chitwan Medical College and Teaching Hospital, Bharatpur-10, Chitwan, Nepal.

Fibrous dysplasia is a benign fibro-osseous disease of the bone, which is most commonly associated with congenital mutations in cAMP regulating protein Gsα coded by gene. Often it is seen involving the craniofacial skeleton and can range from an asymptomatic monostotic form to polyostotic variant involving almost all the bones of the skull, thereby leading to functional and esthetic problems. This requires a continuous monitoring of the involved region throughout the life of the patient, even after the surgical interventions. Read More

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November 2018

High mobility group box 3 as an emerging biomarker in diagnosis and prognosis of hepatocellular carcinoma.

Cancer Manag Res 2018 20;10:5979-5989. Epub 2018 Nov 20.

Medical School of Nantong University, Nantong 226001, Jiangsu, China,

Purpose: High mobility group box 3 (HMGB3) is associated with hepatocytes malignant transformation by our previous work. We continued to investigate the diagnostic and prognostic values of HMGB3 for hepatocellular carcinoma (HCC).

Patients And Methods: Circulating HMGB3 levels were quantitatively detected in a cohort of 225 patients with chronic liver diseases by ELISA and compared with alpha-fetoprotein by the receiver operating characteristic curve. Read More

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November 2018
1 Read

Madelung's disease - progressive, excessive, and symmetrical deposition of adipose tissue in the subcutaneous layer: case report and literature review.

Diabetes Metab Syndr Obes 2018 26;11:819-825. Epub 2018 Nov 26.

Department of Surgery with Trauma, Orthopaedic and Urological Subunit, Independent Public Health Care Center of the Ministry of Interior and Administration in Lublin, Lublin, Poland,

Madelung's disease is a rare disorder described for the first time in the year 1846 by Brodie. It is characterized by the occurrence of progressive, excessive, and symmetrical deposits of adipose tissue in the subcutaneous layer. Most often, these changes concern the neck, the nape of the neck, arms, and upper back, giving the patients a specific, pseudoathletic appearance. Read More

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November 2018

Vasoformative Lesions in Mediastinal Mixed Germ Cell Tumors: an Interesting Account of Two Cases Spanning the Benign to Malignant Spectrum.

Indian J Surg Oncol 2018 Dec 18;9(4):624-628. Epub 2018 May 18.

1Department of Histopathology, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India.

Extragonadal germ cell tumors are most commonly encountered in the anterior mediastinum. The presence of sarcomatous malignancies in these tumors is a rare phenomenon that adversely impacts patient prognosis because of poor response to conventional cisplatin-based chemotherapy. Even more unusual is the presence of florid benign somatic proliferations that overshadow the germ cell component, often resulting in misdiagnosis and inappropriate management. Read More

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December 2018
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Granular Cell Tumour in Stomach: a Case Report.

Indian J Surg Oncol 2018 Dec 21;9(4):598-600. Epub 2018 Jul 21.

Department of Pathology, Seth GSMC & KEMH, Parel, Mumbai-12, India.

Granular cell tumours are uncommon, usually benign soft tissue tumours. They are thought to be neural, arising from Schwann cells and can occur at various sites. Their occurrence in gastrointestinal tract is rare, the commonest site being oesophagus followed by large intestine. Read More

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December 2018
1 Read

Desmoplastic Fibroma of Bone: a Case Series and Review of Literature.

Indian J Surg Oncol 2018 Dec 18;9(4):585-591. Epub 2018 May 18.

4Department of Radiation Oncology, Lok Nayak Hospital, Delhi, India.

Desmoplastic fibroma is an uncommon locally aggressive benign tumor of the bone. Patients usually present with a long-standing history of pain and swelling. Radiologically and histologically, it can mimic a variety of tumors. Read More

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December 2018

Cerebral Venous Thrombosis: An Uncommon Cause of Papilledema on Bedside Ocular Ultrasound.

J Emerg Med 2018 Dec 8. Epub 2018 Dec 8.

Department of Emergency Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida.

Background: Cerebral venous thrombosis (CVT) is a rare, difficult-to-diagnose form of venous thromboembolic disease and is considered a type of stroke. Its presentation is highly variable and may be easily confused for more common and less debilitating or life-threatening diagnoses such as migraine, seizure, or idiopathic intracranial hypertension.

Case Report: A 25-year-old woman presented with a complaint of bifrontal throbbing headache and blurry vision. Read More

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December 2018

Idiopathic calcinosis cutis of the scrotum: a case report and review of the literature.

J Med Case Rep 2018 Dec 12;12(1):366. Epub 2018 Dec 12.

Department of Dermatology and Venereology, Institute of Medicine, Tribhuvan University, Maharajgunj, Kathmandu, Nepal.

Background: Abnormal deposition of calcium in the skin or subcutaneous tissue is termed calcinosis cutis. Idiopathic calcinosis cutis of the scrotum is an uncommon entity. The pathogenesis of idiopathic calcinosis cutis of the scrotum is debatable. Read More

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December 2018
1 Read

A natural history of apical hypertrophic cardiomyopathy with development of an apical aneurysm formation: A case report following a quarter century.

J Cardiol Cases 2014 Jun 6;9(6):221-225. Epub 2014 Mar 6.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo, Japan.

We report the definite long-term natural history of a man with apical hypertrophic cardiomyopathy (ApHCM), who developed an apical aneurysm by the age of 60 years. At 33 years, his electrocardiogram (ECG) was nearly normal. T-wave inversions were first identified in leads V5-6 of an ECG at 36 years of age. Read More

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Surgical management of giant fibroelastoma of the aortic valve with repair through valve sparing technique.

J Cardiol Cases 2014 May 14;9(5):187-188. Epub 2014 Feb 14.

Division of Cardiac Surgery, Spitali Europian - GVM Care & Research, Tiranë, Albania.

Background: Fibroelastomas account for less than 10% of all cardiac tumors, representing the most common valvular and the second most common cardiac benign tumor, following myxomas.Fibroelastomas are histologically benign, but they can result in life-threatening complications such as stroke, acute valvular dysfunction, embolism, ventricular fibrillation, and sudden death.

Methods: A valve-sparing technique with simple shave excision of the tumor was undertaken with success. Read More

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Papillary fibroelastoma of the mitral valve chordae with systemic embolization.

J Cardiol Cases 2014 Oct 15;10(4):125-128. Epub 2014 Jul 15.

Wake Forest Baptist Medical Center, Winston Salem, NC, USA.

Papillary fibroelastoma (PFE) is a rare benign tumor that most commonly involves heart valves. Cardiac PFE involving the mitral chorda is rarer. Most papillary PFE are asymptomatic; rarely, they are diagnosed because of cardiac symptoms or after an embolic event. Read More

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October 2014

Left atrial myxofibrosarcoma: Diagnostic approach through imaging techniques.

J Cardiol Cases 2013 Jun 18;7(6):e164-e167. Epub 2013 Mar 18.

La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.

Primary cardiac sarcomas are rare. A 63-year-old woman presented with progressive symptoms of fatigue, palpitations, and dyspnea. Transthoracic echocardiography detected a mass in the left atrium, fixed and probably attached to the interatrial septum suggestive of myxoma. Read More

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A primary cardiac osteosarcoma: Case report and review of the literature.

J Cardiol Cases 2013 Feb 24;7(2):e29-e33. Epub 2012 Oct 24.

Department of Pathology, Hospital Edgardo Rebagliati Martins, Lima, Peru.

Primary cardiac osteosarcoma is a rare and aggressive neoplasm that can be difficult to diagnose. We report a case of a previously healthy 49-year-old woman who presented with dyspnea, atrial flutter, and heart failure. A mass was visualized in her left atrium by echocardiography and cardiac computed tomography, and the diagnosis of cardiac myxoma was raised. Read More

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February 2013

Acute pulmonary embolism induced by renal obstruction with benign prostatic hyperplasia: Case report.

J Cardiol Cases 2012 Feb 21;5(1):e39-e43. Epub 2011 Nov 21.

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

Background: We report a rare case of acute pulmonary embolism (PE) induced by urinary retention and bladder distention with benign prostatic hyperplasia (BPH).

Case Report: A 76-year-old male with BPH presented to the hospital with anuria of 24 h duration and abdominal distention. Physical examination revealed tenderness and distention of the lower abdomen and a swollen right leg. Read More

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February 2012

Acute myocardial infarction involving double vessel total occlusion of the left anterior descending and left circumflex arteries: A case report.

J Cardiol Cases 2011 Aug 15;4(1):e1-e4. Epub 2011 Jun 15.

Department of Cardio-Angiology, School of Medicine, Kitasato University, Sagamihara, Japan.

A 66-year-old Japanese man complained of chest pain consistent with acute myocardial infarction (AMI). His electrocardiogram showed ST segment elevation in the anterior and inferior leads. Emergency coronary angiography revealed occlusion of the proximal left anterior descending artery (LAD) and middle left circumflex artery (LCx). Read More

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A case of caseous calcification of the mitral annulus: A potential source of embolic stroke.

J Cardiol Cases 2010 Dec 7;2(3):e141-e143. Epub 2010 Jul 7.

Division of Cardiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.

Mitral annular calcification (MAC) is a common finding especially among the elderly. Caseous calcification of the mitral annulus (CCMA) is a rare variant of MAC, which may be mistaken for an intracardiac tumor or abscess. The clinical significance of CCMA and its potential as a source for cerebral embolism is not known. Read More

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December 2010

Expression Levels of microRNAs miR-93 and miR-200a in Pancreatic Adenocarcinoma with Special Reference to Differentiation and Relapse-Free Survival.

Oncology 2018 Dec 11:1-7. Epub 2018 Dec 11.

Department of Pathology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

Objectives: Protein levels of the transcription factor nuclear factor erythroid-derived 2-like 2 (Nrf2) and its inhibitor Kelch-like ECH-associated protein 1 (Keap1) have been proposed as prognostic factors in pancreatic ductal adenocarcinomas (PDACs). These cellular redox-state-regulating enzymes are targeted by several microRNAs, including miR-93 and miR-200a.

Methods: We assessed mRNA levels of Nrf2 and Keap1 and tissue expression of miR-93 and miR-200a in 51 patients with surgically treated PDAC. Read More

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December 2018
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Role and mechanisms of a three-dimensional bioprinted microtissue model in promoting proliferation and invasion of growth-hormone-secreting pituitary adenoma cells.

Biofabrication 2018 Dec 11. Epub 2018 Dec 11.

Department of Mechanical Engineering, Biomanufacturing Center, Tsinghua University, Beijing, CHINA.

Growth-hormone-secreting pituitary adenoma (GHSPA) is a benign tumour with a high incidence and large economic burden, which greatly affects quality of life. The aetiological factors are yet to be clarified for GHSPA. Conventional two-dimensional (2D) monolayer culture of tumour cells cannot ideally reflect the growth status of tumours in the physiological environment, and insufficiencies of in vitro models have severely restricted the progress of cancer research. Read More

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December 2018

Environmentally benign conversion of waste polyethylene terephthalate to fluorescent carbon dots for "on-off-on" sensing of ferric and pyrophosphate ions.

J Colloid Interface Sci 2018 Dec 4;538:481-488. Epub 2018 Dec 4.

School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China. Electronic address:

The increasing production of waste polyethylene terephthalate (PET) is a growing problem worldwide. Environmentally benign conversion of waste PET to valuable materials remains a substantial challenge. In this paper, we developed a green route to reuse waste PET for low-cost synthesis of fluorescent carbon dots (CDs) via air oxidation followed by hydrothermal treatment in aqueous HO solution. Read More

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December 2018
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Reactions in Water-A Greener Approach Using Ruthenium Catalysts.

Chem Rec 2018 Dec 7. Epub 2018 Dec 7.

Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, 500007.

Reactions using transition metals as catalysts have emerged as an efficient method in the recent times. However, the selection of solvent plays a crucial role in this regard. Several solvents used traditionally suffer majorly with problems of toxicity; high boiling point etc. Read More

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December 2018

Interfacial Coupling Boosts Giant Electrocaloric Effects in Relaxor Polymer Nanocomposites: In Situ Characterization and Phase-Field Simulation.

Adv Mater 2018 Dec 9:e1801949. Epub 2018 Dec 9.

School of Materials Science and Engineering, State Key Lab of New Ceramics and Fine Processing, Tsinghua University, Beijing, 100084, China.

The electrocaloric effect (ECE) refers to reversible thermal changes of a polarizable material upon the application or removal of electric fields. Without a compressor or cooling agents, all-solid-state electrocaloric (EC) refrigeration systems are environmentally benign, highly compact, and of very high energy efficiency. Relaxor ferroelectric ceramics and polymers are promising candidates as EC materials. Read More

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December 2018

Virtual evaluation of selected cervical lymph nodes with three-dimensional ultrasound in thyroid cancer patients after thyroidectomy.

Head Neck 2018 Dec 9. Epub 2018 Dec 9.

Department of Medicine and Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, New York.

Background: We evaluated the usefulness of three-dimensional (3D) ultrasound of cervical lymph nodes (LN), when two-dimensional (2D) ultrasound evaluation is not sufficient to clearly evaluate lymph node characteristics, in thyroid cancer patients being followed after thyroidectomy.

Methods: Two readers retrospectively analyzed 2D and 3D images of 147 LNs; LNs were categorized as normal, reactive, suspicious, or indeterminate, and confidence level was rated. Results were compared to cytological/clinical data. Read More

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December 2018

Voxel-wise correlation of PET/CT with multiparametric MRI and histology of the prostate using a sophisticated registration framework.

BJU Int 2018 Dec 10. Epub 2018 Dec 10.

School of Physics, The University of Sydney, Sydney, New South Wales, Australia.

Objectives: To develop a registration framework for correlating positron emission tomography/computed tomography (PET/CT) images with multiparametric MRI (mpMRI) and histology of the prostate, thereby enabling voxel-wise analysis of imaging parameters.

Patients And Methods: In this prospective proof-of-concept study, nine patients scheduled for radical prostatectomy underwent mpMRI and PET/CT imaging prior to surgery. One had PET imaging using F-fluoromethylcholine (FCH), five using Ga-labelled prostate-specific membrane antigen (PSMA)-HBED-CC (PMSA-11) and three using a trial Ga-labelled THP-PSMA tracer. Read More

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December 2018
2 Reads

Prostate cancer induces C/EBPβ expression in surrounding epithelial cells which relates to tumor aggressiveness and patient outcome.

Prostate 2018 Dec 11. Epub 2018 Dec 11.

Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.

Background: Implantation of rat prostate cancer cells into the normal rat prostate results in tumor-stimulating adaptations in the tumor-bearing organ. Similar changes are seen in prostate cancer patients and they are related to outcome. One gene previously found to be upregulated in the non-malignant part of tumor-bearing prostate lobe in rats was the transcription factor CCAAT/enhancer-binding protein-β (C/EBPβ). Read More

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December 2018
1 Read

Relationship between Hashimoto's thyroiditis and papillary thyroid carcinoma in children and adolescents.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7778-7787

Department of Oncology, The First People's Hospital of Yunnan Province, Kunming, China.

Objective: We investigated the relationship between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) in children and adolescents.

Patients And Methods: We carried out a retrospective study of thyroidectomies performed from 2004 to 2017 at The First People's Hospital and the Tumor Hospital of Yunnan Province (Kunming, China). The occurrence and features of PTC and benign thyroid disease (BTD) in children and adolescents (age ≤ 20 years) were compared. Read More

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November 2018

[Management of vestibular schwannomas].

Laryngorhinootologie 2018 Dec 10;97(12):875-896. Epub 2018 Dec 10.

Vestibular schwannomas are benign neoplasms originating from the Schwann cells of the vestibular vestibular nerve of the vestibulocochlear nerve, and rarely from the pars cochlearis. These are tumors that are in contact with the nerve but do not bind the fibers. Benign neoplasms of the Schwann cells of the auditory and equilibrium nerves can also occur primarily in the inner ear and are referred to as intralabyrinthine schwannomas (ILS). Read More

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December 2018
1 Read

Safe adoption of robotic colorectal surgery using structured training: early Irish experience.

J Robot Surg 2018 Dec 10. Epub 2018 Dec 10.

Beacon Hospital, Beacon Court, Sandyford, Dublin 18, Republic of Ireland.

Robotic surgery enhances the precision of minimally invasive surgery through improved three-dimensional views and articulated instruments. There has been increasing interest in adopting this technology to colorectal surgery and this has recently been introduced to the Irish health system. This paper gives an account of our early institutional experience with adoption of robotic colorectal surgery using structured training. Read More

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December 2018
2 Reads

A propensity score matched comparison of intracorporeal and extracorporeal techniques for robotic-assisted sigmoidectomy in an enhanced recovery pathway.

J Robot Surg 2018 Dec 10. Epub 2018 Dec 10.

Division of Colon and Rectal Surgery, St. Joseph Mercy Hospital, Ann Arbor, 5325 Elliott Dr., Suite #104, Ann Arbor, MI, 48106, USA.

Intracorporeal options for sigmoid resection have been recently developed but not extensively evaluated. This study was designed to assess outcomes comparing intracorporeal and extracorporeal techniques for robotic-assisted sigmoid resection in an established enhanced recovery pathway. This is a retrospective comparison of intracorporeal and extracorporeal techniques for robotic-assisted sigmoid resection for benign and malignant disease. Read More

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December 2018
1 Read

Incidental findings on 18-FDG PET-CT in head and neck cancer. A retrospective case-control study of incidental findings on 18-FDG PET-CT in patients with head and neck cancer.

Eur Arch Otorhinolaryngol 2018 Dec 10. Epub 2018 Dec 10.

Department of Ear, Nose, and Throat Surgery, Oxford University Hospital NHS Foundation Trust, Oxford, UK.

Purpose: Use of 18-FDG PET-CT is increasing in patients with head and neck cancer, enabling the identification of metastases or synchronous malignancies, but also 'incidental' disease. We aimed to establish the rate of 'incidental' findings resulting from 18-FDG PET-specific imaging, that would not have been otherwise identified on other imaging, in patients with head and neck cancer undergoing staging or surveillance of disease.

Methods: 18-FDG PET-CT was performed for investigation or surveillance. Read More

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December 2018

Gamma Knife radiosurgery for intravestibular and intracochlear schwannomas.

Acta Neurochir (Wien) 2018 Dec 8. Epub 2018 Dec 8.

Centre Hospitalier Universitaire Vaudois (CHUV), Neurosurgery Service and Gamma Knife Center, Rue du Bugnon 44-46, BH-08, CH-1011, Lausanne, Switzerland.

Background: Schwannomas of the VIIIth cranial nerve are benign tumours, with vast majority occurring in vestibular division. Rarely, they can also arise from distal branches of cochlear, superior or inferior vestibular. We review our experience with Gamma Knife radiosurgery (GKR), as first intention treatment for intracochlear (ICS) and intravestibular (IVS) schwannomas. Read More

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December 2018
1 Read

Comprehensive anatomical and functional imaging in patients with type I neurofibromatosis using simultaneous FDG-PET/MRI.

Eur J Nucl Med Mol Imaging 2018 Dec 8. Epub 2018 Dec 8.

Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Hoppe-Seyler-Str.3, 72076, Tuebingen, Germany.

Purpose: To demonstrate the clinical use of FDG-PET/MRI for monitoring enlargement and metabolism of plexiform neurofibromas (PNF) in patients with neurofibromatosis type 1 (NF1), in whom the development of a malignant peripheral nerve sheath tumor (MPNST) is often a life limiting event.

Methods: NF1 patients who underwent a simultaneous FDG-PET/MRI examination in our institution from September 2012 to February 2018 were included. Indication was suspicion of malignant transformation of a PNF to MPNST. Read More

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December 2018

F-FDG PET/CT diagnostic performance in solitary and multiple pulmonary nodules detected in patients with previous cancer history: reports of 182 nodules.

Eur J Nucl Med Mol Imaging 2018 Dec 8. Epub 2018 Dec 8.

Nuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito, 1, 00168, Roma, Italia.

Purpose: In oncological patients, F-FDG PET/CT performance for pulmonary nodules' characterization is not well-established. Thus, the purpose of this study was to evaluate the F-FDG PET/CT diagnostic performance in pulmonary nodules detected during follow-up in oncological patients and the relationship between malignancy and nodules' characteristics.

Methods: We retrospectively evaluated 182 pulmonary nodules (121 solitary, 61 multiple; mean size = 16. Read More

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December 2018

Diffusion-weighted imaging and diffusion tensor imaging as adjuncts to conventional MRI for the diagnosis and management of peripheral nerve sheath tumors: current perspectives and future directions.

Eur Radiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiology, UT Southwestern Medical Center, Dallas, TX, 75022, USA.

Peripheral nerve sheath tumors (PNSTs) account for ~ 5% of soft tissue neoplasms and are responsible for a wide spectrum of morbidities ranging from localized neuropathy to fulminant metastatic spread and death. MR imaging represents the gold standard for identification of these neoplasms, however, current anatomic MR imaging markers do not reliably detect or differentiate benign and malignant lesions, and therefore, biopsy or excision is required for definitive diagnosis. Diffusion-weighted MR imaging (DWI) serves as a useful tool in the evaluation and management of PNSTs by providing functional information regarding the degree of diffusion, while diffusion tensor imaging (DTI) aids in determining the directional information of predominant diffusion and has been shown to be particularly useful for pre-operative planning of these tumors by delineating healthy and pathologic fascicles. Read More

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December 2018

Compound odontoma - morphology, clinical findings and treatment. Case report.

Rom J Morphol Embryol 2018 ;59(3):997-1000

Department of Ergonomics and Scientific Research Methodology, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Eforiei Dental Clinic, Bucharest, Romania;

Compound odontomas are benign tumors, composed of odontogenic tissue that has an orderly pattern. These are formed of unilocular conglomerate of multiple calcified structures, some resembling to mini-teeth. A case of a 9-year-old female patient with compound odontoma is reported, highlighting aspects of odontoma's morphology, clinical findings and treatment. Read More

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January 2018
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