9,376 results match your criteria Benign Lung Tumors


Surgical Outcomes in a Lung Cancer-Screening Program Using Low Dose Computed Tomography.

Arch Bronconeumol 2020 Apr 23. Epub 2020 Apr 23.

Departamento de Neumología, Clínica Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.

Objective: Lung cancer (LC) is the leading cause of death from cancer worldwide. More than 27,000 LCs are diagnosed annually in Spain, and most are unresectable. Early detection and treatment reduce LC mortality. Read More

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http://dx.doi.org/10.1016/j.arbres.2020.03.026DOI Listing

Cutaneous Scalp Metastases of Malignant Phyllodes Tumor of the Breast.

J Breast Cancer 2020 Jun 27;23(3):320-325. Epub 2020 Feb 27.

Department of Surgery, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea.

Phyllodes tumor (PT) of the breast is a relatively rare fibroepithelial tumor that accounts for < 1% of primary breast neoplasms. PT is classified histologically as benign, borderline, or malignant, and a malignant PT has greater potential to metastasize than benign PT. Although almost all other organs can be affected, common metastatic sites are the lung and bone via the hematogenous route. Read More

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http://dx.doi.org/10.4048/jbc.2020.23.e18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311367PMC

Recurrent hyperparathyroidism due to parathyroid and pulmonary tumors showing features of parathyroid adenoma.

Radiol Case Rep 2020 Aug 18;15(8):1289-1294. Epub 2020 Jun 18.

Department of Pathology, St. Marianna University School of Medicine University Hosital, Kawasaki, Kanagawa, Japan.

We report on a case of recurrent primary hyperparathyroidism possibly caused by parathyroid adenocarcinoma metastasizing to the lung. A 46-year-old woman with a history of parathyroid adenoma, which was extirpated 8 years ago, presented with symptoms of primary hyperparathyroidism, and was found to have a parathyroid and a lung nodule in radiographic assessments. Resections of the tumors in the parathyroid gland as well as the lung were required to improve her condition, and in pathology, both tumors demonstrated benign features consistent with adenoma. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306540PMC

Myeloid diseases in the lung and pleura.

Semin Diagn Pathol 2020 Jun 12. Epub 2020 Jun 12.

Department of Pathology, UT Southwestern Medical Center, BioCenter EB3.234, 2330 Inwood Road, EB3.234, Dallas, TX 75390-9317, USA. Electronic address:

Myeloid diseases detected as primary or secondary lesions in the lung and pleura are rare. Clinical presentations and radiographic results may vary significantly depending on the nature of the diseases. The most common diseases associated with lung and pleura involvement are myeloid sarcoma/acute myeloid leukemia (AML) and extramedullary hematopoiesis (EMH). Read More

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http://dx.doi.org/10.1053/j.semdp.2020.06.002DOI Listing

Pulmonary sclerosing pneumocytoma in an 18-year-old male patient: A case report and literature review.

Medicine (Baltimore) 2020 Jun;99(26):e20869

Director of Vietnam Military Medical University, Hanoi, Vietnam.

Rationale: Pulmonary sclerosing pneumocytoma (PSP) is a rare benign tumor of the lung, mostly presented in Asian middle-aged women. Initially, it was considered as a vascular origin tumor, but then research evidence showed that it was derived from natural epithelial tissue. On imaging, this tumor may be found as a solitary well-circumscribed lung parenchymal lesion, and is often located in juxtapleural or juxtafissural positions. Read More

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http://dx.doi.org/10.1097/MD.0000000000020869DOI Listing

Angiomyolipoma of the adrenal gland: clinical experience and literature review.

Ann Transl Med 2020 May;8(10):654

Department of Radiology, the Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Zunyi 563000, China.

Angiomyolipomas, a type of benign mesenchymal tumor originating from perivascular epithelioid cells, are composed of mature adipose tissue, smooth muscle, and thick-walled vessels. With fewer than 20 cases reported in English literature, adrenal angiomyolipoma is extremely rare. In these cases, the patient is usually asymptomatic and the tumor is found incidentally. Read More

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http://dx.doi.org/10.21037/atm-20-3147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290629PMC

Napsin A is a highly sensitive marker for nephrogenic adenoma: an immunohistochemical study with specificity test in genitourinary tumors.

Hum Pathol 2020 Jun 16. Epub 2020 Jun 16.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States. Electronic address:

Nephrogenic adenomas are uncommon benign lesions that are typically cytologically bland, but degenerative and reactive changes may make it difficult to distinguish these lesions from malignant entities, such as urothelial carcinoma and prostatic adenocarcinoma. In this study, we explored whether napsin A, a sensitive marker for lung adenocarcinoma, may also have a role in distinguishing nephrogenic adenoma from other genitourinary lesions. Immunohistochemically, napsin A was expressed in all 43 nephrogenic adenomas (bladder 38, prostatic urethra 4, and ureter 1; mean positive tumor cells 72%, median 80%, range 15-100%) and showed regional variability in its expression pattern with a bias towards surface architectures (flat, papillary) compared to stromal architectures (tubular/glandular, microcystic). Read More

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http://dx.doi.org/10.1016/j.humpath.2020.05.007DOI Listing

A Rare Cause of Cough: Tracheobronchial Myxoid Spindle Cell Lipoma.

Case Rep Pulmonol 2020 30;2020:9727281. Epub 2020 May 30.

Integrated Sleep Care, Miramar, FL, USA.

Background: Endobronchial lipomas are a particularly rare form of benign lung neoplasms, with an incidence of 0.1-0.4%. Read More

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http://dx.doi.org/10.1155/2020/9727281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277026PMC

[Analysis of clinicopathological features of clear cell tumor of the lung].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(22):1736-1740

Pathology Department of the First Medical Center of PLA General Hospital, Beijing 100853, China.

To analyze the clinicopathological features of clear cell tumor of the lung (CCTL). A total of 9 cases were collected from August 2008 to August 2019 in the Department of Pathology of the First Medical Center of PLA General Hospital and Hainan Hospital of PLA General Hospital. Their clinical data, pathological characteristics, immunohistochemical staining and special staining results were summarized and analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200106-00033DOI Listing

Pathologic categorization of lung nodules: Radiomic descriptors of CT attenuation distribution patterns of solid and subsolid nodules in low-dose CT.

Eur J Radiol 2020 May 31;129:109106. Epub 2020 May 31.

Department of Radiology, University of Michigan, Ann Arbor, United States.

Purpose: Develop a quantitative image analysis method to characterize the heterogeneous patterns of nodule components for the classification of pathological categories of nodules.

Materials And Methods: With IRB approval and permission of the National Lung Screening Trial (NLST) project, 103 subjects with low dose CT (LDCT) were used in this study. We developed a radiomic quantitative CT attenuation distribution descriptor (qADD) to characterize the heterogeneous patterns of nodule components and a hybrid model (qADD+) that combined qADD with subject demographic data and radiologist-provided nodule descriptors to differentiate aggressive tumors from indolent tumors or benign nodules with pathological categorization as reference standard. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109106DOI Listing

Incorporating ToxCast™ data into naphthalene human health risk assessment.

Toxicol In Vitro 2020 Jun 9;67:104913. Epub 2020 Jun 9.

Gradient, One Beacon Street, Boston, MA 02108, United States of America.

Chronic inhalation of naphthalene causes nasal olfactory epithelial tumors in rats and benign lung adenomas in mice. The available human data do not establish an association between naphthalene and increased respiratory cancer risk. Therefore, cancer risk assessment of naphthalene in humans depends predominantly on experimental evidence from rodents. Read More

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http://dx.doi.org/10.1016/j.tiv.2020.104913DOI Listing

PD-1/PD-L1 negative schwannoma mimicking obstructive bronchial malignancy: A case report.

Thorac Cancer 2020 Jun 8. Epub 2020 Jun 8.

Department of Respiratory and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Schwannomas are homogeneous tumors of schwann cells and occur at peripheral and cranial nerves on the upper limbs, the head and neck area. Rarely, a bronchial schwannoma may appear in the lung and be misdiagnosed as lung neoplasms. Here, we report a 56-year old woman with a 5. Read More

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http://dx.doi.org/10.1111/1759-7714.13505DOI Listing

The two faces of giant cell tumor of bone.

Cancer Lett 2020 Jun 2;489:1-8. Epub 2020 Jun 2.

Institute of Genetics and Biophysics "Adriano Buzzati-Traverso", National Research Council of Italy, Naples, Italy. Electronic address:

Giant cell tumor (GCT) is a bone-destructive benign neoplasm characterized by distinctive multinucleated osteoclast-like giant cells with osteolytic properties distributed among neoplastic stromal cells. GCT is locally aggressive with progressive invasion of adjacent tissues and occasionally displays malignant characteristics including lung metastasis. GCT is characterized genetically by highly recurrent somatic mutations at the G34 position of the H3F3A gene, encoding the histone variant H3. Read More

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http://dx.doi.org/10.1016/j.canlet.2020.05.031DOI Listing
June 2020
5.621 Impact Factor

Cancer Stem-Like Cells in a Case of an Inflammatory Myofibroblastic Tumor of the Lung.

Front Oncol 2020 15;10:673. Epub 2020 May 15.

Division of Thoracic Surgery, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Inflammatory myofibroblast tumor (IMT) is a rare tumor with obscure etiopathogenesis in which different inflammatory cells and myofibroblastic spindle cells are seen histologically. Although the majority of these neoplasms have a benign clinical course, the malignant form has also been reported. The gold standard is surgical treatment for complete removal. Read More

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http://dx.doi.org/10.3389/fonc.2020.00673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243805PMC

Self-expanding metallic Y-stent compared to silicone Y-stent for malignant lesions of the main carina: A single center retrospective study.

Respir Med Res 2020 May 24;78:100767. Epub 2020 May 24.

Department of Pulmonology, Thoracic Oncology and Respiratory Intensive Care & CIC- CRB 1404, Rouen University Hospital, 1, rue de Germont, 76000, Rouen, France; Normandie University, UNIROUEN, QuantIF- LITIS EA 4108, Department of Pulmonology, Rouen University Hospital, Thoracic Oncology and Respiratory Intensive Care & CIC- CRB 1404, 76000 Rouen, France.

Background: Bifurcation stents are often required in patients with malignant airway obstruction or fistulization involving the main carina. The silicone Y stent is the most used but remains challenging to place. The self-expanding metallic Y (SEM) stent appears easy to use. Read More

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http://dx.doi.org/10.1016/j.resmer.2020.100767DOI Listing

Misdiagnosis of Small Cell Prostate Cancer: Lessons Learned.

Cureus 2020 May 29;12(5):e8356. Epub 2020 May 29.

Genitourinary Oncology, Creighton University School of Medicine/University of Arizona Cancer Center at Dignity Health, Phoenix, USA.

Small cell carcinoma (SCC) of the prostate is rare in the spectrum of prostate tumors. Clinically, prostate SCC is more aggressive and has a poorer prognosis when compared to prostate acinar adenocarcinoma. Delay in diagnosis and misdiagnosis further worsens the outcome of this disease. Read More

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http://dx.doi.org/10.7759/cureus.8356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263708PMC

Doege-Potter Syndrome and Pierre-Marie-Bamberger Syndrome in a Patient With Pleural Solitary Fibrous Tumor: A Rare Case With Literature Review.

Cureus 2020 May 1;12(5):e7919. Epub 2020 May 1.

Internal Medicine, Creighton University Arizona Health Education Alliance/Valleywise Health Medical Center, Phoenix, USA.

Solitary fibrous tumors (SFT) represent a unique subset of mostly benign heterogeneous tumors with mesenchymal cell origins. These tumors have been reported in the past as being mostly indolent, with a slowly evolving clinical course and low potential for malignancy. Although found systemically, the incidence of SFT arising intrathoracically, from the pleura of the lung, is relatively poorly documented in the medical literature. Read More

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http://dx.doi.org/10.7759/cureus.7919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263730PMC

Intrapulmonary location of benign solitary fibrous tumor.

Ann Thorac Med 2020 Apr-Jun;15(2):98-101. Epub 2020 Apr 3.

Department of Radiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Region, Saudi Arabia.

Intrapulmonary solitary fibrous tumors (SFTs) are sporadic mesenchymal neoplasms that typically arise from visceral or parietal pleura. While accounting for <5% of all pleural tumors, SFTs are known to occur in nearly all bodily organs, including nasopharynx, bladder, prostate, soft tissue of neck, buttocks, extremities, and abdominal wall. Such tumors have been previously designated localized fibrous mesothelioma or pleural fibroma. Read More

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http://dx.doi.org/10.4103/atm.ATM_14_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259394PMC

Clinical Utility of Combined Circulating Tumor Cell and Circulating Tumor DNA Assays for Diagnosis of Primary Lung Cancer.

Anticancer Res 2020 Jun;40(6):3435-3444

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

Background/aim: Although it has been suggested that circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) might be used in a complementary manner in lung cancer diagnosis, limited confirmatory data are available. In this prospective study, we evaluated the diagnostic performance of each assay separately and in combination.

Patients And Methods: From March 2018 to January 2019, patients with suspected primary lung cancer, who underwent routine lung cancer work-up and peripheral blood sampling, were prospectively enrolled in the study. Read More

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http://dx.doi.org/10.21873/anticanres.14329DOI Listing

[Bronchiolar adenoma: a clinicopathological analysis of 15 cases].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):556-561

Department of Pathology, the First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) , Nanjing 210029, China.

To study the clinicopathological characteristics, diagnosis and differential diagnosis of bronchiolar adenoma (BA). Fifteen cases of BA were collected from the First Affiliated Hospital of Nanjing Medical University, from January 2016 to October 2019. The clinical data, imaging examination, morphology, immunostaining and molecular changes were retrospectively analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20191125-00755DOI Listing

Definitive lobectomy without frozen section analysis is a treatment option for large or deep nodules selected carefully with clinical diagnosis of malignancy.

Thorac Cancer 2020 Jul 22;11(7):1996-2004. Epub 2020 May 22.

Division of Thoracic Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

Background: Tissue harvesting for patients with a lung nodule is sometimes unsuitable due to the size and location of the nodule. In such cases, it is unclear whether it is acceptable to proceed to definitive lobectomy without intraoperative frozen section analysis.

Methods: We retrospectively reviewed patients who underwent definitive lobectomy or wedge resection for frozen section analysis at our institution between 2014 and 2018. Read More

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http://dx.doi.org/10.1111/1759-7714.13493DOI Listing

Identification of Sonographic Features for Predicting Benign Versus Malignant Mediastinal or Hilar Lymph Nodes Using Endobronchial Ultrasound.

Oman Med J 2020 Mar 30;35(2):e112. Epub 2020 Apr 30.

Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: In countries with a high prevalence of tuberculosis, such as Iran, the differentiation of malignant from non-malignant tumors is crucial. We attempted to find a reliable model in determining malignant nodes by investigating the sonographic characteristics of lymph nodes (LNs).

Methods: In this prospective study, the morphologic characteristics of LNs, including size, shape, vascular pattern, echogenicity, margin, coagulation necrosis sign, calcification, and central hilar structure, which had been obtained during endobronchial ultrasound-guided transbronchial needle aspiration, were compared with the final pathology results. Read More

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http://dx.doi.org/10.5001/omj.2020.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199125PMC

[Application of Radiomics in Classification and Prediction of Benign and Malignant Lung Tumors].

Zhongguo Yi Liao Qi Xie Za Zhi 2020 Feb;44(2):113-117

Zhejiang Pharmaceutical College, Ningbo, 315100.

Aiming at the lack of quantitative evaluation methods in clinical diagnosis of lung cancer, a classification and prediction model of lung cancer based on Support Vector Machine (SVM) was constructed by using radiomics method. Firstly, the definition and processing flow of radiomics were introduced. The experimental samples were selected from 816 lung cancer patients on LIDC. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2020.02.004DOI Listing
February 2020

[Introduction of Minimally Invasive Thoracoscopic Surgery for the Anterior Mediastinum;Subxiphoid Video-assisted Thoracoscopic Thymectomy and Robot-assisted Thymectomy].

Kyobu Geka 2020 Apr;73(4):274-279

Department of Thoracic Surgery, Kitasato University School of Medicine, Sagamihara, Japan.

In Japan, robot-assisted surgery for malignant lung tumors, benign mediastinal tumors, and malignant mediastinal tumors has been covered by the national health insurance since 2018. Hence, the number of domestic robotic surgical procedures is increasing. Recently, we introduced endoscopic surgery such as video-assisted thoracoscopic surgery (VATS) via a subxiphoidal approach for thymectomy. Read More

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[Usefulness of Long Shaft Stapler in Robot-assisted Thoracic Surgery Lung Resection].

Kyobu Geka 2020 Apr;73(4):270-273

Department of Thoracic Surgery, Tokyo Women's Medical University, Tokyo, Japan.

Since national health insurance began to cover robot-assisted thoracoscopic surgery (RATS) for malignant lung tumors, malignant mediastinal tumors, and benign mediastinal tumors in Japan starting in 2018, the number of RATS performed domestically has increased rapidly. In the case of undiagnosed lung tumor, it is necessary to perform a thoracoscopic lung biopsy in the port arrangement for RATS lung resection in the case of undiagnosed lung tumor. The 2 ports are placed in the same 8th intercostal space and a 3 cm utility thoracotomy is added to the 4th or 5th intercostal space for the thoracoscopic lung biopsy. Read More

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Radiomics and deep learning in lung cancer.

Strahlenther Onkol 2020 May 4. Epub 2020 May 4.

Department of Medical Physics, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Via F. Gallini 2, 33081, Aviano, PN, Italy.

Lung malignancies have been extensively characterized through radiomics and deep learning. By providing a three-dimensional characterization of the lesion, models based on radiomic features from computed tomography (CT) and positron-emission tomography (PET) have been developed to detect nodules, distinguish malignant from benign lesions, characterize their histology, stage, and genotype. Deep learning models have been applied to automatically segment organs at risk in lung cancer radiotherapy, stratify patients according to the risk for local and distant recurrence, and identify patients candidate for molecular targeted therapy and immunotherapy. Read More

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http://dx.doi.org/10.1007/s00066-020-01625-9DOI Listing

High Mobility Group AT-Hook 2 (HMGA2) Oncogenicity in Mesenchymal and Epithelial Neoplasia.

Int J Mol Sci 2020 Apr 29;21(9). Epub 2020 Apr 29.

Department of Anesthesiology, Columbia University Medical Center, 630 West 168th Street, P&S 12-402, New York, NY 10032, USA.

High mobility group AT-hook 2 (HMGA2) has been associated with increased cell proliferation and cell cycle dysregulation, leading to the ontogeny of varied tumor types and their metastatic potentials, a frequently used index of disease prognosis. In this review, we deepen our understanding of HMGA2 pathogenicity by exploring the mechanisms by which HMGA2 misexpression and ectopic expression induces mesenchymal and epithelial tumorigenesis respectively and distinguish the pathogenesis of benign from malignant mesenchymal tumors. Importantly, we highlight the regulatory role of microRNA family of tumor suppressors in determining HMGA2 misexpression events leading to tumor pathogenesis and focused on possible mechanisms by which HMGA2 could propagate lymphangioleiomyomatosis (LAM), benign mesenchymal tumors of the lungs. Read More

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http://dx.doi.org/10.3390/ijms21093151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246488PMC

Mesenteric lymphadenopathy is a key to diagnosis of radiologically challenging pulmonary lymphoma.

Thorac Cancer 2020 Jun 29;11(6):1738-1740. Epub 2020 Apr 29.

Department of Radiology, MacKay Memorial Hospital, Taipei, Taiwan.

Extranodal marginal zone B-cell lymphoma (EMZBL), previously known as mucosa-associated lymphoid tissue lymphoma, is the most common type of marginal zone B-cell lymphomas. Primary pulmonary lymphomas only constitute 0.5% of primary lung cancer, but 90% of these are EMZBLs. Read More

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http://dx.doi.org/10.1111/1759-7714.13453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262911PMC

Tuberous sclerosis complex associated intracranial lesion found by antenatal ultrasound.

Radiol Case Rep 2020 Jul 22;15(7):816-818. Epub 2020 Apr 22.

Division of Neurology, Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada.

Tuberous sclerosis complex (TSC) is characterized by the growth of benign tumors in the skin, brain, kidneys, lung and heart [1]. Prognosis is mostly determined by the extent of brain involvement as tumors in the brain lead to seizures, cognitive impairment and behavioral problems. Current evidence suggests anti-epileptic treatment before the onset of seizures reduces epilepsy severity and risk of cognitive impairment in TSC however identifying these children prior to the onset of seizures is challenging. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182691PMC

Systematic review of observational studies reporting antiphospholipid antibodies in patients with solid tumors.

Blood Adv 2020 Apr;4(8):1746-1755

Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

This review summarizes the evidence on antiphospholipid (aPL) antibodies and related thromboembolic events in patients with solid tumors. Data sources included Medline, EMBASE, Web of Science, PubMed ePubs, and the Cochrane Central Register of Controlled Trials through August 2019 without restrictions. Observational studies that evaluated patients with solid tumors for the presence of aPL antibodies were included. Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189282PMC

Prospective Evaluation of the NETest as a Liquid Biopsy for Gastroenteropancreatic and Bronchopulmonary Neuroendocrine Tumours: An ENETS Centre of Excellence Experience.

Neuroendocrinology 2020 Apr 24. Epub 2020 Apr 24.

Background: There is a substantial unmet clinical need for an accurate and effective blood biomarker for neuroendocrine neoplasms (NEN). We therefore evaluated, under real-world conditions, the clinical utility of the NETest as a liquid biopsy in an ENETS Centre of Excellence and compared its utility with chromogranin A (CgA). Methods Cohorts: Gastroenteropancreatic (GEP)-NEN (n=253), bronchopulmonary (BP)-NEN (n=64), thymic NEN (n=1), colon cancer (n=37), NSCLC (n=63), benign lung disease (n=59) and controls (n=86). Read More

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http://dx.doi.org/10.1159/000508106DOI Listing

[The Role of Plasma CDO1 Methylation in the Early Diagnosis of Lung Cancer].

Zhongguo Fei Ai Za Zhi 2020 May 22;23(5):314-320. Epub 2020 Apr 22.

Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.

Background: The incidence and mortality of lung cancer often rank first in all malignant tumors. DNA methylation, as one of epigenetics, often participates in the development and progression of tumors. CDO1 as a tumor suppressor gene always undergoes methylation changes early in tumor development. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2020.102.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260387PMC

Clinical significance of serum neuron-specific enolase in gastric adenocarcinoma.

Medicine (Baltimore) 2020 Apr;99(16):e19829

China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.

As a biomarker, neuron-specific enolase (NSE) has been widely recognized in the diagnosis of benign diseases and malignant tumors. This study aimed to investigate the potential diagnostic value of NSE in patients with gastric adenocarcinoma.Serum levels of the NSE were compared between 219 patients with gastric adenocarcinoma and 298 healthy individuals, NSE and clinicopathological parameters were analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000019829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220193PMC

[Analysis of robotic natural orifice specimen extraction surgery on 162 cases with rectal neoplasms].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Apr;23(4):384-389

Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, China.

To explore the safety and feasibility of da Vinci robot surgical systems in natural orifice specimen extraction surgery (NOSES) for rectal neoplasms. A descriptive cohort study was used. Inclusion criteria: (1) age ≥18 years old; (2) diagnosis of rectal cancer by biopsy via colonoscopy or benign neoplasm locating in rectum that could not be resected locally through the anus; (3) R0 resection can be achieved by preoperative evaluation; (4) the CDmax (maximum circumferential diameter) was ≤5 cm or specimens could still be extracted from the anus despite a CDmax exceeding 5 cm but was along the longitudinal axis of the rectum. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20191017-00453DOI Listing

[A rare case of cystadenoma in the small intestine].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):382-384

Department of Oncology, Hebei Hosptical of Traditional Chinese Medicine Affiliated to Hebei University of Traditional Chinese Medicine, Shijiazhuang 050011, China.

In recent years, there have been more and more reports about cystadenoma. Cystadenoma can occur in many parts of the body, and cystadenoma in different parts may show different clinical symptoms, however, some patients with cystadenoma have no symptoms. The vast majority of cystadenomas are benign lesions, but a small number of cystadenomas can be malignant. Read More

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Diagnosis of neurofibromatosis type 1 after rupture of aneurysm and consequent fatal hemothorax.

Am J Emerg Med 2020 Apr 7. Epub 2020 Apr 7.

Department of Emergency and Disaster Medicine, Showa University, Fujigaoka Hospital, 1-30 Fujigaoka Aoba-ku, Yokohama 227-8501, Japan; Department of Emergency and Disaster Medicine, Showa University, 1-5-8 Hatanodai Shinagawa-ku, Tokyo 142-8666, Japan.

Patients with neurofibromatosis type 1 (NF1) can develop both benign and malignant tumors throughout their lives. A 49-year-old man was transferred to the emergency department with complaints of sudden right dorsal pain and respiratory discomfort. He was in shock on arrival. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.04.004DOI Listing

What Factors Are Associated with Treatment Outcomes of Japanese Patients with Clear Cell Chondrosarcoma?

Clin Orthop Relat Res 2020 Apr 14. Epub 2020 Apr 14.

R. Nakayama, N. Asano, Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan K. Hayakawa, Department of Orthopaedic Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan E. Kobayashi, Division of Musculoskeletal Oncology and Rehabilitation, National Cancer Center Hospital, Tokyo, Japan M. Endo, Department of Orthopaedic Surgery, Kyushu University, Fukuoka, Japan T. Yonemoto, Department of Orthopaedic Surgery, Chiba Cancer Center, Chiba, Japan H. Kawashima, Department of Orthopaedic Surgery, Niigata University, Niigata, Japan K. Hamada, Department of Orthopaedic Surgery, Osaka University, Osaka, Japan I. Watanabe, Department of Orthopaedic Surgery, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan H. Futani, Department of Orthopaedic Surgery, Hyogo College of Medicine T. Goto, Department of Musculoskeletal Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital Y. Nishida, Department of Rehabilitation Medicine, Nagoya University, Aichi, Japan T. Ozaki, Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Okayama, Japan.

Background: Clear cell chondrosarcoma is an extremely rare chondrosarcoma subtype; thus, its treatment outcomes and associated factors have not been widely studied. Knowing more about it is potentially important because clear cell chondrosarcomas are often misdiagnosed as other benign lesions and subsequently treated and followed inappropriately.

Questions/purposes: (1) What are the patient- and tumor-related characteristics of clear cell chondrosarcoma? (2) What proportion of patients with clear cell chondrosarcoma initially had a misdiagnosis or a misleading initial biopsy result? (3) What is the survivorship of patients with clear cell chondrosarcoma free from death, local recurrence, and distant metastasis, and what factors are associated with greater survivorship or a reduced risk of local recurrence?

Methods: Between 1985 and 2018, 12 Japanese Musculoskeletal Oncology Group (JMOG) hospitals treated 42 patients with a diagnosis of clear cell chondrosarcoma. Read More

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http://dx.doi.org/10.1097/CORR.0000000000001266DOI Listing

Predictive model for the diagnosis of benign/malignant small pulmonary nodules.

Medicine (Baltimore) 2020 Apr;99(15):e19452

Taizhou First People's Hospital, Taizhou, Zhejiang, China.

There is some doubt that all nodules <8 mm are really mainly benign and that simple follow-up is adequate in all cases. The purpose of this study is to create a predictive model for the diagnosis of benign and malignant small pulmonary nodules.This was a retrospective case-control study of patients who had undergone pulmonary nodule resection at the Zhejiang University Jinhua Hospital. Read More

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http://dx.doi.org/10.1097/MD.0000000000019452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220466PMC

New Developments in the Pathogenesis of Pulmonary Cysts in Birt-Hogg-Dubé Syndrome.

Semin Respir Crit Care Med 2020 Apr 12;41(2):247-255. Epub 2020 Apr 12.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant disorder caused by germline loss-of-function mutations in gene (FLCN). BHD is characterized by lower lobe-predominant pulmonary cysts with risk of pneumothorax, benign skin tumors (fibrofolliculomas), and renal cell carcinoma, often of an unusual chromophobe/oncocytic hybrid histology. The FLCN protein functions in multiple signaling and metabolic pathways including positive regulation of mechanistic target of rapamycin complex 1 (mTORC1) activity via FLCN's GTPase (GAP) activity for Rag C, positive regulation of Wnt signaling (in mesenchymal cells), and negative regulation of TFE3 nuclear localization. Read More

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http://dx.doi.org/10.1055/s-0040-1708500DOI Listing

<Editors' Choice> mRNA expression in soft-tissue tumors.

Nagoya J Med Sci 2020 Feb;82(1):85-92

Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Stanniocalcin-1 () is a glycoprotein that was originally identified as a calcium-regulating hormone in bony fish, and that has been shown to also critically mediate cell growth, proliferation and differentiation, etc. in humans. Increased expression levels have been previously detected in different human cancer samples, such as those isolated from lung, breast, ovary, colon, pancreas, and liver tumors; thus, the present study evaluated expression in various soft-tissue tumors. Read More

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http://dx.doi.org/10.18999/nagjms.82.1.85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103862PMC
February 2020

Tumor-to-Tumor Metastasis of Multiple Meningiomas and Clear Cell Renal Cell Carcinoma Metastasis as First Clinical Appearance of Kidney Cancer: A Case Report and Analysis.

J Neurol Surg Rep 2020 Jan 31;81(1):e10-e14. Epub 2020 Mar 31.

Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany.

 Meningioma accounts for more than 35% of all diagnosed brain tumors of the central nervous system and, moreover, it is the most common benign recipient of tumor-to-tumor metastasis. Several cases with tumor-to-meningioma metastasis by breast, lung, and intestinal cancer have been described before.  The case of a patient with a longstanding history of multiple meningiomas (  = 4) that suddenly became symptomatic and progressive in size is presented. Read More

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http://dx.doi.org/10.1055/s-0040-1708846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108953PMC
January 2020

Diagnostic Yield of Computed Tomography-Guided Percutaneous Lung Biopsy in Patients With Prior Nondiagnostic Transbronchial Biopsy.

J Comput Assist Tomogr 2020 Mar/Apr;44(2):305-309

Department of Radiology, Xuzhou Central Hospital, Xuzhou, China.

Purpose: The purpose of this study was to assess the diagnostic yield of computed tomography (CT)-guided core needle biopsy (CNB) for initial transbronchial biopsy (TBB)-based nondiagnostic lung lesions.

Methods: From January 2014 to December 2017, 101 consecutive patients with initial TBB-based nondiagnostic lung lesions underwent CT-guided CNB. All procedures were performed with an 18G core needle by a chest radiologist with more than 5 years of experience. Read More

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http://dx.doi.org/10.1097/RCT.0000000000000999DOI Listing

Robotic Thoracic Surgery.

Surg Clin North Am 2020 Apr 6;100(2):237-248. Epub 2020 Feb 6.

Yale School of Medicine, Lauder Hall, 310 Cedar Street, New Haven, CT 06510, USA.

Minimally invasive surgery for diseases of the chest offsets the morbidity of painful thoracic incisions while allowing for meticulous dissection of major anatomic structures. This benefit translates to improved outcomes and recovery following the surgical management of benign and malignant esophageal pathologic condition, mediastinal tumors, and lung resections. This anatomic region is particularly amenable to a robotic approach given the fixed space and need for complex intracorporeal dissection. Read More

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http://dx.doi.org/10.1016/j.suc.2019.12.001DOI Listing

Utility of isocitrate dehydrogenase 1 as a serum protein biomarker for the early detection of non-small-cell lung cancer: A multicenter in vitro diagnostic clinical trial.

Cancer Sci 2020 May 5;111(5):1739-1749. Epub 2020 May 5.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

We aimed to verify the expression status and diagnostic significance of isocitrate dehydrogenase 1 (IDH1) in non-small-cell lung cancer (NSCLC), especially during early stages. Serum IDH1 levels were measured by ELISA. A total of 1223 participants (660 patients with NSCLC, 276 healthy controls [HCs], 95 patients with benign pulmonary conditions [BPCs], 135 patients with other cancers [OCs], and 57 samples with interfering factors) were divided into a training cohort and a validation cohort according to 3 testing centers. Read More

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http://dx.doi.org/10.1111/cas.14387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226212PMC

The value of diffusion-weighted imaging based on monoexponential and biexponential models for the diagnosis of benign and malignant lung nodules and masses.

Br J Radiol 2020 Jun 25;93(1110):20190400. Epub 2020 Mar 25.

Department of Radiology, Yancheng City No.1 People's Hospital, Yancheng, China.

Objectives: The objective is to compare the efficacy of diffusion-weighted imaging (DWI) parameters of mean and minimum apparent diffusion coefficient (ADC and ADC) and intravoxel incoherent motion (IVIM) in the differentiation of benign and malignant lung nodules and masses.

Methods: Lung lesions measured larger than 1.5 cm on CT were included between August 2015 and September 2018. Read More

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http://dx.doi.org/10.1259/bjr.20190400DOI Listing

Endobronchial Glomus Tumor in a Child.

Pediatr Allergy Immunol Pulmonol 2019 Dec 11;32(4):163-166. Epub 2019 Dec 11.

Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri.

Glomus tumors (GTs) are rare, usually benign, mesenchymal neoplasms typically located in the cutaneous tissues of the extremities. Visceral locations have been reported in ∼5% of cases. The average age at diagnosis is 42 years. Read More

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http://dx.doi.org/10.1089/ped.2019.1065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057049PMC
December 2019

Pulmonary adenomyoma presenting as a right cardiophrenic angle mass.

Radiol Case Rep 2020 May 26;15(5):502-506. Epub 2020 Feb 26.

Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.

Pulmonary adenomyomas are rare adenomyomatous hamartomas. In the few cases described in the literature, these benign tumors are encapsulated by lung parenchyma. We describe a case of a 59 year-old woman with acetylcholine receptor antibody-negative myasthenia gravis and a right cardiophrenic mass initially thought to be a thymoma. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044680PMC

Deep learning approach to classification of lung cytological images: Two-step training using actual and synthesized images by progressive growing of generative adversarial networks.

PLoS One 2020 5;15(3):e0229951. Epub 2020 Mar 5.

Department of Electrical, Electronic and Computer Engineering, Faculty of Engineering, Gifu University, Gifu, Japan.

Cytology is the first pathological examination performed in the diagnosis of lung cancer. In our previous study, we introduced a deep convolutional neural network (DCNN) to automatically classify cytological images as images with benign or malignant features and achieved an accuracy of 81.0%. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229951PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058306PMC

Preoperative diagnosis of malignant pulmonary nodules in lung cancer screening with a radiomics nomogram.

Cancer Commun (Lond) 2020 Jan 3;40(1):16-24. Epub 2020 Mar 3.

Department of Biostatistics, School of Public Health, Shandong University, Jinan, Shandong, 250002, P. R. China.

Background: Lung cancer is the most commonly diagnosed cancer worldwide. Its survival rate can be significantly improved by early screening. Biomarkers based on radiomics features have been found to provide important physiological information on tumors and considered as having the potential to be used in the early screening of lung cancer. Read More

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http://dx.doi.org/10.1002/cac2.12002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163925PMC
January 2020

Long non-coding RNA MALAT1 as a key target in pathogenesis of glioblastoma. Janus faces or Achilles' heal?

Gene 2020 May 28;739:144518. Epub 2020 Feb 28.

Department of Biochemistry, Acibadem University, Istanbul, Turkey; Department of Psychiatry, Maastricht University, Netherlands. Electronic address:

Glioblastomas (GBMs) are primary brain tumors with extremely bad prognosis and therefore; discovery of novel regulators of their pathology is of immense importance. LncRNAs (long noncoding RNAs) regulate nuclear structure, embryonic pluripotency, cell differentiation, development and carcinogenesis. Many lncRNAs have weak evolutionary conservation; however, a nuclear lncRNA, MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), is exceptionally conserved and is among the most abundant lncRNAs in benign tissues. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144518DOI Listing