10,333 results match your criteria Benign Lung Tumors

Neurofibromatosis from Head to Toe: What the Radiologist Needs to Know.

Radiographics 2022 Jun 24:210235. Epub 2022 Jun 24.

From the Department of Radiology (M.X.W., C.T.J., K.M.E.) and Department of Lymphoma and Myeloma (S.K.), University of Texas MD Anderson Cancer Center, Pickens Academic Tower, 1400 Pressler St, Houston, TX 77030-4009; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio (J.R.D.); Department of Radiology, Stanford University, Stanford, Calif (J.G.); Department of Radiology (A.H.) and Faculty of Medicine (M.M.), Alexandria University, Alexandria, Egypt; and Department of Radiology, Mayo Clinic Arizona, Phoenix/Scottsdale, Ariz (P.M.P.).

Neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2) are autosomal dominant inherited neurocutaneous disorders or phakomatoses secondary to mutations in the and tumor suppressor genes, respectively. Although they share a common name, NF1 and NF2 are distinct disorders with a wide range of multisystem manifestations that include benign and malignant tumors. Imaging plays an essential role in diagnosis, surveillance, and management of individuals with NF1 and NF2. Read More

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Heavy-Ion-Induced Lung Tumors: Dose- & LET-Dependence.

Life (Basel) 2022 Jun 17;12(6). Epub 2022 Jun 17.

Biological Systems & Engineering Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA.

There is a limited published literature reporting dose-dependent data for in vivo tumorigenesis prevalence in different organs of various rodent models after exposure to low, single doses of charged particle beams. The goal of this study is to reduce uncertainties in estimating particle-radiation-induced risk of lung tumorigenesis for manned travel into deep space by improving our understanding of the high-LET-dependent dose-response from exposure to individual ion beams after low particle doses (0.03-0. Read More

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Development and validation of reassigned CEA, CYFRA21-1 and NSE-based models for lung cancer diagnosis and prognosis prediction.

BMC Cancer 2022 Jun 22;22(1):686. Epub 2022 Jun 22.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi Province, China.

Background: The majority of lung cancer(LC) patients are diagnosed at advanced stage with a poor prognosis. However, there is still no ideal diagnostic and prognostic prediction model for lung cancer.

Methods: Data of CEA, CYFRA21-1 and NSE test of patients with LC and benign lung diseases (BLDs) or healthy people from Physical Examination Center was collected. Read More

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Up-regulation of POM121 is linked to prostate cancer aggressiveness and serves as a prognostic biomarker.

Urol Oncol 2022 Jun 17. Epub 2022 Jun 17.

Pathology of the University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany, Luebeck, Germany; Research Center Borstel, Leibniz Lung Center, Borstel, Germany, Borstel Germany. Electronic address:

Purpose: Nucleoporins as components of the nuclear pore complex (NCP) are known for regulating nuclear-cytoplasmatic transport. Recently, the nucleoporin POM121 was found to have an important impact on intranuclear translocation of prostate cancer (PCa)-specific tumor drivers including the androgen receptor (AR). The aim of our study was to assess the potential of POM121 as a prognostic biomarker. Read More

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PET-CTBased Quantitative Parameters for Assessment of Treatment Response and Disease Activity in Cancer and Noncancerous Disorders.

PET Clin 2022 Jul;17(3):465-478

Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Parel, Mumbai, India; Homi Bhabha National Institute, Mumbai, India. Electronic address:

The various semiquantitative and quantitative PET-CT parameters provide measurement of disease activity and assessment of treatment response in the PET-CT studies. These include standardized uptake value (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), and total metabolic tumor volume (TMTV). Thresholding and adaptive thresholding methods are commonly used algorithms for the evaluation of global disease activity. Read More

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Serum Extracellular Nano-Vesicles miR-153-3p to Identify Micronodular Lung Cancer from Sub-Centimeter Lung Nodules.

J Biomed Nanotechnol 2022 Mar;18(3):705-717

Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, P. R. China.

Identification of malignancy from sub-centimeter lung nodules (LNs, <1 cm) is core for prevention and treatment of primary phases of lung cancer (LC). The study's purpose was to predict micro-nodular lung cancer (mnLC), such as adenocarcinoma (AIS), micro-invasive adenocarcinoma (MIA), and invasive adenocarcinoma stage 1 (IA) based on serum extracellular nano-vesicles (sEVs) miR-153-3p. sEVs-miR-153-3p was selected in this study and then used to investigate the expression and efficacy by RT-qPCR in the validation phase, followed by sEVs derived from patients of mnLC, benign lung nodule (BLN), and healthy people groups comprised of 135 recruiters. Read More

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Natural history of gastrointestinal schwannomas.

Endosc Int Open 2022 Jun 10;10(6):E801-E808. Epub 2022 Jun 10.

Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute; Cleveland Clinic, Cleveland, Ohio, United States.

Data are lacking on the natural history of gastrointestinal tract schwannomas. We aimed to study the natural history of all gastrointestinal schwannomas including location, diagnosis, management, and long-term outcomes. Patients with a pathological diagnosis of gastrointestinal schwannoma between January 2000 and March 2020 were identified. Read More

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Pearls and Pitfalls in Lung Cancer CT Screening.

Semin Ultrasound CT MR 2022 Jun 12;43(3):246-256. Epub 2022 Mar 12.

Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

Annual LDCT lung cancer screening is recommended by the United States Preventive Services Task Force (USPSTF) for high-risk population based on the results from the National Lung Cancer Screening Trial (NLST) that showed a significant (20%) reduction in lung cancer-specific mortality rate with the use of annual low-dose computed tomography (LDCT) screening. More recently, the benefits of lung cancer screening were confirmed by the Dutch- Belgian NELSON trial in Europe. With the implementation of lung screening in large scale, knowledge of the limitations related to false positive, false negative and other potential pitfalls is essential to avoid misdiagnosis. Read More

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Solitary Pulmonary Nodule Evaluation: Pearls and Pitfalls.

Semin Ultrasound CT MR 2022 Jun 5;43(3):230-245. Epub 2022 Feb 5.

Department of Radiology, NYU Langone Health, NYU Grossman School of Medicine, New York, NY.

Lung nodules are frequently encountered while interpreting chest CTs and are challenging to detect, characterize, and manage given they can represent both benign or malignant etiologies. An understanding of features associated with malignancy and causes of interpretive pitfalls is helpful to avoid misdiagnoses. This review addresses pertinent topics related to the etiologies for missed lung nodules on radiography and CT. Read More

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Pulmonary Nodule Clinical Trial Data Collection and Intelligent Differential Diagnosis for Medical Internet of Things.

Contrast Media Mol Imaging 2022 26;2022:2058284. Epub 2022 May 26.

Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.

In this paper, the medical Internet of things (IoT) is used to pool data from clinical trials of pulmonary nodules, and on this basis, intelligent differential diagnosis techniques are investigated. A filtered orthogonal frequency division multiplexing model based on polarisation coding is proposed, where the input data are fed to a modulator after polarisation cascade coding, and the system performance is analysed under a medical Internet of things modulated additive Gaussian white noise channel. The above polarisation-coded filtered orthogonal frequency division multiplexing system components are applied to electroencephalogram (EEG) signal transmission, to which a threshold compression module and a vector reconstruction module are added to address the system power burden associated with the acquisition and transmission of large amounts of real-time EEG data in the medical IoT. Read More

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Diagnostic Value of Emission Computed Tomography Combined with Computed Tomography for Metastatic Malignant Tumor of Spine.

Contrast Media Mol Imaging 2022 26;2022:5847589. Epub 2022 May 26.

Department of Spinal Surgery, Dongying Shengli Oilfield Central Hospital, Dongying City 257100, Shandong Province, China.

Objective: To explore the diagnostic value of emission computed tomography (ECT) combined with computed tomography (CT) for metastatic malignant tumor of spine.

Methods: By means of retrospective study, a total of 102 patients with extraskeletal primary malignant tumor treated in our hospital from February 2019 to February 2021 were selected as the subjects. All patients had single lesion of the spine, of which 72 were malignant and 30 were benign according to the results of pathological examination. Read More

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[Progressive massive fibrosis in pneumoconiosis is mimicking lung malignancy on (18)F-FDGPET-CT: two cases report].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2022 May;40(5):378-380

Wuxi People's Hospital Affiliated to Nanjing Medical University, Department of Thoracic Surgery, Wuxi 214023, China.

Occupational pneumoconiosis is one of the main occupational diseases in China. Progressive massive fibrosis in pneumoconiosis should be distinguished from lung cancer for their similar imaging features which is often identified by (18)F-FDG PET-CT in clinic. Here we reported two cases of pneumoconiosis. Read More

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Extramedullary hematopoiesis in an inguinal lymph node: an unusual presentation of primary myelofibrosis.

World J Surg Oncol 2022 Jun 8;20(1):186. Epub 2022 Jun 8.

Department of Histopathology, Indus Hospital and Health Network, Karachi, 75190, Pakistan.

Background: Extramedullary hematopoiesis (EMH) is a proliferation of hematopoietic tissue outside of the bone marrow medullary space. It is a pathophysiologic response, more often associated with either a benign reactive hematological disease or a myeloproliferative neoplasm (MPN). Identification of EMH in adults is always pathologic. Read More

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Diagnostic difficulties in giant benign phyllodes tumor.

Rom J Morphol Embryol 2021 Oct-Dec;62(4):1035-1044

Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania;

Phyllodes tumors (PTs) are rare tumors of the breast, which encompass both stromal and epithelial components. The maximum incidence is in the fourth decade of life. Most of these tumors are benign, but about one third can be malignant acting as sarcomas. Read More

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Role of Neuron-Specific Enolase in the Diagnosis and Disease Monitoring of Sarcoidosis.

Can Respir J 2022 26;2022:3726395. Epub 2022 May 26.

Gunma University Graduate School of Health Sciences, Maebashi, Japan.

Sarcoidosis is a systemic granulomatous disease of unknown etiology. The diagnosis of sarcoidosis is based on clinicopathologic findings accompanied by the formation of granulomas in multiple organs, including the lung. Although angiotensin-converting enzyme (ACE) and soluble interleukin 2 receptor (sIL-2R) are traditionally used for the diagnosis of sarcoidosis, specific diagnostic markers remain to be determined. Read More

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Computed tomography-guided cutting needle biopsy for lung nodules: when the biopsy-based benign results are real benign.

World J Surg Oncol 2022 Jun 4;20(1):180. Epub 2022 Jun 4.

Radiology Department, Xuzhou Central Hospital, Xuzhou, China.

Background: Computed tomography (CT)-guided cutting needle biopsy (CNB) is an effective diagnostic method for lung nodules (LNs). The false-negative rate of CT-guided lung biopsy is reported to be up to 16%. This study aimed to determine the predictors of true-negative results in LNs with CNB-based benign results. Read More

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Identification and Validation of Serum CST1 as a Diagnostic Marker for Differentiating Early-Stage Non-Small Cell Lung Cancer from Pulmonary Benign Nodules.

Cancer Control 2022 Jan-Dec;29:10732748221104661

Department of Clinical Laboratory, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 71067Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: Effective means for early diagnosis are imperative to reduce death rate of non-small cell lung cancer (NSCLC) patients. We aimed to find out high-performance serologic markers to distinguish early-stage NSCLC patients from benign pulmonary nodule patients and healthy controls (HC). Cystatin-SN (CST1) is an active cysteine protease inhibitor of the CST superfamily, involving in the processes of inflammation and tumorigenesis. Read More

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DeepLN: A Multi-Task AI Tool to Predict the Imaging Characteristics, Malignancy and Pathological Subtypes in CT-Detected Pulmonary Nodules.

Front Oncol 2022 11;12:683792. Epub 2022 May 11.

Department of Respiratory and Critical Care Medicine, Med-X Center for Manufacturing, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.

Objectives: Distinction of malignant pulmonary nodules from the benign ones based on computed tomography (CT) images can be time-consuming but significant in routine clinical management. The advent of artificial intelligence (AI) has provided an opportunity to improve the accuracy of cancer risk prediction.

Methods: A total of 8950 detected pulmonary nodules with complete pathological results were retrospectively enrolled. Read More

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Mucoepidermoid carcinoma: Analysis of 76 cytologic cases and correlation with histologic grade.

Paul E Wakely

Cancer Cytopathol 2022 May 31. Epub 2022 May 31.

Department of Pathology, The Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA.

Background: Mucoepidermoid carcinoma (MEC) is the most common salivary gland (SG) malignancy. In this study, the author undertook analysis of a large collection of MEC cytologic cases.

Materials And Methods: Cytopathology files were searched for MEC cases with histopathologic confirmation. Read More

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Adenomatoid mesothelioma arising from the diaphragm: a case report and review of the literature.

J Med Case Rep 2022 May 30;16(1):228. Epub 2022 May 30.

Department of Gastroenterological Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Background: Adenomatoid mesothelioma is a rare subtype of malignant mesothelioma that can be confused with adenomatoid tumors, which are classified as benign. The clinical features and optimal management of adenomatoid mesothelioma have not been elucidated in the literature. In this report, we present an extremely rare case of adenomatoid mesothelioma that developed on the peritoneal surface of the diaphragm as well as a literature review of adenomatoid mesothelioma in the abdominal cavity. Read More

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Hamartochondroma Pleural Lesion Mimicking Liposarcoma: A Case Report.

Curr Oncol 2022 05 11;29(5):3489-3493. Epub 2022 May 11.

Department of Thoracic Surgery and Lung Transplantation, Louis Pradel Hospital, Hospices Civils de Lyon, 69677 Bron, France.

Heterogeneous masses developing in the pleural cavity are most often malignant and can pose diagnostic challenges. Fibrous tumors of the pleura, liposarcoma, thymoma or lipoma most frequently affect this anatomic area. Surgical exploration and resection are often mandatory to make the definitive diagnosis. Read More

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A case of recurrent pneumothorax and skin lesions diagnosed with Birt-Hogg-Dubé.

Oxf Med Case Reports 2022 May 23;2022(5):omac054. Epub 2022 May 23.

Department of Internal Medicine (Pulmonary Division), School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant disease that is manifested as benign cutaneous tumors, multiple lung parenchymal cysts and an increased risk of renal cancer. Its symptoms usually do not appear until adulthood. We report a patient who was admitted with recurrent pneumothorax. Read More

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[Pulmonary Hematoma Likely due to a Contralateral Chest Injury, Requiring Differentiation from Lung Tumor:Report of a Case].

Kyobu Geka 2022 Jun;75(6):476-479

Department of Thoracic Surgery, Sapporo Minami-Sanjo Hospital, Sapporo, Japan.

A 23-year-old man was referred to our department for chest abnormal shadow. Computed tomography (CT) of the chest revealed a well-defined 1.2 cm nodule in the S4 segment of the right middle lobe and a well-defined 1. Read More

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The value of radiomics based on dual-energy CT for differentiating benign from malignant solitary pulmonary nodules.

BMC Med Imaging 2022 May 21;22(1):95. Epub 2022 May 21.

Toxicology Department, WestChina-Frontier PharmaTech Co., Ltd. (WCFP), Chengdu, 610075, China.

Objective: To investigate the value of monochromatic dual-energy CT (DECT) images based on radiomics in differentiating benign from malignant solitary pulmonary nodules.

Materials And Methods: This retrospective study was approved by the institutional review board, and informed consent was waived. Pathologically confirmed lung nodules smaller than 3 cm with integrated arterial phase and venous phase (AP and VP) gemstone spectral imaging were retrospectively identified. Read More

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[Bronchoscopic treatment of malignant central airway obstruction: A cohort study, long-term survival and complications].

R Elleuch

Rev Mal Respir 2022 May 16. Epub 2022 May 16.

Avenue de la Liberté, rue Ahmed Aloulou, immeuble Fairouz, 3027 Sfax, Tunisie. Electronic address:

Introduction: Interventional bronchoscopy is now the standard treatment for tracheobronchial narrowing due to tumor. The objective of our study was to analyze long-term survival and complications occurring in patients with malignant airway obstruction.

Methods: We retrospectively studied the data from 93 patients treated between 2008 and 2019. Read More

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ROS1-positive Inflammatory Myofibroblastic Tumor of the Small Bowel Causing Obstruction: A Case Report.

J Radiol Case Rep 2022 Jan 1;16(1):14-21. Epub 2022 Jan 1.

The Institute of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Inflammatory Myofibroblastic Tumors (IMTs) are rare fibroblastic/myofibroblastic neoplasms that affect predominately pediatric patients and young adults. Almost half of the patients with IMTs have a chromosomal abnormality in the Anaplastic Lymphoma Kinase 1 gene on chromosome 2p23. Although these tumors occur primarily in the lung, lesions have been reported in a variety of intra-abdominal organs like the liver, spleen, and mesentery. Read More

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January 2022

Endobronchial ultrasound-guided transbronchial needle aspiration facilitating diagnosis of sarcoidosis in a breast cancer patient with multiple lymphadenopathy: a case report.

J Med Case Rep 2022 May 19;16(1):194. Epub 2022 May 19.

Suzugamine Imanaka Clinic, 4-2-31, Inokuchi, Nishi-ku, Hatsukaichi, Hiroshima, Hiroshima, 733-0842, Japan.

Background: Sarcoidosis is a benign systemic granulomatous disorder of unknown etiology. Cell-mediated immunity disorder is often found in sarcoidosis patients, and an association between malignant tumors and sarcoidosis has been suggested. Sarcoidosis and malignant disease can occur simultaneously or sequentially, leading to misdiagnosis and mistreatment. Read More

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Soluble HLA peptidome of pleural effusions is a valuable source for tumor antigens.

J Immunother Cancer 2022 05;10(5)

Institute of Pulmonary Medicine, Chaim Sheba Medical Center, Ramat Gan, Israel

Background: Soluble human leucocyte antigen (sHLA) molecules, released into the plasma, carry their original peptide cargo and provide insight into the protein synthesis and degradation schemes of their source cells and tissues. Other body fluids, such as pleural effusions, may also contain sHLA-peptide complexes, and can potentially serve as a source of tumor antigens since these fluids are drained from the tumor microenvironment. We explored this possibility by developing a methodology for purifying and analyzing large pleural effusion sHLA class I peptidomes of patients with malignancies or benign diseases. Read More

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Primary Mediastinal Large B-Cell Lymphoma Achieved by Non-Cautery Assisted Transbronchial Mediastinal Cryobiopsy.

Respiration 2022 May 16:1-5. Epub 2022 May 16.

Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China.

Transbronchial mediastinal cryobiopsy is a novel sampling strategy that shows improved diagnostic utility for mediastinal lesions, particularly in rare tumors and benign disorders, as compared to standard endobronchial ultrasound-guided transbronchial needle aspiration. During this procedure, electrocautery incision is frequently needed to advance the cryoprobe through the airway into the mediastinal lesion, which however results in increased operative difficulty and prolonged procedural time. Here we present a case of mediastinal large B-cell lymphoma successfully diagnosed by transbronchial mediastinal cryobiopsy without cautery-induced airway incision. Read More

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Endobronchial lipoma.

Autops Case Rep 2022 2;12:e2021377. Epub 2022 May 2.

Augusta University, Medical College of Georgia, Augusta, Georgia, USA.

Endobronchial lipomas are rare benign lung tumors that can cause bronchial obstruction and parenchymal damage. While an uncommon etiology, they are often misdiagnosed due to a clinical presentation similar to obstructive pulmonary pathologies such as COPD and asthma. Upon review of English-language literature, under 50 cases of endobronchial lipomas were documented in the prior 10 years (2011-2021). Read More

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