8,931 results match your criteria Benign Lung Tumors


Increased Risk of Lung Metastases in Patients with Giant Cell Bone Tumors: A Systematic Review.

Authors:
Josef Yayan

Adv Exp Med Biol 2019 Apr 16. Epub 2019 Apr 16.

Department of Internal Medicine, Division of Pulmonary, Allergy and Sleep Medicine, HELIOS Clinic Wuppertal, Witten/Herdecke University, Witten, Germany.

Giant cell tumors of the bone are rare, usually benign, tumors consisting of large, multinucleated bone cells. Remarkably, these tumors are characterized by aggressive growth. They tend to recur frequently and, in rare cases, metastasize to the lungs. Read More

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http://dx.doi.org/10.1007/5584_2019_372DOI Listing
April 2019
1 Read

Benign metastasizing leiomyoma presenting with miliary pattern and fatal outcome: Case report with molecular analysis & review of the literature.

Respir Med Case Rep 2019 28;27:100831. Epub 2019 Mar 28.

Department of Pathology and Cell Biology, Columbia University Medical Center, New York, USA.

Benign metastasizing leiomyoma (BML) is a rare benign smooth muscle neoplasm that originates in the uterus and metastasizes to distant sites-most commonly the lungs. BMLs are often found incidentally in patients with a history of uterine leiomyoma(s) and tend to be indolent. Occasionally they may be symptomatic and rarely follow an aggressive clinical course. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.100831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446132PMC
March 2019
1 Read

Rare Lung Tumors: Alveolar Adenoma-Four Case Reports.

Turk Thorac J 2019 Apr 1. Epub 2019 Apr 1.

Clinic of Thoracic Surgery, University of Heath Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey.

Alveolar adenoma is one of the rarely seen benign tumors of the lung, to date, one or two series have been reported. In this study, four rare alveolar adenoma cases were presented, thereby contributing to the existing scarce data. Read More

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http://turkthoracj.org/eng/makale/1104/154/Full-Text
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http://dx.doi.org/10.5152/TurkThoracJ.2018.18015DOI Listing
April 2019
1 Read

Metastases to the breast, an uncommon diagnosis: what do radiologists need to know?

Radiologia 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Anatomía Patológica, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Objective: To analyze the imaging characteristics of histologically diagnosed metastases to the breast.

Material And Methods: We selected patients histologically diagnosed with metastases to the breast in our diagnostic and interventional breast imaging unit between March 2010 and September 2018.

Results: A total of 9 patients (all women; mean age, 60 y; age range, 28-89 y) were diagnosed with metastases to the breast. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00338338193003
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http://dx.doi.org/10.1016/j.rx.2019.02.004DOI Listing
April 2019
2 Reads

Epigenetic Classifiers for Precision Diagnosis of Brain Tumors.

Epigenet Insights 2019 31;12:2516865719840284. Epub 2019 Mar 31.

Cancer Epigenetics Laboratory, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.

DNA methylation profiling has proven to be a powerful analytical tool, which can accurately identify the tissue of origin of a wide range of benign and malignant neoplasms. Using microarray-based profiling and supervised machine learning algorithms, we and other groups have recently unraveled DNA methylation signatures capable of aiding the histomolecular diagnosis of different tumor types. We have explored the methylomes of metastatic brain tumors from patients with lung cancer, breast cancer, and cutaneous melanoma and primary brain neoplasms to build epigenetic classifiers. Read More

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http://dx.doi.org/10.1177/2516865719840284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444760PMC
March 2019
1 Read

Benign disease prone to be misdiagnosed as malignant pulmonary nodules: Minute meningothelioid nodules.

Thorac Cancer 2019 Apr 9. Epub 2019 Apr 9.

Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China.

Background: The lung is one of the most common target organs for malignant tumor metastasis. The existence of lung metastasis may have a decisive effect on the choice of treatment regimen. Minute pulmonary meningothelial-like nodules (MPMNs) usually present as ground-glass opacity or solid nodules, mimicking the imaging findings of malignant pulmonary nodules. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1759-7714.13
Publisher Site
http://dx.doi.org/10.1111/1759-7714.13061DOI Listing
April 2019
3 Reads

Clock genes and cancer development in particular in endocrine tissues.

Endocr Relat Cancer 2019 Apr 1. Epub 2019 Apr 1.

G Chrousos, Pediatrics, National and Kapodistrian University of Athens - Faculty of Medicine, Athens, Greece.

Circadian rhythms in central and peripheral level are operated by transcriptional/translational feedback loops involving a set of genes called 'clock genes' that are implicated in the development of several diseases including malignancies. Dysregulation of Clock system can affect cancer susceptibility by regulating DNA damage and repair mechanisms as well as apoptosis. A number of oncogenic pathways can be dysregulated via clock genes' epigenetic alterations including hypermethylation of clock genes' promoters or variants of clock genes. Read More

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http://dx.doi.org/10.1530/ERC-19-0094DOI Listing
April 2019
2 Reads

Amyloidosis secondary to intrapulmonary Castleman disease mimicking pulmonary hyalinizing granuloma-like clinical features: A rare case report.

Medicine (Baltimore) 2019 Apr;98(14):e15039

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Rationale: Amyloidosis secondary to intrapulmonary Castleman disease (CD) is a rare benign disease diagnosed by histopathology. It seems to be associated with chronic inflammation, and large amounts of IL-6 produced in the germinal center of CD may enhance the production of precursor of amyloid.

Patient Concerns: We reported a case of an 18-year-old woman presenting with dry cough and dyspnea on exertion for 6 months and detailed exams revealed multiple pulmonary nodules, positive antinuclear antibodies, hypocomplementemia, and thrombocytopenia. Read More

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http://dx.doi.org/10.1097/MD.0000000000015039DOI Listing
April 2019
2 Reads

Diagnostic value of soluble mesothelin-related peptides in pleural effusion for malignant pleural mesothelioma: An updated meta-analysis.

Medicine (Baltimore) 2019 Apr;98(14):e14979

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Background: Soluble mesothelin-related peptide (SMRP) is a widely studied tumor marker for diagnosing malignant pleural mesothelioma (MPM). This study discussed the diagnostic value of SMRPs in pleural effusion (PE) for MPM.

Methods: Medline, Embase, Web of Science, and Cochrane library system were systematically searched on the data of SMRPs in PE for MPM diagnosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014979DOI Listing
April 2019
1 Read
5.723 Impact Factor

Post-imaging pulmonary nodule mathematical prediction models: are they clinically relevant?

Eur Radiol 2019 Apr 1. Epub 2019 Apr 1.

Department of Radiology, University of Iowa, 200 Hawkins Drive cc704 GH, Iowa City, IA, 52242, USA.

Objectives: Post-imaging mathematical prediction models (MPMs) provide guidance for the management of solid pulmonary nodules by providing a lung cancer risk score from demographic and radiologists-indicated imaging characteristics. We hypothesized calibrating the MPM risk score threshold to a local study cohort would result in improved performance over the original recommended MPM thresholds. We compared the pre- and post-calibration performance of four MPM models and determined if improvement in MPM prediction occurs as nodules are imaged longitudinally. Read More

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http://dx.doi.org/10.1007/s00330-019-06168-xDOI Listing
April 2019
5 Reads

Bronchoscopic Treatment of Benign Endoluminal Lung Tumors.

Can Respir J 2019 27;2019:5269728. Epub 2019 Feb 27.

Yedikule Thoracic Diseases and Thoracic Surgery Hospital, Interventional Pulmonology Unit, Istanbul, Turkey.

Background And Aim: Endobronchial benign tumors are a rarely seen clinical entity but may cause significant symptoms. Endobronchial treatment has the potential for relieving symptoms while saving the patient from invasive surgical procedures. No trials have been published that present and compare the various endobronchial treatment modalities for endobronchial benign tumors. Read More

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http://dx.doi.org/10.1155/2019/5269728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415275PMC
February 2019
2 Reads

[Correlation between Plasma D-dimer Count and Features of
Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi 2019 Mar;22(3):151-156

Department of Thoracic Surgery, Ningbo No.2 Hospital, Ningbo 315000, China.

Background: More and more patients with small pulmonary nodules (SPN) can be found along with the developing of chest low-dose computed tomography (LDCT). With current examinations not all the SPN can be diagnosed to be benign or malignant and not all the malignant nodules can be diagnosed to be lymphatic metastasis. We need to study the correlation between plasma D-dimer count of patients before surgery with pathology features of non-small cell lung cancer (NSCLC). Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.03.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441113PMC
March 2019
1 Read

Left lower lobe sleeve resection for endobronchial schwannoma.

Ann Transl Med 2019 Feb;7(3):50

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

Schwannomas are mesenchymal neoplasms originating from Schwann cells of the nerve sheath. The tumor may appear anywhere in the body, while it has a predilection for extremities, trunk, retroperitoneum, head, and neck. Primary pulmonary schwannoma is extremely rare, accounting for less than 0. Read More

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http://dx.doi.org/10.21037/atm.2018.12.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389569PMC
February 2019
3 Reads

Elevated heme synthesis and uptake underpin intensified oxidative metabolism and tumorigenic functions in non-small cell lung cancer cells.

Cancer Res 2019 Mar 22. Epub 2019 Mar 22.

Biological Sciences, The University of Texas at Dallas

Tumors of human non-small cell lung cancer (NSCLC) are heterogeneous but exhibit elevated glycolysis and glucose oxidation relative to benign lung. Heme is a central molecule for oxidative metabolism and ATP generation via mitochondrial oxidative phosphorylation (OXPHOS). Here we showed that levels of heme synthesis and uptake, mitochondrial heme, oxygen-utilizing hemoproteins, oxygen consumption, ATP generation, and key mitochondrial biogenesis regulators were enhanced in NSCLC cells relative to non-tumorigenic cells. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2156DOI Listing
March 2019
1 Read

Phyllodes tumor with a benign heterologous osseous component: a diagnostic challenge.

APMIS 2019 Mar 22. Epub 2019 Mar 22.

Department of Pathology, Copenhagen University Hospital, Rigshospitalet, København Ø, Denmark.

Phyllodes tumors (PTs) are rare fibroepithelial neoplasms of the breast and constitute 0.3-1% of all primary breast tumors. They should be characterized in to a benign, borderline or malignant category based on a combination of histological features. Read More

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http://dx.doi.org/10.1111/apm.12949DOI Listing
March 2019
2 Reads

Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry.

J Proteome Res 2019 Mar 29. Epub 2019 Mar 29.

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China.

The incidence of nonsmoking female patients with non-small cell lung cancer (NSCLC) has increased in recent decades; however, the pathogenesis of patients is unclear, and early diagnosis biomarkers are in urgent need. In this study, 136 nonsmoking female subjects (65 patients with NSCLC, 6 patients with benign lung tumors, and 65 healthy controls) were enrolled, and their metabolic profiling was investigated by using pseudotargeted gas chromatography-mass spectrometry. A total of 56 annotated metabolites were found and verified to be significantly different in nonsmoking females with NSCLC compared with the control. Read More

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http://dx.doi.org/10.1021/acs.jproteome.9b00069DOI Listing
March 2019
4 Reads
4.245 Impact Factor

En-bloc resection of thoracic tumors invading the spine: a single-center experience.

Ann Thorac Surg 2019 Mar 15. Epub 2019 Mar 15.

Department of thoracic surgery, Paris-Center University-Hospital, AP-HP, Paris-Descartes University, Paris, France. Electronic address:

Background: Vertebral involvement by a thoracic tumor has long been considered as a limit to surgical treatment, and despite advances, such an invasive surgery remains controversial. The aim of this study was to characterize a single-center cohort, and to evaluate the outcome, focusing on survival and complications.

Methods: We retrospectively reviewed the data of all patients operated on for tumors involving the thoracic spine in an 8-year period. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.02.019DOI Listing
March 2019
1 Read

The value of 18F-FDG PET/CT in the diagnosis of different size of solitary pulmonary nodules.

Medicine (Baltimore) 2019 Mar;98(11):e14813

The First Affiliated Hospital of Soochow University, Suzhou.

This study aimed to evaluate the diagnostic value of F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) for solitary pulmonary nodules (SPNs) with different diameters.One hundred eighty two consecutive patients with SPN who underwent F-FDG PET/CT examination were retrospectively studied. Patients were categorized into 3 groups according to the diameter of nodules: Group A with the diameter of greater than or equal to 6 mm and less than or equal to 10 mm; Group B with diameter greater than 10 mm and less than or equal to 20 mm; Group C with diameter greater than 20 mm and less than or equal to 30 mm. Read More

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http://dx.doi.org/10.1097/MD.0000000000014813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426628PMC
March 2019
1 Read

Malignant perivascular epithelioid cell tumor of the lung synchronous with a primary adenocarcinoma: one case report and review of the literature.

BMC Cancer 2019 Mar 15;19(1):235. Epub 2019 Mar 15.

Department of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University, No. 241 West Huaihai Road, Shanghai, 200030, China.

Background: Perivascular Epithelioid Cell Tumors (PEComa) is an extraordinarily rare mesenchymal neoplasm especially the malignant type originating from the lung. To date, only 8 cases of malignant or malignant potential pulmonary PEComa had been documented. Firm diagnostic criteria for malignant pulmonary PEComa need urgently to be established. Read More

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http://dx.doi.org/10.1186/s12885-019-5383-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419825PMC
March 2019
1 Read

Ciliated muconodular papillary tumors of the lung: Cytologic features and diagnostic pitfalls in intraoperative examinations.

Diagn Cytopathol 2019 Mar 8. Epub 2019 Mar 8.

Department of Thoracic Surgery, Kitasato University School of Medicine, Kanagawa, Japan.

Ciliated muconodular papillary tumors (CMPTs) of the lung are rare, likely benign neoplastic lesions. Here we describe a case of a CMPT, focusing on its cytologic features, which to our knowledge have not been reported previously. Owing to dull back pain, a 69-year-old male non-smoker underwent CT, which revealed a 1. Read More

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http://dx.doi.org/10.1002/dc.24169DOI Listing
March 2019
2 Reads

Multi-objective based radiomic feature selection for lesion malignancy classification.

IEEE J Biomed Health Inform 2019 Feb 28. Epub 2019 Feb 28.

Objective: Accurately classifying the malignancy of lesions detected in a screening scan is critical for reducing false positives. Radiomics holds great potential to differentiate malignant from benign tumors by extracting and analyzing a large number of quantitative image features. Since not all radiomic features contribute to an effective classifying model, selecting an optimal feature subset is critical. Read More

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http://dx.doi.org/10.1109/JBHI.2019.2902298DOI Listing
February 2019
1 Read

Multifocal pulmonary mucinous cystic neoplasm with ovarian-like stroma: Once in a blue moon-case report.

Respir Med Case Rep 2019 16;26:276-280. Epub 2019 Feb 16.

Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Jordan.

Mucinous cystic neoplasm of the lung is a rare well known entity in the WHO classification of lung tumors. It is defined as "a localized cystic mass filled with mucin and surrounded by a fibrous wall lined by well-differentiated columnar mucinous epithelium." The presence of ovarian-like stroma is not mentioned in this definition. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383178PMC
February 2019
6 Reads

MicroRNA‑92a promotes cell proliferation, migration and survival by directly targeting the tumor suppressor gene NF2 in colorectal and lung cancer cells.

Oncol Rep 2019 Apr 19;41(4):2103-2116. Epub 2019 Feb 19.

National Institute of Molecular Biology and Biotechnology, University of the Philippines, Diliman, Quezon City 1101, Philippines.

Inactivation of the tumor suppressor protein Merlin leads to the development of benign nervous system tumors in neurofibromatosis type2 (NF2). Documented causes of Merlin inactivation include deleterious mutations in the encoding neurofibromin2 gene (NF2) and aberrant Merlin phosphorylation leading to proteasomal degradation. Rare somatic NF2 mutations have also been detected in common human malignancies not associated with NF2, including colorectal and lung cancer. Read More

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http://dx.doi.org/10.3892/or.2019.7020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412542PMC
April 2019
1 Read

Thioredoxin Reductase as a Novel and Efficient Plasma Biomarker for the Detection of Non-Small Cell Lung Cancer: a Large-scale, Multicenter study.

Sci Rep 2019 Feb 25;9(1):2652. Epub 2019 Feb 25.

Keaise Center for Clinical Laboratory, Wuhan, China.

There is an increased demand for efficient biomarkers for the diagnosis of non-small cell lung cancer (NSCLC). This study aimed to evaluate plasma levels of TrxR activity in a large population to confirm its validity and efficacy in NSCLC diagnosis. Blood samples were obtained from 1922 participants (638 cases of NSCLC, 555 cases of benign lung diseases (BLDs) and 729 sex- and age-matched healthy controls). Read More

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http://dx.doi.org/10.1038/s41598-018-38153-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389956PMC
February 2019
1 Read

Genetic and immunohistochemical analyses of ciliated muconodular papillary tumors of the lung: A report of five cases.

SAGE Open Med Case Rep 2019 15;7:2050313X19830483. Epub 2019 Feb 15.

Department of Thoracic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.

Ciliated muconodular papillary tumors are benign lesions located in the peripheral lung field. Recent studies revealed and epidermal growth factor receptor gene mutations and anaplastic lymphoma kinase gene rearrangement. Five ciliated muconodular papillary tumors were screened for the V600E and mutations via polymerase chain reaction. Read More

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http://dx.doi.org/10.1177/2050313X19830483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378433PMC
February 2019
1 Read

Upshifting the Ipsilateral Proximal Femur May Provide Satisfactory Reconstruction of Periacetabular Pelvic Bone Defects After Tumor Resection.

Clin Orthop Relat Res 2018 Sep;476(9):1762-1770

Department of Orthopedics, Second Affiliated Hospital of Zhejiang University School of Medicine/Orthopedics Research Institute of Zhejiang University, Zhejiang, China.

Background: Pelvic ring reconstruction after resection of pelvic malignancies or aggressive benign tumors remains challenging, especially when the tumor invades periacetabular bone, resulting in a Type II resection as classified by Enneking and Dunham (removal of part or all of the acetabulum). Although numerous treatment approaches are in use, none is clearly superior to the others. An alternative involving use of the ipsilateral proximal femur as an autograft has not been well characterized, so we present our preliminary experience with this approach. Read More

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http://dx.doi.org/10.1007/s11999.0000000000000165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259805PMC
September 2018

Computer-assisted detection of metastatic lung tumors on computed tomography.

Asian Cardiovasc Thorac Ann 2019 Mar;27(3):199-207

5 Department of Thoracic Surgery, The University of Tokyo Hospital, Tokyo, Japan.

Background: This retrospective study examined the performance of computer-assisted detection in the identification of pulmonary metastases.

Methods: Fifty-five patients (41.8% male) who underwent surgery for metastatic lung tumors in our hospital from 2005 to 2012 were included. Read More

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http://dx.doi.org/10.1177/0218492319831836DOI Listing
March 2019
2 Reads

Increased Galectin-1 Expression in Thymic Epithelial Tumors.

Clin Lung Cancer 2018 Dec 21. Epub 2018 Dec 21.

Department of Radiation Oncology, Stanford University School of Medicine Stanford Cancer Institute, Stanford, CA.

Introduction: Thymic epithelial tumors (TET) are rare malignancies with a paucity of data on biology and therapeutics. Galectin-1 is a member of the β-galactoside binding protein family and has been shown to mediate tumor growth via modulation of immune cell function. This study examined galectin-1 expression in TET. Read More

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http://dx.doi.org/10.1016/j.cllc.2018.12.005DOI Listing
December 2018

Clinicopathological Features and Treatment Outcomes of Solid Pseudopapillary Neoplasms of the Pancreas: A 10-Year Case Series from a Single Center.

J Laparoendosc Adv Surg Tech A 2019 Feb 11. Epub 2019 Feb 11.

1 Department of General Surgery, Qilu Hospital, Shandong University, Jinan, China.

Background: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare pancreatic tumors. This study summarizes the clinicopathological characteristics and treatment outcomes of SPN patients through a 10-year single-center case series.

Materials And Methods: Medical records of patients diagnosed with SPNs and who underwent surgery between August 2007 and July 2017 at Qilu Hospital, Shandong University, were retrospectively analyzed. Read More

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http://dx.doi.org/10.1089/lap.2018.0704DOI Listing
February 2019
2 Reads

Evaluation of intracavitary carboplatin chemotherapy for treatment of pleural carcinomatosis in cats: a retrospective study of eight cases.

J Feline Med Surg 2019 Feb 5:1098612X19826401. Epub 2019 Feb 5.

1 ONCOVET, Veterinary Clinic of Referrals, Villeneuve d'Ascq, France.

Objectives: The aim of this study was to evaluate the benefit of intracavitary carboplatin chemotherapy in cats with malignant pleural effusion of epithelial origin.

Methods: The medical records of cats with a cytological diagnosis of neoplastic pleural effusion of epithelial origin were reviewed at three referral institutions between January 2013 and June 2018. Only cats treated with intracavitary carboplatin chemotherapy were enrolled. Read More

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http://dx.doi.org/10.1177/1098612X19826401DOI Listing
February 2019
2 Reads

Mucin staining is of limited value in addition to basic immunohistochemical analyses in the diagnostics of non-small cell lung cancer.

Sci Rep 2019 Feb 4;9(1):1319. Epub 2019 Feb 4.

Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, SE-221 00, Lund, Sweden.

Accurate diagnosis of histological type is important for therapy selection in lung cancer. Immunohistochemical (IHC) and histochemical stains are often used to complement morphology for definite diagnosis and are incorporated in the WHO classification. Our main aim was to compare different mucin stains and assess their value in relation to common IHC analyses in lung cancer diagnostics. Read More

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http://dx.doi.org/10.1038/s41598-018-37722-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362145PMC
February 2019
4 Reads

Bronchial angiolipoma successfully treated by sleeve resection of the right bronchus intermedius: a case report.

BMC Surg 2019 Jan 31;19(1):13. Epub 2019 Jan 31.

Department of Thoracic Surgery, Iwate Prefectural Central Hospital, Ueda 1-4-1, Morioka, 020-0066, Japan.

Background: Angiolipoma is a rare, benign tumor that primarily develops in the limbs and trunk. The occurrence of angiolipoma in the lungs is extremely rare; to date, only two cases of primary bronchial angiolipoma have been reported. Here, we report a case of angiolipoma of the right bronchus intermedius that was successfully treated with sleeve resection and reconstructive surgery. Read More

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http://dx.doi.org/10.1186/s12893-019-0481-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357366PMC
January 2019

[Clinical significance of recombinant virus-specific detection for viable circulating tumor cells in lung cancer patients].

Zhonghua Jie He He Hu Xi Za Zhi 2019 Feb;42(2):101-105

Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

To investigate the clinical significance of recombinant virus-specific detection for detecting viable circulating tumor cell (CTC) in lung cancer patients. From June 2017 to August 2018, 63 lung cancer patients diagnosed by imaging and pathology at the Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital were recruited for this study, including 38 cases of adenocarcinoma, 13 squamous cell carcinoma, and 12 small cell carcinoma. The patients consisted of 36 males and 27 females, with an average age of (65±11) years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2019.02.005DOI Listing
February 2019
2 Reads

[Treatment principle and surgical technique of pulmonary ground glass nodules].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):6-9

Department of thoracic surgery, Zhongshan hospital, Fudan university, Shanghai 200032, China.

Pulmonary ground glass nodule (GGN) is a term of radiological manifestation, which may be malignant or benign. GGN's imaging performance is diverse, and the management for pulmonary GGN remains controversial. Numerous clinical studies have clarified the safety of GGN follow-up and longer follow-up intervals, stricter surgical or biopsy indications are recommended. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.002DOI Listing
January 2019
1 Read

[Establishment and Verification of A Novel Predictive Model of Malignancy
for Non-solid Pulmonary Nodules].

Zhongguo Fei Ai Za Zhi 2019 Jan;22(1):26-33

Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.

Background: Mathematical predictive model is an effective method for preliminarily identifying the malignant pulmonary nodules. As the epidemiological trend of lung cancer changes, the detection rate of ground-glass-opacity (GGO) like early stage lung cancer is increasing rapidly, timely and proper clinical management can effectively improve the patients' prognosis. Our study aims to establish a novel predictive model of malignancy for non-solid pulmonary nodules, which would provide an objective evidence for invasive procedure and avoid unnecessary operation and the consequences. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.01.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348162PMC
January 2019
1 Read

[Preliminary Study on the Biological Markers for I-IIb Stage Non-small Cell Lung Cancer Based on a Serum-peptidomics].

Zhongguo Fei Ai Za Zhi 2019 Jan;22(1):20-25

Department of Thoracic Surgery, Third Central Hospital of Tianjin; Tianjin Institute of Hepatobiliary Disease; Tianjin Key Laboratory of Artificial Cell; Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin 300170, China.

Background: Non-small cell lung cancer (NSCLC) have the highest incidence of lung cancer which treatment principles are diagnosis and treatment as early as possible. Because of its insidious onset and lack of specific markers for early screening, most patients are at an advanced stage when diagnosed which results in a low 5-year survival rate and poor prognosis. Therefore Exploring a sensitive biomarker is the focus of current diagnosis and treatment of lung cancer. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.01.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348161PMC
January 2019

The prevalence of germline DICER1 pathogenic variation in cancer populations.

Mol Genet Genomic Med 2019 03 22;7(3):e555. Epub 2019 Jan 22.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland.

Background: The DICER1 syndrome is an autosomal dominant tumor-predisposition disorder associated with pleuropulmonary blastoma, a rare pediatric lung cancer. Somatic missense variation in "hotspot" codons in the RNaseIIIb domain (E1705, D1709, G1809, D1810, E1813) is observed in DICER1-associated tumors. Previously, we found the prevalence of germline pathogenic DICER1 variation in the general population is 1:10,600. Read More

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http://dx.doi.org/10.1002/mgg3.555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418698PMC
March 2019
15 Reads

[Leiomyoma of the esophagus : A further indication for robotic surgery?]

Chirurg 2019 Feb;90(2):125-130

Klinik für Allgemein-, Viszeral- und Thoraxchirurgie, Paracelsus Medizinische Privatuniversität Nürnberg, Prof.-Ernst-Nathan-Straße 1, 90419, Nürnberg, Deutschland.

Background: Leiomyomas of the esophagus are rare tumors but the most common benign lesion of the esophagus originating from smooth muscle cells. The symptoms are mainly determined by the size of the tumor and are caused by dysphagia and/or retrosternal pain. The majority of patients are however asymptomatic. Read More

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http://dx.doi.org/10.1007/s00104-019-0792-9DOI Listing
February 2019
3 Reads

The need for bone biopsies in the diagnosis of new bone lesions in patients with a known primary malignancy: A comparative review of 117 biopsy cases.

J Bone Oncol 2019 Feb 18;14:100213. Epub 2018 Dec 18.

Department of Orthopedics, Zhongshan Hospital, Fudan University, 180# Fenglin Road, Xuhui district, Shanghai, China.

Objective: This study used a clinical dataset to investigate the proportion of the newly found bone lesions in malignant patients diagnosed by biopsy as being benign, malignant but unrelated to the primary malignancy, or bone metastases of the primary malignancy. The clinical factors that might affect the correlation between bone lesions and the primary malignancy were also analyzed. It is expected to obtain some information contributing to the clinical decision-making regarding the need for biopsy of these lesions from the research results. Read More

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http://dx.doi.org/10.1016/j.jbo.2018.100213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329701PMC
February 2019
3 Reads

NETest Liquid Biopsy Is Diagnostic of Lung Neuroendocrine Tumors and Identifies Progressive Disease.

Neuroendocrinology 2019 Jan 17. Epub 2019 Jan 17.

University of Warmia and Mazury, Olsztyn, Poland.

Background: There are no effective biomarkers for the management of bronchopulmonary carcinoids (BPC). We examined the utility of a neuroendocrine multigene transcript "liquid biopsy" (NETest) in BPC for diagnosis and monitoring of the disease status.

Aim: To independently validate the utility of the NETest in diagnosis and management of BPC in a multicenter, multinational, blinded study. Read More

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http://dx.doi.org/10.1159/000497037DOI Listing
January 2019
19 Reads

KRAS mutations drive adenomatoid odontogenic tumor and are independent of clinicopathological features.

Mod Pathol 2019 Jan 14. Epub 2019 Jan 14.

Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Adenomatoid odontogenic tumor is a benign encapsulated epithelial odontogenic tumor that shows an indolent clinical behavior. We have reported in a few adenomatoid odontogenic tumors mutations in KRAS, which is a proto-oncogene frequently mutated in cancer such as lung, pancreas, and colorectal adenocarcinomas. We aimed to assess KRAS mutations in the hotspot codons 12, 13, and 61 in a large cohort of adenomatoid odontogenic tumors and to test the association of these mutations with clinical (age, site, tumor size, follicular/extrafollicular subtypes) and histopathological parameters. Read More

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http://www.nature.com/articles/s41379-018-0194-4
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http://dx.doi.org/10.1038/s41379-018-0194-4DOI Listing
January 2019
12 Reads

BAP1 Loss is a Useful Adjunct to Distinguish Malignant Mesothelioma Including the Adenomatoid-like Variant From Benign Adenomatoid Tumors.

Appl Immunohistochem Mol Morphol 2019 Jan 11. Epub 2019 Jan 11.

Institute of Pathology, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen.

Malignant mesothelioma (MM) can show areas closely mimicking reactive mesothelial proliferations or recapitulating benign adenomatoid tumors (ATs) making distinction on occasion impossible on morphologic ground alone, particularly in limited biopsy material. Recently, loss of BAP1 by immunohistochemistry (IHC) has been suggested as a potential marker for identifying MM, but data is still limited. We studied 264 MM cases (257 using tissue microarrays; 7 on conventional slides) and 42 genital ATs for BAP1 immunohistochemical expression. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000700DOI Listing
January 2019
2 Reads

Solitary Fibrous Tumor: Case Report of Intrapulmonary Location.

Case Rep Oncol Med 2018 2;2018:5745471. Epub 2018 Dec 2.

Department of Thoracic Surgery, Teaching Hospital Mohammed VI, University Cadi Ayyad, Morocco.

Solitary fibrous tumors are relatively rare neoplasms that commonly occur in the pleura, especially visceral pleura. However, an intrapulmonary site of this kind of tumors is even rarer. These tumors can be characterized by a heterogeneous evolution and have a benign or malignant behavior. Read More

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https://www.hindawi.com/journals/crionm/2018/5745471/
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http://dx.doi.org/10.1155/2018/5745471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304895PMC
December 2018
7 Reads

Expression of Prostate-Specific Membrane Antigen (PSMA) on Biopsies Is an Independent Risk Stratifier of Prostate Cancer Patients at Time of Initial Diagnosis.

Front Oncol 2018 20;8:623. Epub 2018 Dec 20.

Pathology of the University Hospital Schleswig-Holstein and Research Center Borstel, Leibniz Lung Center, Luebeck, Germany.

Stratifying prostate cancer (PCa) patients into risk groups at time of initial diagnosis enabling a risk-adapted disease management is still a major clinical challenge. Existing studies evaluating the prognostic potential of PSMA (prostate-specific membrane antigen) for PCa were performed on radical prostatectomy specimens (RPE), i.e. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2018.00623/
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http://dx.doi.org/10.3389/fonc.2018.00623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307416PMC
December 2018
3 Reads

Parotid incidentalomas on positron emission tomography: what is their clinical significance?

Nucl Med Commun 2019 Mar;40(3):264-269

Norwich Radiology Academy, The Cotman Centre, Norwich.

Objective And Aim: The increased use of PET/CT in cancer staging has resulted in more incidental findings in unexpected locations, making this a challenge for the radiologist interpreting the study. Our aim was to determine the frequency of parotid incidentalomas and to assess the ability of PET/CT to characterize them.

Patients And Methods: At the Norfolk and Norwich University Trust, in between October 2010 to October 2015, 4044 patients had a PET/CT examination. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000961DOI Listing
March 2019
2 Reads

Change of Circulating and Tissue-Based miR-20a in Human Cancers and Associated Prognostic Implication: A Systematic Review and Meta-Analysis.

Biomed Res Int 2018 25;2018:6124927. Epub 2018 Nov 25.

Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Orthopaedic Department, China-Japan Friendship Hospital, Chaoyang District, Beijing, China.

Background: Previous literatures have investigated the change of miR-20a expression level in the progression of multiple cancers and its influence on patients' survival outcome, but results of now-available evidence are inconsistent.

Objective: To elucidate the prognostic value of circulating and tissue-based miR-20a for patients with various cancers.

Methods: A systematic search and review of eligible publications were carried out in three electronic databases including the Cochrane Library, PubMed, and Embase, and the methodological quality of included studies was assessed according to Newcastle-Ottawa Scale (NOS). Read More

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http://dx.doi.org/10.1155/2018/6124927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286746PMC
April 2019
9 Reads

Clinical Validation of a Protein Biomarker Panel for Non-Small Cell Lung Cancer.

J Korean Med Sci 2018 Dec 13;33(53):e342. Epub 2018 Dec 13.

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

We validated the diagnostic performance of a previously developed blood-based 7-protein biomarker panel, AptoDetect™-Lung (Aptamer Sciences Inc., Pohang, Korea) using modified aptamer-based proteomic technology for lung cancer detection. Non-small cell lung cancer (NSCLC), 200 patients and benign nodule controls, 200 participants were enrolled. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2018.3
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http://dx.doi.org/10.3346/jkms.2018.33.e342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306327PMC
December 2018
4 Reads

Clinical characteristics and treatment outcomes in six cases of malignant tenosynovial giant cell tumor: initial experience of molecularly targeted therapy.

BMC Cancer 2018 Dec 29;18(1):1296. Epub 2018 Dec 29.

Ludwig Center at Dana-Farber/Harvard and Center for Sarcoma and Bone Oncology, Department of Medical Oncology, Harvard Medical School, Boston, MA, USA.

Background: Although tenosynovial giant cell tumor (TGCT) is classified as a benign tumor, it may undergo malignant transformation and metastasize in extremely rare occasions. High aberrant expression of CSF1 has been implicated in the development of TGCT and recent studies have shown promising activity of several CSF1R inhibitors against benign diffuse-type TGCT; however, little is known about their effects in malignant TGCT.

Case Presentation: Information from six consenting patients (3 men, 3 women) with malignant TGCT presenting to Dana-Farber Cancer Institute for initial or subsequent consultation was collected. Read More

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http://dx.doi.org/10.1186/s12885-018-5188-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311045PMC
December 2018

Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart.

Exp Oncol 2018 12;40(4):336-342

Amosov National Institute of Cardiovascular Surgery, Kyiv 02000, Ukraine.

Background: Tumors of the heart are uncommon and usually benign (in 93% cases myxomas are observed). More often secondary, metastatic tumors are detected in the heart, as a rule, at pronounced progression of the malignant neoplasm with multiple lesions of other internal organs (lung, pleura, liver, etc.). Read More

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December 2018
2 Reads