731 results match your criteria Benign Lesions of the Ovaries


A rare case of highly differentiated follicular carcinoma in ovary with FGFR4 Gly388Arg polymorphism: a case report and literature review.

J Ovarian Res 2022 Jun 14;15(1):71. Epub 2022 Jun 14.

Department of Gynecologic Oncology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Background: Highly differentiated follicular carcinoma (HDFCO) is a rare form of struma-derived thyroid-type carcinoma in ovary, defined as ovarian struma spreading beyond ovary but consisting of benign thyroid tissues. No more than 30 cases of HDFCO have been reported since it was first recognized in 2008. The clinicopathologic and molecular features of HDFCO remain unclear up till now. Read More

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Microcystic stromal tumor of the ovary: a recurrent case with somatic CTNNB1 missense mutation.

Virchows Arch 2022 Jun 14. Epub 2022 Jun 14.

Department of Gynecology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Microcystic stromal tumors (MCSTs) of the ovary are rare sex cord-stromal tumors that are considered benign neoplasms because almost all cases display unilateral, localized lesions and have benign outcomes, except for one recurrent case with familial adenomatous polyposis and another initial metastatic case with a CTNNB1 mutation. We report herein a sporadic case that relapsed as intra-abdominal spread 9 years and 1 month after primary left salpingo-oophorectomy for torsion of the ovarian tumor pedicle. The tumor relapsed as multiple disseminations at the subabdominal wall, Douglas pouch, and omentum. Read More

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Ovarian growing teratoma syndrome with multiple metastases in the abdominal cavity and liver: A case report.

World J Clin Cases 2022 May;10(14):4704-4708

Hangzhou Women's Hospital, Zhejiang Chinese Medical University, Hangzhou 310008, Zhejiang Province, China.

Background: Growing teratoma syndrome (GTS) is an unusual presentation of an amazing transformation of teratoma from malignant to benign on pathology during or after systemic or intraperitoneal chemotherapy. The definitive pathogenesis is still not fully understood due to the lack of large-sample studies.

Case Summary: A 53-year-old woman underwent radical surgery and postoperative intraperitoneal chemotherapy due to immature teratoma of the right ovary at the age of 28. Read More

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Sebaceous adenoma occurring within an intracranial dermoid cyst.

Neuropathology 2022 May 25. Epub 2022 May 25.

Department of Neurosurgery, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.

Among intracranial cystic lesions, dermoid cysts and epidermoid cysts are relatively common benign tumors. In a small number of these tumors, it is known that squamous cell carcinomas arise in the lining epithelium of the cysts. Among tumors derived from the appendage, only one case of hidradenoma within a dermoid cyst and no cases of sebaceous tumor have been reported previously. Read More

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Ultrasound-Guided Tru-Cut Biopsy in Gynecological and Non-Gynecological Pelvic Masses: A Single-Center Experience.

J Clin Med 2022 Apr 30;11(9). Epub 2022 Apr 30.

Institute for Maternal and Child Health, I.R.C.C.S. "Burlo Garofolo", 34137 Trieste, Italy.

Aim: The aim of this study was to evaluate the feasibility of adequacy, accuracy, and safety of ultrasound-guided tru-cut biopsy in managing malignant and benign abdominopelvic masses in a selected population and critically discuss some issues in different situations, which deserve some reflections on those practices.

Materials And Methods: This is a retrospective study involving 42 patients who underwent transvaginal or transabdominal tru-cut biopsy between August 2017 and November 2021. The inclusion criteria were poor health status or primary inoperable advanced tumor, suspicion of recurrence or metastasis to the ovaries or peritoneum in gynecological and non-gynecological pelvic malignancies. Read More

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Anastomosing Hemangioma of the Ovary With Leydig Cell Hyperplasia: A Clinicopathologic Study of 12 Cases.

Int J Gynecol Pathol 2022 Apr 12. Epub 2022 Apr 12.

Department of Pathology, Yale School of Medicine, New Haven, Connecticut.

Anastomosing hemangioma is a recently described vascular neoplasm, initially identified in the male genitourinary tract. Since its first description, it has been reported at multiple anatomic sites, including rare cases in the female genital tract, most in the ovary. Herein we report the largest series to date of 12 ovarian anastomosing hemangiomas identified at our institution over a 15-yr period. Read More

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Ovarian fibromatosis: "The black garland sign".

Radiologia (Engl Ed) 2022 Mar-Apr;64(2):164-168

Servicio de Radiodiagnóstico, Hospital General Universitario de Alicante, Alicante, Spain.

The main objective in the imaging differential diagnosis of an ovarian mass is to establish whether it is cystic or solid; solid lesions are less common. Ovarian fibromatosis is a benign disease of the ovary that is rarely included in the differential diagnosis of solid ovarian lesions. Characteristic features of masses that have a fibrous component are low signal in T1-weighted MRI sequences and especially in T2-weighted MRI sequences. Read More

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Mucinous Tumor Coexisting With Mesonephric-like Proliferation/Tumor in the Ovary: A Novel Association.

Am J Surg Pathol 2022 Apr 12. Epub 2022 Apr 12.

Departments ofPathology.

The literature indicates that mesonephric carcinoma (MC) and mesonephric-like adenocarcinoma (MLA) typically lack mucinous and squamous features/differentiation. We report 4 cases of ovarian mucinous tumors (1 mucinous cystadenofibroma and 3 mucinous borderline tumors/atypical proliferative mucinous tumors [MBT/APMT]) co-existing with mesonephric-like lesions which were highlighted by Gata3 and Pax8 expression. All cases contained benign mesonephric-like proliferations (MLP) which focally displayed gastrointestinal-type mucinous metaplasia/differentiation and some were intimately admixed with mucinous glands associated with the mucinous tumor. Read More

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Endometriosis in para-aortic lymph node resembling a malignancy: a case report and literature review.

BMC Womens Health 2022 04 5;22(1):101. Epub 2022 Apr 5.

Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People's Republic of China.

Background: Endometriosis is a common benign gynecological disease characterized by growing-functioning endometrial tissue outside the uterus. Extra-pelvic endometriosis, which accounts for approximately 12% of endometriosis, is more challenging to diagnose because of its distance from the pelvic organs. Halban's theory of benign metastasis indicates that endometrial cells can appear in extra-pelvic organs via lymphatic and blood vessels, but endometrial lymph node metastasis cases are still rare. Read More

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Laparoscopic Triple Segmental Bowel Resection for Endometriosis Revealed by Rectal Obstruction during Infertility Treatment.

Case Rep Gastroenterol 2022 Jan-Apr;16(1):29-36. Epub 2022 Feb 10.

Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan.

Intestinal endometriosis is a benign disease characterized by ectopic growth of the endometrium and causes extensive fibrosis and adhesions in response to repeated episodes of bleeding and inflammation with the menstrual cycle. We encountered a rare case of intestinal endometriosis that caused complete rectal obstruction in a 34-year-old woman undergoing infertility treatment. Colonoscopy showed rectal stenosis and obstruction but no evidence of a tumor. Read More

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February 2022

Incidence of thyroid nodules in early stage autosomal polycystic kidney disease.

BMC Nephrol 2022 03 3;23(1):85. Epub 2022 Mar 3.

Department of Nephrology, Transplantology and Internal Diseases, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.

Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. Defect in cilia-mediated signaling activity is a crucial factor leading to cyst formation. Hence, ADPKD is regarded as a systemic disorder with multiple extrarenal complications, including cysts in other organs, for instance, the liver, pancreas, spleen, or ovaries. Read More

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Mucinous Cystic Neoplasm of Mesentery: A Case Report.

Cureus 2022 Jan 21;14(1):e21482. Epub 2022 Jan 21.

Surgery, Baramati Hospital, Pune, IND.

Mucinous cystic neoplasms are very rare tumours. They may originate from ovaries, pancreas or other intra-abdominal sites but they rarely originate from the mesentery. They can be asymptomatic or present as an abdominal mass or abdominal pain. Read More

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January 2022

Diagnostic Accuracy of Whole-Body Computed Tomography for Incidental Ovarian Tumors in Patients with Prior Breast Cancer.

Diagnostics (Basel) 2022 Jan 29;12(2). Epub 2022 Jan 29.

Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, No. 5, Fuxing St., Guishan Dist., Taoyuan City 33382, Taiwan.

Whole-body computed tomography (WBCT) serves as the first-line imaging modality for breast cancer follow-up. To investigate the imaging characteristics and diagnostic accuracy of WBCT for incidental ovarian tumors in patients with prior breast cancer, we retrospectively reviewed a consecutive cohort of 13,845 patients with breast cancer, of whom 149 had pathologically-proven ovarian lesions. We excluded patients with ovarian diagnosis before breast cancer, CT scan not including ovary, CT-pathology interval >30 days, and severe CT artifact. Read More

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January 2022

Primary ovarian fibroma in a postmenopausal woman: A case report.

Int J Surg Case Rep 2022 Mar 18;92:106842. Epub 2022 Feb 18.

Department of Gynecology and Obstetrics, University Hospital Center Ibn Rochd, Casablanca 20100, Morocco; Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.

Introduction: Primary ovarian leiomyoma is a rare benign tumor of the ovary seen in women between 20 and 65 years old. Clinical, ultasonographic and tumor marker data remain the best preoperative approach currently available for ovarian tumours. Only pathological examination can establish the diagnosis. Read More

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Gynecologists Need to Be Vigilant-Two Case Reports of Intravascular Leiomyomatosis and Literature Review.

Front Oncol 2022 7;12:840096. Epub 2022 Feb 7.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Background: Intravascular leiomyomatosis is a rare benign lesion with malignant potential. The cases are sporadic. Most patients have no clinical symptoms, and the preoperative diagnostic rate is low. Read More

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February 2022

Standardizing the surgical management of benign ovarian tumors in children and adolescents: A best practice Delphi consensus statement.

Pediatr Blood Cancer 2022 04 4;69(4):e29589. Epub 2022 Feb 4.

Department of Paediatric Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Aim: No widely agreed consensus protocols exist for the management of benign ovarian tumors (BOT) in children. This presents a substantial risk for suboptimal management. We aimed to generate multispecialty consensus guidance to standardize surgical management and provide a clear follow-up protocol for children with BOTs. Read More

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Ovarian torsion: diagnosis, surgery, and fertility preservation in the pediatric population.

Eur J Pediatr 2022 Apr 30;181(4):1405-1411. Epub 2022 Jan 30.

Department of Pediatric Emergency Care, APHP - Hôpital Robert Debré, 48 Boulevard Serurier, 75019, Paris, France.

Ovarian torsion is rare in the pediatric population. Delayed diagnosis can significantly impact fertility. The aim of this review is to highlight current knowledge regarding clinical presentation, diagnosis, surgical management, and follow-up in the pediatric population. Read More

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Primary ovarian mucinous carcinoid arising in a mature cystic teratoma-A rare entity.

Indian J Pathol Microbiol 2022 Jan-Mar;65(1):184-186

Department of Surgery, Believers Church Medical College Hospital, Thiruvalla, Kerala, India.

Mature cystic teratomas are benign unilateral tumors often diagnosed in young females. Carcinoid tumors are slow-growing tumors originating from neuroendocrine cells. A thorough histopathological study of the tumor is mandatory and the surgical treatment is adapted according to the characteristics of the patient. Read More

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February 2022

Efficacy of IOTA simple rules, O-RADS, and CA125 to distinguish benign and malignant adnexal masses.

J Ovarian Res 2022 Jan 23;15(1):15. Epub 2022 Jan 23.

Department of Ultrasound, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, 350014, Fujian Province, China.

Objective: Ovarian cancer is the most deadly deadliest gynecological tumor in the female reproductive system. Therefore, the present study sought to determine the diagnostic performance of International Ovarian Tumor Analysis Simple Rules (IOTA SR), the Ovarian-Adnexal Reporting and Data System (O-RADS), and Cancer Antigen 125 (CA125) in discriminating benign and malignant ovarian tumors. The study also assessed whether a combination of the two ultrasound categories systems and CA125 can improve the diagnostic performance. Read More

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January 2022

Ovarian microcystic stromal tumour: from morphological observations to syndromic associations.

Histopathology 2022 May 28;80(6):898-904. Epub 2022 Feb 28.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.

Microcystic stromal tumour (MST) is a rare, usually benign, ovarian neoplasm characterized morphologically in its classic form by a distinctive triad of features comprising microcysts, solid cellular regions and fibrous stroma. Variant morphology also occurs, including the presence of nests, tubules, cords and signet ring cells. Immunohistochemically, this neoplasm is characterized by diffuse nuclear expression of β-catenin, cyclin D1, Wilms' tumour 1 (WT1) and steroidogenic factor 1 (SF1), as well as diffuse staining with forkhead box ligand 2 (FoxL2) and CD10. Read More

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Mucinous Ovarian Tumors With Anaplastic Mural Nodules: Case Report.

Front Med (Lausanne) 2021 14;8:753904. Epub 2021 Dec 14.

Department of Obstetrics and Gynecology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Ovarian mucinous cystic tumors may be associated with various types of mural nodules, which can be classified as benign or malignant (anaplastic carcinoma, sarcoma, carcinosarcoma). However, anaplastic malignant nodules have rarely been reported. Here, we present a case of a 35-year-old woman who presented with abdominal discomfort. Read More

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December 2021

Well-developed Cerebellum in an Ovarian Mature Teratoma From a Pregnant Female.

Int J Gynecol Pathol 2021 Dec 27. Epub 2021 Dec 27.

University of Missouri School of Medicine (M.A.S); Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital (B.J.Q., M.R.N.); and Division of Neuropathology, Department of Pathology, Brigham and Women's Hospital (S.C.).

Teratomas are the most common neoplasm of the ovary, comprising over half of all diagnosed tumors in patients under 50. Most lesions are classified as benign mature teratomas and are histologically defined by the presence of mature tissues from one or more of the embryological germ layers: ectoderm, mesoderm, and endoderm. Neuroectodermal derivatives, including glia, neurons, ependymal cells, and meninges are present in a third to half of mature teratomas. Read More

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December 2021

Combined expression of HOXA11 and CD10 identifies endometriosis versus normal tissue and tumors.

Ann Diagn Pathol 2022 Feb 23;56:151870. Epub 2021 Nov 23.

Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Dag Hammarskjölds väg 20, SE-75185 Uppsala, Sweden. Electronic address:

The gold standard for diagnosing endometriosis is by laparoscopic visual demonstration of ectopic endometrial lesions outside the uterus, preferably verified by biopsy and microscopical examination. Molecular markers to facilitate the microscopical diagnosis of endometriosis and for distinguishing endometriosis from other benign and malignant lesions are lacking. Our aim was to test and validate an immunohistochemical antibody panel for improved diagnostic accuracy of endometriosis. Read More

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February 2022

Progression of Cystadenoma to Mucinous Borderline Ovarian Tumor in Young Females: Case Series and Literature Review.

J Pediatr Adolesc Gynecol 2022 Jun 27;35(3):359-367. Epub 2021 Nov 27.

Department of Obstetrics, Gynecology and Reproductive Sciences at Yale New Haven Hospital and Yale University School of Medicine, New Haven, Connecticut. Electronic address:

Study Objective: To study the progression of benign ovarian lesions to mucinous borderline ovarian tumors (mBOTs); analyze the clinicopathologic features, diagnosis, and management of mBOTs in pediatric and adolescent girls; and provide a review of the literature on mBOTs in this population.

Design: Retrospective chart review of female adolescents younger than 18 years diagnosed with mBOTs between July 2017 and February 2021.

Setting: Yale New Haven Hospital, New Haven, Connecticut; and Yale New Haven Health Bridgeport Hospital, Bridgeport, Connecticut. Read More

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Conservative Management of Asymptomatic Adnexal Masses Classified as Benign by the IOTA ADNEX Model: A Prospective Multicenter Portuguese Study.

Diagnostics (Basel) 2021 Oct 27;11(11). Epub 2021 Oct 27.

Maternidade Dr. Alfredo da Costa, Centro Hospitalar Universitário Lisboa Central (CHULC), 2890-495 Lisbon, Portugal.

This prospective multicentric study aiming to determine the incidence of complications (malignant transformation, torsion or rupture) during conservative management of adnexal masses was performed in two Portuguese tertiary referral hospitals. It included ≥18-year-old, non-pregnant patients with asymptomatic adnexal masses (associated IOTA ADNEX risk of malignancy < 10%) sonographically diagnosed between January 2016 and December 2020. Conservative patient management consisted of serial clinical and ultrasound assessment up to 60 months of follow-up, spontaneous resolution of the formation or surgical excision (median follow-up: 17. Read More

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October 2021

Delayed postpartum regression of theca lutein cysts with maternal virilization: A case report.

Clin Exp Reprod Med 2021 Dec 30;48(4):380-384. Epub 2021 Aug 30.

Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Theca lutein cysts are rare, benign lesions responsible for gross cystic enlargement of both ovaries during pregnancy. This condition is also termed hyperreactio luteinalis. Elevated human chorionic gonadotropin (hCG) levels or states of hCG hypersensitivity seem to promote these changes, which in up to 30% of patients produce clinical signs of hyperandrogenism. Read More

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December 2021

Surgical Management of Adnexal Masses in the Pediatric and Adolescent Age Group: Our Experience.

J Indian Assoc Pediatr Surg 2021 Sep-Oct;26(5):287-293. Epub 2021 Sep 16.

Department of Pediatric Surgery, Holyfamily Hospital, New Delhi, India.

Context: Adnexal masses in girls represent a wide pathological spectrum. We performed a retrospective analysis of clinical and diagnostic aspects of adnexal masses in girls.

Aims: To analyze the clinical characteristics and surgical management of adnexal masses in children and adolescents. Read More

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September 2021

Peutz-Jeghers syndrome: Skin manifestations and endocrine anomalies (Review).

Exp Ther Med 2021 Dec 29;22(6):1387. Epub 2021 Sep 29.

Department of Endocrinology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Peutz-Jeghers syndrome (PJS), a rare autosomal dominant serine/threonine kinase 11 ()/ liver kinase B1 () gene-related genodermatosis, is characterized by oral hyperpigmentation (OHP); multiple gastro-intestinal mucosal benign hamartomatous polyps causing local bleeding, occlusion, intussusception, post-resection small bowel syndrome, associated increased risk of small intestinal cancer (incidence during the third decade); and 76% cumulative higher risk than the global population of developing non-gastrointestinal tumors (female predominance) including ovarian/testicular neoplasia, pancreatic and gynecologic (breast, uterus, ovarian) cancers. Suggestive PJS-associated OHP requires STK11 genetic testing. Abdominal pain in an OHP patient may be related to PJS-associated polyps. Read More

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December 2021

Leiomyoma of the uterine round ligament: A case report.

Exp Ther Med 2021 Nov 13;22(5):1285. Epub 2021 Sep 13.

First Department of Anaesthesiology, Aretaieion Hospital, University of Athens, Medical School, Athens 11528, Greece.

Leiomyomas are common benign tumours that can arise in any anatomical structure containing smooth muscle. Their localization in the uterine round ligament is rare, although leiomyomas are the most frequent tumour of this structure. Leiomyomas present as inguinal, labial or intra-abdominal masses, and are often misdiagnosed as hernias or enlarged lymph nodes. Read More

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November 2021

Serous Borderline Ovarian Tumor Diagnosis, Management and Fertility Preservation in Young Women.

J Clin Med 2021 Sep 18;10(18). Epub 2021 Sep 18.

Department of Obstetrics Gynecology and Reproductive Medicine, Hospital Foch, Suresnes and University Versailles, 78180 Versailles, France.

Borderline ovarian tumors (BOT) represent about 10 to 20 percent of all epithelial tumors of the ovary. They constitute intermediate lesions between benign ovarian cysts and invasive carcinomas. They often occur in young women of reproductive age, and, albeit with a favorable prognosis, it may recur on the ipsilateral or contralateral ovary. Read More

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September 2021