686 results match your criteria Benign Lesions of the Ovaries


O-RADS MRI score: analysis of misclassified cases in a prospective multicentric European cohort.

Eur Radiol 2021 May 26. Epub 2021 May 26.

Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.

Objective: To retrospectively review the causes of categorization errors using O-RADS-MRI score and to determine the presumptive causes of these misclassifications.

Methods: EURAD database was retrospectively queried to identify misclassified lesions. In this cohort, 1194 evaluable patients with 1502 pelvic masses (277 malignant / 1225 benign lesions) underwent standardized MRI to characterize adnexal masses with histology or 2 years' follow-up as a reference standard. Read More

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Validation of tissue factor pathway inhibitor 2 as a specific biomarker for preoperative prediction of clear cell carcinoma of the ovary.

Int J Clin Oncol 2021 May 19. Epub 2021 May 19.

Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan.

Background: Tissue factor pathway inhibitor 2 (TFPI2) is a novel serum biomarker that discriminates ovarian clear cell carcinoma (CCC) from borderline ovarian tumors (BOTs) and non-clear cell epithelial ovarian cancers (EOCs). Here, we examined the performance of TFPI2 for preoperative diagnosis of CCC.

Methods: Serum samples were obtained preoperatively from patients with ovarian masses, who needed surgical treatment at five hospitals in Japan. Read More

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Benign Brenner tumour of the ovary: CT and MRI features.

Clin Radiol 2021 Apr 28. Epub 2021 Apr 28.

Anatomie Pathologique, Centre Jean PERRIN, 58 rue Montalembert, 63000 Clermont-Ferrand, France.

Aim: To evaluate the computed tomography (CT) and magnetic resonance imaging (MRI) features of benign Brenner tumours (BBT) of the ovary.

Material And Methods: This was a retrospective two-centre study comprising 35 female patients with a definitive diagnosis of BBT at histology in whom CT and/or MRI examinations had been performed. Two experienced radiologists reviewed the CT and MRI features of 39 ovarian BBT retrospectively with consensus reading. Read More

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Ovary: MRI characterisation and O-RADS MRI.

Br J Radiol 2021 Apr 30:20210157. Epub 2021 Apr 30.

Sorbonne Université, Paris, France.

Ultrasound has a high specificity for the diagnosis of a benign lesion in cases of classic appearing simple cyst, hemorrhagic cyst, endometrioma and dermoid. However, ultrasound can sometimes be limited for definitive characterisation and risk stratification of other types of lesions, including those with echogenic content that may appear solid, with or without blood flow. Frequently, MRI can be used to further characterise these types of lesions, due to its ability to distinguish solid tissue from non-tissue solid components such as fat, blood, or debris. Read More

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Low-grade mucinous appendiceal neoplasm mimicking an ovarian lesion: A case report and review of literature.

World J Clin Cases 2021 Apr;9(10):2334-2343

Department of Obstetrics and Gynecology, Maternidade Dr. Alfredo da Costa-Centro Hospitalar Universitário de Lisboa Central, Lisbon 2890-495, Portugal.

Background: Appendiceal tumors are rare lesions that may not be easily differentiated from primary ovarian lesions preoperatively, despite the use of advanced diagnostic methods by experienced clinicians.

Case Summary: A 59-year-old G2P2 woman, with chronic pelvic pain, underwent a pelvic ultrasound that revealed an adnexal mass measuring 58 mm × 34 mm × 36 mm, with irregular borders, heterogeneous echogenicity, no color Doppler vascularization and without acoustic shadowing. Normal ovarian tissue was visualized in contact with the lesion, and it was impossible to separate the lesion from the ovary by applying pressure with the ultrasound probe. Read More

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Insights into molecular pathways of endometriosis and endometriosis-related ovarian carcinoma.

Rom J Morphol Embryol 2020 Jul-Sep;61(3):739-749

Department of Morphofunctional Sciences I - Histology, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania;

Background: Endometriosis is a benign estrogen-dependent gynecological disease involving components of the female genital tract (uterus, Fallopian tubes, ovaries, large, round, and utero-sacral ligaments) and intra- and extraperitoneal regions. Since the moment of its etiopathogeny has been identified, the intrinsic capacity of endometriosis malignant transformation has been hypothesized.

Patients, Materials And Methods: Our study included a total number of 50 patients diagnosed with endometriosis (31 cases) and endometriosis-related ovarian carcinoma (EOC) (19 cases). Read More

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Radiologic-Histopathologic Correlation of Transvaginal US and Risk-reducing Salpingo-oophorectomy for Women at High Risk for Tubo-ovarian Carcinoma.

Radiol Imaging Cancer 2020 11 13;2(6):e190086. Epub 2020 Nov 13.

Departments of Radiology (M.D.S., N.E.C., W.R.M., M.M.L., E.B.S., A.P.W., K.E.M.), Pathology (A.P.S.), and Obstetrics/Gynecology (S.U., M.D.P., K.E.M.), Michigan Medicine, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109-5326.

Purpose: To examine radiologic-histopathologic correlation and the diagnostic performance of transvaginal US prior to risk-reducing salpingo-oophorectomy (RRSO) in women at high risk for tubo-ovarian carcinoma (TOC).

Materials And Methods: This retrospective study included 147 women (mean age, 49 years; age range, 28-75 years) at high risk for TOC who underwent transvaginal US within 6 months of planned RRSO between May 1, 2007, and March 14, 2018. Histopathologic results were reviewed. Read More

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November 2020

Bronchus-like Structures in Ovarian Teratomas: Report of a Series of a Previously Unreported Phenomenon With Potential For Misdiagnosis.

Int J Gynecol Pathol 2021 Mar 23. Epub 2021 Mar 23.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland (S.R., C.B., W.G.M.) Department of Pathology, Craigavon Area Hospital, Craigavon (R.S.), UK School for Women's and Infants' Health, University of Western Australia, Perth, WA, Australia (C.J.R.S.).

We report 10 cases of a previously undescribed lesion within ovarian teratomas which we designate bronchus-like structures. The lesions occurred in patients aged 16 to 56 yr (mean: 36) and involved the left ovary (n=5) or right ovary (n=5). Nine cases were mature teratomas (dermoid cysts/mature cystic teratomas or mature solid teratomas), 1 with somatic malignant transformation, and 1 was an immature teratoma. Read More

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Clinical and CT features of ovarian torsion in infants, children and adolescents.

Int J Gynaecol Obstet 2021 Feb 23. Epub 2021 Feb 23.

Department of Radiology, Qilu Hospital of Shandong University, Jinan, China.

Objective: To investigate the clinical features and computed tomography (CT) findings of pediatric ovarian torsion.

Methods: A retrospective analysis of the clinical and CT data of 61 newborns, infants, children, and adolescents with ovarian torsion confirmed by histopathology was performed.

Results: Clinical features included abdominal mass, abdominal pain, nausea and vomiting, and fever. Read More

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February 2021

Müllerian Mucinous Cystadenomas of the Ovary: A Report of 25 Cases of an Unheralded Benign Ovarian Neoplasm Often Associated With Endometriosis and a Brief Consideration of Neoplasms Arising From the Latter.

Int J Gynecol Pathol 2021 Feb 11. Epub 2021 Feb 11.

James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

A subset of ovarian mucinous tumors demonstrates müllerian-type epithelium, with such lesions variably designated "endocervical-like" and seromucinous since their popularization based on a report of borderline examples in 1989. While müllerian mucinous borderline tumors and carcinomas have been highlighted in the literature, there has been minimal attention given to benign müllerian mucinous tumors, particularly müllerian mucinous cystadenomas. Given the paucity of literature describing the features of müllerian mucinous cystadenomas/cystadenofibromas, diagnostic difficulties may arise when papillary features are present and in cases that show a subtle transition from endometriosis. Read More

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February 2021

Low-grade Mucinous Appendiceal Neoplasm: a Tumor in Disguise of Appendicitis.

J Gastrointest Cancer 2021 Feb 11. Epub 2021 Feb 11.

Department of Surgical Oncology, Bhagwan Mahaveer Cancer Hospital and Research Centre, Jaipur, Rajasthan, India.

Appendiceal mucinous neoplasms are a rare malignancy, but it is an important diagnostic entity. Ultrasonography and CT scan represent useful method for diagnosis; however, diagnosis is often incidental or intraoperative finding at resection for suspicion of appendicitis. Appendiceal mucinous neoplasm is commonly misdiagnosed as acute appendicitis, adnexal mass, or retroperitoneal tumors. Read More

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February 2021

Ovarian Fibromatosis: "The black garland sign".

Radiologia (Engl Ed) 2021 Feb 4. Epub 2021 Feb 4.

Servicio de Radiodiagnóstico, Hospital General Universitario de Alicante, Alicante, España.

The main objective in the imaging differential diagnosis of an ovarian mass is to establish whether it is cystic or solid; solid lesions are less common. Ovarian fibromatosis is a benign disease of the ovary that is rarely included in the differential diagnosis of solid ovarian lesions. Characteristic features of masses that have a fibrous component are low signal in T1-weighted MRI sequences and especially in T2-weighted MRI sequences. Read More

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February 2021

Abdominal cystic lymphangioma mimicking ovarian mass: A case report and literature review.

Mol Clin Oncol 2021 Feb 30;14(2):43. Epub 2020 Dec 30.

Second Department of Surgery, Aretaieion Hospital, Medical School, University of Athens, Athens 11528, Greece.

Cystic lymphangiomas are uncommon benign lesions extremely rare in the adult population. Most cases are found in the neck and axillary regions; while <1% of patients present with cystic lymphangiomas in the mesentery, greater omentum and retroperitoneum. The present report describes a rare case of large omental lymphangioma mimicking ovarian mass. Read More

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February 2021

A Collision between Cavernous-Capillary Hemangioma with Stromal Luteinization and Serous Cystadenoma.

Folia Med (Plovdiv) 2020 Dec;62(4):851-855

MBAL "Parvomai'' Ltd, Parvomai, Bulgaria.

A collision tumor represents a coexistence of two adjacent but histologically distinct tumors without histologic admixture in an organ. Serous tumors of the ovary are the most common forms of epithelial tumors, and cavernous hemangiomas are rare in the ovary. Howev-er, a collision between them is an extremely rare pathology. Read More

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December 2020

Symptomatic Primary Ovarian Leiomyoma in a Postmenopausal Woman: A Rare Entity.

J Midlife Health 2020 Jul-Sep;11(3):175-177. Epub 2020 Sep 29.

Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India.

Leiomyomas are benign mesenchymal neoplasms mostly seen in the uterus and are one of the most common pelvic masses seen in women, but primary ovarian leiomyomas are rare among all the benign ovarian tumors, which account only for 0.5%-1%. The definitive diagnosis of such lesions is difficult prior to surgical excision, as there are no pathognomonic symptoms or characteristic imaging findings. Read More

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September 2020

Molecular Aspects and Prognostic Significance of Microcalcifications in Human Pathology: A Narrative Review.

Int J Mol Sci 2020 Dec 24;22(1). Epub 2020 Dec 24.

Department of Experimental Medicine, University "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.

The presence of calcium deposits in human lesions is largely used as imaging biomarkers of human diseases such as breast cancer. Indeed, the presence of micro- or macrocalcifications is frequently associated with the development of both benign and malignant lesions. Nevertheless, the molecular mechanisms involved in the formation of these calcium deposits, as well as the prognostic significance of their presence in human tissues, have not been completely elucidated. Read More

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December 2020

Hyperreactio Luteinalis (Multiple Luteinized Follicle Cysts): A Report of 10 Cases.

Int J Gynecol Pathol 2020 Dec 14. Epub 2020 Dec 14.

James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (J.C.W., P.L., R.H.Y.).

Hyperreactio luteinalis is a rare entity arising in pregnancy and in the setting of gestational trophoblastic diseases (ie choriocarcinoma, molar pregnancy) that presents with, typically, bilateral ovarian enlargement due to numerous follicle cysts. While the phenomenon is benign and spontaneously regresses following delivery or treatment, a specimen may be seen in pathology when oophorectomy or cystectomy is performed to exclude malignancy or to manage acute complications such as torsion. Such resections may exhibit overlapping microscopic features with cystic granulosa cell tumors. Read More

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December 2020

Epidermal inclusion cyst in the thyroid gland.

Stem Cell Investig 2020 10;7:18. Epub 2020 Oct 10.

Division of Endocrinology, Department of Medicine, Nassau University Medical Center, East Meadow, NY, USA.

Epidermal inclusion cysts (EIC) are common benign lesions of the skin, ovaries, and testicles. However, their occurrence in thyroid gland is rare. We reported a case in which a 57-year-old male patient with history of nontoxic uninodular goiter presented with dysphonia and dysphagia. Read More

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October 2020

Management of ovarian masses in pregnancy: patient selection for interventional treatment.

Int J Gynecol Cancer 2021 Jun 10;31(6):899-906. Epub 2020 Nov 10.

Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Objective: The management of pregnant women with an adnexal tumor is still challenging and in the literature few data are available. The aim of this study was to describe the management and outcome of patients with ovarian masses detected during pregnancy. As secondary aims, we evaluated the prevalence of malignancy in the International Ovarian Tumor Analysis (IOTA) morphological classes of ovarian masses diagnosed during pregnancy, and created an algorithm for the management of patients with adnexal masses during pregnancy. Read More

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Pulmonary benign metastasizing leiomyomas: a case series of 23 patients at a single facility.

BMC Pulm Med 2020 Nov 10;20(1):292. Epub 2020 Nov 10.

Department of Obstetrics & Gynecology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), No. 1, Shuai Fu Yuan, Dong Cheng District, Beijing, China.

Background: Pulmonary benign metastasizing leiomyoma (PBML) is a rare disease characterized by leiomyoma of benign histopathology existing in the lungs. Because of its rarity, limited literature with a single case or small number of cases has been regarding to the clinical course, pathology or management of PBML.

Methods: A retrospective study was performed of all PBML cases diagnosed and managed at Peking Union Medical College Hospital (PUMCH) from 2001 to 2019. Read More

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November 2020

Clinical and Computed Tomographic Features of Ovarian Lesions in Infants, Children, and Adolescents: A Series of 222 Cases.

J Pediatr Adolesc Gynecol 2021 Jun 1;34(3):387-393. Epub 2020 Nov 1.

Radiology Department, Qilu Hospital of Shandong University, Shandong Province, China. Electronic address:

Study Objective: To investigate the clinical and computed tomography (CT) characteristics of ovarian lesions in infants, children, and adolescents.

Design, Setting, And Participants: A retrospective analysis of the clinical and CT data was performed in 222 patients who were 20 years or younger with ovarian lesions. Patients' age, medical history, symptoms, tumor marker levels, and CT imaging findings were recorded. Read More

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Differential Diagnosis of Endometriosis by Ultrasound: A Rising Challenge.

Diagnostics (Basel) 2020 Oct 20;10(10). Epub 2020 Oct 20.

Obstetrics and Gynecology, University of Cagliari, 09124 Cagliari, CA, Italy.

Ultrasound is an effective tool to detect and characterize endometriosis lesions. Variances in endometriosis lesions' appearance and distorted anatomy secondary to adhesions and fibrosis present as major difficulties during the complete sonographic evaluation of pelvic endometriosis. Currently, differential diagnosis of endometriosis to distinguish it from other diseases represents the hardest challenge and affects subsequent treatment. Read More

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October 2020

Tumors of the broad ligament: what and when to suspect such rare location.

Radiol Bras 2020 Sep-Oct;53(5):349-355

Hospital Professor Doutor Fernando Fonseca, Lisboa, Portugal.

Although secondary involvement of the broad ligament by malignant tumors arising elsewhere in the abdomen and pelvis is common, primary tumors in this location are rare. Tumors of the broad ligament can be of mesenchymal and mixed nature, such as leiomyoma, the most common neoplasm; epithelial tumors of Müllerian type, imposing a challenge to differentiate them from other adnexal masses; unique tumors from mesonephric origin; and tumor-like lesions. Most neoplasms in this region, whether benign or malignant, usually present clinically with vague symptoms and are often discovered during a routine gynecological examination. Read More

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October 2020

Adult granulosa cell tumors of bilateral ovaries with pure cystic presentation: A case report and review of literature.

Medicine (Baltimore) 2020 Oct;99(40):e22511

Department of Pathology, Xingtai People's Hospital, Hebei Medical University Affiliated Hospital, Xingtai, Hebei, P.R. China.

Rationale: Granulosa cell tumors (GCTs) are rare, hormonally active sex cord-stromal tumors that generally present as solid unilateral ovarian lesions. It's quite uncommon that they present as pure bilateral ovarian cysts. Histopathology remains the gold standard for making a diagnosis of GCTs. Read More

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October 2020

Teratoma of the adrenal gland: clinical experience and literature review.

Gland Surg 2020 Aug;9(4):1056-1064

Department of Radiology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Teratoma originates from pluripotent cells of two or more than two germ cell layers, and most of them are benign. Teratomas are found in the ovaries and testes. Retroperitoneal teratoma is rare, especially adrenal teratoma. Read More

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A Common Tumor with an Unusual Finding: Mature Cystic Teratoma Containing a Ganglioneuroma.

J Pediatr Adolesc Gynecol 2021 Feb 21;34(1):92-93. Epub 2020 Aug 21.

First Department of Obstetrics and Gynecology, School of Medicine, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.

Background: Ganglioneuromas (GNs) arise from peripheral or central areas of the autonomic nervous system, being benign lesions of neuroblastic origin.

Case: A 19-year-old Greek female patient was admitted to our clinic with symptoms of periodic lower abdominal pain and irritation since some months ago. Ultrasonography revealed a mass of 72 × 68 mm originating from the left ovary giving the characteristics of a typical dermoid cyst. Read More

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February 2021

A case of a vaginal Brenner tumor without a gland mimicking a borderline tumor: unusual morphology and diagnostic pitfalls.

J Int Med Res 2020 Aug;48(8):300060520946536

Department of Pathology, Tianjin Third Central Hospital, Tianjin, China.

Brenner tumor is a rare neoplasm of the vagina. This tumor is diagnosed according to the criteria of ovarian tumors. We report here a 64-year-old postmenopausal woman with a 2. Read More

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A giant ovarian mass in a 68-year-old female with persistent abdominal pain and elevated serum CA-125 level.

Prz Menopauzalny 2020 Jul 13;19(2):108-110. Epub 2020 Jul 13.

Department of Surgery, General University Hospital of Patras, Patras, Greece.

Introduction: Ovarian masses are common findings in general gynecology. However giant ovarian mass is a rare finding. In the literature, a few cases of giant ovarian mass have been mentioned sporadically, especially in elderly patients. Read More

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Radiomics derived from dynamic contrast-enhanced MRI pharmacokinetic protocol features: the value of precision diagnosis ovarian neoplasms.

Eur Radiol 2021 Jan 7;31(1):368-378. Epub 2020 Aug 7.

Radiology Department, Shanxi Medical University Second Affiliated Hospital, Taiyuan, 030001, Shanxi, China.

Objectives: To evaluate the efficiency of 2- and 3-class classification predictive tasks constructed from radiomics features extracted from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic (PK) protocol in discriminating among benign, borderline, and malignant ovarian tumors.

Methods: One hundred and four ovarian lesions were evaluated using preoperative DCE-MRI. Radiomics features were extracted from 7 types of DCE-MR images. Read More

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January 2021