614 results match your criteria Benign Lesions of the Ovaries


Diagnostic accuracy of CA125 and HE4 in ovarian carcinoma patients and the effect of confounders on their serum levels.

Curr Probl Cancer 2019 Jan 16. Epub 2019 Jan 16.

Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig City, Al Sharqia Governorate, Egypt.

Objectives: To evaluate the diagnostic accuracy of serum cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) in the prediction of malignant ovarian masses then to analyze the effect of personal criteria and medical diseases on this accuracy.

Study Design: This prospective study was performed in Zagazig University Hospital. The eligibility criteria for inclusion were; consecutive women, at any age ≥18 years, with established diagnosis of ovarian mass based on symptoms, signs, and imaging techniques. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2018.12.004DOI Listing
January 2019
1 Read

[Sex cord-stromal tumors of the ovary : Current aspects with a focus on granulosa cell tumors, Sertoli-Leydig cell tumors, and gynandroblastomas].

Authors:
F Kommoss H-A Lehr

Pathologe 2019 Feb;40(1):61-72

Institut für Pathologie, Medizin Campus Bodensee, Röntgenstr. 2, 88048, Friedrichshafen, Deutschland.

Sex cord-stromal tumors of the ovary (SCSTO) comprise a heterogeneous and fascinating group of neoplasms with diverse clinicopathological features, including benign lesions as well as tumors with malignant potential. Clinically, SCSTO may be associated with hyperestrogenic or androgenic function as a result of steroid hormone production by the tumor cells.Histological diagnosis may be challenging due to complex and sometimes overlapping morphological features of the various tumor types. Read More

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http://dx.doi.org/10.1007/s00292-018-0562-3DOI Listing
February 2019
4 Reads

High-grade serous ovarian carcinoma with mucinous differentiation: report of a rare and unique case suggesting transition from the "SET" feature of high-grade serous carcinoma to the "STEM" feature.

Diagn Pathol 2019 Jan 12;14(1). Epub 2019 Jan 12.

Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.

Background: High-grade serous carcinoma, a representative high-grade ovarian carcinoma, is believed to be closely associated with a TP53 mutation. Recently, this category of ovarian carcinoma has gained increasing attention owing to the recognition of morphological varieties of TP53-mutated high-grade ovarian carcinoma. Herein, we report the case of a patient with high-grade serous carcinoma with mucinous differentiation. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-019-0781-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330567PMC
January 2019
6 Reads

Adnexal torsion in symptomatic women: a single-centre retrospective study of diagnosis and management.

J Obstet Gynaecol 2018 Nov 8:1-6. Epub 2018 Nov 8.

a Department of Gynaecology , Fernandez Hospital , Hyderabad , India.

This retrospective study aimed to evaluate the sonographic diagnosis and management strategy of symptomatic adnexal torsion at a teaching hospital in Hyderabad, India. All women with abdominal pain and preoperative or operative diagnosis of adnexal torsion from January 2011 to December 2015 were included. A total of 76 women with 78 episodes were included; 28 (36%) occurred during pregnancy. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2018.1
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http://dx.doi.org/10.1080/01443615.2018.1494702DOI Listing
November 2018
5 Reads

Torsion Ovary, an Unusual Presentation of Carcinoma Appendix Detected in Whole-Body F-18 2-Fluoro 2-deoxy Glucose Positron Emission Tomography/Computed Tomography Scan.

Indian J Nucl Med 2018 Oct-Dec;33(4):331-333

Department of Nuclear Medicine, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.

Torsion ovary is one of the common emergencies in gynecology requiring surgery. Torsion ovary is generally caused by cystic lesions of ovary and benign tumors. Malignant tumors rarely present as torsion ovary. Read More

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http://www.ijnm.in/text.asp?2018/33/4/331/242954
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http://dx.doi.org/10.4103/ijnm.IJNM_97_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194758PMC
November 2018
11 Reads

Role of perfusion CT in the evaluation of adnexal masses.

J Obstet Gynaecol 2019 Feb 27;39(2):218-223. Epub 2018 Sep 27.

c Department of Cytology and Gynecological Pathology , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

The objective of this study was to evaluate the role of perfusion computed tomography (PCT) in differentiating benign from malignant adnexal masses. Twenty patients, each of pathologically proven malignant and benign adnexal masses who had undergone PCT on 64-slice CT scanner, were included in the study. The PCT parameters, viz. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2018.1
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http://dx.doi.org/10.1080/01443615.2018.1479382DOI Listing
February 2019
14 Reads

Multiple Synchronous Lesions in the Genital Tract of a Female: A Rare Combination with Unrelated Histogenesis.

J Menopausal Med 2018 Aug 31;24(2):133-137. Epub 2018 Aug 31.

Department of Pathology, MES Medical College, Perinthalmanna, Kerala, India.

Presenting a case of endometrioid adenocarcinoma of the endometrium, benign cystic teratoma of one ovary, fibrothecoma in the other ovary and adenomyosis in the uterus. Such a combination of synchronous lesion is very rare and is not reported in the English medical literature. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.6118/jmm.2018.24
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http://dx.doi.org/10.6118/jmm.2018.24.2.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127024PMC
August 2018
4 Reads

Clinicopathological Characteristics of Ovarian Metastasis from Colorectal and Pancreatobiliary Carcinomas Mimicking Primary Ovarian Mucinous Tumor.

Anticancer Res 2018 Sep;38(9):5465-5473

Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

Background/aim: A subset of carcinomas metastatic to the ovary can exhibit growth patterns closely resembling ovarian mucinous cystadenoma and borderline tumor. They can be misinterpreted as underlying primary ovarian mucinous tumors and can be erroneously used to suggest that the carcinomatous component arises from mucinous precursor lesions.

Materials And Methods: We investigated the clinicopathological characteristics of 11 cases of metastatic carcinoma that had metastasized from colorectal and pancreatobiliary carcinoma and mimicked primary ovarian mucinous tumors. Read More

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http://dx.doi.org/10.21873/anticanres.12879DOI Listing
September 2018
3 Reads

Adnexal lesions: Imaging strategies for ultrasound and MR imaging.

Diagn Interv Imaging 2018 Aug 31. Epub 2018 Aug 31.

Departments of Radiology, hôpital Tenon, Sorbonne universités, UPMC université Paris 06, Institut universitaire de cancérologie, Assistance publique-Hôpitaux de Paris, 4, rue de la Chine, 75020 Paris, France.

Adnexal lesions are routinely encountered in general practice. Ultrasound is the first line of investigation in determining the benign or malignant potential of an adnexal lesion. In the cases of classic simple cysts, hemorrhagic cysts, endometriomas, dermoids and obviously malignant lesions, ultrasound may be sufficient for management recommendations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22115684183015
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http://dx.doi.org/10.1016/j.diii.2018.06.003DOI Listing
August 2018
2 Reads

Anaplastic carcinoma in ovarian seromucinous cystic tumor of borderline malignancy.

J Ovarian Res 2018 Sep 3;11(1):77. Epub 2018 Sep 3.

Department of Obstetrics and Gynecology, Maruyama Memorial General Hospital, 2-10-5 Motomachi, Iwatukiku, Saitamashi, Saitama, 339-8521, Japan.

Background: The mortality rate of ovarian cancer is the highest among all gynecological malignancies in Japan. Ovarian tumors are classified as benign, borderline malignant, or malignant. Anticipating the histological subtype with imaging only is often difficult because of several histological subtypes of epithelial ovarian tumors (such as serous, mucinous, endometrioid, clear cell, and Brenner tumors). Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s13048-018-0449-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120074PMC
September 2018
13 Reads
2.430 Impact Factor

A multicenter clinical trial validating the performance of HE4, CA125, risk of ovarian malignancy algorithm and risk of malignancy index.

Gynecol Oncol 2018 10 24;151(1):159-165. Epub 2018 Aug 24.

Department of Obstetrics and Gynecology, Institute of Clinical Sciences, University of Gothenburg, Sweden.

Objective: To validate, in a multicenter clinical trial, the performance of biomarkers and algorithms for differential diagnosis in a population of women diagnosed with an unknown ovarian cyst or pelvic tumor.

Methods: Six hospitals in Western Sweden consecutively enrolled 638 women from September 2013 to February 2016. Serum, transvaginal ultrasound data, and basic patient characteristics were collected preoperatively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183115
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http://dx.doi.org/10.1016/j.ygyno.2018.08.025DOI Listing
October 2018
7 Reads

Uterine Lipoleiomyoma and Lipoma: A Rare Unique Case Report with Review of Literature.

Int J Appl Basic Med Res 2018 Jul-Sep;8(3):193-195

Department of Pathology, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India.

Uterine lipoleiomyoma and pure lipoma are uncommon and extremely rare benign lipomatous tumors. Reported incidence is 0.03%-0. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_119_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082001PMC
August 2018
3 Reads

Magnetic resonance imaging of pediatric adnexal masses and mimics.

Pediatr Radiol 2018 08 4;48(9):1291-1306. Epub 2018 Aug 4.

Department of Diagnostic Imaging, The Hospital for Sick Children, Medical Imaging, University of Toronto, 555 University Ave., Toronto, ON, M5G 1X8, Canada.

Evaluation of adnexal masses in children and adolescents relies on imaging for appropriate diagnosis and management. Pelvic MRI is indicated and adds value for all adnexal masses when surgery is considered or when ultrasound findings are indeterminate. Specifically, features on MR imaging can help distinguish between benign and malignant lesions, which not only influences the decision between surgery and conservative treatment, but also the type of surgery to be performed, including potential use of fertility-sparing approaches with minimally invasive techniques. Read More

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http://dx.doi.org/10.1007/s00247-018-4073-4DOI Listing

Adnexal lesions after hysterectomy: A retrospective observational study.

J Turk Ger Gynecol Assoc 2018 Jul 31. Epub 2018 Jul 31.

Department of Obstetrics and Gynecology, Unit of Gynecology and Endoscopic Surgery, University of Health Sciences, Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Turkey.

Objective: To characterize adnexal lesions detected in patients who had undergone previous hysterectomy with one or both ovaries conserved, and to define the clinical, pathological and surgical characteristics of the adnexal lesions in these patients.

Material And Methods: A retrospective observational study conducted on patients who had undergone a previous abdominal hysterectomy with one or both adnexa preserved and who had subsequently presented with an adnexal lesion. Characteristics of lesions, operative and pathological findings in patients who required a re-operation were noted. Read More

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http://dx.doi.org/10.4274/jtgga.2018.0051DOI Listing
July 2018
11 Reads

Mature ovarian cystic teratoma with disseminated nodular lesions in the pleural and peritoneal cavities: A case report.

Radiol Case Rep 2018 Jun 12;13(3):671-675. Epub 2018 Apr 12.

Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.

Mature ovarian cystic teratoma (MOCT) is the most common benign neoplasm of the ovary and has a wide spectrum of radiological presentations. Our aim was to present the radiological characteristics and pathologic findings of a patient with an atypical manifestation of this common disease. A 52-year-old Japanese woman was admitted to our hospital with a large cystic mass in the pelvis and an elevated squamous cell carcinoma antigen level. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055011PMC
June 2018
2 Reads

Incidental, low-fat variant of spindle cell lipoma: a novel tumour of the small intestine.

Pol J Pathol 2018;69(1):82-86

A woman underwent surgical intervention for a carcinoma of the ovary. In the intervention, a submucosal nodule of the ileum was found. Pathological study revealed a spindle cell lipoma (SCL). Read More

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http://dx.doi.org/10.5114/pjp.2018.75341DOI Listing
July 2018
32 Reads

Risk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over.

Chin Med J (Engl) 2018 Jun;131(11):1308-1313

Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Background: When considering the issue of recurrence, perimenopausal women may have more dilemma during management comparing with young women, for example, whether to retain the uterus and ovary during surgery, whether it is necessary to add adjuvant medicine treatment after operation, and there is no evidence for reference about using of gonadotropin-releasing hormone agonist. This study aimed to study the risk factors for the recurrence of ovarian endometriosis (EM) in patients aged 45 and over.

Methods: This is a retrospective nested case-control study. Read More

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http://dx.doi.org/10.4103/0366-6999.232790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987501PMC
June 2018
5 Reads

Bilateral ovarian masses with different histopathology in each ovary.

Clin Case Rep 2018 May 5;6(5):784-787. Epub 2018 Mar 5.

Reproductive Endocrine and Infertility Medicine Department King Fahad Medical City Riyadh Saudi Arabia.

We document the rare occurrence of multiple primary benign lesions that can occur in bilateral ovarian masses with benign imaging appearances and tumor markers. In addition, this case report contributes important information that may aid physicians in guiding their patients to make optimal clinical decisions together. Read More

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http://dx.doi.org/10.1002/ccr3.1466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930217PMC
May 2018
4 Reads

Clinical Etiology of Hypermetabolic Pelvic Lesions in Postoperative Positron Emission Tomography/Computed Tomography for Patients With Rectal and Sigmoid Cancer.

Ann Coloproctol 2018 Apr 30;34(2):78-82. Epub 2018 Apr 30.

Department of Radiology, The Catholic University of Korea, Daejeon St. Mary's Hospital, Daejeon, Korea.

Purpose: The purpose of this study was to present various clinical etiologies of hypermetabolic pelvic lesions on postoperative positron emission tomography/computed tomography (PET/CT) images for patients with rectal and sigmoid cancer.

Methods: Postoperative PET/CT images for patients with rectal and sigmoid cancer were retrospectively reviewed to identify hypermetabolic pelvic lesions. Positive findings were detected in 70 PET/CT images from 45 patients; 2 patients who were lost to follow-up were excluded. Read More

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http://dx.doi.org/10.3393/ac.2017.09.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951092PMC
April 2018
2 Reads

Reliability of IOTA score and ADNEX model in the screening of ovarian malignancy in postmenopausal women.

J Gynecol Obstet Hum Reprod 2019 Feb 28;48(2):103-107. Epub 2018 Apr 28.

Department of Obstetrics and Gynecology, hôpital Femme-Mère-Enfant (HFME), Hospices civils de Lyon, CHU de Lyon, 59, boulevard Pinel, 69000 Lyon, France; EMR 3738, Claude-Bernard University Lyon 1, 69000 Lyon, France.

Background: The IOTA (International Ovarian Tumor Analysis) group has developed the ADNEX (Assessment of Different NEoplasias in the adneXa) model to predict the risk that an ovarian mass is benign, borderline or malignant. This study aimed to test reliability of these risks prediction models to improve the performance of pelvic ultrasound and discriminate between benign and malignant cysts.

Material And Methods: Postmenopausal women with an adnexal mass (including ovarian, para-ovarian and tubal) and who underwent a standardized ultrasound examination before surgery were included. Read More

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http://dx.doi.org/10.1016/j.jogoh.2018.04.012DOI Listing
February 2019
8 Reads

High-grade serous carcinoma with discordant p53 signature: report of a case with new insight regarding high-grade serous carcinogenesis.

Diagn Pathol 2018 Apr 27;13(1):24. Epub 2018 Apr 27.

Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.

Background: Although p53 signature, benign-appearing epithelial cells with p53 diffuse expression, is frequently found in the fallopian tubes, the clinical and pathological significance of this lesion in the case of high-grade serous carcinoma (HGSC) patients still remains unclear.

Case Presentation: A 56-year-old woman was referred to the gynecologist on account of abdominal distention. Since radiological and serological workup suggested that her illness was due to advanced ovarian cancer (FIGO Stage IVB), she received neoadjuvant chemotherapy, and the clinical evaluation of the chemotherapeutic response was a partial response. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-018-0702-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923005PMC
April 2018
2 Reads

Fallopian Tube Mucosal Involvement in Cervical Gastric-type Adenocarcinomas: Report of a Series With Discussion of the Distinction From Synchronous In Situ Tubal Lesions.

Am J Surg Pathol 2018 Jun;42(6):813-820

Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.

Cervical gastric-type adenocarcinomas are aggressive non-human papillomavirus-related carcinomas with a propensity for extracervical spread, including unusual sites such as the omentum, peritoneum, and ovary. We report 7 cases of cervical gastric-type adenocarcinoma with fallopian tube involvement predominantly in the form of mucosal colonization without underlying invasion. As far as we are aware, this has not been previously described and this report adds to the literature regarding metastatic neoplasms, which may exhibit tubal mucosal involvement and mimic an in situ lesion at this site. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943166PMC
June 2018
5 Reads

The utility of magnetic resonance imaging in the diagnosis and management of pediatric benign ovarian lesions.

J Pediatr Surg 2018 Oct 31;53(10):2013-2018. Epub 2018 Jan 31.

Division of Pediatric Radiology, The Montreal Children's Hospital of the McGill University Health Centre, Montreal, Quebec, Canada.

Background: The utility of magnetic resonance imaging (MRI) in the diagnosis and management of pediatric ovarian lesions has not been well defined.

Methods: A retrospective review of all girls who underwent MRI evaluation of ovarian masses during the period 2009-2015 was performed. The accuracy of MRI was evaluated by comparing results with surgical findings, pathology reports, and subsequent imaging. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2017.12.028DOI Listing
October 2018
5 Reads

Multilocular cystic leiomyoma of the anterolateral abdominal wall: A case report and literature review.

Medicine (Baltimore) 2017 Dec;96(48):e8971

Institute of Pathology, University Hospital of Erlangen, Erlangen, Germany.

Rationale: Leiomyomas arising from the anterolateral abdominal wall are uncommon, and their pathogenesis remains unknown. We present the 15th case of such a tumor, having this unique tumor morphology, followed by a detailed discussion on disease pathogenesis.

Patient Concerns: A 48-year-old, asymptomatic perimenopausal, multiparous Japanese woman presented with a left-sided pelvic mass. Read More

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http://dx.doi.org/10.1097/MD.0000000000008971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728804PMC
December 2017
19 Reads

Mature cystic teratoma with high proportion of solid thyroid tissue: a controversial case with unusual imaging findings.

J Radiol Case Rep 2017 Jul 31;11(7):20-30. Epub 2017 Jul 31.

Serviço de Anatomia Patológica, Instituto Portugues de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal.

We describe a case of a mature cystic teratoma of the ovary with high proportion of solid thyroid tissue (< 50% of the entire tumor) in a childbearing woman. The patient presented with non-specific abdominal bloating. Pelvic ultrasound and magnetic resonance imaging revealed a complex cystic-solid tumor confined to the left ovary with an anterior fat-containing locus compatible with mature cystic teratoma and a posterior predominantly solid component with low signal intensity on T2-weighted images that was histopatologically diagnosed as benign thyroid tissue. Read More

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http://dx.doi.org/10.3941/jrcr.v11i7.2853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743149PMC
July 2017
13 Reads

Incidental Gynecologic Tract Neoplasms in Women Undergoing Anterior Pelvic Exenteration for Urothelial Carcinoma.

Int J Gynecol Pathol 2019 Jan;38(1):97-102

Department of Pathology, The University of Chicago Medical Center, Chicago, Illinois.

Urothelial carcinoma (UC) invasive into the muscularis propria or tumors unresponsive to treatment are indications for cystectomy. In females, with the goal of achieving complete cancer eradication and for concerns of UC extension into the adjacent pelvic organs, this may also warrant resection of the gynecologic organs. This study is aimed to assess the prevalence of unanticipated gynecologic neoplasms in anterior pelvic exenteration specimens. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000478DOI Listing
January 2019
17 Reads

The developing spectrum of gastric-type cervical glandular lesions.

Pathology 2018 Feb 9;50(2):122-133. Epub 2017 Dec 9.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, United Kingdom.

Adenocarcinoma of the cervix is less common than squamous cell carcinoma, although its relative prevalence is increasing. Oncogenic (high-risk) human papillomavirus (HPV) infection is implicated in the development of approximately 90% of all cervical adenocarcinomas. Of the remaining non-HPV associated tumours, the most frequent is gastric-type adenocarcinoma (GAS), which is recognised by the World Health Organization as a form of mucinous adenocarcinoma of the cervix. Read More

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http://dx.doi.org/10.1016/j.pathol.2017.09.009DOI Listing
February 2018
21 Reads

Elucidating the pathogenesis of synchronous and metachronous tumors in a woman with endometrioid carcinomas using a whole-exome sequencing approach.

Cold Spring Harb Mol Case Stud 2017 Nov 21;3(6). Epub 2017 Nov 21.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.

Synchronous endometrial and ovarian (SEO) carcinomas involve endometrioid neoplasms in both the ovary and uterus at the time of diagnosis. Patients were traditionally classified as having independent primary SEO lesions or as having metastatic endometrioid carcinoma. Recent studies have supported that SEO tumors result from the dissemination of cells from one organ site to another. Read More

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http://dx.doi.org/10.1101/mcs.a001693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701312PMC
November 2017
15 Reads

Long-term Results for Expectant Management of Ultrasonographically Diagnosed Benign Ovarian Teratomas.

Obstet Gynecol 2017 12;130(6):1244-1250

Department of Obstetrics, Gynecology, and Reproduction, Hospital Universitari Dexeus, Barcelona, Spain; the Department of Obstetrics and Gynecology, University of Cagliari, Cagliari, Italy; and the Department of Obstetrics and Gynaecology, Medical School, University of Navarra, Pamplona, Spain.

Objective: To assess the natural history of ultrasonographically diagnosed benign ovarian teratomas in asymptomatic women.

Methods: We conducted a retrospective observational cohort study of 408 women (mean age 36.6 years, range 14-81 years) diagnosed as having an ovarian teratoma by transvaginal ultrasonography (except eight who only had a transabdominal study done) between January 2003 and December 2013 at a single tertiary care institution. Read More

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http://dx.doi.org/10.1097/AOG.0000000000002327DOI Listing
December 2017
31 Reads

Endocrine and neuroendocrine cytopathology.

Minerva Endocrinol 2018 Sep 25;43(3):294-304. Epub 2017 Sep 25.

Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.

Cytology is an easily-accessible, cost-effective, and safe procedure for the initial evaluation of most endocrine/neuroendocrine lesions. Both fine-needle aspiration cytology and exfoliative cytology have shown good sensitivity and specificity in detecting endocrine/neuroendocrine benign proliferations and malignancies. Thanks to its utility for early diagnosis, cytology has contributed to the decline in mortality of endocrine/neuroendocrine neoplasms. Read More

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http://dx.doi.org/10.23736/S0391-1977.17.02744-4DOI Listing
September 2018
8 Reads

Ovarian masses in pediatric patients: a multicenter study of 98 surgical cases in Tunisia.

Gynecol Endocrinol 2018 Mar 23;34(3):243-247. Epub 2017 Sep 23.

a Department of Pediatric Surgery , Hedi Chaker Hospital , Sfax , Tunisia.

Ovarian masses requiring surgical intervention are uncommon in the pediatric population. Our aim is to report results of a multicentric Tunisian study concerning the clinical practice and the management of pediatric ovarian masses and to identify the factors that are associated with ovarian preservation. Between January 2000 and December 2015, 98 pediatric patients (<14 years) were surgically treated for ovarian masses at the five pediatric surgery departments in Tunisia. Read More

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http://dx.doi.org/10.1080/09513590.2017.1381839DOI Listing
March 2018
8 Reads

Different features of the histopathological subtypes of ovarian tumors in pre- and postmenopausal women.

Menopause 2017 Sep;24(9):1028-1032

1Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University, Busan, South Korea 2Paik Institute for Clinical Research, Busan Paik Hospital, Inje University, Busan, South Korea.

Objective: To date, epidemiological evidence has consistently supported a link between ovarian cancer risk and menopause. However, little is known about how menopause status affects the risk of specific histological subtypes of ovarian tumors. We aimed to analyze the differences in various histopathological subtypes of ovarian tumors between pre- and postmenopausal women. Read More

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http://dx.doi.org/10.1097/GME.0000000000000976DOI Listing
September 2017
18 Reads

The Challenge of Ovarian Cancer: Steps Toward Early Detection Through Advanced Signal Processing in Magnetic Resonance Spectroscopy.

Isr Med Assoc J 2017 Aug;19(8):517-525

Department of Oncology-Pathology Karolinska Institute and Medical Radiation Physics and Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden.

Background: Ovarian cancer is a major cause of cancer death among women worldwide, and particularly in Israel. Although the disease at stage IA has 5 year survival rates of over 90%, early detection methods are not sufficiently accurate. Consequently, ovarian cancer is typically diagnosed late, which results in high fatality rates. Read More

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August 2017
24 Reads

Risk of malignancy on suspicion of polyps in menopausal women.

Eur J Obstet Gynecol Reprod Biol 2017 Sep 15;216:138-142. Epub 2017 Jul 15.

CMCO Hospital, Strasbourg University, Teaching Hospital, France.

Improved performances in gynaecological ultrasonography have enabled an increasing number of often asymptomatic endometrial polyps to be detected. Most of these polyps are removed surgically, as a precautionary measure, so as not to miss a case of endometrial cancer. Nonetheless, this management strategy is based solely on the sonographer's judgement and a number of these operations, which are probably of no benefit, could be avoided. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2017.07.013DOI Listing
September 2017
16 Reads

Management of benign ovarian lesions in girls: a trend toward fewer oophorectomies.

Curr Opin Obstet Gynecol 2017 Oct;29(5):289-294

aCenter for Surgical Outcomes Research, The Research Institute bDepartment of Pediatric Surgery, Nationwide Children's Hospital, Columbus, Ohio, USA.

Purpose Of Review: The management of benign ovarian lesions in girls is currently a controversial topic in the pediatric surgical literature. The purpose of this review is to highlight the epidemiology of benign ovarian masses, outline preoperative risk stratification strategies, review the indications and importance of ovary-sparing surgery (OSS), and discuss the impact of management algorithms.

Recent Findings: Efforts across the United States and Canada to promote OSS have improved awareness about the role and safety of OSS for the management of benign ovarian masses in pediatric and adolescent girls. Read More

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http://dx.doi.org/10.1097/GCO.0000000000000400DOI Listing
October 2017
7 Reads

[What haemostatic technique should we use for opportunistic salpingectomy during benign laparoscopic hysterectomy?]

Gynecol Obstet Fertil Senol 2017 Sep 27;45(9):453-459. Epub 2017 Jul 27.

Département de chirurgie gynécologique, Femme-Mère-Enfant hospital, 69000 Lyon-Bron, France; Université Claude-Bernard Lyon-1, EMR 3738, 69000 Lyon, France. Electronic address:

Objective: To compare ovarian function before and after laparoscopic hysterectomy with bilateral salpingectomy for benign lesions with two different systems of haemostasis.

Methods: In this prospective randomized study comparing two types of energy used for coagulation in bilateral salpingectomy (group A: bipolar electric energy, versus group B: ultrasonic advanced energy [Harmonic]), forty consecutive non-menopausal patients undergoing laparoscopic hysterectomy for benign lesions were included. Values of anti-Müllerian hormone (AMH), LH and FSH, antral follicle count (AFC) and ovarian vascularization on bilateral Doppler ultrasound, quality of life (questionnaire) were assessed preoperatively and at 1 and 3 months postoperatively. Read More

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http://dx.doi.org/10.1016/j.gofs.2017.06.017DOI Listing
September 2017
15 Reads

Incidental focal colonic uptake in studies F-FDG PET/CT.

Rev Esp Med Nucl Imagen Mol 2018 Jan - Feb;37(1):15-19. Epub 2017 Jul 24.

Centro Uruguayo de Imagenología Molecular (CUDIM), Montevideo, Uruguay.

Objectives: To assess the frequency of focal colonic uptake as an incidental observation in F-FDG PET/CT studies, and to correlate this finding with histopathological results.

Material And Methods: Out of a total of 3,176 PET/CT studies with F-FDG systematic analysis was carried out on 30 studies in which colonic focal uptake was observed. Patients with known colorectal neoplasia were excluded. Read More

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http://dx.doi.org/10.1016/j.remn.2017.03.012DOI Listing
September 2018
13 Reads

Mucosal Proliferations in Completely Examined Fallopian Tubes Accompanying Ovarian Low-grade Serous Tumors: Neoplastic Precursor Lesions or Normal Variants of Benign Mucosa?

Int J Gynecol Pathol 2018 May;37(3):262-274

Departments of Pathology (R.J.W., C.J.Z., J.T.R.) Epidemiology and Biostatistics (M.A.P.), University of California San Francisco, San Francisco, California.

Malignant transformation of the fallopian tube mucosa, followed by exfoliation of malignant cells onto ovarian and/or peritoneal surfaces, has been implicated as the origin of most pelvic high-grade serous carcinoma. Whether a parallel pathway exists for pelvic low-grade serous tumors [ovarian serous borderline tumor (SBT) and low-grade serous carcinoma (LGSC)] remains to be fully elucidated. The literature is challenging to interpret due to variation in the diagnostic criteria and terminology for cytologically low-grade proliferations of the fallopian tube mucosa, as well as variation in fallopian tube specimen sampling. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000410DOI Listing
May 2018
22 Reads

The NF1 somatic mutational landscape in sporadic human cancers.

Hum Genomics 2017 06 21;11(1):13. Epub 2017 Jun 21.

Division of Cancer and Genetics, Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.

Background: Neurofibromatosis type 1 (NF1: Online Mendelian Inheritance in Man (OMIM) #162200) is an autosomal dominantly inherited tumour predisposition syndrome. Heritable constitutional mutations in the NF1 gene result in dysregulation of the RAS/MAPK pathway and are causative of NF1. The major known function of the NF1 gene product neurofibromin is to downregulate RAS. Read More

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http://dx.doi.org/10.1186/s40246-017-0109-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480124PMC
June 2017
9 Reads

Vesical dermoid: a rare bladder tumour.

BMJ Case Rep 2017 Jun 14;2017. Epub 2017 Jun 14.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Dermoid cysts are benign developmental lesions consisting of tissues of more than one germ cell lineage origin. The urinary bladder is a very rare location of dermoid cysts. We report a case of an 18-year-old woman who presented with suprapubic pain, dysuria and turbid urine. Read More

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http://dx.doi.org/10.1136/bcr-2017-220427DOI Listing
June 2017
10 Reads

Rare Locations of Epidermoid Cyst: Case Reports and Review.

Ethiop J Health Sci 2016 Nov;26(6):595-601

Department of Oralmedicine and radiology, AECS Maaruti College of Dental Sciences & Research Centre, Bangalore.

Background: Epidermoid cysts are benign lesions encountered throughout the body. Eighty percent of epidermoid cyst seen in ovaries and testicles, whereas in head and neck region they account for only 1.6-7. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389081PMC
November 2016
23 Reads

Challenging Salpingectomy as a Risk-Reducing Measure for Ovarian Cancer: Histopathological Analysis of the Tubo-Ovarian Interface in Women Undergoing Risk-Reducing Salpingo-oophorectomy.

Int J Gynecol Cancer 2017 05;27(4):703-707

Departments of *Gynaecological Oncology and †Anatomical Pathology, The Royal Women's Hospital, Parkville, Australia.

Objective: Opportunistic bilateral salpingectomy is now promoted for women at the time of hysterectomy for a benign disease, consequent to the fimbrial end of the fallopian tube emerging as the primary site for carcinogenesis in high-grade serous carcinomas. In high-risk women with an identified germ line mutation, bilateral salpingo-oophorectomy offers the greatest risk reduction for ovarian cancer. Currently, no prospective evidence exists with respect to the effectiveness of opportunistic salpingectomy alone in preventing ovarian cancer. Read More

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http://dx.doi.org/10.1097/IGC.0000000000000954DOI Listing
May 2017
25 Reads

Adnexal masses associated with peritoneal involvement: diagnosis with CT and MRI.

Abdom Radiol (NY) 2017 07;42(7):1975-1992

Lyon 1 University, Villeurbanne, France.

Given the unique intra-peritoneal anatomic location of the adnexa, tubo-ovarian diseases can commonly spread into the peritoneal cavity. Peritoneal seeding may occur in a spectrum of adnexal conditions including infectious diseases, endometriosis, and benign or malignant primary or secondary ovarian tumors. CT is usually the imaging modality on which the concomitant involvement of the peritoneum and the ovary is depicted. Read More

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http://dx.doi.org/10.1007/s00261-017-1089-4DOI Listing
July 2017
27 Reads

Ovarian serous cystadenoma with ectopic adrenal tissue in a 65-year-old patient: A case report.

Int J Surg Case Rep 2017 27;33:89-91. Epub 2017 Feb 27.

Department of Obstetrics and Gynecology, Ege University School of Medicine, Izmir, Turkey.

Introduction: Ectopic adrenal tissue is a very rare entity in adult females, especially in the ovary, and is generally diagnosed incidentally during surgery. Although it can present at various sites during childhood, it becomes atrophic by adulthood due to normally functioning adrenal glands. Patients are predominantly asymptomatic; however, in some cases endocrine symptoms such as hypertension and fasciotruncal obesity due to hormonal activity can be seen or neoplastic transformation can appear. Read More

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http://dx.doi.org/10.1016/j.ijscr.2017.02.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350495PMC
February 2017
16 Reads

BRCA1 expression, proliferative and apoptotic activities in ovarian epithelial inclusions.

J Ovarian Res 2017 Mar 7;10(1):12. Epub 2017 Mar 7.

Department of Pathology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, NB6.408, Dallas, 75390-9072, TX, USA.

Background: The purpose of this study was to examine proliferative and apoptotic activity in relation with BRCA1 expression in ovarian epithelial inclusions (OEIs), the putative precursor lesions of ovarian epithelial cancer (OEC).

Methods: Benign ovaries from 95 patients were examined. Dual immunohistochemical staining for both BRCA1 and MIB-1 were performed to examine the relationship between BRCA1 and MIB-1 in OEI cells. Read More

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http://dx.doi.org/10.1186/s13048-017-0307-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341199PMC
March 2017
7 Reads

A Rare Coexistence of Retrorectal and Ovarian Cysts: A Case Report.

Authors:
Setareh Soltany

Iran Red Crescent Med J 2016 Sep 24;18(9):e31439. Epub 2016 Jul 24.

Cancer Research Center, Department of Surgery, Semnan University of Medical Sciences, Semnan, IR Iran.

Introduction: Retrorectal cysts are rare benign lesions which are frequently diagnosed in middle-aged females. According to their origin and histopathologic features, retrorectal cysts are classified as squamous-lined (dermoid or epidermoid) cysts, postanal gut (tailgut) cysts, and rectal duplications (enteric or enterogenous cysts, enterocystomas). Described in this case report is an extremely unusual patient, a woman who simultaneously had a retrorectal cyst and an ovarian serous cystadenoma in addition to a long history of misdiagnosis and multiple unsuccessful surgeries. Read More

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http://dx.doi.org/10.5812/ircmj.31439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253224PMC
September 2016
5 Reads

The predictive value of sonographic images of follicular lesions - a comparison with nodules unequivocal in FNA - single centre prospective study.

BMC Endocr Disord 2016 Dec 1;16(1):69. Epub 2016 Dec 1.

Department of Morphometry of Endocrine Glands, Chair of Endocrinology, Medical University of Lodz, Sterlinga Str 5, Łódź, 91-425, Poland.

Background: To determine the diagnostic efficacy of ultrasonographic malignancy risk features (UMRFs) in follicular lesions (FL) in a population with low risk of malignancy in FL and to compare it with a similar analysis in a group of patients with unequivocal cytology (UC): benign lesion (BL) or malignant neoplasm (MN).

Methods: Presence of UMRFs (hypoechogenicity, solid echostructure, taller-than-wide shape, pathological vascularization, irregular margins, microcalcifications and macrocalcifications) and their sets were assessed in 322 FL: 202 follicular lesions of undetermined significance (FLUS) and 120 suspicious for follicular neoplasm (SFN) and 300 nodules with UC: 200 BL and 100 MN, subsequently evaluated histopathologically.

Results: Cancers were confirmed in 100% nodules in MN group (89. Read More

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http://dx.doi.org/10.1186/s12902-016-0151-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131422PMC
December 2016
14 Reads

The first case of benign multicystic mesothelioma presenting as a splenic mass.

Ecancermedicalscience 2016 4;10:678. Epub 2016 Oct 4.

Unit of Surgery, AOU S Giovanni di Dio e Ruggi D'Aragona, via S Leonardo, Salerno 84100, Italy.

Multicystic mesothelioma (MM) is a relatively rare tumour arising in the pelvic peritoneum of the tuboovarian region of young woman. Exceptionally, MM occurs on the serosal surfaces of various organs including kidney, bladder, lymph nodes, and liver. We report here the first case of MM wherein a 58-year-old woman with a previous history of endometriosis of the right ovary presented with a large multicystic mass of the spleen. Read More

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http://www.ecancer.org/journal/10/full/678-the-first-case-of
Publisher Site
http://dx.doi.org/10.3332/ecancer.2016.678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102685PMC
October 2016
10 Reads

Clinicopathological Study of Surface Epithelial Tumours of the Ovary: An Institutional Study.

J Clin Diagn Res 2016 Oct 1;10(10):EC01-EC04. Epub 2016 Oct 1.

Professor and HOD, Department of Pathology, Kempegowda Institute of Medical Sciences , Bangalore, Karnataka, India .

Introduction: It is an established fact that tumours of ovary inherit a spectrum of histogenetic background, the variety being more than any other organ. Surface epithelial stromal tumours of ovary being the most common type of ovarian tumours form a complicating and baffling subject in the history of oncology and hence, are an interesting topic for study.

Aim: The aim of this study was to categorize the surface epithelial tumours of ovary into benign, borderline and malignant, to study their clinical and histopathological pattern and to compare their incidences with other studies. Read More

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http://dx.doi.org/10.7860/JCDR/2016/21741.8716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121679PMC
October 2016
8 Reads