1,059 results match your criteria Benign Childhood Epilepsy


Characterization of Anti-seizure Medication Treatment Pathways in Pediatric Epilepsy Using the Electronic Health Record-Based Common Data Model.

Front Neurol 2020 12;11:409. Epub 2020 May 12.

Department of Pediatric, Seoul National University Children's Hospital, Seoul, South Korea.

The purpose of this pilot study was to analyze treatment pathways of pediatric epilepsy using the common data model (CDM) based on electronic health record (EHR) data. We also aimed to reveal whether CDM analysis was feasible and applicable to epilepsy research. We analyzed the treatment pathways of pediatric epilepsy patients from our institute who underwent antiseizure medication (ASM) treatment for at least 2 years, using the Observational Medical Outcomes Partnership (OMOP)-CDM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2020.00409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235379PMC

Nonlinear Analysis of Visually Normal EEGs to Differentiate Benign Childhood Epilepsy with Centrotemporal Spikes (BECTS).

Sci Rep 2020 May 21;10(1):8419. Epub 2020 May 21.

Computational Health Informatics Program, Boston Children's Hospital, Boston, USA.

Childhood epilepsy with centrotemporal spikes, previously known as Benign Epilepsy with Centro-temporal Spikes (BECTS) or Rolandic Epilepsy, is one of the most common forms of focal childhood epilepsy. Despite its prevalence, BECTS is often misdiagnosed or missed entirely. This is in part due to the nocturnal and brief nature of the seizures, making it difficult to identify during a routine electroencephalogram (EEG). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-65112-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242341PMC

[Research advances in multimodal magnetic resonance for cognitive impairment in children with benign childhood epilepsy with centrotemporal spikes].

Zhongguo Dang Dai Er Ke Za Zhi 2020 May;22(5):528-532

Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

Cognitive impairment in children with benign childhood epilepsy with centrotemporal spikes (BECT) has complex etiologies and is closely associated abnormal neural networks. Multimodal magnetic resonance imaging of brain structure and function is a powerful tool for studying abnormal neural networks of cognitive impairment in epilepsy and can explore the pathogenesis of cognitive impairment in epilepsy at the level of brain structure and function by analyzing the imaging features of brain structure and function. This article reviews the research advances in multimodal magnetic resonance for cognitive impairment in children with BECT. Read More

View Article

Download full-text PDF

Source

Benign epilepsy with centrotemporal spikes: Is there a thalamocortical network dysfunction present?

Seizure 2020 May 5;79:44-48. Epub 2020 May 5.

Department of Pediatric Neurology, Medical Faculty of Gazi University, Ankara, Turkey. Electronic address:

Introduction: Benign epilepsy of childhood with centrotemporal spikes (BECTS) is one of the most frequently seen epileptic syndromes in childhood. It is characterized by centrotemporal spikes (CTS) on electroencephalography (EEG) that are typically activated by drowsiness and stage N2 sleep. The location, frequency, and amplitude of the spikes may vary in different EEG records of the same patient, supporting the presence of a global pathology rather than a focal one. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2020.04.003DOI Listing

Calcifying pseudoneoplasm of the neuroaxis presenting with refractory seizures: Case report and literature review.

J Clin Neurosci 2020 May 6. Epub 2020 May 6.

Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare benign lesions that can arise anywhere within the central nervous system. The etiology of these lesions remains unknown and diagnosis is made on pathohistological analysis. We present the case of a 35-year-old male patient with a history of epilepsy since childhood who was evaluated for refractory seizures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jocn.2020.05.001DOI Listing

Clinical Features and Evaluation in Terms of Prophylaxis of Patients With Febrile Seizures.

Authors:
Betül Kılıç

Sisli Etfal Hastan Tip Bul 2019 27;53(3):276-283. Epub 2019 Aug 27.

Department of Pediatric Neurology, Health Sciences University Faculty of Medicine, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.

Objectives: Febrile seizures are the most common seizure type of childhood, and prognosis is usually good. Many factors that increase the risk of recurrence and develop epilepsy have been identified. This study aims to determine the clinical characteristics of patients who were admitted with the febrile seizure, and determine the outcomes of the treatment, and the risk factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14744/SEMB.2019.30633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192276PMC

Novel variant in CHRNA4 with benign childhood epilepsy with centrotemporal spikes and contribution to precise medicine.

Mol Genet Genomic Med 2020 Apr 28:e1264. Epub 2020 Apr 28.

Department of Pediatrics, Maternal and Child Health Hospital of Chenzhou city, Chenzhou, China.

Background: Benign childhood epilepsy with centrotemporal spikes (BECTS) or benign rolandic epilepsy is the most common epileptic syndrome in school-age children. Genetics is an important factor in BECTS pathogenesis, and <10 genes were associated with BECTS. This study aimed to identify novel genetic causes of BECTS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mgg3.1264DOI Listing

Novel and de novo point and large microdeletion mutation in PRRT2-related epilepsy.

Brain Behav 2020 May 31;10(5):e01597. Epub 2020 Mar 31.

Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.

Background: Point and copy number variant mutations in the PRRT2 gene have been identified in a variety of paroxysmal disorders and different types of epilepsy. In this study, we analyzed the phenotypes and PRRT2-related mutations in Chinese epilepsy children.

Methods: A total of 492 children with epilepsy were analyzed by whole exome sequencing (WES) and low-coverage massively parallel CNV sequencing (CNV-seq) to find the single nucleotide variants and copy number variations (CNVs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/brb3.1597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218244PMC

Electrical status epilepticus in sleep affects intrinsically connected networks in patients with benign childhood epilepsy with centrotemporal spikes.

Epilepsy Behav 2020 May 25;106:107032. Epub 2020 Mar 25.

Radiology Department of Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Renmin Middle Road 253rd, Guangzhou 510220, China.

Background: Although outcomes of benign childhood epilepsy with centrotemporal spikes (BECTS) are frequently excellent, some atypical forms of BECTS, especially electrical status epilepticus in sleep (ESES), are characterized by worse outcomes and negative impacts on cognitive development.

Methods: To explore specific ESES-related brain networks in patients with BECTS, we used resting-state functional magnetic resonance imaging (fMRI) to scan patients with BECTS with ESES (n = 9), patients with BECTS without ESES (n = 17), and healthy controls (n = 36). Unbiased seed-based whole-brain functional connectivity (FC) was adopted to explore the connectivity mode of three resting-state cerebral networks: the default mode network (DMN), salience network (SN), and central executive network (CEN). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2020.107032DOI Listing

Cognitive Function in Genetic Generalized Epilepsies: Insights From Neuropsychology and Neuroimaging.

Front Neurol 2020 10;11:144. Epub 2020 Mar 10.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom.

Genetic generalized epilepsies (GGE), previously called idiopathic generalized epilepsies, constitute about 20% of all epilepsies, and include childhood absence epilepsy, juvenile absence epilepsy, juvenile myoclonic epilepsy, and epilepsy with generalized tonic-clonic seizures alone (CAE, JAE, JME, and GGE-GTCS, respectively). GGE are characterized by high heritability, likely underlain by polygenetic mechanisms, which may relate to atypical neurodevelopmental trajectories. Age of onset ranges from pre-school years, for CAE, to early adulthood for GGE-GTCS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2020.00144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076110PMC

Electroencephalographic abnormalities are correlated with cognitive deficits in children with benign childhood epilepsy with centrotemporal spikes: A clinical study of 61 cases.

Epilepsy Behav 2020 May 13;106:107012. Epub 2020 Mar 13.

Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing 100053, China. Electronic address:

Objective: The objective of this study was to explore the effect of spikes on cognition in patients with benign childhood epilepsy with centrotemporal spikes (BECTS) and to identify electroencephalography (EEG) markers enabling early detection of cognitive impairment.

Methods: Sixty-one children with BECTS diagnoses and 60 age- and education-matched healthy controls were enrolled. Four-hour EEG recordings were analyzed for each patient to check for interictal spikes, high-frequency oscillations (HFOs), nondipole spikes, and other atypical EEG features and to examine the spike-wave index of nonrapid eye movement (NREM) sleep. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2020.107012DOI Listing

[Prognosis of benign childhood epilepsy with centrotemporal spikes: clinical utility of objective diagnostic criteria].

Rev Neurol 2020 Mar;70(6):206-212

Hospital Torrecárdenas, 04009 Almería, España.

Introduction: Studies about childhood epilepsy with centrotemporal spikes (CECTS), most of them retrospective, include patients with highly heterogeneous features.

Aim: To investigate the prognostic value of objective diagnostic criteria for CECTS applied at six month of evolution of epilepsy.

Patients And Methods: All patients with one or more unprovoked epileptic seizures (n = 827) were prospectively included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.33588/rn.7006.2019357DOI Listing

Multisystem burden of neurofibromatosis 1 in Denmark: registry- and population-based rates of hospitalizations over the life span.

Genet Med 2020 Feb 28. Epub 2020 Feb 28.

Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark.

Purpose: The aim was to assess lifetime risk for hospitalization in individuals with neurofibromatosis 1 (NF1).

Methods: The 2467 individuals discharged with a diagnosis indicating NF1 or followed in a clinical center for NF1 were matched to 20,132 general population comparisons. Based on diagnoses in 12 main diagnostic groups and 146 subcategories, we calculated rate ratios (RRs), absolute excess risks (AERs), and hazard ratios for hospitalizations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41436-020-0769-6DOI Listing
February 2020

[Symptomatic epilepsy with Panayiotopoulos-like onset: the importance of neuroimaging].

Rev Neurol 2020 Feb;70(4):134-138

Hospital Universitario Central de Asturias, Oviedo, España.

Introduction: Panayiotopoulos syndrome (PS) is a common form of epilepsy in childhood that is classified as one of the benign idiopathic focal epilepsies. There is no consensus on the indication of neuroimaging in the presence of an electroclinical picture consistent with this disorder. Two cases are presented that began with an electroclinical pattern compatible with PS and in which alterations in the occipital structure were finally detected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.33588/rn.7004.2019493DOI Listing
February 2020

Mapping the Effect of Interictal Epileptic Activity Density During Wakefulness on Brain Functioning in Focal Childhood Epilepsies With Centrotemporal Spikes.

Front Neurol 2019 19;10:1316. Epub 2019 Dec 19.

Neurology Unit, OCB Hospital, AOU Modena, Modena, Italy.

Childhood epilepsy with centrotemporal spikes (CECTS) is the most common type of "self-limited focal epilepsies." In its typical presentation, CECTS is a condition reflecting non-lesional cortical hyperexcitability of rolandic regions. The benign evolution of this disorder is challenged by the frequent observation of associated neuropsychological deficits and behavioral impairment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2019.01316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930928PMC
December 2019

Phenotypic spectrum and genetics of SCN2A-related disorders, treatment options, and outcomes in epilepsy and beyond.

Epilepsia 2019 12;60 Suppl 3:S59-S67

Paediatric Neurosciences Research Group, Royal Hospital for Children & School of Medicine, University of Glasgow, Glasgow, UK.

Pathogenic variants in the SCN2A gene are associated with a variety of neurodevelopmental phenotypes, defined in recent years through multicenter collaboration. Phenotypes include benign (self-limited) neonatal and infantile epilepsy and more severe developmental and epileptic encephalopathies also presenting in early infancy. There is increasing evidence that an important phenotype linked to the gene is autism and intellectual disability without epilepsy or with rare seizures in later childhood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.14935DOI Listing
December 2019

Phenotypic and genetic spectrum of SCN8A-related disorders, treatment options, and outcomes.

Epilepsia 2019 12;60 Suppl 3:S77-S85

Danish Epilepsy Center, Dianalund, Denmark.

Pathogenic variants in SCN8A have originally been described in patients with developmental and epileptic encephalopathy (DEE). However, recent studies have shown that SCN8A variants can be associated with a broader phenotypic spectrum, including the following: (1) Patients with early onset, severe DEE, developing severe cognitive and motor regression, pyramidal/extrapyramidal signs, and cortical blindness. Severe SCN8A-DEE is characterized by intractable seizures beginning in the first months of life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.16319DOI Listing
December 2019

Epilepsy syndromes of childhood with sleep activation: Insights from functional imaging.

Eur J Paediatr Neurol 2020 Jan 17;24:58-60. Epub 2019 Dec 17.

Department of Pediatric Neurology, CHU d'Angers and Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), Université d'Angers, France. Electronic address:

In epilepsy syndromes of childhood with sleep activation, defined as the spectrum of epileptic conditions going from classical benign childhood epilepsy with centrotemporal spikes (BECTS) to epileptic encephalopathy (EE) with continuous spike and waves during slow-wave sleep (CSWS) including Landau-Kleffner syndrome (LKS), a lot of functional imaging studies have been performed so far, leading to results that are not always consistent, related to the technique of neuroimaging performed and to the variability of the clinical phenotype. Most consistent findings are, depending of the method used, activations or increased regional glucose metabolism in the epileptogenic regions, and deactivations, hypometabolism or decreased functional connectivity in cortical regions that belong to the default mode network. Functional changes are either transitory, temporally related to the occurrence of interictal epileptiform discharges (IED), or permanent, persisting across IED-free periods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejpn.2019.12.006DOI Listing
January 2020

[Electroclinical characteristics of epilepsy children with midline epileptiform discharges related epileptic negative myoclonus as the first symptom].

Zhonghua Er Ke Za Zhi 2019 Dec;57(12):943-949

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To investigate the electroclinical findings in epilepsy children with epileptic negative myoclonus (ENM) restricted to the lower limb as the first seizure type. Each retrieved electroencephalogram record performed between March 2011 and March 2018 at the Department of Pediatrics of Peking University First Hospital was searched with "midline" . There were 302 records of 175 patients with "benign" or "functional" midline spikes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.12.009DOI Listing
December 2019

SCN1A variants from bench to bedside-improved clinical prediction from functional characterization.

Hum Mutat 2020 Feb 28;41(2):363-374. Epub 2019 Nov 28.

The Paediatric Neurosciences Research Group, Royal Hospital for Children, Glasgow, UK.

Variants in the SCN1A gene are associated with a wide range of disorders including genetic epilepsy with febrile seizures plus (GEFS+), familial hemiplegic migraine (FHM), and the severe childhood epilepsy Dravet syndrome (DS). Predicting disease outcomes based on variant type remains challenging. Despite thousands of SCN1A variants being reported, only a minority has been functionally assessed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.23943DOI Listing
February 2020

Clinical and genetic aspect of 30 tunisian families with febrile seizures.

Tunis Med 2019 Apr;97(4):525-532

Background: FS are the most benign occasional seizures in childhood. Little is known about the long term follow up.  Aim: To describe a long term follow-up of FS in Tunisian families. Read More

View Article

Download full-text PDF

Source

Paroxysmal non-epileptic events in infancy: five cases with typical features.

Epileptic Disord 2019 Oct;21(5):458-462

Department of Paediatrics, Medical School, University of Pecs, Hungary.

The differential diagnosis of paroxysmal non-epileptic events in early childhood is one of the most challenging tasks in paediatrics, and may be difficult even for specialized child neurologists. Parents are usually concerned by every unusual movement of their children and consult paediatric general practitioners immediately. We investigated five infants/toddlers (aged 1-30 months) referred by their general practitioners with a suspicion of epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/epd.2019.1098DOI Listing
October 2019

The natural history of seizures and neuropsychiatric symptoms in childhood epilepsy with centrotemporal spikes (CECTS).

Epilepsy Behav 2020 Feb 20;103(Pt A):106437. Epub 2019 Oct 20.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: Childhood epilepsy with centrotemporal spikes (CECTS) (formally benign epilepsy with centrotemporal spikes, BECTS) is a common childhood epilepsy syndrome characterized by psychiatric, behavioral, and cognitive abnormalities and self-limited seizures. Although CECTS is one of the most well-characterized electroclinical epilepsy syndromes, the natural history of neuropsychiatric outcomes is poorly understood. We report the psychiatric, behavioral, and cognitive profiles over the course of disease from a large, prospectively-enrolled, longitudinal cohort of children with CECTS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2019.07.038DOI Listing
February 2020

Dysmature superficial white matter microstructure in developmental focal epilepsy.

Brain Commun 2019 19;1(1):fcz002. Epub 2019 Jun 19.

Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

Benign epilepsy with centrotemporal spikes is a common childhood epilepsy syndrome that predominantly affects boys, characterized by self-limited focal seizures arising from the perirolandic cortex and fine motor abnormalities. Concurrent with the age-specific presentation of this syndrome, the brain undergoes a developmentally choreographed sequence of white matter microstructural changes, including maturation of association u-fibres abutting the cortex. These short fibres mediate local cortico-cortical communication and provide an age-sensitive structural substrate that could support a focal disease process. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/braincomms/article/doi/10.1093/brai
Publisher Site
http://dx.doi.org/10.1093/braincomms/fcz002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777514PMC
June 2019
6 Reads

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.

Acta Neuropathol 2020 01 28;139(1):193-209. Epub 2019 Sep 28.

Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

The "isomorphic subtype of diffuse astrocytoma" was identified histologically in 2004 as a supratentorial, highly differentiated glioma with low cellularity, low proliferation and focal diffuse brain infiltration. Patients typically had seizures since childhood and all were operated on as adults. To define the position of these lesions among brain tumours, we histologically, molecularly and clinically analysed 26 histologically prototypical isomorphic diffuse gliomas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-019-02078-wDOI Listing
January 2020
3 Reads

Risk factors for recurrence after drug withdrawal in childhood epilepsy.

Brain Dev 2020 Jan 11;42(1):35-40. Epub 2019 Sep 11.

Department of Pediatric Neurology, Ankara Children's Hospital Hematology-Oncology Research and Training Hospital, Ankara, Turkey.

Background: Several studies have been conducted to determine the risk of recurrence after withdrawal of antiepileptic drugs (AEDs) in recent years. There is no consensus concerning the circumstances affecting discontinuation of AEDs. This study was designed to determine the recurrence rate of epilepsy after withdrawal of AEDs and the risk factors related with recurrence. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03877604193026
Publisher Site
http://dx.doi.org/10.1016/j.braindev.2019.08.012DOI Listing
January 2020
3 Reads

Development of Ontology for Self-limited Epilepsy with Centrotemporal Spikes and Application of Data Mining Algorithms to Identify New Subtypes.

Isr Med Assoc J 2019 Jul;21(7):503

Department of Pediatric Neurology, Dana-Dwek Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Benign rolandic epilepsy or benign childhood epilepsy with centrotemporal spikes (BCECTS) is a common childhood epileptic syndrome. The syndrome resolves in adolescence, but 1-7% of patients have an atypical presentation, some of which require aggressive medical treatment. Early treatment may prevent complications and neurocognitive deterioration. Read More

View Article

Download full-text PDF

Source
July 2019
6 Reads

Reduced thalamic volume is strongly associated with electrical status epilepticus in sleep.

Acta Neurol Belg 2019 Aug 27. Epub 2019 Aug 27.

Department of Pediatric Neurology, Ankara Children's Hematology-Oncology Training and Research Hospital, Dıskapı, 06110, Ankara, Turkey.

To identify the relationship between thalamic volume and electrical status epilepticus in sleep (ESES). We analyzed subcortical gray matter volumes in patients with an ESES pattern on their electroencephalographs. All magnetic resonance imaging scans were considered within normal limits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13760-019-01202-7DOI Listing

Panayiotopoulos syndrome and Gastaut syndrome are distinct entities in terms of neuropsychological findings.

Epilepsy Behav 2019 10 6;99:106447. Epub 2019 Aug 6.

Istanbul University, Istanbul Faculty of Medicine, Department of Neurology, Istanbul, Turkey.

Background: Although the courses of self-limited focal epilepsies of childhood are considered as benign, a handful of studies suggested that these children may suffer from cognitive problems. Implementing tailor-made educational strategies would aid these children to reach their full potentials. Therefore, it is crucial to understand and differentiate the complete neuropsychological and behavioral profiles of these rather common syndromes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2019.106447DOI Listing
October 2019
2 Reads

Network analysis of prospective brain development in youth with benign epilepsy with centrotemporal spikes and its relationship to cognition.

Epilepsia 2019 09 26;60(9):1838-1848. Epub 2019 Jul 26.

Department of Neurology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.

Objective: Benign epilepsy with centrotemporal spikes (BECTS) is the most common childhood idiopathic localization-related epilepsy syndrome. BECTS presents normal routine magnetic resonance imaging (MRI); however, quantitative analytic techniques have captured subtle cortical and subcortical magnetic resonance anomalies. Network science, including graph theory (GT) analyses, facilitates understanding of brain covariance patterns, potentially informing in important ways how this common self-limiting epilepsy syndrome may impact normal patterns of brain and cognitive development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.16290DOI Listing
September 2019
6 Reads
4.571 Impact Factor

Propofol-induced refractory status epilepticus at remission age in benign epilepsy with centrotemporal spikes: A case report and literature review.

Medicine (Baltimore) 2019 Jul;98(27):e16257

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Rationale: Benign epilepsy with centrotemporal spikes (BECTS) is one of the most common forms of childhood epilepsy, which is expected to resolve before 16 years of age, with mild effects on the cognitive or behavioral functions in adulthood. This study aims to report the first propofol-induced refractory status epilepticus (SE) in patients with BECTS after 16 years of age, and to review SE in BECTS or induced by propofol.

Patient Concern: A 16-year-old Chinese girl, who was diagnosed with BECTS at the age of 2 years, developed refractory SE induced by propofol administered during the maintenance stage of general anesthesia during a plastic surgery procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000016257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635254PMC
July 2019
7 Reads

Cognitive profile in BECTS treated with levetiracetam: A 2-year follow-up.

Epilepsy Behav 2019 08 25;97:187-191. Epub 2019 Jun 25.

Department of Pediatrics, University of L'Aquila, L'Aquila, Italy.

Introduction: Benign epilepsy with centrotemporal spikes (BECTS) is a common epileptic syndrome in childhood, characterized by brief and infrequent partial motor seizures, with or without generalization and mostly recurring during sleep. Because of its favorable efficacy, tolerability, and safety profile, levetiracetam (LEV) monotherapy is often administered in these patients. Long-term effects of LEV therapy and its influence on cognitive functions remain controversial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2019.05.046DOI Listing
August 2019
6 Reads

The role of sleep-related cognitive functions in the spectrum of benign epilepsy with centro-temporal spikes.

Eur J Pediatr 2019 Aug 21;178(8):1129-1137. Epub 2019 Jun 21.

Department of Pediatric Neurology and Developmental Medicine, University of Basel Children's Hospital, Basel, Switzerland.

Heterogeneous cognitive deficits have been described in the spectrum of benign epilepsy with centro-temporal spikes, which strongly correlate with the intensity of interictal epileptiform discharges and its spreading, in particular during sleep, mostly within the perisylvian cognitive network. The aim of this review is to discuss current findings regarding the connection between sleep alterations and cognitive function in the spectrum of benign epilepsy with centro-temporal spikes. A longer sleep onset latency is the only evident sleep macrostructure alteration reported in the spectrum of benign epilepsy with centro-temporal spikes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-019-03413-9DOI Listing
August 2019
9 Reads

KCNQ2 mutations in childhood nonlesional epilepsy: Variable phenotypes and a novel mutation in a case series.

Mol Genet Genomic Med 2019 07 14;7(7):e00816. Epub 2019 Jun 14.

Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Background: Epilepsy caused by a KCNQ2 gene mutation usually manifests as neonatal seizures during the first week of life. The genotypes and phenotypes of KCNQ2 mutations are noteworthy.

Methods: The KCNQ2 sequencings done were selected from 131 nonconsanguineous pediatric epileptic patients (age range: 2 days to 18 years) with nonlesional epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mgg3.816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625149PMC
July 2019
5 Reads

Delayed cortical maturation at the centrotemporal brain regions in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS).

Epilepsy Res 2019 08 18;154:124-131. Epub 2019 May 18.

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhonpathom, 73170, Thailand. Electronic address:

Benign childhood epilepsy with centrotemporal spikes (BCECTS) is an epilepsy syndrome commonly found in child and adolescent. Although the prognosis is mostly favorable as long as the seizure is well controlled. However, they are often suffering from the cognitive and behavioral problems which might be the consequences of the initial insults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2019.05.003DOI Listing
August 2019
12 Reads

Clinical Significance of Incidental Rolandic Spikes in Children With Absence Epilepsy.

J Child Neurol 2019 10 22;34(11):631-638. Epub 2019 May 22.

1 Department of Pediatrics, Division of Neurology, BC Children's Hospital, Vancouver, BC, Canada.

Purpose: Absence epilepsy and benign epilepsy of childhood with central temporal spikes are common childhood epilepsy syndromes. Although 3-Hz generalized spike-wave discharges are almost always associated with absence seizures, rolandic spikes can be present in individuals without rolandic seizures. The co-occurrence of 3-Hz generalized spike-wave and rolandic spikes is very rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0883073819848639DOI Listing
October 2019
7 Reads

Clinical Pearls and Advances in Molecular Researches of Epilepsy-Associated Tumors.

J Korean Neurosurg Soc 2019 May 1;62(3):313-320. Epub 2019 May 1.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, Korea.

Brain tumors are the second most common type of structural brain lesion that causes chronic epilepsy. Patients with low-grade brain tumors often experience chronic drug-resistant epilepsy starting in childhood, which led to the concept of long-term epilepsy-associated tumors (LEATs). Dysembryoplastic neuroepithelial tumor and ganglioglioma are representative LEATs and are characterized by young age of onset, frequent temporal lobe location, benign tumor biology, and chronic epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3340/jkns.2019.0033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514318PMC
May 2019
9 Reads

Epileptic negative myoclonus restricted to lower limbs in benign childhood focal epilepsy with vertex spikes.

Eur J Neurol 2019 10 12;26(10):1318-1326. Epub 2019 Jul 12.

Department of Pediatrics, Peking University First Hospital, Beijing, China.

Background And Purpose: The aim was to determine the electroclinical findings in benign childhood focal epilepsy with vertex spikes (BEVS) with epileptic negative myoclonus (ENM) restricted to the lower limbs.

Methods: The electroencephalogram database of Peking University First Hospital and medical records of patients with BEVS and ENM restricted to the lower limbs were reviewed.

Results: Twenty-seven patients with BEVS had ENM restricted to the lower limbs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ene.13982DOI Listing
October 2019
8 Reads

Autism spectrum disorder and attention-deficit/hyperactivity disorder-related symptoms in benign childhood epilepsy with centrotemporal spikes: A prospective case-control study.

Epilepsy Behav 2019 06 23;95:61-64. Epub 2019 Apr 23.

Department of Pediatric Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Background: Benign childhood epilepsy with centrotemporal spikes (BECTS), one of the most common idiopathic epilepsy syndromes in children, has been associated with neuropsychological problems.

Purpose: The objective of this study was to investigate the frequency of symptoms related to comorbid neurodevelopmental disorders, the autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in children with typical BECTS, and to identify corresponding risk factors.

Methods: Children and adolescents with typical BECTS aged 6-16 years were included in the study period from January 1, 2017, to December 31, 2017. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15255050193013
Publisher Site
http://dx.doi.org/10.1016/j.yebeh.2019.03.044DOI Listing
June 2019
19 Reads

Concomitance of benign epilepsy with centrotemporal spikes and childhood absence epilepsy: an unusual case.

Neurol Sci 2019 Sep 23;40(9):1979-1980. Epub 2019 Apr 23.

Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-019-03893-5DOI Listing
September 2019
2 Reads

Dysfunctional white-matter networks in medicated and unmedicated benign epilepsy with centrotemporal spikes.

Hum Brain Mapp 2019 07 1;40(10):3113-3124. Epub 2019 Apr 1.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.

Benign epilepsy with centrotemporal spikes (BECT) is the most common childhood idiopathic focal epilepsy syndrome, which characterized with white-matter abnormalities in the rolandic cortex. Although diffusion tensor imaging research could characterize white-matter structural architecture, it cannot detect neural activity or white-matter functions. Recent studies demonstrated the functional organization of white-matter by using functional magnetic resonance imaging (fMRI), suggesting that it is feasible to investigate white-matter dysfunctions in BECT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hbm.24584DOI Listing
July 2019
8 Reads

Scalp recorded spike ripples predict seizure risk in childhood epilepsy better than spikes.

Brain 2019 05;142(5):1296-1309

Massachusetts General Hospital, Department of Neurology, Boston, MA, USA.

In the past decade, brief bursts of fast oscillations in the ripple range have been identified in the scalp EEG as a promising non-invasive biomarker for epilepsy. However, investigation and clinical application of this biomarker have been limited because standard approaches to identify these brief, low amplitude events are difficult, time consuming, and subjective. Recent studies have demonstrated that ripples co-occurring with epileptiform discharges ('spike ripple events') are easier to detect than ripples alone and have greater pathological significance. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/brain/advance-article/doi/10.1093/b
Publisher Site
http://dx.doi.org/10.1093/brain/awz059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487332PMC
May 2019
36 Reads

Levetiracetam versus carbamazepine in treatment of rolandic epilepsy.

Epilepsy Behav 2019 05 15;94:1-8. Epub 2019 Mar 15.

Cobel Darou, Tehran, Iran. Electronic address:

Purpose: The aim of the current study was to systematically review the literature to compare the efficacy of levetiracetam (LEV) with that of carbamazepine (CBZ) to control seizures and reduce the burden of interictal epileptiform discharges in children with rolandic epilepsy (RE) and also to compare their tolerability.

Methods: We searched the electronic database PubMed on January 9, 2019 for original articles that included the following English-language search terms in the title: "Rolandic epilepsy" OR "benign childhood epilepsy with centrotemporal spikes" since 2000. We concentrated our review on three main areas: 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2019.02.009DOI Listing
May 2019
6 Reads

Beta oscillations in the sensorimotor cortex correlate with disease and remission in benign epilepsy with centrotemporal spikes.

Brain Behav 2019 03 20;9(3):e01237. Epub 2019 Feb 20.

Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.

Introduction: Benign epilepsy with centrotemporal spikes (BECTS) is a common form of childhood epilepsy with the majority of those afflicted remitting during their early teenage years. Seizures arise from the lower half of the sensorimotor cortex of the brain (e.g. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/brb3.1237
Publisher Site
http://dx.doi.org/10.1002/brb3.1237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422718PMC
March 2019
18 Reads

[Continuous spike-waves during slow-wave sleep: Experience during 20 years].

An Pediatr (Barc) 2019 Sep 14;91(3):180-188. Epub 2019 Feb 14.

Sección de Neuropediatría, Hospital Materno Infantil Gregorio Marañón, Madrid, España.

Introduction: Continuous spikes and waves during slow sleep (CSWS) is an EEG pattern that appears during childhood, and is often associated with cognitive impairment. It can appear in the course of epileptic syndromes, as well as in benign epilepsy. The aim of this study is to analyse epidemiological and clinical characteristic of patients with CSWS, in order to describe possible predictive factors in their outcome. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S16954033193002
Publisher Site
http://dx.doi.org/10.1016/j.anpedi.2018.12.016DOI Listing
September 2019
37 Reads

Stridor as initial presentation of rolandic epilepsy.

Int J Pediatr Otorhinolaryngol 2019 Apr 30;119:183-184. Epub 2019 Jan 30.

Department of Otorhinolaryngology, Centro Hospitalar Vila Nova de Gaia/Espinho, Unidade 1, Serviço de Otorrinolaringologia, Pavilhão Feminino, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal.

The authors present the case of a 5-year-old girl referred to our institution due to several episodes of nocturnal stridor with ocular retroversion and parental notion of apnea. She has been previously submitted to adenotonsillectomy. Due to symptoms worsening she was referred to our hospital. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01655876193005
Publisher Site
http://dx.doi.org/10.1016/j.ijporl.2019.01.040DOI Listing
April 2019
36 Reads

Changes in background electroencephalographic activity in benign childhood epilepsy with centrotemporal spikes after oxcarbazepine treatment: a standardized low-resolution brain electromagnetic tomography (sLORETA) study.

BMC Neurol 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.

Background: Several neuroimaging studies have reported neurophysiological alterations in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS). However, reported outcomes have been inconsistent, and the progression of these changes in the brain remains unresolved. Moreover, background electroencephalography (EEG) in cases of BCECTS has not been performed often. Read More

View Article

Download full-text PDF

Source
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
Publisher Site
http://dx.doi.org/10.1186/s12883-018-1228-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317234PMC
January 2019
35 Reads

De novo absence status epilepticus in three paediatric patients: a new idiopathic epilepsy syndrome?

Epileptic Disord 2018 Dec;20(6):502-507

Hospital de Pediatría "La madre y el Niño", Formosa, Argentina.

Absence status epilepticus (ASE) is a prolonged generalized absence seizure that usually lasts for hours and can even last for days. The main symptom is the altered content of consciousness while the patient may be alert and partly responsive. We describe the electroclinical features, treatment, and evolution of three paediatric patients with de novo ASE with an excellent response to valproic acid (VPA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/epd.2018.1008DOI Listing
December 2018
17 Reads