1,010 results match your criteria Benign Childhood Epilepsy


De novo absence status epilepticus in three paediatric patients: a new idiopathic epilepsy syndrome?

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Hospital de Pediatría "La madre y el Niño", Formosa, Argentina.

Absence status epilepticus (ASE) is a prolonged generalized absence seizure that usually lasts for hours and can even last for days. The main symptom is the altered content of consciousness while the patient may be alert and partly responsive. We describe the electroclinical features, treatment, and evolution of three paediatric patients with de novo ASE with an excellent response to valproic acid (VPA). Read More

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http://dx.doi.org/10.1684/epd.2018.1008DOI Listing
December 2018

Co-existence of Rolandic and 3 Hz Spike-Wave Discharges on EEG in Children with Epilepsy.

Can J Neurol Sci 2018 Dec 3:1-7. Epub 2018 Dec 3.

1Department of Pediatrics, Division of Neurology,BC Children's Hospital,Vancouver, British Columbia,Canada.

Objective: Benign epilepsy of childhood with central temporal spikes (BECTS) and absence epilepsy are common epilepsy syndromes in children with similar age of onset and favorable prognosis. However, the co-existence of the electrocardiogram (EEG) findings of rolandic spike and 3 Hz generalized spike-wave (GSW) discharges is extremely rare, with few cases reported in the literature. Our objective was to characterize the EEG findings of these syndromes in children in our center and review the electro-clinical features. Read More

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http://dx.doi.org/10.1017/cjn.2018.364DOI Listing
December 2018
1 Read

[Clinical characteristics and genetic features of benign infantile epilepsy with PRRT2 mutation].

Zhonghua Er Ke Za Zhi 2018 Nov;56(11):818-823

Department of Neurology, National Center for Children's Health (Beijing) , Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.

To summarize the detailed clinical characteristics and genetic features of benign infantile epilepsy with PRRT2 mutation, in order to improve the understanding of the disease. The clinical data and genetic results of 40 benign infantile epilepsy patients with PRRT2 mutation who were diagnosed and treated in the neurology department of National Center for Children's Health (Beijing) , Beijing Children's Hospital affiliated to Capital Medical University from January 2002 to October 2017 and their affected family members were analyzed. Forty benign infantile epilepsy patients were recruited for this study, with 18 males and 22 females. Read More

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November 2018
4 Reads

Benign rolandic epilepsy of childhood and central auditory processing disorder: A noncasual neurophysiological association.

Epilepsy Behav 2018 Dec 26;89:55-58. Epub 2018 Oct 26.

Pediatric Neurology Department, Hospital Pequeno Príncipe, Curitiba, PR, Brazil. Electronic address:

Purpose: The purpose of this study was to demonstrate the association between benign rolandic epilepsy of childhood (BREC) and central auditory processing disorders (CAPDs) and to test the hypothesis that an early onset of BREC could be associated with more cases of CAPD.

Method: This study has a retrospective cross-sectional design conducted from January 2006 to January 2016 including 93 patients with BREC and without intellectual disability, dyslexia, and attention-deficit hyperactivity disorders. All patients were evaluated for central auditory processing (CAP), and its presence or absence was compared with age of seizure onset. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.06.039DOI Listing
December 2018
6 Reads

Network characteristics in benign epilepsy with centro-temporal spikes patients indicating defective connectivity during spindle sleep: A partial directed coherence study of EEG signals.

Clin Neurophysiol 2018 Nov 21;129(11):2372-2379. Epub 2018 Sep 21.

Department of Neurophysiopathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy.

Objective: To investigate the changes in EEG connectivity in children with the typical presentation of benign epilepsy with centro-temporal spikes (BECTS).

Methods: We compared awake and spindle-sleep EEG recordings obtained by a standard electrode array in patients with lateralised (10 Right, 9 Left-BECTS) or bilateral spikes (10 MF-BECTS) and in 17 age-matched controls. We analysed EEG activity using partial directed coherence, an estimator of connectivity based on the multivariate autoregressive models and calculated in- and out-degrees, strength, clustering coefficient and betweenness centrality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457183122
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http://dx.doi.org/10.1016/j.clinph.2018.09.008DOI Listing
November 2018
1 Read

[Speech and language neurodevelopmental disorders in epilepsy: pathophysiologic mechanisms and therapeutic approaches].

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(8):118-125

Pirogov Russian National Research Medical University, Moscow, Russia.

Speech and language development may be impaired in all forms of epilepsy involving specialized functional areas in the dominant cerebral hemisphere and their connections. The concept of epilepsy-aphasia clinical spectrum was recently proposed, but the notion of aphasia is quite conditional here as many of these patients demonstrate disorders of speech and language development from their infancy. Those forms of epilepsy are considered as continuum from the most severe Landau-Kleffner syndrome (LKS) and epilepsy with continuous spike-and-wave during sleep (CSWS) (also indicating as electrical status epilepticus during sleep - ESES) to intermediate epilepsy-aphasia disorders (with incomplete correspondence to diagnostic criteria of LKS and epilepsy with CSWS). Read More

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http://www.mediasphera.ru/issues/zhurnal-nevrologii-i-psikhi
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http://dx.doi.org/10.17116/jnevro2018118081118DOI Listing
January 2018
12 Reads

Benign epilepsy with centrotemporal spikes - Current concepts of diagnosis and treatment.

Neurol Neurochir Pol 2018 Nov - Dec;52(6):677-689. Epub 2018 Sep 7.

Pediatric Neurology and Pediatrics Clinic, Medical University of Warsaw, Warsaw, Poland.

Benign epilepsy with centrotemporal spikes (BECTS) is the most common focal epilepsy of the childhood and also one of the best known. It has a proclivity to start at a particular age and remit spontaneously before adolescence. Majority of patients may avoid long-term treatment, because of the mild course and very good outcome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283843183024
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http://dx.doi.org/10.1016/j.pjnns.2018.08.010DOI Listing
September 2018
7 Reads

Factors associated with electroencephalographic and clinical remission of benign childhood epilepsy with centrotemporal spikes.

Brain Dev 2018 Sep 8. Epub 2018 Sep 8.

Department of Pediatrics, Kyung Hee University, College of Medicine, Republic of Korea; Department of Pediatrics, Inje University College of Medicine, Sanggye Paik Hospital, Seoul, Republic of Korea. Electronic address:

Purpose: Benign childhood epilepsy with centrotemporal spikes (BECTS) is strongly related to age, both to age at the time of seizure onset and to age at remission. However, the age of remission varies. The present study analyzed factors associated with remission of BECTS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604183037
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http://dx.doi.org/10.1016/j.braindev.2018.08.011DOI Listing
September 2018
1 Read

Effects of Antiepileptic Drugs on Language Abilities in Benign Epilepsy of Childhood with Centrotemporal Spikes.

J Clin Neurol 2018 Oct 6;14(4):523-529. Epub 2018 Sep 6.

Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.

Background And Purpose: This study is to assess the responsiveness of electroencephalography (EEG) abnormalities and their effects on language ability after initiating different types of antiepileptic therapy in children with newly diagnosed benign epilepsy of childhood with centrotemporal spikes (BECTS).

Methods: The records of patients newly diagnosed with BECTS (=120; 69 males) were reviewed retrospectively. The patients were randomly treated with lamotrigine, oxcarbazepine, or topiramate monotherapy, and underwent at least two EEG and standardized language tests. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3988/jcn.2018.14
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http://dx.doi.org/10.3988/jcn.2018.14.4.523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172516PMC
October 2018
2 Reads

Transient microstructural brain anomalies and epileptiform discharges in mice defective for epilepsy and language-related NMDA receptor subunit gene Grin2a.

Epilepsia 2018 Oct 26;59(10):1919-1930. Epub 2018 Aug 26.

INSERM, UMR1249, INMED, Aix-Marseille University, Marseille, France.

Objective: The epilepsy-aphasia spectrum (EAS) is a heterogeneous group of age-dependent childhood disorders characterized by sleep-activated discharges associated with infrequent seizures and language, cognitive, and behavioral deficits. Defects in the GRIN2A gene, encoding a subunit of glutamate-gated N-methyl-d-aspartate (NMDA) receptors, represent the most important cause of EAS identified so far. Neocortical or thalamic lesions were detected in a subset of severe EAS disorders, and more subtle anomalies were reported in patients with so-called "benign" phenotypes. Read More

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http://doi.wiley.com/10.1111/epi.14543
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http://dx.doi.org/10.1111/epi.14543DOI Listing
October 2018
8 Reads

Epilepsy Surgery in the First 3 Years of Life: Predictors of Seizure Freedom and Cognitive Development.

Neurosurgery 2018 Aug 21. Epub 2018 Aug 21.

Medical Faculty, University of Freiburg, Freiburg, Germany.

Background: Although the majority of children undergoing epilepsy surgery are younger than 3 yr at epilepsy manifestation, only few actually receive surgical treatment in early childhood. Past studies have, however, suggested that earlier intervention may correlate with superior developmental outcomes.

Objective: To identify predictors for long-term seizure freedom and cognitive development following epilepsy surgery in the first 3 yr of life and determine the appropriate timing for surgical treatment in this age group. Read More

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https://academic.oup.com/neurosurgery/advance-article/doi/10
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http://dx.doi.org/10.1093/neuros/nyy376DOI Listing
August 2018
6 Reads

Abnormal cortical activation during an auditory word comprehension task in benign childhood epilepsy with centrotemporal spikes: A magnetoencephalographic study.

Epilepsy Behav 2018 Aug 14. Epub 2018 Aug 14.

Division of Developmental Neuroscience, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan; Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Objective: Benign childhood epilepsy with centrotemporal spikes (BECTS), also known as rolandic epilepsy, has recently been reported to be associated with variable degrees of cognitive dysfunction. Many studies reported poor language ability in children with BECTS compared with healthy control children. To elucidate the harmful effects of BECTS on language cognition, we studied the magnetoencephalographic activity elicited by an auditory language comprehension task. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183029
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http://dx.doi.org/10.1016/j.yebeh.2018.05.035DOI Listing
August 2018
9 Reads

Frequency-specific alterations in the amplitude and synchronization of resting-state spontaneous low-frequency oscillations in benign childhood epilepsy with centrotemporal spikes.

Epilepsy Res 2018 Sep 19;145:178-184. Epub 2018 Jul 19.

Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, Sichuan Province, China. Electronic address:

Objectives: Spontaneous low-frequency oscillations in different frequency bands have diverse physiological meanings. The amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) in different frequency bands in Benign Childhood Epilepsy with Centrotemporal Spikes (BECTS) are unknown and worth exploring.

Method: Resting-state functional magnetic resonance imaging data were collected in 51 drug-naïve BECTS patients and 76 healthy controls. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.07.007DOI Listing
September 2018
1 Read

Febrile seizures: an overview.

Drugs Context 2018 16;7:212536. Epub 2018 Jul 16.

Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

Background: Febrile seizures are the most common neurologic disorder in childhood. Physicians should be familiar with the proper evaluation and management of this common condition.

Objective: To provide an update on the current understanding, evaluation, and management of febrile seizures. Read More

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http://dx.doi.org/10.7573/dic.212536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052913PMC
July 2018
11 Reads

Could Rolandic spikes be a prognostic factor of the neurocognitive outcome of children with BECTS?

Epilepsy Behav 2018 Sep 19;86:157-162. Epub 2018 Jul 19.

"La Sapienza" University, Department of Pediatrics, Child Neurology Division, Italy. Electronic address:

Introduction: Rolandic epilepsy, also known as benign childhood epilepsy with centrotemporal spikes (BECTS), is one of the most common epileptic syndromes in previously healthy children. Despite what was known about the benignity of this syndrome, there is always more evidence about the involvement of the cognitive functions with different deficits in several domains to be investigated.

Aim Of The Study: The aim of our study was to describe prognostic electroencephalogram (EEG) pattern of an adverse cognitive development to recognize patients at higher risk of lasting cognitive deficits that could need antiepileptic drugs (AEDs) or an improved neurocognitive therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183010
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http://dx.doi.org/10.1016/j.yebeh.2018.03.022DOI Listing
September 2018
4 Reads

Enhancement and bilateral synchronization of ripples in atypical benign epilepsy of childhood with centrotemporal spikes.

Clin Neurophysiol 2018 Sep 6;129(9):1920-1925. Epub 2018 Jul 6.

Division of Neurology, Saitama Children's Medical Center, 2-1Shin-toshin, Chuou-ku, Saitama-city, Saitama 330-8777, Japan.

Objective: To determine whether the characteristics of scalp-recorded high frequency oscillations, especially ripples, can predict the "atypical forms" of benign epilepsy of childhood with centrotemporal spikes (ABECTS), in BECTS.

Methods: Seven patients with ABECTS and eighteen patients with BECTS underwent electroencephalography (EEG) in the secondary bilateral synchrony (SBS) and non-SBS periods for ABECTS patients. SBS period is that when more than 50% of the interictal epileptiform discharges (IEDs) are bilaterally synchronized. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.06.023DOI Listing
September 2018
2 Reads

[Phenotype study of SCN2A gene related epilepsy].

Zhonghua Er Ke Za Zhi 2018 Jul;56(7):518-523

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To summarize the phenotype of epileptic children with SCN2A mutations. Epileptic patients who were treated in the Pediatric Department of Peking University First Hospital from September 2006 to October 2017 and detected with SCN2A mutations by targeted next-generation sequencing were enrolled. Clinical manifestations of all patients were analyzed retrospectively. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.07.009DOI Listing
July 2018
5 Reads

[Study of GRIN2A mutation in epilepsy-aphasia spectrum disorders].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Jun;35(3):314-318

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

Objective: To detect potential mutations of the glutamate receptor subunit (GRIN2A) gene and delineate the clinical-genetic characteristics of patients with epilepsy-aphasia spectrum (EAS) disorders.

Methods: One hundred twenty two patients with Landau-Kleffner syndrome (LKS), epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS), benign childhood epilepsy with centrotemporal spikes (BECT) and BECT variants were recruited. Potential mutations of the GRIN2A gene were screened with Sanger sequencing. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2018.03.002DOI Listing
June 2018
29 Reads

Consecutive occurrence of benign epilepsy with centro-temporal spike and childhood absence epilepsy: true coexistence or atypical evolution?

World J Pediatr 2018 08 22;14(4):410-411. Epub 2018 May 22.

Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea.

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http://dx.doi.org/10.1007/s12519-018-0148-4DOI Listing
August 2018
10 Reads

Myotonia permanens with Nav1.4-G1306E displays varied phenotypes during course of life.

Acta Myol 2017 Sep 1;36(3):125-134. Epub 2017 Sep 1.

Department of Neurosurgery, Ulm University, Ulm, Germany.

Introduction: Myotonia permanens due to Nav1.4-G1306E is a rare sodium channelopathy with potentially life-threatening respiratory complications. Our goal was to study phenotypic variability throughout life. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953224PMC
September 2017
3 Reads

Language skills in children with benign childhood epilepsy with centrotemporal spikes: A systematic review.

Epilepsy Behav 2018 Jul 3;84:15-21. Epub 2018 May 3.

Centro de Investigação Interdisciplinar em Saúde, Universidade Católica Portuguesa, Portugal.

Benign childhood epilepsy with centrotemporal spikes (BECTS) is the epileptic syndrome that most affects preschool and school-age children. Despite being usually considered a benign condition, several studies have shown that this epileptic syndrome is responsible for cognitive morbidities in children, namely at the level of attention and memory, as well as language. However, language disorders are still superficially addressed by the literature. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.04.002DOI Listing
July 2018
1 Read

Detection rate of causal variants in severe childhood epilepsy is highest in patients with seizure onset within the first four weeks of life.

Orphanet J Rare Dis 2018 May 2;13(1):71. Epub 2018 May 2.

Department of Paediatric Neurology, DNA Laboratory, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic.

Background: Epilepsy is a heterogeneous disease with a broad phenotypic spectrum and diverse genotypes. A significant proportion of epilepsies has a genetic aetiology. In our study, a custom designed gene panel with 112 genes known to be associated with epilepsies was used. Read More

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http://dx.doi.org/10.1186/s13023-018-0812-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932755PMC
May 2018
9 Reads

The relevance of attention deficit hyperactivity disorder in self-limited childhood epilepsy with centrotemporal spikes.

Epilepsy Behav 2018 05 9;82:164-169. Epub 2018 Apr 9.

Department of Psychiatry, Hospital das Clinicas, University of São Paulo-HCFMUSP, Sao Paulo, Brazil. Electronic address:

In this study, we aimed to evaluate the attentional and executive functions in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS) with and without attention-deficit hyperactivity disorder (ADHD) compared with controls and compared with patients with ADHD without epilepsy. We evaluated 12 patients with BCECTS and ADHD (66.7% boys; mean age of 9. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.03.017DOI Listing
May 2018
1 Read

The focal alteration and causal connectivity in children with new-onset benign epilepsy with centrotemporal spikes.

Sci Rep 2018 Apr 9;8(1):5689. Epub 2018 Apr 9.

Epilepsy Center, Department of Neurology, West China Hospital, Sichuan University, Chengdu, PR China.

The aim of the current study was to find the epileptic focus and examine its causal relationship to other brain regions in children with new-onset benign childhood epilepsy with centrotemporal spikes (BECTS). Resting-state functional magnetic resonance imaging (fMRI) was performed in 66 children with BECTS and 37 matched control children. We compared the amplitude of low frequency fluctuation (ALFF) signals between the two groups to find the potential epileptogenic zone (EZ), then used Granger causality analysis (GCA) to explore the causal effects of EZ on the whole brain. Read More

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http://dx.doi.org/10.1038/s41598-018-23336-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890242PMC
April 2018
2 Reads

Role of Language-Related Functional Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes.

J Clin Neurol 2018 Jan;14(1):48-57

Department of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul, Korea.

Background And Purpose: Benign childhood epilepsy with centrotemporal spikes (BECTS) does not always have a benign cognitive outcome. We investigated the relationship between cognitive performance and altered functional connectivity (FC) in the resting-state brain networks of BECTS patients.

Methods: We studied 42 subjects, comprising 19 BECTS patients and 23 healthy controls. Read More

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http://dx.doi.org/10.3988/jcn.2018.14.1.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765256PMC
January 2018
2 Reads

Language function in childhood idiopathic epilepsy syndromes.

Brain Lang 2018 Mar 30. Epub 2018 Mar 30.

Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States. Electronic address:

Purpose: To examine the impact of diverse syndromes of focal and generalized epilepsy on language function in children with new and recent onset epilepsy. Of special interest was the degree of shared language abnormality across epilepsy syndromes and the unique effects associated with specific epilepsy syndromes.

Methods: Participants were 136 youth with new or recent-onset (diagnosis within past 12 months) epilepsy and 107 healthy first-degree cousin controls. Read More

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http://dx.doi.org/10.1016/j.bandl.2017.12.005DOI Listing
March 2018
3 Reads

Juvenile myoclonic epilepsy refractory to treatment in a tertiary referral center.

Epilepsy Behav 2018 05 27;82:81-86. Epub 2018 Mar 27.

NIHR University College London Hospitals Biomedical Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK; Chalfont Centre for Epilepsy, Chalfont St Peter, Bucks SL9 8ES, UK; Stichting Epilepsie Instellingen Nederland (SEIN), Achterweg 5, 2103SW Heemstede, Netherlands.

Introduction: Juvenile myoclonic epilepsy (JME) is an epileptic syndrome often regarded as one in which seizures are relatively easy to control. Individuals with JME, however, often require lifelong therapy to remain seizure-free, and a few have refractory epilepsy. We ascertained a population with JME and characterized a subgroup with refractory epilepsy. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.03.002DOI Listing
May 2018
1 Read
2.260 Impact Factor

Tantrums, Emotion Reactions and Their EEG Correlates in Childhood Benign Rolandic Epilepsy vs. Complex Partial Seizures: Exploratory Observations.

Front Behav Neurosci 2018 9;12:40. Epub 2018 Mar 9.

Department of Neurology, Medical School, University of Minnesota, Minneapolis, MN, United States.

We explored associations between EEG pathophysiology and emotional/behavioral (E/B) problems of children with two types of epilepsy using standard parent questionnaires and two new indicators: tantrums recorded by parents at home and brief, emotion-eliciting situations in the laboratory. Children with Benign Rolandic epilepsy (BRE, = 6) reportedly had shorter, more angry tantrums from which they recovered quickly. Children with Complex Partial Seizures (CPS, = 13) had longer, sadder tantrums often followed by bad moods. Read More

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http://dx.doi.org/10.3389/fnbeh.2018.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854949PMC
March 2018
5 Reads

Panayiotopoulos syndrome and benign partial epilepsy with centro-temporal spikes: A comparative incidence study.

Seizure 2018 Apr 5;57:66-69. Epub 2018 Mar 5.

Alder Hey Children's Hospital, Liverpool, United Kingdom.

Purpose: To compare the de novo incidence of Panayiotopoulos syndrome (PS, early-onset childhood occipital epilepsy) and a common epilepsy syndrome, benign epilepsy with centro-temporal spikes (BECTS), in children and young people.

Methods: The incidence of PS and BECTS was recorded over 16 months in a population of children and young people (aged <16 years) living within a specific geographic area and epilepsy network within the North West of England and North Wales and the catchment area of the tertiary paediatric epilepsy centre. Monthly data collection proformas were circulated to the paediatricians and paediatric neurologists responsible for the evaluation of epilepsy in children within this area. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311173079
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http://dx.doi.org/10.1016/j.seizure.2018.03.002DOI Listing
April 2018
5 Reads

Effects of Levetiracetam and Sulthiame on EEG in benign epilepsy with centrotemporal spikes: A randomized controlled trial.

Seizure 2018 Mar 3;56:115-120. Epub 2018 Feb 3.

Clemens Hospital, Münster, Germany.

Purpose: BECTS (benign childhood epilepsy with centrotemporal spikes) is associated with characteristic EEG findings. This study examines the influence of anti-convulsive treatment on the EEG.

Methods: In a randomized controlled trial including 43 children with BECTS, EEGs were performed prior to treatment with either Sulthiame or Levetiracetam as well as three times under treatment. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.01.015DOI Listing
March 2018
26 Reads

Structural Covariance Network of Cortical Gyrification in Benign Childhood Epilepsy with Centrotemporal Spikes.

Front Neurol 2018 5;9:10. Epub 2018 Feb 5.

Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Benign childhood epilepsy with centrotemporal spikes (BECTS) is associated with cognitive and language problems. According to recent studies, disruptions in brain structure and function in children with BECTS are beyond a Rolandic focus, suggesting atypical cortical development. However, previous studies utilizing surface-based metrics (e. Read More

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http://dx.doi.org/10.3389/fneur.2018.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807981PMC
February 2018
4 Reads

Syndromic sebaceous nevus: current findings.

Int J Dermatol 2018 May 16;57(5):599-604. Epub 2018 Feb 16.

Service of Pediatric Orthopedic Plastic Surgery, Hôpital Lapeyronie, Montpellier, France.

Background: Sebaceous nevus is a congenital malformation of the skin that usually occurs on the scalp or face. Syndromic forms do rarely exist with associated cerebral and ocular malformations. The skin lesions are pale at birth and become irregular by puberty. Read More

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http://dx.doi.org/10.1111/ijd.13942DOI Listing
May 2018
6 Reads

Epilepsy Syndromes in Childhood.

Authors:
Phillip L Pearl

Continuum (Minneap Minn) 2018 02;24(1, Child Neurology):186-209

Purpose Of Review: Epilepsy syndromes are an important clinical construct in pediatric epilepsy, as they encompass recognizable patterns seen in patients with epilepsies, whether of the more benign variety or associated with encephalopathy.

Recent Findings: Syndromes may be organized by age of onset: neonatal, infantile, childhood, or adolescent. The assignment of a syndrome has specific implications for diagnosis, management, and prognostication. Read More

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http://dx.doi.org/10.1212/CON.0000000000000568DOI Listing
February 2018
4 Reads

Brain responses to auditory oddball task in children with benign childhood epilepsy with centrotemporal spikes: Quantitative analysis and correlation with neuropsychological assessment scores.

Epilepsy Behav 2018 03 2;80:272-279. Epub 2018 Feb 2.

Department of Clinical Neurophysiology, Cairo University, Egypt.

Objective: Variable degrees of cognitive dysfunction have been reported in children with benign childhood epilepsy with centrotemporal spikes (BCECTS). Our aim was to perform quantitative analyses of the brain responses to cognitive tasks using event-related desynchronization (ERD) and event-related synchronization (ERS) and correlating the results with the scores of neuropsychological tests in patients with BCECTS.

Methods: This case control study included 30 patients with BCECTS and 20 controls. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.01.017DOI Listing
March 2018
4 Reads

[Epileptic syndromes in childhood associated with secondary generalized tonic-clonic seizures].

Zh Nevrol Psikhiatr Im S S Korsakova 2017 ;117(11. Vyp. 2):23-32

Research Center of Child Psychoneurology, Moscow, Russia.

Aim: To study a group of patients with secondary generalized tonic-clonic seizures (SGTCS) in view of nosology, medical history, clinical, electroencephalographic and neuroimaging features.

Material And Methods: The study included 471 patients, 244 (51.8%) men and 227 (48. Read More

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http://dx.doi.org/10.17116/jnevro201711711223-32DOI Listing
January 2017
2 Reads

Prevalence of idiopathic epilepsy among school children in Gharbia Governorate, Egypt.

Brain Dev 2018 Apr 30;40(4):278-286. Epub 2017 Dec 30.

Pediatric Cardiology Unit, Department of Pediatrics, Tanta University Hospital, Faculty of Medicine, Tanta, Egypt.

Background: Epilepsy is one of the most common neurological disorders among children. Data about its prevalence in Egypt is limited. Our aim was to study the prevalence of idiopathic epilepsy among school children in Gharbia governorate, Egypt. Read More

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http://dx.doi.org/10.1016/j.braindev.2017.12.009DOI Listing
April 2018
4 Reads

Identifying neural drivers of benign childhood epilepsy with centrotemporal spikes.

Neuroimage Clin 2018 5;17:739-750. Epub 2017 Dec 5.

INSERM UMR 1105, Research Group on Multimodal Analysis of Brain Function, University of Picardy Jules Verne, 80036 Amiens Cedex, France.

Epilepsy is a neurological disorder characterized by abnormal electrical discharges in a group of brain cells. Benign childhood epilepsy, which affect children under the age of 12 years, has been reported to contribute to the cognitive impairment of these children, even in the absence of structural abnormalities. Functional connectivity models have been applied to provide a deeper understanding of the processes that control and regulate interictal activity of benign childhood epilepsy. Read More

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http://dx.doi.org/10.1016/j.nicl.2017.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730126PMC
December 2017
9 Reads

The influence of EEG-detected nocturnal centrotemporal discharges on the expression of core symptoms of ADHD in children with benign childhood epilepsy with centrotemporal spikes (BCECTS): A prospective study in a tertiary referral center.

Epilepsy Behav 2018 02 15;79:75-81. Epub 2017 Dec 15.

Brno Epilepsy Center, Department of Pediatric Neurology, University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address:

Benign childhood epilepsy with centrotemporal spikes (BCECTS) is the most frequent benign focal epilepsy in childhood. Although it is described as a benign epilepsy syndrome, many studies have revealed that a significant number of patients have some degree of neuropsychological impairment. Thirty-two patients with BCECTS aged 6-11years were included in the study. Read More

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http://dx.doi.org/10.1016/j.yebeh.2017.11.007DOI Listing
February 2018
16 Reads

Prognostic factors for epilepsy following first febrile seizure in Saudi children.

Ann Saudi Med 2017 Nov-Dec;37(6):449-454

Dr. Abdullah Ibrahim Almojali, College of Medicine, King Saud bin Abdulaziz University for Health Sciences,, PO Box 22490, Riyadh 11426, Saudi Arabia, T: +966-11-4299999, http://orcid.org/0000-0003-4208-4196.

Background: Febrile seizure is the most common convulsive event during childhood, but it is generally considered benign.

Objectives: To estimate the rate of epilepsy after first presentation of febrile seizure and to describe factors that can predispose children to have subsequent epilepsy after their first febrile seizure.

Design: Retrospective chart review. Read More

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http://dx.doi.org/10.5144/0256-4947.2017.449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074123PMC
July 2018
15 Reads
0.705 Impact Factor

[The course and development of epilepsy in patients with typical variant of Rett syndrome and mutations].

Zh Nevrol Psikhiatr Im S S Korsakova 2017 ;117(9. Vyp. 2):80-87

Pirogov Russian National Research Medical University, Moscow, Russia.

Aim: To study the anamnesis, clinical state, electro-encephalographic and brain MRI characteristics in patients with Rett syndrome (МЕСР2) and epilepsy.

Material And Methods: Eleven female patients, aged from 3 to 23 years, with Rett syndrome and MeCP2 mutations were studied. The study continued for 10 years (2006-2015). Read More

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http://dx.doi.org/10.17116/jnevro20171179280-87DOI Listing
January 2017
18 Reads

[Treatment of rolandic epilepsy].

Ugeskr Laeger 2017 Nov;179(48)

Recent literature indicates, that rolandic epilepsy/epilepsy of childhood with centrotemporal spikes may not be as benign as previously assumed. This study investigates the existing evidence, which describes the treatment effects on seizure frequency as well as improvement of cognition in children with rolandic epilepsy. We conclude, that treatment with anti-epileptic drugs could be justified, if treatment reduces seizures, prevents the evolution to atypical forms, or diminishes the negative cognitive consequences associated with the disease. Read More

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November 2017
8 Reads

Benign Rolandic epilepsy presenting like paradoxical vocal fold motion.

Int J Pediatr Otorhinolaryngol 2017 Nov 22;102:154-156. Epub 2017 Sep 22.

Washington University School of Medicine, Department of Otolaryngology, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA. Electronic address:

Paradoxical vocal fold motion (PVFM) is characterized by vocal fold adduction during respiration. Benign Rolandic epilepsy (BRE) is the most common childhood epilepsy and can cause oropharyngolaryngeal or facial manifestations. A 9-year-old male presented with intermittent apnea lasting 30-60 seconds and presumed PVFM. Read More

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http://dx.doi.org/10.1016/j.ijporl.2017.09.021DOI Listing
November 2017
12 Reads

Frontal Lobe Epilepsy Surgery in Childhood and Adolescence: Predictors of Long-Term Seizure Freedom, Overall Cognitive and Adaptive Functioning.

Neurosurgery 2018 Jul;83(1):93-103

Epilepsy Centre Kork, Kehl-Kork, Germany.

Background: Although frontal lobe resections account for one-third of intralobar resections in pediatric epilepsy surgery, there is a dearth of information regarding long-term seizure freedom, overall cognitive and adaptive functioning.

Objective: To identify outcome predictors and define the appropriate timing for surgery.

Methods: We retrospectively analyzed the data of 75 consecutive patients aged 10. Read More

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http://dx.doi.org/10.1093/neuros/nyx340DOI Listing
July 2018
18 Reads

Paroxysmal Tonic Upgaze in Children: Three Case Reports and a Review of the Literature.

Authors:
Ayse Kartal

Pediatr Emerg Care 2017 Oct 31. Epub 2017 Oct 31.

From the Division of Child Neurology, Selçuk University Faculty of Medicine, Alaeddin Kampusu, Selçuklu/Konya, Turkey.

Background: In clinical practice, nonepileptic paroxysmal events during infancy and childhood are common reasons for parents and caregivers to seek for medical advice. These events are mostly unrecognized and considered as an epileptic seizure because of the clinical features resembling an epileptic seizure. Paroxysmal tonic upgaze, which consists of recurrent episodes of sustained upward deviation of the eyes and incomplete downward saccades, and normal horizontal eye movements without impairment of consciousness, is a diagnostic challenge for the pediatrician and pediatric neurologist. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001327DOI Listing
October 2017
9 Reads

Occipital dysembryoplastic neuroepithelial tumor presenting as adult-onset temporal epilepsy.

Epilepsy Behav Case Rep 2017 12;8:92-95. Epub 2017 Sep 12.

Department of Neurology, Temple University Hospital, Philadelphia, PA 19140, USA.

Dysembryoplastic neuroepithelial tumor (DNET) is a benign brain tumor which commonly presents as childhood-onset temporal lobe epilepsy (TLE). We present a case of histologically proven DNET with a clinical presentation and scalp EEG suggestive of adult-onset TLE. MRI showed an occipital lesion. Read More

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http://dx.doi.org/10.1016/j.ebcr.2017.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645159PMC
September 2017
10 Reads

Sub-cortical brain morphometry and its relationship with cognition in rolandic epilepsy.

Epilepsy Res 2017 12 7;138:39-45. Epub 2017 Oct 7.

CHU Sainte-Justine, Montreal, Quebec, Canada; University of Montreal, Department of Psychology, Montreal, Quebec, Canada.

Purpose: Rolandic epilepsy (RE), also called benign epilepsy with centrotemporal spikes (BECTS) is the most common childhood epilepsy syndrome. RE is associated with cognitive difficulties, which can affect children's quality of life. The underlying causes of these cognitive impairments are unclear. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2017.09.007DOI Listing
December 2017
11 Reads

[Clinicopathologic features of infant dysembryoplastic neuroepithelial tumor: a case report and literature review].

Beijing Da Xue Xue Bao Yi Xue Ban 2017 Oct;49(5):904-909

Department of Pathology, Peking University First Hospital, Beijing 100034, China.

Dysembryoplastic neuroepithelial tumor (DNT) has traditionally been viewed as rare benign tumors that present with seizure widely considered curable with surgery alone. Most DNTs occur in childhood and young adults. However, rare reported cases occur in infants. Read More

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October 2017
19 Reads

[Evaluating a child after a febrile seizure: Insights on three important issues].

Arch Pediatr 2017 Nov 29;24(11):1137-1146. Epub 2017 Sep 29.

Service de neurologie pédiatrique, CHU de la Timone, AP-HM, 264, rue Saint-Pierre, 13005 Marseille, France.

Febrile seizures (FS) are the most common seizures seen in the paediatric population in the out-of-hospital and emergency department settings, and they account for the majority of seizures seen in children younger than 5 years old. An FS is a seizure accompanied by fever, without central nervous system infection, occurring in children between 6 months and 5 years old. Five criteria have been used and taught to classify any FS as simple or complex FS. Read More

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http://dx.doi.org/10.1016/j.arcped.2017.08.018DOI Listing
November 2017
8 Reads