1,123 results match your criteria Benign Childhood Epilepsy


Fever-Associated Seizures or Epilepsy: An Overview of Old and Recent Literature Acquisitions.

Front Pediatr 2022 21;10:858945. Epub 2022 Apr 21.

Unit of Rare Diseases of the Nervous System in Childhood, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, AOU "Policlinico", PO "G. Rodolico", Catania, Italy.

In addition to central nervous system infections, seizures and fever may occur together in several neurological disorders. Formerly, based on the clinical features and prognostic evolution, the co-association of seizure and fever included classical febrile seizures (FS) divided into simple, complex, and prolonged FS (also called febrile status epilepticus). Later, this group of disorders has been progressively indicated, with a more inclusive term, as "fever-associated seizures or epilepsy" (FASE) that encompasses: (a) FS divided into simple, complex, and prolonged FS; (b) FS plus; (c) severe myoclonic epilepsy in infancy (Dravet syndrome); (d) genetic epilepsy with FS plus; and (e) febrile infection-related epilepsy syndrome (FIRES). Read More

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International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions.

Epilepsia 2022 May 3. Epub 2022 May 3.

Robert Debré Hospital, Public Hospital Network of Paris, NeuroDiderot, National Institute of Health and Medical Research, Department Medico-Universitaire Innovation Robert-Debré, Pediatric Neurology, University of Paris, Paris, France.

The 2017 International League Against Epilepsy classification has defined a three-tier system with epilepsy syndrome identification at the third level. Although a syndrome cannot be determined in all children with epilepsy, identification of a specific syndrome provides guidance on management and prognosis. In this paper, we describe the childhood onset epilepsy syndromes, most of which have both mandatory seizure type(s) and interictal electroencephalographic (EEG) features. Read More

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Phenotypic Spectrum in a Family Sharing a Heterozygous Variant.

J Child Neurol 2022 Apr 6:8830738221089741. Epub 2022 Apr 6.

Department of Pediatrics, 12306The Ohio State University, Columbus, OH, USA.

Background And Purpose: Mutations in have classically been associated with benign familial neonatal and infantile seizures and more recently identified in patients with neurodevelopmental disorders and abnormal electroencephalogram (EEG) findings. We present 4 affected patients from a family with a pathogenic mutation in with a unique constellation of clinical findings.

Methods: A family of 3 affected siblings and mother sharing a pathogenic variant are described, including clinical history, genetic results, and EEG and magnetic resonance imaging (MRI) findings. Read More

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Electrical status epilepticus during sleep (ESES) in benign childhood epilepsy with Centrotemporal spikes (BCECTS): insights into predictive factors, and clinical and EEG outcomes.

Eur Rev Med Pharmacol Sci 2022 03;26(6):1885-1896

Department of Pediatric Neurology, Adana City Training and Research Hospital, Adana, Turkey.

Objective: Benign childhood epilepsy with centro-temporal spikes (BCECTS), otherwise known as benign rolandic epilepsy, is the most common focal epilepsy in childhood. This study aimed to evaluate the development and resolution of ESES in children with BCECTS and evaluate the clinical and electroencephalography (EEG) parameters associated with prognosis.

Patients And Methods: Resolution of ESES was defined as the reduction of the spike-wave index (SWI) to <50%. Read More

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Anti-Seizure Medication Treatment of Benign Childhood Epilepsy With Centrotemporal Spikes: A Systematic Review and Meta-analysis.

Front Pharmacol 2022 10;13:821639. Epub 2022 Mar 10.

Department of Neurology, Maoming People's Hospital, Maoming, China.

This study aimed to evaluate the efficacy and tolerability of Anti-Seizure medication (ASM) treatment in patients with BECTS. We searched PubMed, Cochrane Library, Embase, MEDLINE, Web of Science, China National Knowledge Infrastructure (CNKI), WANFANG DATA, and China Science and Technology Journal Database (VIP) between 1 Jan 1990, and 1 Sep 2021, for randomized controlled studies. Data on seizure freedom rate, rate of treatment withdrawal due to serious adverse events, rate of any adverse events and dropout, 50% remission rate, the proportion of patients whose EEG to be normalized, and improvement in cognitive function were extracted by two authors independently. Read More

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Deep feature fusion based childhood epilepsy syndrome classification from electroencephalogram.

Neural Netw 2022 Jun 15;150:313-325. Epub 2022 Mar 15.

Department of Neurology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310003, China.

Accurate classification of the children's epilepsy syndrome is vital to the diagnosis and treatment of epilepsy. But existing literature mainly focuses on seizure detection and few attention has been paid to the children's epilepsy syndrome classification. In this paper, we present a study on the classification of two most common epilepsy syndromes: the benign childhood epilepsy with centro-temporal spikes (BECT) and the infantile spasms (also known as the WEST syndrome), recorded from the Children's Hospital, Zhejiang University School of Medicine (CHZU). Read More

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Different Prognostic Patterns in Epilepsies and Considerations About the Denotations of Atypical Patterns.

Noro Psikiyatr Ars 2022 31;59(1):68-76. Epub 2022 Jan 31.

Istanbul University, Istanbul Faculty of Medicine, Department of Neurology and Clinical Neurophysiology, Istanbul, Turkey.

Epilepsy is a dynamic and heterogeneous neurological disease, and in long-term studies on prognosis, classically 5 basic patterns (early remission, late remission, relapsing-remitting, worsening, and non-remitting) have been identified. The most frequent pattern was relapsing-remitting course, and factors such as the presence of genetic etiology, rare seizures at the beginning of epilepsy and the absence of psychiatric comorbid diseases were found to be related with this pattern as well as reaching 5 years of remission in the follow-ups. Anti-seizure drug resistance (ASD-R) and factors affecting the presence of this resistance (such as symptomatic etiology, abnormal electroencephalographic findings, having multiple seizure types together, status epilepticus and febrile seizure history) decrease the chance of remission, while idiopathic/genetic etiology, generalized epilepsy, and absence of comorbid diseases seem to be associated with achieving long-term remission. Read More

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January 2022

One Child's Struggle in School: A Case Report of a Diagnosis of Seizures.

Authors:
Nancy McClurg

J Pediatr Health Care 2022 May-Jun;36(3):277-279. Epub 2022 Mar 6.

Nancy McClurg, Instructor, Angelina College, Lufkin, TX. Electronic address:

Some children diagnosed with epilepsy also have attention deficit hyperactivity disorder. Parents, teachers, and health care professionals may be the first to notice and recognize symptoms of a seizure in a child. In this case report, a patient's journey to a diagnosis of benign rolandic epilepsy will be reviewed. Read More

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De novo GRIN2A variants associated with epilepsy and autism and literature review.

Epilepsy Behav 2022 04 23;129:108604. Epub 2022 Feb 23.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialities "G. D'Alessandro", University of Palermo, Palermo, Italy. Electronic address:

N-methyl-D-aspartate receptors (NMDAR) are di- or tri-heterotetrameric ligand-gated ion channels composed of two obligate glycine-binding GluN1 subunits and two glutamate-binding GluN2 or GluN3 subunits, encoded by GRIN1, GRIN2A-D, and GRIN3A-B receptor genes respectively. Each NMDA receptor subtype has different temporal and spatial expression patterns in the brain and varies in the cell types and subcellular localization resulting in different functions. They play a crucial role in mediating the excitatory neurotransmission, but are also involved in neuronal development and synaptic plasticity, essential for learning, memory, and high cognitive functions. Read More

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Differentiating early clinical features of Panayiotopoulos syndrome from acute encephalopathy.

Brain Dev 2022 Jun 10;44(6):386-390. Epub 2022 Feb 10.

Center for Postgraduate Education and Training, National Center for Child Health and Development, Tokyo, Japan. Electronic address:

Background: Panayiotopoulos syndrome (PS) is a common benign epilepsy in childhood, characterized by predominantly autonomic symptoms such as emesis, pallor, and seizures, which are often prolonged. In an emergency room (ER), particularly when unconsciousness is prolonged, differentiating PS from acute encephalopathy is challenging. In this study, we aimed to elucidate the differences in clinical features of patients with PS and acute encephalopathy who visited our ER. Read More

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Neuropsychological and behavioral profiles of self-limited epileptic syndromes of childhood: a cross-syndrome comparison.

Child Neuropsychol 2022 Jan 27:1-25. Epub 2022 Jan 27.

Epilepsy and Clinical Neurophysiology Unit, Irccs "E. Medea," Conegliano, Treviso, Italy.

Childhood epilepsy with centro-temporal spikes (CECTS), Childhood absence epilepsy (CAE) and Panayiotopoulos syndrome (PS) are some of the most common pediatric epileptic syndromes. Despite the relatively benign (self-limited) course of epilepsy, current evidence suggests that these conditions are associated with an increased risk of neuropsychological and behavioral comorbidities. This study provides a cross-epileptic syndromes' comparison reporting on the cognitive and behavioral profile of a cohort of 32 children with CECTS (n = 14), CAE (n = 10) and PS (n = 8), aged 6 to 15 years old. Read More

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January 2022

EMD-WOG-2DCNN based EEG signal processing for Rolandic seizure classification.

Comput Methods Biomech Biomed Engin 2022 Jan 19:1-11. Epub 2022 Jan 19.

Department of Neurology, Children's Hospital of Fudan University, Shanghai, China.

Approximately 65 million people have epilepsy around the world. Recognition of epilepsy types is the basis to determine the treatment method and predict the prognosis in epilepsy patients. Childhood benign epilepsy with centrotemporal spikes (BECTS) or benign Rolandic epilepsy is the most common focal epilepsy in children, accounting for 15-20% of childhood epilepsies. Read More

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January 2022

Therapeutic Options for Childhood Absence Epilepsy.

Pediatr Rep 2021 Dec 16;13(4):658-667. Epub 2021 Dec 16.

Pediatric Unit, Department of Medicine and Surgery, University of Perugia, 06156 Perugia, Italy.

Childhood absence epilepsy (CAE) is a common pediatric generalized epileptic syndrome. Although it is traditionally considered as a benign self-limited condition, the apparent benign nature of this syndrome has been revaluated in recent years. This is mainly due to the increasing evidence that children with CAE can present invalidating neuropsychological comorbidities that will affect them up to adulthood. Read More

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December 2021

Auditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes.

Cell Rep Med 2021 11 26;2(11):100432. Epub 2021 Oct 26.

Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, 72076 Tübingen, Germany.

Benign epilepsy with centrotemporal spikes (BECTS) is a common form of childhood epilepsy linked to diverse cognitive abnormalities. The electroencephalogram of patients shows focal interictal epileptic spikes, particularly during non-rapid eye movement (NonREM) sleep. Spike formation involves thalamocortical networks, which also contribute to the generation of sleep slow oscillations (SOs) and spindles. Read More

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November 2021

Oral dyspraxia in self-limited epilepsy with centrotemporal spikes: a comparative study with a control group.

Arq Neuropsiquiatr 2021 12;79(12):1076-1083

Universidade de São Paulo, Faculdade de Medicina, Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional, São Paulo SP, Brazil.

Background: self-limited epilepsy with centrotemporal spikes, previously considered benign focal childhood epilepsy with centrotemporal spikes show clinical signs of involvement of Rolandic areas, mainly lower area, which may affect the planning and execution of motor sequences.

Objective: This study aimed to evaluated oral praxis in children with self-limited epilepsy with centrotemporal spikes and compare to the age-matched control group.

Methods: This was a descriptive study with 74 children with self-limited epilepsy with centrotemporal spikes, with the classical forms according to International League Against Epilepsy, and between 4 and 15 years of age, selected from the child neurology outpatient clinic of the Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, and 239 age-matched and educational level-matched (convenience sampling) control children. Read More

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December 2021

6-year course of sleep homeostasis in a case with epilepsy-aphasia spectrum disorder.

Epilepsy Behav Rep 2021 30;16:100488. Epub 2021 Sep 30.

Department of Pediatric Neurology and Developmental Medicine, University of Basel Children's Hospital, Basel, Switzerland.

The epilepsy-aphasia spectrum consists of epilepsies with a strong activation of epileptic discharges during non-rapid-eye-movement (NREM) sleep, variable seizure burden and language problems. The homeostatic decrease of slow waves (SW) during NREM sleep (i.e. Read More

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September 2021

Involvement of brain structures in childhood epilepsy with centrotemporal spikes.

Pediatr Int 2022 Jan;64(1):e15001

Brain & Mind Research Center, Nagoya University, Nagoya, Japan.

Background: We aimed to investigate electroencephalography (EEG)-functional magnetic resonance imaging (fMRI) findings to elucidate the interictal epileptiform discharge (IED)-related functional alterations in deep brain structures and the neocortex in childhood epilepsy with centrotemporal spikes (CECTS).

Methods: Ten children with CECTS (median age 8.2 years), referred to our hospital within a year of onset, were eligible for inclusion. Read More

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January 2022

Sulthiame monotherapy for epilepsy.

Cochrane Database Syst Rev 2021 09 23;9:CD010062. Epub 2021 Sep 23.

Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

Background: This is an updated version of the original Cochrane Review published in 2014. Epilepsy is a common neurological condition characterised by recurrent seizures. Pharmacological treatment remains the first choice to control epilepsy. Read More

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September 2021

Clinical and histopathological profile of dysembryoplastic neuroepithelial tumor: An experience from a tertiary care center.

J Cancer Res Ther 2021 Jul-Sep;17(4):912-916

Department of Neurosurgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Introduction: Dysembryoplastic neuroepithelial tumor (DNT) is a rare benign brain tumor predominantly involving children and young adults. Histologically, it corresponds to WHO Grade I tumors; however, it may masquerade aggressive neural tumors such as oligodendroglioma, oligoastrocytoma, pilocytic astrocytoma, and ganglioglioma. The literature on clinical, radiological, and pathological spectrum of DNT is described mostly in the form of case reports, with only a few case series reported till date. Read More

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January 2022

Cognitive impairment in children with benign childhood epilepsy with centrotemporal spikes and attention deficit hyperactivity disorder: a prospective study.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Aug;23(8):791-796

Department of Pediatrics, Cangzhou People's Hospital, Cangzhou, Hebei 061000, China.

Objectives: To study the difference in cognitive impairment between the children with benign childhood epilepsy with centrotemporal spikes (BECT) and attention deficit hyperactivity disorder (ADHD) and those with BECT or ADHD alone.

Methods: A prospective study was performed on 80 children with BECT and ADHD, 91 children with BECT, and 70 children with ADHD , who were diagnosed with the diseases for the first time. Seventy children of the same age who underwent physical examination were enrolled as the healthy control group. Read More

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Atypical idiopathic intracranial hypertension presenting as cyclic vomiting syndrome: a case report.

J Med Case Rep 2021 Aug 31;15(1):440. Epub 2021 Aug 31.

Department of Neurology, Children's Memorial Hermann Hospital, 6410 Fannin St., Ste 1014, Houston, TX, 77030, USA.

Background: Idiopathic intracranial hypertension is a disorder of increased intracranial pressure in the absence of cerebrospinal outflow obstruction, mass lesion, or other underlying cause. It is a rare phenomenon in prepubertal children and is most typically found in women of childbearing age. The classic presentation consists of headaches, nausea, vomiting, and visual changes; however, children present more atypically. Read More

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Alterations in white matter integrity and asymmetry in patients with benign childhood epilepsy with centrotemporal spikes and childhood absence epilepsy: An automated fiber quantification tractography study.

Epilepsy Behav 2021 10 17;123:108235. Epub 2021 Aug 17.

Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, Jiangsu, People's Republic of China. Electronic address:

Purpose: To investigate whether patients with benign childhood epilepsy with centrotemporal spikes (BECTS) and childhood absence epilepsy (CAE) show distinct patterns of white matter (WM) alterations and structural asymmetry compared with healthy controls and the relationship between WM alterations and epilepsy-related clinical variables.

Methods: We used automated fiber quantification to create tract profiles of fractional anisotropy (FA) and mean diffusivity (MD) in twenty-six patients with BECTS, twenty-nine patients with CAE, and twenty-four healthy controls. Group differences in FA and MD were quantified at 100 equidistant nodes along the fiber tract and these alterations and epilepsy-related clinical variables were correlated. Read More

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October 2021

[Personalised epilepsy treatment].

Authors:
Anna Altmann

Ideggyogy Sz 2021 Jul;74(7-08):227-233

Észak-közép-budai Centrum, Új Szent János Kórház és Szakrendelô, Epilepszia-neurológiai Szakambulancia.

Epilepsy is one of the most common chronic neurological disease in childhood. Patients with epilepsy - even with so-called benign epilepsy - need medication for years. During this time, children go through a very big change, not only gaining weight and height, but also changing hormonal and metabolic processes. Read More

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Brain network excitatory/inhibitory imbalance is a biomarker for drug-naive Rolandic epilepsy: A radiomics strategy.

Epilepsia 2021 10 3;62(10):2426-2438. Epub 2021 Aug 3.

Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Taipa, Macau, China.

Objective: Seizure occurs when the balance between excitatory and inhibitory (E/I) inputs to neurons is perturbed, resulting in abnormal electrical activity. This study investigated whether an existing E/I imbalance in neural networks is a useful diagnostic biomarker for Rolandic epilepsy by a resting-state dynamic causal modeling-based support vector machine (rs-DCM-SVM) algorithm.

Methods: This multicenter study enrolled a discovery cohort (76 children with Rolandic epilepsy and 76 normal controls [NCs]) and a replication cohort (59 children with Rolandic epilepsy and 60 NCs). Read More

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October 2021

Ictal Hypersalivation and Salivary Gland Enlargement in a Patient With Acquired Frontal Lobe Epilepsy.

Cureus 2021 May 29;13(5):e15319. Epub 2021 May 29.

Pediatric Neurology, Louisiana State University Health Sciences Center, New Orleans, USA.

Hypersalivation is a well-known ictal semiology of benign Rolandic epilepsy and other childhood epilepsy syndromes. There are also occasional reports of adults with temporal, parietal, or frontal lobe epilepsy in which hypersalivation is a prominent seizure manifestation. Notably lacking are reports linking salivary gland enlargement to ictal hypersalivation. Read More

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Computational Evidence for a Competitive Thalamocortical Model of Spikes and Spindle Activity in Rolandic Epilepsy.

Front Comput Neurosci 2021 18;15:680549. Epub 2021 Jun 18.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Rolandic epilepsy (RE) is the most common idiopathic focal childhood epilepsy syndrome, characterized by sleep-activated epileptiform spikes and seizures and cognitive deficits in school age children. Recent evidence suggests that this disease may be caused by disruptions to the Rolandic thalamocortical circuit, resulting in both an abundance of epileptiform spikes and a paucity of sleep spindles in the Rolandic cortex during non-rapid eye movement sleep (NREM); electrographic features linked to seizures and cognitive symptoms, respectively. The neuronal mechanisms that support the competitive shared thalamocortical circuitry between pathological epileptiform spikes and physiological sleep spindles are not well-understood. Read More

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How often do neurological disorders lead to dizziness in childhood?

Turk Arch Pediatr 2021 6;56(3):249-253. Epub 2021 Jan 6.

Depatment of Pediatric Neurology, Ordu University Faculty of Medicine, Ordu, Turkey.

Objective: The aim of the study was to determine the features and differential diagnosis of childhood dizziness and find out the prevalence of neurological diseases in children who were referred to the pediatric neurology outpatient clinic. A secondary aim was to evaluate the outcome of dizziness after 12 months.

Material And Methods: The records of children with a complaint of dizziness that were referred to the pediatric neurology outpatient clinic were retrospectively reviewed, and detailed medical and family history, clinical characteristics, laboratory investigations including vitamin B12 levels, and neuroimaging tests were analyzed. Read More

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January 2021

Age-dependent neurological phenotypes in a mouse model of PRRT2-related diseases.

Neurogenetics 2021 07 8;22(3):171-185. Epub 2021 Jun 8.

Department of Neurology, University of California San Francisco, San Francisco, CA, 94143, USA.

Paroxysmal kinesigenic dyskinesia is an episodic movement disorder caused by dominant mutations in the proline-rich transmembrane protein PRRT2, with onset in childhood and typically with improvement or resolution by middle age. Mutations in the same gene may also cause benign infantile seizures, which begin in the first year of life and typically remit by the age of 2 years. Many details of PRRT2 function at the synapse, and the effects of mutations on neuronal excitability in the pathophysiology of epilepsy and dyskinesia, have emerged through the work of several groups over the last decade. Read More

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Clinical and electrophysiological predictors of behavioral disorders in patients with benign childhood epilepsy with centrotemporal spikes.

Epilepsy Behav 2021 08 28;121(Pt A):108037. Epub 2021 May 28.

Department of Pediatrics, Division of Child Neurology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.

Purpose: Long-term seizure and developmental outcomes of benign childhood epilepsy with centrotemporal spikes (BECTS) are thought to be good. Studies have shown that behavioral disorders may accompany BECTS. We aimed to investigate the frequency of behavioral disorders in patients with BECTS and evaluate their relationship to epilepsy features. Read More

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Clinical profile of patients with rolandic epilepsy at a clinic in rural Maharashtra.

J Family Med Prim Care 2021 Mar 8;10(3):1263-1266. Epub 2021 Apr 8.

Centre for Medical Genetics, Office No 250 and 251, Ecstasy Business Park, JSD Road, Mulund West, Mumbai, Maharashtra, India Centre at which study carried out: Dr Sunil Sable Children's Hospital and Saikrishna Child Neurology Centre, Shirdi -423109, Maharashtra, India.

Purpose: To describe the seizure pattern, treatment strategies and outcome in a series of children with Rolandic seizures or childhood epilepsy with centrotemporal spikes.

Materials And Methods: Patients were defined as Rolandic epilepsy if on electroencephalographic studies high voltage spike and waves were seen in centrotemporal areas, could be followed by slow waves, often activated on sleep and could shift from one side to other or be secondarily generalized. Typical (TRS) or benign were those with normal intellect. Read More

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