369 results match your criteria Benign Vulvar Lesions

Primary Benign Phyllodes Tumor of The Vulva: Case Report and Review of Literature.

Eur J Breast Health 2019 Jul 1;15(3):196-199. Epub 2019 Jul 1.

Department of Gynecology and Obstetrics, Ahi Evran University Training and Research Hospital, Kırşehir, Turkey.

Phyllodes tumor (PT) of the vulva is very rarely seen and has been reported in only 17 cases in English literature. It is still uncertain that proliferative mammary gland lesions including PT in the anogenital region originate from ectopic breast tissue or from local adnexal structures. We report a case of primary benign PT of the vulva in a 41-year-old female patient. Read More

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Angiofibroma of the Vagina Presenting with Abnormal Vaginal Bleeding: A Case Report from Ethiopia and Review of the Literature.

Case Rep Obstet Gynecol 2019 2;2019:1486387. Epub 2019 Jun 2.

Department of Obstetrics and Gynecology, Jimma University, Ethiopia.

Background: Angiofibroma is an uncommon type of vascular benign tumor that is made up of blood vessels and fibrous (connective) tissue. First described in 1997, it usually occurs in middle aged females and is clinically often thought to represent a cyst. Unlike most of the other site specific vulvovaginal mesenchymal lesions, cellular angiofibroma has a marked predilection for the vulva with only occasional examples reported in the vagina. Read More

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Several genotypes, one phenotype: PIK3CA/AKT1 mutation-negative hidradenoma papilliferum show genetic lesions in other components of the signalling network.

Pathology 2019 Jun 19;51(4):362-368. Epub 2019 Apr 19.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

About 60-70% of hidradenoma papilliferum (HP), a benign tumour of the anogenital region, were recently described to harbour mutations in major driver genes of the PI3K/AKT/MAPK-signalling pathways. However, the underlying genetic defects of the non-mutant cases are still unknown. Using a 409 gene panel, we employed targeted next generation sequencing to investigate the mutational landscape in a cohort of seven PI3K/AKT-negative cases and five cases with known hotspot mutations in either PIK3CA or AKT1. Read More

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A pregnant woman with condyloma acuminatum on the vaginal orifice, areola, groin, and umbilicus.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):310-312

Infectious Disease Center, Peking University Ditan Teaching Hospital; Department of Dermatology and Venereology, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China.

Condyloma acuminatum (CA) is a benign tumor primarily caused by infection with human papillomavirus (HPV) type-6 or type-11, lesions of which are most frequently found on the genital, perianal squamous mucosa, and skin. CA outside the anogenital region is not common. Here, we report a case showing simultaneous presence of CA on the vaginal orifice, areola, groin, and umbilicus in a 32-year-old pregnant woman. Read More

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Giant Fibroepithelial Polyp of Vulva: A Case Report and Review of Literature.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):127-130

Department of Gynecology and Obstetrics, Clinical Hospital, Tetovo, Republic of Macedonia.

Fibroepithelial stromal polyps of vulva are the type of mesenchymal lesion that typically occurs in women of reproductive period. They are common, usually small and hystologically benign. Larger lesions are rare and likely arise from proliferation of mesenchymal cells within the hormonally sensitive subepithelial stromal layer of the lower genital tract. Read More

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December 2018

Primary lymphangioma circumscriptum of the vulva presenting as warty plaques.

Australas J Dermatol 2019 Nov 27;60(4):305-307. Epub 2019 Feb 27.

Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Lymphangioma circumscriptum is a benign hamartomatous malformation involving the lymphatic system of skin and subcutaneous tissue. It can involve any part of the body with maximum predilection for proximal parts of limbs. Vulvar involvement is quite infrequent. Read More

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November 2019

Laparoscopic management of a large urethral leiomyoma.

Int Urogynecol J 2019 07 12;30(7):1211-1213. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, University of Brescia, Brescia, Italy.

Introduction And Hypothesis: A 42-year-old female presented with a 12-cm mass bulging the anterior vaginal wall and causing urgency urinary incontinence and bulk symptoms.

Methods: Imaging showed a tumor originating from the dorsal and cranial part of the urethra and developing in the vesicouterine space and vesicovaginal septum, dislocating the bladder ventrally and the uterus cranial-dorsally.

Results: Tranvaginal biopsy showed a benign leiomyoma. Read More

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Acquired angiokeratomas of the vulva.

Indian J Sex Transm Dis AIDS 2018 Jul-Dec;39(2):136-138

Department of Dermatology, Dr. D. Y. Patil Medical College and Hospital, Pune, Maharashtra, India.

Angiokeratomas are benign cutaneous lesions consisting of numerous ectatic blood vessels present in the superficial dermis and usually involving the scrotum. Although usually asymptomatic, they may be complicated by sporadic or profuse bleeding. We report the development of multiple vulvar angiokeratomas in a 40-year-old female after undergoing a perineoplasty successfully treated with electrocautery. Read More

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January 2019

Recurrent, nodular lesions over the vulva: A diagnostic challenge.

Indian J Sex Transm Dis AIDS 2018 Jul-Dec;39(2):124-126

Department of Dermatology, Father Muller Medical College, Mangalore, Karnataka, India.

Angiokeratomas are benign tumors characterized by proliferation and dilatation of blood vessels in the upper dermis. They are divided into widespread and localized forms. The localized forms are further classified as angiokeratoma of Fordyce, angiokeratoma circumscriptum neviforme, circumscribed angiokeratoma, and angiokeratoma of Mibelli, of which angiokeratoma of Fordyce is the most common. Read More

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January 2019

Distinction of Condylomata Acuminata From Vulvar Vestibular Papules or Pearly Penile Papules Using Ki-67 Immunostaining.

J Cutan Med Surg 2019 May/Jun;23(3):255-257. Epub 2018 Dec 17.

1 Departments of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Background: Ki-67 is an immunohistochemical stain used as a nuclear proliferation marker. It is nonspecific, and is expressed in all active phases of the cell cycle. Vulvar vestibular papules in women and pearly penile papules in men are benign fibrous papules on the genitals, are noninfectious, and do not require treatment. Read More

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December 2019

Adaptation of Alpha-Papillomavirus over Millennia.

Acta Cytol 2019 13;63(2):97-99. Epub 2018 Dec 13.

Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil,

Papillomaviruses (PVs) are a group of small DNA viruses that, with around 350 million years of evolution, acquired the capacity of infecting a broad range of vertebrates, including humans. To date, more than 300 PV types have been isolated. Viruses that have a long common evolutionary history with their host typically cause unapparent infections. Read More

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Multiple Epidermolytic Acanthomas: Rare Vulval Lesions Which May be Mistaken for Viral Warts.

Int J Gynecol Pathol 2020 Jan;39(1):93-96

Epidermolytic acanthoma is a rare benign lesion that most often presents as a solitary or multiple small papular lesions on the trunk, face, limbs or external male genitalia. Only a small number of cases have been reported occurring on the vulva and clinically and histologically they may mimic and be misdiagnosed as viral warts. We report 2 cases of multiple epidermolytic acanthomas localized to the vulva. Read More

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January 2020

A Case Report of Scrotal Rejuvenation: Laser Treatment of Angiokeratomas of the Scrotum.

Philip R Cohen

Dermatol Ther (Heidelb) 2019 Mar 26;9(1):185-192. Epub 2018 Nov 26.

San Diego Family Dermatology, National City, CA, USA.

Scrotal rejuvenation encompasses not only the functional quality but also the aesthetic appearance of the scrotum. It includes medical therapy and procedural interventions to improve scrotal conditions that require morphologic restoration and/or aesthetic alteration. Rejuvenation of the scrotum may be appropriate for aging-related and non-aging-related changes concerning the hair (alopecia and hypertrichosis), the morphology (laxity and wrinkles), and/or the vascularity (angiokeratoma) of the scrotum. Read More

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Melanocytic lesions - Staying out of trouble.

Thomas Brenn

Ann Diagn Pathol 2018 Dec 27;37:91-102. Epub 2018 Sep 27.

Department of Pathology & Laboratory Medicine, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary, AB T2L 2K8, Canada; Department of Medicine, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary, AB T2L 2K8, Canada; The Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary AB T2L 2K8, Canada; Department of Pathology, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, United Kingdom. Electronic address:

The diagnosis of melanocytic tumors is notoriously difficult and represents one of the most challenging areas in surgical pathology associated with significant risk for litigation. One reason is the wide morphologic spectrum of melanocytic tumors and the fact that many histological features are shared by both benign melanocytic nevi and melanoma. Awareness of the many morphologic variations and variants of nevi and melanoma, their clinical setting, immunohistochemical phenotype and genetic profile is necessary for the correct diagnosis. Read More

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December 2018

Granular cell tumor: A report of three cases and review of literature.

Cancer Biomark 2018 ;23(2):173-178

Department of Obstetrics and Gynecology, The Hongqi Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157000, Heilongjiang, China.

Objective: In order to improve the understanding of granular cell tumor and avoid missing the best time of treatment, we report three patients with rare granular cell tumors admitted to our hospital in the past 10 years.

Methods: The characteristics, methods of treatment, postoperative pathological results and follow-up results of three cases of granular cell tumor were analyzed; and literatures related to granular cell tumors were reviewed.

Results: All patients underwent surgical treatment, and the excised lesions were sent to the laboratory for testing. Read More

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February 2019

Detection of bovine papillomavirus type 2 DNA in calf conjunctival myofibroblastoma.

J Vet Med Sci 2018 Nov 30;80(10):1544-1548. Epub 2018 Aug 30.

Hokkaido Research Station, National Institute of Animal Health, National Agriculture and Research Organization, 4 Hitsujigaoka, Toyohira, Sapporo, Hokkaido 062-0045, Japan.

An 8-month-old male Japanese Black calf was referred for the evaluation of a slow-growing conjunctival mass in the right eye. A superficial keratectomy was performed followed by recurrence on two occasions. No metastases were found in surrounding tissues. Read More

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November 2018

Evaluation of large clinically atypical vulvar pigmentation with RCM: atypical melanosis or early melanoma?

J Eur Acad Dermatol Venereol 2019 Jan 12;33(1):84-92. Epub 2018 Jul 12.

Dermatology Department, Centre Hospitalier de Lyon Sud, Hospices civils de Lyon, Université Claude Bernard Lyon 1, Pierre Bénite, France.

Background: Vulvar melanosis can occasionally be clinically challenging by mimicking an early melanoma.

Objective: To report our experience of initial evaluation and follow-up in this peculiar subset of vulvar melanosis using reflectance confocal microscopy (RCM).

Methods: We retrospectively evaluated 18 consecutive cases referred for atypical vulvar pigmentation or for which melanoma was considered and that underwent both RCM examination and histopathological assessment. Read More

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January 2019

Large Vaginal Varicosities in the Setting of Pregnancy without Known Hepatic or Vascular Risks: A Case Report and Review of the Literature.

Case Rep Obstet Gynecol 2018 22;2018:2394695. Epub 2018 Jan 22.

School of Medicine, Loma Linda University, Loma Linda, CA, USA.

Pregnancy may cause the onset of vaginal or vulvar varicosities that may be a concern for hemorrhage risk during childbirth. A 38-year-old female G4P1112 at 34 weeks and 1 day was referred to an outpatient OB/Gyn clinic for evaluation of a large vaginal mass. The referring provider had concern for malignancy. Read More

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January 2018

Ultrasonography of benign vulvar lesions.

Ultrasonography 2018 Oct 13;37(4):355-360. Epub 2018 Feb 13.

Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong.

With the increasing applications of ultrasonography in the field of dermatology, this imaging modality can be extended to identify and characterize common vulvar lesions, with a particular focus on their location, size, vascularity, and content. This pictorial essay provides an introduction to vulvar ultrasonography, including technical considerations, ultrasonographic anatomy, and the ultrasonographic appearances of some vulvar conditions. Read More

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October 2018

Pediatric Granular Cell Tumors of the Vulva: A Report of 4 Cases and a Review of the Literature.

J Pediatr Adolesc Gynecol 2018 Jun 3;31(3):311-314. Epub 2018 Jan 3.

Department of Gynecology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts.

Background: Granular cell tumors (GCTs) are rare soft tissue lesions that can involve the female genital tract, including the vulva. Although malignant tumors are aggressive and uncommon, benign and atypical lesions still have associated risks, including recurrence and multisite development.

Cases: Four cases of pediatric vulvar GCT are presented, including 1 atypical and 3 benign tumors. Read More

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Comparison of F-FDG PET/MRI and MRI alone for whole-body staging and potential impact on therapeutic management of women with suspected recurrent pelvic cancer: a follow-up study.

Eur J Nucl Med Mol Imaging 2018 04 21;45(4):622-629. Epub 2017 Nov 21.

Medical Faculty, Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, D-45147, Essen, Germany.

Purpose: To evaluate the diagnostic performance of F-FDG PET/MRI for whole-body staging and potential changes in therapeutic management of women with suspected recurrent pelvic cancer in comparison with MRI alone.

Methods: Seventy-one consecutive women (54 ± 13 years, range: 25-80 years) with suspected recurrence of cervical (32), ovarian (26), endometrial (7), vulvar (4), and vaginal (2) cancer underwent PET/MRI including a diagnostic contrast-enhanced MRI protocol. PET/MRI and MRI datasets were separately evaluated regarding lesion count, localization, categorization (benign/malignant), and diagnostic confidence (3-point scale; 1-3) by two physicians. Read More

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Vulvar Nodules: A Rare Presentation of Mastocytosis.

J Pediatr Adolesc Gynecol 2018 Apr 21;31(2):156-157. Epub 2017 Nov 21.

Department of Obstetrics and Gynecology, Division of Pediatric and Adolescent Gynecology, UT Southwestern Medical Center, Children's Health, Dallas, Texas.

Background: Mastocytosis is a rare benign disorder characterized by the finding of mast cells in the skin and other organs, occurring in adult as well as pediatric age groups. The cutaneous form is the most common presentation in childhood and is rarely located on the vulva.

Case: A 9-year-old prepubertal girl presented with bilateral vulvar nodules found incidentally by her pediatrician. Read More

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Nodular Hyperplasia of the Bartholin Gland, A Benign Mimicker of Aggressive Angiomyxoma: A Case Series and Literature Review.

Int J Gynecol Pathol 2018 Nov;37(6):554-558

Department of Pathology and Microbiology (Y.A.T.), University of Nebraska Medical Center, Omaha, Nebraska; Department of Pathology and Laboratory Medicine (Y.A.T., W.D.L., S.E.S.), The Warren Alpert Medical School of Brown University and Women & Infants Hospital, Providence, Rhode Island.

Nodular hyperplasia (NH) of the Bartholin gland is an exceedingly rare benign solid lesion of the female genital tract that can mimic the Bartholin gland cyst clinically. The histologic criteria for NH were established in 1998 by Koenig and Tavassoli. In this case series, we describe 4 cases of NH from Women and Infants Hospital in Rhode Island. Read More

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November 2018

Clinician's Update on the Benign, Premalignant, and Malignant Skin Tumours of the Vulva: The Dermatologist's View.

Int Sch Res Notices 2017 25;2017:2414569. Epub 2017 Jul 25.

Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.

Correct and rapid diagnosis of skin tumours often requires biopsy and histopathological examination to differentiate benign lesions such as seborrhoeic keratoses or melanocytic naevi from premalignant and malignant lesions such as malignant melanoma. Particularly, to the untrained eye, any benign skin tumour-pigmented or nonpigmented-is easily mistaken for a malignant lesion. Qualified clinical evaluation is paramount in order to reduce the frequency of unwarranted skin biopsies. Read More

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Vulvar Neoplasms, Benign and Malignant.

Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352

Bethesda Dermpath Laboratory, 1730 Elton Road, Suite 11, Silver Spring, MD 20903, USA; Anne Arundel Dermatology, Towson, MD 21204, USA; Pathology, Johns Hopkins University, 4940 Bayview Medical Center, Eastern Avenue, Baltimore, MD 21224, USA. Electronic address:

Cutaneous vulvar neoplasms are commonly encountered at gynecology visits, with 2% of women having a benign vulvar melanocytic nevus and 10% to 12% of nevi being vulvar. High-grade squamous intraepithelial lesions (vulvar intraepithelial neoplasia 2 or 3) occurs in 5 per 100,000 women, with increasing incidence in the past 30 years. The recognition of these lesions and differentiation between benign, premalignant, and malignant stages are crucial for adequate diagnosis, clinical monitoring, and treatment. Read More

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September 2017

Urologic Dermatology: a Review.

Curr Urol Rep 2017 Aug;18(8):62

Virginia Mason Medical Center, Seattle, WA, USA.

Purpose Of Review: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic. Read More

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A Rare Case of Intravesical Angiomyofibroblastoma.

Urology 2017 Aug 11;106:e15-e18. Epub 2017 May 11.

Department of Pathology, Ekopath Metropolis Lab Services Pvt. Ltd., Guwahati, Assam, India.

Objective: To study the first reported case of intravesical angiomyofibroblastoma (AMFB). AMFB is an uncommon benign mesenchymal lesion, mostly described in the lower female genital tract, especially in the vulva and less commonly in the vagina. It is rarely seen in the male genital tract. Read More

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Bilateral Giant Fibroepithelial Labial Mass: A Case Report.

J Obstet Gynaecol Can 2017 Jul 6;39(7):564-566. Epub 2017 May 6.

Sir Sanusi Specialist Hospital, Kano, Nigeria.

Background: Fibro-epithelial polyps are benign soft tissue lesions that occur in a wide variety of sites, including the lower female genital tract. They exhibit a wide range of morphologic appearances and can be misinterpreted as malignant. These polyps therefore pose adiagnostic challenge to both the clinician and the pathologist. Read More

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Study of Selected BRCA1, BRCA2, and PIK3CA Mutations in Benign and Malignant Lesions of Anogenital Mammary-Like Glands.

Am J Dermatopathol 2017 May;39(5):358-362

*Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint Petersburg, Russia; †Department of Pathology, Medical Faculty, Saint-Petersburg State University, Saint-Petersburg, Russia; ‡Department of Pathology, Saint-Petersburg Medico-Social Institute, Saint Petersburg, Russia; Departments of §Pathology, and ¶Tumor Growth Biology, Petrov's Research Institute of Oncology, Saint Petersburg, Russia; ‖Department of Medical Genetics, Saint Petersburg Pediatric Medical University, Saint Petersburg, Russia; **Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; and ††Bioptical Laboratory, Pilsen, Czech Republic.

Anogenital mammary-like glands (AGMLGs) are nowadays considered a normal component of the anogenital area. Lesions involving AGMLGs are histopathologically very similar to their mammary counterparts, but the information on molecular biological mechanisms in these vulvar/perianal tumors is scarce. Mutations in the PI3K-AKT cascade have been found in hidradenoma papilliferum. Read More

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