646 results match your criteria Beneficial microbes[Journal]


Modulation of Toll-like receptor-mediated innate immunity in bovine intestinal epithelial cells by lactic acid bacteria isolated from feedlot cattle.

Benef Microbes 2020 May 4;11(3):269-282. Epub 2020 May 4.

Reference Centre for Lactobacilli (CERELA-CONICET), Chacabuco 145, San Miguel de Tucuman, 4000 Tucuman, Argentina.

The ability of lactobacilli isolated from feedlot cattle environment to differentially modulate the innate immune response triggered by Toll-like receptors (TLRs) activation in bovine intestinal epithelial (BIE) cells was evaluated. BIE cells were stimulated with CRL2069, CRL2074, CRL2085 or CRL2084 and challenged with heat-stable pathogen associated molecular patterns (PAMPs) from enterotoxigenic (ETEC) to induce the activation of TLR4 or with polyinosinic:polycytidylic acid (poly(I:C)) to activate TLR3. Type I interferons, cytokines, chemokines and negative regulators of TLR signalling were studied by RT-PCR. Read More

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http://dx.doi.org/10.3920/BM2019.0189DOI Listing

Are probiotics an appropriate treatment option for all women?

Authors:
N C Rubas

Benef Microbes 2020 May 4;11(3):303. Epub 2020 May 4.

John A Burns School of Medicine, University of Hawaii, 651 Ilalo Street, Honolulu HI, 96813, USA.

The recently published article by P. Tsimaris (2019) gave great prospective insight into non-traditional clinical applications of probiotic use as alternative and/or complementary therapeutics to traditional antibiotics for treatment of vulvovaginitis. However, these findings are too broad to be generalised as a treatment option for all women. Read More

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http://dx.doi.org/10.3920/BM2020.0034DOI Listing

The effect of probiotics on prevention of upper respiratory tract infections in the paediatric community - a systematic review.

Benef Microbes 2020 May 21;11(3):201-211. Epub 2020 Apr 21.

Acıbadem Mehmet Ali Aydınlar University, School of Medicine, Department of Pediatric Infectious Diseases, Istanbul 34303, Turkey.

Prevention of acute upper respiratory tract infections (URTIs) is becoming an increasingly important concept in public health application due to the increase in antibiotic resistance. Probiotics have been shown to have some effect on prevention in various reviews. In this study we aimed to re-asses the effect of probiotics as there has been a substantial increase in literature regarding the effects and safety of probiotics in the paediatric population. Read More

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http://dx.doi.org/10.3920/BM2019.0119DOI Listing

Revealing new leads for the impact of galacto-oligosaccharides on gut commensals and gut health benefits through text mining.

Benef Microbes 2020 May 17;11(3):283-302. Epub 2020 Apr 17.

Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands.

Galacto-oligosaccharides (GOS) are linked to various health benefits, such as the relief of symptoms of constipation. Part of the beneficial effects of GOS are thought to be the consequence of their bifidogenic effect, stimulating the growth of several species . However, GOS may exert additional effects by directly stimulating other bacterial species or by effects that bifidobacteria may have on other commensals in the gut. Read More

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http://dx.doi.org/10.3920/BM2019.0105DOI Listing

Effect of UFMG A-905 in a murine model of food allergy.

Benef Microbes 2020 May 8;11(3):255-268. Epub 2020 Apr 8.

Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, Av. Antônio Carlos, 6627, 30270-901 MG, Brazil.

Food allergy is triggered when there is an abnormal activation of the immune system by food allergens. Currently, there is no curative therapy for this pathological condition. Due to the immunomodulatory properties of probiotics they are potential candidates as therapeutic tools for food allergy. Read More

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http://dx.doi.org/10.3920/BM2019.0113DOI Listing

Survival of a probiotic-containing product using capsule-within-capsule technology in an model of the stomach and small intestine (TIM-1).

Benef Microbes 2020 Apr 8:1-8. Epub 2020 Apr 8.

Keller Consulting Group, 2417 Beachwood Blvd., Beachwood, OH 44122, USA.

The aim of the research was to compare the survival of a blend of five probiotic strains (2 bifidobacteria and 3 lactobacilli) in a capsule within capsule (Duocap) containing Ahiflower oil, as compared to the strains in the powder (with or without Ahiflower oil), or the strains when present in the inner capsule only. This was tested in a validated, dynamic model of the stomach and small intestine (TIM-1), simulating human adults. Experiments were performed both in the gastric compartment of the model, as well as in the complete system (stomach + small intestine). Read More

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http://dx.doi.org/10.3920/BM2019.0209DOI Listing

Immune modulatory capacity of probiotic lactic acid bacteria and applications in vaccine development.

Benef Microbes 2020 May 27;11(3):213-226. Epub 2020 Mar 27.

Razi Vaccine and Serum Research Institute (RVSRI), Agricultural Research, Education and Extension Organization (AREEO), P.O. Box 31975/148, Karaj, Iran.

Vaccination is one of the most important prevention tools providing protection against infectious diseases especially in children below the age of five. According to estimates, more than 5 million lives are saved annually by the implementation of six standard vaccines, including diphtheria, hepatitis B, type b, polio, tetanus and yellow fever. Despite these efforts, we are faced with challenges in developing countries where increasing population and increasing disease burden and difficulties in vaccine coverage and delivery cause significant morbidity and mortality. Read More

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http://dx.doi.org/10.3920/BM2019.0121DOI Listing

Guidelines for best practice in placebo-controlled experimental studies on probiotics in rodent animal models.

Benef Microbes 2020 May 27;11(3):245-254. Epub 2020 Mar 27.

Department of Psychology and Neuroscience, Dalhousie University, 1355 Oxford St., Halifax NS, B3M 4R2, Canada.

In the absence of established best practice standards in the probiotic field for reducing the risk of bacterial transfer between experimental groups, we developed protocols and methods to ensure the highest quality and interpretability of results from animal studies, even when performed in non-conventional animal care facilities. We describe easily implementable methods for reducing cross-contamination during animal housing, behavioural testing, and euthanasia, along with highlighting protocols for contamination detection in experimental subjects and laboratory areas using qPCR. In light of the high cross-contamination risks between animals during experiments involving probiotics, constant vigilance in animal care and research protocols is critical to ensure valid and reliable research findings. Read More

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http://dx.doi.org/10.3920/BM2019.0144DOI Listing

Effects of CECT5716 Lc40 on infant growth and health: a randomised clinical trial in nursing women.

Benef Microbes 2020 May 27;11(3):235-244. Epub 2020 Mar 27.

Biosearch Life SA, Camino de Purchil 66, 18004 Granada, Spain.

The breast milk microbiota has been described as a source of bacteria for infant gut colonisation. We studied the effect of CECT5716 (Lc40) on growth and infection incidence of the infants, when the probiotic is administrated to the mothers. Moreover, whether such effects might depend on the interaction between the mother or infant microbiota and the probiotic administration. Read More

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http://dx.doi.org/10.3920/BM2019.0180DOI Listing

Xylo-oligosaccharides from sugarcane show prebiotic potential in a dynamic computer-controlled model of the adult human large intestine.

Benef Microbes 2020 Mar 25;11(2):191-200. Epub 2020 Mar 25.

Keller Consulting Group, 2417 Beachwood Blvd., Beachwood, OH 44122, USA.

The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled model of the colon (TIM-2) simulating human adults. In two sets of experiments, each with a different microbiota, 3 different doses of XOS were tested at 1.0 g/day, 1. Read More

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http://dx.doi.org/10.3920/BM2019.0159DOI Listing

Retail refrigerated probiotic foods and their association with evidence of health benefits.

Benef Microbes 2020 Mar 25;11(2):131-133. Epub 2020 Mar 25.

Department of Family Medicine, Georgetown University, 3800 Reservoir Rd, Washington, DC 20007, USA.

Probiotic usage in food is widespread and growing. The objective of this study was to determine the percentage of probiotic food products sold in the refrigerated section of retail grocery stores in the Washington DC area that we could link to evidence of any health benefit. We surveyed refrigerated sections of eight large grocery stores representing five national chains for probiotic products. Read More

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http://dx.doi.org/10.3920/BM2019.0162DOI Listing

S27 from chicken faeces as a potential probiotic to replace antibiotics: evidence.

Benef Microbes 2020 Mar 5;11(2):163-173. Epub 2020 Mar 5.

Laboratoire de Microbiologie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia 06000, Algeria.

This study reports the probiotic attributes of strains isolated from chicken faeces and mainly their capabilities to prevent infectious diseases and improve chicken production performance. Thus, 22 strains were isolated from 50 chickens' faeces samples and assessed for their resistance to gastric acidity (pH 0.5, 1, 1. Read More

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http://dx.doi.org/10.3920/BM2019.0116DOI Listing

Probiotics, prebiotics and synbiotics: useful for athletes and active individuals? A systematic review.

Benef Microbes 2020 Mar 19;11(2):135-149. Epub 2020 Feb 19.

International Chair of Sport Medicine, Faculty of Medicine, Catholic University of Murcia, Campus de los Jerónimos, 30107, Murcia, Spain.

The purpose of this review was to synthesise available knowledge on the main health effects associated with the use of probiotics, prebiotics and/or synbiotics in athletes and active individuals, including their effects on the immune system, oxidative stress, the gastrointestinal and respiratory symptoms, as well as other possible clinical outcomes. A systematic and comprehensive search in electronic databases, including Web of Science (WOS, Scielo), PubMed-MEDLINE, Biblioteca virtual de la Salud (LILACS, IBECS), EBSCO (Academic Search Complete CINAHL; SPORTDiscus) and Cochrane Library, focused on generic articles about probiotics, prebiotics and/or synbiotics and their functionality and effects on human health. The search process was completed using the keywords: 'probiotics', 'prebiotics', 'synbiotics', 'athletes' and 'health'. Read More

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http://dx.doi.org/10.3920/BM2019.0076DOI Listing

Structural changes in gut microbiome after Ramadan fasting: a pilot study.

Benef Microbes 2020 May 19;11(3):227-233. Epub 2020 Feb 19.

Gazi University, Medical Faculty, Department of Internal Medicine, Division of Gastroenterology, Besevler, Ankara 06560, Turkey.

It has been largely accepted that dietary changes have an effect on gut microbial composition. In this pilot study we hypothesised that Ramadan fasting, which can be considered as a type of time-restricted feeding may lead to changes in gut microbial composition and diversity. A total of 9 adult subjects were included in the study. Read More

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http://dx.doi.org/10.3920/BM2019.0039DOI Listing

Effect of fructans, prebiotics and fibres on the human gut microbiome assessed by 16S rRNA-based approaches: a review.

Benef Microbes 2020 Mar 19;11(2):101-129. Epub 2020 Feb 19.

Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave, St. Paul, MN 55108, USA.

The inherent and diverse capacity of dietary fibres, nondigestible oligosaccharides (NDOs) and prebiotics to modify the gut microbiota and markedly influence health status of the host has attracted rising interest. Research and collective initiatives to determine the composition and diversity of the human gut microbiota have increased over the past decade due to great advances in high-throughput technologies, particularly the 16S ribosomal RNA (rRNA) sequencing. Here we reviewed the application of 16S rRNA-based molecular technologies, both community wide (sequencing and phylogenetic microarrays) and targeted methodologies (quantitative PCR, fluorescent hybridisation) to study the effect of chicory inulin-type fructans, NDOs and specific added fibres, such as resistant starches, on the human intestinal microbiota. Read More

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http://dx.doi.org/10.3920/BM2019.0082DOI Listing

Beneficial effect of on rumen digestion and fermentation.

Benef Microbes 2020 Feb 17;11(1):91-99. Epub 2019 Dec 17.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China P.R.

As a member of photosynthetic bacteria, , which has extraordinary metabolic versatility, has been applied as one of potential probiotics in feed industry. To explore whether can increase rumen microbial viability and thus improve microbial fermentation, a 2×5 factorial experiment was conducted to evaluate the effect of at dose rates of 0, 1.3, 2. Read More

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http://dx.doi.org/10.3920/BM2019.0044DOI Listing
February 2020

Treatment with 5 attenuates intestinal damage and inflammatory response in experimental colitis.

Benef Microbes 2020 Feb 17;11(1):47-57. Epub 2019 Dec 17.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.

This study evaluated the effects of 5 on the intestinal mucosa and inflammatory response in experimental colitis. Colitis was induced by administration of 3.5% dextran sodium sulphate (DSS) solution for 7 days. Read More

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http://dx.doi.org/10.3920/BM2019.0098DOI Listing
February 2020

Foreword - 10 years of Beneficial Microbes.

Authors:
Koen Venema

Benef Microbes 2020 02;11(1):1-3

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http://dx.doi.org/10.3920/BM2020.x001DOI Listing
February 2020

Altered microbial community structure and metabolism in cow's milk allergic mice treated with oral immunotherapy and fructo-oligosaccharides.

Benef Microbes 2020 Feb 17;11(1):19-32. Epub 2019 Dec 17.

Utrecht Institute for Pharmaceutical Sciences, Department of Pharmacology, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, the Netherlands.

Previously, we showed enhanced efficacy of oral immunotherapy (OIT) using fructo-oligosaccharides (FOS, prebiotics) added to the diet of cow's milk allergic mice indicated by a reduction in clinical symptoms and mast cell degranulation. Prebiotics are fermented by gut bacteria, affecting both bacterial composition and availability of metabolites (i.e. Read More

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http://dx.doi.org/10.3920/BM2019.0024DOI Listing
February 2020

IS-10506 promotes renal tubular regeneration in pyelonephritic rats.

Benef Microbes 2020 Feb 17;11(1):59-66. Epub 2019 Dec 17.

Department of Child Health, Faculty of Medicine, Universitas Airlangga - Dr Soetomo General Hospital, Jalan Mayjend Prof Dr Moestopo 6-8, Surabaya 60286, Indonesia.

IS-10506 is a novel probiotic isolated from Indonesian traditional fermented buffalo milk . Probiotics are clinically proven to be effective in accelerating recovery after urinary tract infection (UTI) and in decreasing recurrent UTI in children with or without structural disorders of the urinary tract. This study aimed to investigate the role of the probiotic IS-10506 in activating and regenerating renal epithelial stem cells in pyelonephritic rats. Read More

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http://dx.doi.org/10.3920/BM2019.0036DOI Listing
February 2020

Effects of subsp. HN019 on ligature-induced periodontitis in rats with experimental rheumatoid arthritis.

Benef Microbes 2020 Feb 17;11(1):33-46. Epub 2019 Dec 17.

Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av. do Cafe, s/n 14040-904, Ribeirao Preto, SP, Brazil.

The purpose of this study was to evaluate the effects of systemic administration of the probiotic subsp. HN019 (HN019) on ligature-induced periodontitis in rats with experimental rheumatoid arthritis (RA). 28 rats were divided into four groups (n=7): RA (rheumatoid arthritis), RA/PROB (probiotic), RA/EP (experimental periodontitis) and RA/EP/PROB. Read More

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http://dx.doi.org/10.3920/BM2019.0038DOI Listing
February 2020

Recombinant NZ3900 expressing bioactive human FGF21 reduced body weight of Db/Db mice through the activity of brown adipose tissue.

Benef Microbes 2020 Feb 17;11(1):67-78. Epub 2019 Dec 17.

School of Pharmaceutical Sciences, Key Laboratory of State Ministry of Education, Key Laboratory of Henan province for Drug Quality Control and Evaluation, Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, 100 Ke xue Avenue, Zhengzhou, Henan 450001, China P.R.

Fibroblast growth factor 21 (FGF21), a metabolism regulator, has an important effect on metabolic diseases, such as obesity and diabetes. It is also expressed in mice, and the murine source has high homology with human FGF21. Recently, it has been extensively studied and has become a potential drug target for the treatment of metabolic diseases. Read More

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http://dx.doi.org/10.3920/BM2019.0093DOI Listing
February 2020

Intravaginal administration of gelatine capsules containing freeze-dried autochthonous lactobacilli: a double-blind, randomised clinical trial of safety.

Benef Microbes 2020 Feb 17;11(1):5-17. Epub 2019 Dec 17.

Centro de Referencia para Lactobacilos (CERELA)-CONICET, Chacabuco 145, 4000 San Miguel de Tucumán, Tucumán, Argentina.

Vaginal lactobacilli (LAB) in probiotic formulas constitute a promising alternative for microbiome reconstitution and for the prevention and treatment of urogenital infections. A double-blind, randomised clinical trial was conducted to assess the safety of LAB-gelatine capsules vaginally administered to healthy sexually active women. Participants were randomised into three groups: intervention A: CRL1324, CRL1263 and CRL1307; intervention B: CRL1332, CRL1256 and CRL1320; and intervention C: placebo. Read More

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http://dx.doi.org/10.3920/BM2019.0081DOI Listing
February 2020

probiotics improved the gut microbiota profile of a Alzheimer's disease model and alleviated neurodegeneration in the eye.

Benef Microbes 2020 Feb 14;11(1):79-89. Epub 2020 Jan 14.

School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia.

Alzheimer's disease (AD) is a progressive disease and one of the most common forms of neurodegenerative disorders. Emerging evidence is supporting the use of various strategies that modulate gut microbiota to exert neurological and psychological changes. This includes the utilisation of probiotics as a natural and dietary intervention for brain health. Read More

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http://dx.doi.org/10.3920/BM2019.0086DOI Listing
February 2020

Blood protein polymorphisms and the gut bacteria: impact of probiotic Narine on carriage in sheep.

Benef Microbes 2020 Mar 7;11(2):183-189. Epub 2020 Feb 7.

Health Promoting Naturals Laboratory, School of Environmental and Biological Sciences, Rutgers State University, New Brunswick, NJ 08901-8520, USA.

Related to previous reports on correlations between an animal's genotype, its commensal microbiota, and the ability to resist infections, the aim of the current study was to investigate the associations between sheep genotype and 5-methylcytosine (5-mC) DNA methylation patterns, sheep genotype and cell surface hydrophobicity of sheep gut commensal bacteria. In addition, the effect of the probiotic strain INMIA 9602 Er 317/402 (probiotic formulation Narine) on carriage in sheep at Armenian farms was also investigated. Allelotypes and genotypes of different pathogen-sensitive sheep breeds from Armenian farms were studied based on genetic markers of blood transferrin, albumin, and ceruloplasmin. Read More

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http://dx.doi.org/10.3920/BM2019.0138DOI Listing

(YT001) supplementation for the control of and modulation of the immune response of sheep.

Benef Microbes 2020 Mar 28;11(2):175-181. Epub 2020 Jan 28.

Universidade Federal de Pelotas (UFPel), Campus Universitário, S/N, Caixa Postal 354, CEP 96010-900, Pelotas, RS, Brazil.

Studies aiming at the development and evaluation of alternative methods to minimise losses caused by the gastrointestinal nematode are extremely important. Such research is essential, given the high morbidity rates among sheep and the significant mortality rates of lambs, allied to the low efficacy of commercial products for the control of this parasite. The purpose of this study was to evaluate the effect of the (YT001 - YEASTECH) on the control of and its modulation of the immune response in experimentally infected sheep. Read More

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http://dx.doi.org/10.3920/BM2019.0120DOI Listing

Human milk mycobiota composition: relationship with gestational age, delivery mode, and birth weight.

Benef Microbes 2020 Mar 28;11(2):151-162. Epub 2020 Jan 28.

Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Eskisehir 26480, Turkey.

Intestinal and human milk microbiota studies during infancy have shown variations according to geographical location, delivery mode, gestational age, and mother-related factors during pregnancy. In this study, we performed metagenomic mycobiota analyses of 44 transient and mature human milk among five different groups: mothers of normal spontaneous delivery-term (NS-T), caesarean delivery-term (CS-T), premature (PT), small for gestational age (SGA), and large for gestational age (LGA) infants. Fungi were detected in 80 out of the 88 samples. Read More

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http://dx.doi.org/10.3920/BM2019.0158DOI Listing

Postbiotics: facts and open questions. A position paper on the need for a consensus definition.

Benef Microbes 2019 Oct 7;10(7):711-719. Epub 2019 Aug 7.

Functional Foods Forum, Faculty of Medicine, University of Turku, Turun Yliopisto, Turku 20014, Finland.

The past definitions of probiotics and prebiotics have been reviewed and updated recently. According to these concepts, probiotics comprise live microorganisms that confer a health benefit on the host when administered in adequate amounts, whereas a prebiotic is a substrate that is selectively utilised by host microorganisms, conferring a health benefit. The words probiotics and prebiotics can be found on labels of many foods and supplements. Read More

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http://dx.doi.org/10.3920/BM2019.0015DOI Listing
October 2019

Could probiotics be the panacea alternative to the use of antimicrobials in livestock diets?

Benef Microbes 2019 Oct 27;10(7):773-799. Epub 2019 Aug 27.

Agriculture and Agri-Food Canada, 5403 1st Ave South, Lethbridge, AB T1J 4P4, Canada.

Probiotics are most frequently derived from the natural microbiota of healthy animals. These bacteria and their metabolic products are viewed as nutritional tools for promoting animal health and productivity, disease prevention and therapy, and food safety in an era defined by increasingly widespread antimicrobial resistance in bacterial pathogens. In contemporary livestock production, antimicrobial usage is indispensable for animal welfare, and employed to enhance growth and feed efficiency. Read More

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http://dx.doi.org/10.3920/BM2019.0059DOI Listing
October 2019

Safety and probiotic evaluation of two strains producing antioxidant compounds.

Benef Microbes 2019 Oct 16;10(7):759-771. Epub 2019 Sep 16.

SporeGen Ltd., Bourne Labs, Egham, Surrey, TW20 OEX, United Kingdom.

species are becoming increasingly relevant for use as probiotics or feed additives where their heat stability can ensure survival in the food matrix or enable long-term storage at ambient temperature. Some s species are pigmented and in this study, we have examined two strains, one (pigmented red) and the other (pigmented yellow) for their safety for potential use in humans as dietary supplements. In addition, we have set out to determine if they might confer any potential health benefits. Read More

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http://dx.doi.org/10.3920/BM2019.0040DOI Listing
October 2019

Effect of rice bran fermented with and on gut microbiome of mice fed high-sucrose diet.

Benef Microbes 2019 Oct 16;10(7):811-821. Epub 2019 Sep 16.

Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-city, Tokyo 108-8477, Japan.

To clarify the effect of rice bran (RB) and fermented RB (FRB) in a high-sucrose and low-dietary fibre diet on the gut microbiome, the bile acid-lowering capacity and caecal microbiota of ICR mice fed with 20% RB or FRB diets for two weeks were determined. The caecal microbiome was analysed by 16S rRNA gene amplicon sequencing. The bile acid-lowering capacity was high for FRB. Read More

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http://dx.doi.org/10.3920/BM2019.0072DOI Listing
October 2019

Association between blood omega-3 polyunsaturated fatty acids and the gut microbiota among breast cancer survivors.

Benef Microbes 2019 Oct 16;10(7):751-758. Epub 2019 Sep 16.

Division of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

Omega-3 polyunsaturated fatty acids (PUFAs) are essential nutrients demonstrated to have health benefits, such as decreasing the risk of coronary heart disease, improving parameters associated with metabolic syndrome, and decreasing anxiety symptoms and depression risk. Previous intervention studies indicated the association between blood or tissue PUFA levels and the gut microbiota; however, the details remain incompletely elucidated. We conducted a cross-sectional study to examine the association between PUFAs and the gut microbiota among breast cancer survivors. Read More

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http://dx.doi.org/10.3920/BM2019.0034DOI Listing
October 2019

Analysis of hypoxia-associated dendritic cells in colitic mice and effects of probiotics on IL-10 production in inflammatory dendritic-cells under hypoxia.

Benef Microbes 2019 Oct 3;10(7):801-810. Epub 2019 Jul 3.

Graduate School of Biosphere Science, Hiroshima University, 1-4-4 Kagamiyama, Higashi-hiroshima, Hiroshima 739- 8528, Japan.

The aim of this study was to analyse hypoxia-associated dendritic cells (DCs) in colitic mice and the effects of probiotics on interleukin (IL)-10 production in inflammatory DCs under hypoxic conditions. Extensive hypoxia was observed in the colonic mucosa of dextran sodium sulphate-induced colitic mice. Flow cytometric analysis demonstrated that hypoxia-inducible factor-1α DCs in colonic lamina propria (CLP) lymphocytes and mesenteric lymph nodes (MLN) were more abundant in colitic mice than those in controls. Read More

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http://dx.doi.org/10.3920/BM2018.0171DOI Listing
October 2019

Recovery of strain Shirota (LcS) from faeces of healthy Singapore adults after intake of fermented milk.

Benef Microbes 2019 Oct 24;10(7):721-728. Epub 2019 Jul 24.

Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117545, Singapore.

To validate survival of strain Shirota (LcS) during passage through the gastrointestinal tract of healthy Singaporean young adults, 21 participants (18-25 years old) were asked to consume a 100 ml of fermented milk drink containing 1.0×10 cfu/ml of LcS daily for 14 days, and to maintain their dietary habit and life style. During and at the end of the ingestion period, both culture method (identity confirmed by ELISA) and 16s rRNA sequencing results revealed that viable LcS (7. Read More

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http://dx.doi.org/10.3920/BM2018.0173DOI Listing
October 2019

Mining possible associations of faecal colonisation patterns with host adiposity and cardiometabolic markers in an adult population.

Benef Microbes 2019 Oct 29;10(7):741-749. Epub 2019 Sep 29.

Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece.

We aimed to evaluate colonisation patterns of in a Greek adult population and to investigate model-adjusted associations of with host adiposity and cardiometabolic markers. Participants (n=125) underwent anthropometric, dietary, physical activity and lifestyle evaluation. Blood sampling for determination of blood lipid indices, glucose metabolism, adiponectin, lipoprotein-associated phospholipase A (Lp-PLA), inflammation and oxidative stress parameters was also performed. Read More

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http://dx.doi.org/10.3920/BM2019.0033DOI Listing
October 2019

Probiotics maintain intestinal secretory immunoglobulin A levels in healthy formula-fed infants: a randomised, double-blind, placebo-controlled study.

Benef Microbes 2019 Oct 24;10(7):729-739. Epub 2019 Jul 24.

Department of Neonatology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China P.R.

Formula-fed infants are more susceptible to infectious diseases because they lack the maternal immune factors transferred from breast milk, while their own immune system is still immature. As timely probiotic administration was suggested to promote immune system development in formula-fed infants, this study aimed at assessing the safety and the effects of a probiotic supplement ( R0033, R0071, and R0052) on mucosal immune competence and digestive function in formula-fed infants. Healthy infants (3. Read More

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http://dx.doi.org/10.3920/BM2019.0025DOI Listing
October 2019

Effect of probiotic supplementation on cognitive function in children and adolescents: a systematic review of randomised trials.

Benef Microbes 2019 Dec 26;10(8):873-882. Epub 2019 Nov 26.

Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.

Available reviews have shown potential effects of probiotics on neurobehavioral outcomes through 'gut-brain axis' mechanism in adults. However, reviews on cognitive function in children and adolescents are lacking. Therefore, we conducted a systematic review of randomised controlled trials (RCTs) of the effect of probiotic supplementation on cognitive function in children and adolescents. Read More

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http://dx.doi.org/10.3920/BM2019.0068DOI Listing
December 2019

Association of life habits and fermented milk intake with stool frequency, defecatory symptoms and intestinal microbiota in healthy Japanese adults.

Benef Microbes 2019 Dec 4;10(8):841-854. Epub 2019 Dec 4.

Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan.

Few studies have examined the effects of smoking habit, the frequency of alcohol drinking, exercise, and fermented milk consumption on defecatory symptoms and gut microbiota composition, and particularly their interactive effects. We examined the effect of these lifestyle factors on bowel movements and gut microbiota composition in 366 healthy Japanese adults by analysis of covariance. Smoking did not affect defecatory symptoms but was negatively correlated with total bacteria and counts. Read More

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http://dx.doi.org/10.3920/BM2019.0057DOI Listing
December 2019

-fermented rice bran and rice bran supplementation affects the gut microbiome and metabolome.

Benef Microbes 2019 Dec 29;10(8):823-839. Epub 2019 Sep 29.

Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80521, USA.

This study investigated gut microbiota composition along with food, host, and microbial derived metabolites in the colon and systemic circulation of healthy mice following dietary rice bran and fermented rice bran intake. Adult male BALB/c mice were fed a control diet or one of two experimental diets containing 10% w/w rice bran fermented by or 10% w/w non-fermented rice bran for 15 weeks. Metabolomics was performed on the study diets (food), the murine colon and whole blood. Read More

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http://dx.doi.org/10.3920/BM2019.0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066528PMC
December 2019

GG and exert synergistic antipathogenic activity against enterotoxigenic .

Benef Microbes 2019 Dec 10;10(8):923-935. Epub 2019 Oct 10.

ProDigest bvba, Technologiepark 82, 9052 Ghent, Belgium.

Short-term colonic batch incubations were performed to elucidate the possible synergistic effects of GG (CNCM-I-4798) and (CNCM-I-1079) (associated in Smebiocta/Smectaflora Protect®) on the colonic microbial fermentation process, as well as their antipathogenic activity against enterotoxigenic (LMG2092) (ETEC). These incubations adequately simulate the native microbiota and environmental conditions of the proximal colon of both adult and toddler donors, including the colonic mucosal layer. Results indicated that both strains were capable of growing together without showing antagonistic effects. Read More

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http://dx.doi.org/10.3920/BM2019.0064DOI Listing
December 2019

Lactobacilli modulated AMPK activity and prevented telomere shortening in ageing rats.

Benef Microbes 2019 Dec 10;10(8):883-892. Epub 2019 Oct 10.

School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia.

This study aimed to evaluate the anti-ageing effects of different strains of lactobacilli putative probiotics on an ageing rat model as induced by D-galactose and a high fat diet. Male Sprague-Dawley rats were fed with high fat diet (54% kcal fat) and injected with D-galactose daily for 12 weeks to induce ageing. The effects of putative probiotic strains on age-related impairment such as telomere length, plasma lipid peroxidation, hepatic 5'adenosine monophosphate-activated protein kinase (AMPK) expression, as well as endurance performance were evaluated. Read More

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http://dx.doi.org/10.3920/BM2019.0058DOI Listing
December 2019

Tht 500101 changes gut microbiota and ameliorates hyperglycaemia, dyslipidaemia, and liver inflammation in streptozotocin-diabetic mice.

Benef Microbes 2019 Dec 4;10(8):901-912. Epub 2019 Dec 4.

Federal University of São Paulo (Unifesp), Institute of Science and Technology, Department of Science and Technology - São José Dos Campos, Rua Talim 330. Vila Nair, 12231-280 São José Dos Campos, SP, Brazil.

Type 1 diabetes mellitus (T1DM) is a disorder resulting from chronic autoimmune destruction of insulin-producing pancreatic β-cells, lack of insulin production and hyperglycaemia. The aim of this study was to evaluate the hypothesis that streptozotocin-diabetic mice treated with THT 500101 strain present improvement of glucose and triglycerides metabolism, reduction of liver inflammation concomitant with a beneficial impact in the gut microbiota profile. C57BL/6 male mice were randomly assigned into three groups: Control, Diabetes, Diabetes+Probiotic, and were euthanised 8 weeks after probiotic chronic administration. Read More

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http://dx.doi.org/10.3920/BM2019.0056DOI Listing
December 2019

Probiotics exert reciprocal effects on autophagy and interleukin-1β expression in infected intestinal epithelial cells via autophagy-related 16L1 protein.

Authors:
W-T Lai F-C Huang

Benef Microbes 2019 Dec 10;10(8):913-922. Epub 2019 Oct 10.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan ROC.

This study aimed to examine how probiotics affect autophagy and interleukin-1β (IL-1β) expression in -infected intestinal epithelial cells (IECs). The original Caco-2 cells and ATG16L1 siRNA-transfected Caco-2 cells were pretreated or left untreated with probiotics, including GG (LGG; ATCC 53103) and (BL; ATCC15697), and these cells were infected with wild-type serovar Typhimurium ( Typhimurium strain, SL1344). Western blot analysis was used to detect the conversion of microtubule-associated proteins 1A/1B light chain 3B (LC3)-I to LC3-II. Read More

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http://dx.doi.org/10.3920/BM2019.0046DOI Listing
December 2019

Effect of multi-strain probiotic (UB0316) in weight management in overweight/obese adults: a 12-week double blind, randomised, placebo-controlled study.

Benef Microbes 2019 Dec 4;10(8):855-866. Epub 2019 Dec 4.

Nanal Clinic, Anand Bhuvan, Gore wadi, Mahim (W), Mumbai 400016, India.

This clinical trial was carried out to assess the effects of multi-strain probiotic capsule (UB0316: UBLS-22, UBLC-42, , UBLP-40, UBLA-34, UBBr-01, Unique IS2 5×10 cfu each and fructo-oligosaccharide, 100 mg) on overweight/obesity-related parameters. Ninety subjects (age, 30-65 years; body mass index (BMI), 25-32 kg/m) were randomised into two groups, i.e. Read More

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http://dx.doi.org/10.3920/BM2019.0052DOI Listing
December 2019

Lactobacilli intra-tracheal administration protects from pulmonary infection in mice - a proof of concept.

Benef Microbes 2019 Dec 10;10(8):893-900. Epub 2019 Oct 10.

Univ Brest, Inserm, EFS, UMR 1078, GGB, 22 avenue Camille Desmoulins, 29200 Brest, France.

The spreading of antibiotic resistance is a major public health issue, which requires alternative treatments to antibiotics. Lactobacilli have shown abilities to prevent pneumonia in clinical studies when given by oral route, certainly through the gut-lung axis involvement. Rationally, respiratory administration of lactobacilli has been developed and studied in murine model, to prevent from respiratory pathogens. Read More

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http://dx.doi.org/10.3920/BM2019.0069DOI Listing
December 2019

Alleviation of vulvovaginitis symptoms: can probiotics lead the treatment plan?

Benef Microbes 2019 Dec;10(8):867-872

2nd Department of Obstetrics and Gynecology, Athens University, Medical School, Aretaieion Hospital, 76 Vassilissis Sofias Avenue, PC 11528, Athens, Greece.

Disruption of vaginal microbiota equilibrium promotes infectious clinical syndromes with annoying symptoms, such as vaginal discharge, odour, irritation, pruritus, and vulvar burning. Although identifying and eradicating the pathogen involved has been the standard of care, regional microbiota restoration with probiotics has been gaining ground in recent years. This study aimed to assess the effectiveness of topical treatment for patients exhibiting vaginal discomfort symptoms. Read More

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http://dx.doi.org/10.3920/BM2019.0048DOI Listing
December 2019

and its applications in medicine.

Authors:
Y Mu Y Cong

Benef Microbes 2019 Jul 17;10(6):679-688. Epub 2019 Jun 17.

Department of Clinical Laboratory, Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University, Luzhou, Sichuan 646000, China P.R.

is a probiotic bacterium that produces spores. Due to its excellent stability, it has been widely used in medicine, food and chemical industry. Recent studies have shown that has therapeutic effects on intestinal diseases, such as acute diarrhoea, irritable bowel syndrome, antibiotic-related diarrhoea, constipation and colitis via modulation of the microbiota composition, host immunity and metabolism. Read More

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http://dx.doi.org/10.3920/BM2019.0016DOI Listing
July 2019
3 Reads

and its applications in medicine.

Authors:
Y Mu Y Cong

Benef Microbes 2019 Jun 13:1-10. Epub 2019 Jun 13.

2 Department of Clinical Laboratory, Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University, Luzhou, Sichuan 646000, China P.R.

is a probiotic bacterium that produces spores. Due to its excellent stability, it has been widely used in medicine, food and chemical industry. Recent studies have shown that has therapeutic effects on intestinal diseases, such as acute diarrhoea, irritable bowel syndrome, antibiotic-related diarrhoea, constipation and colitis via modulation of the microbiota composition, host immunity and metabolism. Read More

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http://dx.doi.org/10.3920/BM2018.0016DOI Listing
June 2019
7 Reads

Oral administration of heat-killed SBC8803 elevates the ratio of acyl/des-acyl ghrelin in blood and increases short-term food intake.

Benef Microbes 2019 Jul 13;10(6):671-677. Epub 2019 Jun 13.

Frontier Laboratories for Value Creation, Sapporo Holdings Ltd., 10 Okatome, Yaizu, Shizuoka 425-0013, Japan.

It is known that gastrointestinal microbiota, probiotics and heat-killed microbes can regulate intestinal immunity; however, their effect on the secretion of gastrointestinal hormones is unclear. The secretion of gastrointestinal hormones can be mediated by the elevation of intracellular Ca concentration, suggesting that these hormones may act through common mechanisms. We have previously shown that heat-killed SBC8803 (hk-SBC8803) induced the secretion of serotonin and elevated intracellular Ca concentration in serotonin-producing RIN-14B cells, suggesting that hk-SBC8803 could potentially cause the same effect on other gastrointestinal hormones, including hunger hormone ghrelin. Read More

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http://dx.doi.org/10.3920/BM2018.0091DOI Listing
July 2019
1 Read

Gut microbiota development of preterm infants hospitalised in intensive care units.

Benef Microbes 2019 Jul 9;10(6):641-651. Epub 2019 Jun 9.

Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan.

Gut microbiome development affects infant health and postnatal physiology. The gut microbe assemblages of preterm infants have been reported to be different from that of healthy term infants. However, the patterns of ecosystem development and inter-individual differences remain poorly understood. Read More

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http://dx.doi.org/10.3920/BM2019.0003DOI Listing
July 2019
18 Reads