582 results match your criteria Beneficial microbes[Journal]


Lactobacillus casei CRL 431 improves endothelial and platelet functionality in a pneumococcal infection model.

Authors:
C Haro M Medina

Benef Microbes 2019 Apr 9:1-10. Epub 2019 Apr 9.

3 Instituto de Microbiología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), Ayacucho 451, CP 4000, San Miguel de Tucumán, Tucumán, Argentina.

Streptococcus pneumoniae is able to activate coagulation and induce platelet aggregation, both of which are typical responses to systemic inflammation. The interactions between inflammation and coagulation and between soluble adhesion molecules and endothelial cells are important in the pathogenesis of an unbalanced haemostatic system. Therefore, an exaggerated and/or insufficiently controlled haemostatic activity may appreciably contribute to the severity of the disease. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2018.0099
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http://dx.doi.org/10.3920/BM2018.0099DOI Listing
April 2019
2 Reads

Preventative effects of selenium-enriched Bifidobacterium longum on irinotecan-induced small intestinal mucositis in mice.

Benef Microbes 2019 Apr 9:1-10. Epub 2019 Apr 9.

2 State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, China P.R.

Intestinal mucositis is a frequent side effect in cancer patients who are treated with chemotherapy. There are no effective treatment strategies to date. To find a novel way to alleviate mucositis, the effects of selenium-enriched Bifidobacterium longum (Se-B. Read More

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http://dx.doi.org/10.3920/BM2018.0096DOI Listing

Effect of Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 on the productivity, reproductive aging, and physiological characteristics of hens and roosters.

Benef Microbes 2019 Apr 9:1-18. Epub 2019 Apr 9.

1 Laboratory of Experimental Mutagenesis, Academy of Biology and Biotechnology, Southern Federal University, Stachki av. 194/1, Rostov-on-Don 344090, Russia.

The study aims at investigating the effect of preparations of two bacilli strains on laying hens and roosters. Preparations were based on the strains Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895. Several groups of roosters and hens received a preparation based on either strain, or a mixture of both, from the first day to the last day of poultry in production. Read More

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http://dx.doi.org/10.3920/BM2018.0149DOI Listing

Anti-genotoxic and anti-mutagenic activity of Escherichia coli Nissle 1917 as assessed by in vitro tests.

Benef Microbes 2019 Apr 8:1-14. Epub 2019 Apr 8.

1 Ardeypharm GmbH, Loerfeldstraβe 20, 58313 Herdecke, Germany.

Anti-genotoxic or anti-mutagenic activity has been described for a number of Gram-positive probiotic bacterial species. Here we present evidence that Gram-negative Escherichia coli Nissle 1917 (EcN) also displays anti-genotoxic/anti-mutagenic activity, as assessed in vitro by the Comet Assay and the Ames Test, respectively. This activity was demonstrated by use of the mutagens 4-nitroquinoline-1-oxide (NQO), hydrogen peroxide (HO) and benzo(a) pyrene (B[a]P). Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2018.0113
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http://dx.doi.org/10.3920/BM2018.0113DOI Listing
April 2019
3 Reads

Lactobacillus fermentum and Lactobacillus plantarum increased gut microbiota diversity and functionality, and mitigated Enterobacteriaceae, in a mouse model.

Benef Microbes 2019 Apr 8:1-12. Epub 2019 Apr 8.

1 Department of Food Technology, Engineering and Nutrition, Lund University, 221 00 Lund, Sweden.

Probiotics should bring 'balance' to the intestinal microbiota by stimulating beneficial bacteria, whilst mitigating adverse ones. Balance can also be interpreted as high alpha-diversity. Contrary, Escherichia coli is often regarded as an adverse component of the resident intestinal microbiota. Read More

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http://dx.doi.org/10.3920/BM2018.0074DOI Listing

Blueberries as an additive to increase the survival of Lactobacillus johnsonii N6.2 to lyophilisation.

Benef Microbes 2019 Apr 1:1-10. Epub 2019 Apr 1.

1 Department of Microbiology and Cell Science, Genetics Institute, Institute for Food and Agricultural Sciences, University of Florida, Gainesville, FL 32610, USA.

Effective cultivation methods, total cost, and biomass preservation are key factors that have a significant impact on the commercialisation and effectiveness of probiotics, such as Lactobacillus. Sugar polymers, milk and whey proteins have been suggested as good additives for industrial preparations. Alternative compounds, such as phytophenols, are a more attractive option, given their potential benefits to human health. Read More

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http://dx.doi.org/10.3920/BM2018.0144DOI Listing

Effects of Lactobacillus reuteri as an adjunct to the treatment of periodontitis in smokers: randomised clinical trial.

Benef Microbes 2019 Apr 1:1-10. Epub 2019 Apr 1.

3 Latin American Institute of Dental Research and Education (ILAPEO), Department of Periodontology, Curitiba, Paraná, Brazil.

The aim of this randomised clinical trial was to evaluate the effect of Lactobacillus reuteri in chewable tablets as an adjunct to non-surgical periodontal treatment of chronic periodontitis in smoking patients. 34 patient smokers were selected and randomly divided into two groups. The SRP group (n=17) received scaling and root planing (SRP) in one session and a placebo; the PRO group (n=17) received SRP in one session and 2 probiotic tablets 2× per day, for 21 days. Read More

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http://dx.doi.org/10.3920/BM2018.0150DOI Listing
April 2019
1.500 Impact Factor

Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study.

Benef Microbes 2019 Mar 18:1-20. Epub 2019 Mar 18.

1 School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia.

Probiotics have been reported to exert beneficial effects along the gut-brain axis. This randomised, double-blind and placebo-controlled human study aimed to evaluate such properties of Lactobacillus plantarum DR7 and its accompanying mechanisms in stressed adults. One hundred and eleven (n=111; DR7 n=56, placebo n=55) stressed adults were recruited based on moderate stress levels using the PSS-10 questionnaire. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2018.0135
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http://dx.doi.org/10.3920/BM2018.0135DOI Listing
March 2019
15 Reads

Lactobacillus paracasei PS23 reduced early-life stress abnormalities in maternal separation mouse model.

Benef Microbes 2019 Mar 18:1-12. Epub 2019 Mar 18.

4 Microbiome Research Center, National Yang-Ming University, No.155, Sec.2, Linong Street, Beitou Dist., Taipei 11221, Taiwan ROC.

Maternal separation (MS) has been developed as a model for inducing stress and depression in studies using rodents. The concept of the gut-brain axis suggests that gut health is essential for brain health. Here, we present the effects of administration of a probiotic, Lactobacillus paracasei PS23 (PS23), to MS mice against psychological traits including anxiety and depression. Read More

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http://dx.doi.org/10.3920/BM2018.0077DOI Listing

Potential vaginal probiotics: safety, tolerability and preliminary effectiveness.

Benef Microbes 2019 Mar 18:1-10. Epub 2019 Mar 18.

1 Competence Centre on Health Technologies, Tiigi 61B, Tartu 50410, Estonia.

Vaginal discharge is one of the common reasons for gynaecologist consultation, as bacterial vaginosis and candidiasis are the main causes of discharge. These patients frequently experience numerous problems due to recurrent infections, side effects and drug resistance therefore alternative drugs are needed. Our primary aim was to evaluate safety and tolerability of the potentially probiotic Lactobacillus crispatus strains in volunteer women considering themselves healthy. Read More

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http://dx.doi.org/10.3920/BM2016.0123DOI Listing
March 2019
1 Read

Widespread use of Lactobacillus OppA, a surface located protein, as an adhesin that recognises epithelial cell surface glycosaminoglycans.

Benef Microbes 2019 Mar 18:1-10. Epub 2019 Mar 18.

1 Área de Microbiología, Universidad de Oviedo, Julián Clavería 6, 33006 Oviedo, Spain.

Specific adherence is the first requisite that a microorganism has to fulfil to become established onto a mucosal surface. It was previously shown that the OppA surface protein of Lactobacillus salivarius Lv72 bound HeLa cell cultures through interaction with glycosaminoglycans (GAGs). To determine whether this is a peculiarity of that strain or whether it can be extended to other lactobacilli, 12 strains, belonging to six species, were confronted with HeLa-cell cultures in the presence of soluble GAGs. Read More

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http://dx.doi.org/10.3920/BM2018.0128DOI Listing

Deciphering the influence of paraimmunobiotic bifidobacteria on the innate antiviral immune response of bovine intestinal epitheliocytes by transcriptomic analysis.

Benef Microbes 2019 Mar 10;10(2):199-209. Epub 2018 Dec 10.

3 Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 984-0051, Japan.

Previously, we reported that the non-viable immunomodulatory Bifidobacterium infantis MCC12 and Bifidobacterium breve MCC1274 strains (paraimmunobiotic bifidobacteria) were able to increase the protection against rotavirus infection in bovine intestinal epithelial (BIE) cells. In order to gain insight into the influence of paraimmunobiotic bifidobacteria on the innate antiviral immune response of BIE cells, their effect on the transcriptomic response triggered by Toll-like receptor 3 (TLR3) activation was investigated. By using microarray technology and qPCR analysis, we obtained a global overview of the immune genes involved in the innate antiviral immune response in BIE cells. Read More

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http://dx.doi.org/10.3920/BM2018.0024DOI Listing
March 2019
1 Read

Mechanisms and immunomodulatory properties of pre- and probiotics.

Benef Microbes 2019 Mar 4:1-12. Epub 2019 Mar 4.

3 TNO Zeist, Department Risk Analysis for Products in Development (RAPID), Utrechtseweg 48, 3704 HE Zeist, the Netherlands.

The human body is exposed to many xenobiotic, potentially harmful compounds. The intestinal immune system is crucial in protecting the human body from these substances. Moreover, many microorganisms, residing in the gastrointestinal tract, play an important role in modulating immune responses. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2018.0066
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http://dx.doi.org/10.3920/BM2018.0066DOI Listing
March 2019
7 Reads

Effects of functional pasta ingredients on different gut microbiota as revealed by TIM-2 in vitro model of the proximal colon.

Benef Microbes 2019 Mar 4:1-14. Epub 2019 Mar 4.

3 Maastricht University - campus Venlo, Centre for Healthy Eating and Food Innovation, NUTRIM School of Nutrition and Translational Research in Metabolism, St. Jansweg 20, 5928 RC Venlo, the Netherlands.

Diet-related modulation of gut microbiota and its metabolic activity represents an intriguing research context, particularly in the case of disorders related to imbalances in gut microbial communities. We here explored the effects of Bacillus coagulans GBI-30, 6086 (BC30), β-glucans, and innovative whole-grain pastas, with or without these functional ingredients, on gut microbiota from three groups of children, presenting different susceptibility to type 1 diabetes, by using the well-controlled TNO in vitro model of the proximal colon (TIM-2). Short- and branched-chain fatty acids production and microbiota composition were assessed by means of gas chromatography and 16S rRNA gene profiling, respectively. Read More

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http://dx.doi.org/10.3920/BM2018.0088DOI Listing

In vitro neuroprotective activities of two distinct probiotic consortia.

Benef Microbes 2019 Mar 4:1-12. Epub 2019 Mar 4.

1 Cultech Limited, Unit 2 Christchurch Road, Baglan Industrial Park, Port Talbot, SA12 7BZ, United Kingdom.

Neurodegeneration has been linked to changes in the gut microbiota and this study compares the neuroprotective capability of two bacterial consortia, known as Lab4 and Lab4b, using the established SH-SY5Y neuronal cell model. Firstly, varying total antioxidant capacities (TAC) were identified in the intact cells from each consortia and their secreted metabolites, referred to as conditioned media (CM). 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Crystal Violet (CV) assays of cell viability revealed that Lab4 CM and Lab4b CM could induce similar levels of proliferation in SH-SY5Y cells and, despite divergent TAC, possessed a comparable ability to protect undifferentiated and retinoic acid-differentiated cells from the cytotoxic actions of rotenone and undifferentiated cells from the cytotoxic actions of 1-methyl-4-phenylpyridinium iodide (MPP+). Read More

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http://dx.doi.org/10.3920/BM2018.0105DOI Listing
March 2019
1 Read

Prebiotic supplementation over a cold season and during antibiotic treatment specifically modulates the gut microbiota composition of 3-6 year-old children.

Benef Microbes 2019 Feb 19:1-12. Epub 2019 Feb 19.

6 Beneo-Institute, c/o Beneo GmbH, Wormser Straβe 11, 67283 Obrigheim, Germany.

Supplementing kindergarten children during a cold season with a prebiotic inulin-type fructans product with shorter and longer fructan chains has been shown to reduce febrile episodes requiring medical attention and to lower the incidence of sinusitis. These beneficial effects may be connected to the specific modulation of children's gut microbiota. By applying quantitative and qualitative microbiota analysis this study aimed at characterising the gut microbiota composition and at exploring effects of prebiotic intervention on the gut microbiota during a 24-weeks intervention and during antibiotic treatment in healthy children. Read More

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http://dx.doi.org/10.3920/BM2018.0116DOI Listing
February 2019
3 Reads

Bacteriocins of Gram-positive bacteria having activity spectra extending beyond closely-related species.

Benef Microbes 2019 Feb 18:1-14. Epub 2019 Feb 18.

2 BLIS Technologies Ltd, 81 Glasgow Street, South Dunedin 9012, New Zealand.

Bacteriocins are bacterially-produced antimicrobial peptides that have killing activity principally against other relatively closely-related bacteria. Some bacteriocins of the lactic acid bacteria (LAB) have for many years been extensively applied in food biopreservation. However, especially during the last decade, a number of reports have appeared about unanticipated extensions to the generally rather narrow anti-bacterial activity spectrum of some of the LAB bacteriocins and novel applications have been proposed for bacteriocins ranging from controlling the growth of an increasingly-heterogeneous variety of pathogens, including Gram-negative multidrug resistant bacteria, viruses, yeasts, and in particular, difficult to control Mycobacterium spp. Read More

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http://dx.doi.org/10.3920/BM2018.0126DOI Listing
February 2019
1 Read

Bacteriocin production and adhesion properties as mechanisms for the anti-listerial activity of Lactobacillus plantarum 423 and Enterococcus mundtii ST4SA.

Benef Microbes 2019 Feb 18:1-22. Epub 2019 Feb 18.

1 Department of Microbiology, University of Stellenbosch, Matieland, Stellenbosch 7600, South Africa.

Probiotics play an important role in maintaining a healthy and stable intestinal microbiota, primarily by preventing infection. Probiotic lactic acid bacteria (LAB) are known to be inhibitory to many bacterial enteric pathogens, including antibiotic-resistant strains. Whilst the positive role that probiotics have on human physiology, specifically in the treatment or prevention of specific infectious diseases of the gastro-intestinal tract (GIT) is known, the precise mechanistic basis of these effects remains a major research goal. Read More

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http://dx.doi.org/10.3920/BM2018.0141DOI Listing
February 2019
1 Read

Prebiotic oligosaccharides in early life alter gut microbiome development in male mice while supporting influenza vaccination responses.

Benef Microbes 2019 Feb 18:1-14. Epub 2019 Feb 18.

2 Danone Nutricia Research, Department of Immunology / Microbiology, Uppsalalaan 12, 3584 CT Utrecht, the Netherlands.

Beneficial modulation of the gut microbiota is an attractive therapeutic approach to improve the efficacy of vaccine-induced immunity. In this study, mice were supplemented with the prebiotic milk oligosaccharide 2'-fucosyllactose (2'FL) as well as a complex mixture of immune modulatory prebiotic short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS) from different stages in early life. Adult mice were vaccinated with trivalent influenza vaccine (TIV) and both development of the gut microbiota and antibody-mediated vaccine responses were followed over time. Read More

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http://dx.doi.org/10.3920/BM2018.0098DOI Listing
February 2019
1 Read

Foreword - nearly 10 years of Beneficial Microbes.

Authors:
Koen Venema

Benef Microbes 2019 Feb;10(1):1-3

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http://dx.doi.org/10.3920/BM2019.x001DOI Listing
February 2019

Spores of Bacillus coagulans GBI-30, 6086 show high germination, survival and enzyme activity in a dynamic, computer-controlled in vitro model of the gastrointestinal tract.

Benef Microbes 2019 Feb 29;10(1):77-87. Epub 2019 Jan 29.

2 Maastricht University - campus Venlo, Centre for Healthy Eating & Food Innovations, St. Jansweg 20, 5928 RC Venlo, the Netherlands.

The aim of this study was to assess the germination, survival and metabolic activity of the probiotic Bacillus coagulans GBI-30, 6086 [GanedenBC] (BC30) in a dynamic, computer controlled in vitro model of the gastrointestinal (GI) tract, simulating human adults. Experiments were performed in the presence of a meal to maximise germination, due to the presence of germination-triggers. Both an upper GI tract (stomach and small intestine; TIM-1) and a colon model (TIM-2) were used, where material exiting TIM-1 was added to TIM-2. Read More

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http://dx.doi.org/10.3920/BM2018.0037DOI Listing
February 2019

Dysbiosis in early sepsis can be modulated by a multispecies probiotic: a randomised controlled pilot trial.

Benef Microbes 2019 Jan 29:1-14. Epub 2019 Jan 29.

2 Center for Biomarker Research in Medicine (CBmed), Stiftingtalstrasse 5, 8010 Graz, Austria.

The gut is hypothesised to play an important role in the development and progression of sepsis. It is however unknown whether the gut microbiome and the gut barrier function is already altered early in sepsis development and whether it is possible to modulate the microbiome in early sepsis. Therefore, a randomised, double blind, placebo-controlled pilot study to examine the alterations of the microbiome and the gut barrier in early sepsis and the influence of a concomitant probiotic intervention on dysbiosis at this early stage of the disease was conducted. Read More

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http://dx.doi.org/10.3920/BM2018.0067DOI Listing
January 2019
1 Read

Lactobacillus plantarum IS-10506 supplementation increases faecal sIgA and immune response in children younger than two years.

Benef Microbes 2019 Jan 29:1-8. Epub 2019 Jan 29.

3 Food Technology Department, Faculty of Engineering, Bina Nusantara University, Jakarta 11480, Indonesia.

The immature intestinal immune system in young children develops as it comes into contact with dietary and microbial antigens in the gut. Intestinal microbiota plays a significant role in host defence mechanisms as shown by inflammatory responses towards potential pathogens. We investigated the probiotic function of Lactobacillus plantarum IS-10506 of ' dadih'origin in modulating immune response in young children. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2017.0178
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http://dx.doi.org/10.3920/BM2017.0178DOI Listing
January 2019
12 Reads

Lactobacillus rhamnosus GG can protect malnourished children.

Benef Microbes 2019 Jan 14:1-8. Epub 2019 Jan 14.

3 Department of Pediatrics, Regional Training and Research Hospital, 25280 Erzurum, Turkey.

Malnutrition affects virtually all organ systems, and malnourished children are more prone to infections. These children have dysbiosis, but probiotics can restore the disrupted gut microbiome. We investigated the protective effects of Lactobacillus rhamnosus GG in malnourished children in terms of incidence of infection, and anthropometric and metabolic parameters. Read More

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http://dx.doi.org/10.3920/BM2018.0071DOI Listing
January 2019
1 Read

Effect of Lactobacillus delbrueckii LAB4 on hepatic and pancreatic sympathetic nerve activity and blood glucose levels in rats.

Benef Microbes 2019 Jan 14:1-8. Epub 2019 Jan 14.

1 ANBAS Corporation, 4-12-10 Toyosaki, Kita-ku, Osaka 531-0072, Japan.

Various lactobacilli have been suggested to exert beneficial effects in humans. In this study, we examined the effects of intraduodenal (ID) administration of heat-killed Lactobacillus delbrueckii LAB4 (LAB4) on activities of efferent sympathetic nerves innervating the liver and pancreas. Consequently, it was observed that ID administration of LAB4 significantly reduced either the efferent hepatic sympathetic nerve activity (hepatic-SNA) or pancreatic sympathetic nerve activity (pancreatic-SNA) in urethane-anaesthetised rats. Read More

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http://dx.doi.org/10.3920/BM2018.0083DOI Listing
January 2019

Bacillus clausii UBBC-07 reduces severity of diarrhoea in children under 5 years of age: a double blind placebo controlled study.

Benef Microbes 2019 Mar 14;10(2):149-154. Epub 2019 Jan 14.

3 K.R.M. hospital and Research Centre, Department of Pediatrics, Room No 01 3/92-93,Vijayant Khand Lucknow, Uttar Pradesh, India.

Acute diarrhoea is one of the leading causes of mortality in infants and young children. Evidence suggests that probiotics can reduce diarrhoea duration. As the effects of probiotics are strain specific, the effect of Bacillus clausii UBBC-07, a safe probiotic strain in the treatment of acute diarrhoea in children was studied. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2018.0094
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http://dx.doi.org/10.3920/BM2018.0094DOI Listing
March 2019
2 Reads

Maternal antibiotic prophylaxis affects Bifidobacterium spp. counts in the human milk, during the first week after delivery.

Benef Microbes 2019 Mar 21;10(2):155-163. Epub 2018 Dec 21.

1 School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 580, São Paulo, SP, 05508-000, Brazil.

Human milk is an important source of microorganisms for infant gut colonisation. Although the maternal antibiotic prophylaxis is an important strategy to prevent maternal/neonatal sepsis, it has to be investigated how it may affect the human milk microbiota, especially the genus Bifidobacterium, which has been associated to health benefits. Here, we investigated the impact of the maternal antibiotic prophylaxis on the human milk Bifidobacterium spp. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2018.0046
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http://dx.doi.org/10.3920/BM2018.0046DOI Listing
March 2019
2 Reads

Impact of probiotics on development and behaviour in Drosophila melanogaster - a potential in vivo model to assess probiotics.

Benef Microbes 2019 Mar 21;10(2):179-188. Epub 2018 Dec 21.

1 Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Paseo Río Linares s/n, 33300 Villaviciosa, Asturias, Spain.

In vitro models are frequently used in probiotic research. However, such models often fail to predict in vivo functionality and efficacy. This fact complicates the screening process for selecting the most suitable strains, prior to accomplish expensive animal studies and clinical intervention trials. Read More

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http://dx.doi.org/10.3920/BM2018.0012DOI Listing

Eczema-protective probiotic alters infant gut microbiome functional capacity but not composition: sub-sample analysis from a RCT.

Benef Microbes 2019 Feb 21;10(1):5-17. Epub 2018 Dec 21.

2 Microbiome Otago, University of Otago, 720 Cumberland St., 9016 Dunedin, New Zealand.

Probiotic Lactobacillus rhamnosus HN001 given in early life has been shown to reduce infant eczema risk, but its effect on gut microbiota development has not been quantitatively and functionally examined. The aim of this study was to investigate the impact of early life probiotic exposure on the composition and functional capacity of infant gut microbiota from birth to 2 years considering the effects of age, delivery mode, antibiotics, pets and eczema. We performed shotgun metagenomic sequencing analysis of 650 infant faecal samples, collected at birth, 3, 12, and 24 months, as part of a randomised, controlled, 3-arm trial assessing the effect of L. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2017.0191
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http://dx.doi.org/10.3920/BM2017.0191DOI Listing
February 2019
7 Reads

Effects of long-term administration of Lactobacillus reuteri DSM-17938 on circulating levels of 5-HT and BDNF in adults with functional constipation.

Benef Microbes 2019 Mar 21;10(2):137-147. Epub 2018 Dec 21.

1 Laboratory of Nutritional Pathophysiology, National Institute of Digestive Diseases I.R.C.C.S. 'Saverio de Bellis', Via Turi 27, 70013 Castellana Grotte, Bari, Italy.

Accumulated evidence shows that some probiotic strains ameliorate functional constipation (FC) via the modulation of specific gastrointestinal peptide pathways. The aims of this study were to investigate: (1) the effects of long-term administration of Lactobacillus reuteri (LR) DSM 17938 on the serum levels of serotonin (5-HT) and brain-derived neurotrophic factor (BDNF); (2) the possible link between 5-HT, BDNF, and specific constipation-related symptoms; (3) whether genetic variability at the 5-HTT gene-linked polymorphic region (5-HTTLPR) and BDNF Val66Met loci could be associated with serum 5-HT and BDNF variations. LR DSM 17938 was administered to 56 FC patients for 105 days in a randomised, double-blind manner. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2018.0050
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http://dx.doi.org/10.3920/BM2018.0050DOI Listing
March 2019
7 Reads

Persistent infection by Salmonella enterica servovar Typhimurium: are synbiotics a therapeutic option? - a case report.

Benef Microbes 2019 Mar 21;10(2):211-217. Epub 2018 Dec 21.

5 Bifodan A/S, Bogbinderivej 6, 3390 Hundested, Denmark.

Little is known about the prevalence of persistent human infections by nontyphoidal Salmonella (NTS). Recently published study results indicate that a small fraction (at least 2.2%) of NTS-infected patients continue to shed Salmonella for an extended period of time (up to years). Read More

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http://dx.doi.org/10.3920/BM2018.0080DOI Listing
March 2019
1 Read

Microencapsulated feruloyl esterase-producing lactobacilli ameliorate lipid profile and glycaemia in high fat diet-induced obese mice.

Benef Microbes 2019 Mar 10;10(2):189-198. Epub 2018 Dec 10.

1 Centro de Referencia para Lactobacilos (CERELA)-CONICET, Chacabuco 145, T4000ILC, San Miguel de Tucumán, Tucumán, Argentina.

The effect of oral administration of spray-dried microcapsules of feruloyl esterase (FE) producing Lactobacillus fermentum CRL1446 (Lf) and Lactobacillus johnsonii CRL1231 (Lj) on high fat diet-induced obese mice was investigated to evaluate whether these strains could be used as a biotherapeutic for obesity. Swiss albino mice were divided into a normal diet fed group receiving empty microcapsules (control), a high fat diet plus empty microcapsules (HFD group), HFD plus microcapsules with Lf (HFD-Lf group) and HDF plus microcapsules with Lj (HFD-Lj group). Microcapsules containing Lf or Lj at a dose of ~10 cells/day/mouse were given orally for 7 weeks. Read More

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http://dx.doi.org/10.3920/BM2018.0025DOI Listing
March 2019
2 Reads

Mice co-administrated with partially hydrolysed whey proteins and prebiotic fibre mixtures show allergen-specific tolerance and a modulated gut microbiota.

Benef Microbes 2019 Mar 10;10(2):165-178. Epub 2018 Dec 10.

1 Nutricia Research, Uppsalalaan 12, 3584 CT Utrecht, the Netherlands.

Non-breastfed infants at-risk of allergy are recommended to use a hydrolysed formula before the age of 6 months. The addition of prebiotics to this formula may reduce the allergy development in these infants, but clinical evidence is still inconclusive. This study evaluates (1) whether the exposure duration to different prebiotics alongside a partially hydrolysed whey protein (pHP) influences its' effectiveness to prevent allergy development and (2) whether the gut microbiota plays a role in this process. Read More

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http://dx.doi.org/10.3920/BM2018.0001DOI Listing

Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial.

Benef Microbes 2019 Feb 10;10(1):19-26. Epub 2018 Dec 10.

3 Institute for Maternal and Child Health-IRCCS "Burlo Garofolo, Department of Medical Science, University of Trieste, via dell`Istria 65/1, 34100 Trieste, Italy.

Bacterial vaginosis (BV) is the most common cause of vaginal discomfort in women. It is characterised by abnormal vaginal microbiota with a depletion of lactobacilli and predominance of anaerobic microorganisms, mainly Gardnerella vaginalis and Atopobium vaginae. Although antibiotics represent an effective therapeutic option in the short-term, recurrent infections still remain a serious problem. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2018.0075
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http://dx.doi.org/10.3920/BM2018.0075DOI Listing
February 2019
3 Reads

Probiotic Bifidobacterium lactis, anti-oxidant vitamin E/C and anti-inflammatory dha attenuate lung inflammation due to pm2.5 exposure in mice.

Benef Microbes 2019 Feb 10;10(1):69-75. Epub 2018 Dec 10.

1 Gastroenterology Unit, IRCCS Casa Sollievo della Sofferenza Hospital, viale dei Cappuccini n. 1, 71013 San Giovanni Rotondo (FG), Italy.

The incidence of asthma and allergic diseases of the airways is constantly increasing, both in the industrialised and developing countries, due to harmful and excessive quantities of air pollution. Although some studies have shown an effect of dietary supplementation of specific nutrients (especially with anti-oxidant and anti-inflammatory properties) in reducing airways inflammatory response, the results are not yet conclusive and the science is still at its infancy. Our hypothesis is that combining such nutrients could provide more benefits than using them alone. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2018.0060
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http://dx.doi.org/10.3920/BM2018.0060DOI Listing
February 2019
1 Read

Bifidobacterium infantis M-63 improves mental health in victims with irritable bowel syndrome developed after a major flood disaster.

Benef Microbes 2019 Mar 10;10(2):111-120. Epub 2018 Dec 10.

1 School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Kelantan, Malaysia.

Individuals in a community who developed irritable bowel syndrome (IBS) after major floods have significant mental health impairment. We aimed to determine if Bifidobacterium infantis M-63 was effective in improving symptoms, psychology and quality of life measures in flood-affected individuals with IBS and if the improvement was mediated by gut microbiota changes. Design was non-randomised, open-label, controlled before-and-after. Read More

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http://dx.doi.org/10.3920/BM2018.0008DOI Listing
March 2019
1 Read

Probiotic or synbiotic alters the gut microbiota and metabolism in a randomised controlled trial of weight management in overweight adults.

Benef Microbes 2019 Mar 10;10(2):121-135. Epub 2018 Dec 10.

5 Global Health and Nutrition Science, DuPont Nutrition & Health, Sokeritehtaantie 20, 02460 Kantvik, Finland.

The gut microbiota contributes to host energy metabolism, and altered gut microbiota has been associated with obesity-related metabolic disorders. We previously reported that a probiotic alone or together with a prebiotic controls body fat mass in healthy overweight or obese individuals in a randomised, double-blind, placebo controlled clinical study (ClinicalTrials.gov NCT01978691). Read More

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http://dx.doi.org/10.3920/BM2018.0028DOI Listing

Multiple sclerosis and faecal microbiome transplantation: are you going to eat that?

Benef Microbes 2019 Feb 10;10(1):27-32. Epub 2018 Dec 10.

1 University of Western Ontario, 339 Windermere Rd, London, ON N6A 5A5, Canada.

Gut microbiome interaction goes beyond commensal function as vitamin production or support nutrients digestion. It also interplays with the host immune system and may be related to the development of immune-mediated diseases. Multiple sclerosis patients have dysbiosis compared to healthy individuals. Read More

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http://dx.doi.org/10.3920/BM2018.0029DOI Listing
February 2019

Bifidobacterium longum IM55 and Lactobacillus plantarum IM76 alleviate allergic rhinitis in mice by restoring Th2/Treg imbalance and gut microbiota disturbance.

Benef Microbes 2019 Feb 22;10(1):55-67. Epub 2018 Nov 22.

2 Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.

This study aimed to examine whether probiotics, which suppressed the differentiation of splenic T cells into type 2 helper T (Th2) cells and induced into regulatory T cells in vitro, alleviate allergic rhinitis (AR) and gut microbiota disturbance. We isolated Bifidobacterium longum IM55 and Lactobacillus plantarum IM76 from human faecal microbiota and kimchi, respectively, and examined their effects on ovalbumin (OVA)-induced AR and gut microbiota disturbance in mice. Treatment with IM55, IM76, or their probiotic mixture (PM) significantly reduced OVA-induced allergic nasal symptoms and blood immunoglobulin E (IgE) levels in mice. Read More

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http://dx.doi.org/10.3920/BM2017.0146DOI Listing
February 2019
8 Reads

Regulatory T cells and Toll-like receptor 2 and 4 mRNA expression in infants with colic treated with Lactobacillus reuteri DSM17938.

Benef Microbes 2018 Nov 8:1-10. Epub 2018 Nov 8.

2 Dipartimento delle Scienze di Sanità Pubblica e Pediatriche, Università degli Studi di Torino, Scuola di Medicina, Piazza Polonia, 94, 10126 Turin, Italy.

Regulatory T cells induce immune homeostasis and the expression of Toll like receptors (TLRs); subsequent inflammatory cytokine release may be involved. Recent studies have shown a microbial imbalance in the gut of colicky infants (with a prevalence of gram-negative bacteria, such as Escherichia coli), and accumulating evidence has shown the efficacy of a probiotic (Lactobacillus reuteri) in breastfed subjects, but the underlying mechanism remains undefined. The study enrolled 59 infants younger than 60 days, of whom 34 subjects had colic and 25 were healthy controls. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2017.0194
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http://dx.doi.org/10.3920/BM2017.0194DOI Listing
November 2018
17 Reads

Protective effect of Lactobacillus reuteri KUB-AC5 against Salmonella Enteritidis challenge in chickens.

Benef Microbes 2019 Feb 8;10(1):43-54. Epub 2018 Nov 8.

1 Department of Biotechnology, Faculty of Agro-Industry, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.

Poultry is an important high-quality food and protein source for humans. However, chicken is considered a primary source of foodborne diseases, especially Salmonella Enteritidis infection. Reducing Salmonella contamination in live poultry will thus lower the risk to consumers. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2018.0034
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http://dx.doi.org/10.3920/BM2018.0034DOI Listing
February 2019
13 Reads

Two alkaline motifs in the Lactobacillus salivarius Lv72 OppA surface are important to its adhesin function.

Benef Microbes 2019 Feb 8;10(1):101-109. Epub 2018 Nov 8.

1 Área de Microbiología, Universidad de Oviedo, Julián Clavería 6, 33006 Oviedo, Spain.

Glycosaminoglycans are involved in the attachment of Lactobacillus salivarius Lv72, a strain of vaginal origin, to HeLa cell cultures, indicating that they play a fundamental role in the attachment of mutualistic bacteria to the epithelium lining cavities where the normal microbiota thrives. The bacterial OppA protein has been proposed as an adhesin involved in this adherence since, once purified, it significantly interferes with attachment of the lactobacilli to HeLa cell cultures. In this article, the role of OppA is confirmed through the determination of its location at the cell surface and its ability to promote Lactobacillus casei and Lactococcus lactis adherence to eukaryotic cell cultures upon cloning and expression of oppA in these bacteria. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2018.0052
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http://dx.doi.org/10.3920/BM2018.0052DOI Listing
February 2019
7 Reads

Comment on 'Gut microbiota characterisation in obese patients before and after bariatric surgery'.

Benef Microbes 2018 Nov 8:1-2. Epub 2018 Nov 8.

2 Department of Advanced Translational Microbiology, Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Via dell'Istria 65/1, 34137 Trieste, Italy.

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http://dx.doi.org/10.3920/BM2018.x004DOI Listing
November 2018

Lactobacillus paracasei K5 displays adhesion, anti-proliferative activity and apoptotic effects in human colon cancer cells.

Benef Microbes 2018 Oct 24:1-10. Epub 2018 Oct 24.

1 Department of Molecular Biology and Genetics, Faculty of Health Sciences, Democritus University of Thrace, Alexandroupolis 68100, Greece.

Lactobacillus paracasei K5 is a lactic acid bacteria (LAB) strain, isolated recently from feta-type cheese. Its probiotic potential has been demonstrated in a series of established in vitro tests. Moreover, incorporation of L. Read More

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http://dx.doi.org/10.3920/BM2017.0183DOI Listing
October 2018

Bioactive factors secreted by Bifidobacterium breve B-3 enhance barrier function in human intestinal Caco-2 cells.

Benef Microbes 2019 Feb 24;10(1):89-100. Epub 2018 Oct 24.

1 Department of Biofunctional Science and Technology, Graduate School of Biosphere Science, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima 739-8528, Japan.

Intestinal barrier function is closely related to intestinal health and diseases. Recent studies demonstrate that some probiotic and commensal bacteria secrete metabolites that are capable of affecting the intestinal functions. The present study examined an enhancing effect of bioactive factors secreted by Bifidobacterium breve strain B-3 on the intestinal tight junction (TJ) barrier integrity in human intestinal Caco-2 cells. Read More

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http://dx.doi.org/10.3920/BM2018.0062DOI Listing
February 2019
1 Read

Beneficial effects of Saccharomyces cerevisiae RC016 in weaned piglets: in vivo and ex vivo analysis.

Benef Microbes 2019 Feb 2;10(1):33-42. Epub 2018 Oct 2.

1 Universidad Nacional de Río Cuarto, Ruta 36 km.601, 5800 Río Cuarto, Córdoba, Argentina.

Probiotics represents an alternative to replace antibiotics as growth promoters in animal feed and are able to control enteric bacterial diseases and to improve gut immunity. Saccharomyces cerevisiae RC016 showed previously inhibition/coagregation of pathogens) and mycotoxins adsorbent ability (aflatoxin B, ochratoxin A and zearalenone). The aim of this work was to evaluate beneficial properties of S. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2018.0023
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http://dx.doi.org/10.3920/BM2018.0023DOI Listing
February 2019
3 Reads

The role of adjuvant probiotics to attenuate intestinal inflammatory responses due to cancer treatments.

Benef Microbes 2018 Sep 20:1-18. Epub 2018 Sep 20.

1 The University of Sydney, School of Medicine, Faculty of Medicine and Health, NSW 2006, Australia.

Chemotherapy and radiotherapy treatment regimens for gastrointestinal, peritoneal and pelvic tumours can disrupt the intestinal microbiome and intestinal epithelia. Such disturbances can provoke symptoms such as diarrhoea, nausea and vomiting. Chemotherapy and radiotherapy induced gastrointestinal toxicity aggravating intestinal microbiome dysbiosis is postulated to adversely alter the intestinal microbiome, with a consequent induced pro-inflammatory effect that disrupts the intestinal microbiome-epithelia-mucosal immunity axis. Read More

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http://dx.doi.org/10.3920/BM2017.0172DOI Listing
September 2018
30 Reads

Systemic immune response of gnotobiotic mice infected with porcine circovirus type 2 after administration of Lactobacillus reuteri L26 Biocenol™.

Benef Microbes 2018 Sep 20:1-12. Epub 2018 Sep 20.

1 Department of Pathological Anatomy and Pathological Physiology, University of Veterinary Medicine and Pharmacy, Komenského 73, 04181 Košice, Slovakia.

In our previous study we confirmed an antiviral activity of probiotic Lactobacillus reuteri L26 which was mediated by stimulation of local intestinal immunity. The aim of this paper was to evaluate the influence of L. reuteri L26 on the systemic immune response in gnotobiotic mice infected with porcine circovirus type 2 (PCV2). Read More

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http://dx.doi.org/10.3920/BM2017.0147DOI Listing
September 2018

Functional modulation of caecal fermentation and microbiota in rat by feeding bean husk as a dietary fibre supplement.

Benef Microbes 2018 Sep 13:1-12. Epub 2018 Sep 13.

1 Graduate School of Agriculture, Hokkaido University, Kita 9 Nishi 9, Sapporo, Japan.

A feeding study using rats was conducted to evaluate the utility of lablab bean husk and soya bean husk as sources of potential prebiotic fibre. Twenty 5-week-old Sprague Dawley rats were divided into 4 groups and fed one of the following diets for 3 weeks: purified diet (AIN93 G) containing 5% cellulose (CEL), or the same diet in which cellulose was replaced by corn starch (STA), lablab bean husk (LBH), or soya bean husk (SBH). Rats were sacrificed at 8 weeks of age and caecal digesta were collected. Read More

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http://dx.doi.org/10.3920/BM2017.0174DOI Listing
September 2018
1 Read

Mind the gut: probiotics in paediatric neurogastroenterology.

Benef Microbes 2018 Sep 10:1-16. Epub 2018 Sep 10.

6 KidZ Health Castle, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.

The gut-brain axis has recently emerged as a key modulator of human health and the intestinal microbiome has a well-recognised pivotal role in this strong connection. The aim of this narrative review is to update and summarise the effect and clinical applicability of probiotics in paediatric neurogastroenterology. The Cochrane Database and PubMed were searched using keywords relating to different subtypes of functional gastrointestinal disorders (FGIDs) and their symptoms, those relating to the CNS and related neurological or behavioural dysfunction as well as 'probiotic' OR 'probiotics'. Read More

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https://www.wageningenacademic.com/doi/10.3920/BM2018.0013
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http://dx.doi.org/10.3920/BM2018.0013DOI Listing
September 2018
41 Reads