9,969 results match your criteria Belgian Journal Of Zoology[Journal]


The resolution process and the timing of settlement of medical malpractice claims.

Health Econ Policy Law 2019 Apr 17:1-21. Epub 2019 Apr 17.

Faculty of Business Economics,Hasselt University,3500 Hasselt,Belgium.

We draw on uniquely detailed micro-level data from a Belgian professional medical liability insurer to examine how different procedural and legal events that take place during the unfolding of a medical malpractice claim influence the timing of its settlement. Utilizing the competing risks regression framework, we find that settlement hazard is all else equal statistically significantly positively associated with the completion of those procedural and legal events that most effectively reveal factual information about the underlying medical malpractice case. Consistent with theory, settlement hazard is either unassociated or even negatively associated with the completion of other procedural and legal events. Read More

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http://dx.doi.org/10.1017/S1744133119000185DOI Listing

Trends in Belgian cause-specific mortality by migrant origin between the 1990s and the 2000s.

BMC Public Health 2019 Apr 16;19(1):410. Epub 2019 Apr 16.

Interface Demography, Department of Social Research, Faculty of Economic and Social Sciences & Solvay Business School, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium.

Background: Belgium has a large migrant community that is increasingly ageing. As migrants may have faced environmental and social exposures before, during and after migration, they may have experienced an accelerated epidemiological transition. Studying mortality differentials between the migrant and native population may therefore allow for a better understanding of the aetiology of diseases. Read More

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http://dx.doi.org/10.1186/s12889-019-6724-2DOI Listing

Long-term clinical effectiveness of ustekinumab in patients with Crohn's disease who failed biological therapies: a national cohort study.

J Crohns Colitis 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.

Background: Ustekinumab (UST) was recently approved in Europe for the treatment of moderate to severe Crohn's disease (CD). Long-term real-world data are currently scarce in CD patients previously exposed to several biologics.

Methods: This is an observational, national, retrospective multicenter study. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz080DOI Listing

Habitual food consumption of the Belgian population in 2014-2015 and adherence to food-based dietary guidelines.

Arch Public Health 2019 5;77:14. Epub 2019 Apr 5.

Sciensano, Department of Epidemiology and public health, Unit Lifestyle and chronic diseases, Brussels, Belgium.

Background: Between 2014 and 2015 a second National Food Consumption Survey was conducted in Belgium in order to evaluate the habitual food consumption in the general Belgian population and to compare it with food-based dietary guidelines (FBDG) and results of the 2004 Food Consumption Survey.

Methods: A representative sample of the Belgian population was randomly selected from the National Population Register following a multistage stratified sampling procedure. Information on dietary intake was collected from 3146 subjects between 3 and 64 year old through two non-consecutive 24-hour dietary recalls using GloboDiet®. Read More

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http://dx.doi.org/10.1186/s13690-019-0343-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449930PMC
April 2019
2 Reads

MeshMonk: Open-source large-scale intensive 3D phenotyping.

Sci Rep 2019 Apr 15;9(1):6085. Epub 2019 Apr 15.

Department of Electrical Engineering, ESAT/PSI, KU Leuven, Leuven, Belgium.

Dense surface registration, commonly used in computer science, could aid the biological sciences in accurate and comprehensive quantification of biological phenotypes. However, few toolboxes exist that are openly available, non-expert friendly, and validated in a way relevant to biologists. Here, we report a customizable toolbox for reproducible high-throughput dense phenotyping of 3D images, specifically geared towards biological use. Read More

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http://www.nature.com/articles/s41598-019-42533-y
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http://dx.doi.org/10.1038/s41598-019-42533-yDOI Listing
April 2019
1 Read

Food Supplements to Mitigate Detrimental Effects of Pelvic Radiotherapy.

Microorganisms 2019 Apr 3;7(4). Epub 2019 Apr 3.

Interdisciplinary Biosciences Group, Belgian Nuclear Research Centre (SCK•CEN), Boeretang 200, 2400 Mol, Belgium.

Pelvic radiotherapy has been frequently reported to cause acute and late onset gastrointestinal (GI) toxicities associated with significant morbidity and mortality. Although the underlying mechanisms of pelvic radiation-induced GI toxicity are poorly understood, they are known to involve a complex interplay between all cell types comprising the intestinal wall. Furthermore, increasing evidence states that the human gut microbiome plays a role in the development of radiation-induced health damaging effects. Read More

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https://www.mdpi.com/2076-2607/7/4/97
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http://dx.doi.org/10.3390/microorganisms7040097DOI Listing
April 2019
1 Read

Growth of Endothelial Cells in Space and in Simulated Microgravity - a Comparison on the Secretory Level.

Cell Physiol Biochem 2019 ;52(5):1039-1060

Clinic for Plastic, Aesthetic and Hand Surgery, Otto von Guericke University Magdeburg, Magdeburg, Germany.

Background/aims: Endothelial cells exposed to the Random Positioning Machine (RPM) reveal three different phenotypes. They grow as a two-dimensional monolayer and form three-dimensional (3D) structures such as spheroids and tubular constructs. As part of the ESA-SPHEROIDS project we want to understand how endothelial cells (ECs) react and adapt to long-term microgravity. Read More

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https://www.cellphysiolbiochem.com/Articles/000071/
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http://dx.doi.org/10.33594/000000071DOI Listing
January 2019
2 Reads

Ethnic and Socioeconomic Segregation in Belgium: A Multiscalar Approach Using Individualised Neighbourhoods.

Eur J Popul 2018 May 6;34(2):225-250. Epub 2018 Apr 6.

2Netherlands Interdisciplinary Demographic Institute (NIDI)/KNAW/University of Groningen, Lange Houtstraat 19, 2511 CV The Hague, The Netherlands.

Segregation may have profound effects when it is paired with an accumulation of inequalities. This is namely the case when ethnic and socioeconomic segregation overlap. Few studies in Europe have, however, addressed the relationship between ethnic and socioeconomic segregation in a comprehensive manner. Read More

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http://dx.doi.org/10.1007/s10680-018-9480-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241109PMC

First aid glucose administration routes for symptomatic hypoglycaemia.

Cochrane Database Syst Rev 2019 Apr 11;4:CD013283. Epub 2019 Apr 11.

Centre for Evidence-Based Practice (CEBaP), Belgian Red Cross, Motstraat 42, Mechelen, Belgium, 2800.

Background: Hypoglycaemia is a common occurrence in people with diabetes but can also result from an imbalance in glucose homeostasis in the absence of diabetes. The best enteral route for glucose administration for suspected hypoglycaemia in a first aid situation is unknown.

Objectives: To assess the effects of first aid glucose administration by any route appropriate for use by first-aid providers (buccal, sublingual, oral, rectal) for symptomatic hypoglycaemia. Read More

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http://doi.wiley.com/10.1002/14651858.CD013283.pub2
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http://dx.doi.org/10.1002/14651858.CD013283.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459163PMC
April 2019
4 Reads

Fungi and Mycotoxins in Space-A Review.

Astrobiology 2019 Apr 11. Epub 2019 Apr 11.

1 Laboratory of Food Analysis, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

Fungi are not only present on Earth but colonize spacecraft and space stations as well. This review provides an extensive overview of the large and diverse group of fungal species that have been found in space, as well as those corresponding detection methods used and the existing and potential future prevention and control strategies. Many of the identified fungal species in space, such as Aspergillus flavus and Alternaria sp. Read More

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http://dx.doi.org/10.1089/ast.2018.1854DOI Listing

Is there a risk of transfusion-transmissible infections after percutaneous needle treatments in blood donors? A systematic review and meta-analysis.

Vox Sang 2019 Apr 10. Epub 2019 Apr 10.

Centre for Evidence-Based Practice, Belgian Red Cross, Mechelen, Belgium.

Background And Objectives: The donor medical questionnaire identifies a blood donor's history of known blood safety risks. Current Australian, Canadian, European and USA legislation temporarily defers blood donors who received different percutaneous needle treatments (i.e. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/vox.12780
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http://dx.doi.org/10.1111/vox.12780DOI Listing
April 2019
1 Read

Earlier Initiation of Antiretroviral Treatment Coincides With an Initial Control of the HIV-1 Sub-Subtype F1 Outbreak Among Men-Having-Sex-With-Men in Flanders, Belgium.

Front Microbiol 2019 26;10:613. Epub 2019 Mar 26.

Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

Human immunodeficiency virus type 1 (HIV-1) non-B subtype infections occurred in Belgium since the 1980s, mainly amongst migrants and heterosexuals, whereas subtype B predominated in men-having-sex-with-men (MSM). In the last decade, the diagnosis of F1 sub-subtype in particular has increased substantially, which prompted us to perform a detailed reconstruction of its epidemiological history. To this purpose, the Belgian AIDS Reference Laboratories collected HIV-1 sequences from all sub-subtype F1-infected patients for whom genotypic drug resistance testing was requested as part of routine clinical follow-up. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443750PMC
March 2019
1 Read
3.941 Impact Factor

Obsessions Across Two Cultures: A Comparison of Belgian and Turkish Non-clinical Samples.

Front Psychol 2019 26;10:657. Epub 2019 Mar 26.

Center for Social and Cultural Psychology, Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium.

There is a growing interest in the role of culture in Obsessive-Compulsive Disorder, yet cultural studies to date have suffered from methodological limitations and lack a clear theoretical framework. In the current study, we adopted a rigorous methodological approach, and a clear cultural psychological framework. We compared the structure and frequency of obsessions in non-clinical samples ( = 706) from Belgium, a Western culture, and Turkey, a non-Western cultural context. Read More

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https://www.frontiersin.org/article/10.3389/fpsyg.2019.00657
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http://dx.doi.org/10.3389/fpsyg.2019.00657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443853PMC
March 2019
2 Reads

Martian dust storm impact on atmospheric HO and D/H observed by ExoMars Trace Gas Orbiter.

Nature 2019 Apr 10. Epub 2019 Apr 10.

Space Research Institute (IKI), Russian Academy of Sciences (RAS), Moscow, Russia.

Global dust storms on Mars are rare but can affect the Martian atmosphere for several months. They can cause changes in atmospheric dynamics and inflation of the atmosphere, primarily owing to solar heating of the dust. In turn, changes in atmospheric dynamics can affect the distribution of atmospheric water vapour, with potential implications for the atmospheric photochemistry and climate on Mars. Read More

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http://dx.doi.org/10.1038/s41586-019-1097-3DOI Listing

No detection of methane on Mars from early ExoMars Trace Gas Orbiter observations.

Nature 2019 Apr 10. Epub 2019 Apr 10.

European Space Research and Technology Centre (ESTEC), ESA, Noordwijk, The Netherlands.

The detection of methane on Mars has been interpreted as indicating that geochemical or biotic activities could persist on Mars today. A number of different measurements of methane show evidence of transient, locally elevated methane concentrations and seasonal variations in background methane concentrations. These measurements, however, are difficult to reconcile with our current understanding of the chemistry and physics of the Martian atmosphere, which-given methane's lifetime of several centuries-predicts an even, well mixed distribution of methane. Read More

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http://www.nature.com/articles/s41586-019-1096-4
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http://dx.doi.org/10.1038/s41586-019-1096-4DOI Listing
April 2019
1 Read

Insufficient evidence for a role of SERPINF1 in otosclerosis.

Mol Genet Genomics 2019 Apr 9. Epub 2019 Apr 9.

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Universiteitsplein 1, Wilrijk, 2610, Antwerp, Belgium.

Otosclerosis is a common form of hearing loss (HL) due to abnormal remodeling of the otic capsule. The genetic causes of otosclerosis remain largely unidentified. Only mutations in a single gene, SERPINF1, were previously published in patients with familial otosclerosis. Read More

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http://dx.doi.org/10.1007/s00438-019-01558-8DOI Listing
April 2019
1 Read

Nutrient, pigment, suspended matter and turbidity measurements in the Belgian part of the North Sea.

Sci Data 2019 Apr 9;6(1):22. Epub 2019 Apr 9.

Flanders Marine Institute (VLIZ), Wandelaarkaai 7, 8400, Oostende, Belgium.

Through regular sampling surveys, the Flanders Marine Institute is generating long term data series for the Belgian coastal water and sand bank systems, a designated site in the Long Term Ecological Research (LTER) network. The data series is built on sampling activities initiated in 2002, but gradually upgraded and extended in the framework of the LifeWatch marine observatory and the Integrated Carbon Observation System (ICOS) participation. Nine nearshore stations are sampled monthly, with additional seasonal sampling of eight offshore stations. Read More

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http://dx.doi.org/10.1038/s41597-019-0032-7DOI Listing

Knowledge of orthodontic treatment approach of traumatized teeth by a group of Belgian general dentists, pediatric dentists and orthodontists.

Dent Traumatol 2019 Apr 9. Epub 2019 Apr 9.

KU Leuven Department of Oral Health Sciences, Population studies in Oral health, Leuven, Belgium.

Background/aim: Traumatized teeth are more susceptible to complications during orthodontic tooth movement. The aim of this study was to explore current practices among Belgian dental practitioners regarding orthodontic treatment of children with a history of dental trauma.

Material And Methods: A questionnaire survey was organized among general dentists, pediatric dentists and orthodontists in Flanders (Belgium). Read More

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http://dx.doi.org/10.1111/edt.12474DOI Listing

Respective influence of current alcohol consumption and duration of heavy drinking on brain morphological alterations in alcohol use disorder.

Addict Biol 2019 Apr 9:e12751. Epub 2019 Apr 9.

Institute of Neuroscience, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.

Numerous studies have explored the morphological differences of the brain between subjects with alcohol use disorder (AUD) and control subjects, but very few have investigated the impact of the duration of alcohol use disorder (DAD) and current level of alcohol consumption (CAC) within AUD subjects using magnetic resonance imaging (MRI). We compared the morphological MRI of 44 controls and 66 AUD subjects, recruited at the end of a detoxification program. Additional analyses within the AUD group determined which specific alterations were respectively associated with DAD and CAC using: (1) Bonferroni-corrected multivariable linear regressions to explore the DAD/CAC impact on brain volumes and (2) a general linear model (GLM module of FreeSurfer's Qdec) and Monte Carlo simulation to correct for multiple comparisons (P < 0. Read More

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http://dx.doi.org/10.1111/adb.12751DOI Listing
April 2019
1 Read

Berberis sawfly contains toxic peptides not only at larval stage.

Naturwissenschaften 2019 Apr 8;106(5-6):14. Epub 2019 Apr 8.

Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain, Place Louis Pasteur 1, 1348, Louvain-la-Neuve, Belgium.

Livestock can die from grazing in areas where larvae of certain Argidae or Pergidae species containing toxic peptides occur in mass. However, it remains unknown whether other stages also contain these compounds. Here, single specimens of larvae, prepupae, and adults of Arge berberidis, plus samples of its cocoons and larval feces, were analyzed by liquid chromatography-tandem mass spectrometry. Read More

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http://dx.doi.org/10.1007/s00114-019-1613-1DOI Listing

Supportive care in cancer patients: a constantly evolving field.

Curr Opin Oncol 2019 Apr 4. Epub 2019 Apr 4.

Department of Medical Oncology, Academisch Ziekenhuis, Vrije Universiteit Brussel, Brussels, Belgium.

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http://dx.doi.org/10.1097/CCO.0000000000000542DOI Listing

A validated computational framework to evaluate the stiffness of 3D printed ankle foot orthoses.

Comput Methods Biomech Biomed Engin 2019 Apr 8:1-8. Epub 2019 Apr 8.

a Department of Electronics and Information Systems , Institute Biomedical Technology (IBiTech) - bioMMeda, Ghent University , Gent , Belgium.

The purpose of this study was to create and validate a standardized framework for the evaluation of the ankle stiffness of two designs of 3D printed ankle foot orthoses (AFOs). The creation of four finite element (FE) models allowed patient-specific quantification of the stiffness and stress distribution over their specific range of motion during the second rocker of the gait. Validation was performed by comparing the model outputs with the results obtained from a dedicated experimental setup, which showed an overall good agreement with a maximum relative error of 10. Read More

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https://www.tandfonline.com/doi/full/10.1080/10255842.2019.1
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http://dx.doi.org/10.1080/10255842.2019.1601712DOI Listing
April 2019
4 Reads

Association between dietary nutrient intake and sarcopenia in the SarcoPhAge study.

Aging Clin Exp Res 2019 Apr 6. Epub 2019 Apr 6.

Department of Public Health, Epidemiology and Health Economics, University of Liège, Avenue Hippocrate 13, CHU Bât B23, 4000, Liège, Belgium.

Background: It has been suggested that a balanced nutritional intake may be useful in preventing or even reversing sarcopenia.

Aim: To describe cross-sectional associations between dietary nutrient intake and sarcopenia.

Methods: Subjects recruited from the SarcoPhAge study population completed a food frequency questionnaire. Read More

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http://dx.doi.org/10.1007/s40520-019-01186-7DOI Listing

Occupational Exposure to Metals in Shooting Ranges: A Biomonitoring Study.

Saf Health Work 2019 Mar 26;10(1):87-94. Epub 2018 May 26.

Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.

Background: Lead (Pb) exposure in shooting ranges has been reduced by various measures such as jacketed ammunition and lead-free primers. Nevertheless, this may lead to exposure to other metals, potentially resulting in adverse health effects.

Methods: In a cross-sectional study, 35 subjects from seven different shooting ranges were studied: four shooting instructors, 10 police officers, 15 Special Forces, and six maintenance staff members. Read More

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http://dx.doi.org/10.1016/j.shaw.2018.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428968PMC

Testing compliance to WHO guidelines for physical activity in Flanders insights from time-use diaries.

Arch Public Health 2019 20;77:16. Epub 2019 Mar 20.

1Research group TOR, Department of Sociology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.

Background: Regular physical activity decreases the risk for numerous non-communicable diseases. The World Health Organization has suggested physical activity (PA) guidelines that, based on previous research, would provide health benefits to those who comply. The first guideline for health benefits suggests 150 min of moderate PA or equivalent per week. Read More

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http://dx.doi.org/10.1186/s13690-019-0341-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429766PMC

Identification of fungal isolates by MALDI-TOF mass spectrometry in veterinary practice: validation of a web application.

J Vet Diagn Invest 2019 Apr 4:1040638719835577. Epub 2019 Apr 4.

Belgian Coordinated Collections of Microorganisms (BCCM/IHEM) Fungal Collection, Mycology and Aerobiology, Sciensano, Brussels, Belgium (Becker, Stubbe, Hendrickx).

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has emerged as a reliable method to identify fungal isolates. The success of this approach relies on the availability of exhaustive databases, but the latter were built with a focus on human pathogens. We assessed a large in-house database of reference spectra and a dedicated web application for their suitability for use in veterinary laboratories. Read More

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http://dx.doi.org/10.1177/1040638719835577DOI Listing

Impact of LEDGIN treatment during virus production on residual HIV-1 transcription.

Retrovirology 2019 Apr 2;16(1). Epub 2019 Apr 2.

Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49, Box 1023, 3000, Leuven, Flanders, Belgium.

Background: Persistence of latent, replication-competent provirus is the main impediment towards the cure of HIV infection. One of the critical questions concerning HIV latency is the role of integration site selection in HIV expression. Inhibition of the interaction between HIV integrase and its chromatin tethering cofactor LEDGF/p75 is known to reduce integration and to retarget residual provirus to regions resistant to reactivation. Read More

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http://dx.doi.org/10.1186/s12977-019-0472-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444612PMC
April 2019
2 Reads

Concerns following the rapid implementation of first-line screening for aneuploidies by cell-free DNA analysis in the Belgian health care system.

Ultrasound Obstet Gynecol 2019 Apr 2. Epub 2019 Apr 2.

Department of Obstetrics and Gynecology, University Hospital Brugmann, Université Libre de Bruxelles, Brussels, Belgium.

The high performance of cell-free DNA (cfDNA) analysis of maternal blood in screening for trisomies 21, 18 and 13 in high- and low-risk pregnancies in now well established. In May 2017, our Minister of Public Health announced the reimbursement of non-invasive prenatal testing (NIPT) as a first-line screening tool for all pregnant women in Belgium. Patients have to pay 8. Read More

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http://dx.doi.org/10.1002/uog.20280DOI Listing

The EMPCAN study: protocol of a population-based cohort study on the evolution of the socio-economic position of workers with cancer.

Arch Public Health 2019 20;77:15. Epub 2019 Mar 20.

2Research Centre for Environmental and Occupational Health, School of Public Health, Université Libre de Bruxelles, Brussels, Belgium.

Background: The improvements in cancer control led to an increase in the number of cancer survivors, notably, in the working age population (16-64 years). There is a strong need to assess and understand their reintegration on the labour market, which underlines and ensures their social integration and quality of life. The objectives of the EMPCAN study is therefore to measure the scale of return-to-work after cancer and to identify the determining factors, allowing for the implementation of an adequate socio-professional support. Read More

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http://dx.doi.org/10.1186/s13690-019-0337-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427850PMC
March 2019
1 Read

Knowledge of nurses and nursing assistants about pressure ulcer prevention: A survey in 16 Belgian hospitals using the PUKAT 2.0 tool.

J Tissue Viability 2019 Mar 27. Epub 2019 Mar 27.

Skin Integrity Research Group (SKINT), University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium; School of Nursing and Midwifery, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; School of Health Sciences, Örebro University, Sweden. Electronic address:

Background: Pressure ulcers have a high impact on patients and their families. Profound and up-to-date knowledge among nurses is important given the effect on attitudes and preventative behaviour. To gain insight into educational needs and priorities, regular knowledge assessments are needed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0965206X183012
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http://dx.doi.org/10.1016/j.jtv.2019.03.002DOI Listing
March 2019
8 Reads

Cost-effectiveness and screening performance of ECG handheld machine in a population screening programme: The Belgian Heart Rhythm Week screening programme.

Eur J Prev Cardiol 2019 Apr 1:2047487319839184. Epub 2019 Apr 1.

10 Cliniques du Sud-Luxembourg, Arlon, Belgium.

Aims: Overall, 40% of patients with atrial fibrillation are asymptomatic. The usefulness and cost-effectiveness of atrial fibrillation screening programmes are debated. We evaluated whether an atrial fibrillation screening programme with a handheld electrocardiogram (ECG) machine in a population-wide cohort has a high screening yield and is cost-effective. Read More

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http://dx.doi.org/10.1177/2047487319839184DOI Listing

Modulation of Iberian Ribbed Newt Complement Component C3 by Stressors Similar to those Encountered during a Stay Onboard the International Space Station.

Int J Mol Sci 2019 Mar 29;20(7). Epub 2019 Mar 29.

Stress Immunity Pathogens Laboratory, EA 7300, Faculty of Medicine, Université de Lorraine, 9 avenue de la Foret de Haye, F-54500 Vandœuvre-lès-Nancy, France.

The complement system plays an important role in inflammation, innate and acquired immunity, as well as homeostasis. Despite these functions, the effects of spaceflight conditions on the complement system have not yet been intensively studied. Consequently, we investigated the effects of five types of chronic stressors, similar to those encountered during a stay onboard the International Space Station, on C3 expression in larvae of the urodele amphibian . Read More

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http://dx.doi.org/10.3390/ijms20071579DOI Listing
March 2019
4 Reads

Bayesian sequential integration within a preclinical pharmacokinetic and pharmacodynamic modeling framework: Lessons learned.

Pharm Stat 2019 Apr 1. Epub 2019 Apr 1.

Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium.

The present manuscript aims to discuss the implications of sequential knowledge integration of small preclinical trials in a Bayesian pharmacokinetic and pharmacodynamic (PK-PD) framework. While, at first sight, a Bayesian PK-PD framework seems to be a natural framework to allow for sequential knowledge integration, the scope of this paper is to highlight some often-overlooked challenges while at the same time providing some guidances in the many and overwhelming choices that need to be made. Challenges as well as opportunities will be discussed that are related to the impact of (1) the prior specification, (2) the choice of random effects, (3) the type of sequential integration method. Read More

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http://dx.doi.org/10.1002/pst.1941DOI Listing

Donor insemination disclosure in social networks: heterosexual couples' experiences.

Cult Health Sex 2019 Apr 1:1-15. Epub 2019 Apr 1.

b Bioethics Institute Ghent, Ghent University , Ghent , Belgium.

The way in which heterosexual couples manage information about infertility and donor insemination within their social networks has not yet been explored in-depth. This study focuses on how parents and aspiring parents manage information about infertility and donor insemination within their social networks. Fifteen Belgian couples were interviewed as part of a parenthood research project. Read More

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http://dx.doi.org/10.1080/13691058.2019.1589578DOI Listing

Four notable additions to the South African echinoid fauna (Echinodermata, Echinoidea).

Zookeys 2019 18;831:71-80. Epub 2019 Mar 18.

Marine Research Institute, Department of Biological Sciences, University of Cape Town, Rondebosch 7700, South Africa University of Cape Town Rondebosch South Africa.

Although a comprehensive guide to the South African echinoid fauna was published as recently as 2017, four notable additions to the fauna have emerged since that time and are reported on here. The first South African records for (Thomson, 1872), (Linnaeus, 1758), L. Agassiz, in Agassiz and Desor 1846, and Troschel, 1869 are presented. Read More

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http://dx.doi.org/10.3897/zookeys.831.31381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433812PMC

Current Management of pT3b Prostate Cancer After Robot-assisted Laparoscopic Prostatectomy.

Eur Urol Oncol 2019 Feb 27;2(1):110-117. Epub 2018 May 27.

Department of Urology, Ghent University Hospital, Ghent, Belgium.

Background: Robot-assisted radical prostatectomy (RALP) in high-risk and locally advanced prostate cancer (PCa) is gaining increasing traction. The optimal use of additional treatments for PCa with seminal vesicle invasion (pT3b) after RALP remains ill explored.

Objective: To evaluate the management of pT3b PCa after RALP in current clinical practice. Read More

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http://dx.doi.org/10.1016/j.euo.2018.05.005DOI Listing
February 2019
2 Reads

Lymphoepithelial carcinoma of the accessory parotid gland.

Br J Oral Maxillofac Surg 2019 Mar 27. Epub 2019 Mar 27.

Division of Maxillofacial Surgery, Department of Pediatric Surgery, Hospital Sant Joan de Deu (Barcelona Children's Hospital), Esplugues de Llobregat, Barcelona, Spain.

Lymphoepithelial carcinoma of the accessory parotid gland is rare, and to our knowledge, only two cases have previously been reported. It has an association with the Epstein-Barr virus and is usually seen in Asians and Greenland Eskimos. We report a case of lymphoepithelial carcinoma of the left accessory parotid gland in a 59-year-old European man who had been raised in the Belgian Congo. Read More

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http://dx.doi.org/10.1016/j.bjoms.2018.09.017DOI Listing

Shifting national surveillance of Shigella infections toward geno-serotyping by the development of a tailored Luminex assay and NGS workflow.

Microbiologyopen 2019 Mar 28:e00807. Epub 2019 Mar 28.

National Reference Centre of Salmonella and Shigella, Brussels, Belgium.

The phylogenetically closely related Shigella species and enteroinvasive Escherichia coli (EIEC) are responsible for millions of episodes of bacterial dysenteriae worldwide. Given its distinct epidemiology and public health relevance, only Shigellae are subject to mandatory reporting and follow-up by public health authorities. However, many clinical laboratories struggle to differentiate non-EIEC, EIEC, and Shigella in their current workflows, leading to inaccuracies in surveillance and rising numbers of misidentified E. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mbo3.807
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http://dx.doi.org/10.1002/mbo3.807DOI Listing
March 2019
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Accuracy of malaria diagnosis by clinical laboratories in Belgium.

Malar J 2019 Mar 28;18(1):104. Epub 2019 Mar 28.

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Background: The Belgian Reference Laboratory for Plasmodium offers a free-of-charge reference testing of malaria-positive or doubtful samples to clinical laboratories.

Methods: The final malaria diagnosis from the Reference Laboratory (microscopy, rapid diagnostic tests (RDTs) and Plasmodium species-specific PCR) were compared with the final diagnosis from peripheral Belgian laboratories. The Reference Laboratory reports were analysed for all samples submitted between 2013 and 2017. Read More

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http://dx.doi.org/10.1186/s12936-019-2731-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437969PMC

Prevalence of multidrug-resistant organisms in nursing homes in Belgium in 2015.

PLoS One 2019 28;14(3):e0214327. Epub 2019 Mar 28.

National Reference Centre for antibiotic resistant Gram-negative bacilli, Laboratory of Clinical Microbiology, Centre hospitalier universitaire de Namur, Université catholique de Louvain, Yvoir, Belgium.

Objectives: Following two studies conducted in 2005 and 2011, a third prevalence survey of multidrug-resistant microorganisms (MDRO) was organised in Belgian nursing homes (NHs) using a similar methodology. The aim was to measure the prevalence of carriage of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), extended-spectrum β-lactamase producing Enterobacteriaceae (ESBLE) and carbapenemase-producing Enterobacteriaceae (CPE) in NH residents. Risk factors for MDRO carriage were also explored. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214327PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438666PMC
March 2019
4 Reads

Neonatologists and neonatal nurses have positive attitudes towards perinatal end-of-life decisions, a nationwide survey.

Acta Paediatr 2019 Mar 28. Epub 2019 Mar 28.

End-of-Life Care Research Group, Ghent University & Vrije Universiteit Brussel (VUB), Brussel, Belgium.

Aim: Perinatal death is often preceded by an end-of-life decision (ELD). Disparate hospital policies, complex legal frameworks and ethically difficult cases make attitudes important. This study investigated attitudes of neonatologists and nurses towards perinatal ELDs. Read More

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http://dx.doi.org/10.1111/apa.14797DOI Listing

European Qualitative research project on Patient-preferred outcomes in Early Rheumatoid Arthritis (EQPERA): rationale, design and methods of a multinational, multicentre, multilingual, longitudinal qualitative study.

BMJ Open 2019 Mar 27;9(3):e023606. Epub 2019 Mar 27.

Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre, Maastricht, The Netherlands.

Introduction: Including the patient perspective is important to achieve optimal outcomes in the treatment of rheumatoid arthritis (RA). Ample qualitative studies exist on patient outcomes in RA. A Belgian study recently unravelled what matters most to patients throughout the overwhelming and rapidly evolving early stage of RA. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023606DOI Listing

The arbuscular mycorrhizal symbiosis regulates aquaporins activity and improves root cell water permeability in maize plants subjected to water stress.

Plant Cell Environ 2019 Mar 27. Epub 2019 Mar 27.

Departmento de Microbiología del Suelo y Sistemas Simbióticos, Estación Experimental del Zaidín (CSIC), 18008, Granada, Spain.

Studies have suggested that increased root hydraulic conductivity in mycorrhizal roots could be the result of increased cell-to-cell water flux via aquaporins. This study aimed to elucidate if the key effect of the regulation of maize aquaporins by the arbuscular mycorrhizal (AM) symbiosis is the enhancement of root cell water transport capacity. Thus, water permeability coefficient (P ) and cell hydraulic conductivity (L ) were measured in root protoplast and intact cortex cells of AM and non-AM plants subjected or not to water stress. Read More

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http://dx.doi.org/10.1111/pce.13551DOI Listing

Method validation to assess in vivo cellular and subcellular changes in buccal mucosa cells and saliva following CBCT examinations.

Dentomaxillofac Radiol 2019 Apr 5:20180428. Epub 2019 Apr 5.

2 Belgian Nuclear Research Centre, Radiobiology Unit, SCK•CEN , Mol , Belgium.

Objectives:: Cone-beam CT (CBCT) is a medical imaging technique used in dental medicine. However, there are no conclusive data available indicating that exposure to X-ray doses used by CBCT are harmless. We aim, for the first time, to characterize the potential age-dependent cellular and subcellular effects related to exposure to CBCT imaging. Read More

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http://dx.doi.org/10.1259/dmfr.20180428DOI Listing

Evidence for faster X chromosome evolution in spiders.

Mol Biol Evol 2019 Mar 26. Epub 2019 Mar 26.

Department of Bioscience, Aarhus University, 8000 Aarhus C, Denmark.

In species with chromosomal sex determination, X chromosomes are predicted to evolve faster than autosomes because of positive selection on recessive alleles or weak purifying selection. We investigated X chromosome evolution in Stegodyphus spiders that differ in mating system, sex-ratio, and population dynamics. We assigned scaffolds to X chromosomes and autosomes using a novel method based on flow cytometry of sperm cells and reduced representation sequencing. Read More

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http://dx.doi.org/10.1093/molbev/msz074DOI Listing

Time perception and the experience of agency in meditation and hypnosis.

Psych J 2019 Mar;8(1):36-50

Sackler Centre for Consciousness Science, University of Sussex, Falmer, UK.

Mindfulness meditation and hypnosis are related in opposing ways to awareness of intentions. The cold control theory of hypnosis proposes that hypnotic responding involves the experience of involuntariness while performing an actually intentional action. Hypnosis therefore relies upon inaccurate metacognition about intentional actions and experiences. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pchj.276
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http://dx.doi.org/10.1002/pchj.276DOI Listing
March 2019
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Inspection of Reactor Steel Degradation by Magnetic Adaptive Testing.

Materials (Basel) 2019 Mar 22;12(6). Epub 2019 Mar 22.

SCK•CEN Belgian Nuclear Research Centre, 2400 Mol, Belgium.

Degradation of nuclear pressure vessel steel materials, 15Kh2NMFA type and A508 Cl2 type (definition is given in the text) were investigated by a novel magnetic nondestructive testing method, so-called Magnetic Adaptive Testing (MAT), which is based on systematic measurement and evaluation of minor magnetic hysteresis loops. The measured samples were thermally treated by a special step cooling procedure, which generated structural changes in the material. It was found that this type of degradation can be easily followed by magnetic measurements. Read More

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http://dx.doi.org/10.3390/ma12060963DOI Listing

Invasion windows for a global legume invader are revealed after joint examination of abiotic and biotic filters.

Plant Biol (Stuttg) 2019 Mar 25. Epub 2019 Mar 25.

Disturbance Ecology, BayCEER, University of Bayreuth, Bayreuth, Germany.

Successful alien plant invasion is influenced by both climate change and plant-plant interactions. We estimate the single and interactive effects of competition and extreme weather events on the performance of the global legume invader Lupinus polyphyllus (Lindl.). Read More

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http://dx.doi.org/10.1111/plb.12987DOI Listing

Development and validation of a prognostic model to predict the prognosis of patients who underwent chemotherapy and resection of pancreatic adenocarcinoma: a large international population-based cohort study.

BMC Med 2019 Mar 25;17(1):66. Epub 2019 Mar 25.

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.

Background: Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based study aimed at exploring factors associated with survival in patients with resected TNM stage I-II PaC receiving chemotherapy and at developing and internationally validating a survival-predicting model. Read More

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http://dx.doi.org/10.1186/s12916-019-1304-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432746PMC