Beilstein J Org Chem 2018 26;14:243-252. Epub 2018 Jan 26.
Research Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology (KRICT), 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Korea.
Herein, we describe a novel approach for the practical synthesis of tetrasubstituted thiophenes. The developed method was particularly used for the facile preparation of thienyl heterocycles. The mechanism for this reaction is based on the formation of a sulfur ylide-like intermediate. Read More