2,943 results match your criteria Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences[Journal]


[Independent innovation research of functionally suitable denture digital system].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):390-394

Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Fabrication of conventional complete dentures involves a complex restoration method, requiring significant time and typically involving primary impressions, definitive impressions, jaw relation records, clinic try-in, and complete denture placement, which has been used for nearly a century without change. A novel digital system named Functionally Suitable Denture (FSD) was researched and developed so as to reduce clinical steps, operation difficulties and errors of complete denture restoration. It pioneered a unique diagnostic complete denture aided by computer aided design (CAD) & 3D printing, by which, the functional impression, jaw relation, and try-in (3 steps) were simplified to 1 step, thus the number of visits to the dentist was reduced by 2 times. Read More

View Article

Download full-text PDF

Source

[A rare case of cystadenoma in the small intestine].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):382-384

Department of Oncology, Hebei Hosptical of Traditional Chinese Medicine Affiliated to Hebei University of Traditional Chinese Medicine, Shijiazhuang 050011, China.

In recent years, there have been more and more reports about cystadenoma. Cystadenoma can occur in many parts of the body, and cystadenoma in different parts may show different clinical symptoms, however, some patients with cystadenoma have no symptoms. The vast majority of cystadenomas are benign lesions, but a small number of cystadenomas can be malignant. Read More

View Article

Download full-text PDF

Source

[Lower limb ischemia cured by stimulation electrode implantation assisted with microendoscopic discectomy system: A case report].

Authors:
Y L Qian S Xu H Y Liu

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):378-381

Department of Spinal Surgery, Peking University People's Hospital, Beijing 100044, China.

A 58-year-old male patient diagnosed with thromboangiitis obliterans (Fontaine stage IV) was recently treated with microendoscope discectomy system-assisted spinal cord stimulation electrode implantation and cured by department of vascular surgery combined with department of spinal surgery at Peking University People's Hospital. The patient suffered from cold injury to the right foot 14 years ago, which was cold, painful, numb, and then the toe was ulcerated and gangrene. Only the right foot small toe was left. Read More

View Article

Download full-text PDF

Source

[Kaposi sarcoma combined with severe ulcerative colitis: A case report and literature review].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):373-377

Department of Dermatology, Peking University Third Hospital, Beijing 100191, China.

Kaposi's sarcoma (KS) is an unusual vascular tumor associated with human herpesvirus-8 (HHV-8) infection, which is common in immunosuppressors. Although extremely rare, iatrogenic (drug-related) KS can occur in human immunodeficiency virus (HIV)-negative patients under immunosuppressive therapy. We report a 64-year-old male diagnosed with ulcerative colitis for 1 year. Read More

View Article

Download full-text PDF

Source

[A novel tray for recording maxillomandibular relationship of edentulous patients based on dimensional surveying of complete dentures].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):368-372

Department of Prosthodontics, Center for Digital Dentistry, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To measure the dimensional data of complete dentures and to design a novel tray for recording maxillomandibular relationship of edentulous patients.

Methods: For the measurement, 100 pairs of complete dentures from the clinic were surveyed for the following parameters: a1, the distance between the middle fossa of the upper left and right first molars; a2, the anterior-posterior distance between the middle fossa of the upper first molars and the incisal edge; a3, the width of the upper denture; a4, the anterior-posterior length of the upper denture; a5, the height from the mesio-lingual cusp of the right upper first molar to the saddle surface; a5, the height from the central fossa of the right lower first molar to the saddle surface; a6, the height from the notch of the upper lip frenulum to the upper central incisor edge; a7, the least thickness of the labial saddle base in the upper central incisor region. Based on the data, the trays with different sizes were designed and fabricated, and the key parameters were: b1, the distance between the foramina of screw posts, b2, the anterior-posterior distance between the foramina of the screw posts and the incisal edge; b3, the width of the tray; b4, the anterior-posterior length of the tray; b5, the height of the posterior platform with the screw nut; b5, the height of the screw post; b6, the height of the anterior tray handle; b7, the thickness of the anterior tray handle. Read More

View Article

Download full-text PDF

Source

[Effect of convection enhanced delivery on the microstructure of brain extracellular space in aged rats].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):362-367

Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China.

Objective: To compare the changes of extracellular space (ECS) structure and local drug distribution in adult brain and aged brain at different drug delivery rates in minimally invasive treatment of encephalopathy by convection enhanced delivery (CED) via ECS pathway.

Methods: Thirty-six SD male rats were divided into adult rats group (2-8 months, n=18) and aged rats group (18-24 months, n=18) according to the age of the month. According to the drug rates (0. Read More

View Article

Download full-text PDF

Source

[Clinicopathological features and prognosis of colorectal stromal tumor].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):353-361

Department of Internal Medicine, Tianjin University Hospital, Tianjin 300072, China.

Objective: The incidence of colorectal stromal tumor is low among digestive tract tumors, therefore the literatures about clinicopathological features and prognosis of colorectal stromal tumor are few at home and abroad. In this study, we performed survival analyses for colorectal stromal tumor. The nomogram made by prognostic factors provided basis for evaluation of prognosis. Read More

View Article

Download full-text PDF

Source

[Effect of concentrated growth factors combined with guided tissue regeneration in treatment of classII furcation involvements of mandibular molars].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):346-352

First Clinical Division, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100034, China.

Objective: Tissues loss due to periodontal disease is typically treated by a variety of regenerative treatment modalities, including bone grafts, guided tissue regeneration (GTR) and growth factors, to reform the supporting tissues of teeth. Concentrated growth factors (CGF) are produced by centrifuging blood samples at alternating and controlled speeds using a special centrifuge. The purpose of this study was to evaluate whether GTR could improve the effect of CGF combined with bone graft in the treatment of classII furcations of mandibular molars. Read More

View Article

Download full-text PDF

Source

[Gingival thickness assessment of gingival recession teeth].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):339-345

Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.

Objective: To evaluate the gingival thickness and gingival biotype of gingival recession teeth of Chinese population.

Methods: A total of 112 non-molar teeth with gingival recession in 34 patients were included. Direct measurement, cone-beam computerized tomography (CBCT) measurement and periodontal probe method were used to evaluate gingival thickness and biotype. Read More

View Article

Download full-text PDF

Source

[Effect of vertical soft tissue thickness on clinical manifestation of peri-implant tissue in patients with periodontitis].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):332-338

Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To observe and investigate the effect of vertical soft tissue thickness on the peri-implant tissue condition and the prevalence of peri-implant disease in patients with history of periodontitis.

Methods: Among 210 patients who showed initial interest of implant therapy, 92 patients were included in this study and received implant surgery during 2010 and 2015. Sixty-six patients with 66 implants finally came back for T2 evaluation. Read More

View Article

Download full-text PDF

Source

[wareness and knowledge of oral cancer among 1 483 residents in Beijing].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):323-331

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To investigate the oral cancer awareness, its related knowledge among residents in Beijing.

Methods: A questionnaire survey was conducted among Beijing residents (non-medical related personnel) on the knowledge of oral cancer and its prevention and treatment.

Results: A total of 1 483 questionnaires were completed, including 663 males (44. Read More

View Article

Download full-text PDF

Source

[Trends of prevalence of excellent health status and physical fitness among Chinese Han students aged 13 to 18 years from 1985 to 2014].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):317-322

Peking University School of Public Health, The Institute of Child and Adolescent Health of Peking University, Beijing 100191, China.

Objective: To analyze the trends of prevalence of excellent health status and physical fitness among Chinese Han students aged 13 to 18 years from 1985 to 2014.

Methods: In the study, 738 523 students aged 13 to 18 years were extracted from the 1985 to 2014 Chinese National Survey on Students' Constitution and Health. Height, weight, vital capacity and indicators of physical fitness were measured for each student. Read More

View Article

Download full-text PDF

Source

[Effects of temperature and relative humidity on the number of outpatients with chronic obstructive pulmonary disease and their interaction effect in Lanzhou, China].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):308-316

Lanzhou Center for Disease Prevention and Control, Lanzhou 730030, China.

Objective: To understand the relationships of daily average temperature and relative humidity with outpatient visit frequency of patients with chronic obstructive pulmonary disease, and whether temperature and relative humidity have a lag effect.

Methods: The effects of daily average temperature, relative humidity, and their interaction in Lanzhou between January 2013 and December 2017 on the outpatient visit frequency of chronic obstructive pulmonary disease patients were analyzed using Poisson generalized linear regression model combined with distributed lag non-linear model.

Results: There was a non-linear relationship between the daily average temperature and the outpatient visit frequency of chronic obstructive pulmonary disease patients. Read More

View Article

Download full-text PDF

Source

[Analysis of special ehealth service for corona virus disease 2019 (COVID-19) pneumonia].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):302-307

Department of Health Policy and Management, Peking University School of Public Health, Beijing 100191, China.

Objective: To analyze how governments, hospitals and information technology(IT) companies use Internet technology to provide online health services during the early stage of corona virus disease 2019 (COVID-19) epidemic in January 2020 in China, and then provide suggestions and coping strategies for the later stage and post-epidemic time.

Methods: We searched for information on ehealth services related to the outbreak of COVID-19 in China. The sources of information were mainstream search engines such as Baidu and the popular interactive social platforms such as Webchat. Read More

View Article

Download full-text PDF

Source

[Application of multidisciplinary team (MDT) in the treatment of severe trauma].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):298-301

Trauma Center, Peking University People's Hospital, National Center for Trauma Medicine, Beijing 100044, China.

Objective: To explore the effect of multi-disciplinary team (MDT) in general hospitals on severe trauma patients.

Methods: This study reviewed the treatment of patients with severe trauma in trauma center of Peking University People's Hospital from March 2017 to April 2019. The baseline information: the patients' gender, age, injury mechanism, etc. Read More

View Article

Download full-text PDF

Source

[Analysis of risk factors for necrosis of femoral head after internal fixation surgery in young and mid-aged patients with femoral neck fracture].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):290-297

Department of Orthopedics, Peking University Third Hospital, Beijing 100191, China.

Objective: To retrospectively analyze the risk factors of avascular necrosis of femoral head (ANFH) after internal fixation in young and mid-aged adults.

Methods: From January 2007 to December 2017, femoral neck fracture patients (18-60 years old) treated by reduction and internal fixation were retrospectively studied in Peking University Third Hospital. We recorded their gender, age, body mass index (BMI), American Society of Anesthesiology (ASA) grade, reason of injury, fracture side, interval between injury and surgery, location of fracture line, Garden classification, Pauwels classification, reduction method (open or closed), internal fixation and reduction quality. Read More

View Article

Download full-text PDF

Source

[Analysis of anxiety, depression and related factors in patients with chronic lumbocrural pain before minimally invasive surgery].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):285-289

Pain Medicine Department, Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate anxiety and/or depression status of patients with chronic lumbocrural pain, and to further analyze related risk factors of anxiety and/or depression .

Methods: Retrospective analysis of the medical data of patients who suffered from chronic lumbocrural pain caused by lumbar disc herniation and/or lumbar spinal stenosis and received minimally invasive surgery from March 2018 to April 2018. General data (including age, gender, education levels, past history, sleep order and medical insurance), numeric rating scale(NRS), Japanese Orthopedic Association(JOA) back pain scale and hospital anxiety and depression scale(HADS) were collected for analysis. Read More

View Article

Download full-text PDF

Source

[Predictive values of the combination of Friedman stage and sleep oximetry done early after surgery in predicting the treatment outcomes of uvulopalatopharyngoplasty].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):281-284

Department of Otorhinolaryngology Head and Neck Surgery, Peking University First Hospital, Beijing 100034, China.

Objective: To explore the predictive values of the combination of preoperative data, including medical history and physical examination, and results of sleep oximetry performed early after the surgery (one week) in predicting the treatment outcomes of uvulopalatopharyngoplasty (UPPP) in adult patients with obstructive sleep apnea hypopnea syndrome (OSAHS).

Methods: All the patients who were diagnosed with OSAHS, underwent UPPP treatment and had complete follow-up data in our institution between Jan 2013 and May 2016 were enrolled in our study. The pre-operative data of these patients, including age, physical examination, and polysomnography (PSG) data, were all exactly collected for analysis. Read More

View Article

Download full-text PDF

Source

[Diagnosis and treatment of primary intraspinal abscess].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):275-280

Department of Neurosurgery, Peking University Third Hospital, Beijing, 100191, China.

Objective: To summarize the feature and treatment of the primary intraspinal abscess in order to improve the prognosis.

Methods: In the study, 13 cases of primary intraspinal abscess of the recent 20 years were retrospectively analyzed. The history, etiology, pathogen, surgical methods and prognosis were summarized. Read More

View Article

Download full-text PDF

Source

[Effects of chlorogenic acid on glucose tolerance and its curve characteristics in high-fat diet-induced obesity rats].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):269-274

Institute of Sports Medicine, Peking University Third Hospital, Beijing 100191, China.

Objective: To observe the effect of chlorogenic acid (chlorogenic acid, CGA) on the glucose tolerance and its curve characteristics in high fat diet-induced obesity (diet-induced-obesity, DIO) rats, so as to provide scientific grounds for the development and utilization of CGA in early prevention and reversal of prediabetes.

Methods: Eight of forty-six male Sprague-Dawley rats were randomly selected as the normal diet group (CON group), and the rest were fed with high-fat diet. After 4 weeks, 24 high-fat-induced obese rats were screened according to the criteria and then randomly divided into high fat diet group (HFD group), 50% CGA group and 98% CGA group. Read More

View Article

Download full-text PDF

Source

[Enteral nutrition support reduces toxicity of chemotherapy in patients with advanced or metastatic esophageal cancer].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):261-268

Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education; VIP-II Gastrointestinal Cancer Division of the Department of Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Objective: To assess the impact of enteral nutrition support on response and toxicity of the first-line chemotherapy in those patients with advanced or metastatic esophageal cancer.

Methods: We collected the clinical data of 118 patients with unresectable advanced or metastatic esophageal cancer who received the first-line chemotherapy in our center from July 2014 to December 2016. All these 118 esophageal cancer patients were then divided into two groups: the nutrition group (received enteral nutrition support in addition to chemotherapy) and the control group (received chemotherapy only). Read More

View Article

Download full-text PDF

Source

[Efficacy and safety of oral pyrotinib in HER2 positive metastatic breast cancer: real-world practice].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):254-260

Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education; Department of Breast Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Objective: Pyrotinib, a novel irreversible pan-ErbB receptor tyrosine kinase inhibitor, showed promising antitumor activity and acceptable tolerability in phase II and phase III randomized clinical trials. We assessed the activity and safety of oral pyrotinib for human epidermal growth factor receptor 2 (HER2) positive metastatic breast cancer patients in the real world.

Methods: We retrospectively analyzed 72 HER2 positive metastatic breast cancer (MBC) patients who received oral pyrotinib based regimens at Beijing Cancer Hospital and other four hospitals (Peking University First Hospital, China-Japan Friendship Hospital, General Hospital of PLA, Peking University Third Hospital) from August 2018 to September 2019. Read More

View Article

Download full-text PDF

Source

[Effect of Fei-Liu-Ping ointment combined with cyclophosphamide on lung cancer cell proliferation and acidic microenvironment].

Authors:
L Geng J Lv J Fan

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):247-253

College of Management, Henan University of Chinese Medicine, Zhengzhou 450008, China.

Objective: To observe the effects of Fei-Liu-Ping ointment and chemotherapy on mice with lung cancer, and to explore the inherent mechanism of action from the point of acidic microenvironment and apoptosis.

Methods: First of all, the Lewis lung cancer transplanted mouse model was established. Therefore, they were treated by Fei-Liu-Ping ointment, cyclophosphamide, Fei-Liu-Ping ointment + cyclophosphamide and the saline as control. Read More

View Article

Download full-text PDF

Source

[Clinical evaluation of tumor-stroma ratio in pseudomyxoma peritonei from the appendix].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):240-246

Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

Objective: To evaluate the effect of tumor-stroma ratio (TSR) on disease progression and prognosis of pseudomyxoma peritonei (PMP) from the appendix.

Methods: The study included 30 PMP patients with complete individual patient data, who underwent cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) in Beijing Shijitan Hospital. Image-Pro Plus was used to quantitatively analyze the proportion of tumor and stromal areas in hematoxylin-eosin staining pathological images, from which TSR was derived. Read More

View Article

Download full-text PDF

Source

[Clinical value of serum isoform [-2] proprostate-specific antigen and its derivatives in predicting aggressive prostate cancer].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):234-239

Department of Clinical Laboratory, Peking University First Hospital, Beijing 100034, China.

Objective: To explore the clinical value of serum isoform [-2] proprostate-specific antigen (p2PSA) and its derivatives %p2PSA and prostate health index (PHI) in predicting aggressive prostate cancer (PCa).

Methods: The pre-operation serum and basic clinical data of 322 patients with PCa (including 143 patients diagnosed with PCa by transrectal ultrasound-guided prostate biopsy and 179 patients undergoing radical prostatectomy) in Peking University First Hospital were collected from August 2015 to May 2018. Serum total prostate-specific antigen (tPSA), free prostate antigen (fPSA) and fPSA/tPSA (f/t) and the p2PSA level of all these patients were measured on automatic immune analyzers DxI800, and then %p2PSA and PHI were calculated. Read More

View Article

Download full-text PDF

Source

[Palmitoylome profiling indicates that androgens promote the palmitoylation of metabolism-related proteins in prostate cancer-derived LNCaP cells].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):227-233

The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing 100730, China.

Objective: To explore potential therapeutic targets other than androgen-deprivation treatment for prostate cancer by screening the proteins induced by androgen at palmitoylation modification level in LNCaP cells.

Methods: The LNCaP cells were treated with androgen (Methyltrienolone, R1881, 5 nmol/L) or dimethyl sulfoxide (DMSO) for 24 h, and then labeled with alkynyl palmitic acid Alk-C16 (100 μmol/L). After that, the cells were collected, lysed, the total protein was extracted, agarose beads labeled with azide (1 mmol/L) were added, and the click-chemistry reaction was carried out at room temperature for 1 h. Read More

View Article

Download full-text PDF

Source

[Subcellular localization of GTPase of immunity-associated protein 2].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):221-226

School of Laboratory Medicine and Biotechnology, Institute of Molecular Immunology, Southern Medical University, Guangzhou 510515, China.

Objective: To analyze the subcellular localization of GTPase of immunity-associated protein 2 (GIMAP2) for the further functional study.

Methods: In the study, we first obtained the protein sequences of GTPase of immunity-associated protein 2 (GIMAP2) from National Center for Biotechnology Information (NCBI) database, and then performed a prediction analysis of its transmembrane structure, nuclear localization signal (NLS), nuclear export signal (NES) and subcellular localization through bioinformatics online tools. GIMAP2 gene amplified by PCR was inserted into the expression vector pQCXIP-mCherry-N1 and positive clones were selected by ampicillin resistance. Read More

View Article

Download full-text PDF

Source

[Interaction between PSF and cytokeratin 18 mediates PSF relocation to cell membrane and maintains chemosensitivity of myeloid leukemia].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):214-220

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.

Objective: To identify the chaperone of polypyrimidine tractor-binding protein-associated splicing factor (PSF) in myeloid leukemia cells, and to explore the mechanism and redistributive pattern to cell surface of PSF in chemo-sensitive HL60 cells and resistant HL60/DOX cells.

Methods: The eukaryotic expression vector of PSF was transfected with liposomes transiently, then flow cytometry was used to detect the expression level of PSF on the cell surface 24 h, 48 h and 72 h after vector transfections. We constructed a chimeric expression vector, streptavidin binding peptide (SBP)-PSF, meanwhile this vector was transfected and made SBP-PSF fusion protein overexpress. Read More

View Article

Download full-text PDF

Source

[Establishment and gene expression analysis of drug-resistant cell lines in hepatocellular carcinoma induced by sorafenib].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):207-213

Department of Laboratory, Ministry of Education Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital and Institute, Beijing 100142, China.

Objective: To establish the drug-resistant cell lines of hepatocellular carcinoma (HCC) induced by sorafenib, and to screen out the high expression genes in drug-resistant cell lines of HCC induced by sorafenib, then to explore the genes related to sorafenib resistance in hepatocellular carcinoma.

Methods: The human PLC and Huh7 cell lines were obtained, then the PLC and Huh7 drug-resistant cell lines were induced with sorafenib by using intermittent induction in vitro. CCK8 assay was used to detect the IC50 value of sorafenib for evaluation of drug sensitivity of hepatocellular carcinoma cell lines in PLC and Huh7. Read More

View Article

Download full-text PDF

Source

[Plunging ranula presenting as a giant retroauricular mass: A case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):193-195

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Plunging ranula is rare and manifests as the submandibular or submental cystic mass, without intra-oral abnormality. It usually causes misdiagnosis and malpractice. This article reported a case of plunging ranula that appeared as a massive mass located behind the left ear. Read More

View Article

Download full-text PDF

Source
February 2020

[Application and exploration of Smile Lite MDP portable photography system in aesthetic photography of anterior teeth].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):187-192

Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To explore the possibility of the Smile Lite MDP (Smile Lite Mobile Dental Photograph) portable dental photography system applying in anterior teeth aesthetic photography, and to provide the chance to simplify aesthetic photography process and facilitate communication among patients, dentists and dental technitians.

Methods: The Smile Lite MDP photography system combined with the smartphone were used to photograph the front occlusal phase photos of anterior teeth. The photographic conditions including the color temperature parameter, the Smile Lite MDP light position and the intensity settings were explored. Read More

View Article

Download full-text PDF

Source
February 2020

[Application of intravenous sedation in 2 582 cases of oral and maxillofacial surgery].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):181-186

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To analyze the clinical data of patients undergoing intravenous sedation in oral and maxillofacial surgery, to understand the epidemiological characteristics, to evaluate the efficacy and safety of intravenous sedation for oral surgery, and to summarize our experience.

Methods: We retrospectively reviewed the clinical data of patients undergoing intravenous sedation between January 2010 and December 2018 in the Department of Oral and Maxillofacial Surgery, Peking University School of Stomatology. The gender, age, source, disease types, the values of perioperative vital signs, the use of sedatives and analgesics, duration of surgery and sedation, effect of sedation during the operation and the postoperative anterograde amnesia were analyzed. Read More

View Article

Download full-text PDF

Source
February 2020

[Hybrid treatment for symptomatic long-segment chronic internal carotid artery occlusion without stump].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):177-180

Department of Interventional Radiology and Vascular Surgery, Peking University Third Hospital, Beijing 100191, China.

Objective: To summarize the preliminary experience of hybrid operation for the treatment of symptomatic long-segment chronic internal carotid artery occlusion (CICAO) without stump.

Methods: Clinical data of 12 patients of symptomatic long-segment CICAO without stump undergoing hybrid operation treatment from July 2015 to December 2017 were retrospectively analyzed. The safety and efficacy of hybrid operation for the treatment of symptomatic long-segment CICAO without stump were preliminarily assessed. Read More

View Article

Download full-text PDF

Source
February 2020

[Techniques enhancement for tissue expander/implant two-stage breast reconstruction].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):169-176

Department of General Surgery, Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate the outcomes of breast reconstruction with employing improved techniques throughout the tissue expander/implant two-stage breast reconstructed process, which involved the tissue expander placement, the saline filling intraoperatively and postoperatively, the implant selection, and the permanent implant replacement.

Methods: In this study, 68 patients who had been provided immediate or delayed tissue expander/implant two-stage breast reconstruction with autologous fat injection post-mastectomy in Peking University Third Hospital from April 2014 to September 2018 were involved, and the relevant information was analyzed retrospectively. The enhancements of the techniques, involving the incision selection, the expander placement, the principle of expansion, the management of capsule, the prosthesis selection, and the assisted reconstruction method were summarized, and the reconstruction outcomes were evaluated objectively through three-dimensional surface imaging. Read More

View Article

Download full-text PDF

Source
February 2020

[Musculoskeletal ultrasound findings of symptomatic joints in patients with systemic lupus erythematosus].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):163-168

Department of Rheumatology, Peking University First Hospital, Beijing 100034, China.

Objective: To investigate the types and distribution of musculoskeletal ultrasonographic changes of the symptomatic joints, their correlations with clinical manifestations in systemic lupus erythematosus (SLE) patients, as well as the differences of ultrasonographic changes from Rhupus syndrome [SLE overlapping with rheumatoid arthritis (RA)] patients.

Methods: In the study, 114 SLE patients who complained of arthralgia or arthritis from May 2014 to August 2017 and 15 Rhupus syndrome patients were recruited for ultrasound evaluation. Ultrasound scans of the symptomatic joint areas were completed. Read More

View Article

Download full-text PDF

Source
February 2020

[Prognosis factors analysis of patients with malignant solitary pulmonary nodules].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):158-162

Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.

Objective: To explore the prognosis factors that influence the postoperative survival rate in patients with malignant solitary pulmonary nodules and to provide a reference for the prognosis risk stratification of early lung cancer patients.

Methods: In this study, we retrospectively reviewed 172 patients who were admitted to Peking University First Hospital from April 2006 to December 2013. All cases were radiologically defined as solitary pulmonary nodule and were pathologically confirmed to be stage Ia non-small cell lung cancer after surgical procedure. Read More

View Article

Download full-text PDF

Source
February 2020

[Protective effect of cardiopulmonary fitness on patients with high risk of atherosclerotic cardiovascular disease].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):152-157

Department of Cardiology, Peking University Third Hospital; Institute of Vascular Medicine of Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of National Health Commission; Key Laboratory of Molecular Cardiovascular Science of Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.

Objective: To evaluate the effects of cardiopulmonary fitness on arteriosclerotic cardiovascular disease (ASCVD) events in patients with different risks of ASCVD.

Methods: This study enrolled 544 non ASCVD patients who underwent cardiopulmonary exercise testing in Peking University Third Hospital from September 2016 to April 2018. ASCVD overall risk assessment was conducted according to "Chinese Guidelines for the Prevention and Treatment of Adult Dyslipidemia". Read More

View Article

Download full-text PDF

Source
February 2020

[Preliminary study on three digital analysis methods for analyzing the distribution and area of occlusal contacts].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):144-151

Center of Digital Dentistry, Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To analyze the distribution and area of occlusal contacts of clinical dental model using three kinds of digital analysis methods, to compare the results of these methods and traditional occlusal analysis method, and to further analyze the characteristics of each digital analysis method.

Methods: A set of plaster models of normal subjects was selected. The models were scanned by lab scanner 3shape E4 and the files were exported in a stereolithography file format. Read More

View Article

Download full-text PDF

Source
February 2020

[Accuracy of intercuspal occlusion in 3D reconstruction with the dental articulator position method].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):138-143

Center of Digital Dentistry, Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To evaluate the three-dimensional (3D) reconstruction accuracy of the intercuspal occlusion (ICO) of the dental casts, by the dental articulator position method, and provide a reference for clinical application.

Methods: The standard dental casts in ICO were mounted on average values articulator, and five pairs of milling resin cylinders were respectively attached to the base of both the casts. 100 μm articulating paper and occlusal record silicone rubber were used to detect the occlusal contact number between the posterior teeth of casts mounted on articulator in ICO. Read More

View Article

Download full-text PDF

Source
February 2020

[Accuracy of three intraoral scans for primary impressions of edentulous jaws].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):129-137

Center of Digital Dentistry, Faculty of Prosthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Research Center of Engineering and Technology for Digital Dentistry of Ministry of Health & Beijing Key Laboratory of Digital Stomatology & National Clinical Research Center for Oral Diseases, Beijing 100081, China.

Objective: To provide a reference for using intraoral scanners for making clinical diagnostic dentures of edentulous jaws by comparing the accuracy of three intraoral scanners for primary impression and jaw relation record of edentulous jaws.

Methods: This study contained 6 primary impressions of the edentulous patients. Each of the impressions consisted of the maxillary primary impression, the mandibular primary impression and the jaw relation record. Read More

View Article

Download full-text PDF

Source
February 2020

[Analysis of the relationship among maxillary anterior teeth width, anterior arch perimeter and anterior segment depth].

Authors:
P Wang D J Li J Z Liu

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):124-128

Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To analyze the relationship between the width of the maxillary anterior teeth and the anterior arch perimeter, to analyze the change rule of the width of the anterior teeth and the anterior arch perimeter, when altered the convexity of the anterior arch, with the width of the maxillary anterior arch keeping constant, and to provide a reliable basis for later digitized and personalized aesthetic analysis of front teeth.

Methods: In the study, 61 front teeth complete and well-arranged models had been selected from the working models after the prostheses in Department of Prosthodontics, Peking University School and Hospital of Stomatology, including 22 male models and 39 female models. A photograph was taken from the occlusal surface of each model using the fixed magnification with a single lens reflex camera. Read More

View Article

Download full-text PDF

Source
February 2020

[Application of computer-assisted design for anterolateral thigh flap in oral and maxillofacial reconstruction].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):119-123

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To investigate the feasibility and accuracy of using digital technology to design anterolateral thigh flap (ALTF) in oral and maxillofacial defect reconstruction.

Methods: Ten cases underwent oral and maxillofacial defects reconstruction with ALTFs in Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology from June 2019 to Oct. 2019 were enrolled. Read More

View Article

Download full-text PDF

Source
February 2020

[Evaluation of mandibular stability and condylar volume after orthognathic surgery in patients with severe temporomandibular joint osteoarthrosis].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):113-118

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To investigate the effect of preoperative condylar condition for mandible retrognathism deformities with severe temporomandibular joint osteoarthrosis on the stability of the jaw after orthognathic surgery and on the postoperative condylar volume changes.

Methods: In this retrospective study, from 2014 to 2019, 37 patients including 1 male and 36 female, aged between 21 to 34 years old with an average age of (28.03±6. Read More

View Article

Download full-text PDF

Source
February 2020

[Visual sensitivity threshold of lateral view of nasolabial Angle changes in edentulous jaw patients].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):107-112

Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To study the visual sensitivity threshold of physician's naked eye to the difference of nasolabial angle in edentulous jaw patients, and to provide a reference value for the study of aesthetic evaluation of soft tissue profile for the difference of nasolabial angle that can be recognized by human eyes.

Methods: Three-dimensional facial images of three edentulous patients with different diagnostic dentures introoral were obtained. Lateral screenshots of each patient's three-dimensional facial image with the same scale were obtained by using reverse engineering software (Geomagic studio 2014). Read More

View Article

Download full-text PDF

Source
February 2020

[Study on bone volume harvested from the implant sites with different methods].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):103-106

Second Clinical Division, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100101, China.

Objective: To compare the volume of autogenous bone particles harvested utilizing different techniques and various implant systems during implant surgery, and to determine the advantageous method to collect autogenous bone particles.

Methods: Homogeneous epoxy resin simulated jaw bone model was enrolled. Bicon, Bego implant systems and Straumann tissue level implant systems were utilized. Read More

View Article

Download full-text PDF

Source
February 2020

[Application of β-TCP for bone defect restore after the mandibular third molars extraction: A splitmouth clinical trial].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):97-102

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To evaluate the effect of bone defect regeneration and the periodontal status of the second molars after mandibular third molars extraction using β-tertiary calcium phosphate (β-TCP) in the test side compared with the spontaneously healed side. To the bone defect of mandibular second molars as a result of surgical removal of impacted mandibular third molars is a common phenomenon, many research shows that the mandibular second molars alveolar bone regeneration was about 1.5 mm and the periodontal pocket >7 mm was greater than 43. Read More

View Article

Download full-text PDF

Source
February 2020

[Feasibility of Delaire cephalometric analysis to predict the ideal sagittal position of the maxilla and chin for surgery-first patients in orthognathic surgery].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):90-96

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Disease & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: There is no universally accepted method for determining the ideal sagittal position of the maxilla in orthognathic surgery. The purpose of this study was to compare how well the Delaire's cephalometric analysis correlated with postoperatively findings in patients who underwent orthognathic surgery planned using other cephalometric analyses, as well as to evaluate the feasibility of the Delaire's cephalometric analysis in predicting the ideal sagittal position of the maxilla and chin.

Methods: In the study, 35 patients with skeletal Class III malocclusion were involved and met the criteria. Read More

View Article

Download full-text PDF

Source
February 2020

[Parotid CT imaging reporting and data system: A preliminary study].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):83-89

Department of Oral and Maxillofacial Radiology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To establish a Parotid Imaging Reporting and Data System (PI-RADS) for CT diagnosis of the parotid gland neoplasms and to investigate the clinical applicable value and feasibility of PI-RADS.

Methods: Patients who had been diagnosed with primary parotid gland neoplasms and had received surgical treatments in Peking University School and Hospital of Stomatology during the period of January 2013 to December 2016 were included in this study. The diagnoses were confirmed by the postoperative pathological examinations in all the patients. Read More

View Article

Download full-text PDF

Source
February 2020

[Alveolar crest and relevant analysis of labial side of anterior teeth on skeletal Angle class III patients].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):77-82

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China.

Objective: To measure the distance from cemento-enamel junction (CEJ) to alveolar crest (AC) of labial side of anterior teeth on skeletal Angle class III patients under direct vision during periodontal bone augmentation surgery and to make relevant analysis to find the relevant factors.

Methods: In the study, 46 skeletal Angle class III patients (10 males and 36 females) received periodontal bone augmentation surgery of anterior teeth were included, with 67 jaws (27 maxillae and 40 mandibles) and 400 anterior teeth (161 maxillary anterior teeth and 239 mandibular anterior teeth). The mean age was 23. Read More

View Article

Download full-text PDF

Source
February 2020

[Associations of impaired glucose metabolism with chronic peridontitis in pre-diabetes patients].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):71-76

First Clinical Division, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To investigate the associations of impaired glucose metabolism and insulin resistance with chronic periodontitis in pre-diabetes patients.

Methods: A cross-sectional analysis was conducted and we included a total of 171 pre-diabetes patients aged 30-65 years, free of diabetes. pre-diabetes was defined as impaired fasting glucose (IFG) [fasting glucose (FG): 6. Read More

View Article

Download full-text PDF

Source
February 2020