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    Ocular inflammatory signs observed in a cohort of Spanish patients with Behcet disease and ocular inflammation.
    Eur J Ophthalmol 2008 Jul-Aug;18(4):563-566
    Department of Ophthalmology, Hospital Clinico Universitario San Carlos-Universidad Complutense, Madr.
    Purpose: To study the clinical characteristics of a cohort of Spanish patients diagnosed with Behcet disease and who also presented ocular inflammation.

    Methods: Thirty cases of Behcet disease were studied retrospectively. The authors studied age distribution, distribution by sex, clinical course, laterality, type of uveitis, secondary glaucoma, corneal involvement, hypopyon, iris-lens synechiae, secondary cataract, cystoid macular edema (CME), and papillitis (optic neuritis). Read More

    Increased vascular endothelial growth factor levels in aqueous humor and serum of patients with quiescent uveitis.
    Eur J Ophthalmol 2007 Nov-Dec;17:938-942
    Uveitis Center, Department of Ophthalmology, Policlinico Umberto I University Hospital, Roma - Italy.
    Purpose: Vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) are angiogenic mediators that share a significant proinflammatory activity. Both substances have been suggested to play a key role in uveitis pathogenesis. The authors analyzed VEGF and IL-8 levels in the aqueous humor and serum of patients with different types of uveitis during a quiet phase of the disease. Read More

    Association of sleep quality in Behcet disease with disease activity, depression, and quality of life in Korean population.
    Korean J Intern Med 2017 Feb 16. Epub 2017 Feb 16.
    Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
    Background/aims: Sleep disturbance is prime concern in patients with Behcet disease. The purpose of this study was to find out the effects of sleep quality, in Korean patients suffering from Behcet disease. We further investigated the relationship between depression, quality of life and the clinical findings of Behcet disease. Read More

    Circulating NK cells and their subsets in Behçet's Disease.
    Clin Exp Immunol 2017 Feb 7. Epub 2017 Feb 7.
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Blizard Building, 4 Newark Street, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK.
    Behçet's Disease (BD) is an auto-inflammatory, chronic relapsing/remitting disease of unknown aetiology with both innate and acquired immune cells implicated in disease pathogenesis. Peripheral blood Natural Killer (NK) cells and their CD56(Dim) /CD56(Bright) subsets were surface phenotyped using CD27 and CD16 surface markers in 60 BD patients compared to 60 healthy controls (HCs). Functional potential was assessed by production of interferon (IFN)-γ, Granzyme B, Perforin and the expression of degranulation marker CD107a. Read More

    HAX1 mutation positive children presenting with haemophagocytic lymphohistiocytosis.
    Br J Haematol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Paediatric Haematology-Oncology, Dr. Behçet Uz Children Research and Training Hospital, Izmir, Turkey.
    The genetic basis of haemophagocytic lymphohistiocytosis (HLH) has not been elucidated in 10% of affected patients. In this study, we report four HLH episodes in three patients with HAX1 gene mutations. We screened the mutations associated with congenital neutropenia (CN) because the neutropenia persisted following HLH treatment. Read More

    [The value of different antibodies detection in diagnosis of rheumatism with uveitis].
    Zhonghua Yi Xue Za Zhi 2017 Jan;97(4):285-290
    Department of Clinical Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
    Objective: To investigate the value of HLA-B27 antigen, antinuclear antibody (ANA), anti-dsDNA and Anti-Neutrophil Cytoplasmic Antibodies (ANCA) detection in diagnosis of rheumatism with uveitis. Methods: Seven hundred and twenty four newly diagnosed patients with non-infection uveitis in Beijing Tongren Hospital from March 2012 to March 2016 who long-term lived in Beijing and its surrounding areas were continuously enrolled. HLA-B27 antigen expressions in peripheral blood lymphocytes and ANA, anti-dsDNA and ANCA levels in serum were tested. Read More

    Behcet's disease.
    Clin Med (Lond) 2017 Feb;17(1):71-77
    University of Liverpool and director, National Behcet's Syndrome Centre of Excellence, Aintree University Hospital, Liverpool, UK.
    Behçet's disease (BD) is a chronic relapsing and remitting vasculitis of unknown aetiology. It has the capacity to affect almost all organ systems because of its potential to involve both arteries and veins of all sizes, resulting in significant organ-threatening morbidity and mortality. Traditionally known as the 'silk road' disease, it has a worldwide occurrence. Read More

    Multiple Aneurysms and a Transplanted Kidney in Behçet Disease.
    Vasc Endovascular Surg 2017 Feb 1;51(2):108-110. Epub 2017 Feb 1.
    1 Department of Vascular Surgery, University Hospital Birmingham, Birmingham, United Kingdom.
    Arterial manifestation of Behçet disease represents a challenging clinical scenario with a potential for fatal complications. This case depicts the surgical management of a 4.5-cm infrarenal aortic aneurysm and a 6-cm left renal artery aneurysm in a patient with known Behçet disease. Read More

    Treating an Adolescent with Long QT Syndrome for Bipolar Disorder: A Case Presentation.
    Psychopharmacol Bull 2017 Jan;47(1):33-39
    Drs. Önen, Kutlu, Erkuran, MD, Dr. Behcet Uz Children's Hospital Department of Child and Adolescent Psychiatry, Izmir, Turkey.
    Objectives: Long QT syndrome (LQTS) is described as the development of sudden syncope attacks or death as a result of ventricular tachycardia (VT) episodes that might be observed as elongated QT interval in electrocardiography (ECG). Implantable Cardioverter Defibrillator (ICD) is recommended as first-line treatment for the condition in guidelines. We aimed to present an adolescent recently diagnosed with Bipolar Disorder (BD) who had LQTS that was treated with ICD, discussing her follow up and treatment along with relevant literature. Read More

    Panniculitis: A summary.
    Semin Diagn Pathol 2016 Dec 27. Epub 2016 Dec 27.
    Section of Dermatopathology,Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:
    The diagnosis of panniculitis is felt to be a confusing topic by some pathologists. This summarical article presents inflammatory diseases of the subcutis in a systematic fashion, based on whether they are centered on fibrovascular septa or the adipose lobules, and whether morphologic vasculitis is present or not. Septocentric, non-vasculitis disorders include erythema nodosum, panniculitis that follows the use of "biological" therapeutic agents, lipodermatosclerosis, post-irradiation panniculitis, morphea profunda, and necrobiosis lipodica profunda. Read More

    Clinical phenotypes of Korean patients with Behcet disease according to gender, age at onset, and HLA-B51.
    Korean J Intern Med 2017 Jan 12. Epub 2017 Jan 12.
    Department of Rheumatology, Gachon University Gil Medical Center, Incheon, Korea.
    Background/aims: The clinical manifestations of Behcet disease (BD) have been reported to differ according to country, region, and race. Gender, onset age, and human leukocyte antigen (HLA)-B51 have also been known as the factors that influence the clinical features of BD. The aim of this study is to investigate the clinical phenotypes of Korean patients who visited the rheumatology clinic with BD with respect to gender, onset age, and HLA-B51. Read More

    Ventricular endomyocardial fibrosis in a pregnant female with Behçet's disease.
    Asian Cardiovasc Thorac Ann 2017 Jan 1:218492316687177. Epub 2017 Jan 1.
    5 Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran.
    A 32-year-old pregnant woman, diagnosed with Behçet's disease 6 months earlier, presented with recent mild hemoptysis and exertional dyspnea. Transthoracic echocardiography showed an enlarged dysfunctional right ventricle. A large hypoechoic triangular-shaped mass was seen attached to the inner right ventricular wall, filling the cavity. Read More

    Chronic bowel inflammation and inflammatory joint disease: Pathophysiology.
    Joint Bone Spine 2017 Jan 3. Epub 2017 Jan 3.
    Lille Inflammation Research International Center (LIRIC), U995, University Lille, Inserm, CHU Lille, 59000 Lille, France. Electronic address:
    Bowel inflammation is closely linked to chronic joint inflammation. Research reported in the 1980s demonstrated bowel inflammation with gross and microscopic pathological features identical to those of Crohn's disease in over 60% of patients with spondyloarthritis (SpA). Numerous prospective studies have evidenced joint involvement in patients with chronic inflammatory bowel disease (IBD) and bowel inflammation in patients with SpA. Read More

    Epigenetic Changes in Chronic Inflammatory Diseases.
    Adv Protein Chem Struct Biol 2017 18;106:139-189. Epub 2016 Oct 18.
    Laboratory for Epigenetics and Environment, Centre National de Génotypage, CEA-Institut de Génomique, Evry, France. Electronic address:
    The number of people diagnosed with chronic inflammatory diseases has increased noteworthy in the last 40 years. Spondyloarthritis (SpA), inflammatory bowel diseases (IBD), and psoriasis are the most frequent chronic inflammatory diseases, resulting from a combination of genetic predisposition and environmental factors. Epigenetic modifications include DNA methylation, histone modifications, and small and long noncoding RNAs. Read More

    Panax Notoginseng Saponin Controls IL-17 Expression in Helper T Cells.
    J Ocul Pharmacol Ther 2017 Jan 4. Epub 2017 Jan 4.
    1 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .
    Purpose: Panax Notoginseng, a traditional Chinese medicine, is known as an anti-inflammatory herb. However, the molecular mechanism by which it controls helper T cell mediated immune responses is largely unknown.

    Methods: Naive CD4(+) T cells isolated from healthy donors, patients with Behcet's disease, and C57BL/6 mice were polarized into Th1, Th17, and Treg cells. Read More

    Cardiovascular Involvement in Behçet Disease: Clinical Implications.
    Int J Angiol 2016 Dec 5;25(5):e84-e86. Epub 2015 Jun 5.
    Heart Institute, HaEmek Medical Center, Afula, Israel; Rappaport Faculty of Medicine, Technion, Haifa, Israel.
    Behçet disease (BD) is a multisystem disorder, with vasculitis as its underlying pathological process, in contrast to the classic triad of recurrent oral and genital ulcerations, with uveitis. Vascular involvement in BD includes venous thrombosis, arterial occlusion, and pulmonary artery and aortic aneurysm formation. Cardiac involvement is rare and often obscure. Read More

    Adaptive Optics Imaging in Retinal Vasculitis.
    Ocul Immunol Inflamm 2016 Dec 23:1-7. Epub 2016 Dec 23.
    c Department of Cornea and Refractive Surgery , Narayana Nethralaya , Bangalore , India.
    Purpose: To study the sheathing of retinal vasculitis in various systemic autoimmune diseases using adaptive optics imaging (AOI).

    Methods: Prospective, observational case series with six patients: Behçet disease (n = 1); systemic lupus erythematosus (n = 1); idiopathic retinal vasculitis (n = 2); granulomatosis with polyangiitis (n = 1); and Takayasu aorta arteritis (n = 1). Fundus photograph (FP), fundus fluorescein angiography (FFA) were done in all cases at presentation. Read More

    Neuro-Behcet disease presenting as a solitary cerebellar hemorrhagic lesion: a case report and review of the literature.
    J Med Case Rep 2016 Dec 20;10(1):360. Epub 2016 Dec 20.
    Department of Neurology, Chungbuk National University College of Medicine, Chungbuk National University Hospital, 776 1Sunhwan-ro, Seowon-ku, Cheongju-si, Chungbuk, 361-711, South Korea.
    Background: Behcet's disease is a heterogeneous, multisystem, inflammatory disorder of unknown etiology. The classic triad of oral and genital ulcerations in conjunction with uveitis was originally described by the Turkish dermatologist Hulusi Behcet in 1937, but associated symptoms of the cardiovascular, central nervous, pulmonary, and gastrointestinal systems were later identified. In fact, Behcet's disease with neurological involvement (neuro-Behcet's disease) is not uncommon. Read More

    Association of Reduced Heme Oxygenase-1 with Decreased MicroRNA-196a2 Expression in Peripheral Blood Mononuclear Cells of Patients with Intestinal Behcet's Disease.
    Ann Clin Lab Sci 2016 Dec;46(6):675-679
    Department of Gastroenterology, Huadong Hospital, Fudan University, Shanghai, China
    Aims: To examine the expression of miRNAs and mRNAs of heme oxygenase 1 (HO-1) in patients with active intestinal Behcet's disease (BD).

    Methods: Peripheral blood mononuclear cells (PBMCs) were obtained from BD patients with active ileocecal ulcers or from healthy donors. Expression levels of four miRNAs were studied using real-time PCR. Read More

    Influence of Behçet's disease on first and second trimester serum screening markers.
    J Obstet Gynaecol Res 2016 Dec 17. Epub 2016 Dec 17.
    Department of Perinatology, Zekai Tahir Burak Women's Health Education and Training Hospital, Ankara, Turkey.
    Aim: Behçet's disease (BD) is a rare and multisystemic vasculitis disease. In this study, we investigated whether BD had any effect on the biochemical components of first and second trimester aneuploidy screening tests.

    Methods: A case-control retrospective study was conducted with 32 pregnant women with BD and 60 healthy pregnant women as controls. Read More

    Rupture of celiac trunk aneurysm in patient with Behçet Disease.
    Rev Col Bras Cir 2016 Sep-Oct;43(5):404-406
    Medical School, Porto Alegre Federal University of Health Sciences (UFCSPA), Porto Alegre, RS, Brazil.
    We report a case of a ruptured aneurysm of the celiac trunk in a 32-year-old, male patient with Behçet Disease (BD). Aneurysm resection was performed and the patient is well during a follow up of 32 months. To our knowledge, this is the first reported case of a ruptured celiac trunk aneurysm successfully treated in a patient with BD. Read More

    Intracardiac thrombus in Behçet's disease.
    Reumatismo 2016 Dec 16;68(3):148-153. Epub 2016 Dec 16.
    Department of Internal Medicine, University Hospital of La Rabta, Tunis.
    Behçet's disease (BD) is a multisystem inflammatory disorder. Intracardiac thrombus (ICT) formation is an uncommon but important complication of BD. Of the cases of Behçet's disease, we selected those with ICT. Read More

    Behçet syndrome: the vascular cluster.
    Turk J Med Sci 2016 Nov 17;46(5):1277-1280. Epub 2016 Nov 17.
    Department of Rheumatology, Cerrahpaşa Faculty of Medicine, İstanbul University, İstanbul, Turkey.
    Although skin-mucosa lesions are common in almost all patients with Behçet syndrome (BS), clinical properties may differ from one patient to another. Within BS, there are subsets with different organ involvement and hence probably different pathological pathways. These subsets can be described as a) solo skin-mucosa disease with no major organ involvement, b) eye disease, c) seronegative spondyloarthropathy-like disease (arthritis, enthesopathy, and folliculitis), d) Crohn-like disease, and finally the topic of this chapter: e) vascular disease. Read More

    Orofacial manifestations in patients with inflammatory rheumatic diseases.
    Best Pract Res Clin Rheumatol 2016 Oct 18;30(5):826-850. Epub 2016 Nov 18.
    Birmingham Behçet's Syndrome Centre of Excellence, Sheldon Block, Birmingham and Midland Eye Centre, City Hospital, Dudley Road, Birmingham, B18 7QH, UK. Electronic address:
    The main orofacial manifestation of the inflammatory rheumatic diseases is that of Sjögren's syndrome. In addition, there is a constellation of orofacial manifestations of the inflammatory rheumatic diseases, many of which are extra-articular with some constituting presenting signs of the underlying rheumatic disease. This review will discuss the orofacial manifestations in a variety of connective tissue diseases and will also allude to the oral adverse drug reactions that may occur as a consequence of therapy. Read More

    Cytotoxic Th1 and Th17 cells infiltrate the intestinal mucosa of Behcet patients and exhibit high levels of TNF-α in early phases of the disease.
    Medicine (Baltimore) 2016 Dec;95(49):e5516
    aDepartment of Experimental and Clinical Medicine, University of Florence bDepartment of Surgery and Translational Medicine cResearch Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena dSOD Interdisciplinary Internal Medicine, Center for Autoimmune Systemic Diseases -Behçet Center and Lupus Clinic - AOU Careggi eRheumatology and Clinical Immunology, Humanitas Research Hospital fBIOMETRA Department, University of Milan, Milan, Italy.
    Background: Gastrointestinal involvement is one of the most serious in Behçet disease, potentially leading to severe complications. Aim of this study was to investigate at mucosal level the T-cell responses in Behçet patients with early intestinal involvement.

    Methods: We isolated T cells from intestinal mucosa of 8 patients with intestinal symptoms started within 6 months. Read More

    Changing epidemiology of non-cystic fibrosis bronchiectasis.
    Turk J Pediatr 2016 ;58(1):19-26
    Department of Pediatrics, Balıkesir University Faculty of Medicine Balıkesir, Turkey.
    Non-cystic fibrosis bronchiectasis again becomes a major health problem due to inappropriate antibiotic use and increasing frequency of protracted bacterial bronchitis. The aim was to determine the changes in etiology of bronchiectasis. Patients who admitted to Behçet Uz Children Hospital between 2005 and 2015 (n=110) were retrospectively examined. Read More

    Polymorphisms of Promoter Region of TNF-α Gene in Iranian Azeri Turkish Patients with Behçet's Disease.
    J Korean Med Sci 2017 Jan;32(1):33-37
    Liver & Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
    Behçet's disease (BD) is a complex chronic relapsing inflammatory disorder of unknown etiology. Alterations of the tumor necrosis factor (TNF) expression related to the polymorphic alleles of TNF gene may implicate a pathogenetic role in increased activity of this cytokine in BD. A current study aimed at investigating the possible association between BD and its clinical features in Iranian Azeri Turks with two functional TNF-α gene polymorphisms (at the positions of -238 and -857). Read More

    Assessment of early atherosclerosis and left ventricular dysfunction in children with 21-hydroxylase deficiency.
    Clin Endocrinol (Oxf) 2016 Nov 7. Epub 2016 Nov 7.
    Division of Pediatric Endocrinology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
    Aim: We analysed 25 children with 21-hydroxylase deficiency who received glucocorticoid and/or mineralocorticoid treatment for at least 12 months to determine the effects of the disease and its treatment on vascular structures and ventricular function.

    Methods: Twenty-five patients with 21-hydroxylase-deficient congenital adrenal hyperplasia (CAH) and 25 control subjects were enrolled into this observational, cross-sectional study. The patients were investigated in terms of fasting blood glucose and insulin; fasting serum lipid profile; serum 17-hydroxyprogesterone; dehydroepiandrosterone sulphate; androstenedione; and adrenocorticotropic hormone. Read More

    The value of endografts in the surgical management of arterial lesions secondary to Behçet disease.
    J Vasc Surg 2017 Feb 23;65(2):471-477. Epub 2016 Nov 23.
    Division of Vascular Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
    Background: This study summarizes our experience in the surgical management of arterial lesions secondary to Behçet disease (BD) and assesses the value of endografts.

    Methods: Data from BD patients with arterial lesions managed surgically in our center from January 1998 to December 2015 were studied retrospectively. Surgical procedures, graft selection, graft-related complications, and retreatments were analyzed. Read More

    Behçet's disease: How to diagnose and treat vascular involvement.
    Best Pract Res Clin Rheumatol 2016 Apr 16;30(2):279-295. Epub 2016 Sep 16.
    University of Istanbul, Cerrahpasa Medical Faculty, Department of Medicine, Division of Rheumatology, Istanbul 81310, Turkey. Electronic address:
    Behçet's disease is a multisystem disorder with unknown etiology and a unique geographic distribution. The disease is characterized by recurrent skin-mucosa lesions and sight-threatening panuveitis. Vascular involvement, which is more common and more severe among males, has also equally characteristic features such as affecting mostly veins, having a significant tendency for thrombosis, and running a relapsing course. Read More

    Mean platelet volume as a marker for differentiating disease flare from infection in Behçet's disease.
    Int J Rheum Dis 2016 Nov 25. Epub 2016 Nov 25.
    Department of Rheumatology, Gachon University Gil Medical Center, Incheon, Korea.
    Aim: The aim of this study was to investigate the association between mean platelet volume (MPV) and clinical manifestations, disease activity or infection in patients with Behçet's disease (BD).

    Methods: In total, 193 patients diagnosed with BD according to the international criteria for BD were enrolled. Demographic data, clinical manifestations and laboratory results were collected by medical interviews and reviewing medical records. Read More

    Global Deformation Parameters Response to Exercise in Adolescents with Repaired Tetralogy of Fallot.
    Pediatr Cardiol 2016 Nov 23. Epub 2016 Nov 23.
    Department of Pediatric Cardiology, Izmir Katip Celebi University Medical Faculty, Izmir, Turkey.
    Exercise stress echocardiography is rarely used in the follow-up of children with congenital heart disease following surgical repair. There are no data on global longitudinal strain (GLS) and global circumferential strain (GCS) during exercise in adolescents with repaired tetralogy of Fallot (TOF). The purpose of this prospective study was to investigate GLS and GCS using speckle tracking two-dimensional echocardiography (2D-STE) at rest and during exercise in adolescents with repaired TOF. Read More

    Decreased Activity and Genetic Polymorphisms of CYP2C19 in Behçet's Disease.
    Basic Clin Pharmacol Toxicol 2016 Nov 22. Epub 2016 Nov 22.
    Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
    Behçet's disease (BD) is a systemic autoimmune disorder. Cytochrome P450 enzymes (CYPs) are responsible for various drug metabolism reactions as well as those of endogenous substances which may be associated with autoimmune disease susceptibility. Recently, we reported that in patients with BD, CYP2C9 seems to be down-regulated due to inflammation. Read More

    Trichorhinophalangeal syndrome type II presenting with short stature in a child.
    Arch Argent Pediatr 2016 Dec;114(6):e403-e407
    Ankara University Faculty of Medicine, Department of Medical Genetics, Ankara, Turkey.
    Trichorhinophalangeal syndrome type II (TRPSII) (synonym: Langer-Giedon syndrome) is a rare autosomal dominant contiguous gene syndrome, resulting from a microdeletion encompassing the EXT1 and the TRPS1 gene at 8q24 (MIM#150230). This syndrome combines the clinical features of two autosomal dominant disorders, trichorhinophalangeal syndrome type I (MIM#190350) and hereditary multiple osteochondromas type I (MIM # 133700). TRPSII is characterized by sparse scalp hair, a long nose with a bulbous tip, long flat philtrum, cone-shaped epiphyses of the phalanges, retarded bone age in infancy and multiple cartilaginous osteochondromas. Read More

    Is ketogenic diet treatment hepatotoxic for children with intractable epilepsy?
    Seizure 2016 Dec 13;43:32-38. Epub 2016 Nov 13.
    Behçet Uz Children Hospital, Division of Pediatric Neurology, Izmir, Turkey.
    Purpose: Long-term ketogenic diet (KD) treatment has been shown to induce liver steatosis and gallstone formation in some in vivo and clinical studies. The aim of this retrospective study was to evaluate the hepatic side effects of KD in epileptic children.

    Method: A total of 141 patients (mean age: 7. Read More

    Dietary and Non-Dietary Triggers of Oral Ulcer Recurrences in Behçet's Disease.
    Arthritis Care Res (Hoboken) 2016 Nov 18. Epub 2016 Nov 18.
    Department of Internal Medicine, Hospital Saint-Louis, University Paris Diderot, Paris.
    Objectives: The nature and impact of food and other external triggers in recurrences of Behçet's disease (BD)-related oral ulcers (OUs) remain unknown. This survey investigated dietary and non-dietary triggers of BD-related OU recurrences.

    Methods: Patients with BD who were followed in 7 French hospital departments completed a self-administered patient questionnaire. Read More

    Development of Pulmonary Artery Aneurysms Due to Behçet's Disease and Resolution after Treatment.
    Intern Med 2016;55(22):3337-3340. Epub 2016 Nov 15.
    Department of Respiratory Medicine, The University of Tokyo, Japan.
    We herein describe a patient with Behçet's disease in whom we followed the development and resolution of pulmonary artery aneurysms. He presented with intermittent hemoptysis, pulmonary thromboembolism was initially diagnosed, and anticoagulant therapy was started. Over the next several months, the expansion of pulmonary arteries was noted. Read More

    Pediatric intestinal Behçet disease complicated by myeloid malignancies.
    Int J Hematol 2017 Mar 15;105(3):377-382. Epub 2016 Nov 15.
    Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan.
    Behçet disease (BD) is rarely seen in children. Its clinical manifestations are believed to differ between pediatric and adult patients. The characteristics of BD complicated by myelodysplastic syndrome (MDS) are well established for adult patients; however, because only a few cases of pediatric-onset BD complicated by MDS have been reported, its clinical characteristics remain unknown. Read More

    Neonatal Behçet's disease with Raynaud phenomenon.
    J Neonatal Perinatal Med 2016 ;9(4):423-425
    We report a new clinical manifestation of neonatal Behcet's disease. A newborn from a mother with active Behcet's disease during pregnancy, who develops vasomotor phenomena (Raynaud) with oral ulcerations in the second day of life. Neonatal mucocutaneous lesions have been reported previously in few newborns of pregnant women with active Behçet disease. Read More

    Canaliculitis Awareness.
    Turk J Ophthalmol 2016 Jan 5;46(1):25-29. Epub 2016 Jan 5.
    Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
    Objectives: To evaluate the demographic characteristics, treatment, and results of patients with canaliculitis.

    Materials And Methods: Medical records including the demographic characteristics, clinical findings, and treatment outcomes of patients diagnosed and treated for canaliculitis between September 2009 and March 2014 were analyzed retrospectively.

    Results: The median age of the 7 canaliculitis patients consisting of 4 women and 3 men was 49 (range 8-58) years. Read More

    Clinical Patterns and Causes of Intraocular Inflammation in a Uveitis Patient Cohort from Egypt.
    Ocul Immunol Inflamm 2016 Oct 26:1-9. Epub 2016 Oct 26.
    c International Eye Clinic, Orouba square , Sohag , Egypt.
    Purpose: To analyze the patterns and causes of intraocular inflammation in patients attending uveitis referral clinics in Egypt.

    Methods: The study included 454 patients with uveitis examined both at the Department of Ophthalmology, Alexandria Faculty of Medicine, and tertiary uveitis referral clinics in Cairo and the International Eye Clinic in Upper Egypt, between August 2013 and March 2016. All patients had a comprehensive ocular examination and systemic work-up. Read More

    One year in review 2016: Behçet's syndrome.
    Clin Exp Rheumatol 2016 Sep-Oct;34(6 Suppl 102):10-22. Epub 2016 Oct 13.
    Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Turkey.
    Several articles highlighting the epidemiology, pathogenesis, clinical features, treatment modalities and disease assessment of Behçet's syndrome (BS) have been published during the last year. Clinical and radiological features of lower extremity deep vein thrombosis due to BS can be quite different than those found in thrombosis due to other causes; additionally, frequency of post-thrombotic syndrome is significantly increased in BS. Some clinical and colonoscopic features are useful in differentiating BS from Crohn's disease. Read More

    Literature mining, gene-set enrichment and pathway analysis for target identification in Behçet's disease.
    Clin Exp Rheumatol 2016 Sep-Oct;34(6 Suppl 102):101-110. Epub 2016 Oct 18.
    Department of Renal Medicine, Box 57, Addenbrooke's Hospital, Cambridge, UK.
    Objectives: To use literature mining to catalogue Behçet's associated genes, and advanced computational methods to improve the understanding of the pathways and signalling mechanisms that lead to the typical clinical characteristics of Behçet's patients. To extend this technique to identify potential treatment targets for further experimental validation.

    Methods: Text mining methods combined with gene enrichment tools, pathway analysis and causal analysis algorithms. Read More

    Ocular Behçet's disease is less complicated with allergic disorders. A nationwide survey in Japan.
    Clin Exp Rheumatol 2016 Sep-Oct;34(6 Suppl 102):111-114. Epub 2016 Oct 25.
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Objectives: Behçet's disease (BD) is a systemic inflammatory disorder polarised to the Th1 and Th17 immune systems. Allergic diseases are polarised to the Th2 immune system. The aim of the present study is to investigate the prevalence of allergic diseases in patients who have BD. Read More

    Bronchial artery enlargement may be the cause of recurrent haemoptysis in Behçet's syndrome patients with pulmonary artery involvement during follow-up.
    Clin Exp Rheumatol 2016 Sep-Oct;34(6 Suppl 102):92-96. Epub 2016 Oct 11.
    Department of Internal Medicine, Division of Rheumatology, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey.
    Objectives: Haemoptysis occurring in a Behçet's syndrome (BS) patient with pulmonary artery involvement (PAI) during follow-up is usually regarded as PAI relapse. However, bronchial artery enlargement (BAE) may be the source of haemoptysis in some patients.

    Methods: A chart review at the end of December 2014 revealed 118 patients with PAI in our centre since 1979. Read More

    The association between the parenchymal neurological involvement and posterior uveitis in Behçet's syndrome.
    Clin Exp Rheumatol 2016 Sep-Oct;34(6 Suppl 102):82-85. Epub 2016 Oct 7.
    Department of Internal Medicine/Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey.
    Objectives: Behçet's syndrome (BS) is a systemic vasculitis, which may involve multiple organ systems simultaneously. Clinical findings in BS often fit into well-recognized patterns, such as the association between papulo-pustular skin lesions and arthritis. We have recently observed a distinct pattern, in which a subtype of neuro-Behçet's syndrome (NBS) is often preceded by specific ophthalmic manifestations of the disease process. Read More

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