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    1 OF 182

    Pulmonary complications of chemical pneumonia: a case report.
    Arch Argent Pediatr 2017 Aug;115(4):e245-e248
    Department of Pediatric Allergy, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
    Hydrocarbon aspiration (HA) can cause significant lung disease by inducing an inflammatory response, hemorrhagic exudative alveolitis, and loss of surfactant function. The most serious side effect of HA is aspiration pneumonia. Pneumothorax, pneumatocele, acute respiratory distress syndrome (ARDS), pulmonary abscess, bronchopleural fistula, bilateral hemorrhagic pleural effusion and pyopneumothorax were previously reported. Read More

    The Origins of Oral Medicine in the Hippocratic Collected Works.
    J Oral Pathol Med 2017 Jul 17. Epub 2017 Jul 17.
    Department of Oral and Maxillofacial Surgery, University Hospital of Heraklion, Heraklion, Greece.
    The collected works of Hippocrates describe for the first time in a systematic way a large number of oral diseases, such as ulcers, inflammations, abscesses and tumours from the epiglottis, mouth, tongue, palate, uvula and the sublingual area. Several of these case reports are remarkable for the accurate observation of clinical symptoms and signs, the aetiology, the pathogenesis and their therapeutic approach in relation to prognosis. The Hippocratic authors report cases of 'aphthae' as part of a polysystemic disease, described many centuries later by Behçet and Adamantiades, while they associate features of splenomegaly from endemic malaria with gingivitis ('ulitis'). Read More

    Imaging pearls of pediatric Behçet's disease.
    Eur J Radiol 2017 Jun 28. Epub 2017 Jun 28.
    Dr. Behçet Uz Children's Education and Research Hospital, Department Pediatric Radiology 35210, Konak, Izmir, Turkey. Electronic address:
    Objective: To emphasize the diverse diagnostic imaging findings of pediatric Behçet's disease and to define the fundamental imaging clues for pulmonary, vascular, gastrointestinal and central nervous system involvements of Behçet's disease in pediatric age group. We also aim to list the major imaging differences of Behçet's disease in childhood and adulthood.

    Conclusion: The diagnosis of pediatric Behçet's disease is challenging. Read More

    Role of N-acetyl galactosamine-4-SO4, a ligand of CD206 in HSV-induced mouse model of Behçet's disease.
    Eur J Pharmacol 2017 Jul 11. Epub 2017 Jul 11.
    Department of Microbiology, Ajou University School of Medicine, Suwon 443-380, Korea; Department of Biomedical Science, Ajou University School of Medicine, Suwon 443-380, Korea. Electronic address:
    CD206 is a macrophage mannose receptor involved in variety of autoimmune and inflammatory diseases. This study aimed to identify the pathogenic role of CD206 in a herpes simplex virus (HSV) induced Behçet's disease (BD) mouse model. CD206 positive cells were detected in peripheral blood mononuclear cells and quantified by flow cytometry. Read More

    [False aneurysm of the carotid artery revealing Behçet disease].
    J Med Vasc 2017 May 27;42(3):185-188. Epub 2017 Apr 27.
    Service de chirurgie vasculaire, CHU Ibn Sina, 165, rue Abdelkrim Khattabi, numéro 3, Souissi, Rabat, Maroc.
    Vascular involvement in Behçet's disease often present as venous thrombosis. Arterial damage is rare. We report a case of Behçet's disease occurring in a 40-year-old woman revealed by a false aneurysm of the left common carotid artery. Read More

    Unruptured multiple intracranial aneurysms associated with Behçet's disease.
    J Med Vasc 2017 Jul 27;42(4):234-236. Epub 2017 Jun 27.
    Service de médecine interne, centre hospitalier Pierre-le-Damany, 22300 Lannion, France.
    Behçet's disease is a systemic inflammatory disorder with a wide variety of cardiovascular complications. Intracranial aneurysm is extremely rare. Herein, we are presenting a 41-year-old male with Behçet's disease and a headache. Read More

    [Surgical and endoluminal management of the inflammatory aortitis: A Tunisian center experience].
    J Med Vasc 2017 Jul 2;42(4):213-220. Epub 2017 Jun 2.
    Service de chirurgie cardiovasculaire et thoracique, hôpital Habib Bourguiba, 3029 Sfax, Tunisie.
    Non-infectious aortitis is usually due to giant-cell arteritis, Takayasu disease or Behçet disease. The main aortic lesions are stenoses, occlusions and aneurysms in the Takayasu disease and aneurysms in the Behçet disease and giant-cell arteritis. Treatment is based on corticosteroid therapy and surgery. Read More

    Long-Term Efficacy of Pegylated Interferon Alpha-2b in Behçet's Uveitis: A Small Case Series.
    Ocul Immunol Inflamm 2017 Jul 12:1-8. Epub 2017 Jul 12.
    b Marmara University School of Medicine , Chief, Division of Rheumatology , Istanbul , Turkey.
    Purpose: To assess the long-term efficacy and safety of pegylated interferon alpha-2b (peg-IFN-α-2b) for severe uveitis associated with Behçet's disease.

    Methods: Peg-IFN-α-2b was administrated at an initial dosage of 0,5-1,5 µg/kg/week. If any complications were observed, the dosage was tapered. Read More

    Neuro-Behçet disease mimicking brain tumor: A case report.
    Surg Neurol Int 2017 5;8:97. Epub 2017 Jun 5.
    Neurosurgery Department, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
    Background: Behçet's disease (BD) is an inflammatory multisystem disease with unknown etiology, and consists of a TRIAD comprising recurrent oral ulcers, genital ulcers, and uveitis. In some cases, the disease affects the central nervous system, called Neuro-Behçet Disease (NBD). Few cases of NBD simulating a brain tumor have been previously reported. Read More

    Clinical significance of NCOA5 gene rs2903908 polymorphism in Behçet's disease.
    EXCLI J 2017 4;16:609-617. Epub 2017 May 4.
    Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biology, Tokat, Turkey.
    Behçet's disease (BD) is an autoimmune multisystemic disease. The precise etiology of BD is not fully understood; however, it is thought that interactions between genetic and environmental factors play an essential role in its pathogenesis. The nuclear receptor coactivator-5 (NCOA5) gene encodes a coregulator for nuclear receptor subfamily 1 group D member 2 (NR1D2) and estrogen receptor 1 and 2 (ESR1 and ESR2). Read More

    Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database.
    Eur J Paediatr Neurol 2017 Jun 29. Epub 2017 Jun 29.
    Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey.
    Objective: To document the clinical and paraclinical features of pediatric multiple sclerosis (MS) in Turkey.

    Methods: Data of MS patients with onset before age 18 years (n = 193) were collected from 27 pediatric neurology centers throughout Turkey. Earlier-onset (<12 years) and later-onset (≥12 years) groups were compared. Read More

    [Ocular Behçet].
    Pan Afr Med J 2017 25;26:237. Epub 2017 Apr 25.
    Service d'Ophtalmologie, Hôpital Militaire d'Instruction Mohamed V de Rabat, Maroc.
    Our study aimed to determine the clinical, therapeutic and prognostic features of ocular involvement in patients with Behçet's disease treated in our Department of ophthalmology. We conducted a retrospective data collection from medical records of 20 patients treated at the military hospital in Laayoune. All patients underwent complete ophthalmological examination and fluorescein angiography if necessary. Read More

    New imaging techniques in retinal vasculitis.
    Med Clin (Barc) 2017 Jul 4. Epub 2017 Jul 4.
    Institut Clínic d'Oftalmologia, Hospital Clínic de Barcelona, Barcelona, España.
    The term retinal vasculitis (RV) encompasses a heterogeneous group of sight-threatening conditions that are included in the intraocular inflammatory diseases that affect the posterior segment of the eye. Based on the nature of the inflammatory process, RV are classified into predominantly inflammatory or ischaemic (occlusive RV). The diagnosis is clinical and the aetiology can be infectious or non-infectious (immune-mediated). Read More

    Coexistence of multiple sclerosis and ankylosing spondylitis: Report of four cases from Russia and review of the literature.
    J Clin Neurosci 2017 Jul 3. Epub 2017 Jul 3.
    Bujanov Moscow City Clinical Hospital, Multiple Sclerosis Center № 1, Moscow, Russia.
    Multiple sclerosis is a chronic demyelinating disorder of the central nervous system. There are many cases of multiple sclerosis - like syndrome and demyelinating disorders in systemic lupus erythematosus, Sjogren disease, Behcet disease and other autoimmune conditions. Coexistence of ankylosing spondylitis and multiple sclerosis usually is rare but in this article we report 4 Russian patients with concomitant multiple sclerosis and ankylosing spondylitis diseases. Read More

    Behçet's disease with multiple splenic abscesses in a child.
    Intest Res 2017 Jul 12;15(3):422-428. Epub 2017 Jun 12.
    Department of Pediatrics, Gachon University Gil Hospital, Incheon, Korea.
    We report the case of a 5-year-old male patient with multiple aseptic splenic abscesses associated with Behçet's disease. The patient visited Gachon University Gil Hospital with fever, abdominal pain, and acute watery and bloody diarrhea, and reported a 2-year history of chronic abdominal pain and intermittent watery diarrhea. He was treated with antibiotics at a local clinic for fever and cervical lymph node swelling. Read More

    Long-term safety and efficacy of adalimumab for intestinal Behçet's disease in the open label study following a phase 3 clinical trial.
    Intest Res 2017 Jul 12;15(3):395-401. Epub 2017 Jun 12.
    Center for Advanced IBD Research and Treatment, Kitasato Institute Hospital, Kitasato University, Tokyo, Japan.
    Background/aims: Intestinal Behçet's disease (BD) is an immune-mediated inflammatory disorder. We followed up the patients and evaluated safety profile and effectiveness of adalimumab for the treatment of intestinal BD through 100 weeks rolled over from the 52 week clinical trial (NCT01243671).

    Methods: Patients initiated adalimumab therapy at 160 mg at week 0, followed by 80 mg at week 2, followed by 40 mg every other week until the end of the study. Read More

    Treatment and outcomes: medical and surgical treatment for intestinal Behçet's disease.
    Intest Res 2017 Jul 12;15(3):318-327. Epub 2017 Jun 12.
    The Third Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.
    Behçet's disease (BD) is a chronic relapsing disease involving multiple organ systems. BD is characterized clinically by oral and genital aphthae, cutaneous lesions, and ophthalmological, neurological, and/or gastrointestinal manifestations. It is widely recognized that the presence of intestinal lesions may be a poor prognostic factor in intestinal BD, increasing the risk of surgery and decreasing the quality of life. Read More

    Optimal diagnosis and disease activity monitoring of intestinal Behçet's disease.
    Intest Res 2017 Jul 12;15(3):311-317. Epub 2017 Jun 12.
    Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
    Intestinal Behçet's disease (BD), generally accepted as a type of inflammatory bowel disease (IBD), could be diagnosed when patients with BD have objectively documented gastrointestinal symptoms and intestinal ulcerations. Similar to IBD, intestinal BD has an unpredictable disease course with relapse and remission and is often related to a poor prognosis. However, there is no single gold standard for assessment of the disease activity of intestinal BD, and its diagnosis and management depend heavily on expert opinions. Read More

    Rediscover the clinical value of small intestinal bacterial overgrowth in patients with intestinal Behçet's disease.
    J Gastroenterol Hepatol 2017 Jun 30. Epub 2017 Jun 30.
    Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
    Background/Aims Many patients with intestinal Behçet's disease (BD) still suffer from gastrointestinal symptoms despite the disease being in endoscopic or radiological remission. Previous studies report that small intestinal bacterial overgrowth (SIBO) can be associated with inflammatory bowel disease. However, there have been no reports about SIBO in patients with intestinal BD. Read More

    Neuro-Behçet's disease in Peru: a case report and literature review.
    Medwave 2017 Jun 20;17(5):e6978. Epub 2017 Jun 20.
    Servicio de Neurología, Departamento de Medicina, Hospital Daniel Alcides Carrión, Callao, Perú; Unidad de Post Grado, Facultad de Medicina San Fernando, Universidad Nacional Mayor de San Marcos, Lima, Perú.
    Behçet's disease is a vasculitis that can cause inflammatory lesions in multiple organs or systems including the nervous system. Most cases worldwide have been reported along what is called the "Silk Route" from the Mediterranean region to Japan, so it is considered a rare disease in Latin American countries. The frequency of neurological involvement ranges from 5 to 13%. Read More

    Treatment of high-risk neuroblastoma: National protocol results of the Turkish Pediatric Oncology Group.
    J Cancer Res Ther 2017 Apr-Jun;13(2):284-290
    Department of Pediatric Oncology, Dokuz Eylul University Institute of Oncology, Izmir, Turkey.
    Background: The national protocol aimed to improve the outcome of the high risk neuroblastoma patients by high-dose chemotherapy and stem cell rescue with intensive multimodal therapy.

    Materials And Methods: After the 6 induction chemotherapy cycles, patients without disease progression were nonrandomly (by physicians' and/or parent's choices) allocated into two treatment arms, which were designed to continue the conventional chemotherapy (CCT), or myeloablative therapy with autologous stem cell rescue (ASCR).

    Results: Fifty-six percent (272 patients) of patients was evaluated as high risk. Read More

    Clinical presentations, metabolic abnormalities and end-organ complications in patients with familial partial lipodystrophy.
    Metabolism 2017 Jul 27;72:109-119. Epub 2017 Apr 27.
    Division of Endocrinology and Metabolism, Brehm Center for Diabetes Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
    Objective: Familial partial lipodystrophy (FPLD) is a rare genetic disorder characterized by partial lack of subcutaneous fat.

    Methods: This multicenter prospective observational study included data from 56 subjects with FPLD (18 independent Turkish families). Thirty healthy controls were enrolled for comparison. Read More

    Does atopy affect the course of viral pneumonia?
    Allergol Immunopathol (Madr) 2017 Jun 17. Epub 2017 Jun 17.
    Marmara University Faculty of Medicine, Department of Pediatric Pulmonology, Istanbul, Turkey.
    Background: The presence of atopy is considered as a risk factor for severe respiratory symptoms in children. The objective of this study was to examine the effect of atopy on the course of disease in children hospitalised with viral pneumonia.

    Methods: Children between the ages of 1 and 6 years hospitalised due to viral pneumonia between the years of 2013 and 2016 were included to this multicentre study. Read More

    Magnetic Resonance Enterography Findings of Intestinal Behçet Disease in a Child.
    Case Rep Radiol 2017 24;2017:8061648. Epub 2017 May 24.
    Section of Radiological Sciences, Department of Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Policlinico "G. Martino", Via Consolare Valeria 1, 98100 Messina, Italy.
    Behçet's disease (BD) is a multisystem disorder of unknown aetiology, characterized by recurrent oral ulcers, genital ulcers, uveitis, skin lesions, and pathergy. Gastrointestinal disease outside the oral cavity is well recognized and usually takes the form of small intestinal ulcers, with the most significant lesions frequently occurring in the ileocaecal region. Symptoms usually include nausea, vomiting, colicky abdominal pain, and change in bowel habit and it is not unusual that patients may present late, with life-threatening complications requiring surgery. Read More

    Metabolic control and periodontal treatment decreases elevated oxidative stress in the early phases of type 1 diabetes onset.
    Arch Oral Biol 2017 Jun 12;82:115-120. Epub 2017 Jun 12.
    Division of Periodontology, Malatya Oral and Dental Health Hospital, The Turkish Ministry of Health, Malatya, Turkey.
    Objective: Recently, increasing concern has been focused on the contribution of oxidative stress in the pathology of periodontal disease and diabetes mellitus. Firstly, the present study aimed to analyze gingival crevicular fluid (GCF), salivary, and serum oxidative status in children with type 1 diabetes mellitus (T1DM) at diagnosis and systemically healthy children with and without gingivitis. Additionally, the diabetic patients were reevaluated after diabetes and periodontal treatment. Read More

    Adherence to treatment in patients with Behcet's disease.
    Int J Rheum Dis 2017 Jun 19. Epub 2017 Jun 19.
    Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
    Aim: Behcet's disease (BD) is a chronic, inflammatory disease with multisystem involvement. Adherence to treatment is low in chronic diseases as well as inflammatory and autoimmune diseases. This study assessed factors associated with non-adherence to treatment in patients with BD. Read More

    Tuberculosis masked by immunodeficiency: a review of two cases diagnosed with chronic granulomatous disease.
    Tuberk Toraks 2017 Mar;65(1):56-59
    Clinic of Pediatric Immunology and Allergy, Dr. Behçet Uz Children Diseases Training and Research Hospital, Izmir, Turkey.
    Chronic granulomatous disease (CGD) is a genetically heterogeneous primary immunodeficiency that is characterized by recurrent and life-threatening infections resulting from defects in phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system and granuloma formation due to increased inflammatory response. The most commonly involved organs are the lungs, skin, lymph nodes, and liver due to infection. It may present with recurrent pneumonia, hilar lymphadenopathy, empyema, abscess, reticulonodular patterns, and granulomas due to lung involvement. Read More

    Evaluation of polyneuropathy and associated risk factors in children with type 1 diabetes mellitus.
    Turk J Med Sci 2017 Jun 12;47(3):942-946. Epub 2017 Jun 12.
    Department of Pediatric Neurology, Dr. Behçet Uz Children's Training and Research Hospital, İzmir, Turkey.
    Background/aim: Diabetes mellitus (DM) is one of the most common metabolic diseases seen in the world today. Diabetic neuropathy (DN) is a chronic complication of the disease that is rarely reported in children, since it has a relatively longer latency period. Our main objective in this study is to determine the incidence rate of DN in pediatric DM patients and assess the risk factors associated with DN. Read More

    Development and Improvement of Simple Colonic Mucosal Ulcer during Treatment of Severe Ulcerative Colitis with Tacrolimus.
    Case Rep Gastroenterol 2017 Jan-Apr;11(1):168-177. Epub 2017 Mar 21.
    Department of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
    Diarrhea, melena, and lower abdominal pain developed in a male in his 20s and colonoscopy showed pancolitis-type severe ulcerative colitis (UC). Treatment was initiated with 4,000 mg of 5-aminosalicylic acid and 60 mg/day of prednisolone, but the symptoms and inflammatory reaction worsened with prednisolone dose reduction. Tacrolimus was added to the treatment, which subsequently induced remission. Read More

    Assessment of Vascular Change Using Swept-Source Optical Coherence Tomography Angiography: A New Theory Explains Central Visual Loss in Behcet's Disease.
    J Ophthalmol 2017 9;2017:2180723. Epub 2017 May 9.
    King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
    Objective: To evaluate retinal vascular structural change in ocular Behcet's using optical coherence tomography angiography (OCTA) and fluorescein angiography (FA).

    Methods: An analytic cross-sectional study of 37 eyes of 21 Behcet's uveitic patients was performed. Foveal retinal thickness (FRT), perifoveal hypoperfusion areas in superficial capillary plexus (SCP), and deep capillary plexus (DCP) were measured with swept-source optical coherence tomography and OCTA. Read More

    Comparison of optical coherence tomographic findings between Behcet disease patients with and without ocular involvement and healthy subjects.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):69-73
    Department of Ophthalmology, School of Medicine, Cukurova University, Adana, Turkey.
    Purpose:: We aimed to compare the retinal nerve fiber layer, ganglion cell layer, inner plexiform layer, and the choroid thickness between patients with Behcet disease and healthy subjects by using spectral domain optical coherence tomography (SD-OCT).

    Methods:: Ninety eyes of 45 healthy subjects and 104 eyes of 52 patients with Behcet disease were included in this study. Rheumatoid factor and C-reactive protein levels were measured by blood testing in the patients. Read More

    A Patient with MSUD: Acute Management with Sodium Phenylacetate/Sodium Benzoate and Sodium Phenylbutyrate.
    Case Rep Pediatr 2017 15;2017:1045031. Epub 2017 May 15.
    Pediatric Metabolism Department, Ege University Medical Faculty, Izmir, Turkey.
    In treatment of metabolic imbalances caused by maple syrup urine disease (MSUD), peritoneal dialysis, and hemofiltration, pharmacological treatments for elimination of toxic metabolites can be used in addition to basic dietary modifications. Therapy with sodium phenylacetate/benzoate or sodium phenylbutyrate (NaPB) in urea-cycle disorder cases has been associated with a reduction in branched-chain amino acid (BCAA) concentrations when the patients are on adequate dietary protein intake. Moreover, NaPB in treatment of MSUD patients is also associated with reduction of BCAA levels in a limited number of cases. Read More

    Recent advances in childhood vasculitis.
    Curr Opin Rheumatol 2017 Jun 2. Epub 2017 Jun 2.
    aDepartment of Pediatric Rheumatology bInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.
    Purpose Of Review: The review aims to summarize the recent findings in vasculitis that may have an impact in our understanding or management of these diseases.

    Recent Findings: We are learning more about monogenic diseases that closely mimic the pediatric vasculitides. Deficiency of adenosine deaminase 2 can present with a polyarteritis nodosa (PAN)-like picture and should be included in the differential of all pediatric cases of PAN with a family history or in cases with early stroke, or in cases resistant to conventional therapy. Read More

    Impact of Neuro-Behçet Disease Immunoglobulin G on Neuronal Apoptosis.
    Noro Psikiyatr Ars 2017 Mar 8;54(1):67-71. Epub 2016 Dec 8.
    Department of Neuroscience, Aziz Sancar Institute of Experimental Medical Research, İstanbul University, İstanbul, Turkey.
    Introduction: Parenchymal neuro-Behçet disease (NBD) is encountered in 5%-15% of Behçet disease (BD) patients and is characterized by inflammation of the brainstem and diencephalon structures. Neuronal apoptosis has been shown to participate in neuronal cell loss. Anti-neuronal antibodies have been identified in NBD patients. Read More

    Potential metabolomic biomarkers for reliable diagnosis of Behcet's disease using gas chromatography/ time-of-flight-mass spectrometry.
    Joint Bone Spine 2017 May 24. Epub 2017 May 24.
    Division of Rheumatology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 06351 Seoul, Republic of Korea. Electronic address:
    Objectives: Although many diagnostic criteria of Behcet's disease (BD) have been developed and revised by experts, diagnosing BD is still complicated and challenging. No metabolomic studies on serum have been attempted to improve the diagnosis and to identify potential biomarkers of BD. The purposes of this study were to investigate distinctive metabolic changes in serum samples of BD patients and to identify metabolic candidate biomarkers for reliable diagnosis of BD using the metabolomics platform. Read More

    Neurological manifestations of Behçet's disease: Case report and literature review.
    Reumatol Clin 2017 May 22. Epub 2017 May 22.
    Servicio de Neurología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
    Neurological involvement in Behçet's disease is rare, especially at the onset. It can present in the form of parenchymal changes or as damage to the vascular structures in its nonparenchymal form. The coexistence of both kinds of manifestations in the same patient is exceptional. Read More

    Role of positron emission tomography for central nervous system involvement in systemic autoimmune diseases: status and perspectives.
    Curr Med Chem 2017 May 23. Epub 2017 May 23.
    Department of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro. Italy.
    In the last years, an increasing interest in molecular imaging has been raised by the extending potential of positron emission tomography (PET). The role of PET imaging, originally confined to the oncology setting, is continuously extending thanks to the development of novel radiopharmaceutical and to the implementation of hybrid imaging techniques, where PET scans are combined with computed tomography (CT) or magnetic resonance imaging(MRI) in order to improve spatial resolution. Early preclinical studies suggested that 18F-FDG PET can detect neuroinflammation; new developing radiopharmaceuticals targeting more specifically inflammation-related molecules are moving in this direction. Read More

    Serum PLR and LMR in Behçet's disease: Can they show the disease activity?
    Medicine (Baltimore) 2017 May;96(21):e6981
    aDepartment of Dermatology bDepartment of Surgery, First Hospital of Jilin University, Changchun, Jilin Province, China.
    The aim of this study is to determine platelet to lymphocyte ratio (PLR) and lymphocytes to monocytes ratio (LMR) levels in Behçet's disease (BD) and to investigate their relationships with disease activity.Hematological and inflammatory parameters including high-sensitivity C-reactive proteins (hs-CRP), erythrocyte sedimentation rate (ESR), PLR, and LMR were examined in BD and healthy controls.Data from 140 patients with BD (108 with active and 32 with inactive disease) and 107 controls were enrolled. Read More

    [Cardiac pseudotumor revealing Behçet's disease].
    Pan Afr Med J 2017 15;26:151. Epub 2017 Mar 15.
    Service de Chirurgie Cardiaque, Hôpital Militaire d'Instruction Mohamed V, Faculté de Médecine et de Pharmacie, Université Mohamed V, Rabat, Maroc.
    Intracardiac thrombosis is a rare complication of Behçet's disease (BD), which may manifest as intracardiac tumor. In half of cases, its detection precedes the diagnosis of MB. High mortality rates may be related to post-surgical complications and/or pulmonary arteries involvement. Read More

    High-dose intravenous steroid pulse therapy in ocular involvement of Behcet's disease: a pilot double-blind control study.
    Int J Rheum Dis 2017 May 19. Epub 2017 May 19.
    Behcet's Disease Unit, Rheumatology Research Center, Shariati Hospital, Tehran, Iran.
    Aim: To evaluate the efficacy of intravenous high-dose pulses of methylprednisolone (IVPM) for treatment of ocular involvement in Behcet's disease (BD).

    Method: In a double-blind control study, we randomized BD patients with posterior uveitis (PU) and/or retinal vasculitis (RV) into two groups. They received either IVPM (1000 mg methylprednisolone) or placebo for 3 consecutive days. Read More

    Infantile-onset thiamine responsive megaloblastic anemia syndrome with SLC19A2 mutation: a case report.
    Arch Argent Pediatr 2017 06;115(3):e153-e156
    Department of Pediatric Endocrinology, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
    Background: Thiamine-responsive megaloblastic anemia syndrome (TRMA), also known as Rogers syndrome, is characterized by megaloblastic anemia, sensorineural hearing loss, and diabetes mellitus. Disturbances of the thiamine transport into the cells results from homozygous or compound heterozygous mutations in the SLC19A2 gene.

    Case Presentation: We report a girl which presented with sensorineural deafness treated with a hearing prosthesis, insulin requiring diabetes, macrocytic anemia, treated with thiamine (100 mg/day). Read More

    Successful Treatment of Behçet's Disease Associated with Acute Myeloid Leukemia with Myelodysplasia-related Changes Using Azacitidine and Tacrolimus before Allogeneic Hematopoietic Stem Cell Transplantation.
    Intern Med 2017 15;56(10):1199-1202. Epub 2017 May 15.
    Third Department of Internal Medicine, Yamaguchi University School of Medicine, Japan.
    The coexistence of acute myeloid leukemia (AML) with Behçet's disease (BD) is rare. The optimum treatment for AML-associated BD has not been established. We herein report a patient with BD who developed AML with myelodysplasia-related changes. Read More

    Ustekinumab for Behçet's disease.
    J Autoimmun 2017 May 5. Epub 2017 May 5.
    Sorbonne Universités, UPMC Université Paris 06, UMR 7211, Département Hospitalo-Universitaire Inflammation-Immunopathologie-Biotherapie (DHU i2B), F-75005, Paris, France; INSERM, UMR_S 959, F-75013, Paris, France; CNRS, FRE3632, F-75005, Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Département de Médecine Interne et Immunologie Clinique, F-75013, Paris, France. Electronic address:
    Objective: To evaluate the efficacy and safety of ustekinumab in the treatment of oral ulcers (OU) in patients with Behçet's disease (BD).

    Patients And Methods: Prospective study including 14 patients [median age of 39 (34; 41) years, with 71% of men] fulfilling criteria of the International Study Group for BD and with active OU resistant to colchicine. Patients received ustekinumab 90 mg (n = 11) or 45 mg (n = 3) subcutaneously at inclusion, at week 4, and every 12 weeks. Read More

    [Clinical analysis of Behçet disease associated with pulmonary vascular disease].
    Zhonghua Jie He He Hu Xi Za Zhi 2017 May;40(5):343-348
    Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
    Objective: To investigate the clinical features, therapy and prognosis of Behcet's disease(BD) complicated with pulmonary vascular diseases (PVD). Methods: The clinical manifestation, hemodynamics, pulmonary artery angiographic findings, therapy and prognosis of PVD in BD in Shanghai Pulmonary Hospital from January 2009 to August 2016 were analyzed retrospectively. Results: Seven patients with average of (37±20) years were included. Read More

    Atrium Advanta V12 Large Diameter Stent-Graft Applications for Infrarenal Abdominal Aortic Pseudoaneurysms (due to Behcet Disease): Safety and Efficacy.
    Ann Vasc Surg 2017 May 4. Epub 2017 May 4.
    Department of Interventional Radiology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey. Electronic address:
    Background: The aim of the study was to determine the safety and effectiveness of Atrium Advanta V12 large diameter stent-graft applications for infrarenal abdominal aortic pseudoaneurysms (due to Behcet disease [BD]).

    Methods: Data of Advanta V12™ (Atrium Europe B.V, Mijdrecht, the Netherlands) applied 12 female patients (mean age 30. Read More

    Retrospective Study Evaluating Treatment Decisions and Outcomes of Childhood Uveitis Not Associated with Juvenile Idiopathic Arthritis.
    J Pediatr 2017 Jul 27;186:131-137.e1. Epub 2017 Apr 27.
    Pediatric Rheumatology, Centre de Référence des Maladies Auto-Inflammatoires, Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Sud University Hospital, Le Kremlin-Bicêtre, France.
    Objective: To evaluate treatment, ocular complications and outcomes of children with pediatric uveitis not associated with juvenile idiopathic arthritis.

    Study Design: This was a retrospective chart review of pediatric uveitis in children under 16 years of age, recruited from the pediatric rheumatology department at Bicêtre Hospital from 2005 to 2015. Patients with juvenile idiopathic arthritis-associated and infectious uveitis were excluded. Read More

    Evaluation of Optic Nerve with Strain and Shear Wave Elastography in Patients with Behçet's Disease and Healthy Subjects.
    Ultrasound Med Biol 2017 Jul 24;43(7):1348-1354. Epub 2017 Apr 24.
    Department of Ophtalmology, Faculty of Medicine, Kirikkale University, Yahsihan, Kirikkale, Turkey.
    The objective of this study was to investigate the elasticity characteristics of the optic nerve using strain and shear wave elastography in patients with Behçet's disease and to compare the results with those of healthy volunteers. Forty-six optic nerves from patients with Behçet's disease and 54 optic nerves from healthy volunteers were investigated prospectively in this study using strain and shear wave elastography. There was a statistically significant difference in terms of elasticity patterns between patients and healthy volunteers (p < 0. Read More

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