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    Comparison between optical coherence tomography angiography and fluorescein angiography findings in retinal vasculitis.
    Int J Retina Vitreous 2018 16;4:15. Epub 2018 Apr 16.
    1Departamento de Oftalmologia, Universidade Federal de São Paulo, Rua Botucatu, 821 - Vila Clementino, São Paulo, SP 04023-062 Brazil.
    Background: To describe optical coherence tomography angiography (OCT-A) findings in patients with retinal vasculitis and to compare them to current fluorescein angiography (FA) findings.

    Methods: This was an observational case series. Nineteen eyes in 10 patients with retinal vasculitis of various etiologies were imaged with FA (TRC-50DX, Topcon) and OCT-A (SD-OCT, Optovue). Read More
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    OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS IN PATIENTS WITH NONOCULAR BEHÇET DISEASE.
    Retina 2018 Apr 23. Epub 2018 Apr 23.
    Rheumatology, Faculty of Medicine, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt.
    Purpose: To describe the optical coherence tomography angiography findings in nonocular Behçet disease.

    Methods: The superficial capillary plexus (SCP) and deep capillary plexus (DCP) and outer retinal and choroidal flow were evaluated using optical coherence tomography angiography. Perimetry was performed to correlate any microvascular and functional changes. Read More
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    CSF/serum matrix metallopeptidase-9 ratio discriminates neuro Behçet from multiple sclerosis.
    Ann Clin Transl Neurol 2018 Apr 10;5(4):493-498. Epub 2018 Mar 10.
    Department of Neurosciences, Psychology, Drug and Child Health University of Florence Florence Italy.
    In neuro Behçet disease with multiple sclerosis-like features, diagnosis could be challenging. Here, we studied the cerebrospinal fluid and serum inflammatory profile of 11 neuro Behçet and 21 relapsing-remitting multiple sclerosis patients. Between the soluble factors analyzed (MMP9, TNF , IL6, CXCL13, CXCL10, CXCL8, IFN , IL10, IL17, IL23, and others) we found MMP9 increased in neuro Behçet serum compared to multiple sclerosis and decreased in cerebrospinal fluid. Read More
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    Adalimumab-based treatment versus DMARDs for venous thrombosis in Behçet syndrome. A retrospective study of 70 patients with vascular involvement.
    Arthritis Rheumatol 2018 Apr 20. Epub 2018 Apr 20.
    Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy.
    Objectives: Since Behçet syndrome (BS) is the prototype of inflammation-induced thrombosis, immunosuppressants are recommended in place of anticoagulants. Here we assessed the clinical efficacy and the corticosteroid-sparing effect of adalimumab (ADA)-based treatment versus DMARDs in a large retrospective cohort of patients with BS-related venous thrombosis.

    Methods: We retrospectively collected data from 70 BS patients treated with DMARDs or ADA-based regimens (ADA ± DMARDs) because of venous complications. Read More
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    Successful mesenchymal stem cell treatment of leg ulcers complicated by Behcet disease: A case report and literature review.
    Medicine (Baltimore) 2018 Apr;97(16):e0515
    Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
    Rationale: Behçet disease (BD) is a recurrent vasculitis characterized by oral and genital mucous membrane ulcers, uveitis, and skin lesions but only rarely leg ulcers. To our knowledge, no efficacious therapy has been described for BD patients with complicating, destructive leg ulcers.

    Patient Concerns: Here, We report the case of a 55-year-old woman with generalized erythema nodosum-like, papulopustular lesions, recurrent oral and genital ulcers accompanied with recurrent leg ulcers and trouble walking. Read More
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    Differential clinical presentation of Adamantiades-Behçet's disease in non-endemic and endemic areas: retrospective data from a Middle-European cohort study.
    Int J Rheum Dis 2018 Apr 17. Epub 2018 Apr 17.
    Department of Internal Medicine, Clinic II, Medizinische Universität Innsbruck, Innsbruck, Austria.
    Objectives: To assess demographical and clinical data in a Middle-European cohort of patients with Adamantiades-Behçet's disease (ABD), together with the use of medication in adherence to international guidelines.

    Methods: In a retrospective cohort study, in- and outpatients of an Austrian secondary and tertiary university hospital center were analyzed independent from the medical discipline involved. After ethics approval, screening for ABD-patients in the clinical information system resulted in 1821 documents from 1997 to 2016. Read More
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    Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis.
    J Formos Med Assoc 2018 Apr 10. Epub 2018 Apr 10.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed the frequencies of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 30 AG-positive RAS/BD (AGRAS/BD) and 33 AG-negative RAS/BD (AG־RAS/BD) patients.

    Methods: The frequencies of serum GPCA, TGA, and TMA positivities in 30 AGRAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects were calculated and compared. Read More
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    Behçet's disease: New insights into pathophysiology, clinical features and treatment options.
    Autoimmun Rev 2018 Apr 6. Epub 2018 Apr 6.
    Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00100 Rome, Italy. Electronic address:
    Behçet's disease (BD) is a rare systemic vasculitis characterized by oral aphthous ulcers, genital ulcers, ocular lesions and other systemic manifestations. BD occurs most frequently in Eurasian populations along the ancient trading route known as the "Silk Road" which extends from eastern Asia to the Mediterranean basin. The causes of BD are unknown: it is believed to be due to an autoimmune process triggered by an infectious or environmental agent in a genetically predisposed individual. Read More
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    Elevated expression of TSLP and IL-33 in Behçet's disease skin lesions: IL-37 alleviate inflammatory effect of TSLP.
    Clin Immunol 2018 Apr 6;192:14-19. Epub 2018 Apr 6.
    Université de Tunis El Manar, Faculty of Medicine of Tunis, Tunisia; Unit Research "12SP15": "Homeostasis and Cell Dysfuncyion", Tunisia. Electronic address:
    The release of TSLP and IL-33 affect the skin integrity, which unsettled transcription factor regulators. We investigate TSLP and IL-33 in Behçet disease (BD) and we prove the effect of the anti-inflammatory cytokine IL-37 in BD skin lesions on TSLP production. TSLP, IL-33 and GATA-3/T-bet, were measured using PCR in BD skin lesions. Read More
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    [Ocular manifestations in Behçet's disease].
    Rev Med Interne 2018 Apr 3. Epub 2018 Apr 3.
    Sorbonne universités, UPMC université Paris 06, UMR 7211, et DHU i2B-inflammation-immunopathologie-biothérapie, 75005 Paris, France; Inserm, UMR_S 959, 75013 Paris, France; CNRS, FRE3632, 75005 Paris, France; Département de médecine interne et d'immunologie clinique, université Pierre-et-Marie-Curie, groupe hospitalier Pitié-Salpêtrière, AP-HP, 75013 Paris, France; Centre national de référence des maladies auto-immunes systémiques rares, centre national de référence des maladies auto-inflammatoires et de l'amylose, France. Electronic address:
    Ocular disease in Behçet's disease is frequent and may be associated with a poor functional prognosis. Uveitis is the most common ocular manifestation in Behçet's disease and represents a diagnostic criterion of the disease. The ocular involvement is inaugural of the disease in 20% of the cases or may develop 2 to 3 years after the beginning of the extraocular signs. Read More
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    Cerebrospinal fluid IL-10 as an early stage discriminative marker between multiple sclerosis and neuro-Behçet disease.
    Cytokine 2018 Apr 3;108:160-167. Epub 2018 Apr 3.
    Institut Pasteur de Tunis, LTCII, LR11IPT02, Tunis 1002, Tunisia. Electronic address:
    Multiple Sclerosis (MS) and Neuro-Behçet's Disease (NBD) are two recurrent disorders affecting the central nervous system (CNS) by causing inflammation and irreversible damage. Inaugural clinical symptoms for both diseases might be very similar and definitive diagnosis could be delayed. The present study aimed to find out possible differences at early stages in the transcription factors/cytokines expression profiles in blood and cerebrospinal fluid (CSF) of MS and NBD patients which could be useful discriminative markers. Read More
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    Recurrent symptomatic ischemic stroke in a 46-year-old African male revealing Angio-Behçet with severe cardiovascular involvement.
    Egypt Heart J 2017 Mar 13;69(1):75-80. Epub 2016 Oct 13.
    Department of Cardiology and Internal Medicine, Military Hospital of Ouakam, Dakar, Senegal.
    Behçet'sdisease (BD) is a chronic, multisystem vasculitis. It is categorized under variable vessel vasculitis in the new Chapel Hill nomenclature as it involves blood vessels of any type and size. It is characterized by relapsing aphthous ulcers commonly occurring in the oral mucosa and genitalia with ocular involvement. Read More
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    Successful Optimization of Adalimumab Therapy in Refractory Uveitis Due to Behçet's Disease.
    Ophthalmology 2018 Mar 27. Epub 2018 Mar 27.
    Rheumatology and Ophthalmology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
    Purpose: To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Behçet disease (BD) who achieved remission after the use of this biologic agent.

    Design: Open-label multicenter study of ADA-treated patients with BD uveitis refractory to conventional immunosuppressants.

    Subjects: Sixty-five of 74 patients with uveitis due to BD, who achieved remission after a median ADA duration of 6 (range, 3-12) months. Read More
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    Influence of corticosteroid therapy on IL-18 and nitric oxide production during Behçet's disease.
    Inflammopharmacology 2018 Mar 29. Epub 2018 Mar 29.
    Universite des Sciences et de la Technologie Houari Boumediene, Algiers, Algeria.
    Background And Aims: Behçet's disease (BD) is a chronic multisystemic inflammatory disease with complex etiopathogenesis. Th1-proinflammatory cytokines seem to be involved in its pathogenesis. Our current study aims to evaluate interleukin-18 (IL-18) and nitric oxide (NO) involvement in the development of different clinical manifestations of BD as well as to investigate the corticosteroid therapy effect on this production in Algerian patients. Read More
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    Effectiveness and safety of Glycyrrhizae Decoction for Purging Stomach-Fire in Behcet disease patients: Study protocol for a randomized controlled and double-blinding trail.
    Medicine (Baltimore) 2018 Mar;97(13):e0265
    Department of Rheumatology and Immunology, Huadong Hospital affiliated with Fudan University, Shanghai, P.R. China.
    Background: Behcet disease (BD) is a worldwide-occurred autoimmune disorder and currently lack of optional successful treatment. An ancient traditional Chinese medical formula called Glycyrrhizae Decoction for Purging Stomach-Fire (GDPSF) was recorded and nowadays has been observed to be effective for BD patients. However, the strict randomized controlled and double-blinding trail is needed to further assess this alternative medicine. Read More
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    Herbal medicine for Behcet's disease: A protocol for a systematic review and meta-analysis.
    Medicine (Baltimore) 2018 Mar;97(13):e0165
    Clinical Research Division, Korea Institute of Oriental Medicine.
    Background: Herbal medicine treatment is often recommended in order to raise immunity levels and reduce the possibility of recurrence of symptoms, and treating the fundamental causes of the disease. This systematic review will assess the efficacy of herbal medicine in treating Behcet's disease.

    Methods And Analysis: We will search the following 11 electronic databases from their inception: PubMed, EMBASE, and CENTRAL; 3 Chinese databases (CNKI, Wanfang, and VIP); and 5 Korean databases (OASIS, DBpia, RISS, KISS, and KoreaMed). Read More
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    The ocular involvement did not accompany with the genital ulcer or the gastrointestinal symptoms at the early stage of Behçet's disease.
    Mod Rheumatol 2018 Mar 27:1-17. Epub 2018 Mar 27.
    a Department of Ophthalmology and Visual Science , Yokohama City University Graduate School of Medicine , Yokohama , Japan.
    Objective: This study aimed to identify patients with high-probability of ocular involvement of Behçet's disease (BD).

    Methods: The Japanese Ministry of Health, Labour and Welfare provided dataset of ongoing nationwide BD registration project. A patient who had confirmed BD and who was suspected to have BD were registered. Read More
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    Evaluation of efficacy of infliximab for retinal vasculitis and extraocular symptoms in Behçet disease.
    Jpn J Ophthalmol 2018 May 26;62(3):390-397. Epub 2018 Mar 26.
    Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
    Purpose: We evaluated ocular symptoms and activity of retinal vasculitis of Behçet disease before and after infliximab therapy, using Behçet disease ocular attack score 24 (BOS24) and fluorescein angiography (FA) score. We also analyzed the efficacy of infliximab for ocular and extraocular symptoms.

    Study Design: Retrospective study. Read More
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    Prolonged Tp-e Interval in Down Syndrome Patients with Congenitally Normal Hearts.
    Pediatr Int 2018 Mar 25. Epub 2018 Mar 25.
    Izmir Dr, Behcet Uz Children's Hospital, Department of Pediatric Cardiology, Izmir, Turkey.
    Background: Heterogeneity of ventricular repolarization has been assessed by using the QT dispersion in Down syndrome (DS) patients with congenitally normal hearts. However, novel repolarization indexes, the Tp-e interval and Tp-e/QT ratio, have not previously been evaluated in these patients. The aim of this study was to evaluate the Tp-e interval and Tp-e/QT ratio in DS patients without congenital heart defects. Read More
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    Hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in Behcet's disease patients with atrophic glossitis.
    J Formos Med Assoc 2018 Mar 20. Epub 2018 Mar 20.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed whether 30 AG-positive RAS/BD (AGRAS/BD) patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than 33 AG-negative RAS/BD (AG־RAS/BD) patients or 126 age- and sex-matched healthy control subjects.

    Methods: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations were measured and compared among 30 AGRAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects. Read More
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    Behcet disease combined with Sjogren syndrome: A unique case report and literature review.
    Medicine (Baltimore) 2018 Mar;97(12):e0138
    Department of Respiratory Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University.
    Rationale: Behcet disease(BD) and Sjogren syndrome(SS) are separate conditions that rarely concomitantly affect an individual. In theory,mild symptoms of patients with BD or SS are easy to igore and,thus,remain undiagnosed. There,it is reasonable to believe there may be some clinical cases of combined diseases that go undiscovered and which needs to be taken seriously. Read More
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    Intracardiac thrombosis in Behçet's Disease successfully treated with immunosuppressive agents: A case of vascular pathergy phenomenon.
    Intractable Rare Dis Res 2018 Feb;7(1):54-57
    Venous Thromboembolism Unit. Hospital General Universitario Gregorio Marañón, Madrid, Spain.
    Behçet's Disease (BD) is a rare multi-systemic inflammatory disorder classified as a systemic vasculitis of unknown aetiology. Vascular involvement occurs in approximately 5-51.6% cases, affecting venous and arterial vessels. Read More
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    Gastric parietal cell and thyroid autoantibodies in patients with Behcet's disease.
    J Formos Med Assoc 2018 Mar 14. Epub 2018 Mar 14.
    Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) were rarely examined in Behcet's disease (BD) patients. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in 63 BD patients.

    Methods: The frequencies of serum GPCA, TGA, and TMA positivities in 63 BD patients, 19 major-typed recurrent aphthous stomatitis (RAS)/BD (major RAS/BD) patients, 44 minor-typed RAS/BD (minor RAS/BD) patients, 520 RAS patients, and 126 healthy control subjects were calculated and compared. Read More
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    Can anticoagulation therapy in cerebral venous thrombosis associated with Behçet's disease be stopped without relapse?
    Rev Neurol (Paris) 2018 Mar 7;174(3):162-166. Epub 2018 Mar 7.
    Internal Medicine Department, Lariboisière Hospital, Paris VII University, 2 rue Ambroise Paré, 75475 Paris, France.
    There is as yet no consensus on the treatment of cerebral venous thrombosis (CVT) in Behçet's disease, and the place of anticoagulation is also still being debated. This report is of a series of seven patients with Behçet's disease (BD)-associated CVT, for which anticoagulation was stopped, and discusses the possibility of stopping anticoagulation during follow-up while receiving optimal treatment for BD. The diagnosis of BD was established during follow-up, which lasted a median of 120 [range: 60-1490] days after CVT diagnosis. Read More
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    Transcatheter embolotherapy of pulmonary artery aneurysms as emergency treatment of hemoptysis in Behcet patients: experience of a referral center and a review of the literature.
    Intern Emerg Med 2018 Mar 7. Epub 2018 Mar 7.
    Service de Radiologie, Hôpital Tenon, Hôpitaux Universitaires Est Parisien, Assistance Publique-Hôpitaux de Paris, Paris, France.
    Hemoptysis is a life-threatening complication of Behcet's disease that is likely related to pulmonary artery aneurysm (PAA). Vascular interventional radiology may offer effective emergency therapeutic option, but has not been thoroughly investigated in this setting. A case series of a French referral center for hemoptysis combined with a literature review of case reports was conducted. Read More
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    Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases.
    Rheumatol Ther 2018 Mar 7. Epub 2018 Mar 7.
    Division of Rheumatology and Clinical Immunology, University Hospital, Mainz, Germany.
    Since the discovery of HLA 60 years ago, it has contributed to the understanding of the immune system as well as of the pathogenesis of several diseases. Aside from its essential role in determining donor-recipient immune compatibility in organ transplantation, HLA genotyping is meanwhile performed routinely as part of the diagnostic work-up of certain autoimmune diseases. Considering the ability of HLA to influence thymic selection as well as peripheral anergy of T cells, its role in the pathogenesis of autoimmunity is understandable. Read More
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    Pediatricians' attitudes in management of acute otitis media and ear pain in Turkey.
    Int J Pediatr Otorhinolaryngol 2018 Apr 31;107:14-20. Epub 2018 Jan 31.
    Kırklareli State Hospital, Department of Pediatrics, Kırklareli, Turkey.
    Objectives: Acute otitis media (AOM) is predominantly a disease of childhood and one of the common reasons for prescribing antibiotics. Ear pain is the main symptom of AOM, with the result that parents frequently seek immediate medical assistance for their children. Antibiotic therapy for AOM does not provide symptomatic relief in the first 24 hours, and analgesics are commonly recommended for relieving the pain associated with AOM. Read More
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    Can mean platelet volume and neutrophil-to-lymphocyte ratio be biomarkers of acute exacerbation of bronchiectasis in children?
    Cent Eur J Immunol 2017 30;42(4):358-362. Epub 2017 Dec 30.
    Department of Pediatric Allergy and Immunology, Dr. Behcet Uz Children Disease and Surgery Training and Research Hospital, Izmir, Turkey.
    Introduction: Bronchiectasis (BE) is a parenchymal lung disease evolving as a result of recurrent lung infections and chronic inflammation. Although it has been shown in adult studies that mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) can be used as biomarkers of airway inflammation, knowledge is limited in the paediatric age group. The aim of our study is to investigate the potential of MPV and NLR as biomarkers that may indicate acute exacerbations of non-cystic fibrosis BE in children. Read More
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    Successful Treatment of Amyloid A-Type Amyloidosis Due to Behçet Disease With Tocilizumab.
    J Clin Rheumatol 2018 Feb 22. Epub 2018 Feb 22.
    Department of Internal Medicine Hacettepe University Faculty of Medicine Ankara, Turkey Division of Rheumatology Department of Internal Medicine Hacettepe University Faculty of Medicine Ankara, Turkey Department of Internal Medicine Hacettepe University Faculty of Medicine Ankara, Turkey Division of Rheumatology Department of Internal Medicine Hacettepe University Faculty of Medicine Ankara, Turkey.
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    Cavernous Transformation and Granulomatous Epididymis in Behçet Disease.
    J Clin Rheumatol 2018 Feb 22. Epub 2018 Feb 22.
    Department of Nephrology, Rheumatology Endocrinology and Metabolism Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences and Okayama University Medical School Okayama, Japan Department of Nephrology Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama, Japan
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    Interferon alpha-2a treatment for refractory Behcet uveitis in Korean patients.
    BMC Ophthalmol 2018 Feb 20;18(1):52. Epub 2018 Feb 20.
    Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodaemun-gu, Seoul, Republic of Korea.
    Background: To evaluate therapeutic outcomes of interferon alpha-2a (IFNα2a) treatment in patients with Behcet's disease who were refractory to immunosuppressive agents.

    Methods: This retrospective case series reviewed the medical records of 5 patients with refractory Behcet uveitis from January 2011 to February 2017. IFNα2a was administered at a dose of 3 million IU 3 times per week. Read More
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    A 25-Year-Old Male with Orogenital Ulcers, Rash, and Difficulty Swallowing.
    Dermatopathology (Basel) 2017 Jan-Dec;4(1-4):7-12. Epub 2017 Nov 8.
    Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
    A 25-year-old otherwise healthy male presented with new-onset odynophagia, rash, and orogenital ulcers. Despite treatment with antibiotics for presumed bacterial pharyngitis, the patient remained symptomatic, with abnormal vital signs and laboratory values. Upon dermatology consultation and histopathologic correlation, he was diagnosed with Behçet disease. Read More
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    Intrinsic changes of left ventricular function in patients with Behçet disease and comparison according to systemic disease activity.
    Echocardiography 2018 Feb 16. Epub 2018 Feb 16.
    Division of Cardiology, Department of Internal Medicine, School of Medicine, Chungnam National University, Chungnam National University Hospital, Daejeon, Korea.
    Purpose: Although cardiac manifestation of Behçet disease (BD) has been described in sporadic reports, its timely diagnosis remains difficult. The objective of this study was to describe early cardiac manifestations of BD. We also performed a comprehensive classification of systemic BD activity and compared their cardiac manifestations. Read More
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    Ulcerative colitis followed by the development of typical intestinal Behçet disease: A case report.
    Medicine (Baltimore) 2018 Feb;97(7):e9882
    Department of Gastroenterology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
    Rationale: Intestinal Behçet disease (intestinal BD) and inflammatory bowel disease (IBD) share a lot of characteristics, including genetic background, clinical manifestations, and therapeutic strategies, especially the extraintestinal manifestations, such as oral ulcers, arthralgia, eye lesions, skin lesions, etc, but the coexistence of these 2 diseases are uncommon. Behçet disease with gastrointestinal involvement in ulcerative colitis (UC) patient has been reported in just 1 previous case report, but, which can not be diagnosed as definite intestinal BD based on Korean novel diagnositic criteria due to lacking the typical ileocecal ulcer.

    Patient Concerns: We present a 23-year-old woman with ulcerative disease who developed typical intestinal BD, which is the first case report of patient with coexisting UC and typical intestinal BD. Read More
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    Evaluation of the effects of miRNAs in familial Mediterranean fever.
    Clin Rheumatol 2018 Feb 13. Epub 2018 Feb 13.
    Faculty of Medicine, Department of Medical Genetic, Ege University, Izmir, Turkey.
    Familial Mediterranean fever (FMF) is an inherited autoinflammatory disorder that can result in attacks with accompanying recurrent episodes of fever, serositis, and skin rash. MiRNAs are demonstrated to be associated with a number of other diseases; however, no comprehensive study has revealed its association with FMF disease. The aim is to investigate the role of microRNAs in FMF. Read More
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    Hughes-Stovin Syndrome as an Outcome of Behçet Disease or as a Different Entity.
    Korean J Thorac Cardiovasc Surg 2018 Feb 5;51(1):64-68. Epub 2018 Feb 5.
    Department of Cardiovascular Surgery, Kirikkale University Faculty of Medicine.
    Hughes-Stovin syndrome is a rare disorder of unknown etiology. Although the association between multiple pulmonary artery aneurysms and venous thrombosis of the lower limbs was reported by Beattie and Hall in 1911, it was not until 1962 that the eponym "Hughes-Stovin syndrome" was formally introduced in the medical literature. We describe 2 patients with Hughes-Stovin syndrome who presented with pulmonary artery aneurysm, thrombophlebitis, hemoptysis, and oral ulcers, review the manifestations of the disease, and compare its similarities with and differences from Behçet disease. Read More
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    How To Deal With Uveitis Patients?
    Curr Mol Med 2018 Mar;17(7):468-470
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China.
    During the past nine years, our center has grown into the largest uveitis referral center in China. To deal with this increasing stream of patients we have developed a management system to coordinate communication with our patients, their referring ophthalmologists, consultations with other medical specialties and worldrenowned foreign uveitis specialists. We have established the biggest database of uveitis patients records allowing continuous analysis of clinical features and response to treatment of patients with various uveitis entities as well as the evaluation of the relevance of various ancillary tests performed in this patient group. Read More
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    A nation-wide survey of patients with homozygous familial hypercholesterolemia phenotype undergoing LDL-apheresis in Turkey (A-HIT 1 registry).
    Atherosclerosis 2018 Mar 31;270:42-48. Epub 2018 Jan 31.
    Ankara University Medical Faculty Ibn-i Sina Hospital, Department of Hematology, Ankara, Turkey.
    Background And Aims: Homozygous familial hypercholesterolemia (HoFH) is a genetic condition characterized by lethally high levels of low-density lipoprotein cholesterol (LDL-C) from birth, and requires rapid and aggressive intervention to prevent death due to coronary heart disease and/or atherosclerosis. Where available, lipoprotein apheresis (LA) is the mainstay of treatment to promote survival.

    Methods: A-HIT1 registry was conducted with the aim of providing insight to the real-life management of HoFH patients undergoing LA in Turkey, where LA procedures are fully reimbursed and widely available. Read More
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    Surgical strategy for refractory aortitis.
    Gen Thorac Cardiovasc Surg 2018 Feb 5. Epub 2018 Feb 5.
    Department of Cardiovascular Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
    In some instances, we encounter cases suffered from inflammatory aortic diseases (aortitis) in Japan, some of which are at the active stages with systemic inflammation. Most of them are refractory with some technical difficulties of surgical treatment. The aortic wall, particularly, at the active stage, is too fragile to hold the surgical sutures. Read More
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    Frequencies of IL-15Rα+ cells in patients with Behçet's disease and the effects of overexpressing IL-15Rα+ on disease symptoms in mice.
    Cytokine 2018 Jan 27. Epub 2018 Jan 27.
    Department of Biomedical Science, Ajou University School of Medicine, Suwon 16499, Republic of Korea; Department of Microbiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea. Electronic address:
    It has been suggested higher serum levels of IL-15 and lower expression levels of IL-15 receptor alpha (IL-15Rα) are correlated with pathogenesis of Behçet's disease (BD). However, whether overexpressing IL-15Rα could be used as a therapeutic candidate for BD is currently unclear. Therefore, the purpose of this study was to determine whether overexpressing IL-15Rα could affect BD symptoms in a mouse model. Read More
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    Post-transplant malignancies in pediatric liver transplant recipients: Experience of two centers in Turkey.
    Turk J Gastroenterol 2018 01;29(1):87-91
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University School of Medicine, İzmir, Turkey.
    Background/aims: A liver transplant is the preferred treatment for patients with end-stage liver disease, as it usually results in longterm survival. However, due to the use of chronic immunosuppressive therapy, which is necessary to prevent rejection, de novo cancer is a major risk after transplantation. The aim of this study was to assess the incidence of post-transplant malignancies in children after liver transplantations. Read More
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    Infliximab associated with life-threatening lung infection in a patient with Behcet disease with intestinal and hematopoietic system involvement: A case report.
    Medicine (Baltimore) 2017 Dec;96(50):e9202
    Rheumatology and Immunology Department.
    Rationale: Tumor necrosis factor (TNF-α) participates in the pathophysiology of Behcet's disease (BD) and myelodysplastic syndrome (MDS). Infliximab is recommaned for the most severe type of BD, however, there is little evidence for its effectiveness in BD associated MDS.

    Patient Concerns: A 46-year-old female, initially diagnosed with intestinal BD and leukopenia was later diagnosed as MDS. Read More
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    [A case of chronic progressive neuro-Behcet's disease with cerebellar ataxia and bulbar palsy preceding mucocutaneo-ocular symptoms].
    Rinsho Shinkeigaku 2018 Feb 31;58(2):105-110. Epub 2018 Jan 31.
    Department of Neurology, National Hospital Organization Nagoya Medical Center.
    A 77-year-old man with a history of cigarette smoking had suffered from vertigo and depression repeatedly for twelve years. He gradually developed bradykinesia in the past half decade and fell down 3 times in the last half year. On admission, he presented with cerebellar ataxia and bulbar symptoms. Read More
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    Characteristic Echocardiographic Manifestations of Behçet's Disease.
    Ultrasound Med Biol 2018 Apr 17;44(4):825-830. Epub 2018 Jan 17.
    Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
    The objective of this study was to determine the characteristic echocardiographic manifestations of Behçet's disease. Ninety-seven Behçet's patients admitted to our hospital from January 2002 to December 2016 were retrospectively analyzed. There were 63 patients (64. Read More
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