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Curr Rheumatol Rep 2020 May 20;22(7):28. Epub 2020 May 20.

Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100, Ankara, Turkey.

Purpose Of The Review: Rheumatic diseases usually have very diverse and complex pathophysiology resulting in different clinical phenotypes. Some certain phenotypes cluster together with a common presentation, course, and outcome. Our primary aim is to review the known disease clusters in certain rheumatological conditions. Read More

Intern Med J 2020 May;50(5):642-643

Department of Immunology, Nepean Hospital, Sydney, New South Wales, Australia.

Cent Eur J Immunol 2020 ;45(1):69-72

Department of Pediatric Allergy and Immunology, Dr Behçet Uz Children's Hospital, Izmir, Turkey.

Introduction: Microdeletion syndromes may be accompanied by immunological disorders. This study aimed to evaluate the clinical and laboratory data as well as the immune functions of patients diagnosed with a microdeletion syndrome.

Material And Methods: 39 patients diagnosed with microdeletion syndrome who were monitored at the Pediatric Genetics and Immunology clinics at Dr. Read More

J Card Surg 2020 May 17. Epub 2020 May 17.

Division of Pediatric Cardiology, Columbia University Irving Medical Center, New York, New York.

Background: Pulmonary embolism and chronic thromboembolic pulmonary hypertension (CTEPH) are rare complications of Behcet's disease, especially in pediatric patients.

Aims/methods/results/conclusions: This case report highlights a presentation of CTEPH in an adolescent with Behcet's disease. A multidisciplinary approach was required for managing this patient's CTEPH, which successfully reversed the patient's pulmonary hypertension. Read More

Australas J Dermatol 2020 May 17. Epub 2020 May 17.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

JACC Cardiovasc Imaging 2020 May 14. Epub 2020 May 14.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

Turk J Gastroenterol 2020 Apr;31(4):324-330

Department of Pediatrics, Dr. Behcet Uz Children's Hospital, İzmir, Turkey.

Background/aims: We aimed to perform the validity and reliability analysis of the Turkish version of the Pediatric Nutritional Risk Score (PNRS).

Materials And Methods: The study group consisted of 149 patients aged between 1 month and 18 years who were admitted to the hospital for at least 48 h. The patients' age, gender, anthropometric measurements, length of stay, admission diagnosis, daily body weights, food consumption, and pain status were recorded. Read More

Drugs Today (Barc) 2020 May;56(5):303-310

Professor of Medicine (Rheumatology), Academic Hospital, Istanbul, Turkey.

Apremilast, an oral small molecule, is a phosphodiesterase 4 (PDE-4) blocker. It has been shown to be efficacious in managing psoriasis (PS) and psoriatic arthritis (PSA). In two controlled studies, it was also effective in controlling oral ulcers of Behçet syndrome (Bsy). Read More

J Clin Rheumatol 2020 May 9. Epub 2020 May 9.

From the Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea.

Exp Eye Res 2020 May 8;196:108045. Epub 2020 May 8.

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China. Electronic address:

The purpose of this study was to investigate whether single nucleotide polymorphisms (SNPs) of the tumor necrosis factor receptor superfamily (TNFRSF) and their ligand (TNFSF) gene are associated with susceptibility to Behcet's Disease (BD) in Chinese Han. A two-phase case-control study was performed in 1055 BD patients and 1829 healthy controls. A total of 27 SNPs was tested using MassARRAY iPLEX® technology. Read More

Intest Res 2020 May 12. Epub 2020 May 12.

First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

Behçet's disease (BD) is a multisystem inflammatory disease of unknown origin. Rarely, BD occurs together with myelodysplastic syndrome (MDS). Interestingly, it is speculated that these are not simple coexistence but that the etiology of intestinal BD is at least partly derived from MDS itself. Read More

Clin Neurophysiol 2020 Apr 4;131(7):1444-1452. Epub 2020 Apr 4.

Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, 34093 Capa, Istanbul, Turkey; Hulusi Behcet Life Sciences Research Laboratory - Neuroimaging Unit, Istanbul University, 34093 Capa-Istanbul, Turkey.

Objective: To investigate cognitive functions in non-demented patients with early-onset Parkinson's disease (PD), and to compare PARK2 gene mutation carriers and non-carriers by means of event-related brain potentials (ERPs).

Methods: The participants comprised patients with early-onset PD (EOPD) and healthy controls (HC). Patients with EOPD were divided into two groups as carriers of known pathogenic variants of PARK2 gene (EOPD-PC) and non-carriers of genes involved in familial PD (EOPD-NC). Read More

Ann Rheum Dis 2020 May 7. Epub 2020 May 7.

Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy.

Objective: To evaluate the effectiveness and safety of secukinumab in patients with a mucosal and articular Behçet's phenotype resistant to conventional and biologic treatment.

Methods: A multicentre retrospective study was performed on 15 patients with a mucosal and articular phenotype of Behçet's syndrome fulfilling the International Criteria for Behçet's Disease and refractory to treatment with colchicine, disease-modifying antirheumatic drugs and at least one antitumour necrosis factor-α agent. Minimum follow-up was set at 6 months. Read More

Isr Med Assoc J 2020 May;22(5):289-293

Shine Rheumatology Institute, Rambam Health Care Campus, Haifa, Israel affiliated with Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: Behçet's disease is a multi-systemic chronic relapsing inflammatory disease, classified among the vasculitides. The heterogeneity of clinical manifestations challenges the disease management.

Objectives: To assess efficacy and safety of adalimumab in patients with active persistent Behçet's arthritis who did not respond to disease-modifying anti-rheumatic drugs and to assess the impact of treatment on the cytokine milieu. Read More

Niger J Clin Pract 2020 May;23(5):680-685

Department of 1Dermatology, School of Medicine, Suleyman Demirel University, Isparta/, Turkey.

Background: Behcet's disease (BD) is a chronic, systemic inflammatory disease characterized with higher prevalence of psychiatric disorders, particularly major depression. This study aimed to determine the relationship between the psychological coping strategies with the disease and depression, anxiety, quality of life and disease activity in patients with BD.

Methods: Fifty Behcet's patients and 38 control subjects were compared by using Behcet's disease current activity form (BDCAF), quality of life instrument (QOL), structured clinical interview for DSM-IV axis I disorders (SCID-I), ways of coping questionnaire (WCQ), Beck depression inventory (BDI), and Beck anxiety inventory (BAI). Read More

DNA Cell Biol 2020 Apr 29. Epub 2020 Apr 29.

Rheumatology Institute of Lucania (IReL), San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza, Italy.

To investigate the association between a functional drug-response tumor necrosis factor (TNF)α gene polymorphism (at the positions of -308; rs1800629; NG_007462.1:g.4682G>A) and both disease susceptibility and clinical manifestations in a cohort of 130 Italian patients with Behçet syndrome (BS). Read More

Rheumatology (Oxford) 2020 May;59(Supplement_3):iii101-iii107

Department of Experimental and Clinical Medicine.

Behçet's syndrome (BS) is a systemic vasculitis characterized by a relapsing and remitting course. It can involve the skin, mucosa, joints, vessels (arteries and/or veins), eyes, and nervous and gastrointestinal systems, and so is referred to as a syndrome rather than as a unique and nosologically distinct condition. These involvements may present alone or co-exist in the same patient. Read More

Eur J Ophthalmol 2020 Apr 28:1120672120920214. Epub 2020 Apr 28.

Department of Ophthalmology, Ondokuz Mayis University, Samsun, Turkey.

Purpose: The aim of this study was to evaluate the quantitative measurements obtained by optical coherence tomography angiography in patients with Behçet uveitis.

Methods: A total of 22 consecutive patients with Behçet uveitis and 19 age-matched healthy individuals were included in the study. Quantitative analysis of optical coherence tomography angiography images was performed. Read More

J Clin Neurosci 2020 Apr 22. Epub 2020 Apr 22.

Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093, Capa-Istanbul, Turkey; Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, 34093, Capa-Istanbul, Turkey. Electronic address:

Mild Cognitive Impairment (MCI) is characterized by cognitive deficits that exceed age-related decline, but not interfering with daily living activities. Amnestic type of the disorder (aMCI) is known to have a high risk to progress to Alzheimer's Disease (AD), the most common type of dementia. Identification of very early structural changes in the brain related to the cognitive decline in MCI patients would further contribute to the understanding of the dementias. Read More

Rev Neurol (Paris) 2020 Apr 22. Epub 2020 Apr 22.

Laboratoire de recherche sur le diabète, Department of Internal Medicine, University Aboubek-Belkaid, Tlemcen, Algeria.

Introduction: Patients with cerebral venous thrombosis (CVT) often present with slowly progressive symptoms, leading to delay in diagnosis. The aim of our single-center study was to highlight the clinical patterns and etiological features of CVT, and to show the impact of diagnostic delay on prognosis in Algerian adults.

Methods: Retrospective and prospective data of patients with radiologically confirmed CVT were collected over a 10-year period at the neurovascular emergency unit of the Salim Zemirli hospital in Algiers. Read More

J Clin Med 2020 Apr 19;9(4). Epub 2020 Apr 19.

Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany.

Objectives: The aim of this systematic review was to assess the oral-health-related quality of life (OHRQoL) of adult patients with rheumatic diseases.

Material And Methods: A systematic literature search was performed, including clinical studies on adults (aged at least 18 years) with a verified diagnosis of rheumatic disease.

Results: 26 out of 41 clinical studies including rheumatoid arthritis (RA, seven studies), systemic sclerosis (SSc, five), Sjögren syndrome (SS, eight), Behcet disease (BD, four), systemic lupus erythematosus (SLE, one) and ankylosing spondylitis (AS, one) were found. Read More

J Vasc Surg 2020 Apr 20. Epub 2020 Apr 20.

Department of Vascular and Endovascular Surgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt. Electronic address:

Objectives: Endovascular treatment of peripheral arterial aneurysms (PAA) in patients with Behcet's Disease is controversial. We report a single institution experience of primary stent-graft repair of PAA in Behcet's patients.

Methods: Behcet's patients who had endovascular stent-graft repair of PAA at a single center between January 2012 and December 2018 were identified. Read More

Medicine (Baltimore) 2020 Apr;99(16):e19814

Rationale: Behçet Disease (BD) is a chronic inflammatory vasculitis with thrombogenicity and multisystem involvement. Deep vein thrombosis (DVT) in the lower extremities is the most frequent manifestation of vascular involvement in BD. The causes of thrombosis vary widely and include congenital predisposition and acquired factors, but of all the thrombosis, the cause is rarely BD. Read More

Dermatol Ther 2020 Apr 19:e13443. Epub 2020 Apr 19.

Department of Dermatology, Faculty of Medicine, Selcuk University, Konya, Turkey.

Behçet's disease (BD) is an autoimmune disease that affects many organs. We aimed to investigate the relationship between BD and these pregnancy-associated plasma protein A (PAPP-A), neopterin, and high sensitive C-reactive protein (hsCRP) parameters. The study included 57 BD patients and 54 healthy controls. Read More

Ocul Immunol Inflamm 2020 Apr 14:1-10. Epub 2020 Apr 14.

Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

: To develop an algorithm for the diagnosis of Behçet's disease (BD) uveitis based on ocular findings.: Following an initial survey among uveitis experts, we collected multi-center retrospective data on 211 patients with BD uveitis and 207 patients with other uveitides, and identified ocular findings with a high diagnostic odds ratio (DOR). Subsequently, we collected multi-center prospective data on 127 patients with BD uveitis and 322 controls and developed a diagnostic algorithm using Classification and Regression Tree (CART) analysis and expert opinion. Read More

J Oral Pathol Med 2020 Apr 13. Epub 2020 Apr 13.

Oral Medicine Section, Department of Surgical Sciences, CIR-Dental School, University of Turin, Turin, Italy.

Background: In oral medicine, colchicine is a therapeutic alternative for idiopathic recurrent aphthous stomatitis (RAS), Behçet disease (BD), periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome, and mouth and genitals ulcers with inflamed cartilage (MAGIC) syndrome. The present review aims to evaluate reliability of colchicine against recurrent oral ulcers.

Methods: A systematic review was conducted, with the following PICO (Patient, Intervention, Control, Outcome) question: "In populations with idiopathic or secondary recurrent oral ulcers, is colchicine more effective in improving pain and accelerating healing, compared to other intervention or placebo?"

Results: Seven RCTs and 3 OCTs were considered eligible. Read More

J Eur Acad Dermatol Venereol 2020 Apr 10. Epub 2020 Apr 10.

Department of Dermatology, Hospital de la Plana, Villareal, Castellón, Spain.

Secukinumab is a fully human anti-interleukin 17A monoclonal antibody widely used for moderate to severe psoriasis, with great efficiency and very infrequent adverse events. Nevertheless, we present two cases of Behçet Disease (BD) developed a few weeks after starting with secukinumab therapy for psoriasis. Read More

BMJ Case Rep 2020 Apr 8;13(4). Epub 2020 Apr 8.

Division of Rheumatology and Clinical Immunology, Jichi Medical University, Simotsuke, Tochigi, Japan.

We present the case of a patient whose skin findings and human leucocyte antigen (HLA) typing were key findings for the diagnosis of his neuro-Sweet disease. A 55-year-old Japanese man with skin rashes and high fever suddenly developed consciousness disturbance, and brain MRI showed encephalitis and leptomeningitis. Neuro-Behçet disease or microbial infection was initially suspected, but he was eventually diagnosed with neuro-Sweet disease based on his skin rashes and pathology and the presence of HLA-B54 and Cw1. Read More

Inflammopharmacology 2020 Mar 29. Epub 2020 Mar 29.

Cytokines and NO-Synthases, Laboratory of Cellular and Molecular Biology (LBCM), Faculty of Biological Science, USTHB, PB 32, 16111, Algiers, Algeria.

Background And Aims: Behçet's disease (BD) is an auto-immune vasculitis, characterized by episodic inflammation of multiple organs. The neutrophil to lymphocyte ratio (NLR) is used as a marker of inflammation in several diseases nowadays. While nitric oxide (NO) seem to be involved in BD pathogenicity. Read More

Turk J Med Sci 2020 Mar 28. Epub 2020 Mar 28.

Behcet's disease (BD) is a systemic and inflammatory disorder mainly present along the ancient Silk Road, from Mediterranean Sea to East Asia. A wide range of prevalence figures (0.1-420/100. Read More

Turk J Med Sci 2020 Mar 28. Epub 2020 Mar 28.

We still do not know the cause(s) of Behçet syndrome. Most probably several, separate disease mechanisms are involved. I like, some others, propose we call it not a disease but a syndrome, a construct with a list of strong and weak elements. Read More

Am J Ophthalmol Case Rep 2020 Jun 13;18:100660. Epub 2020 Mar 13.

Miyata Eye Hospital, Miyazaki, Japan.

Purpose: To report a case of uveitis with Behçet's disease in which serum levels of Krebs von den Lungen (KL)-6, a marker of interstitial lung disease, were elevated during treatment with adalimumab and returned to baseline after discontinuation of the agent.

Observations: A 67-year-old man complaining of vision disturbance was referred to our hospital. The patient had a history of recurrent episodes of bilateral uveitis and oral ulcers, and had been diagnosed with Behçet's disease. Read More

Intern Med 2020 Mar 26. Epub 2020 Mar 26.

Department of Radiology, The Jikei University School of Medicine, Japan.

Anticoagulation in venous thrombosis associated with Behçet disease (BD) is controversial. We herein report a 47-year-old woman with vessel thrombosis and pulmonary artery aneurysm (PAA) associated with BD who died of massive hemoptysis under oral anticoagulant. Although she was initially diagnosed with oral contraceptive-induced venous thromboembolism, a subsequent investigation led to a diagnosis of BD. Read More

Abdom Radiol (NY) 2020 Mar 25. Epub 2020 Mar 25.

Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Aim: To investigate the effects of cleansing Fleet's™ enema (FE) on rectal distention and image quality of diffusion-weighted imaging (DWI) in prostate magnetic resonance imaging (MRI).

Methods: This study included 117 prospectively accrued active surveillance patients who underwent prostate MRI both without (prep-) and with bowel preparation consisting of FE (prep+) obtained within 12 months of each other. The anterior-posterior (AP) diameter of the rectum, degree of perceived distention in the rectum and image quality scores were assessed by two independent readers for both (prep- and prep+) scans. Read More

Leuk Res Rep 2020 12;13:100196. Epub 2020 Mar 12.

Division of Hematology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan.

A relationship has been reported between myelodysplastic syndrome (MDS) and autoimmune disease. Behçet's disease is a multisystem inflammatory disorder with mucocutaneous, articular, gastrointestinal, neurological, and vascular manifestations. The co-occurrence of MDS with trisomy 8 and Behçet's-like disease was recently demonstrated. Read More

Front Immunol 2020 10;11:358. Epub 2020 Mar 10.

Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Non-infectious uveitis are intraocular inflammatory conditions caused by dysregulated activation of the immune response without any detectable infectious agents. The aim of this study was to explore potential markers and therapeutic targets for two distinct types of non-infectious uveitis associated with Behçet's disease (BD) and Vogt Koyanagi Harada (VKH) disease. Concentrations of 27 cytokines were investigated in aqueous humor (AH) samples from patients with active uveitis vs. Read More

Zhonghua Nei Ke Za Zhi 2020 Apr;59(4):303-308

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education,Peking Union Medical College Hospital Translational Medical Center, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, China.

To explore the efficacy and safety of anti-tumor necrosis factor alpha (TNFα) monoclonal antibodies (mAbs) for severe/refractory vasculo-Behcet's disease (BD). The clinical data of severe/refractory vasculo-BD patients treated with anti-TNFα mAbs were retrospectively analyzed. Response of anti TNFα mAbs was analyzed. Read More

Cardiovasc J Afr 2020 Jan/Feb;31(1):e1-e3

Cardiology Department, Cardiothrombosis Research Laboratory, University of Monastir and Fattouma Bourguiba University Hospital, Monastir, Tunisia. Email:

Behcet's disease is a chronic inflammatory syndrome that can affect arteries and veins of all sizes and is an unusual cause of myocardial infarction. We report a case of a 42-year-old male with no cardiovascular risk factors who was referred to our department for a spontaneously resolving anterior ST-elevation myocardial infarction. Clinical and biological investigations revealed a high probability for Behcet's disease. Read More

Zhonghua Yan Ke Za Zhi 2020 Mar;56(3):217-223

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China, is now working at the Department of Ophthalmology, the Fourth People's Hospital of Shenyang, Shenyang 110031, China.

To characterize the clinical features of patients with Behcet's uveitis. Retrospective case series study. Medical records of patients who were diagnosed as Behcet's uveitis in Peking Union Medical College Hospital between January 1998 and November 2015 were retrospectively reviewed. Read More

J Tradit Chin Med 2019 02;39(1):139-152

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Behcet's disease is a condition with a complicated and unclear etiology that comprises multi-systemic, chronic, inflammatory vasculitis. Behcet's disease can affect every tissue and organ in the body, and is characterized by recurrent oral and genital ulcers, ocular inflammation, skin lesions, and other manifestations. The incidence of Behcet's disease has a distinct regional specificity, and is most prevalent along the Silk Road, a route that stretched between the Mediterranean, Middle East and Far East. Read More

Turk J Haematol 2020 Mar 17. Epub 2020 Mar 17.

Department of Pediatric Hematology, Ankara City Hospital, Ankara, Turkey

Objective: Immune thrombocytopenia (ITP) is a rare autoimmune disease and hematologic disorder characterized by reduced platelet counts that can result in significant symptoms, such as bleeding, bruising, epistaxis or petechiae. The thrombopoietin receptor agonist, eltrombopag is second-line agents used to treat chronic immune thrombocytopenia purpura in adults and children.

Methods: The aim of the present study was to evaluate the efficacy, safety and side effects, especially iron deficiency of eltrombopag treatment in pediatric patients with acute refractory and chronic immune thrombocytopenia. Read More

Echocardiography 2020 Apr 16;37(4):646-648. Epub 2020 Mar 16.

Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Cardiac manifestations of hydatid cysts are rare and occur in 0.5% to 2% of all cases of human hydatidosis. Behçet's disease is a vasculitis which is often associated with venous thrombosis. Read More

Pediatr Crit Care Med 2020 May;21(5):e253-e258

Akdeniz University, Pediatric ICU, Pediatrics, Antalya, Turkey.

Objectives: To investigate conventional mechanical ventilation weaning characteristics of patients requiring conventional mechanical ventilation support for greater than 48 hours within the PICU.

Design: The prospective observational multicenter cohort study was conducted at 15 hospitals. Data were being collected from November 2013 to June 2014, with two designated researchers from each center responsible for follow-up and data entry. Read More

Clin Immunol 2020 May 10;214:108381. Epub 2020 Mar 10.

Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK. Electronic address:

Behçet's syndrome (BS) presents in childhood in up to 20% of reported cases. Diagnosis is clinical and multiple classification criteria have been developed. Presentation is heterogenous with recurrent oral ulceration often being the presenting feature. Read More

Am Fam Physician 2020 Mar;101(6):355-361

Georgetown University Medical Center, MedStar Georgetown University Hospital, Washington, DC, USA.

Genital ulcers may be located on the vagina, penis, and anorectal or perineal areas and may be infectious or noninfectious. Herpes simplex virus is the most common cause of genital ulcers in the United States. A diagnosis of genital herpes simplex virus infection is made through physical examination and observation of genital lesions. Read More

Mol Cell Proteomics 2020 May 11;19(5):871-883. Epub 2020 Mar 11.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Human leukocyte antigen (HLA) B*51:01 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly genetically associated with Behçet's disease (BD). Previous studies have defined two subgroups of HLA-B*51 peptidome containing proline (Pro) or alanine (Ala) at position 2 (P2). Little is known about the unconventional non-Pro/Ala2 HLA-B*51-bound peptides. Read More

BMJ 2020 Mar 11;368:m525. Epub 2020 Mar 11.

National Hospital Organization Tokyo Medical Center, Tokyo, Japan.

J Clin Res Pediatr Endocrinol 2020 Mar 11. Epub 2020 Mar 11.

Division of Pediatric Endocrinology, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey

Cytokine 2020 Mar 6;130:155054. Epub 2020 Mar 6.

Institut Pasteur de Tunis, LTCII, LR11IPT02, Tunis 1002, Tunisia; Faculty of Medicine of Tunis, 1006, Tunisia. Electronic address:

Treg-mediated immune suppression involves many molecular mechanisms including the cleavage of inflammatory extracellular ATP to adenosine by CD39 ectoenzyme. In the peripheral blood of Multiple Sclerosis (MS) patients, it has been suggested that CD39+ Treg cells have the potential to suppress pro-inflammatory IL-17 secreting cells. Herein, we studied cellular phenotype and mRNA expression of CD39 and CD73 ectoenzymes in the Cerebrospinal fluid (CSF) of MS patients and another neuro-inflammatory disease: the Neuro-behçet's disease (NBD). Read More

Zhonghua Nei Ke Za Zhi 2020 Mar;59(3):222-224

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To analyze the perceptions of cardiovascular specialists about Behcet's disease and its cardiovascular lesions in Beijing Anzhen Hospital, Capital Medical University. A survey using questionnaires was conducted among cardiovascular specialists in the hospital, the differences among groups were analyzed with χ(2) analyses. Less than half of the cardiovascular specialists were familiar with the diagnostic criteria of Behcet's disease (32. Read More