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    1 OF 183

    Surgical Removal of a Ruptured Radiculomedullary Artery Aneurysm: A Case Report.
    J Cerebrovasc Endovasc Neurosurg 2017 Sep 30;19(3):217-222. Epub 2017 Sep 30.
    Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, Korea.
    Subarachnoid hemorrhage due to a solitary spinal aneurysm is extremely rare, and diagnosis and treatment are challenging. We report a rare case of a ruptured radiculomedullary artery aneurysm in a patient with Behçet disease. A 49-year-old man presented with severe lower abdominal and leg pain. Read More

    Gastrointestinal Involvement in Behçet Disease.
    Rheum Dis Clin North Am 2018 Feb;44(1):45-64
    Division of Gastroenterology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Koca Mustafa Pasa Mahallesi, Cerrahpaşa Caddesi No:53, 34096 Fatih/Istanbul, Turkey. Electronic address:
    Behçet disease (BD) is a variable vessel vasculitis that can involve several organs and systems. Gastrointestinal (GI) involvement has an acute exacerbating course with ulcers, most commonly in the ileocolonic area. These ulcers can be large and deep, causing perforation and massive bleeding. Read More

    Macrophages from Behcet's Disease Patients Express Decreased Level of Aryl Hydrocarbon Receptor (AHR) mRNA.
    Iran J Allergy Asthma Immunol 2017 Oct;16(5):418-424
    Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, connecting environmental stimulators with the immune system. M1 macrophages are a part of immune system that contribute to the inflammatory events in the pathogenesis of Behcet's disease (BD). The effect of AHR on the macrophages in BD patients is still unclear. Read More

    Risk Factors and Outcomes of Emergency Room Visits in Intestinal Behçet's Disease.
    Digestion 2017 Nov 2;96(4):231-238. Epub 2017 Nov 2.
    Department of Internal Medicine, Seoul, Republic of Korea.
    Background/aims: Intestinal Behçet's disease (BD) is a chronic recurring intestinal vasculitic disorder that can lead to emergency room (ER) visits. We aimed to investigate the independent risk factors associated with intestinal BD-related ER visits.

    Methods: We retrospectively reviewed 606 patients with intestinal BD registered at the Inflammatory Bowel Disease Clinic of Severance Hospital, Seoul, Korea. Read More

    Recurrent Pulmonary Aneurysms: Hughes-Stovin Syndrome on the Spectrum of Behçet Disease.
    Chest 2017 Nov;152(5):e99-e103
    Division of Pulmonology, Department of Medicine, Tygerberg Academic Hospital/Stellenbosch University, Cape Town, South Africa.
    In this report, we describe a male patient who presented with recurrent life-threatening hemoptysis due to the sequential formation of multiple pulmonary aneurysms. Both pulmonary artery coil embolization and right lower lobectomy were performed, with limited success. The patient experienced extensive bilateral femoral DVT extending into the inferior vena cava, with massive hemoptysis, fulfilling the diagnosis of Hughes-Stovin syndrome. Read More

    Parenchymal neuro-Behçet disease with erectile dysfunction and micturition disturbances: case report and literature review.
    Rheumatol Int 2017 Nov 7. Epub 2017 Nov 7.
    Medical Faculty, Department of Rheumatology, Dokuz Eylul University, Izmir, Turkey.
    Parenchymal neuro-Behçet disease (NBD) is a serious clinic condition with a sub-acute or chronic disease course that results in incapability through pyramidal tract involvement. Though well-known consequences can deter a patient's life, both urinary symptoms and sexual dysfunction are underestimated complications of NBD and closely related in timing. Here, we report the case of a young male patient with parenchymal NBD who developed urinary incontinence and erectile dysfunction in addition to widespread pyramidal tract signs and symptoms. Read More

    Long-term follow-up of paediatric MEFV carriers.
    Clin Rheumatol 2017 Nov 3. Epub 2017 Nov 3.
    Department of Pediatric Rheumatology, Izmir Behçet Uz Children's Hospital, İsmet Kaptan Mah, Sezer Doğan Sok No:11, 35210, Konak, İzmir, Turkey.
    Although familial Mediterranean fever (FMF) is inherited autosomal recessively, some heterozygotes may express disease phenotype and require therapy. To date, there is no study in the literature about how to follow-up Mediterranean fever (MEFV) heterozygotes who do not fulfil FMF criteria in the paediatric age group. This study aims to share a single-centre experience of the long-term clinical and laboratory follow-up of paediatric MEFV carriers. Read More

    Rare esophageal ulcers related to Behçet disease: A case report.
    Medicine (Baltimore) 2017 Nov;96(44):e8469
    aDepartment of gastroenterology, Tianjin Hospital of Integrated Traditional Chinese and Western Medicine bDepartment of Spleen and Stomach, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospitial cDepartment of Diabetes, Tianjin Nankai District Hospital of traditional Chinese medicine, Tianjin, China.
    Rationale: The fundamental pathogenesis of Behçet disease (BD) is still unclear and controversial. Many cases of oral aphthous ulcers and genital ulcers related to BD are reported; nevertheless, idiopathic giant esophageal ulcers related to BD are rare. A rare case for esophageal ulcers related to BD is presented. Read More

    Analysis of pediatric dermatology inpatient consultations in a pediatric teaching hospital.
    Arch Argent Pediatr 2017 Dec;115(6):e377-e384
    Ataturk Research and Training Hospital, Department of Dermatology, Izmir, Turkey.
    Introduction: Although skin diseases are associated with low rate of hospitalization, dermatological manifestations are frequent in hospitalized patients. The aim of the study was to describe the inpatient dermatological consultations in a pediatric teaching hospital.

    Population And Methods: Recorded data from inpatient pediatric dermatology consultation requests on a total of 539 consecutive inpatients (aged 0-18 years) from January 2004 to April 2010 were analyzed for consult diagnosis, dermatological disease group, primary diagnosis, requesting department, diagnostic pattern, treatment modality and referral to another department. Read More

    A review of current management of vasculo-Behcet's.
    Curr Opin Rheumatol 2017 Oct 25. Epub 2017 Oct 25.
    aDivision of Rheumatology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon *Mira Merashli and Rozana El Eid equally contributed to this article.
    Purpose Of Review: To give an overview of recently published articles about the management of vasculo-Behcet's with particular emphasis on anticoagulation.

    Recent Findings: Biologic agents are emerging as a potential therapeutic option in refractory vasculo-Behcet with a good safety profile. Evidence further shows that following nonpulmonary aneurysm repair, there is a reduced risk of recurrent aneurysmal formation at the operative site in patients treated with immunosuppressants in addition to their surgery, than those undergoing surgical intervention alone. Read More

    Can neutrophil to lymphocyte ratio predict late-onset sepsis in preterm infants?
    J Clin Lab Anal 2017 Oct 21. Epub 2017 Oct 21.
    Department of Neonatology, Tepecik Training and Research Hospital, İzmir, Turkey.
    Background: The neutrophil to lymphocyte ratio (NLR) is an easily accessible biomarker that has been reported to represent disease severity in adult trials. The aim of this study was to evaluate the relationship between culture positiveness and NLR in cases where the reason of sepsis was considered, and to foresight an idea about the active agents.

    Methods: Preterm infants with birth weights ≤1500 g and/or ≤32 gestational weeks were eligible for this study. Read More

    Data of indirect immunofluorescence labeling of the mouse brain sections with sera from SLE and MS patients.
    Data Brief 2017 Dec 20;15:170-173. Epub 2017 Sep 20.
    Department of Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
    The data presented in this article are related to the research article entitled "Behcet Disease serum is immunoreactive to neurofilament medium which share common epitopes to bacterial HSP-65, a putative trigger" (Lule et a. 2017) [1]. The immunoreactivity to self-antigens is well characterized for systemic lupus erythematosus (SLE) and multiple sclerosis (MS) (Magro Checa et al. Read More

    Spectrum of orocutaneous disease associations: Genodermatoses and inflammatory conditions.
    J Am Acad Dermatol 2017 Nov;77(5):809-830
    Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:
    The oral cavity and cutaneous organ systems share a close embryologic origin. Therefore, there are numerous dermatologic conditions presenting with concomitant oral findings of which the dermatologist must be aware. The second article in this continuing medical education series reviews inflammatory orocutaneous conditions and a number of genodermatoses. Read More

    Clinical Heterogeneity and Phenotypic Expansion of NaPi-IIa-Associated Disease.
    J Clin Endocrinol Metab 2017 Sep 29. Epub 2017 Sep 29.
    Laboratory of Molecular Medicine, Rappaport Faculty of Medicine and Research Institute, Technion - Israel Institute of Technology, Haifa, Israel.
    Context: NaPi-IIa, encoded by SLC34A1 is a key phosphate transporter in the mammalian proximal tubule, and plays a cardinal role in renal phosphate handling. NaPi-IIa impairment has been linked to various overlapping clinical syndromes, including hypophosphatemic nephrolithiasis with osteoporosis, renal Fanconi's syndrome with chronic kidney disease, and most recently, with idiopathic infantile hypercalcemia and nephrocalcinosis.

    Objectives: We studied the molecular basis of idiopathic infantile hypercalcemia with partial proximal tubulopathy in two apparently unrelated patients of Israeli and Turkish descent. Read More

    Right ventricular thrombosis as a manifestation of Behçet's syndrome.
    ARYA Atheroscler 2017 Mar;13(2):91-94
    Assistant Professor, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Behçet's disease (BD) is a rare condition with a classic triad of oral and genital ulceration and eye disease. Cardiovascular complication is a rare finding in BD.

    Case Report: In this report, we present a seventeen years old patient with a history of fever for 20 days, who developed a clot in right ventricle (RV). Read More

    Clinical and imaging features of spinal cord type of neuro Behçet disease: A case report and systematic review.
    Medicine (Baltimore) 2017 Oct;96(40):e7958
    aDepartment of Neurology, the First Hospital of Hebei Medical University bBrain Ageing and Cognitive Neuroscience Laboratory of Hebei, Shijiazhuang, Hebei, China.
    Rational: To investigate the clinical and MRI characteristics of spinal cord nerve Behçet's disease.

    Patient Concerns: One patient with spinal cord nerve Behçet's disease was admitted to our hospital at October 20, 2015.

    Diagnose: Spinal cord nerve Behçet's disease. Read More

    CSF flow patterns in the brain in patients with neuro-Behçet disease and Behçet disease.
    Eur Rev Med Pharmacol Sci 2017 Oct;21(17):3906-3910
    Department of Radiology. Malatya Public Hospital, Malatya, Turkey.
    Objective: In the etiopathogenesis of Behcet disease (BD) and Neuro-Behcet disease (NBD), vascular eclipse occurs in both the arteries and veins. The disease affects all vascular structures. The present study evaluates the use of Phase Contrast (PC) Cerebral Spinal Fluid (CSF) Flow Magnetic Resonance Imaging (MRI), a non-invasive technique for measuring CSF dynamics, for determining the level of aqueducts that are influenced in BD and NBD. Read More

    Clinical manifestations of Behçet's disease depending on sex and age: results from Japanese nationwide registration.
    Rheumatology (Oxford) 2017 Nov;56(11):1918-1927
    Department of Ophthalmology and Visual Science.
    Objective: This report aimed to scrutinize the prevalence of Behçet's disease (BD)-related clinical manifestations based on age- and sex-specific subgroups using a Japanese nationwide registration database.

    Methods: The database of newly registered BD was obtained from the Japanese Ministry of Health, Labour and Welfare. Patients who met the International Criteria for Behçet's Disease were selected and analysed. Read More

    Thiopurine S-Methyltransferase Polymorphisms in Korean Dermatologic Patients.
    Ann Dermatol 2017 Oct 25;29(5):529-535. Epub 2017 Aug 25.
    Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
    Background: Thiopurine S-methyltransferase (TPMT) is an important enzyme in the metabolism of thiopurines including azathioprine (AZA), 6-mercaptopurine, and 6-thioguanine. TPMT genotyping is widely used for screening of AZA-related toxicity during routine clinical practice in Korea. However, the data of TPMT genotypes and its AZA-related toxicity have not been studied in the field of dermatology. Read More

    Cancer risk in patients with Behçet disease: A nationwide population-based dynamic cohort study from Korea.
    J Am Acad Dermatol 2017 Sep 25. Epub 2017 Sep 25.
    Department of Dermatology, Uijeongbu St. Mary's Hospital, Seoul, Republic of Korea. Electronic address:
    Background: Many studies have shown a link between inflammation and cancer development. However, there are few studies regarding the correlation between Behçet disease (BD) and cancer.

    Objectives: To determine the overall cancer risk and risk for specific cancers in patients with BD. Read More

    Behçet's disease: review with emphasis on dermatological aspects.
    An Bras Dermatol 2017 Jul-Aug;92(4):452-464
    Contact Dermatitis Outpatient Clinic - Dermatology Division at the Hospital das Clínicas - Universidade Federal de Minas Gerais (UFMG) - Belo Horizonte (MG), Brazil.
    Behçet's disease is a systemic vasculitis characterized by attacks of acute inflammation, which can affect almost every vascularized area of the body. There is a close correlation between the geographical distribution of HLA-B51 and its prevalence. In the etiopathogenesis there are indications of genetic susceptibility associated with environmental influence. Read More

    Beyond HLA Class I Antigens, HFE Mutations in Recurrent Aphthous Oral Ulcers and Behçet's Disease in The South of Tunisia.
    Med Princ Pract 2017 Sep 26. Epub 2017 Sep 26.
    To establish HLA class I and HFE mutation associations with recurrent aphthous oral ulcers (RAOU) and Behçet disease (BD) in a cohort of Southern Tunisian patients.
    Materials (Subjects) and Methods
    A total of 232 patients with RAOU and 123 healthy controls (HC) were enrolled in our study. Patients were divided into 2 groups based on the presence (BD+: 62) or not (BD-: 170). Read More

    Qualitative study: the experience and impact of living with Behcet's syndrome.
    N Z Med J 2017 Sep 22;130(1462):27-36. Epub 2017 Sep 22.
    Professor of Rheumatology, Department of Molecular Medicine and Pathology, University of Auckland, Auckland.
    Aim: Behcet's syndrome is a rare chronic multisystemic vasculitis of unknown aetiology, is unpredictable and can cause life-threatening complications. This qualitative study aims to explore the experiences of patients living with Behcet's syndrome in New Zealand.

    Methods: Eight English-speaking patients participated in in-depth semi-structured interviews about their experiences of living with Behcet's syndrome. Read More

    Oral mucosa biology and salivary biomarkers.
    Clin Dermatol 2017 Sep - Oct;35(5):477-483. Epub 2017 Jun 27.
    Department of Dermatology, University of California, Davis School of Medicine, Sacramento, CA. Electronic address:
    Although the surfaces of both the skin and oral mucosa are protected by squamous epithelial cells and fall within the scope of dermatologic practice, the oral cavity contains highly specialized structures and functions distinct from other skin biology and pathologic conditions and are also the purview of clinicians who care for patients with skin and mucosal diseases. We describe the distinct features of the tongue, mucosa, and salivary glands. In particular, we examine the composition and function of the saliva, with special focus on salivary biomarkers. Read More

    Behçet disease: New aspects.
    Clin Dermatol 2017 Sep - Oct;35(5):421-434. Epub 2017 Jun 27.
    Gazi University Faculty of Medicine, Department of Dermatology Emeritus Prof, Ankara, Turkey; Dermatology and Laser Center, Reduitstrasse 13, Landau, Germany. Electronic address:
    Behçet disease is currently considered an "autoinflammatory disease" triggered by infection and environmental factors in genetically predisposed individuals. Although the disease is characterized by recurrent oral and genital aphthous ulcers and ocular involvement, it can affect multiple organ systems. Complex aphthosis is characterized by recurrent oral and/or genital aphthous ulcers. Read More

    Choroidal thickness in non-ocular Behçet's disease - A spectral-domain OCT study.
    J Curr Ophthalmol 2017 Sep 26;29(3):210-213. Epub 2017 Jun 26.
    Doheny Eye Institute, Los Angeles, CA, USA.
    Purpose: To evaluate choroidal thickness in patients with non-ocular Behçet's disease (BD) using spectral domain optical coherence tomography (SD-OCT) and to compare the results to normal eyes.

    Methods: In this retrospective observational comparative study, we collected OCT and clinical data from the charts of 4 patients (7 eyes) with BD who had been referred for a screening eye exam and had a normal ocular examination. Data from 9 healthy volunteers (17 eyes) were collected as age-matched controls. Read More

    Intravitreal Adalimumab for the Control of Breakthrough Intraocular Inflammation.
    Ocul Immunol Inflamm 2017 Sep 14:1-6. Epub 2017 Sep 14.
    a Department of Ophthalmology , American University of Beirut , Beirut , Lebanon.
    Purpose: Investigate the efficacy of intravitreal adalimumab in breakthrough panuveitis in patients on systemic adalimumab for more than 3 months.

    Methods: Retrospective study of patients on systemic adalimumab with breakthrough panuveitis requiring intravitreal adalimumab therapy.

    Results: Seven eyes of four patients with Adamantiades-Behçet disease panuveitis were included and all were maintained on systemic adalimumab for 7. Read More

    Long-term efficacy and safety of the interleukin-1 inhibitors anakinra and canakinumab in refractory Behçet disease uveitis and concomitant bladder papillary carcinoma.
    Intern Med J 2017 Sep;47(9):1086-1088
    Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.

    Ocular Behcet's disease is associated with aberrant methylation of interferon regulatory factor 8 (IRF8) in monocyte-derived dendritic cells.
    Oncotarget 2017 Aug 19;8(31):51277-51287. Epub 2017 Apr 19.
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China.
    Aberrant methylation of interferon regulatory factor 8 (IRF8) has been noted in various tumors. IRF8 has also been reported to be involved in many autoimmune diseases, including Behcet's disease (BD). However, the methylation status of IRF8 in BD has not been reported. Read More

    A Case Report of 9p Deletion Syndrome Associated with Partial Trisomy of 1q42.
    Maedica (Buchar) 2017 Jan;12(1):55-58
    Professor of Neurogenetics, Department of Medical Genetics, Motahrai Hospital, Urmia University of Medical Sciences, Iran.
    We report a case of partial deletion of 9p with partial trisomy of 1q42 syndrome, which is a rare clinical and cytogenetic report. The dysmorphic features of the patient include microcephaly, plagiocephaly, trigonocephaly with metopic ridge, arched eyebrows, hypertelorism, down-slanting palpebral fissure, ptosis, blepharophimosis, unilateral left epicanthic fold, long eyelashes, low-set and posteriorly rotated ears, long philtrum, anteverted nares, retrognathia and unilateral undescended testis. Chromosomal analysis revealed partial monosomy of 9p24 associated with partial trisomy of 1q42q>ter. Read More

    Olfactory Dysfunction Associated With Neuro-Behçet Disease.
    J Craniofac Surg 2017 Oct;28(7):e707-e710
    *Department of Otorhinolaryngology, Bezmiâlem Vakif University, Medical Faculty, Fatih †Department of Otorhinolaryngology, Acibadem University, Maslak Hospital ‡Department of Otorhinolaryngology, Gaziosmanpasa Taksim Research and Education Hospital §Department of Neurology, Istanbul Medipol University, Istanbul, Turkey.
    Introduction: Neurologic involvement associated with Behçet disease (BD) is defined as a different entity: Neuro-Behçet disease (NBD). Behçet disease presents with olfactory dysfunction. It is not known whether this is the consequence of mucosal involvement or neurologic involvement. Read More

    Behçet's syndrome: providing integrated care.
    J Multidiscip Healthc 2017 14;10:309-319. Epub 2017 Aug 14.
    Division of Rheumatology, Department of Internal Medicine.
    Behçet's syndrome (BS) is a multisystem vasculitis that presents with a variety of mucocutaneous manifestations such as oral and genital ulcers, papulopustular lesions and erythema nodosum as well as ocular, vascular, gastrointestinal and nervous system involvement. Although it occurs worldwide, it is especially prevalent in the Far East and around the Mediterranean Sea. Male gender and younger age at disease onset are associated with a more severe disease course. Read More

    Distinct clinical features between acute and chronic progressive parenchymal neuro-Behçet disease: meta-analysis.
    Sci Rep 2017 Aug 31;7(1):10196. Epub 2017 Aug 31.
    Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
    Neuro-Behçet's disease (NBD) is subcategorized into parenchymal-NBD (P-NBD) and non-parenchymal-NBD types. Recently, P-NBD has been further subdivided into acute P-NBD (A-P-NBD) and chronic progressive P-NBD (CP-P-NBD). Although an increasing number of studies have reported the various clinical features of A-P-NBD and CP-P-NBD over the last two decades, there was a considerable inconsistency. Read More

    Behçet Disease serum is immunoreactive to neurofilament medium which share common epitopes to bacterial HSP-65, a putative trigger.
    J Autoimmun 2017 Nov 24;84:87-96. Epub 2017 Aug 24.
    Institute of Neurological Sciences and Psychiatry, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Department of Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address:
    Autoimmune and dysimmune inflammatory mechanisms on a genetically susceptible background are implicated in the etiology of Behçet's Disease (BD). Heat-shock protein-65 (HSP-65) derived from Streptococcus sanguinis was proposed as a triggering factor based on its homology with human HSP-60. However, none of the autoantigens identified so far in sera from BD share common epitopes with bacterial HSP-65 or has a high prevalence. Read More

    Cerebral pseudo-tumoral neuro-Behcet: Histological demonstration of an inflammatory and vascular disease.
    Clin Neurol Neurosurg 2017 Oct 12;161:48-50. Epub 2017 Aug 12.
    Internal Medicine Department, French Reference Centre for Rare Autoimmune Systemic Diseases, e3 m Institute, Assistance-Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France; Paris VI University (UPMC), Sorbonnes Universités, Paris, France.

    Behçet disease: a rare systemic vasculitis in Poland.
    Pol Arch Intern Med 2017 Oct 23;127(10):652-656. Epub 2017 Aug 23.
    INTRODUCTION    Behçet disease (BD) is an immune‑mediated small‑vessel systemic vasculitis, which is rarely seen in Poland. OBJECTIVES    The aim of this study was to evaluate the incidence and prevalence of BD, as well as to assess the sex and geographical distribution of BD in Poland during a 7‑year follow-up. To our knowledge, this is the first evaluation of this rare disease in Poland, based on a hospital morbidity database. Read More

    Mutational profile of rare variants in inflammasome-related genes in Behçet disease: A Next Generation Sequencing approach.
    Sci Rep 2017 Aug 16;7(1):8453. Epub 2017 Aug 16.
    Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), Sevilla, 41013, Spain.
    Behçet's disease (BD) is an immune-mediated systemic disorder with a well-established association with HLA class I and other genes. BD has clinical overlap with many autoinflammatory diseases (AIDs). The aim of this study was to investigate the role of rare variants in seven genes involved in AIDs: CECR1, MEFV, MVK, NLRP3, NOD2, PSTPIP1 and TNFRSF1A using a next generation sequencing (NGS) approach in 355 BD patients. Read More

    Interleukin-26 is overexpressed in Behçet's disease and enhances Th17 related -cytokines.
    Immunol Lett 2017 Oct 12;190:177-184. Epub 2017 Aug 12.
    Unit Research 12SP15 "Expression moléculaire des interactions cellulaires et leur mode de communication dans le poumon profond", A. Mami Hospital, Ariana, Tunisia; Université de Tunis El Manar, Faculty of Medicine of Tunis, Department of Basic Sciences, Tunis, Tunisia; Division of Pulmonology, Department of Paediatric Respiratory Diseases, Abderrahman Mami Hospital, Pavillon B, Ariana, Tunisia.
    Behçet's disease (BD) is a multi-systemic inflammatory disorder characterized by the "triple symptom complex". Several pro-inflammatory cytokines, mainly derived from the immune Th17 axis, seem to be involved in different pathogenic pathways leading to development of the clinical manifestations. Here, we have analyzed the expression and role of IL-26 in active BD patients, an inflammatory disorder characterized by bronchoalveolar lavage fluid (BAL) and cerebrospinal fluid (CSF) inflammation. Read More

    The association between P selectin glycoprotein ligand 1 gene variable number of tandem repeats polymorphism and risk of thrombosis in Behçet's disease.
    Int J Rheum Dis 2017 Aug 14. Epub 2017 Aug 14.
    Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
    Objectives: Behçet's disease (BD) has been recognized as an unclassified type of vasculitis with an accompanying tendency to thrombosis. No disease-specific pathology has been demonstrated so far to explain the prothrombotic state, and this predisposition is considered to be associated with endothelial activation/dysfunction. P-selectin glycoprotein ligand-1 (PSGL-1) variable number of tandem repeat (VNTR) polymorphism has an impact on the protein length, and heterozygosity affect of the PSGL-1 to P-selectin interaction, which has been found to be associated with an increased risk of thrombosis in patients with antiphospholipid syndrome. Read More

    Increased Arterial Stiffness in Behçet's Disease: a Systematic Review and Meta-Analysis.
    Korean Circ J 2017 Jul 27;47(4):477-482. Epub 2017 Jul 27.
    Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA.
    Background And Objectives: Behçet's disease (BD) is a systemic vasculitis that is characterized by genital, oral, or skin lesions, uveitis, and vascular complications. Studies have shown that increased arterial stiffness is common in systemic immune and inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus. However, current research has not yet determined whether patients with BD have increased arterial stiffness. Read More

    Myelopathy in Behçet's disease: The Bagel Sign.
    Ann Neurol 2017 Aug 10;82(2):288-298. Epub 2017 Aug 10.
    Mayo Clinic College of Medicine, Department of Neurology, Rochester, MN.
    Objective: To describe the clinical and distinctive imaging features of myelopathy associated with Behçet's disease (BD).

    Methods: We evaluated the records of patients meeting the following criteria: (1) fulfillment of the International Study Group criteria for BD; (2) clinically suggestive of myelopathy; (3) simultaneous spinal cord and brain magnetic resonance images (MRIs) within 1 month of acute worsening of myelopathy; and (4) follow-up duration ≥ 1 year after initial MRI evaluation. Patients not fulfilling all inclusion criteria and having MRIs with poor quality or missing sequences were excluded. Read More

    Efficacy of cataract surgery in patients with uveitis: A STROBE-compliant article.
    Medicine (Baltimore) 2017 Jul;96(30):e7353
    aDepartment of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University bKey Laboratory of Myopia, Ministry of Health cShanghai Key Laboratory of Visual Impairment and Restoration of Shanghai, Fudan University, Shanghai, China.
    To evaluate the visual outcomes of cataract surgery in patients with uveitis, and to determine risk factors for the recurrence of uveitis and postoperative complications.Eighty patients with uveitis who underwent phacoemulsification with intraocular lens (IOL) implantation were included in this retrospective study. We analyzed the following data: patient characteristics, medications used, visual acuity, and complications of cataract surgery. Read More

    Pulmonary complications of chemical pneumonia: a case report.
    Arch Argent Pediatr 2017 Aug;115(4):e245-e248
    Department of Pediatric Allergy, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
    Hydrocarbon aspiration (HA) can cause significant lung disease by inducing an inflammatory response, hemorrhagic exudative alveolitis, and loss of surfactant function. The most serious side effect of HA is aspiration pneumonia. Pneumothorax, pneumatocele, acute respiratory distress syndrome (ARDS), pulmonary abscess, bronchopleural fistula, bilateral hemorrhagic pleural effusion and pyopneumothorax were previously reported. Read More

    The origins of oral medicine in the Hippocratic collected works.
    J Oral Pathol Med 2017 Oct 9;46(9):689-694. Epub 2017 Aug 9.
    Department of Oral and Maxillofacial Surgery, University Hospital of Heraklion, Heraklion, Greece.
    The collected works of Hippocrates describe for the first time in a systematic way a large number of oral diseases, such as ulcers, inflammations, abscesses and tumours from the epiglottis, mouth, tongue, palate, uvula and the sublingual area. Several of these case reports are remarkable for the accurate observation of clinical symptoms and signs, the aetiology, the pathogenesis and their therapeutic approach in relation to prognosis. The Hippocratic authors report cases of aphthae as part of a polysystemic disease, described many centuries later by Behçet and Adamantiades, while they associate features of splenomegaly from endemic malaria with gingivitis (ulitis). Read More

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