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Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1434-1435

A 33-year-old man presented with recurrent oral ulcers for more than 10 years,accompanying dyspnea and dysphagia for 1 year and aggravate for 1 month.Physical examination:pharyngeal cavity stenosis,mucous retention, epiglottis was extruded into the infant type. Electronic laryngoscope:Epiglottis curl,bilateral pyriform sinus disappeared. Read More

Eur Cytokine Netw 2018 Sep;29(3):95-102

USTHB, "Cytokines and NO Synthases" team, LBCM, FSB, BP 32, El Alia, 16111, Bab ezzouar, Algiers, Algeria.

Behçet's disease is a multisystem disease. It stands at the crossroad between the autoimmunity and auto-inflammatory disorders. In this study, we sought to address a relationship that might exist between interleukin-1β (IL-1β) and the oxidants/antioxidants markers in Behçet's patients. Read More

Childs Nerv Syst 2018 Dec 11. Epub 2018 Dec 11.

School of Medicine, Department of Neonatology, Celal Bayar University, Manisa, Turkey.

Purpose: Kyphosis is the most severe spinal deformity associated with meningomyelocele (MMC) and is seen in approximately 15% of neonates. Our purpose is to present our clinical experience, to discuss the technique and deformity correction in kyphectomy in neonates with MMC, and to assess its long-term outcomes.

Method: In this prospective study, the authors reviewed eight cases submitted to surgery between 2013 and 2015. Read More

Arthritis Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurosciences, Psychology, Pharmacology and Child Health (NEUROFARBA), University of Firenze, Italy.

In our work entitled "Adalimumab-based treatment versus DMARDs for venous thrombosis in Behçet syndrome. A retrospective study of 70 patients with vascular involvement" , we showed that Adalimumab (ADA)-based regimen is more effective and rapid than disease modifying anti-rheumatic drugs (DMARDs) in inducing resolution of venous thrombosis in patients with Behçet syndrome (BS), also allowing significant reduction of steroid exposure. This article is protected by copyright. Read More

PLoS One 2018 11;13(12):e0208254. Epub 2018 Dec 11.

Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: This study investigated the association of central macular thickness (CMT) and macular volume (MV) with severity of Behçet uveitis in the absence of macular edema (ME).

Methods: This retrospective, interventional study included a total 131 treatment-naïve Behçet patients with varying degree of uveitis in the absence of ME. The mean CMT and MV were obtained by spectral domain optical coherence tomography (SD ODT). Read More

Best Pract Res Clin Rheumatol 2018 04 21;32(2):261-270. Epub 2018 Sep 21.

Izmir, Turkey. Electronic address:

Behçet's disease (BD) may be regarded as a polygenic autoinflammatory disease although adaptive immune system has also been implicated in pathogenesis. Different classification criteria sets exist for BD, including the new "International Criteria for BD." The pooled prevalence of BD was calculated as 10. Read More

Scand J Immunol 2018 Dec 1:e12737. Epub 2018 Dec 1.

Ege University, Faculty of Medicine, Department of Pediatric Immunology, Izmir, Turkey.

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by susceptibility to bacterial and fungal infections resulting from the inadequacy of phagocytic leukocytes to produce reactive oxygen radicals. CGD is a genetically heterogeneous disease with an X-linked recessive (XR-CGD) form caused by mutations in the CYBB (OMIM #300481) gene encoding the gp91(phox) protein, and an autosomal recessive (AR-CGD) form caused by mutations in the CYBA (OMIM #608508), NCF1 (OMIM #608512), NCF2 (OMIM #608515) and NCF4 (OMIM #601488) genes encoding p22(phox), p47(phox), p67(phox), and p40(phox), respectively. The genetic mutation of one of the cytosolic p47phox/p67phox proteins and membrane-bound gp91phox/p22phox proteins, which constitutes the NADPH oxidase enzyme complex, causes the disease. Read More

Intern Emerg Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Dermatology, School of Medicine, Marmara University, Istanbul, Turkey.

This study aims to assess the relationship between illness perception and disease course and symptoms in Behçet disease (BD). One hundred ten consecutive BD patients (F/M 50/60, mean age 38.5 ± 9. Read More

Am J Infect Control 2018 Nov 27. Epub 2018 Nov 27.

Division of Pediatric Infectious Disease, Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.

Background: Central line-associated bloodstream infection is the most common infection associated with health care in preterm infants. The purpose of this 18-month cross-sectional study was to evaluate the effectiveness of bundle applications in the prevention of umbilical venous catheter (UVC)-associated bloodstream infections.

Methods: This study included patients in whom UVCs were inserted and who were diagnosed with central line-associated bloodstream infection between July 1, 2016, and December 31, 2017, according to the Centers for Disease Control and Prevention criteria. Read More

Molecules 2018 Nov 29;23(12). Epub 2018 Nov 29.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.

With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (⁻) were synthesized and characterized. Due to thione-thiol tautomerism in the intermediate compound , type of substitution reaction in the final step was determined by two-dimensional (2D) NMR. In vitro antifungal activity of the synthesized compounds was evaluated against eight species. Read More

Turk J Pediatr 2018 ;60(3):229-237

Departments of Medical Biology and Genetics, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.

Öncü-Öner T, Ünalp A, Porsuk-Doru İ, Ağılkaya S, Güleryüz H, Saraç A, Ergüner B, Yüksel B, Hız-Kurul S, Cingöz S. GPR56 homozygous nonsense mutation p.R271* associated with phenotypic variability in bilateral frontoparietal polymicrogyria. Read More

J Immunol 2018 Dec 3. Epub 2018 Dec 3.

Department of Human Genetics, Genentech, Inc., South San Francisco, CA 94080.

Both common and rare genetic variants of laccase domain-containing 1 (, previously C13orf31) are associated with inflammatory bowel disease, leprosy, Behcet disease, and systemic juvenile idiopathic arthritis. However, the functional relevance of these variants is unclear. In this study, we use LACC1-deficient mice to gain insight into the role of LACC1 in regulating inflammation. Read More

Intern Emerg Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy.

Behçet's syndrome (BS) is a complex vasculitis, characterised by peculiar histological, pathogenetic and clinical features. Superficial venous thrombosis (SVT) and deep vein thrombosis (DVT) are the most frequent vascular involvements, affecting altogether 15-40% of BS patients. Atypical thrombosis is also an important clinical feature of BS, involving the vascular districts of the inferior and superior vena cava, suprahepatic veins with Budd-Chiari syndrome, portal vein, cerebral sinuses and right ventricle. Read More

Eur J Paediatr Neurol 2018 Nov 20. Epub 2018 Nov 20.

Dokuz Eylul University, Division of Pediatric Metabolism and Nutrition, Izmir, Turkey. Electronic address:

Purpose: Ketogenic diet (KD) is an effective non-pharmacological treatment for drug-resistant epilepsy. The aim of this study was to investigate the efficacy, tolerability and complications of olive oil-based KD in epileptic children.

Method: In this single-center, prospective study, patients were followed up at 1, 3, 6 and 12 months after KD initiation. Read More

J Cancer Res Ther 2018 Oct-Dec;14(6):1184-1190

Department of Medical Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Introduction: The relation between Behçet's disease (BD) and breast cancer (BC) is unclear. Our purpose is to investigate whether BD has an important effect on BC or vice versa.

Patients And Methods: A total of 12 female BC patients with a diagnosis of BD were identified from a cohort including 5050 BC patients. Read More

Blood Cells Mol Dis 2018 Aug 10. Epub 2018 Aug 10.

Ege University Medical Faculty, Pediatric Metabolism Department, İzmir, Turkey.

Gaucher Disease (GD) is the most common lysosomal storage disorder has traditionally been classified into three clinical phenotypes. Type 3 GD is characterized by neurological involvement but neurological symptoms generally appear later in life than in type 2 disease. Neutropenia is much rarer than other hematological manifestations in GD and has not been scrutinized adequately. Read More

Clin Exp Immunol 2018 Nov 25. Epub 2018 Nov 25.

Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Firenze, Italy.

Behçet's syndrome (BS) is a complex disease with different organ involvement. The vascular one is the most intriguing considering the existence of a specific group of patients suffering from recurrent vascular events involving the venous and, more rarely, the arterial vessels. There are several clinical clues suggesting the inflammatory nature of thrombosis in BS, especially of the venous involvement, thus BS is considered a model of inflammation-induced thrombosis. Read More

Avicenna J Phytomed 2018 Nov-Dec;8(6):498-503

Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Objective: (NS) is a herbal medicine with anti-inflammatory and anti-oxidant functions. This study was designed to evaluate the effect of oral administration of NS seeds oil on the treatment of Behcet's disease (BD).

Materials And Methods: In this double-blind randomized controlled study, 130 patients with BD were screened and 71 patients with BD were randomly allocated to the treatment (n=37) and control (n=34) groups. Read More

Open Access Maced J Med Sci 2018 Oct 3;6(10):1871-1874. Epub 2018 Oct 3.

University Clinical Center of Kosovo, Clinic of Dermatology, Prishtina, Kosovo.

Background: Behçet's syndrome is associated with inflammation of various areas of the body. Sy. Behcet is a rare, chronic, recurrent disease characterised by changes in the: Arteries that supply blood to the body's tissues, veins that take the blood back to the lungs, the back of the eye's retina, brain, joints, skin and bowels. Read More

Immunol Lett 2018 Nov 14. Epub 2018 Nov 14.

Connective Tissue Research Center, Tabriz University of Medical Science, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Objective: Behçet's disease (BD) is a chronic multi-factorial inflammatory disease with the important role of genetic in activation of its inflammatory response. Interleukin (IL)-33 is a member of the IL-1 family of cytokines that affects innate and adaptive immune systems to promote inflammatory responses. In the current study, we investigated the association of IL-33 gene rs1342326 polymorphism and expression levels of this gene in peripheral blood mononuclear cells (PBMCs) with the susceptibility to BD in Azari population of Iran. Read More

Front Immunol 2018 30;9:2463. Epub 2018 Oct 30.

Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.

Four inflammatory diseases are strongly associated with Major Histocompatibility Complex class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A29:02), ankylosing spondylitis (HLA-B27), Behçet's disease (HLA-B51), and psoriasis (HLA-C06:02). The endoplasmic reticulum aminopeptidases (ERAP) 1 and 2 are also risk factors for these diseases. Since both enzymes are involved in the final processing steps of MHC-I ligands it is reasonable to assume that MHC-I-bound peptides play a significant pathogenetic role. Read More

Pediatr Neurol 2018 Dec 10;89:3-10. Epub 2018 Aug 10.

Department of Pediatric Genetics, Dokuz Eylül University Medical School, Izmir, Turkey.

The neurocutaneous syndromes are a group of multisystem disorders that affect the skin and central nervous system. Neurofibromatosis 1, neurofibromatosis 2, tuberous sclerosis complex, and Sturge-Weber syndrome are the four major neurocutaneous disorders that mainly present in childhood. In this review, we discuss the clinical findings and genetic diagnosis, related genes/pathways and genotype-phenotype correlations of these four neurocutaneous syndromes. Read More

Rheumatol Int 2018 Nov 12. Epub 2018 Nov 12.

University Hospital Marques of Valdecilla, Santander, Spain.

The aim of this study is to compare the efficacy and safety of biological therapy with cyclosporin A (CsA), azathioprine (AZA), or placebo in uveitis flares and other ocular outcomes in patients with Behçet disease. A comprehensive and sensitive search in MEDLINE, EMBASE, and the Cochrane Library was performed. We selected articles including: (1) adult patients with Behçet's and uveitis; (2) on biological therapies; (3) placebo or active control with CsA or AZA; (4) analyzing efficacy (number of uveitis flares, macular edema, etc. Read More

Mult Scler Relat Disord 2018 Nov 1;27:203-205. Epub 2018 Nov 1.

Department of Neurology, Cliniques Universitaires St-Luc, Université catholique de Louvain (UCLouvain), 10 avenue Hippocrate, 1200 Brussels, Belgium. Electronic address:

RMD Open 2018 17;4(2):e000740. Epub 2018 Oct 17.

Institute of Biotechnology, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.

Objectives: encodes A20 that negatively regulates nuclear factor kappa light chain enhancer of activated B cells (NF-κB), the major transcription factor coordinating inflammatory gene expression. polymorphisms have been linked with a spectrum of inflammatory and autoimmune diseases and, recently, loss-of-function mutations in A20 were found to cause a novel inflammatory disease 'haploinsufficiency of A20' (HA20). Here we describe a family with HA20 caused by a novel loss-of-function mutation and elucidate the upstream molecular mechanisms linking HA20 to dysregulation of NF-κB and the related inflammasome pathway. Read More

Int J Rheum Dis 2018 Nov 5. Epub 2018 Nov 5.

Division of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey.

Gan To Kagaku Ryoho 2018 Oct;45(10):1536-1538

Dept. of Surgery, Yokohama City University.

A 32-year-old woman with a history of undergoing upper gastrointestinal surgery was administered prednisolone for abortive Behçet's disease since 2015. In March 2017, upper gastrointestinal endoscopy revealed a 0-IIc type early stage gastric carcinoma at the posterior wall of the gastric antrum. The pathological diagnosis was signet-ring cell carcinoma. Read More

Turk J Gastroenterol 2018 11;29(6):650-654

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Dr. Behçet Uz Children Hospital, İzmir, Turkey.

Background/aims: Thiopurines are widely used in the treatment of inflammatory bowel disease, but data are limited. Or aim was to determine the outcome of thiopurine application in children diagnosed with ulcerative colitis (UC).

Materials And Methods: Forty-eight patients with UC, diagnosed at our center between 2005 and 2016 and applied azathiopurine (AZA), were included in the study. Read More

Pan Afr Med J 2018 11;30:106. Epub 2018 Jun 11.

Hôpital Militaire d'Instruction Mohammed V, Service de Médecine Interne, Rabat, Maroc.

We here report the case of a 55-year old patient, with a history of recurrent buccal aphthosis, hospitalized for pelvic pain of sudden onset. Clinical examination showed sensitive pulsatile pelvic mass with blowing sound suggesting vascular origin. Examination of external genitalia showed scrotal scar after healing of aphthous ulcers. Read More

J Ocul Pharmacol Ther 2018 Oct 25. Epub 2018 Oct 25.

2 Department of Internal Medicine, Division of Rheumatology, Marmara University School of Medicine , Istanbul, Turkey .

Purpose: To investigate factors affecting relapse and remission in patients with Behçet uveitis (BU) in the context of using the interferon alpha2a (IFNα2a) therapy.

Methods: Clinical records were reviewed of 32 patients (totaling 54 eyes) presenting with severe BU who had been treated with IFNα2a therapy. Factors influencing relapsing-remitting course of BU during IFNα2a therapy and after the cessation of the agent were evaluated. Read More

Turk J Haematol 2018 Oct 16. Epub 2018 Oct 16.

Department of Pediatric Oncology, Dokuz Eylül University, Institute of Oncology.

Asian J Psychiatr 2018 Oct 9. Epub 2018 Oct 9.

Adnan Menderes University, Department of Psychiatry, Aydin, Turkey. Electronic address:

Front Immunol 2018 25;9:2157. Epub 2018 Sep 25.

Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Behçet disease (BD) is an inflammatory systemic disease with a fluctuating course, which can affect the skin, eyes, central nervous system, musculoskeletal, gastrointestinal, and vascular systems. No laboratory tests are currently available for the diagnosis of BD and monitoring disease activity. Moreover there is a lack of knowledge on BD pathogenesis. Read More

J Pak Med Assoc 2018 Jul;68(7):1148-1150

Department of Dermatology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Pyoderma gangrenosum (PG) of the penis is a very rare entity in medicine and it can be destructive. Generally, pyoderma gangrenosum is known to be common among patients with systemic diseases such as inflammatory bowel diseases, polyarthritis, diverticulosis, paraproteinaemia, myeloma, leukaemia, active chronic hepatitis, and Behcet syndrome. Early diagnosis and administrating effective treatment can prevent permanent damage to the penis and save the patient's social life. Read More

Eur J Haematol 2018 Oct 9. Epub 2018 Oct 9.

Erciyes University Medical Faculty, Kayseri, Turkey.

Objectives: To evaluate the long-term efficacy and safety of deferasirox therapy in a large observational cohort of children with transfusion-dependent thalassemia (TDT) and sickle cell anemia (SCA) in Turkey.

Methods: This was a multicenter, prospective cohort study including TDT and SCA patients aged 2-18 years with iron overload (≥100 mL/kg of pRBC or a serum ferritin [SF] level >1000 μg/L) receiving deferasirox. Patients were followed for up to 3 years according to standard practice. Read More

Reumatol Clin 2018 Oct 5. Epub 2018 Oct 5.

Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas (UEAS), Hospital Universitario Central de Asturias, Oviedo, Asturias, España.

IgG4-related disease is characterized by a lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis and obliterative phlebitis. It can present as parotid gland enlargement, tubulointerstitial nephritis, retroperitoneal fibrosis or pancreatitis, although nearly any organ can be affected. We report the case of a 37-year-old woman who presented with severe dysphonia and recurrent painful aphthous ulcers, with histopathological findings at the level of the larynx that revealed a lymphoplasmacytic infiltrate and IgG4 positivity. Read More

Eur J Ophthalmol 2018 Oct 7:1120672118803534. Epub 2018 Oct 7.

1 Advanced Eye Centre, Department of Ophthalmology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

A 19-year-old Nepalese male presented with complaints of bilateral ocular discomfort, photophobia, watering, and redness for 1 week. Visual acuity was 6/12 and 6/60 in the right and left eye, respectively. On biomicroscopic examination, presence of peripheral stromal infiltrates with conjunctival follicles was noted; infiltrates progressed to involve central cornea with further decrease in vision over next few days. Read More

Taiwan J Ophthalmol 2018 Jul-Sep;8(3):168-172

Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan.

We report a young male patient with Behçet's disease who suffered from sight-threatening recurrences under treatment with azathioprine, cyclosporine, and prednisolone. His uveitis responded well to antitumor necrosis factor (TNF)-alpha (adalimumab) for 5 months subsequently. Severe uveitis recurred soon after discontinuation of anti-TNF alpha therapy and could not be controlled well with reinstitution of the anti-TNF alpha therapy. Read More

BMC Ophthalmol 2018 Oct 5;18(1):261. Epub 2018 Oct 5.

Division of Rheumatology, Marmara University School of Medicine Fevzi Çakmak Mah, Muhsin Yazıcıoğlu Cad. No:10 Pendik, Istanbul, Turkey.

Background: To report the switch rate of conventional immunosuppressive (CIS) therapies to the biological agents (BA) in patients with refractory Behcet's uveitis (BU).

Methods: In this retrospective study, clinical records were reviewed of 76 patients' 116 eyes presenting with BU who had been treated with immunosuppressive drug therapy. Mann Whitney U test was used for the intergroup comparisons of parameters without normal distribution as well as calculation of descriptive statistical methods (mean, standard deviation, median, frequency and rate). Read More

Pediatr Rev 2018 Oct;39(10):519-522

Department of Pediatrics, CMC Myers Park Pediatrics/CHS-Levine Children's, Charlotte, NC.

Atherosclerosis 2018 Oct;277:341-346

Ege Univ Faculty of Med, Izmir, Turkey.

Background And Aims: Familial hypercholesterolemia (FH) is a common genetic disease of high-level cholesterol leading to premature atherosclerosis. One of the key aspects to overcome FH burden is the generation of large-scale reliable data in terms of registries. This manuscript underlines the important results of nation-wide Turkish FH registries (A-HIT1 and A-HIT2). Read More

Int J Pediatr Otorhinolaryngol 2018 Nov 20;114:26-28. Epub 2018 Aug 20.

Izmir Dr. Behcet Uz Training and Research Hospital, Department of Pediatric Intensive Care Unit, Turkey.

Pediatric sudden sensorineural hearing loss (SSNHL) is a quite rare otologic emergency. Etiology of SSNHL isn't enough clear. Electronic cigarette (EC) is a device that uses increasingly and it contain liquid which keep nicotin and various chemicals. Read More

Ophthalmologica 2018 Sep 21:1-5. Epub 2018 Sep 21.

Department of Ophthalmology, Uludag University School of Medicine, Bursa, Turkey.

Purpose: Investigation of the efficacy of intravitreal dexamethasone implants (0.7 mg) in patients with Behçet disease (BD) who had cystoid macular edema (CME) despite immunomodulatory treatment.

Materials And Methods: Twenty-seven eyes of 20 patients who had intravitreal dexameth-asone implant injections and follow-up for more than 6 months were included in this study. Read More

Acta Ophthalmol 2018 Sep 21. Epub 2018 Sep 21.

Rega Institute for Medical Research, Department of Microbiology and Immunology, University of Leuven, KU Leuven, Leuven, Belgium.

Purpose: To determine the concentrations of the CC chemokines CCL2, CCL7, CCL8, CCL11, CCL13, CCL20, CCL24 and CCL26 in aqueous humour (AH) samples from patients with specific uveitic entities.

Methods: Aqueous humour samples from patients with active uveitis associated with Behçet's disease (BD) (n = 13), sarcoidosis (n = 8), HLA-B27-related inflammation (n = 12), Vogt-Koyanagi-Harada (VKH) disease (n = 12) and control patients (n = 9) were assayed with the use of a multiplex assay.

Results: When considering all uveitis patients as one group, all chemokine levels except CCL2 were significantly increased compared to controls. Read More

Semin Thorac Cardiovasc Surg 2018 18;30(3):379-380. Epub 2018 Sep 18.

Department of Surgery, University of Alabama Birmingham School of Medicine, Birmingham, Alabama.. Electronic address:

Viruses 2018 09 19;10(9). Epub 2018 Sep 19.

Department of Biomedical Science, Ajou University School of Medicine, Suwon 16499, Korea.

Behçet's disease (BD) affects multiple organs. It is mainly characterized by recurrent oral, skin, and genital aphthous ulcers, and eye involvement. Successful management of BD is increasing, although its etiology remains unclear. Read More

Clin Rheumatol 2018 Sep 18. Epub 2018 Sep 18.

Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey.

Behçet's disease (BD) is a chronic inflammatory disease. The etiopathogenesis of BD is not well understood and several cytokines and genetic factors have been investigated. Interleukin (IL)-37, which a member of IL-1 family is an anti-inflammatory cytokine. Read More

Noro Psikiyatr Ars 2018 Sep 4;55(3):256-260. Epub 2018 Jun 4.

Celal Bayar University Hospital, Psychiatry Department, Manisa, Turkey.

Introduction: This study aimed to assess the validity and reliability of Turkish version of DSM-5 Level 2 Sleep Disorders Scale.

Method: The scale was prepared by translation and back translation of DSM-5 Level 2 Sleep Disorders Scale. Study groups consisted of a clinical sample that contained cases that had sleep related problems and treated in a child and adolescent psychiatry unit and also a community sample. Read More

J Med Vasc 2018 Sep 25;43(5):332-334. Epub 2018 Aug 25.

Service de chirurgie vasculaire, CHU Ibn-Sina, Rabat, Maroc.

Behçet's disease is a vasculitis of unknown etiology. Vascular involvement is rare, but may be inaugural in many cases. We report a case of Behçet's disease revealed by a symptomatic pseudo-aneurysm of the external iliac artery. Read More

J Autoimmun 2018 Sep 11. Epub 2018 Sep 11.

Department of Experimental and Clinical Medicine, University of Firenze, Italy. Electronic address:

Objective: To evaluate the efficacy and safety of secukinumab in Behçet's patients with active mucocutaneous and articular manifestations refractory to previous treatments.

Methods: We retrospectively evaluated 5 patients treated with the IL17-inhibitor secukinumab and diagnosed with Behçet according to ISG/ICBD criteria. All patients had active mucocutaneous and articular manifestations refractory to colchicine, conventional DMARDs and at least one anti-TNFα agent. Read More