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    Intrinsic changes of left ventricular function in patients with Behçet disease and comparison according to systemic disease activity.
    Echocardiography 2018 Feb 16. Epub 2018 Feb 16.
    Division of Cardiology, Department of Internal Medicine, School of Medicine, Chungnam National University, Chungnam National University Hospital, Daejeon, Korea.
    Purpose: Although cardiac manifestation of Behçet disease (BD) has been described in sporadic reports, its timely diagnosis remains difficult. The objective of this study was to describe early cardiac manifestations of BD. We also performed a comprehensive classification of systemic BD activity and compared their cardiac manifestations. Read More

    Ulcerative colitis followed by the development of typical intestinal Behçet disease: A case report.
    Medicine (Baltimore) 2018 Feb;97(7):e9882
    Department of Gastroenterology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
    Rationale: Intestinal Behçet disease (intestinal BD) and inflammatory bowel disease (IBD) share a lot of characteristics, including genetic background, clinical manifestations, and therapeutic strategies, especially the extraintestinal manifestations, such as oral ulcers, arthralgia, eye lesions, skin lesions, etc, but the coexistence of these 2 diseases are uncommon. Behçet disease with gastrointestinal involvement in ulcerative colitis (UC) patient has been reported in just 1 previous case report, but, which can not be diagnosed as definite intestinal BD based on Korean novel diagnositic criteria due to lacking the typical ileocecal ulcer.

    Patient Concerns: We present a 23-year-old woman with ulcerative disease who developed typical intestinal BD, which is the first case report of patient with coexisting UC and typical intestinal BD. Read More

    Evaluation of the effects of miRNAs in familial Mediterranean fever.
    Clin Rheumatol 2018 Feb 13. Epub 2018 Feb 13.
    Faculty of Medicine, Department of Medical Genetic, Ege University, Izmir, Turkey.
    Familial Mediterranean fever (FMF) is an inherited autoinflammatory disorder that can result in attacks with accompanying recurrent episodes of fever, serositis, and skin rash. MiRNAs are demonstrated to be associated with a number of other diseases; however, no comprehensive study has revealed its association with FMF disease. The aim is to investigate the role of microRNAs in FMF. Read More

    Hughes-Stovin Syndrome as an Outcome of Behçet Disease or as a Different Entity.
    Korean J Thorac Cardiovasc Surg 2018 Feb 5;51(1):64-68. Epub 2018 Feb 5.
    Department of Cardiovascular Surgery, Kirikkale University Faculty of Medicine.
    Hughes-Stovin syndrome is a rare disorder of unknown etiology. Although the association between multiple pulmonary artery aneurysms and venous thrombosis of the lower limbs was reported by Beattie and Hall in 1911, it was not until 1962 that the eponym "Hughes-Stovin syndrome" was formally introduced in the medical literature. We describe 2 patients with Hughes-Stovin syndrome who presented with pulmonary artery aneurysm, thrombophlebitis, hemoptysis, and oral ulcers, review the manifestations of the disease, and compare its similarities with and differences from Behçet disease. Read More

    A nation-wide survey of patients with homozygous familial hypercholesterolemia phenotype undergoing LDL-apheresis in Turkey (A-HIT 1 registry).
    Atherosclerosis 2018 Jan 29;270:42-48. Epub 2018 Jan 29.
    Ankara University Medical Faculty Ibn-i Sina Hospital, Department of Hematology, Ankara, Turkey.
    Background And Aims: Homozygous familial hypercholesterolemia (HoFH) is a genetic condition characterized by lethally high levels of low-density lipoprotein cholesterol (LDL-C) from birth, and requires rapid and aggressive intervention to prevent death due to coronary heart disease and/or atherosclerosis. Where available, lipoprotein apheresis (LA) is the mainstay of treatment to promote survival.

    Methods: A-HIT1 registry was conducted with the aim of providing insight to the real-life management of HoFH patients undergoing LA in Turkey, where LA procedures are fully reimbursed and widely available. Read More

    Surgical strategy for refractory aortitis.
    Gen Thorac Cardiovasc Surg 2018 Feb 5. Epub 2018 Feb 5.
    Department of Cardiovascular Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
    In some instances, we encounter cases suffered from inflammatory aortic diseases (aortitis) in Japan, some of which are at the active stages with systemic inflammation. Most of them are refractory with some technical difficulties of surgical treatment. The aortic wall, particularly, at the active stage, is too fragile to hold the surgical sutures. Read More

    Frequencies of IL-15Rα+ cells in patients with Behçet's disease and the effects of overexpressing IL-15Rα+ on disease symptoms in mice.
    Cytokine 2018 Jan 27. Epub 2018 Jan 27.
    Department of Biomedical Science, Ajou University School of Medicine, Suwon 16499, Republic of Korea; Department of Microbiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea. Electronic address:
    It has been suggested higher serum levels of IL-15 and lower expression levels of IL-15 receptor alpha (IL-15Rα) are correlated with pathogenesis of Behçet's disease (BD). However, whether overexpressing IL-15Rα could be used as a therapeutic candidate for BD is currently unclear. Therefore, the purpose of this study was to determine whether overexpressing IL-15Rα could affect BD symptoms in a mouse model. Read More

    Post-transplant malignancies in pediatric liver transplant recipients: Experience of two centers in Turkey.
    Turk J Gastroenterol 2018 Jan;29(1):87-91
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University School of Medicine, İzmir, Turkey.
    Background/aims: A liver transplant is the preferred treatment for patients with end-stage liver disease, as it usually results in longterm survival. However, due to the use of chronic immunosuppressive therapy, which is necessary to prevent rejection, de novo cancer is a major risk after transplantation. The aim of this study was to assess the incidence of post-transplant malignancies in children after liver transplantations. Read More

    Infliximab associated with life-threatening lung infection in a patient with Behcet disease with intestinal and hematopoietic system involvement: A case report.
    Medicine (Baltimore) 2017 Dec;96(50):e9202
    Rheumatology and Immunology Department.
    Rationale: Tumor necrosis factor (TNF-α) participates in the pathophysiology of Behcet's disease (BD) and myelodysplastic syndrome (MDS). Infliximab is recommaned for the most severe type of BD, however, there is little evidence for its effectiveness in BD associated MDS.

    Patient Concerns: A 46-year-old female, initially diagnosed with intestinal BD and leukopenia was later diagnosed as MDS. Read More

    Characteristic Echocardiographic Manifestations of Behçet's Disease.
    Ultrasound Med Biol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
    The objective of this study was to determine the characteristic echocardiographic manifestations of Behçet's disease. Ninety-seven Behçet's patients admitted to our hospital from January 2002 to December 2016 were retrospectively analyzed. There were 63 patients (64. Read More

    Symptom management in Behcets disease.
    J Pak Med Assoc 2018 Jan;68(1):46-49
    Department of Internal Medicine Nursing, Ege University Medical Faculty Hospital, Rheumatology Polyclinic, Turkey.
    Objective: To determine the symptoms experienced by patients diagnosed with Behcet's Disease and how they cope with them.

    Methods: The qualitative study was conducted from September 2013 to March 2014 at Ege University Medical Faculty Hospital, Turkey, comprising patients having all symptoms of Behcet's Disease. Data was collected through semi-structured focus-group interview form. Read More

    Association of circulating resistin, leptin, adiponectin and visfatin levels with Behçet disease: a meta-analysis.
    Clin Exp Dermatol 2018 Jan 22. Epub 2018 Jan 22.
    Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea.
    Background: Behçet disease (BD) is a chronic inflammatory disease. Adipokines are synthesized in adipose tissue, and have been reported to play important roles in the pathogenesis of autoimmune and inflammatory diseases, including BD.

    Aim: To evaluate the relationship between circulating blood adipokine levels and BD. Read More

    Solitary median maxillary central incisor, holoprosencephaly and congenital nasal pyriform aperture stenosis in a premature infant: case report.
    Arch Argent Pediatr 2018 Feb;116(1):e130-e134
    Tepecik Training and Research Hospital, Department of Neonatology, Izmir,Turkey.
    Solitary median maxillary central incisor syndrome is a rare disorder involving midline abnormalities such as holoprosencephaly, nasal cavity anomalies, cleft palate-lip, hypotelorism, microcephaly, and panhypopituitarism. Congenital nasal pyriform aperture stenosis is a lethal cause of neonatal respiratory distress due to narrowing of the pyriform aperture anteriorly and it can be confused with choanal atresia. In this report, we present a newborn infant with solitary median maxillary central incisor syndrome accompanied by other abnormalities including holoprosencephaly, nasal pyriform aperture stenosis, microcephaly and panhypopituitarism. Read More

    Markers of inflammation and tolerance development in allergic proctocolitis.
    Arch Argent Pediatr 2018 Feb;116(1):e1-e7
    Dr. Behcet Uz Children Training and Research Hospital, Pediatric Allergy and Immunology Department, Izmir, Turkey.
    Background: Today, as a result of an increase in the frequency of food protein-induced allergic proctocolitis (FPIAP), there is a need for studies not only to enlighten the pathophysiology of the disease but also to determine simple, non-invasive markers in both diagnosis, and evaluation of the development of tolerance. No study has been found in the literature about the place of neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV), which are easy to calculate and non-invasive markers.

    Objectives: The purpose is to determine the relation between NLR and MPV with the diagnosis and development of tolerance in children with FPIAP. Read More

    Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies.
    Ann Neurol 2018 Jan 12. Epub 2018 Jan 12.
    Department of Neuroscience, Drug and Child Health, University of Florence, Florence, Italy.
    Objectives: In multiple sclerosis (MS), magnetic resonance imaging (MRI) is a sensitive tool for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous cases are frequent in clinical practice. Detection of perivenular lesions in the brain (the "central vein sign") improves the pathological specificity of MS diagnosis, but comprehensive evaluation of this MRI biomarker in MS-mimicking inflammatory and/or autoimmune diseases, such as central nervous system (CNS) inflammatory vasculopathies, is lacking. In a multicenter study, we assessed the frequency of perivenular lesions in MS versus systemic autoimmune diseases with CNS involvement and primary angiitis of the CNS (PACNS). Read More

    Rapid loss of efficacy of biosimilar infliximab in three patients with Behçet's disease after switching from infliximab originator.
    Eur J Rheumatol 2017 Dec 25;4(4):288-290. Epub 2017 Oct 25.
    Division of Rheumatology, Azienda USL Toscana Centro, Hospital of Prato, Italy.
    Three patients affected by Behçet's disease (BD) with severe uveitis and neurological involvement in stable clinical remission and who rapidly relapsed after switching from reference infliximab (re-IFX) to biosimilar infliximab (bio-IFX) are reported. In order to observe the rules of local health authorities, two males and one female (38, 26, and 40 years old, respectively) with BD complicated by severe uveitis and neuro-Behçet and who were in prolonged remission, were switched from re-IFX to bio-IFX, with the same dosing regimen of 5 mg/kg intravenous infusions every 8 weeks. All three patients experienced disease flare-ups, with recurrence of uveoretinitis in the first patient, neuro-Behçet in the second, and uveitis and neuro-Behçet in the third after 1, 3, and 2 infusions, respectively. Read More

    Behçet syndrome: a contemporary view.
    Nat Rev Rheumatol 2018 Feb 3;14(2):107-119. Epub 2018 Jan 3.
    New York University School of Medicine, NYU Hospital for Joint Diseases, Department of Medicine (Rheumatology), 333 East 38th Street, New York, NY, 10016, USA.
    The presence of symptom clusters, regional differences in disease expression and similarities with, for example, Crohn's disease suggest multiple pathological pathways are involved in Behçet syndrome. These features also make formulating disease criteria difficult. Genetic studies have identified HLA-B*51 to be the important genetic risk factor. Read More

    Molecular analysis of interleukin-10 gene polymorphisms in patients with Behçet's disease.
    Immunol Lett 2018 Feb 30;194:56-61. Epub 2017 Dec 30.
    Connective Tissue Research Center, Tabriz University of Medical Science, Iran; Department of Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
    Background: Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that play a fundamental role in restrictive host immune response to pathogens, by means of that is a crucial importance for chronic inflammatory disease studies. Therefore, the goal of this study was to measure the correlation of the IL-10 gene polymorphisms with the susceptibility to Behçet's disease compared with the control group in the Azeri population and to determine the expression of this gene in the two groups. Also, real-time PCR was performed for evaluate the IL-10 mRNA expression of the associated polymorphisms. Read More

    Cancer risk in Korean patients with Behçet's disease: A nationwide population-based study.
    PLoS One 2017 29;12(12):e0190182. Epub 2017 Dec 29.
    Department of Biostatistics, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea.
    Background: Various immune-mediated diseases are associated with increased malignancy risks. However, the relationship between Behçet's disease (BD) and cancer remains unclear. We conducted a nationwide, population-based study to determine the risk of cancer in patients with BD. Read More

    Associations between,andand Behçet's disease but not VKH syndrome in Han Chinese.
    Oncotarget 2017 Dec 23;8(62):105037-105046. Epub 2017 Oct 23.
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China.
    The present study was designed to explore the interrelationship between single nucleotide polymorphisms (SNP) of the tumor necrosis factor superfamily (TNFSF) and its respective receptor superfamily (TNFRSF) genes and Behcet's disease (BD) and Vogt-Koyanagi-Harada syndrome (VKH) in Han Chinese. The study sample included 796 patients with BD, 792 patients with VKH syndrome, and 1604 healthy controls. The genotyping of 35 SNPs was performed by MassARRAY platform (Sequenom), iPLEX Gold Assay, PCR-restriction fragment length polymorphism assay and TaqMan SNP assay. Read More

    [A case of chronic progressive neuro-Behçet disease with extensive cerebral atrophy and elevated CSF IL-6 activity treated with infliximab].
    Rinsho Shinkeigaku 2018 Jan 22;58(1):30-34. Epub 2017 Dec 22.
    Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences.
    A 43-year-old man without a previous episode of uveitis presented with slowly progressive neurological symptoms that appeared within the past year such as dysarthria, ataxic gait, and behavioral changes. Brain MRI findings showed atrophic lesions in the brainstem and cerebellum. Because these clinical symptoms and abnormal MRI findings indicated spinocerebellar degeneration as the initial diagnosis, he was admitted to our hospital. Read More

    Brain biopsy to aid diagnosis of neuro-Behçet's disease: Case report and literature review.
    eNeurologicalSci 2017 Sep 3;8:2-4. Epub 2017 Jun 3.
    Department of Neurology, Nitobe Memorial Nakano General Hospital, Japan.
    Central nervous system involvement in Behçet's disease (Neuro-Behçet's disease: NBD) has been reported to present diverse clinical and pathological manifestations. A few cases presenting with neurological symptoms preceding other systemic features are difficult to be diagnosed. Here we suggest the clinical benefit of brain biopsy with a case of NBD initially presenting neurological symptoms. Read More

    Multiple aneurysms and gastrointestinal involvement in Behcet's disease: A case report.
    Medicine (Baltimore) 2017 Dec;96(49):e9131
    aDepartment of Nephrology and Rheumatology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinabSingapore Thong Chai Medical Institution, Singapore.
    Rationale: Behcet's disease (BD) is a rare systemic vasculitis disorder that can involve vessels of any size.

    Patient Concerns: A 60-year-old female had recurrent painful mouth ulcers about 30 years ago and recently presented with abdominal distension, conjunctival congestion, and chest pain in sequence.

    Diagnoses: The patient was diagnosed with BD according to the International Criteria for Behcet's Disease (ICBD). Read More

    Ten-year progress of coronary artery lesions prior to Behçet disease diagnosis: A case report and care-compliant article.
    Medicine (Baltimore) 2017 Dec;96(49):e9102
    State Key Laboratory of Cardiovascular Disease, Emergency and Critical Care Center, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
    Introduction: Behçet disease is a multisystemic chronic inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. However, particularly part of patients would present cardiovascular involvements and vascular lesions could be the presenting sign of Behçet disease preceding classical symptoms. We presented a middle aged male patient, in whom abdominal aorta pseudoaneurysm was as the first leading sign to reveal Behçet disease, and with his coronary artery lesions progress through a 10-year period before Behçet disease was diagnosed. Read More

    Miscellaneous skin disease and the metabolic syndrome.
    Clin Dermatol 2018 Jan - Feb;36(1):94-100. Epub 2017 Sep 8.
    Department of Dermatology, Istanbul Medeniyet University, Medical School, Istanbul, Turkey. Electronic address:
    The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has only recently attracted interest. Some inflammatory skin diseases, such as vitiligo, scleredema, recurrent aphthous stomatitis, Behçet disease, rosacea, necrobiosis lipoidica, granuloma annulare, skin tags, knuckle pads, and eruptive xanthomas, have possible associations with MetS. Read More

    A Case of Aortic Regurgitation Presenting with Recurrent Detachment of a Prosthetic Valve, as the First Presenting Symptom of Cardiovascular Behçet's Disease.
    Intern Med 2017 Dec 8. Epub 2017 Dec 8.
    Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan.
    A 33-year-old man with severe aortic regurgitation underwent initial aortic valve replacement (AVR). During the 2 years after AVR, 3 reoperations for prosthetic valve detachment were required. During hospitalization, he had no typical clinical findings, with the exception of a persistent inflammatory reaction; a pseudo-aneurysm around the Bentall graft developed 27 days after the 4th operation. Read More

    The prevalence of Behçet's disease in the north of Jordan: a hospital-based epidemiological survey.
    Clin Exp Rheumatol 2017 Nov-Dec;35 Suppl 108(6):51-54. Epub 2017 Nov 27.
    Cerrahpaşa Hospital, University of Istanbul, Turkey.
    Objectives: To estimate the prevalence of Behçet's disease (BD) in Jordan, with the additional aim of comparing this prevalence among hospital workers in other geographical areas.

    Methods: In the first stage of our survey, 2,569 employees from 6 hospitals in north Jordan were interviewed using a screening questionnaire to identify individuals with recurrent oral ulcers (ROU), a previous diagnosis of BD (PDBD) and/or any major symptom related to BD. In the second stage, all individuals with ROU or PDBD identified at stage 1, were examined by 2 rheumatologists for the presence/confirmation of BD according to the International Study Group (ISG) criteria. Read More

    Updated treatment strategies for intestinal Behçet's disease.
    Korean J Intern Med 2018 Jan 8;33(1):1-19. Epub 2017 Dec 8.
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
    Behçet's disease (BD) is a chronic, idiopathic, relapsing immune-mediated disease involving multiple organs, and is characterized by recurrent oral and genital ulcers, ocular disease, gastrointestinal ulcers, vascular diseases, and skin lesions. In particular, gastrointestinal involvement in BD is followed by severe complications, including massive bleeding, bowel perforation, and fistula, which can lead to significant morbidity and mortality. However, the management of intestinal BD has not yet been properly established. Read More

    Mean Platelet Volume: A Reliable Marker of Inflammation in Recurrent Apthous Stomatitis and Behçet Disease?
    Indian Dermatol Online J 2017 Nov-Dec;8(6):468-470
    Department of Biostatistics, Faculty of Medicine, Hitit University, Çorum, Turkey.
    Background: Mean platelet volume (MPV) is an indicator of platelet activation and aggregation. MPV has been found to be related with the inflammation of certain disorders in recent studies.

    Aims: We sought to investigate whether MPV could be an indicator of inflammation in patients with Behçet disease (BD) and recurrent apthous stomatitis (RAS). Read More

    [Management of isolated iliac aneurysms: A Tunisian center experience].
    J Med Vasc 2017 Dec 1;42(6):349-357. Epub 2017 Nov 1.
    Service de chirurgie cardiovasculaire et thoracique, hôpital Habib-Bourguiba, avenue Mmajida-Boulila, 3029 Sfax, Tunisie.
    Isolated aneurysms of the iliac arteries are rare. The diagnoses of these aneurysms become easier with non-invasive radiologic investigations. The development of endovascular treatment is a recent alternative to surgical treatment. Read More

    Hughes-Stovin syndrome revealing the presence of Behçet's Disease.
    Caspian J Intern Med 2017 ;8(4):332-334
    Department of Internal Medicine and Endocrinology, Fattouma Bourguiba Hospital, University of Monastir, Tunisia.
    Background: Hughes-Stovin Syndrome (HSS) is a rare clinical disorder characterized by deep venous thrombosis and multiple pulmonary and/or bronchial aneurysms. Aneurysms in systemic circulation can also be seen.

    Case Presentation: We report the first case of HSS with aortic aneurysm in a 55-year-old man who initially presented with deep venous thrombosis. Read More

    Imaging manifestations of Behcet's disease: Key considerations and major features.
    Eur J Radiol 2018 Jan 21;98:214-225. Epub 2017 Nov 21.
    Department of Radiology, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
    Behcet's disease is an autoimmune disease most commonly seen in the Middle East. Although primarily known with painful oral and genital ulcers, it can lead to vasculitis. Therefore, several associated complications such as thrombotic syndromes, aneurysmal arterial disease may arise. Read More

    Aberrant expression of interleukin-10 and activation-induced cytidine deaminase in B cells from patients with Behçet's disease.
    Biomed Rep 2017 Dec 4;7(6):520-526. Epub 2017 Oct 4.
    Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea.
    Despite extensive studies, the pathogenesis of Behçet's disease (BD) remains unclear. In particular, the roles of B cells in patients with BD have not been elucidated. Activation-induced cytidine deaminase (AID) is a critical enzyme for immunoglobulin (Ig) heavy chain class switching and somatic hypermutation in B cells and the abnormal expression of AID in various immune conditions has previously been studied. Read More

    Multiple Sclerosis with Onset Younger Than 10 Years in Turkey.
    Neuropediatrics 2018 02 28;49(1):51-58. Epub 2017 Nov 28.
    Department of Pediatric Neurology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
    Objective: To identify the demographics, clinical characteristics, disease course, treatment patterns, and disability levels of multiple sclerosis (MS) patients with onset under the age of 10 years (early onset multiple sclerosis, EOMS).

    Methods: EOMS patients were reviewed retrospectively in detailed records from 27 child neurology centers. Patients with preschool (≤7 years) and school age (>7 years) onset were compared. Read More

    Scientific people named in the classification of vasculitis.
    Rev Bras Reumatol Engl Ed 2017 Nov - Dec;57(6):605-609. Epub 2016 Aug 25.
    Adnan Menderes University Medical Faculty, Department of Rheumatology, Aydin, Turkey.
    The first International Chapel Hill Consensus Conference was held in 1994. There have been suggestions about the nomenclature of systemic vasculitis. Important categories were added to the classification of vasculitis, and many changes were made for disease names in the second Chapel Hill Consensus Conference 2012, which were not included in the Chapel Hill Consensus Conference 1994. Read More

    Surgical Removal of a Ruptured Radiculomedullary Artery Aneurysm: A Case Report.
    J Cerebrovasc Endovasc Neurosurg 2017 Sep 30;19(3):217-222. Epub 2017 Sep 30.
    Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, Korea.
    Subarachnoid hemorrhage due to a solitary spinal aneurysm is extremely rare, and diagnosis and treatment are challenging. We report a rare case of a ruptured radiculomedullary artery aneurysm in a patient with Behçet disease. A 49-year-old man presented with severe lower abdominal and leg pain. Read More

    Gastrointestinal Involvement in Behçet Disease.
    Rheum Dis Clin North Am 2018 Feb;44(1):45-64
    Division of Gastroenterology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Koca Mustafa Pasa Mahallesi, Cerrahpaşa Caddesi No:53, 34096 Fatih/Istanbul, Turkey. Electronic address:
    Behçet disease (BD) is a variable vessel vasculitis that can involve several organs and systems. Gastrointestinal (GI) involvement has an acute exacerbating course with ulcers, most commonly in the ileocolonic area. These ulcers can be large and deep, causing perforation and massive bleeding. Read More

    Macrophages from Behcet's Disease Patients Express Decreased Level of Aryl Hydrocarbon Receptor (AHR) mRNA.
    Iran J Allergy Asthma Immunol 2017 Oct;16(5):418-424
    Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, connecting environmental stimulators with the immune system. M1 macrophages are a part of immune system that contribute to the inflammatory events in the pathogenesis of Behcet's disease (BD). The effect of AHR on the macrophages in BD patients is still unclear. Read More

    Non-invasive vascular biomarkers in patients with Behçet's disease: review of the data and future perspectives.
    Clin Exp Rheumatol 2017 Nov-Dec;35 Suppl 108(6):100-107. Epub 2017 Oct 6.
    Department of Pathophysiology; and Joint Academic Rheumatology Program, Medical School of the National & Kapodistrian University of Athens, Greece.
    Vascular inflammation in small to large veins and arteries contributes substantially to mortality above that of the general population in Behçet's disease. Recent data verified also the presence of accelerated classical subclinical arterial damage (atheromatosis, arteriosclerosis, arterial hypertrophy) even in patients free of overt vascular complications, and may be complementary to that of vasculitis. Early detection of such vascular damage might provide helpful pathophysiological insight and potentially even guide treatment management. Read More

    Pure red aplasia induced by sodium valproate in a patient with Behçet's syndrome.
    Clin Exp Rheumatol 2017 Nov-Dec;35 Suppl 108(6):132. Epub 2017 Oct 27.
    Rheumatology Institute of Lucania (IRel) and Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera; and the Basilicata Ricerca Biomedica (BRB) Foundation, Italy.

    Infliximab for uveitis of Behçet's syndrome: a trend for earlier initiation.
    Clin Exp Rheumatol 2017 Nov-Dec;35 Suppl 108(6):86-89. Epub 2017 Oct 24.
    Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
    Objectives: The prognosis of uveitis in Behçet's syndrome (BS) has improved over decades. Whether this is related to the use of more aggressive management strategies is not known.

    Methods: This is a retrospective study of BS patients who received infliximab (IFX) for refractory eye disease between 2003-2015. Read More

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