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World J Clin Cases 2021 Apr;9(12):2854-2861

Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China.

Background: Behcet's disease (BD) is a chronic disease characterized by oral and vulvar ulcers as well as eye and skin damage and involves multiple systems. It presents as an alternating process of repeated attacks and remissions. Esophageal venous rupture and bleeding caused by BD is rarely reported at home and abroad. Read More

J Dermatol 2021 May 7. Epub 2021 May 7.

Department of Dermatology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Metabolic syndrome (MetS) is characterized by insulin resistance, high blood pressure/sugar, dyslipidemia, and obesity. Whether MetS and its components affect the development of Behçet's disease (BD) remains unclear. This study was performed to investigate the associations between metabolic syndrome and risk of BD using nationwide population data. Read More

Front Neurol 2021 15;12:595984. Epub 2021 Apr 15.

Department of Neurology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

Neuro Behçet's disease (NBD) is a rare but most aggressive manifestation of Behçet's disease (BD) with a poor prognosis, and some patients even present a relapsing and treatment-resistant progressive course. In some relapsing NBD cases, traditional corticosteroids and immunosuppressive drugs show limited efficacy, while benefits of biological agents, such as anti-B-lymphocyte CD20 biological agent rituximab (RTX), gradually represent potential therapeutic advantages with clinical rapid remission and long-time maintenance. However, up to now, the optimal dosage of RTX in NBD is still elucidated. Read More

Turk J Pediatr 2021 ;63(2):273-281

Divisions of Hematology, Department of Pediatrics, University of Health Sciences, Dr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, İzmir, Turkey.

Background: Nephrotic syndrome (NS) is a common kidney disease associated with an increased risk of thrombotic events. The aim of this study was to assess the prothrombotic potential of patients with NS using the thrombin generation assay (TGA).

Methods: A total of 35 patients with NS, who were followed in the Division of Pediatric Nephrology in Behcet Uz Children`s Hospital, were included in the study. Read More

Ann Dermatol 2021 Feb 30;33(1):73-76. Epub 2020 Dec 30.

Department of Dermatology, Gyeongsang National University School of Medicine, Jinju, Korea.

Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an uncommon skin eruption and characterized histopathologically by the presence of granulomatous inflammation with or without leukocytoclastic vasculitis. PNGD is known to be associated with various immune-mediated connective tissue diseases such as rheumatoid arthritis and lupus erythematosus. However, to our knowledge, a case of PNGD in a patient with Behçet's disease is extremely rare and only one case has been reported in foreign literature to date. Read More

Immunol Lett 2021 Apr 23. Epub 2021 Apr 23.

Department of Immunology, Aziz Sancar Institute of Experimental Medicine (Aziz Sancar DETAE), Istanbul University, Istanbul, Turkey. Electronic address:

Innate lymphoid cells (ILCs) are lymphoid cells that have important effector and regulatory functions in innate immunity and tissue remodeling. Uncontrolled activation and proliferation of ILCs can contribute to inflammatory autoimmune diseases. Behcet's disease (BD) is a complex systemic inflammatory disorder of unknown etiology. Read More

Integr Med Res 2021 Sep 17;10(3):100720. Epub 2021 Feb 17.

Department of Physiology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Behçet's disease (BD) is a chronic inflammatory systemic disease that affects multiple organs. The causes of BD are still unknown, but it is primarily characterized by autoimmune reaction in the blood vessels. Current research focuses on treatments that can reduce the non-typical inflammatory responses of BD. Read More

Reumatismo 2021 Apr 19;73(1):32-43. Epub 2021 Apr 19.

Department of Internal Medicine, Geriatric Unit, Hospital Fattouma Bourguiba of Monastir, Monastir, Tunisia; Biochemistry Laboratory, LR12ES05 LR-NAFS Nutrition - Functional Food and Vascular Health, Faculty of Medicine, University of Monastir, Monastir.

The aim was to investigate the frequency and spectrum of cardiac involvement (CI) in patients with Behçet syndrome (BS) in the Tunisian context, and to assess the clinical and imaging features, treatment, and outcomes. We retrospectively retrieved the medical records of patients with CI among 220 BS patients admitted to the hospital internal medicine department between February 2006 and April 2019, who fulfilled the International Study Group diagnostic criteria for BS. Ten patients (8 men, 2 women) were eligible for the study. Read More

Ann Clin Microbiol Antimicrob 2021 Apr 17;20(1):25. Epub 2021 Apr 17.

Department of Pediatric Infectious Disease, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Background: Methicillin-resistant Staphylococcus aureus (MRSA) strains are prevalent in healthcare services. Medical students are at risk for MRSA carriage, subsequent infection and potential transmission of nosocomial infection.Few studies have examined MRSA carriage among medical students. Read More

Eur J Clin Invest 2021 Apr 13:e13572. Epub 2021 Apr 13.

Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, Italy - IRCCS Rheumatology Unit, San Martino Polyclinic, University of Genoa, Genoa, Italy.

Background: Uveitis is one of the most frequent ophthalmologic manifestations in rheumatology. Uveal inflammation can underlie a systemic inflammatory rheumatic disease (SIRD) in approximately 30% of cases with a significant burden on the quality of life since it represents a cause of blindness in up to 20% of cases in Western countries.

Methods: In this review, we provide a comprehensive overview of the pathophysiology of uveitis associated with SIRDs. Read More

Lab Med 2021 Apr 14. Epub 2021 Apr 14.

Hacettepe University Faculty of Medicine, Pediatric Hematology Unit, Ankara, Turkey.

Objective: To investigate the value of presepsin and proadrenomedullin (proADM) as new markers for febrile neutropenia, by comparing them with conventional markers.

Methods: Plasma specimens for presepsin, proADM, C-reactive protein (CRP), and procalcitonin (PCT) were collected every 3 days during each episode of febrile neutropenia.

Results: A total of 39 patients experiencing a collective 47 episodes of febrile neutropenia with hematological malignant neoplasms, as well as 40 healthy control patients without infectious disease, were enrolled in this study. Read More

Reumatol Clin 2021 Apr 10. Epub 2021 Apr 10.

Universidade Positivo, Curitiba, PR, Brazil.

Am J Ophthalmol 2021 Apr 9. Epub 2021 Apr 9.

Members of the SUN Working Group are listed online at ajo.com.

Purpose: To determine classification criteria for Behçet disease uveitis.

Design: Machine learning of cases with Behçet disease and 5 other panuveitides.

Methods: Cases of panuveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Read More

Autoimmunity 2021 May 9;54(3):176-180. Epub 2021 Apr 9.

Department of Dermatology and Veneorology, Ufuk University, Ankara, Turkey.

Objective: Pathogenesis of Behçet disease (BD) has not yet been clearly revealed and there is no ideal test for the estimation of disease activation at present. This study aimed to assess the efficiencies of IgG/IgM and IgA/C3 ratios in determining activation of BD.

Method: This retrospective cohort study consisted of 140 patients with BD. Read More

Pharmacol Res 2021 May 4;167:105593. Epub 2021 Apr 4.

Rheumatology Unit, Department of Experimental and Internal Medicine, University of Messina, Messina, Italy. Electronic address:

Behçet disease (BD) is a complex, multi-systemic inflammatory condition mainly hallmarked by oral and genital ulcers which can also affect the vessels, gastrointestinal tract, central nervous system and even the axial skeleton. Without a clear classification among autoimmune or autoinflammatory conditions, BD has been recently classified as a MHC-I-opathy. BD aetiology is still obscure, but it is thought that certain microorganisms can elicit an aberrant adaptive immune response in the presence of a permissive genetic background. Read More

Indian J Sex Transm Dis AIDS 2020 Jul-Dec;41(2):198-201. Epub 2020 Jul 31.

Department of SKIN and VD, S.B.K.S. Medical Institute and Research Center, Dhiraj Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.

Behcet's disease (BD) is a chronic, relapsing, inflammatory vascular disease with no diagnostic or pathognomonic test. Here, we present a case of 26-year-old male with a complaint of recurrent oral, genital, and cutaneous lesions. The diagnosis of BD was confirmed on the basis of revised the International Criteria for BD. Read More

Gen Hosp Psychiatry 2021 Mar 5;70:103-108. Epub 2021 Mar 5.

Department of Rheumatology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Dudley Road, Birmingham B18 7QH, United Kingdom.

Objectives: To measure health utilities Time Trade-Off (TTO) and Standard Gamble (SG) in Behcet's disease (BD), and explore the interrelationships with EQ-5D-5L, disease activity, depression, anxiety and fatigue.

Methods: TTO, SG, EQ-5D-5L, EQ VAS, depression (PHQ-9), anxiety (GAD-7) and fatigue (MAF) questionnaires were administered to 103 adult BD patients. Disease activity was assessed using the Behçet's Disease Activity Index (BDAI). Read More

Medicine (Baltimore) 2021 Apr;100(13):e24990

Department of Rheumatology and Immunology, West China hospital, Sichuan University, Chengdu, Sichuan Province, PR China.

Rationale: Orogenital ulcers can be observed in various conditions, such as Behcet disease, infection and also paraneoplastic pemphigus (PNP). Castleman disease (CD), which is a rare cause of paraneoplastic pemphigus represents a heterogenous lymphoproliferative disorder of unknown etiology. Paraneoplastic pemphigus associated with CD in pregnancy is rare and has not been reported yet. Read More

Gynecol Endocrinol 2021 May 31;37(5):476-479. Epub 2021 Mar 31.

Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey.

Introduction: Persistent müllerian duct syndrome (PMDS) is a rare form of 46, XY disorder of sex development characterized by the persistence of the müllerian structures (uterus, fallopian tubes, the upper part of the vagina) in phenotypically and genotypically normal males. This disease occurs as a result of impairment in the synthesis, release or effect of anti-Müllerian hormone (AMH) during the embryonic period. Approximately 85-88% of PMDS cases have been reported to have or mutation. Read More

Clin Case Rep 2021 Mar 18;9(3):1453-1456. Epub 2021 Jan 18.

ENT Department University of Sfax, Faculty of Medicine of Sfax Sfax Tunisia.

Retropharyngeal edema, uncommon in superior vena cava syndrome, can exceptionally represent the first manifestation of Behcet's disease, which should be taken into account in the differential diagnosis of this condition. Read More

J Chest Surg 2021 Feb;54(1):79

Department of Radiology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

BMC Surg 2021 Mar 25;21(1):164. Epub 2021 Mar 25.

Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Sichuan, 610000, Chengdu, People's Republic of China.

Background: Prosthetic valve detachment is not rare after aortic valve replacement in Behcet's disease. However, destruction of the intervalvular fibrous body (IFB) due to Behcet's disease was rarely reported.

Case Presentation: We report a case of 30 year-old woman, with valve detachment and IFB separation. Read More

Arch Med Sci 2021 26;17(2):569-573. Epub 2021 Feb 26.

Department of Neurology, The Second Hospital of Hebei Medical University, Rizhao Central Hospital, Shijiazhuang, China.

J Fr Ophtalmol 2021 Mar 16. Epub 2021 Mar 16.

Département d'ophtalmologie, Centre Hospitalier Universitaire de Nancy, Vandœuvre-lès-Nancy, France.

Purpose: To evaluate if the presence of uveitis in Behçet's disease (BD) is associated with a particular clinical phenotype and to analyze the prognostic impact of a missed diagnosis of BD at the time the uveitis is diagnosed.

Materiel And Methods: Ophthalmologic and systemic clinical features of 51 patients with BD were recorded retrospectively. We compared the clinical phenotype of patients with ocular manifestations with those without ocular manifestations. Read More

Rheumatology (Oxford) 2021 Mar 18. Epub 2021 Mar 18.

Département de Biothérapies (CIC-BTi) et Inflammation-Immunopathologie-Biothérapie (I2B), AP-HP, Hôpital La Pitié-Salpêtrière, Paris, F-75651, France.

Objectives: Behçet disease (BD) is a chronic systemic inflammatory disorder of unknown aetiology. The aim of this study was to determine the orientation of T cell subpopulations in pediatric BD and more precisely to look for a regulatory T lymphocytes (Tregs)/Th17 imbalance.

Methods: T cell subpopulations were analyzed by flow cytometry in the peripheral blood of pediatric patients with acute (aBD, n = 24), remitting (rBD, n = 12) BD, and in healthy controls (HC, n = 24). Read More

J Inflamm Res 2021 8;14:737-744. Epub 2021 Mar 8.

Rheumatology and Rehabilitation Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background And Aim: The data about the role of regulatory B cells (Breg) in Behcet Disease (BD) are scarce. We aimed to evaluate the frequency of total B lymphocytes and Breg cells in different BD phenotypes and therapies attempting to unravel their function.

Methods: This cross-sectional study included 35 BD patients and 39 healthy controls (HCs). Read More

Front Genet 2021 26;12:638236. Epub 2021 Feb 26.

Laboratory of Transmission, Control and Immunobiology of Infections, Institut Pasteur de Tunis, Tunis, Tunisia.

Inflammatory demyelinating disorders of the central nervous system are debilitating conditions of the young adult, here we focus on multiple sclerosis (MS) and neuro-Behçet disease (NBD). MS is an autoimmune disorder of the central nervous system. NBD, a neurological manifestation of an idiopathic chronic relapsing multisystem inflammatory disease, the behçet disease. Read More

Front Neurol 2021 23;12:642088. Epub 2021 Feb 23.

Department of Neurology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Behçet disease (BD) is an autoimmune and vasculitic disorder. BD affects the veins more frequently than the arteries. The cerebral venous sinus thrombosis (CVST) was reported to occur in about 20% of neuro-BD. Read More

Case Rep Neurol 2021 Jan-Apr;13(1):78-83. Epub 2021 Feb 8.

Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

We report 2 cases of probable neuro-Behçet's disease (NBD) with longitudinally extensive transverse myelitis (LETM). In both cases, the patients presented paraplegia, as well as sensory, bladder, and rectal disturbances. Magnetic resonance imaging (MRI) of patient 1 showed continuous high signal intensity extending from the midbrain to the entire spinal cord in the central part of the cord on T2-weighted imaging (T2WI). Read More

Metab Brain Dis 2021 Mar 11. Epub 2021 Mar 11.

Department of Pediatrics, Division of Pediatric Metabolism and Nutrition, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.

Cerebrotendinous xanthomatosis (CTX) is a lipid storage disease caused by deficiency of sterol 27-hydroxylase enzyme encoded by CYP27A1 gene. This multicenter, cross-sectional descriptive study aimed to document clinical characteristics of CTX patients of different ages, clinical presentations of early-diagnosed patients, and responses to short-term chenodeoxycholic acid (CDCA) treatment. Seven of 11 CTX patients were diagnosed in childhood. Read More