Clin Dermatol 2017 Sep - Oct;35(5):477-483. Epub 2017 Jun 27.

Department of Dermatology, University of California, Davis School of Medicine, Sacramento, CA. Electronic address:

Although the surfaces of both the skin and oral mucosa are protected by squamous epithelial cells and fall within the scope of dermatologic practice, the oral cavity contains highly specialized structures and functions distinct from other skin biology and pathologic conditions and are also the purview of clinicians who care for patients with skin and mucosal diseases. We describe the distinct features of the tongue, mucosa, and salivary glands. In particular, we examine the composition and function of the saliva, with special focus on salivary biomarkers. Read More

Clin Dermatol 2017 Sep - Oct;35(5):421-434. Epub 2017 Jun 27.

Gazi University Faculty of Medicine, Department of Dermatology Emeritus Prof, Ankara, Turkey; Dermatology and Laser Center, Reduitstrasse 13, Landau, Germany. Electronic address:

Behçet disease is currently considered an "autoinflammatory disease" triggered by infection and environmental factors in genetically predisposed individuals. Although the disease is characterized by recurrent oral and genital aphthous ulcers and ocular involvement, it can affect multiple organ systems. Complex aphthosis is characterized by recurrent oral and/or genital aphthous ulcers. Read More

J Curr Ophthalmol 2017 Sep 26;29(3):210-213. Epub 2017 Jun 26.

Doheny Eye Institute, Los Angeles, CA, USA.

Purpose: To evaluate choroidal thickness in patients with non-ocular Behçet's disease (BD) using spectral domain optical coherence tomography (SD-OCT) and to compare the results to normal eyes.

Methods: In this retrospective observational comparative study, we collected OCT and clinical data from the charts of 4 patients (7 eyes) with BD who had been referred for a screening eye exam and had a normal ocular examination. Data from 9 healthy volunteers (17 eyes) were collected as age-matched controls. Read More

Ocul Immunol Inflamm 2017 Sep 14:1-6. Epub 2017 Sep 14.

a Department of Ophthalmology , American University of Beirut , Beirut , Lebanon.

Purpose: Investigate the efficacy of intravitreal adalimumab in breakthrough panuveitis in patients on systemic adalimumab for more than 3 months.

Methods: Retrospective study of patients on systemic adalimumab with breakthrough panuveitis requiring intravitreal adalimumab therapy.

Results: Seven eyes of four patients with Adamantiades-Behçet disease panuveitis were included and all were maintained on systemic adalimumab for 7. Read More

Intern Med J 2017 Sep;47(9):1086-1088

Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.

Oncotarget 2017 Aug 19;8(31):51277-51287. Epub 2017 Apr 19.

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China.

Aberrant methylation of interferon regulatory factor 8 (IRF8) has been noted in various tumors. IRF8 has also been reported to be involved in many autoimmune diseases, including Behcet's disease (BD). However, the methylation status of IRF8 in BD has not been reported. Read More

Maedica (Buchar) 2017 Jan;12(1):55-58

Professor of Neurogenetics, Department of Medical Genetics, Motahrai Hospital, Urmia University of Medical Sciences, Iran.

We report a case of partial deletion of 9p with partial trisomy of 1q42 syndrome, which is a rare clinical and cytogenetic report. The dysmorphic features of the patient include microcephaly, plagiocephaly, trigonocephaly with metopic ridge, arched eyebrows, hypertelorism, down-slanting palpebral fissure, ptosis, blepharophimosis, unilateral left epicanthic fold, long eyelashes, low-set and posteriorly rotated ears, long philtrum, anteverted nares, retrognathia and unilateral undescended testis. Chromosomal analysis revealed partial monosomy of 9p24 associated with partial trisomy of 1q42q>ter. Read More

J Craniofac Surg 2017 Aug 31. Epub 2017 Aug 31.

*Department of Otorhinolaryngology, Bezmiâlem Vakif University, Medical Faculty, Fatih †Department of Otorhinolaryngology, Acibadem University, Maslak Hospital ‡Department of Otorhinolaryngology, Gaziosmanpasa Taksim Research and Education Hospital §Department of Neurology, Istanbul Medipol University, Istanbul, Turkey.

Introduction: Neurologic involvement associated with Behçet disease (BD) is defined as a different entity: Neuro-Behçet disease (NBD). Behçet disease presents with olfactory dysfunction. It is not known whether this is the consequence of mucosal involvement or neurologic involvement. Read More

J Multidiscip Healthc 2017 14;10:309-319. Epub 2017 Aug 14.

Division of Rheumatology, Department of Internal Medicine.

Behçet's syndrome (BS) is a multisystem vasculitis that presents with a variety of mucocutaneous manifestations such as oral and genital ulcers, papulopustular lesions and erythema nodosum as well as ocular, vascular, gastrointestinal and nervous system involvement. Although it occurs worldwide, it is especially prevalent in the Far East and around the Mediterranean Sea. Male gender and younger age at disease onset are associated with a more severe disease course. Read More

Sci Rep 2017 Aug 31;7(1):10196. Epub 2017 Aug 31.

Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Neuro-Behçet's disease (NBD) is subcategorized into parenchymal-NBD (P-NBD) and non-parenchymal-NBD types. Recently, P-NBD has been further subdivided into acute P-NBD (A-P-NBD) and chronic progressive P-NBD (CP-P-NBD). Although an increasing number of studies have reported the various clinical features of A-P-NBD and CP-P-NBD over the last two decades, there was a considerable inconsistency. Read More

J Autoimmun 2017 Aug 24. Epub 2017 Aug 24.

Institute of Neurological Sciences and Psychiatry, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Department of Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address:

Autoimmune and dysimmune inflammatory mechanisms on a genetically susceptible background are implicated in the etiology of Behçet's Disease (BD). Heat-shock protein-65 (HSP-65) derived from Streptococcus sanguinis was proposed as a triggering factor based on its homology with human HSP-60. However, none of the autoantigens identified so far in sera from BD share common epitopes with bacterial HSP-65 or has a high prevalence. Read More

Clin Neurol Neurosurg 2017 Oct 12;161:48-50. Epub 2017 Aug 12.

Internal Medicine Department, French Reference Centre for Rare Autoimmune Systemic Diseases, e3 m Institute, Assistance-Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France; Paris VI University (UPMC), Sorbonnes Universités, Paris, France.

Sci Rep 2017 Aug 16;7(1):8453. Epub 2017 Aug 16.

Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), Sevilla, 41013, Spain.

Behçet's disease (BD) is an immune-mediated systemic disorder with a well-established association with HLA class I and other genes. BD has clinical overlap with many autoinflammatory diseases (AIDs). The aim of this study was to investigate the role of rare variants in seven genes involved in AIDs: CECR1, MEFV, MVK, NLRP3, NOD2, PSTPIP1 and TNFRSF1A using a next generation sequencing (NGS) approach in 355 BD patients. Read More

Immunol Lett 2017 Aug 12;190:177-184. Epub 2017 Aug 12.

Unit Research 12SP15 "Expression moléculaire des interactions cellulaires et leur mode de communication dans le poumon profond", A. Mami Hospital, Ariana, Tunisia; Université de Tunis El Manar, Faculty of Medicine of Tunis, Department of Basic Sciences, Tunis, Tunisia; Division of Pulmonology, Department of Paediatric Respiratory Diseases, Abderrahman Mami Hospital, Pavillon B, Ariana, Tunisia.

Behçet's disease (BD) is a multi-systemic inflammatory disorder characterized by the "triple symptom complex". Several pro-inflammatory cytokines, mainly derived from the immune Th17 axis, seem to be involved in different pathogenic pathways leading to development of the clinical manifestations. Here, we have analyzed the expression and role of IL-26 in active BD patients, an inflammatory disorder characterized by bronchoalveolar lavage fluid (BAL) and cerebrospinal fluid (CSF) inflammation. Read More

Int J Rheum Dis 2017 Aug 14. Epub 2017 Aug 14.

Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Objectives: Behçet's disease (BD) has been recognized as an unclassified type of vasculitis with an accompanying tendency to thrombosis. No disease-specific pathology has been demonstrated so far to explain the prothrombotic state, and this predisposition is considered to be associated with endothelial activation/dysfunction. P-selectin glycoprotein ligand-1 (PSGL-1) variable number of tandem repeat (VNTR) polymorphism has an impact on the protein length, and heterozygosity affect of the PSGL-1 to P-selectin interaction, which has been found to be associated with an increased risk of thrombosis in patients with antiphospholipid syndrome. Read More

Intern Med 2017 Sep 10;56(17):2377-2378. Epub 2017 Aug 10.

Department of Neurology, Nitobe Memorial Nakano General Hospital, Japan.

Atlas Oral Maxillofac Surg Clin North Am 2017 Sep;25(2):113-126

Department of Comprehensive Dentistry, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

Korean Circ J 2017 Jul 27;47(4):477-482. Epub 2017 Jul 27.

Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA.

Background And Objectives: Behçet's disease (BD) is a systemic vasculitis that is characterized by genital, oral, or skin lesions, uveitis, and vascular complications. Studies have shown that increased arterial stiffness is common in systemic immune and inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus. However, current research has not yet determined whether patients with BD have increased arterial stiffness. Read More

Medicine (Baltimore) 2017 Jul;96(30):e7353

aDepartment of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University bKey Laboratory of Myopia, Ministry of Health cShanghai Key Laboratory of Visual Impairment and Restoration of Shanghai, Fudan University, Shanghai, China.

To evaluate the visual outcomes of cataract surgery in patients with uveitis, and to determine risk factors for the recurrence of uveitis and postoperative complications.Eighty patients with uveitis who underwent phacoemulsification with intraocular lens (IOL) implantation were included in this retrospective study. We analyzed the following data: patient characteristics, medications used, visual acuity, and complications of cataract surgery. Read More

Arch Argent Pediatr 2017 Aug;115(4):e245-e248

Department of Pediatric Allergy, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.

Hydrocarbon aspiration (HA) can cause significant lung disease by inducing an inflammatory response, hemorrhagic exudative alveolitis, and loss of surfactant function. The most serious side effect of HA is aspiration pneumonia. Pneumothorax, pneumatocele, acute respiratory distress syndrome (ARDS), pulmonary abscess, bronchopleural fistula, bilateral hemorrhagic pleural effusion and pyopneumothorax were previously reported. Read More

J Oral Pathol Med 2017 Jul 17. Epub 2017 Jul 17.

Department of Oral and Maxillofacial Surgery, University Hospital of Heraklion, Heraklion, Greece.

The collected works of Hippocrates describe for the first time in a systematic way a large number of oral diseases, such as ulcers, inflammations, abscesses and tumours from the epiglottis, mouth, tongue, palate, uvula and the sublingual area. Several of these case reports are remarkable for the accurate observation of clinical symptoms and signs, the aetiology, the pathogenesis and their therapeutic approach in relation to prognosis. The Hippocratic authors report cases of aphthae as part of a polysystemic disease, described many centuries later by Behçet and Adamantiades, while they associate features of splenomegaly from endemic malaria with gingivitis (ulitis). Read More

Eur J Radiol 2017 Jun 28. Epub 2017 Jun 28.

Dr. Behçet Uz Children's Education and Research Hospital, Department Pediatric Radiology 35210, Konak, Izmir, Turkey. Electronic address:

Objective: To emphasize the diverse diagnostic imaging findings of pediatric Behçet's disease and to define the fundamental imaging clues for pulmonary, vascular, gastrointestinal and central nervous system involvements of Behçet's disease in pediatric age group. We also aim to list the major imaging differences of Behçet's disease in childhood and adulthood.

Conclusion: The diagnosis of pediatric Behçet's disease is challenging. Read More

Eur J Pharmacol 2017 Oct 12;813:42-49. Epub 2017 Jul 12.

Department of Microbiology, Ajou University School of Medicine, Suwon 443-380, Republic of Korea; Department of Biomedical Science, Ajou University School of Medicine, Suwon 443-380, Republic of Korea. Electronic address:

CD206 is a macrophage mannose receptor involved in variety of autoimmune and inflammatory diseases. This study aimed to identify the pathogenic role of CD206 in a herpes simplex virus (HSV) induced Behçet's disease (BD) mouse model. CD206 positive cells were detected in peripheral blood mononuclear cells and quantified by flow cytometry. Read More

J Med Vasc 2017 May 27;42(3):185-188. Epub 2017 Apr 27.

Service de chirurgie vasculaire, CHU Ibn Sina, 165, rue Abdelkrim Khattabi, numéro 3, Souissi, Rabat, Maroc.

Vascular involvement in Behçet's disease often present as venous thrombosis. Arterial damage is rare. We report a case of Behçet's disease occurring in a 40-year-old woman revealed by a false aneurysm of the left common carotid artery. Read More

J Med Vasc 2017 Jul 27;42(4):234-236. Epub 2017 Jun 27.

Service de médecine interne, centre hospitalier Pierre-le-Damany, 22300 Lannion, France.

Behçet's disease is a systemic inflammatory disorder with a wide variety of cardiovascular complications. Intracranial aneurysm is extremely rare. Herein, we are presenting a 41-year-old male with Behçet's disease and a headache. Read More

J Med Vasc 2017 Jul 2;42(4):213-220. Epub 2017 Jun 2.

Service de chirurgie cardiovasculaire et thoracique, hôpital Habib Bourguiba, 3029 Sfax, Tunisie.

Non-infectious aortitis is usually due to giant-cell arteritis, Takayasu disease or Behçet disease. The main aortic lesions are stenoses, occlusions and aneurysms in the Takayasu disease and aneurysms in the Behçet disease and giant-cell arteritis. Treatment is based on corticosteroid therapy and surgery. Read More

Ocul Immunol Inflamm 2017 Jul 12:1-8. Epub 2017 Jul 12.

b Marmara University School of Medicine , Chief, Division of Rheumatology , Istanbul , Turkey.

Purpose: To assess the long-term efficacy and safety of pegylated interferon alpha-2b (peg-IFN-α-2b) for severe uveitis associated with Behçet's disease.

Methods: Peg-IFN-α-2b was administrated at an initial dosage of 0,5-1,5 µg/kg/week. If any complications were observed, the dosage was tapered. Read More

Surg Neurol Int 2017 5;8:97. Epub 2017 Jun 5.

Neurosurgery Department, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.

Background: Behçet's disease (BD) is an inflammatory multisystem disease with unknown etiology, and consists of a TRIAD comprising recurrent oral ulcers, genital ulcers, and uveitis. In some cases, the disease affects the central nervous system, called Neuro-Behçet Disease (NBD). Few cases of NBD simulating a brain tumor have been previously reported. Read More

EXCLI J 2017 4;16:609-617. Epub 2017 May 4.

Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biology, Tokat, Turkey.

Behçet's disease (BD) is an autoimmune multisystemic disease. The precise etiology of BD is not fully understood; however, it is thought that interactions between genetic and environmental factors play an essential role in its pathogenesis. The nuclear receptor coactivator-5 (NCOA5) gene encodes a coregulator for nuclear receptor subfamily 1 group D member 2 (NR1D2) and estrogen receptor 1 and 2 (ESR1 and ESR2). Read More

Eur J Paediatr Neurol 2017 Jun 29. Epub 2017 Jun 29.

Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey.

Objective: To document the clinical and paraclinical features of pediatric multiple sclerosis (MS) in Turkey.

Methods: Data of MS patients with onset before age 18 years (n = 193) were collected from 27 pediatric neurology centers throughout Turkey. Earlier-onset (<12 years) and later-onset (≥12 years) groups were compared. Read More

Pan Afr Med J 2017 25;26:237. Epub 2017 Apr 25.

Service d'Ophtalmologie, Hôpital Militaire d'Instruction Mohamed V de Rabat, Maroc.

Our study aimed to determine the clinical, therapeutic and prognostic features of ocular involvement in patients with Behçet's disease treated in our Department of ophthalmology. We conducted a retrospective data collection from medical records of 20 patients treated at the military hospital in Laayoune. All patients underwent complete ophthalmological examination and fluorescein angiography if necessary. Read More

Med Clin (Barc) 2017 Sep 5;149(6):261-266. Epub 2017 Jul 5.

Institut Clínic d'Oftalmologia, Hospital Clínic de Barcelona, Barcelona, España.

The term retinal vasculitis (RV) encompasses a heterogeneous group of sight-threatening conditions that are included in the intraocular inflammatory diseases that affect the posterior segment of the eye. Based on the nature of the inflammatory process, RV are classified into predominantly inflammatory or ischaemic (occlusive RV). The diagnosis is clinical and the aetiology can be infectious or non-infectious (immune-mediated). Read More

J Clin Neurosci 2017 Oct 3;44:230-233. Epub 2017 Jul 3.

Bujanov Moscow City Clinical Hospital, Multiple Sclerosis Center № 1, Moscow, Russia.

Multiple sclerosis is a chronic demyelinating disorder of the central nervous system. There are many cases of multiple sclerosis - like syndrome and demyelinating disorders in systemic lupus erythematosus, Sjogren disease, Behcet disease and other autoimmune conditions. Coexistence of ankylosing spondylitis and multiple sclerosis usually is rare but in this article we report 4 Russian patients with concomitant multiple sclerosis and ankylosing spondylitis diseases. Read More

Intest Res 2017 Jul 12;15(3):422-428. Epub 2017 Jun 12.

Department of Pediatrics, Gachon University Gil Hospital, Incheon, Korea.

We report the case of a 5-year-old male patient with multiple aseptic splenic abscesses associated with Behçet's disease. The patient visited Gachon University Gil Hospital with fever, abdominal pain, and acute watery and bloody diarrhea, and reported a 2-year history of chronic abdominal pain and intermittent watery diarrhea. He was treated with antibiotics at a local clinic for fever and cervical lymph node swelling. Read More

Intest Res 2017 Jul 12;15(3):395-401. Epub 2017 Jun 12.

Center for Advanced IBD Research and Treatment, Kitasato Institute Hospital, Kitasato University, Tokyo, Japan.

Background/aims: Intestinal Behçet's disease (BD) is an immune-mediated inflammatory disorder. We followed up the patients and evaluated safety profile and effectiveness of adalimumab for the treatment of intestinal BD through 100 weeks rolled over from the 52 week clinical trial (NCT01243671).

Methods: Patients initiated adalimumab therapy at 160 mg at week 0, followed by 80 mg at week 2, followed by 40 mg every other week until the end of the study. Read More

Intest Res 2017 Jul 12;15(3):318-327. Epub 2017 Jun 12.

The Third Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.

Behçet's disease (BD) is a chronic relapsing disease involving multiple organ systems. BD is characterized clinically by oral and genital aphthae, cutaneous lesions, and ophthalmological, neurological, and/or gastrointestinal manifestations. It is widely recognized that the presence of intestinal lesions may be a poor prognostic factor in intestinal BD, increasing the risk of surgery and decreasing the quality of life. Read More

Intest Res 2017 Jul 12;15(3):311-317. Epub 2017 Jun 12.

Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.

Intestinal Behçet's disease (BD), generally accepted as a type of inflammatory bowel disease (IBD), could be diagnosed when patients with BD have objectively documented gastrointestinal symptoms and intestinal ulcerations. Similar to IBD, intestinal BD has an unpredictable disease course with relapse and remission and is often related to a poor prognosis. However, there is no single gold standard for assessment of the disease activity of intestinal BD, and its diagnosis and management depend heavily on expert opinions. Read More

J Gastroenterol Hepatol 2017 Jun 30. Epub 2017 Jun 30.

Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.

Background/Aims Many patients with intestinal Behçet's disease (BD) still suffer from gastrointestinal symptoms despite the disease being in endoscopic or radiological remission. Previous studies report that small intestinal bacterial overgrowth (SIBO) can be associated with inflammatory bowel disease. However, there have been no reports about SIBO in patients with intestinal BD. Read More

J Child Adolesc Psychopharmacol 2017 Jun 30. Epub 2017 Jun 30.

2 Department of Child and Adolescent Psychiatry, Dokuz Eylül University Faculty of Medicine , Izmir, Turkey .

Medwave 2017 Jun 20;17(5):e6978. Epub 2017 Jun 20.

Servicio de Neurología, Departamento de Medicina, Hospital Daniel Alcides Carrión, Callao, Perú; Unidad de Post Grado, Facultad de Medicina San Fernando, Universidad Nacional Mayor de San Marcos, Lima, Perú.

Behçet's disease is a vasculitis that can cause inflammatory lesions in multiple organs or systems including the nervous system. Most cases worldwide have been reported along what is called the "Silk Route" from the Mediterranean region to Japan, so it is considered a rare disease in Latin American countries. The frequency of neurological involvement ranges from 5 to 13%. Read More

J Cancer Res Ther 2017 Apr-Jun;13(2):284-290

Department of Pediatric Oncology, Dokuz Eylul University Institute of Oncology, Izmir, Turkey.

Background: The national protocol aimed to improve the outcome of the high risk neuroblastoma patients by high-dose chemotherapy and stem cell rescue with intensive multimodal therapy.

Materials And Methods: After the 6 induction chemotherapy cycles, patients without disease progression were nonrandomly (by physicians' and/or parent's choices) allocated into two treatment arms, which were designed to continue the conventional chemotherapy (CCT), or myeloablative therapy with autologous stem cell rescue (ASCR).

Results: Fifty-six percent (272 patients) of patients was evaluated as high risk. Read More

Diagn Interv Imaging 2017 Jun 19. Epub 2017 Jun 19.

Department of Radiology, Cerrahpasa faculty of medicine, Istanbul university, KMPasa, 34098 Istanbul, Turkey. Electronic address:

Metabolism 2017 Jul 27;72:109-119. Epub 2017 Apr 27.

Division of Endocrinology and Metabolism, Brehm Center for Diabetes Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Objective: Familial partial lipodystrophy (FPLD) is a rare genetic disorder characterized by partial lack of subcutaneous fat.

Methods: This multicenter prospective observational study included data from 56 subjects with FPLD (18 independent Turkish families). Thirty healthy controls were enrolled for comparison. Read More

Allergol Immunopathol (Madr) 2017 Jun 17. Epub 2017 Jun 17.

Marmara University Faculty of Medicine, Department of Pediatric Pulmonology, Istanbul, Turkey.

Background: The presence of atopy is considered as a risk factor for severe respiratory symptoms in children. The objective of this study was to examine the effect of atopy on the course of disease in children hospitalised with viral pneumonia.

Methods: Children between the ages of 1 and 6 years hospitalised due to viral pneumonia between the years of 2013 and 2016 were included to this multicentre study. Read More

Ter Arkh 2017;89(5):79-82

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.

Behçet's disease (BD) is systemic vasculitis of unknown etiology, which is more common in the countries located along the Great Silk Road. The disease is diagnosed if a patient has 4 key diagnostic signs: aphthous stomatitis, genital sores, and eye and skin lesions. Vascular diseases referred to as minor criteria for BD are characterized by the formation of aneurysms and thrombosis, predominantly in the venous bed. Read More

Case Rep Radiol 2017 24;2017:8061648. Epub 2017 May 24.

Section of Radiological Sciences, Department of Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Policlinico "G. Martino", Via Consolare Valeria 1, 98100 Messina, Italy.

Behçet's disease (BD) is a multisystem disorder of unknown aetiology, characterized by recurrent oral ulcers, genital ulcers, uveitis, skin lesions, and pathergy. Gastrointestinal disease outside the oral cavity is well recognized and usually takes the form of small intestinal ulcers, with the most significant lesions frequently occurring in the ileocaecal region. Symptoms usually include nausea, vomiting, colicky abdominal pain, and change in bowel habit and it is not unusual that patients may present late, with life-threatening complications requiring surgery. Read More

Arch Oral Biol 2017 Oct 12;82:115-120. Epub 2017 Jun 12.

Division of Periodontology, Malatya Oral and Dental Health Hospital, The Turkish Ministry of Health, Malatya, Turkey.

Objective: Recently, increasing concern has been focused on the contribution of oxidative stress in the pathology of periodontal disease and diabetes mellitus. Firstly, the present study aimed to analyze gingival crevicular fluid (GCF), salivary, and serum oxidative status in children with type 1 diabetes mellitus (T1DM) at diagnosis and systemically healthy children with and without gingivitis. Additionally, the diabetic patients were reevaluated after diabetes and periodontal treatment. Read More

Int J Rheum Dis 2017 Jun 19. Epub 2017 Jun 19.

Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Aim: Behcet's disease (BD) is a chronic, inflammatory disease with multisystem involvement. Adherence to treatment is low in chronic diseases as well as inflammatory and autoimmune diseases. This study assessed factors associated with non-adherence to treatment in patients with BD. Read More

Tuberk Toraks 2017 Mar;65(1):56-59

Clinic of Pediatric Immunology and Allergy, Dr. Behçet Uz Children Diseases Training and Research Hospital, Izmir, Turkey.

Chronic granulomatous disease (CGD) is a genetically heterogeneous primary immunodeficiency that is characterized by recurrent and life-threatening infections resulting from defects in phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system and granuloma formation due to increased inflammatory response. The most commonly involved organs are the lungs, skin, lymph nodes, and liver due to infection. It may present with recurrent pneumonia, hilar lymphadenopathy, empyema, abscess, reticulonodular patterns, and granulomas due to lung involvement. Read More

Turk J Med Sci 2017 Jun 12;47(3):942-946. Epub 2017 Jun 12.

Department of Pediatric Neurology, Dr. Behçet Uz Children's Training and Research Hospital, İzmir, Turkey.

Background/aim: Diabetes mellitus (DM) is one of the most common metabolic diseases seen in the world today. Diabetic neuropathy (DN) is a chronic complication of the disease that is rarely reported in children, since it has a relatively longer latency period. Our main objective in this study is to determine the incidence rate of DN in pediatric DM patients and assess the risk factors associated with DN. Read More