12,398 results match your criteria Behavioural brain research[Journal]


NLRP3 inflammasome-dependent pyroptosis and apoptosis in hippocampus neurons mediates depressive-like behavior in diabetic mice.

Behav Brain Res 2020 May 23:112684. Epub 2020 May 23.

School of Kinesiology, The Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai 200438, PR China. Electronic address:

A relatively large number of diabetic patients risk complications of clinical depression that lead to poorer quality of life, however the precise mechanisms for diabetes-associated depression are not fully understood. Links between hyperglycemia-induced oxidative stress and NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation have been reported in the pathogenesis of diabetes. The present study aimed to elucidate the contribution of NLRP3-mediated apoptotic/pyroptotic neuronal cell death to diabetes-associated depression. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112684DOI Listing

Coregulation of sleep-pain physiological interplay by orexin system: An unprecedented review.

Behav Brain Res 2020 May 23:112650. Epub 2020 May 23.

Student Research Committee, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.

Accumulating evidence support the critical role of endogenous orexin system in modulation of various physiological functions. Among these, regulation of pain and wakefulness have extensively been investigated, however, by independent series of studies each focusing a distinct side. It is now well established that orexins induce potent analgesic effect via affecting their receptors within several specific brain structures. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112650DOI Listing

Auditory event-related potentials in individuals with subjective and mild cognitive impairment.

Behav Brain Res 2020 May 21:112700. Epub 2020 May 21.

Institute of Movement and Neurosciences, German Sport University, Cologne, Germany; VasoActive Research Group, School of Health and Sport Sciences, University of the Sunshine Coast, Qld, Australia.

Objective: The analysis of event-related potentials (ERPs) is a useful tool to differentiate between healthy older adults, and individuals with mild cognitive impairment (MCI). Less is known about the ERPs' sensitivity of differentiating between individuals with subjective cognitive impairment (SCI) and MCI, as early evidence indicates similar brain alterations between these two groups. In order, to establish tests that are sensitive to subclinical impairment, this study compared auditory evoked ERPs between individuals with SCI and MCI. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112700DOI Listing

Cathodal tDCS stimulation of left anterior temporal lobe eliminates cross-category color discrimination response time advantage.

Behav Brain Res 2020 May 20:112682. Epub 2020 May 20.

Koç University, Department of Psychology, Istanbul, Turkey; Koç University, Research Center for Translational Medicine, Istanbul, Turkey. Electronic address:

The linguistic category-advantage in color perception refers to better discrimination performance for stimuli that belong to different categories (e.g., green vs. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112682DOI Listing

Drug instrumentalization.

Behav Brain Res 2020 May 19:112672. Epub 2020 May 19.

Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany. Electronic address:

Psychoactive drugs with addiction potential are widely used by people of virtually all cultures in a non-addictive way. In order to understand this behaviour, its population penetrance, and its persistence, drug instrumentalization was suggested as a driving force for this consumption. Drug instrumentalization theory holds that psychoactive drugs are consumed in a very systematic way in order to make other, non-drug-related behaviours more efficient. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112672DOI Listing

Microglia dependent BDNF and proBDNF can impair spatial memory performance during persistent inflammatory pain.

Behav Brain Res 2020 May 19:112683. Epub 2020 May 19.

Physiology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Inflammatory pain is commonly associated with cognitive impairment. However, its molecular mechanisms are poorly understood. Thus, this study was conducted to investigate the molecular mechanisms of behavioral changes associated with inflammatory pain. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112683DOI Listing

Musicians use speech-specific areas when processing tones: The key to their superior linguistic competence?

Behav Brain Res 2020 May 19:112662. Epub 2020 May 19.

Department of Neurology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, 79106, Freiburg, Germany. Electronic address:

It is known that musicians compared to non-musicians have some superior speech and language competence, yet the mechanisms how musical training leads to this advantage are not well specified. This event-related fMRI study confirmed that musicians outperformed non-musicians in processing not only of musical tones but also syllables and identified a network differentiating musicians from non-musicians during processing of linguistic sounds. Within this network, the activation of bilateral superior temporal gyrus was shared with all subjects during processing of the acoustically well-matched musical and linguistic sounds, and with the activation distinguishing tones with a complex harmonic spectrum (bowed tone) from a simpler one (plucked tone). Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112662DOI Listing

Enriching hippocampal memory function in older adults through video games.

Behav Brain Res 2020 May 18:112667. Epub 2020 May 18.

Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, United States. Electronic address:

Healthy aging is accompanied by a steady cognitive decline with clear losses in memory. Animal studies have consistently demonstrated that simply modifying an animal's living environment (known as environmental enrichment) can have a positive influence on age-related cognitive decline in the hippocampus. Previously, we showed that playing immersive 3D video games can improve hippocampal-based memory in young healthy adults, suggesting that the exploration of the large open worlds of modern-day video games may act as proxy for environmental enrichment in humans. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112667DOI Listing

The auditory context-dependent attenuation of taste neophobia depends on D1 dopamine receptor activity in mice.

Behav Brain Res 2020 May 10:112687. Epub 2020 May 10.

Department of Psychobiology, Institute of Neurosciences, Center for Biomedical Research (CIBM), University of Granada, Spain.

Taste recognition memory in rodents is evident as taste neophobia disappears upon repeated taste exposures without aversive consequences, thus increasing the consumption of familiar edibles. The attenuation of taste neophobia (AN) induced by taste familiarity is auditory context-dependent in mice since neophobia to a familiar taste reappears with a novel auditory background. This effect depends on the integrity of the dorsal hippocampus but the potential role of dopamine has remained unexplored. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112687DOI Listing

Angiotensin (1-7) through modulation of the NMDAR-nNOS-NO pathway and serotonergic metabolism exerts an anxiolytic-like effect in rats.

Behav Brain Res 2020 May 11;390:112671. Epub 2020 May 11.

Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, PR China. Electronic address:

Although recent studies have shown that angiotensin (1-7) (Ang [1-7]) exerts anti-stress and anxiolytic-like effects, the underlying mechanisms remain elusive. The ventral hippocampus (VH) is proposed to be a critical brain region for mood and stress management through the N-methyl-d-aspartate receptor (NMDAR) signaling pathway. However, the role of VH NMDAR signaling in the effects of Ang (1-7) remains unclear. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112671DOI Listing

Allopregnanolone induces antidepressant-like effects through BDNF-TrkB signaling independent from AMPA receptor activation in a rat learned helplessness model of depression.

Behav Brain Res 2020 May 11;390:112670. Epub 2020 May 11.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

Allopregnanolone (ALLO, 3α5α-tetrahydroprogesterone) was found to be effective for depressed patients. Animal models of depression indicate that ALLO is associated with the pathophysiology of depression. Traditional antidepressant drugs produce antidepressant effects via the monoamine system, with consequent up-regulation of brain-derived neurotrophic factor (BDNF). Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112670DOI Listing

Extended access self-administration of methamphetamine is associated with age- and sex-dependent differences in drug taking behavior and recognition memory in rats.

Behav Brain Res 2020 May 8;390:112659. Epub 2020 May 8.

Department of Psychology, University of Illinois at Urbana-Champaign, USA; Neuroscience Program, University of Illinois at Urbana-Champaign, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, USA. Electronic address:

Individuals who begin drug use during early adolescence experience more adverse consequences compared to those initiating later, especially if they are female. The mechanisms for these age and gender differences remain obscure, but studies in rodents suggest that psychostimulants may disrupt the normal ontogeny of dopamine and glutamate systems in the prefrontal cortex (PFC). Here, we studied Sprague-Dawley rats of both sexes who began methamphetamine (METH, i. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112659DOI Listing

The concept of akrasia as the foundation for a dual systems theory of addiction.

Authors:
Nick Heather

Behav Brain Res 2020 May 11;390:112666. Epub 2020 May 11.

Department of Psychology, Northumbria University, 8 Roseworth Terrace, NE3 1LU, Newcastle upon Tyne, UK. Electronic address:

The aim of this article is to argue that the ancient concept of akrasia can serve as the conceptual foundation and theoretical justification for a dual systems theory of addiction. Akrasia refers to acting against one's better judgement and thus to behaviour that agents know is bad for them and have previously resolved to abjure, addiction being seen as an extreme form of akrasia. In this way akrasia can provide the basis for accounts of addictive behaviour that stress its inconsistency over time and the great difficulty addicts experience in changing it. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112666DOI Listing

Ketamine's Dose Related Multiple Mechanisms of Actions: Dissociative Anesthetic to Rapid Antidepressant.

Behav Brain Res 2020 May 8:112631. Epub 2020 May 8.

University of Michigan Medical School, Department of Pharmacology, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA. Electronic address:

Ketamine induces safe and effective anesthesia and displays unusual cataleptic properties that gave rise to the term dissociative anesthesia. Since 1970, clinicians only utilized the drug as an anesthetic or analgesic for decades, but ketamine was found to have rapid acting antidepressant effects in 1990s. Accumulated evidence exhibits NMDAR antagonism may not be the only mechanism of ketamine. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112631DOI Listing

Increased functional connectivity in gambling disorder correlates with behavioural and emotional dysregulation: Evidence of a role for the cerebellum.

Behav Brain Res 2020 May 11;390:112668. Epub 2020 May 11.

Department of Health Promotion, Mother-Child Care, Internal Medicine and Medical Specialties of Excellence "G. D'Alessandro", University of Palermo, Palermo, Italy.

Gambling disorder (GD) is a psychiatric disease that has been recently classified as a behavioural addiction. So far, a very few studies have investigated the alteration of functional connectivity in GD patients, thus the concrete interplay between relevant function-dependent circuitries in such disease has not been comprehensively assessed. The aim of this research was to investigate resting-state functional connectivity in GD patients, searching for a correlation with GD symptoms severity. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112668DOI Listing

Gender differences in navigation performance are associated with differential theta and high-gamma activities in the hippocampus and parahippocampus.

Behav Brain Res 2020 May 17:112664. Epub 2020 May 17.

ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, NSW, 2109, Australia; Department of Cognitive Science, Macquarie University, Sydney, NSW, 2109, Australia. Electronic address:

Hippocampal rhythms are important for spatial navigation. This study examined whether gender differences in human navigation performance are associated with differences in hippocampal rhythms. We measured brain activities in males and females with whole-head magnetoencephalography (MEG), while they performed a virtual Morris water maze task. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112664DOI Listing

Liver hydrolysate prevents depressive-like behavior in an animal model of colitis: involvement of hippocampal neurogenesis via the AMPK/BDNF pathway.

Behav Brain Res 2020 May 17:112640. Epub 2020 May 17.

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.

Patients with inflammatory bowel disease (IBD) have higher rates of psychiatric pathology, including anxiety and depression. The dextran sulfate sodium (DSS)-treated mouse is a well-characterized animal model of colitis that exhibits IBD-like and depressive-like changes. A recent study found that phosphorylated (p-) adenosine monophosphate-activated protein kinase (AMPK) was associated with anti-inflammatory and antidepressant effects. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112640DOI Listing

The relationship between problem-solving ability and laterality in cats.

Behav Brain Res 2020 May 16:112691. Epub 2020 May 16.

Centro para o Conhecimento Animal, Algés, Portugal; Escola Superior Agrária de Elvas, Instituto Politécnico de Portalegre, Elvas, Portugal.

The association between hemispheric asymmetries and cognitive ability is one of the key areas of comparative laterality research. In several animal species, individual limb preferences correlate with perceptual, cognitive, or motor abilities, possibly by increasing dexterity of one limb and minimizing response conflicts between hemispheres. Despite this wealth of research, the association between laterality and cognitive abilities in the cat (Felis catus) is not well understood. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112691DOI Listing

Non-Pharmacological interventions for the anxiety in patients with dementia. A cross-over randomised controlled trial.

Behav Brain Res 2020 May 16;390:112617. Epub 2020 May 16.

1st Department of Neurology, Aristotle University of Thessaloniki, Makedonia, 3 Despere Street, Thessaloniki, Greece. Electronic address:

Background: Behavioural and Psychiatric Symptoms in dementia (BPSD) tend to be a crucial and big problem in dementia. Anxiety several times remains under-diagnosed because it is often considered to be a psychological response to cognitive decline. As only the 10 % of patients were correctly treated, the pharmacological treatment should be well- considered. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112617DOI Listing

Antidepressant-like and memory-enhancing effects of the N-type calcium channel blocker ziconotide in rats.

Behav Brain Res 2020 May 16;390:112647. Epub 2020 May 16.

Department of Pharmacology, Research Center of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

The lack of oral or injectable formulations of ziconotide (ω-conotoxin peptide), a novel analgesic agent, limits research on potential neurobehavioral protective properties of this substance, including antidepressant-like effects. Here we expose rats to a stress paradigm that induces depression and memory impairment to assess the effects of ziconotide treatment. Ziconotide was administered intracerebroventricular (i. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112647DOI Listing

Environmental enrichment reduces behavioural sensitization in mice previously exposed to toluene: The role of D1 receptors.

Behav Brain Res 2020 May 16:112624. Epub 2020 May 16.

Laboratorio Integrativo para el Estudio de Sustancias Inhalables Adictivas, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico.

It has been reported that environmental stimuli can positively influence addictive responses and the pharmacological effects of drugs of abuse. In this work, we evaluated the ability of environmental enrichment (EE) to attenuate addictive behaviours in mice after repeated exposure to toluene. We also analysed the role of D1 receptors (D1R) in animals chronically exposed to toluene and in those housed under EE. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112624DOI Listing

Motor system activation during motor imagery is positively related to the magnitude of cortical plastic changes following motor imagery training.

Behav Brain Res 2020 May 16:112685. Epub 2020 May 16.

Centre for Motor Control, Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON, Canada.

Motor imagery (MI) is a cognitive motor process wherein a person consciously imagines themselves performing a movement. Previous transcranial magnetic stimulation (TMS) studies have demonstrated that physical and observational training can elicit neuroplastic adaptations in the cortical representation of movement. It has been shown that these cortical adaptations can also occur following MI training. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112685DOI Listing

Non-androgenic testicular mediation of androphilia in male mice with global overexpression of androgen receptors.

Behav Brain Res 2020 May 16:112694. Epub 2020 May 16.

Department of Psychology, University of Toronto, Toronto, ON, Canada; Department of Cells and Systems Biology, University of Toronto, Toronto, ON, Canada. Electronic address:

Sexual attraction is robustly sexually differentiated among mammalian species. Gonadal androgens acting perinatally and in adulthood are required for male-typical preference for female sexual cues. Recent evidence suggests that at the high extent of AR signaling, male mice show an increased preference for same-sex odor cues. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112694DOI Listing

Rapid well-plate assays for motor and social behaviors in larval zebrafish.

Behav Brain Res 2020 May 16:112625. Epub 2020 May 16.

The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, 325035, PR China; Institute of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou, 325035, PR China. Electronic address:

Behavior phenotypes are a powerful means of uncovering subtle xenobiotic chemical impacts on vertebrate nervous system development. Rodents manifest complex and informative behavior phenotypes but are generally not practical models in which to screen large numbers of chemicals. Zebrafish recapitulate much of the behavioral complexity of higher vertebrates, develop externally and are amenable to assay automation. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112625DOI Listing

C57BL/6 substrain differences in formalin-induced pain-like behavioral responses.

Behav Brain Res 2020 May 16;390:112698. Epub 2020 May 16.

Department of Pharmacology and Toxicology and Translational Research Initiative for Pain and Neuropathy, Virginia Commonwealth University, Virginia Commonwealth University, Richmond, VA 23298-0613, USA.

Substantial evidence from preclinical models of pain suggests that basal and noxious nociceptive sensitivity, as well as antinociceptive responses to drugs, show significant heritability. Individual differences to these responses have been observed across species from rodents to humans. The use of closely related C57BL/6 inbred mouse substrains can facilitate gene mapping of acute nociceptive behaviors in preclinical pain models. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112698DOI Listing

Deficit in working memory and abnormal behavioral tactics in dopamine transporter knockout rats during training in the 8-arm maze.

Behav Brain Res 2020 May 16;390:112642. Epub 2020 May 16.

Institute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia; Saint Petersburg State University Hospital, Saint Petersburg State University, Saint Petersburg, Russia.

Understanding the role of the dopamine system in learning and memory processes is very important for uncovering central mechanisms underlying complex behavioral responses that can be impaired in patients with neuropsychiatric disorders caused by dopamine system dysfunction. One of the most useful animal models for dopaminergic dysregulation is the strain of dopamine transporter knockout (DAT-KO) rats that have no dopamine re-uptake and thus elevated extracellular dopamine levels. It is known that dopamine is involved in various cognitive processes such as learning, memory and attention. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112642DOI Listing

Effects of early life social experience on fear extinction and related glucocorticoid profiles - behavioral and neurochemical approaches in a rat model of PTSD.

Behav Brain Res 2020 May 16:112686. Epub 2020 May 16.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan; Department of Psychiatry, Cheng Hsin General Hospital, Taipei 11220, Taiwan; Laboratory of Cognitive Neuroscience, Department of Physiology, National Defense Medical Center, Taipei 11490, Taiwan. Electronic address:

People may agonize over an intrusive fear-inducing memory even when the traumatic event has passed, which is the principle manifestation of posttraumatic stress disorder (PTSD). However, many traumatized people do not present symptoms of PTSD, implying that certain hidden factors help those individuals to cope with the traumatic stress. Increasing evidence suggests that early life experience may serve as a predisposing factor in the development of PTSD. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112686DOI Listing

Impairment of nociceptive responses after neonatal anoxia correlates with somatosensory thalamic damage: A study in rats.

Behav Brain Res 2020 May 15;390:112690. Epub 2020 May 15.

Neurosciences Laboratory, Department of Anatomy, Institute of Biomedical Sciences, Universidade de São Paulo, Av. Professor Lineu Prestes, 2415, 05508-900, São Paulo, SP, Brazil. Electronic address:

Chronic neuropathic pain resulting from damage to the central or peripheral nervous system is a prevalent and debilitating condition affecting 7-18% of the population. Symptoms include spontaneous pain, dysesthesia, paresthesia, allodynia and hyperalgesia. The reported sensory symptoms are comorbid with behavioral disabilities such as insomnia and depression. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112690DOI Listing

Editorial to the special issue on time and the brain.

Authors:
Ekrem Dere

Behav Brain Res 2020 May 14;390:112679. Epub 2020 May 14.

Sorbonne Université, Institut de Biologie Paris-Seine (IBPS) Département UMR 8256, UFR des Sciences de la Vie, Campus Pierre et Marie Curie, Bâtiment B, étage 6, porte 601, 9 quai Saint Bernard, 75005 PARIS CEDEX, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2020.112679DOI Listing

Chrysin loaded lipid-core nanocapsules ameliorates neurobehavioral alterations induced by β-amyloid in aged female mice.

Behav Brain Res 2020 May 15;390:112696. Epub 2020 May 15.

Programa de Pós-Graduação em Bioquímica, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS 97500-970, Brazil.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a clinically and progressive loss of cognitive function, neuropsychiatric and behavioral disorders. Some studies showed that chrysin has antioxidant and anti-inflammatory properties. However, your bioavailability is relatively low. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112696DOI Listing

Pair housing, but not using a controlled reinforcer frequency procedure, attenuates the modulatory effect of probability presentation order on amphetamine-induced changes in risky choice.

Behav Brain Res 2020 May 15;390:112669. Epub 2020 May 15.

Department of Psychological Science, Northern Kentucky University, 1 Nunn Drive, Highland Heights, KY, 41099, USA.

Probability discounting is often measured with independent schedules. Independent schedules have several limitations, such as confounding preference for one alternative with frequency of reward presentation and generating ceiling/floor effects at certain probabilities. To address this potential caveat, a controlled reinforcer frequency schedule can be used, in which the manipulandum that leads to reinforcement is pseudo-randomly determined before each trial. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112669DOI Listing

Anti-nociceptive and antioxidant activity of betaine on formalin- and writhing tests induced pain in mice.

Behav Brain Res 2020 May 15;390:112699. Epub 2020 May 15.

Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Pain is a physiological response which is mediated via the central and peripheral nervous system. Betaine, is a methyl glycine derivative and a commonly used nutrient supplement. The main purpose of the current paper is to determine the possible anti-nociceptive and antioxidant activity and sedative effect of betaine in mice. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112699DOI Listing

Dorsal, but not ventral, hippocampal inactivation alters deliberation in rats.

Behav Brain Res 2020 May 14;390:112622. Epub 2020 May 14.

Laboratory of Cognitive Neuroscience, CNRS - Aix Marseille Université, Marseille, France. Electronic address:

When facing a choice at a decision point in a maze, rats often display hesitations, pauses and reorientations. Such "vicarious trial and error" (VTE) behavior is thought to reflect decision making about which choice option is best, and thus a deliberation process. Although deliberation relies on a wide neural network, the dorsal hippocampus appears to play a prominent role through both its neural activity and its dynamic interplay with other brain areas. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112622DOI Listing

Anxiolytic like effect of L-Carnitine in mice: Evidences for the involvement of NO-sGC-cGMP signaling pathway.

Behav Brain Res 2020 May 14:112689. Epub 2020 May 14.

Faculty of Pharmacy, DIT University, Dehradun, India. Electronic address:

L-Carnitine (LC) is an endogenous compound synthesized from the essential amino acids lysine and methionine. LC act as an antioxidant and modulates the levels of neurochemicals such as glutamate, GABA, NO etc. implicated in the regulation of anxiety and related behavior. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112689DOI Listing
May 2020
3.028 Impact Factor

Potential beneficial effects of caffeine administration in the neonatal period of an animal model of schizophrenia.

Behav Brain Res 2020 May 14:112674. Epub 2020 May 14.

Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, SP, Brazil; School of Medicine from Faculdade Israelita de Ciências da Saúde Albert Einstein, São Paulo, SP, Brazil. Electronic address:

Obstetric complications, like maternal hypertension and neonatal hypoxia, disrupt brain development, leading to psychiatry disorders later in life, like schizophrenia. The exact mechanisms behind this risk are not yet well known. Spontaneously hypertensive rats (SHR) are a well-established model to study neurodevelopment of schizophrenia since they exhibit behavioral alterations mimicking schizophrenia that can be improved with antipsychotic drugs. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112674DOI Listing

Increased amygdala and decreased hippocampus volume after schedule-induced polydipsia in high drinker compulsive rats.

Behav Brain Res 2020 May 14;390:112592. Epub 2020 May 14.

Department of Psychology & Health Research Centre (CEINSA), University of Almería, Almería, Spain. Electronic address:

Fronto-limbic structures and serotonin 2A receptors (5-HT) have been implicated in the pathophysiology and treatment of compulsive spectrum disorders. Schedule-Induced Polydipsia (SIP), characterized by the development of excessive drinking under intermittent food reinforcement schedules, is a valid preclinical model for studying the compulsive phenotype. In the present study, we explored the individual differences and effect of SIP in brain volume and 5-HT receptor binding in fronto-limbic structures in rats selected according to their compulsive drinking behavior. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112592DOI Listing

Adolescent substance use and functional connectivity between the ventral striatum and hippocampus.

Behav Brain Res 2020 May 12:112678. Epub 2020 May 12.

Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States; Merrill Palmer Skillman Institute for Child and Family Development, Detroit, MI, United States; Department of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI, United States; Department of Pharmaceutical Sciences, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI, United States.

Neurodevelopmental explanations for adolescent substance use have focused on heightened sensitivity of mesolimbic circuitry, centered on the ventral striatum (VS). Recent evidence suggests that, relative to adults, adolescents show a stronger link between reinforcement learning and episodic memory for rewarding outcomes and greater functional connectivity between the VS and hippocampus, which may reflect a heightened reward modulation of memory. However, a link between VS-hippocampal circuitry and adolescent substance use has yet to be established. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112678DOI Listing

Pictures of preterm infants elicit increased affective responses and reduced reward-motivation or perspective taking in the maternal brain.

Behav Brain Res 2020 May 12;390:112677. Epub 2020 May 12.

Child and Adolescent Studies, Utrecht University, Heidelberglaan 1, 3548 CS Utrecht, the Netherlands.

Preterm-birth increases the risk of several physical, cognitive, neuromotor, and psychosocial problems in children, and is also related to difficulties in the parent-child relationship. Research suggests that the development of early parent-child interactions in general is affected by deviations from typical infant facial characteristics, which may also be important in the case of small, preterm born infants. Therefore, we examined mothers' (N = 22, of whom 17 had no direct experience with preterm birth) neural responses to pictures of preterm and full-term infants using functional magnetic resonance imaging (fMRI). Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112677DOI Listing

Selective recall deficits for heterogeneous associations in detoxified individuals with alcohol use disorder.

Behav Brain Res 2020 May 12;390:112688. Epub 2020 May 12.

Clinical Neuropsychology, Neuropsychological Therapy Centre, Faculty of Psychology, Ruhr University Bochum, Bochum, Germany.

Aim: Alcohol use disorder (AUD) has been associated with recognition memory deficits. However, it remains unclear whether these deficits occur at the general recognition memory level or whether they selectively affect its subcomponents. Evidence suggests that recognition memory deficits may vary according to the heterogeneity of memory stimuli. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112688DOI Listing

Effects of a trace amine-associated receptor 1 agonist RO 5263397 on ethanol-induced behavioral sensitization.

Behav Brain Res 2020 May 12;390:112641. Epub 2020 May 12.

Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, United States. Electronic address:

Background: Alcohol dependence is a chronic and severe health problem which puts a heavy burden on society. Alcohol activates mesolimbic dopamine circuity to achieve its reinforcing effect. While TAAR1 is critically involved in the modulation of dopamine, there is little evidence indicating that TAAR1 could play a role in behavioral effects of ethanol. Read More

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Memory reacquisition deficit: chicks fail to relearn pharmacologically disrupted associative response.

Behav Brain Res 2020 May 11:112695. Epub 2020 May 11.

P. K. Anokhin Research Institute of Normal Physiology, 125315, Moscow, Russia; Lomonosov Moscow State University, 119991, Moscow, Russia.

It is generally assumed that if memory is disrupted by pharmacological inhibitors during its consolidation, it can be later acquired afresh. In our experiments, we trained day-old chicks in a one-trial passive avoidance task and interfered with memory formation using protein synthesis inhibitor anisomycin or NMDA receptor antagonist MK-801. Second training was then given to amnestic animals with either the same conditioning stimulus (retraining) or a new one (novel training). Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112695DOI Listing

The dorsal subiculum is required for contextual fear conditioning consolidation in rats.

Behav Brain Res 2020 May 12;390:112661. Epub 2020 May 12.

Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil. Electronic address:

The hippocampal formation has a well-known role in contextual fear conditioning. The dorsal subiculum connects the hippocampus to the entorhinal cortex through pathways that seemingly rely on NMDA-dependent synaptic plasticity. The role of the dorsal subiculum in contextual fear conditioning retrieval, but not acquisition, has been previously reported. Read More

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CaMKII is activated in opioid induced Conditioned Place Preference, but αCaMKII Thr286 autophosphorylation is not necessary for its establishment.

Behav Brain Res 2020 May 11:112676. Epub 2020 May 11.

Section for Drug Abuse Research, Oslo, Norway. Electronic address:

Activation of calcium/calmodulin-dependent protein kinase II (CaMKII), particularly its α isoform, is known to be important for neuronal processes central for learning and memory and has also been implicated in the maladaptive learning involved in drug addiction.Thr286 autophosphorylation of αCaMKII has been shown to be indispensable for establishment of cocaine-induced CPP (Easton et al., 2014). Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112676DOI Listing

Ketamine and rapid acting antidepressants: Are we ready to cure, rather than treat depression?

Behav Brain Res 2020 May 11;390:112628. Epub 2020 May 11.

National Center for PTSD - Clinical Neuroscience Division, US Department of Veterans Affairs, West Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Depression is a leading cause of disability, with often chronic course of illness and high treatment resistance in a large proportion of patients. In the current short perspective paper, we present evidence supporting the presence of synaptic-based chronic stress pathology (CSP) in depression and across a number of psychiatric disorders. We summarize the synaptic connectivity model of CSP, and briefly review related preclinical and clinical evidence, while providing appropriate references for more comprehensive reviews and alternative models. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112628DOI Listing

Fish-oil supplementation decreases Indoleamine-2,3-Dioxygenase expression and increases hippocampal serotonin levels in the LPS depression model.

Behav Brain Res 2020 May 12;390:112675. Epub 2020 May 12.

Departamento de Fisiologia, Universidade Federal do Paraná, Curitiba, PR, Brazil.

Aim: To test the hypothesis that the antidepressant-like effect of omega-3 polyunsaturated fatty acids is related to the Indoleamine-2,3-Dioxygenase (IDO) inhibition.

Methods: Animals were supplemented for 50 days with 3.0 g/kg of Fish Oil (FO) or received water (Control group - C), via gavage. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112675DOI Listing

Anorexia induces a microglial associated pro-inflammatory environment and correlates with neurodegeneration in the prefrontal cortex of young female rats.

Behav Brain Res 2020 May 6:112606. Epub 2020 May 6.

Departamento de Neurobiología Celular y Molecular, Mexico. Electronic address:

Dehydration-Induced Anorexia (DIA) is a murine model that reproduces weight loss and avoidance of food, despite its availability. The prefrontal cortex (PFC) integrates sensory inputs and updates associative learning to promote (hunger) or inhibit (satiety) food-seeking behavior. In this study we tested if anorexia induces a pro-inflammatory environment associated with microglia in the medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC), specific subregions of the PFC involved in appetite. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112606DOI Listing

Maternal exercise during gestation and lactation decreases high-fat diet preference by altering central reward system gene expression in adult female offspring from high-fat fed dams.

Behav Brain Res 2020 May 7;390:112660. Epub 2020 May 7.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address:

Exposure to maternal high-fat (HF) diet during gestation and lactation alters adult offspring's feeding behavior and diet preference. However, the impact of maternal exercise on offspring's diet preference and reward system development is less studied. In this study, we investigate the effect of perinatal maternal exercise on the development of diet preference, dopamine- and opioid-related gene expression in the central reward system in female offspring from HF-fed Sprague-Dawley rat dams. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112660DOI Listing

A genetic profile of oxytocin receptor improves moral acceptability of outcome-maximizing harm in male insurance brokers.

Behav Brain Res 2020 May 5:112681. Epub 2020 May 5.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Electronic address:

In recent years, conflicting findings have been reported in the scientific literature about the influence of dopaminergic, serotonergic and oxytocinergic gene variants on moral behavior. Here, we utilized a moral judgment paradigm to test the potential effects on moral choices of three polymorphisms of the Oxytocin receptor (OXTR): rs53576, rs2268498 and rs1042770. We analyzed the influence of each single polymorphism and of genetic profiles obtained by different combinations of their genotypes in a sample of male insurance brokers (n = 129), as compared to control males (n = 109). Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112681DOI Listing