Behav Pharmacol 2017 Sep;28(6):420-427
aDepartment of Neuroscience, Guilan Road Trauma Research Center, Poursina Hospital, Guilan University of Medical Sciences bDepartment of Neurosurgery, Neuroscience Research Center, Poursina Hospital, School of Medicine, Guilan University of Medical sciences, Rasht cIntracellular Recording Laboratory, Department of Neuroscience, Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences dSchool of Pharmacy and Pharmaceutical Sciences, Kerman University of Medical Sciences, Kerman, Iran eDepartment of Biochemistry and Molecular & Cellular Biology, School of Medicine, Georgetown University, Washington, District of Columbia, USA.
Nitric oxide (NO) and angiotensin (AT) receptors have demonstrated well-established interactions in various physiological phenomena. AT1 receptors can play a part in stress-induced activation of the hypothalamic-pituitary-adrenal axis; also, angiotensinergic neurotransmission plays a pivotal role in stress-evoked physiological responses. On the basis of the stress-modulating characteristics of NO, AT1, and AT2 receptors, the present study evaluated the roles of NO and AT1 receptors in the attenuation of stress-induced anxiety-like behaviors after administration of losartan, an AT1 antagonist. Read More