2,199 results match your criteria Behavioural Pharmacology[Journal]


Social environment modulates anxiogenic effects of caffeine in zebrafish.

Behav Pharmacol 2018 Jun 20. Epub 2018 Jun 20.

Department of Mechanical and Aerospace Engineering, Tandon School of Engineering, 6 MetroTech Center, New York University, Brooklyn, New York, USA.

Zebrafish has recently become a species of choice in a number of preclinical studies to examine whether and how psychoactive compounds modulate individual and social behaviors. Here, we sought to contribute an improved understanding of the effects of caffeine, a well-known anxiogenic compound, on the swimming activity and the collective response of zebrafish. To investigate how the social environment influences individual response to acute caffeine treatment, we measured the behavior of a caffeine-treated subject swimming in isolation or in the presence of a group of untreated conspecifics. Read More

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June 2018
1 Read

Response-inhibition capacity in spontaneously hypertensive and Wistar rats: acquisition of fixed minimum interval performance and responsiveness to D-amphetamine.

Behav Pharmacol 2018 Jun 5. Epub 2018 Jun 5.

Department of Psychology, Universidad Nacional Autónoma de México, México City, México.

Reduced response-inhibition capacity is a defining feature of attention-deficit hyperactivity disorder. The fixed minimum interval (FMI) schedule has been systematically validated to assess such capacity in rats. On each FMI trial, the first lever press initiates an inter-response time (IRT); a potentially consummatory response terminates the IRT; only IRTs longer than a target interval result in access to food. Read More

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June 2018
1 Read

Pharmacokinetic and pharmacodynamic analysis of d-amphetamine in an attention task in rodents.

Behav Pharmacol 2018 Jun 2. Epub 2018 Jun 2.

National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA.

Amphetamine is a common therapeutic agent for alleviating the core symptoms associated with attention-deficit hyperactivity disorder (ADHD) in children and adults. The current study used a translational model of attention, the five-choice serial reaction time (5-CSRT) procedure with rats, to examine the time-course effects of d-amphetamine. Effects of different dosages of d-amphetamine were related to drug-plasma concentrations, fashioned after comprehensive pharmacokinetic/pharmacodynamic assessments that have been employed in clinical investigations. Read More

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June 2018
1 Read

Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease.

Behav Pharmacol 2018 May 25. Epub 2018 May 25.

Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University.

The development of Parkinson's disease (PD) involves the degeneration of dopaminergic neurons caused by oxidative stress. Accumulating clinical evidence indicates that high blood levels of uric acid (UA), an intrinsic antioxidative substance, are associated with reduced risk of PD. However, this hypothesis has not been confirmed by in-vivo experiments. Read More

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Sex still matters: has the prevalence of male-only studies of drug effects on rodent behaviour changed during the past decade?

Authors:
Robert N Hughes

Behav Pharmacol 2018 May 25. Epub 2018 May 25.

Department of Psychology, University of Canterbury, Christchurch, New Zealand.

During the past 10 years, for a number of biomedical disciplines, including behavioural pharmacology, there have been appeals to include both sexes in animal studies of processes that are not sex specific. In 2007, a survey of experimental studies of drug or other chemical effects on rodent behaviour, published in five prominent journals over 20 months (February 2005 to September 2006, inclusive), revealed that 85% of these conducted with rats and 78% of these conducted with mice involved males only. This was in spite of the evidence of sex differences in responsiveness to an increasing number of compounds. Read More

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Rapid assessment of the dose-response relationship of methamphetamine using the progressive-dosing procedure.

Authors:
Shigeru Watanabe

Behav Pharmacol 2018 May 29. Epub 2018 May 29.

Department of Psychology, Keio University, Tokyo, Japan.

This paper describes a new method to rapidly obtain dose-response curves for a drug with rewarding properties using the conditioned place preference protocol. In the usual single-dosing procedure, different animals receive single, varying doses. Thus, a large number of animals are required to generate a curve. Read More

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Neuroprotective effects of Danshensu in Parkinson's disease mouse model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Behav Pharmacol 2018 May 29. Epub 2018 May 29.

Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), School of Pharmacy, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, Shandong, People's Republic of China.

Parkinson's disease (PD) causes major changes in dopaminergic neurons of the brain, resulting in motor symptoms in older adults. A previous study showed that Danshensu alleviates the cognitive decline by attenuating neuroinflammation. In the present study, we investigated the neuroprotective effect of Danshensu in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. Read More

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May 2018
1 Read

SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization.

Behav Pharmacol 2018 May 29. Epub 2018 May 29.

Discovery Research, Suven Life Sciences Ltd, Hyderabad, India.

Research in Alzheimer's disease is going through a big turnaround. New palliative therapies are being reconsidered for the effective management of disease because of setbacks in the development of disease-modifying therapies. Serotonin 6 (5-HT6) receptor has long been pursued as a potential target for the symptomatic treatment of Alzheimer's disease. Read More

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Role of D1-like and D2-like dopamine receptors within the ventral tegmental area in stress-induced and drug priming-induced reinstatement of morphine seeking in rats.

Behav Pharmacol 2018 Apr 20. Epub 2018 Apr 20.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences.

The ventral tegmental area (VTA) as a major source of dopamine neurons projecting to cortical and limbic regions has a crucial role in reward as well as stress processes. Dopamine is a predominant neurotransmitter in the reward system, which plays an important role in both drug priming-induced and cue-induced reinstatement of cocaine and heroin seeking. It has been shown that this neurotransmitter has a role in stress-induced relapse to drug seeking. Read More

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April 2018
5 Reads

Cross-tolerance between nitric oxide synthase inhibition and atypical antipsychotics modify nicotinamide-adenine-dinucleotide phosphate-diaphorase activity in mouse lateral striatum.

Behav Pharmacol 2018 Apr 16. Epub 2018 Apr 16.

Center for Mathematics, Computation and Cognition.

Previous research indicates that the subchronic administration of NG-nitro-L-arginine (L-NOARG) produces tolerance to haloperidol-induced catalepsy in Swiss mice. The present study aimed to further investigate whether intermittent subchronic systemic administration of L-NOARG induces tolerance to the cataleptic effects of haloperidol as well as olanzapine or clozapine (Clz) in C57Bl mice after subchronic administration for 5 consecutive days. Striatal FosB protein expression was measured in an attempt to gain further insights into striatal mechanisms in antipsychotic-induced extrapyramidal symptoms side effects. Read More

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April 2018
1 Read

Effect of pioglitazone and simvastatin in lipopolysaccharide-induced amyloidogenesis and cognitive impairment in mice: possible role of glutamatergic pathway and oxidative stress.

Behav Pharmacol 2018 Apr 13. Epub 2018 Apr 13.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Giza, Egypt.

Neuroinflammation and β-amyloid (Aβ) deposition in the brain are well known characteristics of neurodegeneration. Diabetes and hypercholesterolemia are the main risk factors leading to memory loss and cognitive impairment. Recently, it was found that statins and thiazolidinediones have promising anti-inflammatory and neuroprotective effects that could delay neurodegeneration and neuronal loss in diabetic and hypercholesterolemic patients. Read More

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April 2018
1 Read

A behavioral economic analysis of the value-enhancing effects of nicotine and varenicline and the role of nicotinic acetylcholine receptors in male and female rats.

Behav Pharmacol 2018 Apr 9. Epub 2018 Apr 9.

Department of Psychology, University of Nebraska, Lincoln, Nebraska, USA.

Reinforcement value enhancement by nicotine of non-nicotine rewards is believed to partially motivate smoking behavior. Recently, we showed that the value-enhancing effects of nicotine are well characterized by reinforcer demand models and that the value-enhancing effects of the smoking-cessation aid bupropion (Zyban) are distinct from those of nicotine and differ between the sexes. The present study evaluated potential sex differences in the enhancement effects of nicotine and varenicline (Chantix) using a reinforcer demand methodology. Read More

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April 2018
1 Read

Effects of daily morphine treatment on impulsivity in rats responding under an adjusting stop-signal reaction time task.

Behav Pharmacol 2018 Mar 27. Epub 2018 Mar 27.

Departments of Pharmacology.

Opioids can enhance delay discounting and premature responding under attentional tasks that might reflect increased impulsivity; although it is not clear whether repeated opioid administration alters behavioral inhibition. Effects of morphine and amphetamine were determined before, during, and after daily morphine administration in rats responding under a stop-signal reaction time task, measuring behavioral inhibition and motor impulsivity. Rats (n=5) completed a two-response sequence to earn food. Read More

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March 2018
2 Reads

Co-administration of amphetamine with alcohol results in decreased alcohol withdrawal severity in adolescent rats.

Behav Pharmacol 2018 Mar 27. Epub 2018 Mar 27.

Department of Biology, Monmouth University, West Long Branch, New Jersey, USA.

Simultaneous use of stimulants and alcohol is a growing problem, particularly among older adolescents already prone to binge alcohol consumption. Adolescent rats consume high levels of alcohol when administered in a liquid diet and develop a strong alcohol withdrawal syndrome. We exploited this system to administer amphetamine in combination with alcohol and to test the effect of co-administration of amphetamine on alcohol withdrawal-induced hypoactivity and overall withdrawal severity. Read More

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March 2018
2 Reads

Sex-specific differences in cannabinoid-induced extracellular-signal-regulated kinase phosphorylation in the cingulate cortex, prefrontal cortex, and nucleus accumbens of Lister Hooded rats.

Behav Pharmacol 2018 Mar 27. Epub 2018 Mar 27.

Department of Biomedical Sciences, Centre of Excellence 'Neurobiology of Addiction', University of Cagliari.

Sex-dependent differences have been consistently described in cannabinoid addiction research. In particular, we recently reported that female Lister Hooded rats display greater self-administration of the cannabinoid CB1 receptor agonist WIN55,212-2 (WIN) and stronger reinstatement of cannabinoid-seeking behavior than males. Cannabinoids modulate the phosphorylation of the extracellular-signal-regulated kinase (ERK) pathway, leading to various forms of plasticity-related learning that likely affect operant behavior. Read More

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March 2018
1 Read

Repeated forced-swimming test in intact female rats: behaviour, oestrous cycle and enriched environment.

Behav Pharmacol 2018 Mar 27. Epub 2018 Mar 27.

Department of Physiological Sciences.

Psychopharmacology used animal models to study the effects of drugs on brain and behaviour. The repeated forced-swimming test (rFST), which is used to assess the gradual effects of antidepressants on rat behaviour, was standardized only in males. Because of the known sex differences in rats, experimental conditions standardized for males may not apply to female rats. Read More

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March 2018
1 Read

Fatty acid-binding proteins 5 and 7 gene deletion increases sucrose consumption and diminishes forced swim immobility time.

Behav Pharmacol 2018 Mar 21. Epub 2018 Mar 21.

Research Institute on Addictions, University at Buffalo, Buffalo.

Inhibition and genetic deletion of fatty acid-binding proteins (FABPs) 5 and 7 have been shown to increase the levels of the endocannabinoid anandamide as well as the related N-acylethanolamine's palmitoylethanolamide and oleoylethanolamide. This study examined the role of these FABPs on forced-swim (FS) behavior and on sucrose consumption in two experiments: (experiment 1) using wild-type (WT) mice treated with the FABP inhibitor SBFI26 or vehicle and (experiment 2) using WT and FABP5/7 deficient mice. Results from experiment 1 showed that acute treatment with SBFI26 did not have any effect on sucrose intake or FS behavior in mice. Read More

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March 2018
3 Reads

Potential learning and memory disruptors and enhancers in a simple, 1-day operant task in mice.

Behav Pharmacol 2018 Mar 21. Epub 2018 Mar 21.

Department of Pharmaceutical Sciences, School of Pharmacy.

The objective of this study was to develop a rapid, 1-day learning and memory assay in mice that is sensitive to the effects of compounds that could impair or enhance acquisition and retrieval. Swiss-Webster, male mice were placed in experimental chambers for a 1-h acquisition session with an intermittent, audible tone. If a nose-poke response occurred during the tone, an Ensure water solution was presented. Read More

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March 2018
1 Read

Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance.

Behav Pharmacol 2018 Mar 20. Epub 2018 Mar 20.

Department of Neuropsychiatry.

Depression is the disease of the modern era. The lack of response to the available antidepressants, which were developed on the basis of the monoaminergic deficit hypothesis of depression, has encouraged scientists to think about new mechanisms explaining the pathogenesis of depression. In this context, the inflammatory theory has emerged to clarify many aspects of depression that the previous theories have failed to explain. Read More

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March 2018
1 Read

Perinatal exposure to venlafaxine leads to lower anxiety and depression-like behavior in the adult rat offspring.

Behav Pharmacol 2018 Mar 20. Epub 2018 Mar 20.

Department of Developmental and Behavioral Toxicology, Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine.

Depression during pregnancy and in the post-partum period is a growing health issue. Venlafaxine, a representative of serotonin and noradrenaline reuptake inhibitors, is used to treat a wide spectrum of mood disorders. However, the limited number of prenatal and perinatal studies raises the question about the long-term consequences of venlafaxine therapy. Read More

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March 2018
3 Reads

Pilot investigation: randomized-controlled analog trial for alcohol and tobacco smoking co-addiction using contingency management.

Behav Pharmacol 2018 Mar 20. Epub 2018 Mar 20.

Department of Medical Education and Clinical Sciences, Elson S. Floyd College of Medicine.

Contingency management (CM) is associated with decreases in off-target drug and alcohol use during primary target treatment. The primary hypothesis for this trial was that targeting alcohol use or tobacco smoking would yield increased abstinence in the opposite, nontargeted drug. We used a 2 [CM vs. Read More

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March 2018
3 Reads

Exposure to opiates in male adolescent rats alters pain perception in the male offspring.

Behav Pharmacol 2018 Apr;29(2 and 3 - Special Issue):255-260

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

During the past decades, the use/misuse of opioids has increased dramatically among adolescent population. It is now well acknowledged that various morphological and physiological changes occur in the brain during adolescence. During this critical period, brain development and maturation could be affected by several factors including stress, drug abuse, nutritional status, etc. Read More

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April 2018
1 Read

Early signs of colonic inflammation, intestinal dysfunction, and olfactory impairments in the rotenone-induced mouse model of Parkinson's disease.

Behav Pharmacol 2018 Apr;29(2 and 3 - Special Issue):199-210

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil.

The factors that trigger the pathophysiology of Parkinson's disease (PD) are unknown. However, it is suggested that environmental factors, such as exposure to pesticides, play an important role, in addition to genetic predisposition and aging. Early signs of PD can appear in the gastrointestinal (GI) tract and in the olfactory system, preceding the onset of motor impairments by many years. Read More

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April 2018
4 Reads

Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer.

Behav Pharmacol 2018 Apr;29(2 and 3 - Special Issue):165-180

Neuropsychopharmacology Laboratory.

Both depression and cancer are related to a dysregulation of inflammatory and immune pathways. Indeed, depression is associated with increased expression of interferon-γ, interleukin-1β, and tumor necrosis factor α (TNF-α). In contrast, reductions of the activity of major histocompatibility complex protein molecules - class I and class II and natural killer cells are also observed. Read More

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April 2018
4 Reads

Heart and soul: heart rate variability and major depression.

Behav Pharmacol 2018 Apr;29(2 and 3 - Special Issue):152-164

Victoria University of Wellington, Behavioural Neurogenetics Group, Wellington, New Zealand.

There is a bidirectional relationship between affective disorders and cardiovascular abnormalities, often described as a downward spiral, whereas major depressive disorders (MDD, and anxiety disorders) significantly increase the risk of developing cardiovascular diseases (CVD); CVD are also associated with increased risk of developing MDD (and anxiety disorders). Moreover, the prognosis and progression of CVD is significantly worsened in the presence of MDD. Heart rate variability (HRV) has often been suggested as a potential mediator in this comorbidity. Read More

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April 2018
1 Read

Heart-rate variability: a biomarker to study the influence of nutrition on physiological and psychological health?

Behav Pharmacol 2018 Apr;29(2 and 3 - Special Issue):140-151

Department of Psychology, University of Wales Swansea, Swansea, Wales, UK.

As the influence of diet on health may take place over a period of decades, there is a need for biomarkers that help to identify those aspects of nutrition that have either a positive or a negative influence. The evidence is considered that heart-rate variability (HRV) (the time differences between one beat and the next) can be used to indicate the potential health benefits of food items. Reduced HRV is associated with the development of numerous conditions for example, diabetes, cardiovascular disease, inflammation, obesity and psychiatric disorders. Read More

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April 2018
1 Read

Painful neurotrophins and their role in visceral pain.

Behav Pharmacol 2018 Apr;29(2 and 3 - Special Issue):120-139

Associated Unit I+D+i to the Institute of Medicinal Chemistry (IQM).

Beyond their well-known role in embryonic development of the central and peripheral nervous system, neurotrophins, particularly nerve growth factor and brain-derived neurotrophic factor, exert an essential role in pain production and sensitization. This has mainly been studied within the framework of somatic pain, and even antibodies (tanezumab and fasinumab) have recently been developed for their use in chronic somatic painful conditions, such as osteoarthritis or low back pain. However, data suggest that neurotrophins also exert an important role in the occurrence of visceral pain and visceral sensitization. Read More

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April 2018
5 Reads

Behavioural pharmacology and brain-body signalling processes.

Authors:

Behav Pharmacol 2018 Apr;29(2 and 3 - Special Issue):99-101

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April 2018
1 Read

Acute food deprivation separates motor-activating from anxiolytic effects of caffeine in a rat open field test model.

Authors:
Daniela Schulz

Behav Pharmacol 2018 Mar 14. Epub 2018 Mar 14.

Department of Psychology, Yeditepe University, Istanbul, Turkey.

Similar doses of caffeine have been shown to produce either anxiolytic or anxiogenic effects in rats. The reasons for these conflicting results are not known. We hypothesized that food deprivation stress interacts with the stimulant effects of caffeine to increase anxiety-like behavior. Read More

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March 2018
3 Reads

Psilocin and ketamine microdosing: effects of subchronic intermittent microdoses in the elevated plus-maze in male Wistar rats.

Behav Pharmacol 2018 Mar 13. Epub 2018 Mar 13.

National Institute of Mental Health CZ, Klecany.

Short-term moderate doses of serotonergic and dissociative hallucinogens can be useful in the treatment of anxiety. Recently, a trend has developed for long-term intermittent 'microdosing' (usually one-tenth of a 'full' active dose), with reports of long-lasting relief from anxiety and related disorders; however, there is no scientific evidence for the efficacy of therapeutic microdosing nor to show its lasting effects. The objective of this study was to test for lasting effects on anxiety in rats after microdosing with ketamine or psilocin. Read More

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March 2018
4 Reads

Effects on brain-derived neurotrophic factor signalling of chronic mild stress, chronic risperidone and acute intracranial dopamine receptor challenges.

Behav Pharmacol 2018 Mar 13. Epub 2018 Mar 13.

Department of Psychology, Swansea University, Swansea, UK.

We have previously reported the effects of intracranial injections of dopamine D1, D2 and D3 ligands in animals subjected to the Novel Object Recognition (NOR) test following exposure to chronic mild stress (CMS) and chronic treatment with risperidone (RSP). Here, we present some molecular biological data from the same animals. It was predicted that brain-derived neurotrophic factor (BDNF) signalling in the prefrontal cortex (PFC) would reflect behavioural performance, implying an increase following acute administration of a D2 agonist or a D3 antagonist, blockade of this effect by CMS and its restoration by chronic RSP. Read More

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March 2018
3 Reads

Probiotics in digestive, emotional, and pain-related disorders.

Behav Pharmacol 2018 Apr;29(2 and 3 - Special Issue):103-119

Department of Nursing, Physiotherapy and Medicine, University of Almería, Almería.

In recent years, interest in the relationship between gut microbiota and disease states has grown considerably. Indeed, several strategies have been employed to modify the microbiome through the administration of different diets, by the administration of antibiotics or probiotics, or even by transplantation of feces. In the present manuscript, we focus specifically on the potential application of probiotics, which seem to be a safe strategy, in the management of digestive, pain, and emotional disorders. Read More

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April 2018
3 Reads

Estradiol suppresses ingestive response evoked by activation of 5-HT1A receptors in the lateral hypothalamus of ovariectomized rats.

Behav Pharmacol 2018 Mar 8. Epub 2018 Mar 8.

Department of Physiological Sciences, Centre of Biological Sciences, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil.

The present study investigated the effects of estradiol (E2) on ingestive behavior after activation of 5-HT1A receptors in the lateral hypothalamus (LH) of female rats habituated to eat a wet mash diet. Ovariectomized rats treated with corn oil (OVX) or estradiol cypionate (OVX+E) received local injections into the LH of vehicle or an agonist of 5-HT1A receptors, 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT; at a dose of 6 nmol). To determine the involvement of these receptors in food intake, some animals were pretreated with N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexane carboxamide maleate (WAY-100635, a 5-HT1A receptor full antagonist, at a dose of 0. Read More

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March 2018
1 Read

Dissociation between morphine-induced spinal gliosis and analgesic tolerance by ultra-low-dose α2-adrenergic and cannabinoid CB1-receptor antagonists.

Behav Pharmacol 2018 Apr;29(2 and 3 - Special Issue):241-254

Department of Biomedical and Molecular Sciences, Faculty of Health Sciences.

Long-term use of opioid analgesics is limited by tolerance development and undesirable adverse effects. Paradoxically, spinal administration of ultra-low-dose (ULD) G-protein-coupled receptor antagonists attenuates analgesic tolerance. Here, we determined whether systemic ULD α2-adrenergic receptor (AR) antagonists attenuate the development of morphine tolerance, whether these effects extend to the cannabinoid (CB1) receptor system, and if behavioral effects are reflected in changes in opioid-induced spinal gliosis. Read More

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April 2018
1 Read

Microinjection of the mGluR2/3 agonist, LY379268, into the nucleus accumbens attenuates extinction latencies and the reinstatement of morphine-induced conditioned place preference in rats.

Behav Pharmacol 2018 Feb 16. Epub 2018 Feb 16.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences.

Previous studies indicate that metabotropic glutamate receptor type 2/3 (mGluR2/3) has a key role in the rewarding properties of morphine-induced conditioning place preference (CPP). Group II mGluR2/3 agonists are offered as a drug addiction treatment. The nucleus accumbens (NAc), which is one of the important areas involved in the reward circuitry, also expresses these receptors. Read More

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February 2018
1 Read

Medication overuse headache following repeated morphine, but not [INCREMENT]9-tetrahydrocannabinol administration in the female rat.

Behav Pharmacol 2018 Feb 16. Epub 2018 Feb 16.

Department of Integrative Physiology and Neuroscience, Graduate Program in Neuroscience.

The potential of [INCREMENT]-tetrahydrocannabinol (THC) as a treatment for migraine depends on antinociceptive efficacy with repeated administration. Although morphine has good antinociceptive efficacy, repeated administration causes medication overuse headache (MOH) - a condition in which the intensity/frequency of migraine increases. The present study compared the effect of repeated morphine or THC administration on the magnitude and duration of migraine-like pain induced by a microinjection of allyl isothiocyanate (AITC) onto the dura mater of female rats. Read More

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February 2018
1 Read

Strain differences in the susceptibility to the gut-brain axis and neurobehavioural alterations induced by maternal immune activation in mice.

Behav Pharmacol 2018 Apr;29(2 and 3 - Special Issue):181-198

APC Microbiome Institute.

There is a growing realization that the severity of the core symptoms of autism spectrum disorders and schizophrenia is associated with gastrointestinal dysfunction. Nonetheless, the mechanisms underlying such comorbidities remain unknown. Several genetic and environmental factors have been linked to a higher susceptibility to neurodevelopmental abnormalities. Read More

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April 2018
2 Reads

Effects of the active constituents of Crocus sativus L. crocins and their combination with memantine on recognition memory in rats.

Behav Pharmacol 2018 Feb 16. Epub 2018 Feb 16.

Laboratory of Chemistry, Department of Food Science and Human Nutrition, School of Food Biotechnology and Development, Agricultural University of Athens, Athens, Greece.

Crocus sativus L., is a plant cultivated in many countries of the world. Crocins are among the active constituents of C. Read More

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February 2018
2 Reads

Disulfiram attenuates morphine or methadone withdrawal syndrome in mice.

Behav Pharmacol 2018 Feb 16. Epub 2018 Feb 16.

Departments of Pharmacodynamics.

Taking opioids is often accompanied by the development of dependence. Unfortunately, treatment of opioid dependence is difficult, particularly because of codependence - for example, on alcohol or other drugs of abuse. In the presented study, we analyzed the potential influence of disulfiram, a drug used to aid the management of alcoholism, on opioid abstinence syndrome, which occurs as a result of opioid withdrawal. Read More

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February 2018
1 Read

Corticosterone impairs flexible adjustment of spatial navigation in an associative place-reward learning task.

Behav Pharmacol 2018 Jun;29(4):351-364

Swammerdam Institute for Life Sciences.

Cognitive challenges are often accompanied by a discharge of stress hormones, which in turn modulate multiple brain areas. Among these, the medial temporal lobe and the prefrontal cortex are critically involved in high-order cognitive functions such as learning, memory, and decision-making. Previous studies assessing the effects of corticosterone on spatial memory found an increase or a decrease in performance depending on the timing of stress hormone discharge relative to the behavioral task. Read More

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June 2018
3 Reads

Lack of paclitaxel effects on intracranial self-stimulation in male and female rats: comparison to mechanical sensitivity.

Behav Pharmacol 2018 Apr;29(2 and 3 - Special Issue):290-298

Departments of Pharmacology and Toxicology.

Paclitaxel is a cancer chemotherapy with adverse effects that include peripheral neuropathy, neuropathic pain, and depression of behavior and mood. In rodents, hypersensitive paw-withdrawal reflexes from mechanical stimuli serve as one common measure of paclitaxel-induced pain-related behavior. This study tested the hypothesis that paclitaxel would also depress rates of positively reinforced operant responding as a measure of pain-related behavioral depression. Read More

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April 2018
4 Reads

Choline acetyltransferase and TrkA expression, as well as the improvement in cognition produced by E2 and P4 in ovariectomized rats, are blocked by ICI 182 780 and RU486.

Behav Pharmacol 2018 Jan 9. Epub 2018 Jan 9.

Escuela Superior de Medicina, Instituto Politécnico Nacional.

Treatment with 17-β estradiol and progesterone improves the performance of ovariectomized rats in an autoshaping learning task, representing cognitive improvement. To test whether this is attributable to genomic mechanisms, the antiestrogen ICI 182 780 or antiprogesterone RU486 was injected into ovariectomized animals primed previously with estrogen or progesterone, respectively. Compared with the vehicle control, each hormone administered alone produced an elevated expression of choline acetyltransferase and TrkA, along with an improvement in performance on the behavioral test. Read More

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January 2018
2 Reads

Enhanced antinociception with repeated microinjections of apomorphine into the periaqueductal gray of male and female rats.

Behav Pharmacol 2018 Apr;29(2 and 3 - Special Issue):234-240

Department of Psychology, Washington State University Vancouver.

Dopamine neurons in the ventrolateral periaqueductal gray (PAG) have been reported to contribute to antinociception. The objective of this study was to determine how this dopamine-mediated antinociception differs from what is known about morphine-induced antinociception. Microinjection of the dopamine receptor agonist apomorphine into the PAG produced a dose-dependent increase in hot plate latency and a decrease in open field activity that was greater in male than in female rats. Read More

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April 2018
4 Reads

Additive and subadditive antiallodynic interactions between μ-opioid agonists and N-methyl D-aspartate antagonists in male rhesus monkeys.

Behav Pharmacol 2018 Feb;29(1):41-52

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.

μ-Opioid agonists are clinically effective analgesics, but also produce undesirable effects such as sedation and abuse potential that limit their clinical utility. Glutamatergic systems also modulate nociception and N-methyl D-aspartate (NMDA) receptor antagonists have been proposed as one useful adjunct to enhance the therapeutic effects and/or attenuate the undesirable effects of μ-opioid agonists. Whether NMDA antagonists enhance the antiallodynic effects of μ-agonists in preclinical models of thermal hypersensitivity (i. Read More

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February 2018
3 Reads

Involvement of adenosine triphosphate-sensitive potassium channels in the neuroprotective activity of hydrogen sulfide in the 6-hydroxydopamine-induced animal model of Parkinson's disease.

Behav Pharmacol 2018 Jun;29(4):336-343

Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran.

Studies have shown that hydrogen sulfide (H2S) exerts a neuroprotective effect and may have a therapeutic value for treating neurodegenerative diseases including Parkinson's disease. However, little is known about the mechanisms underlying the neuroprotective activity of H2S in vivo. Here, we evaluated the effect of glibenclamide, an ATP-sensitive potassium channel blocker, on the neuroprotective activity of H2S in the 6-hydroxydopamine (6-OHDA) animal model of Parkinson's disease. Read More

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June 2018
4 Reads

Effects of the antidepressants desipramine and fluvoxamine on latency to immobility and duration of immobility in the forced swim test in adult male C57BL/6J mice.

Behav Pharmacol 2017 Dec 1. Epub 2017 Dec 1.

Pharmacology.

The forced swim test in rodents allows rapid detection of substances with antidepressant-like activity, evidenced as a decreased duration of immobility that is produced by the majority of clinically used antidepressants. Antidepressants also increase the latency to immobility, and this additional measure reportedly can increase the sensitivity of the forced swim test in mice. Extending these findings, the present study examined the effects of desipramine and fluvoxamine in a forced swim test in C57BL/6J mice, a strain commonly used as background for genetic modifications, analyzing results with a method (i. Read More

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December 2017
3 Reads

Changes in gut microbiota during development of compulsive checking and locomotor sensitization induced by chronic treatment with the dopamine agonist quinpirole.

Behav Pharmacol 2018 Apr;29(2 and 3 - Special Issue):211-224

Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada.

Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined whether changes in gut microbiota play a role in these behavioral phenomena, by monitoring the development of compulsive checking and locomotor sensitization at the same time as measuring the response of gut microbiota to chronic quinpirole injections. Read More

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April 2018
6 Reads

Levosimendan enhances memory through antioxidant effect in rat model: behavioral and molecular study.

Behav Pharmacol 2018 Jun;29(4):344-350

Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Impairment of learning and memory has been associated with accumulation of reactive oxygen species in the body. It has also been found that antioxidants enhance learning and memory. Levosimendan is a cardiac inotropic and vasodilator agent that has pleotropic effects including antioxidant, anti-inflammatory, and smooth muscle vasodilatory actions. Read More

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June 2018
5 Reads

The role of N-methyl-D-aspartate receptors and metabotropic glutamate receptor 5 in the prepulse inhibition paradigms for studying schizophrenia: pharmacology, neurodevelopment, and genetics.

Behav Pharmacol 2018 Feb;29(1):13-27

School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University.

Treatments for the positive and negative symptoms of schizophrenia have been explored for decades, but no completely successful therapy has been found as yet. Metabotropic glutamate receptor 5 (mGluR5), which potentiates N-methyl-D-aspartate receptors in brain regions implicated in schizophrenia, has become a novel drug target in the treatment of schizophrenia, especially for the mGluR5-positive allosteric modulators. Individuals with schizophrenia show deficits in prepulse inhibition (PPI), which is an operational measurement of sensorimotor gating. Read More

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February 2018
8 Reads

Parvalbumin-containing GABA cells and schizophrenia: experimental model based on targeted gene delivery through adeno-associated viruses.

Behav Pharmacol 2017 Dec;28(8):630-641

aInstitute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland bLaboratory of Behavioural Neuroscience, National Institute on Aging, Biomedical Research Centre, National Institutes of Health, Baltimore, Maryland, USA cInstitute of Physiology, Christian Albrechts University Kiel, Kiel, Germany.

Understanding the contribution of transmitter systems in behavioural pharmacology has a long tradition. Multiple techniques such as transmitter-specific lesions, and also localized administration of pharmacological toxins including agonists and antagonists of selected receptors have been applied. More recently, modern genetic tools have permitted cell-type selective interferences, for example by expression of light-sensitive channels followed by optogenetic stimulation in behaviourally meaningful settings or by engineered channels termed DREADDS that respond to peripherally administered drugs. Read More

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December 2017
2 Reads