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    2165 results match your criteria Behavioural Pharmacology[Journal]

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    Microinjection of the mGluR2/3 agonist, LY379268, into the nucleus accumbens attenuates extinction latencies and the reinstatement of morphine-induced conditioned place preference in rats.
    Behav Pharmacol 2018 Feb 16. Epub 2018 Feb 16.
    Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences.
    Previous studies indicate that metabotropic glutamate receptor type 2/3 (mGluR2/3) has a key role in the rewarding properties of morphine-induced conditioning place preference (CPP). Group II mGluR2/3 agonists are offered as a drug addiction treatment. The nucleus accumbens (NAc), which is one of the important areas involved in the reward circuitry, also expresses these receptors. Read More

    Medication overuse headache following repeated morphine, but not [INCREMENT]9-tetrahydrocannabinol administration in the female rat.
    Behav Pharmacol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Integrative Physiology and Neuroscience, Graduate Program in Neuroscience.
    The potential of [INCREMENT]-tetrahydrocannabinol (THC) as a treatment for migraine depends on antinociceptive efficacy with repeated administration. Although morphine has good antinociceptive efficacy, repeated administration causes medication overuse headache (MOH) - a condition in which the intensity/frequency of migraine increases. The present study compared the effect of repeated morphine or THC administration on the magnitude and duration of migraine-like pain induced by a microinjection of allyl isothiocyanate (AITC) onto the dura mater of female rats. Read More

    Strain differences in the susceptibility to the gut-brain axis and neurobehavioural alterations induced by maternal immune activation in mice.
    Behav Pharmacol 2018 Feb 16. Epub 2018 Feb 16.
    APC Microbiome Institute.
    There is a growing realization that the severity of the core symptoms of autism spectrum disorders and schizophrenia is associated with gastrointestinal dysfunction. Nonetheless, the mechanisms underlying such comorbidities remain unknown. Several genetic and environmental factors have been linked to a higher susceptibility to neurodevelopmental abnormalities. Read More

    Effects of the active constituents of Crocus sativus L. crocins and their combination with memantine on recognition memory in rats.
    Behav Pharmacol 2018 Feb 16. Epub 2018 Feb 16.
    Laboratory of Chemistry, Department of Food Science and Human Nutrition, School of Food Biotechnology and Development, Agricultural University of Athens, Athens, Greece.
    Crocus sativus L., is a plant cultivated in many countries of the world. Crocins are among the active constituents of C. Read More

    Disulfiram attenuates morphine or methadone withdrawal syndrome in mice.
    Behav Pharmacol 2018 Feb 16. Epub 2018 Feb 16.
    Departments of Pharmacodynamics.
    Taking opioids is often accompanied by the development of dependence. Unfortunately, treatment of opioid dependence is difficult, particularly because of codependence - for example, on alcohol or other drugs of abuse. In the presented study, we analyzed the potential influence of disulfiram, a drug used to aid the management of alcoholism, on opioid abstinence syndrome, which occurs as a result of opioid withdrawal. Read More

    Corticosterone impairs flexible adjustment of spatial navigation in an associative place-reward learning task.
    Behav Pharmacol 2018 Feb 14. Epub 2018 Feb 14.
    Swammerdam Institute for Life Sciences.
    Cognitive challenges are often accompanied by a discharge of stress hormones, which in turn modulate multiple brain areas. Among these, the medial temporal lobe and the prefrontal cortex are critically involved in high-order cognitive functions such as learning, memory, and decision-making. Previous studies assessing the effects of corticosterone on spatial memory found an increase or a decrease in performance depending on the timing of stress hormone discharge relative to the behavioral task. Read More

    Lack of paclitaxel effects on intracranial self-stimulation in male and female rats: comparison to mechanical sensitivity.
    Behav Pharmacol 2018 Jan 23. Epub 2018 Jan 23.
    Departments of Pharmacology and Toxicology.
    Paclitaxel is a cancer chemotherapy with adverse effects that include peripheral neuropathy, neuropathic pain, and depression of behavior and mood. In rodents, hypersensitive paw-withdrawal reflexes from mechanical stimuli serve as one common measure of paclitaxel-induced pain-related behavior. This study tested the hypothesis that paclitaxel would also depress rates of positively reinforced operant responding as a measure of pain-related behavioral depression. Read More

    Choline acetyltransferase and TrkA expression, as well as the improvement in cognition produced by E2 and P4 in ovariectomized rats, are blocked by ICI 182 780 and RU486.
    Behav Pharmacol 2018 Jan 9. Epub 2018 Jan 9.
    Escuela Superior de Medicina, Instituto Politécnico Nacional.
    Treatment with 17-β estradiol and progesterone improves the performance of ovariectomized rats in an autoshaping learning task, representing cognitive improvement. To test whether this is attributable to genomic mechanisms, the antiestrogen ICI 182 780 or antiprogesterone RU486 was injected into ovariectomized animals primed previously with estrogen or progesterone, respectively. Compared with the vehicle control, each hormone administered alone produced an elevated expression of choline acetyltransferase and TrkA, along with an improvement in performance on the behavioral test. Read More

    Enhanced antinociception with repeated microinjections of apomorphine into the periaqueductal gray of male and female rats.
    Behav Pharmacol 2017 Dec 18. Epub 2017 Dec 18.
    Department of Psychology, Washington State University Vancouver.
    Dopamine neurons in the ventrolateral periaqueductal gray (PAG) have been reported to contribute to antinociception. The objective of this study was to determine how this dopamine-mediated antinociception differs from what is known about morphine-induced antinociception. Microinjection of the dopamine receptor agonist apomorphine into the PAG produced a dose-dependent increase in hot plate latency and a decrease in open field activity that was greater in male than in female rats. Read More

    Additive and subadditive antiallodynic interactions between μ-opioid agonists and N-methyl D-aspartate antagonists in male rhesus monkeys.
    Behav Pharmacol 2018 Feb;29(1):41-52
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
    μ-Opioid agonists are clinically effective analgesics, but also produce undesirable effects such as sedation and abuse potential that limit their clinical utility. Glutamatergic systems also modulate nociception and N-methyl D-aspartate (NMDA) receptor antagonists have been proposed as one useful adjunct to enhance the therapeutic effects and/or attenuate the undesirable effects of μ-opioid agonists. Whether NMDA antagonists enhance the antiallodynic effects of μ-agonists in preclinical models of thermal hypersensitivity (i. Read More

    Involvement of adenosine triphosphate-sensitive potassium channels in the neuroprotective activity of hydrogen sulfide in the 6-hydroxydopamine-induced animal model of Parkinson's disease.
    Behav Pharmacol 2017 Dec 12. Epub 2017 Dec 12.
    Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran.
    Studies have shown that hydrogen sulfide (H2S) exerts a neuroprotective effect and may have a therapeutic value for treating neurodegenerative diseases including Parkinson's disease. However, little is known about the mechanisms underlying the neuroprotective activity of H2S in vivo. Here, we evaluated the effect of glibenclamide, an ATP-sensitive potassium channel blocker, on the neuroprotective activity of H2S in the 6-hydroxydopamine (6-OHDA) animal model of Parkinson's disease. Read More

    Effects of the antidepressants desipramine and fluvoxamine on latency to immobility and duration of immobility in the forced swim test in adult male C57BL/6J mice.
    Behav Pharmacol 2017 Dec 1. Epub 2017 Dec 1.
    The forced swim test in rodents allows rapid detection of substances with antidepressant-like activity, evidenced as a decreased duration of immobility that is produced by the majority of clinically used antidepressants. Antidepressants also increase the latency to immobility, and this additional measure reportedly can increase the sensitivity of the forced swim test in mice. Extending these findings, the present study examined the effects of desipramine and fluvoxamine in a forced swim test in C57BL/6J mice, a strain commonly used as background for genetic modifications, analyzing results with a method (i. Read More

    Changes in gut microbiota during development of compulsive checking and locomotor sensitization induced by chronic treatment with the dopamine agonist quinpirole.
    Behav Pharmacol 2017 Jan 16. Epub 2017 Jan 16.
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada.
    Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined whether changes in gut microbiota play a role in these behavioral phenomena, by monitoring the development of compulsive checking and locomotor sensitization at the same time as measuring the response of gut microbiota to chronic quinpirole injections. Read More

    Levosimendan enhances memory through antioxidant effect in rat model: behavioral and molecular study.
    Behav Pharmacol 2017 Nov 21. Epub 2017 Nov 21.
    Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
    Impairment of learning and memory has been associated with accumulation of reactive oxygen species in the body. It has also been found that antioxidants enhance learning and memory. Levosimendan is a cardiac inotropic and vasodilator agent that has pleotropic effects including antioxidant, anti-inflammatory, and smooth muscle vasodilatory actions. Read More

    The role of N-methyl-D-aspartate receptors and metabotropic glutamate receptor 5 in the prepulse inhibition paradigms for studying schizophrenia: pharmacology, neurodevelopment, and genetics.
    Behav Pharmacol 2018 Feb;29(1):13-27
    School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University.
    Treatments for the positive and negative symptoms of schizophrenia have been explored for decades, but no completely successful therapy has been found as yet. Metabotropic glutamate receptor 5 (mGluR5), which potentiates N-methyl-D-aspartate receptors in brain regions implicated in schizophrenia, has become a novel drug target in the treatment of schizophrenia, especially for the mGluR5-positive allosteric modulators. Individuals with schizophrenia show deficits in prepulse inhibition (PPI), which is an operational measurement of sensorimotor gating. Read More

    Parvalbumin-containing GABA cells and schizophrenia: experimental model based on targeted gene delivery through adeno-associated viruses.
    Behav Pharmacol 2017 Dec;28(8):630-641
    aInstitute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland bLaboratory of Behavioural Neuroscience, National Institute on Aging, Biomedical Research Centre, National Institutes of Health, Baltimore, Maryland, USA cInstitute of Physiology, Christian Albrechts University Kiel, Kiel, Germany.
    Understanding the contribution of transmitter systems in behavioural pharmacology has a long tradition. Multiple techniques such as transmitter-specific lesions, and also localized administration of pharmacological toxins including agonists and antagonists of selected receptors have been applied. More recently, modern genetic tools have permitted cell-type selective interferences, for example by expression of light-sensitive channels followed by optogenetic stimulation in behaviourally meaningful settings or by engineered channels termed DREADDS that respond to peripherally administered drugs. Read More

    Differential effects of dopaminergic drugs on spontaneous motor activity in the common marmoset following pretreatment with a bilateral brain infusion of 6-hydroxydopamine.
    Behav Pharmacol 2017 Dec;28(8):670-680
    Central Institute for Experimental Animals, Kawasaki, Japan.
    The differential effects of dopaminergic drugs with different pharmacological profiles were investigated with respect to spontaneous motor activity in the common marmoset following pretreatment with a bilateral brain infusion of 6-hydroxydopamine (6-OHDA). Three marmosets received infusions of 6-OHDA (either 30 or 40 μg/side) into the bilateral dopamine-rich area running from the substantia nigra to the striatum. The motor activity of the 6-OHDA marmosets was compared with that of three intact marmosets. Read More

    Considerations for the use of virally delivered genetic tools for in-vivo circuit analysis and behavior in mutant mice: a practical guide to optogenetics.
    Behav Pharmacol 2017 Dec;28(8):598-609
    aDepartment of Behavioural Neurobiology, Institute of Experimental Medicine bJános Szentágothai School of Neurosciences, Semmelweis University, Budapest cCentre for Neuroscience, Szentágothai Research Centre, Institute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
    Optogenetics was the method of the year in 2010 according to Nature Neuroscience. Since then, this method has become widespread, the use of virally delivered genetic tools has extended to other fields such as pharmacogenetics, and optogenetic techniques have become frequently applied in genetically manipulated animals for in-vivo circuit analysis and behavioral studies. However, several issues should be taken into consideration when planning such experiments. Read More

    Simultaneous monitoring of electroencephalographic characteristics in animals subjected to behavioral tests: a preclinical investigation.
    Behav Pharmacol 2017 Dec;28(8):661-669
    Discovery Research, Suven Life Sciences Ltd, Hyderabad, India.
    Drug-induced changes in electroencephalographic (EEG) characteristics in animals may be used to predict central activity of drugs in humans. Previous studies have established that drugs affect EEG characteristics in humans and rodents in a similar manner. However, there has been little work to establish correlations between drug effects on behavioral and EEG characteristics in rats. Read More

    Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice.
    Behav Pharmacol 2017 Oct 25. Epub 2017 Oct 25.
    aDepartment of Psychopharmacology, Federal State Budgetary Institution 'Research Zakusov Institute of Pharmacology' bDepartment of Pharmacology of Medicine Faculty, Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Sechenov University, Moscow, Russian Federation.
    The antidepressant-like effect of fluoxetine (20 mg/kg i.p.) has been assessed using the forced swimming test (FST) in IRC (CD-1) mice exposed or not to a pretest session of different duration (5 or 20 min). Read More

    Use of fast-scan cyclic voltammetry to assess phasic dopamine release in rat models of early postpartum maternal behavior and neglect.
    Behav Pharmacol 2017 Dec;28(8):648-660
    aBowles Center for Alcohol Studies bDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
    Maternal behavior (MB) is a complex response to infant cues, orchestrated by postpartum neurophysiology. Although mesolimbic dopamine contributes toward MB, little is known about real-time dopamine fluctuations during the postpartum period. Thus, we used fast-scan cyclic voltammetry to measure individual dopamine transients in the nucleus accumbens of early postpartum rats and compared them with dopamine transients in virgins and in postpartum females exposed to cocaine during pregnancy, which is known to disrupt MB. Read More

    Touchscreen technology in the study of cognition-related behavior.
    Behav Pharmacol 2017 Dec;28(8):623-629
    Behavioral Biology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA.
    There is a growing need for new translational animal models designed to capture complex behavioral phenotypes implicated in addiction and other neuropsychiatric conditions. For example, a complete understanding of the effects of commonly abused drugs, as well as candidate medications, requires assessments of their effects on learning, memory, attention, and other cognition-related behavior. Modern touch-sensitive technology provides an extremely flexible means to expose an experimental subject to a variety of complex behavioral tasks designed to assay dimensions of cognitive function before, during, and after drug administration. Read More

    Effect of varenicline on behavioral deficits in a rat model of Parkinson's disease induced by unilateral 6-hydroxydopamine lesion of substantia nigra.
    Behav Pharmacol 2017 Oct 23. Epub 2017 Oct 23.
    aDepartment of Medical Pharmacology, Faculty of Medicine, Pamukkale University, Denizli, Turkey bDepartment of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
    Nicotinic acetylcholine receptors (nAChRs) are implicated in the pathogenesis of Parkinson's disease (PD). Varenicline tartrate is a partial agonist at α4β2 and full agonist at α7 neuronal nAChR subunits. A unilateral lesion of the substantia nigra (SN) has been used as a reliable model of PD. Read More

    The effect of nicotine pre-exposure on demand for cocaine and sucrose in male rats.
    Behav Pharmacol 2017 Oct 23. Epub 2017 Oct 23.
    Department of Psychology, American University, Washington, District of Columbia, USA.
    The aim of the present study was to determine how nicotine pre-exposure affects the elasticity of demand for intravenous cocaine and for sucrose pellets in adult male rats. In Experiment 1, demand for cocaine was assessed in rats that had nicotine in their drinking water. Nicotine pre-exposure significantly decreased rats' willingness to defend cocaine consumption as the price (measured as the number of responses per cocaine infusion) increased compared with a control group with no nicotine pre-exposure. Read More

    Inhibiting social support from massage-like stroking increases morphine dependence.
    Behav Pharmacol 2017 Dec;28(8):642-647
    Department of Psychology, Texas A&M University Texas A&M Institute for Neuroscience (TAMIN), College Station, Texas, USA.
    Our previous studies showed that altering solely the drug experience of the cage mates with which rodents are housed affects the development of morphine dependence. In this study, we used designer receptors exclusively activated by designer drugs to artificially increase or decrease the activity of peripheral dorsal root ganglia sensory neurons expressing the G-protein-coupled receptor MRGPRB4. This is because sensory MRGPRB4-expressing neurons were shown to specifically detect the sensation of massage-like stroking resulting from social grooming, which is an important affiliative social behavior in the rodent. Read More

    Biphasic effects of selective serotonin reuptake inhibitors on anxiety: rapid reversal of escitalopram's anxiogenic effects in the novelty-induced hypophagia test in mice?
    Behav Pharmacol 2017 Oct 13. Epub 2017 Oct 13.
    Departments of aPsychiatry bPharmacology cCellular & Integrative Physiology, University of Texas Health Science Center, San Antonio, Texas, USA.
    In humans, chronic treatment with selective serotonin reuptake inhibitors (SSRIs) decreases anxiety, unlike acute treatment, which can increase anxiety. Although this biphasic pattern is observed clinically, preclinical demonstrations are rare. In an animal model of antidepressant-induced anxiolytic effects, the novelty-induced hypophagia (NIH) test, a single administration of the SSRI citalopram reportedly elicited anxiogenic-like effects, whereas three administrations over 24 h were sufficient to produce anxiolytic-like effects. Read More

    The antidepressant-like effects of sinomenine in mice: a behavioral and neurobiological characterization.
    Behav Pharmacol 2017 Oct 13. Epub 2017 Oct 13.
    aDepartment of Pharmacy, Taizhou People's Hospital, The Fifth Affiliated Hospital of Medical School of Nantong University bYangtze River Pharmaceutical Group, Taizhou cDepartment of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu Province, China.
    Sinomenine is a bioactive alkaloid extracted from Sinomenium acutum. Here, we investigated the antidepressant effects of sinomenine in mice. The antidepressant actions of sinomenine were first examined in the forced-swim test and the tail-suspension test, and then assessed in the chronic social defeat stress (CSDS) model of depression. Read More

    Attenuation of compulsive-like behavior by fluvoxamine in a non-induced mouse model of obsessive-compulsive disorder.
    Behav Pharmacol 2017 Oct 13. Epub 2017 Oct 13.
    Departments of aChemistry & Biochemistry bBiology & Wildlife cIDeA Network of Biomedical Research Excellence (INBRE), University of Alaska Fairbanks, Fairbanks, Alaska, USA.
    The current study evaluated the role of strain and compulsive trait differences in response to fluvoxamine, a common obsessive-compulsive disorder (OCD) drug, in two different mouse strains (BIG1 and BIG2) with a spontaneous compulsive-like phenotype. For compulsive-like nest-building behavior, dose-dependent attenuation of nesting by fluvoxamine was observed for the BIG1 compulsive-like strain during the first hour after administration. No significant differences were found for the BIG2 strain during the first hour, although a dose-dependent trend similar to that in the BIG1 strain was observed. Read More

    Dopaminergic mechanisms in periaqueductal gray-mediated antinociception.
    Behav Pharmacol 2017 Oct 13. Epub 2017 Oct 13.
    Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Brazil.
    As important as perceiving pain is the ability to modulate this perception in some contextual salient situations. The periaqueductal gray (PAG) is perhaps the most important site of endogenous pain modulation; however, little is known about dopaminergic mechanisms underlying PAG-mediated antinociception. In this study, we used a pharmacological approach to evaluate this subject. Read More

    Decreases in smoking during treatment for methamphetamine-use disorders: preliminary evidence.
    Behav Pharmacol 2017 Oct 13. Epub 2017 Oct 13.
    aWashington State University bDepartment of Medical Education and Clinical Sciences, Elson S. Floyd College of Medicine cPrograms of Excellence in Addictions Research dTranslational Addictions Research Center eInitiative for Research and Education to Advance Community Health fProvidence Medical Research Center, Providence Health Care, Spokane, Washington gDepartment of Health Policy and Research, Weill Cornell Medical College, New York City, New York, USA.
    Despite high rates of smoking (70-90%) and the severely negative impact of smoking on physical and mental health, only 12% of individuals receiving stimulant-use disorder treatment also receive smoking-cessation treatment. The aim of this investigation was to examine the effect of a contingency management (CM) intervention targeting methamphetamine (MA) use on cigarette smoking. Sixty-one adults with MA-use disorders who were smokers were assigned to CM or standard psychosocial treatment. Read More

    Effects of morphine/CP55940 mixtures on an impulsive choice task in rhesus monkeys.
    Behav Pharmacol 2018 Feb;29(1):60-70
    Departments of Pharmacology.
    µ-Opioid receptor agonists are commonly used to treat pain despite their adverse effects. In preclinical studies, cannabinoid receptor agonists increase the potency of opioids for producing antinociceptive but not reinforcing effects. It is unknown whether other adverse effects of these drugs, such as impairment of complex behavior, are enhanced by their co-administration. Read More

    The impact of stress on social behavior in adult zebrafish (Danio rerio).
    Behav Pharmacol 2018 Feb;29(1):53-59
    Department of Applied Behavioral Science, University of Kansas, Lawrence, Kansas, USA.
    Stress has adverse effects on social behavior that is mediated by dopamine circuits in the midbrain. The purpose of this research is to examine the effect of chronic stress and dopamine signals on social behavior in zebrafish (Danio rerio). Chronic stress was induced chemically with low dosage of ethanol (0. Read More

    Antinociceptive effects of JWH015 in female and male rats.
    Behav Pharmacol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Psychology, Washington State University, Pullman, Washington, USA.
    Despite greater chronic pain prevalence in females compared with males, and the analgesic potential of cannabinoid receptor type 2 (CB2) agonists, CB2 agonists have rarely been tested in females. The aim of the present study was to compare the antinociceptive effects of a CB2-preferring agonist, (2-methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone (JWH015), in female and male rats against acute pain and persistent inflammatory pain. JWH015 (5-20 mg/kg, intraperitoneally) produced dose-dependent and time-dependent increases in latency to respond on the tail withdrawal and paw pressure tests that did not differ statistically between the sexes. Read More

    Relationship of low doses of alcohol voluntarily consumed during adolescence and early adulthood with subsequent behavioral flexibility.
    Behav Pharmacol 2017 Oct;28(7):531-544
    Department of Psychological Sciences, Kansas State University, Manhattan, Kansas, USA.
    Previous alcohol use is associated with impaired decision-making and impulsivity in humans, but the relationship between alcohol use and decision-making/impulsivity is unclear. In two experiments, we determined whether chronic intermittent access to alcohol during adolescence and early adulthood would alter or be correlated with performance in a go/no-go reversal task, a devaluation task, or operant extinction. Rats received 6 weeks of chronic intermittent access to 20% alcohol or water from postnatal day 26 to 66 and then behavioral testing was initiated 1. Read More

    Neuroprotective effects of coenzyme Q10 on paraquat-induced Parkinson's disease in experimental animals.
    Behav Pharmacol 2018 Feb;29(1):79-86
    Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group), Pharmaceutical and Drug Industries Research Division, National Research Centre, Giza, Egypt.
    Parkinson's disease (PD) affects ∼1-2% of the elderly population. Development of a neuroprotective therapy that may be initiated early in the course of the disease to retard/prevent disease progression is highly desirable. This study aimed to investigate prophylactic treatment with coenzyme Q10 (CoQ10) before paraquat (PQ) exposure, a herbicide known to increase the risk for PD, to attain neuroprotection. Read More

    Dexamethasone impairs encoding and expression of aversive conditioning promoted by pentylenetetrazole.
    Behav Pharmacol 2017 Aug 31. Epub 2017 Aug 31.
    aDepartment of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis bAcademic Unity of Health Sciences, University of Extremo Sul Catarinense, Criciúma, Brazil.
    Behavioral and neuroendocrine responses following threatening situations promote the release of corticosterone, which is known to modulate trauma-related learning and memory process. However, it remains unknown whether the aversive learning generated by interoceptive fear conditioning is affected by glucocorticoid modulation. Therefore, the present study aimed to investigate the role of dexamethasone suppression in encoding and expression of pentylenetetrazole-induced olfactory fear conditioning (OFC) and in contextual second-order conditioning promoted by the conditioned odor. Read More

    Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats.
    Behav Pharmacol 2018 Feb;29(1):87-97
    Psychology Department, Creighton University, Omaha, Nebraska.
    Methamphetamine is a potent psychostimulant with high abuse rates. Currently, there is no Food and Drug Administration-approved pharmacotherapy for methamphetamine addiction. Ideally, a pharmacotherapy should selectively decrease methamphetamine self-administration without affecting responding for other reinforcers. Read More

    Histamine H3 receptor antagonists ameliorate attention deficit/hyperactivity disorder-like behavioral changes caused by neonatal habenula lesion.
    Behav Pharmacol 2018 Feb;29(1):71-78
    Department of Food Science and Nutrition, Daegu Catholic University, Gyeongsan, Gyeongbuk, South Korea.
    A partial agonist and a full antagonist of the histamine H3 receptor have been suggested to have therapeutic effects on cognitive deficits in psychiatric disorders. We have previously shown that neonatal habenula lesion (NHL) induces behavioral deficits that resemble the symptoms of attention deficit/hyperactivity disorder (ADHD). In this study, we examined the effects of three H3 antagonists on ADHD-like behavioral changes caused by NHL in rats. Read More

    Clinical potential of oxytocin in autism spectrum disorder: current issues and future perspectives.
    Behav Pharmacol 2018 Feb;29(1):1-12
    Department of Neuropsychiatry, School of Medicine, The University of Tokyo, Tokyo.
    The effects of oxytocin on social cognition and behavior have recently attracted considerable attention. In particular, oxytocin has been proposed as a novel therapeutic for psychiatric disorders with social deficits such as autism spectrum disorders. This review provides a brief overview of behavioral and neural responses to oxytocin manipulations in humans and animal models. Read More

    A serotonergic deficit in the dorsal periaqueductal gray matter may underpin enhanced panic-like behavior in diabetic rats.
    Behav Pharmacol 2017 Oct;28(7):558-564
    aDepartment of Pharmacology, Federal University of Paraná, Curitiba bDepartment of Pharmacology and Therapeutics, State University of Maringá, Maringá cDepartment of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
    It is known that diabetic (DBT) animals present dysregulation on the serotonergic system in several brain areas associated with anxiety-like responses. The aim of this study was to investigate the involvement of 5-HT1A receptors on dorsal periaqueductal gray (dPAG) in the behavioral response related to panic disorder in type-1 DBT animals. For this, the escape response by electric stimulation (ES) of dPAG in DBT and normoglycemic (NGL) animals was assessed. Read More

    Effects of systemic glutamatergic manipulations on conditioned eyeblink responses and hyperarousal in a rabbit model of post-traumatic stress disorder.
    Behav Pharmacol 2017 Oct;28(7):565-577
    aBlanchette Rockefeller Neurosciences Institute bDepartment of Physiology and Pharmacology, Health Sciences Center, West Virginia University, Morgantown, West Virginia, USA.
    Glutamatergic dysfunction is implicated in many neuropsychiatric conditions, including post-traumatic stress disorder (PTSD). Glutamate antagonists have shown some utility in treating PTSD symptoms, whereas glutamate agonists may facilitate cognitive behavioral therapy outcomes. We have developed an animal model of PTSD, based on conditioning of the rabbit's eyeblink response, that addresses two key features: conditioned responses (CRs) to cues associated with an aversive event and a form of conditioned hyperarousal referred to as conditioning-specific reflex modification (CRM). Read More

    Mood-stabilizing effects of rapamycin and its analog temsirolimus: relevance to autophagy.
    Behav Pharmacol 2017 Aug 2. Epub 2017 Aug 2.
    aSchool of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel Aviv, Israel bDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel cDepartment of Psychology, Saint Francis University, Loretto, Pennsylvania dDepartment of Pharmacy Practice and Pharmaceutical Sciences, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA.
    Accumulated data support a relationship between mood disorders and cellular plasticity and resilience, some suggesting relevance to autophagy. Our previous data show that pharmacological enhancement of autophagy results in antidepressant-like effects in mice. The current study was designed to further examine the effects of autophagy enhancement on mood by testing the effects of subchronic treatment with the mammalian target of rapamycin inhibitors and autophagy enhancers rapamycin and temsirolimus in a model for mania and in a model for antidepressant action, respectively. Read More

    Insights into the potential antidepressant mechanisms of cilostazol in chronically restraint rats: impact on the Nrf2 pathway.
    Behav Pharmacol 2018 Feb;29(1):28-40
    Department of Pharmacology, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
    Ample evidence has pointed to a close link between oxidative stress, mitochondrial dysfunction, and depression. Nuclear factor-erythroid 2-related factor-2 (Nrf2) is a master regulator of cellular redox homeostasis and affects mitochondrial function. Nrf2 holds promise for depression prevention and treatment. Read More

    Intramuscularly injected neurotropin reduced muscular mechanical hyperalgesia induced by repeated cold stress in rats.
    Behav Pharmacol 2017 Jul 31. Epub 2017 Jul 31.
    aDepartment of Physical Therapy, Faculty of Health Sciences, Mejiro University, Saitama bDepartment of Physical Therapy, College of Life and Health Sciences, Chubu University, Kasugai, Japan.
    An extract of rabbit skin inflamed by inoculation with the vaccinia virus, neurotropin [by intravenous, oral, and intramuscular (i.m.) administration], has been used in China and Japan for the treatment of chronic pain. Read More

    Trace amine-associated receptor 1 agonists RO5263397 and RO5166017 attenuate quinpirole-induced yawning but not hypothermia in rats.
    Behav Pharmacol 2017 Oct;28(7):590-593
    aDepartment of Pharmacology and Toxicology, University at Buffalo, Buffalo, New York bResearch Triangle Institute, Research Triangle Park, North Carolina, USA.
    Increasing evidence suggests that trace amine-associated receptor 1 (TAAR1) is an important modulator of the dopaminergic system. Existing molecular evidence indicates that TAAR1 regulates dopamine levels through interactions with dopamine transporters and D2 receptors. However, investigations to date have not been exhaustive and other pathways may be involved. Read More

    Effects of ceftriaxone on conditioned nicotine reward in rats.
    Behav Pharmacol 2017 Sep;28(6):485-488
    Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
    Nicotine is the addictive compound in tobacco products which exerts psychosomatic effects that contribute to abuse and to low rates of abstinence in treatment-seeking smokers. At present, the most successful smoking cessation aide helps one in four individuals quit smoking at 1 year postcessation. New adjunctive therapies are needed to improve status of smoking-related public health crises, and β-lactam antibiotics are one class of potential therapies as they favorably augment extrasynaptic glutamate clearance. Read More

    Effects of D1 and D2 receptor antagonists on the discriminative stimulus effects of methylendioxypyrovalerone and mephedrone in male Sprague-Dawley rats trained to discriminate D-amphetamine.
    Behav Pharmacol 2017 Oct;28(7):586-589
    Department of Psychology, Western Michigan University, Kalamazoo, Michigan, USA.
    Psychopharmacology research has amassed substantial evidence for similarities between synthetic cathinones and other commonly abused psychostimulants. Few studies have utilized drug discrimination methods to investigate synthetic cathinones, and the precise neurochemical substrates underlying their interoceptive effects have not been examined. The present study assessed the involvement of D1 and D2 dopaminergic receptors in the stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) and mephedrone (MEPH) in rats trained to discriminate D-amphetamine. Read More

    Agonist E-6837 and antagonist SB-271046 of 5-HT6 receptors both reverse the depressive-like effect induced in mice by subchronic ketamine administration.
    Behav Pharmacol 2017 Oct;28(7):582-585
    aEscuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City bFaculty of Human Medicine, Autonomous University of Chiapas, Tuxtla Gutiérrez, Chiapas, Mexico.
    Major depression is one of the most common affective disorders caused by schizophrenia. The administration of N-methyl-D-aspartate receptor antagonists, such as ketamine, can reproduce the negative and affective symptoms of this disorder in animals. Preclinical studies have shown that 5-HT6 receptor (5-HT6R) agonists and antagonists have a considerable antipsychotic response. Read More

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