2,261 results match your criteria Behavioural Pharmacology[Journal]


The blockade of corticotropin-releasing factor 1 receptor attenuates anxiety-related symptoms and hypothalamus-pituitary-adrenal axis reactivity in mice with mild traumatic brain injury.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):220-228

Drug Applied Research Center.

Recent studies have shown that mild traumatic brain injury (mTBI) is associated with higher risk for anxiety-related disorders. Dysregulation in the hypothalamus-pituitary-adrenal (HPA) axis following mTBI has been proposed to be involved in the development of neurobehavioral abnormalities; however, the underlying mechanisms are largely unknown. The aim of this study was to determine whether the corticotropin-releasing-factor-1 (CRF-1) receptor is involved in the regulation of anxiety-related symptoms in a mouse model of mTBI. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000450DOI Listing
April 2019
1 Read

Quercetin mitigates anxiety-like behavior and normalizes hypothalamus-pituitary-adrenal axis function in a mouse model of mild traumatic brain injury.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):282-289

Drug Applied Research Center.

Mild traumatic brain injury (mTBI) is a major public health risk for developing anxiety-related disorders and hypothalamus-pituitary-adrenal (HPA) axis dysregulation in humans. Extensive research has shown that dietary intake or supplementation of the natural flavonoid quercetin might be useful for treating anxiety-related symptoms. The objectives of this study were to determine whether quercetin treatment can attenuate anxiogenic-like behaviors and normalize HPA axis function in mice with mTBI. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000480DOI Listing
April 2019
1 Read

The behavioural pharmacology of stress-related disorders.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):101-103

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http://dx.doi.org/10.1097/FBP.0000000000000481DOI Listing

The 'Yin' and the 'Yang' of the kynurenine pathway: excitotoxicity and neuroprotection imbalance in stress-induced disorders.

Authors:
Pascal Barone

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):163-186

UMR 1253, iBrain, University of Tours, Inserm, Tours, France.

The amino-acid tryptophan (TRY) is converted into kynurenine (KYN) and subsequent metabolites by the tryptophan/catabolites (TRY/CAT) pathway (kynurenine pathway). 'Excito-toxic' and 'neuro-protective' metabolites are produced, which modulate the glutamatergic neurotransmission. The TRY/CAT pathway is activated by hypothalamic-pituitary-adrenal endocrine induction during stress by corticoids hormones, and the excitotoxic branch of the TRY/CAT pathway is activated by proinflammatory cytokines. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000477DOI Listing
April 2019
1 Read

Stress and the gut microbiota-brain axis.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):187-200

Department of Nursing Science, Physiotherapy and Medicine, University of Almería, Almería, Spain.

Stress is a nonspecific response of the body to any demand imposed upon it, disrupting the body homoeostasis and manifested with symptoms such as anxiety, depression or even headache. These responses are quite frequent in the present competitive world. The aim of this review is to explore the effect of stress on gut microbiota. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000478DOI Listing
April 2019
2 Reads

Edaravone prevents memory impairment in an animal model of post-traumatic distress.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):201-207

Department of Physiology and Biochemistry.

Post-traumatic stress disorder (PTSD) is a mental health problem that develops in a proportion of individuals after experiencing a potential life-threatening traumatic stress event. Edaravone is a free radical scavenger, with a neuroprotective effect against cognitive impairment in several animal models. In the present study, the protective effect of edaravone on PTSD-induced memory impairment was investigated. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000479DOI Listing
April 2019
1 Read

Alterations of acoustic features of 50 kHz vocalizations by nicotine and phencyclidine in rats.

Behav Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.

Ultrasonic vocalizations are widely used to examine affective states in rats, yet relatively few studies explore the acoustic features of vocalizations, especially in relation to drug exposure, and no studies have explored alterations in acoustic features over time. The goal of this study was to examine nicotine- and phencyclidine-induced alterations of bandwidth, duration, and frequency of 50 kHz vocalizations. The minimum and maximum frequency, bandwidth, and duration of calls were examined after 7 days of daily subcutaneous administration of phencyclidine (2. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000463DOI Listing
February 2019

A further assessment of a role for Toll-like receptor 4 in the reinforcing and reinstating effects of opioids.

Behav Pharmacol 2019 Feb 7. Epub 2019 Feb 7.

Psychobiology Section, Department of Health and Human Services, Molecular Neuropsychiatry Research Branch, Intramural Research Program.

The Toll-like receptor 4 (TLR4) antagonists, (+)-naloxone and (+)-naltrexone, have been reported to decrease self-administration of opioids in rats and to reduce other preclinical indicators of abuse potential. However, under the self-administration conditions studied, the effects of TLR4 antagonists were not reinforcer selective, questioning the involvement of those receptors and their mediated inflammatory response specifically in opioid abuse. The objectives of the current study were to further characterize the reinforcer specificity of TLR4 antagonism in opioid self-administration and to explore its effects in a preclinical model of craving/relapse. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000474DOI Listing
February 2019
4 Reads
2.148 Impact Factor

Animal models of post-traumatic stress disorder and novel treatment targets.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):130-150

The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.

Understanding the neurobiological basis of post-traumatic stress disorder (PTSD) is fundamental to accurately diagnose this neuropathology and offer appropriate treatment options to patients. The lack of pharmacological effects, too often observed with the most currently used drugs, the selective serotonin reuptake inhibitors (SSRIs), makes even more urgent the discovery of new pharmacological approaches. Reliable animal models of PTSD are difficult to establish because of the present limited understanding of the PTSD heterogeneity and of the influence of various environmental factors that trigger the disorder in humans. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000467DOI Listing
April 2019
5 Reads

Animal models of liability to post-traumatic stress disorder: going beyond fear memory.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):122-129

Department of Psychology, 'Sapienza' University of Rome.

In this review, we advocate a dimensional approach on the basis of candidate endophenotypes to the development of animal models of post-traumatic stress disorder (PTSD) capable of including genetic liability factors, variations in symptoms profile and underlying neurobiological mechanisms, and specific comorbidities. Results from the clinical literature pointed to two candidate endophenotypes of PTSD: low sensory gating and high waiting impulsivity. Findings of comparative studies in mice of two inbred strains characterized by different expressions of the two candidate endophenotypes showed different strain-specific neural and behavioral effects of stress experiences. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000475DOI Listing

Role of AMPA receptor stimulation and TrkB signaling in the antidepressant-like effect of ketamine co-administered with a group II mGlu receptor antagonist, LY341495, in the forced swim test in rats.

Behav Pharmacol 2019 Feb 4. Epub 2019 Feb 4.

Department of Neurobiology, Polish Academy of Sciences, Institute of Pharmacology.

Ketamine has been shown to induce a rapid antidepressant effect on patients with depression. In many animal models, both rapid and sustained antidepressant activities were also found in response to an antagonist of group II metabotropic glutamate receptors, LY341495, and its mechanism of action seemed to be similar in many ways to the action of ketamine. It has also been found that LY341495 enhanced the antidepressant-like activity of sub-effective doses of ketamine in rats without inducing adverse effects. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000471DOI Listing
February 2019

The muscarinic agonist pilocarpine modifies cocaine-reinforced and food-reinforced responding in rats: comparison with the cholinesterase inhibitor tacrine.

Behav Pharmacol 2019 Feb 4. Epub 2019 Feb 4.

Substance Abuse Research Laboratory, Kansas City Veterans Affairs Medical Center, Kansas City, Missouri.

Activation of muscarinic receptors in the brain antagonizes the actions of cocaine, blocking both its discriminative stimulus and reinforcing properties. Pilocarpine is a nonselective muscarinic agonist that is used clinically, but has not been well characterized for its actions during cocaine-reinforced behavior. This study evaluated its effects on cocaine-reinforced and food-reinforced behaviors in rats, using the cholinesterase inhibitor tacrine as a comparator. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000472DOI Listing
February 2019

Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice.

Behav Pharmacol 2019 Feb 4. Epub 2019 Feb 4.

Department of Psychological Sciences, Augusta University, Augusta, Georgia, USA.

Pain is a significant public health problem, and assessment of pain-related impairment of behavior is a key clinical indicator and treatment target. Similar to opioids and NSAIDs, dopamine (DA) transporter inhibitors block pain-related depression of intracranial self-stimulation (ICSS) in rats. The primary goal of the present study was to determine if the effects of monoamine uptake inhibitors on pain-related depression of ICSS in rats extend to an assay of pain-related depression of nesting in mice. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000469DOI Listing
February 2019

Early-life stress influences acute and sensitized responses of adult mice to cocaine by interacting with GABAA α2 receptor expression.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):272-281

Laboratory of Behavioural and Clinical Neuroscience, School of Psychology, University of Sussex, Brighton.

Early-life stress (ELS) is known to exert long-term effects on brain function, with resulting deleterious consequences for several aspects of mental health, including the development of addiction to drugs of abuse. One potential mechanism in humans is suggested by findings that ELS interacts with polymorphisms of the GABRA2 gene, encoding α2 subunits of GABAA receptors, to increase the risk for both post-traumatic stress disorder and vulnerability to cocaine addiction. We used a mouse model, in which the amount of material for nest building was reduced during early postnatal life, to study interactions between ELS and expression of α2-containing GABAA receptors in influencing cocaine-related behaviour. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000466DOI Listing
April 2019
2 Reads

Celecoxib potentiates the antianxiety and anticompulsive-like activity of fluoxetine against chronic unpredictable mild stress in experimental animals.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):251-259

Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, India.

Obsessive-compulsive disorder (OCD) is considered a heterogeneous anxiety disorder that includes compulsions. Celecoxib is considered an adjuvant to fluoxetine in the management of OCD in a clinical study. However, the experimental evidence is yet to be established. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000468DOI Listing
April 2019
1 Read
2.148 Impact Factor

Early life exposure to cortisol in zebrafish (Danio rerio): similarities and differences in behaviour and physiology between larvae of the AB and TL strains.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):260-271

Department of Animal Ecology and Physiology, Institute of Water and Wetland Research, Faculty of Science, Radboud University, Nijmegen, The Netherlands.

Maternal stress and early life stress affect development. Zebrafish (Danio rerio) are ideally suited to study this, as embryos develop externally into free-feeding larvae. The objective of this study was therefore to assess the effects of increased levels of cortisol, mimicking thereby maternal stress, on larval physiology and behaviour. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000470DOI Listing

Changes in behavioral and neuronal parameters by alcohol, cigarette, or their combined use in rats.

Behav Pharmacol 2019 Feb 4. Epub 2019 Feb 4.

Department of Pharmacology, Postgraduate Program in Pharmacology and Therapeutics.

Few studies have explored the effects of the combined use of alcohol and cigarette in humans, despite its prevalence. Here we evaluated the effect of isolated and combined use on behaviors and neuronal parameters in rats. Male adult rats were divided into alcohol (AL, 2 g/kg, by oral gavage), cigarette smoke (TB, six cigarettes, by inhalation), combined use (ALTB), or control (CT, water by oral gavage and environmental air) groups, treated twice a day (09. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000476DOI Listing
February 2019
9 Reads

Parental morphine exposure enhances morphine (but not methamphetamine) preference and increases monoamine oxidase-B level in the nucleus accumbens.

Behav Pharmacol 2019 Jan 28. Epub 2019 Jan 28.

Iranian National Center for Addiction Studies.

Opioid addiction is one of the most crucial issues in the world. Opioid abuse by parents makes children more prone to many psychological disorders such as drug addiction. Therefore, this study was carried out to examine the effect of morphine exposure 10 days before gestation on morphine and methamphetamine preference in male offspring. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000465DOI Listing
January 2019
4 Reads

Stress reactivity after traumatic brain injury: implications for comorbid post-traumatic stress disorder.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):115-121

Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Most people have or will experience traumatic stress at some time over the lifespan, but only a subset of traumatized individuals develop post-traumatic stress disorder (PTSD). Clinical research supports high rates of traumatic brain injury (TBI)-PTSD comorbidity and demonstrates TBI as a significant predictor of the development of PTSD. Biological factors impacted following brain injury that may contribute to increased PTSD risk are unknown. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422696PMC
April 2019
14 Reads

Effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 on pain-depressed behavior in rats: comparison with ketorolac and diazepam.

Behav Pharmacol 2019 Jan 10. Epub 2019 Jan 10.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.

This study examined effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 in an assay of pain-related behavioral depression. Adult, male Sprague-Dawley rats responded for electrical brain stimulation in a frequency-rate intracranial self-stimulation (ICSS) procedure. Intraperitoneal injection of 1. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000464DOI Listing
January 2019
1 Read

The predator odor avoidance model of post-traumatic stress disorder in rats.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):105-114

Department of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Individuals with post-traumatic stress disorder avoid trauma-related stimuli and exhibit blunted hypothalamic-pituitary-adrenal axis response at the time of trauma. Our laboratory uses predator odor (i.e. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422743PMC
April 2019
1 Read

Anti-NGF treatment can reduce chronic neuropathic pain by changing peripheral mediators and brain activity in rats.

Behav Pharmacol 2019 02;30(1):79-88

Department of Anatomy, Institute of Biomedical Science-III, University of Sao Paulo, Sao Paulo, Brazil.

Neuropathic pain is driven by abnormal peripheral and central processing, and treatments are insufficiently effective. Antibodies against nerve growth factor (anti-NGF) have been investigated as a potent analgesic treatment for numerous conditions. However, the peripheral and brain effects of anti-NGF in neuropathic pain remain unknown. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000422DOI Listing
February 2019
1 Read

Serotonin 2A receptors are a stress response system: implications for post-traumatic stress disorder.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):151-162

Department of Pharmaceutical Sciences, Mercer University College of Pharmacy, Mercer University Health Sciences Center, Atlanta, Georgia, USA.

Serotonin, one of the first neurotransmitters to be identified, is an evolutionarily old molecule that is highly conserved across the animal kingdom, and widely used throughout the brain. Despite this, ascribing a specific set of functions to brain serotonin and its receptors has been difficult and controversial. The 2A subtype of serotonin receptors (5-HT2A receptor) is the major excitatory serotonin receptor in the brain and has been linked to the effects of drugs that produce profound sensory and cognitive changes. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422730PMC
April 2019
2 Reads

Influence of aversive stimulation on haloperidol-induced catalepsy in rats.

Behav Pharmacol 2019 Apr;30(2 and 3 - Special Issue):229-238

Institute of Neuroscience and Behavior (INeC).

Catalepsy - an immobile state in which individuals fail to change imposed postures - can be induced by haloperidol. In rats, the pattern of haloperidol-induced catalepsy is very similar to that observed in Parkinson's disease (PD). As some PD symptoms seem to depend on the patient's emotional state, and as anxiety disorders are common in PD, it is possible that the central mechanisms regulating emotional and cataleptic states interplay. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000462DOI Listing
April 2019
4 Reads

New procognitive enhancers acting at the histamine H3 and AMPA receptors reverse natural forgetting in mice: comparisons with donepezil and memantine in the object recognition task.

Behav Pharmacol 2018 Nov 26. Epub 2018 Nov 26.

Institute of Cognitive and Integrative Neurosciences, Saint-Hilaire Pessac, France.

This study evaluated the procognitive effects of S 38093 (a new inverse agonist of the histaminergic H3 receptor) and S 47445 (a new α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) in 2-3-month-old Swiss mice as compared with donepezil and memantine, two main reference compounds in the treatment of Alzheimer's disease. The object recognition task allows the study of natural forgetting and is classically used in assessing drug effects on memory. Here, we show that mice exhibit significant object recognition at short (15 min) but not long (24 h) retention intervals separating the familiarization and recognition phases. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000418DOI Listing
November 2018
2 Reads

Further pharmacological comparison of D-methamphetamine and L-methamphetamine in rats: abuse-related behavioral and physiological indices.

Behav Pharmacol 2018 Nov 21. Epub 2018 Nov 21.

Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, New York.

Previous preclinical research suggests that L-methamphetamine (L-MA) has potential therapeutic utility to treat psychostimulant abuse. This study examined potential abuse-related and adverse physiological effects of D-MA and L-MA alone and in combination in rats, as these effects had not been previously characterized. Potential abuse-related effects were examined in locomotor sensitization and conditioned place preference paradigms. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000453DOI Listing
November 2018
2 Reads

Select panicogenic drugs and stimuli induce consistent increases in tail skin flushes and decreases in core body temperature.

Behav Pharmacol 2018 Nov 21. Epub 2018 Nov 21.

Department of Anatomy and Cell Biology.

Panic attacks (PAs) are episodes of intense fear or discomfort that are accompanied by a variety of both psychological and somatic symptoms. Panic induction in preclinical models (e.g. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000440DOI Listing
November 2018
3 Reads

Assessment of executive function using the Tinkertoy test.

Behav Pharmacol 2018 12;29(8):709-715

School of Psychology, University of Ottawa, Ottawa, Ontario, Canada.

The Tinkertoy test (TTT) has often been used to assess executive function. Despite its clinical importance, there are few published normative data for it. Thus, the primary aim of this study was to fill this gap. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000434DOI Listing
December 2018
1 Read

Vigilance demand and the effects of stimulant drugs in a five-choice reaction-time procedure in mice.

Behav Pharmacol 2018 12;29(8):701-708

Psychobiology Section Molecular Neuropsychiatry Branch, National Institute on Drug Abuse - Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA.

Stimulant drugs used for treating attention-deficit hyperactivity disorder (ADHD) increase signal-detection accuracy in five-choice serial reaction-time procedures. These increases may result from drug-induced increases in control exerted by the stimuli that prompt responses, which was assessed in the present study. Mice were trained with food reinforcement to nose poke into one of five holes after its illumination (signal), and effects of methylphenidate, d-amphetamine, and pentobarbital were assessed. Read More

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http://Insights.ovid.com/crossref?an=00008877-201812000-0000
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http://dx.doi.org/10.1097/FBP.0000000000000435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234857PMC
December 2018
7 Reads
2.148 Impact Factor

Differential cross-tolerance to the effects of nicotinic acetylcholine receptor drugs in C57BL/6J mice following chronic varenicline.

Behav Pharmacol 2018 Nov 5. Epub 2018 Nov 5.

Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.

Varenicline is a smoking cessation pharmacotherapy with a presumed mechanism of action of partial efficacy at the α4β2 nicotinic acetylcholine receptor (nAChR); however, the extent to which daily varenicline use leads to changes in nAChR sensitivity is unclear. This study examined the consequences of daily varenicline treatment on disruptions in operant responding (i.e. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000452DOI Listing
November 2018
8 Reads

Monoaminergic modulation of decision-making under risk of punishment in a rat model.

Behav Pharmacol 2018 12;29(8):745-761

Department of Psychiatry.

The ability to decide advantageously among options that vary in both their risks and rewards is critical for survival and well-being. Previous work shows that some forms of risky decision-making are robustly modulated by monoamine signaling, but it is less clear how monoamine signaling modulates decision-making under risk of explicit punishment. The goal of these experiments was to determine how this form of decision-making is modulated by dopamine, serotonin, and norepinephrine signaling, using a task in which rats choose between a small, 'safe' food reward and a large food reward associated with variable risks of punishment. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291248PMC
December 2018
2 Reads

Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.

Behav Pharmacol 2018 Oct 31. Epub 2018 Oct 31.

Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, New York.

Pharmacotherapies for fibromyalgia treatment are lacking. This study examined the antinociceptive and antidepressant-like effects of imidazoline I2 receptor (I2R) agonists in a reserpine-induced model of fibromyalgia in rats. Rats were treated for 3 days with vehicle or reserpine. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000454DOI Listing
October 2018
3 Reads

Sexual behaviour of the female rat during late adolescence: effect of chronic cocaine treatment.

Behav Pharmacol 2018 Oct 30. Epub 2018 Oct 30.

Department of Physiology and Nutrition.

Sexual behaviour is highly motivated and female rats begin to express it during adolescence. The circuitries implicated in the control of motivated behaviours continue to mature during adolescence and seem more sensitive to the effects of psychostimulants such as cocaine. However, a putative differential effect of this drug on the sexual behaviour of females according to age has not yet been studied. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000451DOI Listing
October 2018
1 Read

Functional and molecular changes in the nucleus accumbens of MK-801-sensitized rats.

Behav Pharmacol 2018 Oct 30. Epub 2018 Oct 30.

Queensland Brain Institute, The University of Queensland.

Behavioural sensitization is a putative mechanism in the pathophysiology of drug addiction and neuropsychiatric disorders such as schizophrenia. In rodents, drug-induced behavioural sensitization has been described for several different drug classes. The N-methyl-D-aspartate receptor antagonist MK-801 can inhibit sensitization to other drugs of abuse. Read More

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http://Insights.ovid.com/crossref?an=00008877-900000000-9927
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http://dx.doi.org/10.1097/FBP.0000000000000447DOI Listing
October 2018
18 Reads

Normal extinction and reinstatement of morphine-induced conditioned place preference in the GluA1-KO mouse line.

Behav Pharmacol 2018 Oct 29. Epub 2018 Oct 29.

Department of Pharmacology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Extinction and reinstatement of morphine-induced conditioned place preference were studied in glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-receptor GluA1 subunit-deficient mice (global GluA1-KO mice). In line with previous findings, both acquisition and expression of conditioned place preference to morphine (20 mg/kg, subcutaneously) were fully functional in GluA1 KO mice compared with wild-type littermate controls (GluA1-WT), thus enabling the study of extinction. With a 10-session extinction paradigm, the GluA1 KO mice showed complete extinction similar to that of the GluA1-WT mice. Read More

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http://Insights.ovid.com/crossref?an=00008877-900000000-9927
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http://dx.doi.org/10.1097/FBP.0000000000000449DOI Listing
October 2018
12 Reads

Investigating the influence of 'losses disguised as wins' on decision making and motivation in rats.

Behav Pharmacol 2018 12;29(8):732-744

Departments of Psychology, Djavad Mowafaghian Centre for Brain Health.

Multiline slot machines encourage continued play through 'losses disguised as wins' (LDWs), outcomes in which the money returned is less than that wagered. Individuals with gambling problems may be susceptible to this game feature. The cognitive and neurobiological mechanisms through which LDWs act are unknown. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000455DOI Listing
December 2018
1 Read

Impulsive choice does not predict binge-like eating in rats.

Behav Pharmacol 2018 12;29(8):726-731

Laboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry.

Binge eating disorder is an addiction-like disorder characterized by recurrent, excessive food consumption within discrete periods of time, and it has been linked to increased trait impulsivity. Within impulsivity components, while impulsive action was shown to predict binge-like and addictive-like eating, the role of impulsive choice is instead unknown. The goal of this study was to determine if impulsive choice predicted, or was altered by binge-like eating of a sugary, highly palatable diet. Read More

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http://Insights.ovid.com/crossref?an=00008877-900000000-9927
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http://dx.doi.org/10.1097/FBP.0000000000000446DOI Listing
December 2018
12 Reads

Punishment and reinforcement by opioid receptor agonists in a choice procedure in rats.

Behav Pharmacol 2018 Oct 12. Epub 2018 Oct 12.

Departments of Pharmacology.

Intravenous (i.v.) drug self-administration remains the 'gold standard' for assessing abuse potential of drugs. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461530PMC
October 2018
2 Reads

Attenuation of glutamatergic and nitrergic system contributes to the antidepressant-like effect induced by capsazepine in the forced swimming test.

Behav Pharmacol 2019 02;30(1):59-66

Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

The transient receptor potential vanilloid 1 (TRPV1) can modulate stress-related behaviours, thus representing an interesting target for new antidepressant drugs. TRPV1 can trigger glutamate release and nitric oxide synthesis in the brain, mechanisms also involved in the neurobiology of depression. However, it is not known if these mechanisms are involved in TRPV1-induced behavioural effects. Read More

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http://Insights.ovid.com/crossref?an=00008877-900000000-9927
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http://dx.doi.org/10.1097/FBP.0000000000000416DOI Listing
February 2019
3 Reads

The effect of nicotine and nicotine+monoamine oxidase inhibitor on the value of alcohol.

Behav Pharmacol 2018 Sep 27. Epub 2018 Sep 27.

Department of Psychology, Utah State University, Logan, Utah, USA.

Alcohol is the most commonly abused drug in the USA and many people suffer from alcohol use disorder. Many factors are associated with alcohol use disorder, but the causal role of comorbid nicotine use has not been extensively considered. Nicotine has reward-enhancing properties and may increase the value of alcohol. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000438DOI Listing
September 2018
4 Reads

Olfaction in female Wistar rats is influenced by dopaminergic periglomerular neurons after nigral and bulbar lesions.

Behav Pharmacol 2018 Sep 14. Epub 2018 Sep 14.

Neurophysiology Laboratory, Department of Physiology, Federal University of Paraná, Curitiba, Brazil.

Hyposmia is found in Parkinsonian patients decades before the onset of motor disorders. The same occurs with sleep disorders, especially infuencing rapid eye movement (REM) sleep, which affect a large percentage of people who have Parkinson's disease. These two disturbances presumably are closely related to a dopaminergic dysfunction. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000443DOI Listing
September 2018
11 Reads

Classic animal models of Parkinson's disease: a historical perspective.

Behav Pharmacol 2018 Sep 13. Epub 2018 Sep 13.

Neurodegenerative Disease Group, Montreal Neurological Institute.

The quest to better understand the pathophysiology of Parkinson's disease (PD) and to find new therapies to provide greater relief to affected patients continues. The use of animal models of PD has been invaluable in the process. Here, we review, through a historical lens, some of the contribution of the 6-hydroxydopamine-lesioned rat and of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned nonhuman primate, in refining our understanding of PD and its treatment-related complications. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000441DOI Listing
September 2018
1 Read

Executive (dys)function after stroke: special considerations for behavioral pharmacology.

Behav Pharmacol 2018 10;29(7):638-653

Center for Basic and Translational Stroke Research.

Stroke is a worldwide leading cause of death and long-term disability with concurrent secondary consequences that are largely comprised of mood dysfunction, as well as sensory, motor, and cognitive deficits. This review focuses on the cognitive deficits associated with stroke specific to executive dysfunction (including decision making, working memory, and cognitive flexibility) in humans, nonhuman primates, and additional animal models. Further, we review some of the cellular and molecular underpinnings of the individual components of executive dysfunction and their neuroanatomical substrates after stroke, with an emphasis on the changes that occur during biogenic monoamine neurotransmission. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152929PMC
October 2018
4 Reads

Executive (dys)function after traumatic brain injury: special considerations for behavioral pharmacology.

Behav Pharmacol 2018 10;29(7):617-637

Injury and Recovery Laboratory, Department of Psychology.

Executive function is an umbrella term that includes cognitive processes such as decision-making, impulse control, attention, behavioral flexibility, and working memory. Each of these processes depends largely upon monoaminergic (dopaminergic, serotonergic, and noradrenergic) neurotransmission in the frontal cortex, striatum, and hippocampus, among other brain areas. Traumatic brain injury (TBI) induces disruptions in monoaminergic signaling along several steps in the neurotransmission process - synthesis, distribution, and breakdown - and in turn, produces long-lasting deficits in several executive function domains. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155367PMC
October 2018
4 Reads

Dopamine effects on stress-induced working memory deficits.

Behav Pharmacol 2018 10;29(7):584-591

Faculty of Engineering, University of Birjand, Birjand, Iran.

The prefrontal cortex (PFC) plays a critical role in mediating executive functions and orchestrating the way in which we think, decide, and behave. Many studies have shown that PFC neurons not only play a major role in mediating behavioral responses to stress but are also sensitive to stress and undergo remodeling following stress exposure. Activation of the hypothalamic-pituitary-adrenal axis as a result of stress initiates a flood of alterations in prefrontal neurotransmitter release. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000429DOI Listing
October 2018
2 Reads

Spatial learning and flexibility in 129S2/SvHsd and C57BL/6J mouse strains using different variants of the Barnes maze.

Behav Pharmacol 2018 12;29(8):688-700

School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, UK.

Behavioural flexibility is the ability to switch between tasks and strategies following a change in rules, and involves intact functioning of the medial prefrontal cortex. Impairments of behavioural flexibility have frequently been reported in patients with schizophrenia and rodents with disruption/dysfunction of the prefrontal cortex. The discovery of a mutation in the disrupted in schizophrenia 1 (DISC1) gene in the 129 mouse strain suggests that these mice may be exploited as a 'naturally occurring' model of schizophrenia. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000433DOI Listing
December 2018
1 Read

Sex differences in the effectiveness of buprenorphine to decrease rates of responding in rhesus monkeys.

Behav Pharmacol 2018 Sep 12. Epub 2018 Sep 12.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.

Sex differences in μ-opioid receptor (MOR) agonist-induced antinociception have been reported in nonhuman primates. The degree to which μ-opioid receptor agonist sex differences in nonhuman primates extend to other behavioral endpoints remains unknown. The present study compared the behavioral effects of three MOR ligands (fentanyl, buprenorphine, and naltrexone) that varied in efficacy to stimulate [S]-GTPγS binding (from highest to lowest: fentanyl, buprenorphine, and naltrexone) in male and female rhesus monkeys. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414288PMC
September 2018
2 Reads