2,350 results match your criteria Behavioural Pharmacology[Journal]


Sequential habituation to space, object and stranger is differentially modulated by glutamatergic, cholinergic and dopaminergic transmission.

Behav Pharmacol 2020 Jul 7. Epub 2020 Jul 7.

School of Medicine, Medical Sciences & Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.

Novel object and social interaction tasks allow assessments of rodent cognition and social behavior. Here, we combined these tasks and defined unequivocal locations of interest. Our procedure, termed OF-NO-SI, comprised habituation to the open field (OF), novel object (NO) and social interaction (SI) stages. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000573DOI Listing

Partial and full deletion of nicotinic acetylcholine receptor α4 and β2 subunits reduces sensitivity to acute nicotine administration and development of tolerance following chronic nicotine administration.

Behav Pharmacol 2020 Jun 17. Epub 2020 Jun 17.

Institute for Behavioral Genetics.

The diversity of nicotinic cholinergic receptor (nAChR) subunits underlies the complex responses to nicotine. Mice differing in the expression of α4 and β2 subunits, which are most widely expressed in brain, were evaluated for the responses to acute nicotine administration on Y-maze crossings and rears, open-field locomotion and body temperature following chronic treatment with nicotine (0, 0.25, 1. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000575DOI Listing

Roflumilast attenuates cognitive deficits in estrogen insufficient rats.

Behav Pharmacol 2020 Jun 8. Epub 2020 Jun 8.

Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.

Estrogen replacement therapy including specific estrogen receptor alpha (ERα) agonist, 4,4',4″-(4-propyl-[1H] pyrazole-1,3,5-triyl) trisphenol (PPT), improves cognitive function in the females with estrogen insufficiency condition. It is well suggested that the cyclic nucleotides are considered as one of the downstream mediators to ERα receptor activity and they can be hypothesized as a potential target in the management of estrogen insufficiency condition. Roflumilast, a phosphodiesterase-4 inhibitor, increases the level of cyclic adenosine monophosphate (cAMP) in most of the tissues including the brain, and is reported to have procognitive activity in the experimental animals. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000574DOI Listing

Crossover associations of alcohol and smoking, craving and biochemically verified alcohol and nicotine use in heavy drinking smokers.

Behav Pharmacol 2020 Jun 8. Epub 2020 Jun 8.

Program of Excellence in Addictions Research.

Objectives: This study examined associations between drinking and smoking prior to treatment (biochemically measured at baseline), alcohol and tobacco craving, and biochemical alcohol and tobacco use during the analog trial period.

Methods: We conducted a secondary data analysis of a randomized clinical analog trial where participants with a Diagnostic and Statistical Manual, Fourth Edition Text Revision (DSM-IV-TR) diagnosis of alcohol dependence, abuse or reported heavy drinking, with a co-occurring DSM-IV-TR diagnosis of nicotine dependence, abuse or reported heavy use, who were not seeking treatment were recruited. A generalized estimation equation model for longitudinal binary outcomes was created (N = 34) to determine the predictive effects of baseline tobacco use, alcohol craving, and tobacco craving on alcohol use over the 4 weeks of the trial. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000568DOI Listing

Repeated ketamine administration induces recognition memory impairment together with morphological changes in neurons from ventromedial prefrontal cortex, dorsal striatum, and hippocampus.

Behav Pharmacol 2020 May 29. Epub 2020 May 29.

Escuela Superior de Medicina, Instituto Politécnico Nacional.

Ketamine is an anesthetic agent that antagonizes N-methyl-d-aspartate receptors, inducing psychotic-like symptoms in healthy humans and animals. This agent has been used as a pharmacological tool for studying biochemical and physiological mechanisms underlying the clinical manifestations of schizophrenia. The main goal of this study was to evaluate the effect of repeated injections of ketamine (5 and 10 mg/kg, i. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000571DOI Listing

Blockage of ventrolateral periaqueductal gray matter cannabinoid 1 receptor increases dental pulp pain and pain-related subsequent learning and memory deficits in rats.

Behav Pharmacol 2020 May 29. Epub 2020 May 29.

Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Cannabinoid 1 receptor (CB1R) signaling has a pivotal role in the modulation of both pain and cognitive responses. This study aims at investigating the role of CB1R in the ventrolateral periaqueductal gray matter (vlPAG) on both pulpal pain and pain-related subsequent changes in learning and memory performances in rats. The adult male Wistar rats were cannulated in the vlPAG. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000566DOI Listing

Cannabidiol disrupts conditioned fear expression and cannabidiolic acid reduces trauma-induced anxiety-related behaviour in mice.

Behav Pharmacol 2020 May 29. Epub 2020 May 29.

Lambert Initiative for Cannabinoid Therapeutics.

The major phytocannabinoid cannabidiol (CBD) has anxiolytic properties and lacks tetrahydrocannabinol-like psychoactivity. Cannabidiolic acid (CBDA) is the acidic precursor to CBD, and this compound appears more potent than CBD in animal models of emesis, pain and epilepsy. In this short report, we aimed to examine whether CBDA is more potent than CBD in disrupting expression of conditioned fear and generalised anxiety-related behaviour induced by Pavlovian fear conditioning. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000565DOI Listing

Exploratory analyses of postanesthetic effects of desflurane using behavioral test battery of mice.

Behav Pharmacol 2020 May 25. Epub 2020 May 25.

Departments of Anesthesiology.

Halogenated ethers, such as desflurane, sevoflurane, and isoflurane, are known to exert an array of effects besides sedation. However, the postanesthetic effects of desflurane remain undiscovered as no study has explored these effects systematically. Phenotypic screening using behavioral test batteries is a powerful method to identify such effects. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000567DOI Listing

The role of glutamate receptors and their interactions with dopamine and other neurotransmitters in the development of tardive dyskinesia: preclinical and clinical results.

Behav Pharmacol 2020 May 25. Epub 2020 May 25.

Center of Functionally Integrative Neuroscience (CFIN), University of Aarhus, 8000 Aarhus, Denmark.

Tardive dyskinesia is a serious, disabling, movement disorder associated with the ongoing use of antipsychotic medication. Current evidence regarding the pathophysiology of tardive dyskinesia is mainly based on preclinical animal models and is still not completely understood. The leading preclinical hypothesis of tardive dyskinesia development includes dopaminergic imbalance in the direct and indirect pathways of the basal ganglia, cholinergic deficiency, serotonin receptor disturbances, neurotoxicity, oxidative stress, and changes in synaptic plasticity. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000563DOI Listing

The influence of the duration of chronic unpredictable mild stress on the behavioural responses of C57BL/6J mice.

Behav Pharmacol 2020 May 18. Epub 2020 May 18.

Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.

The chronic unpredictable mild stress (CUMS) model of depression in mice is a model commonly used to investigate stress-induced depressive-like behaviours. The duration of the stress-inducing procedure is variable, thus making it difficult to compare results and draw general conclusions from different protocols. Here, we decided to investigate how the duration of the CUMS procedure affects behavioural changes, body weight as well as the level of plasma corticosterone in stressed and nonstressed C57BL/6J mice subjected to CUMS for 18 or 36 days. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000564DOI Listing

Trait specific modulatory effects of caffeine exposure on compulsive-like behaviors in a spontaneous mouse model of obsessive-compulsive disorder.

Behav Pharmacol 2020 May 13. Epub 2020 May 13.

Department of Biology & Wildlife, University of Alaska Fairbanks, Fairbanks, Alaska, USA.

Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by recurring intrusive thoughts and repetitive compulsive behaviors, ultimately interfering with their quality of life. The complex heterogeneity of symptom dimensions across OCD patient subgroups impedes diagnosis and treatment. The core and comorbid symptomologies of OCD are thought to be modulated by common environmental exposures such as consumption of the psychostimulant caffeine. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000570DOI Listing

Repeated nicotine vapor inhalation induces behavioral sensitization in male and female C57BL/6 mice.

Behav Pharmacol 2020 Apr 13. Epub 2020 Apr 13.

Department of Psychological Science, Weber State University, Ogden, Utah, USA.

Electronic cigarette use has significantly increased over the past decade. However, there is limited preclinical research on the behavioral and abuse-related effects of nicotine vapor inhalation in rodents. The present study evaluates the effects of repeated nicotine vapor inhalation in male and female mice using a nicotine behavioral sensitization model. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000562DOI Listing

The discriminative stimulus effects of epibatidine in C57BL/6J mice.

Behav Pharmacol 2020 Mar 23. Epub 2020 Mar 23.

Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.

The α4β2* nicotinic acetylcholine receptor (nAChR) subtypes are targeted for the development of smoking cessation aids, and the use of drug discrimination in mice provides a robust screening tool for the identification of drugs acting through nAChRs. Here, we established that the α4β2* nAChR agonist epibatidine can function as a discriminative stimulus in mice. Male C57BL/6J mice discriminated epibatidine (0. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000555DOI Listing

Response to opioids is dependent on sociability levels.

Behav Pharmacol 2020 04;31(2&3):293-307

Behavioral and Cellular Neuroscience, Department of Psychological and Brain Sciences, Texas A&M University, College Station, Texas, USA.

Social environment influences the trajectory of developing opioid use disorder (OUD). Thus, the present study tested the hypothesis that sociability levels will affect the responses to opioids. Mice were tested for their baseline sociability, anxiety levels, pain sensitivities, and their acute locomotor response to 5 mg/kg opioids. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000552DOI Listing

Kissorphin improves spatial memory and cognitive flexibility impairment induced by ethanol treatment in the Barnes maze task in rats.

Behav Pharmacol 2020 04;31(2&3):272-282

Department of Pharmacology and Pharmacodynamics, Medical University, Lublin, Poland.

Acute and chronic ethanol intake, as well as ethanol withdrawal, exert learning disabilities. Of all the neurotransmitters in the brain, endogenous opioid peptides are thought to participate in ethanol effects. Kisspeptins, including kisspeptin-10, are peptides produced in the part of brain involved in the consolidation of memory and orientation. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000557DOI Listing

The antinociceptive effects of a dual kappa-delta opioid receptor agonist in the mouse formalin test.

Behav Pharmacol 2020 04;31(2&3):174-178

Department of Pharmacology and Toxicology and Translational Research Initiative for Pain and Neuropathy, Virginia Commonwealth University, Virginia Commonwealth University, Richmond, Virginia.

Pain management is a challenging and unmet medical need. Despite their demonstrated efficacy, currently used opioid drugs and nonsteroidal anti-inflammatory drugs are frequently associated with several adverse events. The identification of new and safe analgesics is therefore needed. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080317PMC

Peripherally acting opioid analgesics and peripherally-induced analgesia.

Behav Pharmacol 2020 04;31(2&3):136-158

Área de Farmacología y Nutrición, Departamento de Ciencias Básicas de la Salud, Universidad Rey Juan Carlos (URJC), Alcorcón.

The management of pain, particularly chronic pain, is still an area of medical need. In this context, opioids remain a gold standard for the treatment of pain. However, significant side effects, mainly of central origin, limit their clinical use. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000558DOI Listing

Opioid system modulation of cognitive affective bias: implications for the treatment of mood disorders.

Behav Pharmacol 2020 04;31(2&3):122-135

Alkermes, Inc., Biology, Waltham, Massachusetts, USA.

A significant number of patients (30%) do not adequately respond to commonly prescribed antidepressants (e.g. SSRIs, SNRIs, and TCAs). Read More

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http://dx.doi.org/10.1097/FBP.0000000000000559DOI Listing
April 2020
2.148 Impact Factor

The behavioural pharmacology of opioids.

Authors:

Behav Pharmacol 2020 04;31(2&3):109-111

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http://dx.doi.org/10.1097/FBP.0000000000000560DOI Listing

Preference for vigorous exercise versus sedentary sucrose drinking: an animal model of anergia induced by dopamine receptor antagonism.

Behav Pharmacol 2020 Mar 4. Epub 2020 Mar 4.

Department of Psychology, University of Connecticut, Storrs, Connecticut.

Motivation has activational and directional components. Mesolimbic dopamine is critical for the regulation of behavioral activation and effort-related processes in motivated behaviors. Impairing mesolimbic dopamine function leads to fatigue and anergia, but leaves intact other aspects of reinforce seeking behaviors, such as the consummatory or hedonic component. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000556DOI Listing

Effects of naltrexone on alcohol, sucrose, and saccharin binge-like drinking in C57BL/6J mice: a study with a multiple bottle choice procedure.

Behav Pharmacol 2020 04;31(2&3):256-271

Area de Psicobiología, Universitat Jaume I, Castellón, Spain.

Chronic alcohol (ethyl alcohol, EtOH) binging has been associated with long-term neural adaptations that lead to the development of addiction. Many of the neurobiological features of EtOH abuse are shared with other forms of binging, like pathological feeding. The drinking-in-the-dark (DID) paradigm has been used extensively to study the neurobiology of EtOH binge-like drinking due to its ability to promote high intakes relevant to human behavior. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101028PMC

Effects of opioid/cannabinoid mixtures on impulsivity and memory in rhesus monkeys.

Behav Pharmacol 2020 04;31(2&3):233-248

Departments of Pharmacology.

The opioid epidemic underscores the need for safer and more effective treatments for pain. Combining opioid receptor agonists with drugs that relieve pain through nonopioid mechanisms could be a useful strategy for reducing the dose of opioid needed to treat pain, thereby reducing risks associated with opioids alone. Opioid/cannabinoid mixtures might be useful in this context; individually, opioids and cannabinoids have modest effects on cognition, and it is important to determine whether those effects occur with mixtures. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122694PMC

The synthetic cathinone 3,4-methylenedioxypyrovalerone increases impulsive action in rats.

Behav Pharmacol 2020 Jun;31(4):309-321

Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

A previous study from our laboratory has shown that the selective catecholamine reuptake inhibitor 3,4-methylenedioxypyrovalerone (MDPV) persistently alters impulsive choice as measured by delay discounting. To further understand the proimpulsive effects of MDPV, we examined its capacity to modulate a different impulsive measure - impulsive action - using a differential reinforcement of low rates of responding task with an inter-response time of 20 s. Three groups of male, Sprague-Dawley rats (n = 6) were first tested in daily sessions to understand the acute effects of cocaine (1. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000548DOI Listing

Effects of dose on acquisition and persistence of a new response for a remifentanil-associated stimulus.

Behav Pharmacol 2020 04;31(2&3):207-215

Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.

Previous research demonstrated that a remifentanil-associated stimulus facilitated the acquisition of a previously unlearned response; however, it is unclear how long a remifentanil-associated stimulus maintains conditioned reinforcing properties under conditions of daily testing. To address this gap, we exposed adult male rats to response-independent stimulus presentations and deliveries of remifentanil (1.0, 3. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071955PMC

D1- but not D2-like dopamine receptor antagonist in the CA1 region of the hippocampus reduced stress-induced reinstatement in extinguished morphine-conditioning place preference in the food-deprived rats.

Behav Pharmacol 2020 04;31(2&3):196-206

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences.

Relapsing to drugs of abuse is a challenging problem in treatment of addiction and stress is believed to be a major risk factor in relapse to drugs. The hippocampus region and dopamine signaling play a critical role in reward-related behaviors. The purpose of this study is to identify the involvement of D1- and D2-like receptors in the CA1 region of hippocampus in the reinstatement induced by a combination of food deprivation stress and a sub-threshold dose of morphine in extinguished morphine-conditioning place preference in rats. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000546DOI Listing

Heightened reward response is associated with HCN2 overexpression in the ventral tegmental area in morphine-sensitized rats.

Behav Pharmacol 2020 04;31(2&3):283-292

Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.

Morphine sensitization is associated with increased locomotion and stereotypies in rats. This persistent condition has been proposed as a model of manic-like symptoms. Modifications in reward threshold are considered a central feature of mania and have been related to changes in mesocorticolimbic dopaminergic transmission. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000545DOI Listing

Glucocorticoid and brain-derived neurotrophic factor relationship: a brief investigation into the model of depression by chronic administration of corticosterone.

Behav Pharmacol 2020 Jun;31(4):407-412

Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria (RS), Brazil.

Depression is considered a common mental disorder that affects more than 300 million people worldwide. Despite this high incidence, its etiology is not completely elucidated instigating further studies. For this purpose, different animal models are used to study routes and molecular changes involved in depression, among them the chronic administration of corticosterone. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000547DOI Listing

Morus nigra leaves extract revokes the depressive-like behavior, oxidative stress, and hippocampal damage induced by corticosterone: a pivotal role of the phenolic syringic acid.

Behav Pharmacol 2020 Jun;31(4):397-406

Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, Blumenau, Santa Catarina, Brazil.

The pathophysiology of depression includes glucocorticoids excess, glutamatergic excitotoxicity, and oxidative stress impairment. Previous study demonstrated Morus nigra L. leaves extract and syringic acid (4-hydroxy-3,5-dimethoxybenzoic acid), its major phenolic compound, administered orally for 7 days, decreased the immobility time in the tail suspension test, without locomotor alteration. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000549DOI Listing

Combined effects of mephedrone and cocaine on locomotor activity and conditioned place preference in male Sprague-Dawley rats.

Behav Pharmacol 2020 Jun;31(4):368-377

Department of Psychology, Western Michigan University, Kalamazoo, Michigan, USA.

Mephedrone (MEPH) is one of several synthetic cathinone derivatives and a common constituent of illicit 'bath salts'. Concomitant use of MEPH with other psychostimulants is common among recreational users, but their combined effects have not been evaluated rigorously. In experiment 1, 56 male Sprague-Dawley rats were administered saline, MEPH (1 or 5 mg/kg), COC (5 mg/kg), or a mixture of MEPH (1 or 5 mg/kg) + COC (5 mg/kg) for seven consecutive days. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000539DOI Listing

Neuroprotective effect of chronic administration of cannabidiol during the abstinence period on methamphetamine-induced impairment of recognition memory in the rats.

Behav Pharmacol 2020 Jun;31(4):385-396

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Neuropsychiatric disorders, such as addiction, are associated with cognitive impairment, including learning and memory deficits. Previous research has demonstrated that the chronic use of methamphetamine (METH) induces long-term cognitive impairment and cannabidiol (CBD), as a neuroprotectant, can reverse spatial memory deficits induced by drug abuse. The study aimed to evaluate the effect of CBD on METH-induced memory impairment in rats chronically exposed to METH (CEM). Read More

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http://dx.doi.org/10.1097/FBP.0000000000000544DOI Listing

Effects of oxycodone and diazepam alone and in combination on operant nociception.

Behav Pharmacol 2020 04;31(2&3):168-173

Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA.

Developing effective analgesics with fewer unwanted side effects is a pressing concern. Due to a lack of effective nonopioid options currently available, an alternative approach termed opioid-sparing evaluates the ability of a coadministered drug to reduce the amount of opioid needed to produce an antinociceptive effect. Opioids and benzodiazepines are often coprescribed. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000542DOI Listing

Protective role of functional food in cognitive deficit in young and senile rats.

Behav Pharmacol 2020 02;31(1):81-96

Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Cognitive decline and neurodegenerative diseases pose a significant burden on healthcare resources both in developed and developing countries which is a major socio-economic and healthcare concern. Alzheimer's disease is the most common form of progressive neurodegenerative dementia of the aged brain. Aluminum is a constituent of antacids, deodorants, kitchenware and food additives which allows easy access into the body posing risk to development of senile dementia of Alzheimer's type. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000522DOI Listing
February 2020
2.148 Impact Factor

Comparison of the muscarinic antagonist effects of scopolamine and L-687,306.

Behav Pharmacol 2020 Jun;31(4):359-367

Department of Pharmacology, University of Texas Health, San Antonio, Texas.

This study aimed to use central and peripheral assays to compare the effects of the muscarinic antagonist scopolamine with those of a novel muscarinic antagonist, L-687,306 [(3R,4R)-3-(3-cyclopropyl-1,2,4,oxadiazol[5-yl]-1-azabicyclo[2.2.1]heptane. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000537DOI Listing

Effects of oxycodone on sensitivity to reinforcement magnitude: implications for effects of opioids on impulsive and risky choice.

Behav Pharmacol 2020 04;31(2&3):221-232

Department of Psychology, University of North Carolina Wilmington, Wilmington, North Carolina, USA.

Opioid addiction/dependence is associated with impulsive and risky behavior. Moreover, opioids can increase impulsive choice in preclinical studies with nonhumans. The objective of this study was to investigate a potential behavioral mechanism of opioids: a change in the impact of reinforcement magnitude on choice. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071999PMC

The contribution of orexin receptors within the ventral tegmental area to modulation of antinociception induced by chemical stimulation of the lateral hypothalamus in the animal model of orofacial pain in the rats.

Behav Pharmacol 2019 Dec 30. Epub 2019 Dec 30.

Neuroscience Research Center, School of Medicine.

Involvement of the ventral tegmental area (VTA) and the lateral hypothalamus (LH) in the modulation of formalin-induced nociception is well documented. In this study, we investigated the role of orexin 1 (OX1) and orexin 2 (OX2) receptors within the VTA in modulation of the LH-induced antinociception during both phases of orofacial formalin test. Male adult Wistar rats weighing 230-250 g were unilaterally implanted with two stainless steel guide cannulae in the VTA and LH. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000531DOI Listing
December 2019

Naturalistic operant responses in deer mice (Peromyscus maniculatus bairdii) and its response to outcome manipulation and serotonergic intervention.

Behav Pharmacol 2020 Jun;31(4):343-358

Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom.

Investigating the motivational triggers underlying naturalistic compulsive-like behavior is generally regarded as challenging. To this extent, the current study aimed to establish a proof-of-concept for future investigation by probing unconditioned and naturalistic operant responses aimed at obtaining nesting material by normal (NNB) and large (LNB) nest building deer mice (Peromyscus maniculatus bairdii). LNB mice and NNB controls were individually placed in cages equipped with a lever-operated nesting material (cotton rope) dispenser and allowed to become accustomed to the response (lever press)-outcome (obtaining cotton rope) contingency over seven nights. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000536DOI Listing

Evaluation of the antidepressive property of β-hydroxybutyrate in mice.

Behav Pharmacol 2020 Jun;31(4):322-332

Department of Respiratory Medicine, Nantong First People's Hospital, the Second Affiliated Hospital of Nantong University, Nantong.

β-hydroxybutyrate, a ketone body metabolite, has been shown to suppress depression-like behavior in rodents. In this study, we examined its antidepressive property in acute and chronic administration modes in mice by using forced swim test and tail suspension test. Results showed that the decrease effect of β-hydroxybutyrate (300 mg/kg) on immobility time in the tail suspension test and forced swim test in stress-naive mice began to be significant at day 11. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000535DOI Listing

Methylenedioxymethamphetamine-like discriminative stimulus effects of seven cathinones in rats.

Behav Pharmacol 2020 Jun;31(4):378-384

Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.

Synthetic cathinone derivatives are commonly considered quasi-legal alternatives for stimulant drugs, such as cocaine and methamphetamine, but some derivatives are increasingly being detected in club drug formulations of Ecstasy or 'Molly' as substitutes for methylenedioxymethamphetamine (±-MDMA). Although several studies have evaluated the psychostimulant-like effects of synthetic cathinones, few cathinone compounds have been assessed for MDMA-like activity. In order to determine their likelihood of interchangeability with entactogenic club drugs, the discriminative stimulus effects of methcathinone, 4-fluoromethcathinone, 4-methylmethcathinone, 4-methylethcathinone, 3-fluoromethcathinone, pentedrone, and ethylone were assessed in Sprague-Dawley rats trained to discriminate 1. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000540DOI Listing

The role of the gut microbiome in opioid use.

Behav Pharmacol 2020 04;31(2&3):113-121

Department of Pharmaceutical Sciences, University of California.

Although the gut and brain are separate organs, they communicate with each other via trillions of intestinal bacteria that collectively make up one's gut microbiome. Findings from both humans and animals support a critical role of gut microbes in regulating brain function, mood, and behavior. Gut bacteria influence neural circuits that are notably affected in addiction-related behaviors. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000538DOI Listing

A valepotriate-enriched fraction from Valeriana glechomifolia decreases DNA methylation and up-regulate TrkB receptors in the hippocampus of mice.

Behav Pharmacol 2020 Jun;31(4):333-342

Faculty of Pharmacy, Laboratory of Experimental Psychopharmacology, Graduate Studies Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre - RS.

DNA methylation, an epigenetic modification that mediates gene silencing, has been shown to play a role in the neurobiology of major depression. Studies suggested that terpenes inhibit DNA methylation and increase gene expression. The present study investigated the involvement of DNA methylation in the antidepressant-like activity of diene valepotriates, non-glicosilated carbocyclic iridoids that comprise a family of terpenes obtained from Valeriana glechomifolia. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000534DOI Listing

Pain and stress: functional evidence that supra-spinal mechanisms involved in pain-induced analgesia mediate stress-induced analgesia.

Behav Pharmacol 2020 04;31(2&3):159-167

Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba.

Analgesia induced by stressful and painful stimuli is an adaptive response during life-threatening situations. There is no evidence linking the mechanisms underlying them, while the former depends on the activation of stress-related brain pathways, the second depends on opioidergic mechanisms in the nucleus accumbens and on nicotinic cholinergic mechanisms in the rostral ventromedial medulla. In this study, we hypothesized that stress-induced analgesia is also dependent on opioidergic mechanisms in the nucleus accumbens and on nicotinic cholinergic mechanisms in the rostral ventromedial medulla. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000529DOI Listing

Metoprolol decreases retention of fear memory and facilitates long-term depression in lateral amygdala.

Behav Pharmacol 2019 Dec 18. Epub 2019 Dec 18.

Department of Neurology, The First People's Hospital of Jingzhou, the First Affiliated Hospital of Yangtze University, Jingzhou, China.

Posttraumatic stress disorder is a mental disorder with a known cause, yet effective behavioral and pharmacotherapies remain elusive for many afflicted patients. Propranolol is suggested to be effective as a fear-reducing agent when paired with behavioral therapy soon after trauma when psychological stress is high, possibly dampening or preventing the later development of posttraumatic stress disorder. In our previous study, we found propranolol efficaciously reduced fear retention induced by reactivation via β-adrenergic receptors in lateral amygdala. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000533DOI Listing
December 2019

Antipsychotic-like profile of CIQ isomers in animal models of schizophrenia.

Behav Pharmacol 2019 Dec 18. Epub 2019 Dec 18.

Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, India.

Earlier, we have shown the efficacy of racemic (±) CIQ, a positive allosteric modulator of GluN2C/2D receptor against MK-801 induced impairment of prepulse inhibition as well as working memory. The present study investigated the antipsychotic-like profile of different CIQ (±, +, -) isomers against schizophrenia-like symptoms in series of behavioural animal models like apomorphine climbing, social isolation behaviour and NMDA receptor antagonist MK-801 induced cognitive deficits. Further, we also tested CIQ (±, +, -) isomers in neurodevelopmental model against MK-801induced deficits using open field test, Y-maze test and novel object recognition test. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000532DOI Listing
December 2019

Novel pharmacological modulation of dystonic phenotypes caused by a gain-of-function mutation in the Na+ leak-current channel.

Behav Pharmacol 2019 Dec 14. Epub 2019 Dec 14.

Department of Pharmacology, Toxicology and Neuroscience.

The Na leak-current channel (NALCN) regulates the resting membrane potential in excitable cells, thus determining the likelihood of depolarization in response to incoming signals. Gain-of-function (gf) mutations in this channel are associated with severe dystonic movement disorders in man. Currently, there are no known pharmacological antagonists or selective modulators of this important channel. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000526DOI Listing
December 2019

Cerebrolysin enhances the expression of the synaptogenic protein LRRTM4 in the hippocampus and improves learning and memory in senescent rats.

Behav Pharmacol 2019 Dec 14. Epub 2019 Dec 14.

Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México.

Aging reduces the efficiency of the organs and systems, including the cognitive functions. Brain aging is related to a decrease in the vascularity, neurogenesis, and synaptic plasticity. Cerebrolysin, a peptide and amino acid preparation, has been shown to improve the cognitive performance in animal models of Alzheimer's disease. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000530DOI Listing
December 2019

An overview on transient receptor potential channels superfamily.

Behav Pharmacol 2019 Dec 10. Epub 2019 Dec 10.

Laboratory of Pain and Analgesia, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia.

The transient receptor potential (TRP) channel superfamily is comprised of a large group of cation-permeable channels, which display an extraordinary diversity of roles in sensory signaling and are involved in plethora of animal behaviors. These channels are activated through a wide variety of mechanisms and participate in virtually every sensory modality. Modulating TRP channel activity provides an important way to regulate membrane excitability and intracellular calcium levels. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000524DOI Listing
December 2019
2.148 Impact Factor

Comparison of chemotherapy effects on mechanical sensitivity and food-maintained operant responding in male and female rats.

Behav Pharmacol 2019 Dec 10. Epub 2019 Dec 10.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.

Chemotherapies of varying classes often cause neuropathy and debilitating chemotherapy-induced neuropathic pain sufficient to limit treatment and reduce quality of life for many patients battling cancer. There are currently no effective preventive or alleviative treatments for chemotherapy-induced neuropathic pain. Preclinical models have been developed to test candidate chemotherapy-induced neuropathic pain treatments; however, studies using these models rarely provide direct comparisons of effects of different chemotherapies or assess the degree to which chemotherapies produce clinically relevant signs of pain-depressed behavior. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000527DOI Listing
December 2019

Sensation seeking, sexual orientation, and drug abuse symptoms in a community sample of emerging adults.

Behav Pharmacol 2020 02;31(1):102-107

Department of Psychological and Brain Sciences, Texas A&M University.

Increased use of drugs is associated with a number of factors including high sensation seeking and sexual minority status (through group-specific minority stress). We sought to examine how personality traits like sensation seeking may influence drug abuse among sexual minority individuals. Participants were 217 emerging adults (Mage = 20. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000523DOI Listing
February 2020

Equal response rates maintained by concurrent drug and nondrug reinforcers: a design for treatment evaluation.

Behav Pharmacol 2019 Nov 25. Epub 2019 Nov 25.

Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston.

During daily 3-h sessions, four rhesus monkeys had concurrent access to 16% alcohol (w/v) and saccharin. A response occurred when a monkey made mouth contact with the metal spout and thereby completed a drinkometer circuit. The liquids were available under concurrent nonindependent fixed-ratio 32 schedules. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000525DOI Listing
November 2019