Daily maternal separations during stress hyporesponsive period decrease the thresholds of panic-like behaviors to electrical stimulation of the dorsal periaqueductal gray of the adult rat.
- Ana Cristina Borges-Aguiar,
- Luana Zanoni Schauffer,
- Edo Ronald de Kloet,
- Luiz Carlos Schenberg
Behav Brain Res 2018 Feb 18. Epub 2018 Feb 18.
Department of Physiological Sciences, Health Science Center, Federal University of EspíritoSanto, Brazil. Electronic address:
The present study examined whether early life maternal separation (MS), a model of childhood separation anxiety, predisposes to panic at adulthood. For this purpose, male pups were submitted to 3-h daily maternal separations along postnatal (PN) days of either the 'stress hyporesponsive period' (SHRP) from PN4 to PN14 (MS11) or throughout lactation from PN2 to PN21 (MS20). Pups were further reunited to conscious (CM) or anesthetized (AM) mothers to assess the effect of mother-pup interaction upon reunion. Read More