11,794 results match your criteria Behavioural Brain Research [Journal]


Behavioral profile of intermittent vs continuous access to a high fat diet during adolescence.

Behav Brain Res 2019 Apr 19. Epub 2019 Apr 19.

Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de València, Avda. Blasco Ibáñez, 21, 46010 Valencia, Spain. Electronic address:

Over the past few years, the effects of a high-fat diet (HFD) on cognitive functions have been broadly studied as a model of obesity, although no studies have evaluated whether these effects are maintained after the cessation of this diet. In addition, the behavioral effects of having a limited access to an HFD (binge-eating pattern) are mostly unknown, although they dramatically increase the vulnerability to drug use in contrast to having continuous access. Thus, the aim of the present study was to compare the effects of an intermittent versus a continuous exposure to an HFD during adolescence on cognition and anxiety-like behaviors, as well as to study the changes observed after the interruption of this diet. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.04.005DOI Listing

Spatial T-maze identifies cognitive deficits in piglets 1 month after hypoxia-ischemia in a model of hippocampal pyramidal neuron loss and interneuron attrition.

Behav Brain Res 2019 Apr 19:111921. Epub 2019 Apr 19.

Johns Hopkins University (JHU), Department of Anesthesiology and Critical Care Medicine, Baltimore, MD, United States. Electronic address:

Neonatal brain injury from hypoxia-ischemia (HI) causes major morbidity. Piglet HI is an established method for testing neuroprotective treatments in large, gyrencephalic brain. Though many neurobehavior tests exist for rodents, such tests and their associations with neuropathologic injury remain underdeveloped and underutilized in large, neonatal HI animal models. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111921DOI Listing

Responsivity of Lateral Septum-mPFC Connections in Alloxan-induced Hyperglycemia.

Behav Brain Res 2019 Apr 18:111919. Epub 2019 Apr 18.

Área de Biomedicina, Instituto de Investigaciones Biológicas, Universidad Veracruzana, Xalapa, Veracruz, 91190, Mexico.

The lateral septal nucleus (LSN) is related to the actions of antidepressants, and the prelimbic cortex (PL) and infralimbic cortex (IL) modulate responses to fear. However, unknown is whether experimental diabetes that is induced by alloxan alters the responsivity of these regions. We used a method in which one forebrain region (LSN) was electrically stimulated while single-unit extracellular recordings were performed in another mPFC region (PL and IL). Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111919DOI Listing

Corrigendum to "FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia" [Behav. Brain Res. 356 (2019) 98-106].

Behav Brain Res 2019 Apr 18:111839. Epub 2019 Apr 18.

Department of Neurology, Hebei Medical University, No. 361 Zhongshan East Road, Changan District, Shijiazhuang, 050017, Hebei Province, People's Republic of China; Department of Neurology, Hebei General Hospital, No. 348 Heping West Road, Xinhua District, Shijiazhuang, 050051, Hebei Province, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01664328193033
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http://dx.doi.org/10.1016/j.bbr.2019.03.008DOI Listing
April 2019
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The effects of short-term and long-term environmental enrichment on locomotion, mood-like behavior, cognition and hippocampal gene expression.

Behav Brain Res 2019 Apr 17:111917. Epub 2019 Apr 17.

Psychiatric Neuroscience Lab, Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia. Electronic address:

Background: Environmental enrichment (EE) has been shown to modulate behavior and hippocampal gene expression; however, the currently available literature does not explain the differential effects that may relate to the duration of EE.

Aim: To investigate the differential effects of short- and long-term EE on locomotion, anxiety-, depressive- and cognition-like behaviors, and hippocampal gene expression under physiological conditions.

Methods: We assigned either short-term or long-term intervention with respective controls to healthy C57BL/6 mice (n = 12-16/group). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328183174
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http://dx.doi.org/10.1016/j.bbr.2019.111917DOI Listing
April 2019
2 Reads

Tauopathy in the periaqueductal gray, kölliker-fuse nucleus and nucleus retroambiguus is not predicted by ultrasonic vocalization in tau-P301L mice.

Behav Brain Res 2019 Apr 17:111916. Epub 2019 Apr 17.

The Florey Institute of Neuroscience and Mental Health, Discovery Neuroscience theme, Australia. Electronic address:

Upper airway and vocalization control areas such as the periaqueductal gray (PAG), kölliker-fuse nucleus (KF) and nucleus retroambiguus (NRA) are prone to developing tauopathy in mice expressing the mutant human tau P301 L protein. Consequently, impaired ultrasonic vocalization (USV) previously identified in tau-P301 L mice at the terminal disease stage of 8-9 months of age, was attributed to the presence of tauopathy in these regions. Our aim was to establish whether the onset of USV disorders manifest prior to the terminal stage, and if USV disorders are predictive of the presence of tauopathy in the PAG, KF and NRA. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111916DOI Listing

Age, but not severity of injury, mediates decline in executive function: Validation of the rodent touchscreen paradigm for preclinical models of traumatic brain injury.

Behav Brain Res 2019 Apr 15:111912. Epub 2019 Apr 15.

Cognition, Ageing and Neurodegenerative Disease Lab, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5005 Australia. Electronic address:

Increasingly, it is being recognised that traumatic brain injury (TBI) is not just an acute event but instead results in ongoing neuronal injury that may lead to chronic impairments in multiple cognitive domains. Of these, deficits in executive function are one of the more common changes reported following TBI, and are a major predictor of well-being, social function and quality of life in individuals with a history of TBI. In order to fully understand the relationship between TBI and executive dysfunction, including brain mechanisms that may account for this, experimental models are clearly needed. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111912DOI Listing

Anhedonia following mild traumatic brain injury in rats: A behavioral economic analysis of positive and negative reinforcement.

Behav Brain Res 2019 Apr 15:111913. Epub 2019 Apr 15.

NeuroBehavioral Research Lab, Department of Veteran Affairs Medical Center, New Jersey Health Care System, East Orange, New Jersey, USA; Department of Pharmacology, Physiology and Neurosciences, New Jersey Medical School - Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA; Graduate School of Biomedical Sciences, New Jersey Medical School-Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA. Electronic address:

Psychiatric disorders affect nearly 50% of individuals who have experienced a traumatic brain injury (TBI). Anhedonia is a major symptom of numerous psychiatric disorders and is a diagnostic criterion for depression. It has recently been appreciated that reinforcement may be separated into consummatory (hedonic), motivational and decisional components, all of which may be affected differently in disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328193034
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http://dx.doi.org/10.1016/j.bbr.2019.111913DOI Listing
April 2019
2 Reads

Physical activity sustains memory retrieval in dopamine-depleted mice previously treated with L-Dopa.

Behav Brain Res 2019 Apr 15:111915. Epub 2019 Apr 15.

Department of Neurology, Charité-Universitätsmedizin, Charitéplatz 1, 10117, Berlin, Germany. Electronic address:

The neurodegenerative disorder Parkinson's disease affects motor abilities as well as cognition. The gold standard therapy is L-Dopa, which mainly restores motor skills. Therefore, we require additional interventions to sustain cognitive functions in Parkinson's disease. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111915DOI Listing

A search for cortical correlates of trait impulsivity in Parkinson´s Disease.

Behav Brain Res 2019 Apr 13:111911. Epub 2019 Apr 13.

Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany.

Background: Impulsivity is an enduring personality trait that is highly relevant for the development of neuropsychiatric disorders. Although impulse control disorders (ICD) are well-characterized non-motor features in Parkinson's disease (PD), mainly related to medication, little is known about neural correlates reflecting trait aspects of impulsivity in PD patients. Here, we address the question whether motor, attentional and non-planning components, measured by the Barratt Impulsiveness Scale (BIS-11), are distinctly related to cortical thickness and cortical folding abnormalities in PD when compared to age-matched healthy controls (HC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328193001
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http://dx.doi.org/10.1016/j.bbr.2019.111911DOI Listing
April 2019
3 Reads

Investigating the reciprocal relationships between locomotor sensitization to ethanol and PTSD-like clusters in DBA/2J mice.

Behav Brain Res 2019 Apr 12:111909. Epub 2019 Apr 12.

Psychology & Neuroscience of Cognition - PsyNCogn, ULiège, Belgium. Electronic address:

Background: Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are two conditions that co-occur frequently. The mechanistic explanations of this co-morbidity are still unclear. The goal of this study was twofold. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328183146
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http://dx.doi.org/10.1016/j.bbr.2019.111909DOI Listing
April 2019
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Spontaneous and light-induced lateralization of immediate early genes expression in domestic chicks.

Behav Brain Res 2019 Apr 12. Epub 2019 Apr 12.

Center for Mind/Brain Sciences, University of Trento, Corso Bettini 31, 38068 Rovereto (TN), Italy. Electronic address:

Exposure of domestic chicks' eggs to light during embryo incubation stimulates asymmetrically the two eye-systems, reaching selectively the right eye (left hemisphere) and inducing asymmetries at the behavioral and neural level. Surprisingly, though, some types of lateralization have been observed also in dark incubated chicks, especially at the behavioral level. Here we investigate the mechanisms subtending the development of lateralization, in the presence and in the absence of embryonic light exposure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328193027
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http://dx.doi.org/10.1016/j.bbr.2019.111905DOI Listing
April 2019
2 Reads

Maternal manipulation during late gestation (GDs 17-20) enhances ethanol consumption and promotes changes and opioid mRNA expression in infant rats.

Behav Brain Res 2019 Apr 12;368:111908. Epub 2019 Apr 12.

Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, C.P. 5000, Argentina; Instituto de Investigaciones Psicológicas (IIPsi-CONICET-UNC), Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, C.P. 5000, Argentina. Electronic address:

Fetal ethanol experience generates learning and memories capable to increase ethanol consummatory behaviors during infancy. Opioid system seems to be involved in mediating those alcohol-related behaviors. In this work, we proposed to study the impact of prenatal exposure to a moderate ethanol dose, upon ingestion of the drug and possible ethanol-induced molecular changes on opioid precursor peptides (POMC, Pro-enk and Pro-DYN) and receptors (MOR, DOR and KOR) mRNA expression, in hypothalamus. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111908DOI Listing

Contribution of sensorimotor beta oscillations during value-based action selection.

Behav Brain Res 2019 Apr 12:111907. Epub 2019 Apr 12.

Department of Psychological and Brain Sciences, University of Massachusetts, Amherst, 01002 MA, USA. Electronic address:

Choosing a course of daily-life actions requires an accurate assessment of the associated risks and potential rewards. We investigated the neural dynamics of this decision process by analyzing the neural electrical signals acquired from electroencephalography (EEG) during a value-based action-selection task. In particular, we determined whether sensorimotor beta oscillations, traditionally studied in the context of motor control, are also involved in value-based decision making for actions. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111907DOI Listing

Disruption of latent inhibition by subchronic phencyclidine pretreatment in rats.

Behav Brain Res 2019 Apr 11:111901. Epub 2019 Apr 11.

Department of Neuroscience, Psychology and Behaviour, University of Leicester, Lancaster Road, Leicester, LE1 9HN, UK. Electronic address:

Repeated subchronic treatment with the NMDA-receptor antagonist, phencyclidine, causes behavioural changes in rats, which resemble cognitive and negative symptoms of schizophrenia. However, its effects on behaviours modelling positive symptoms are less clear. This study investigated whether subchronic phencyclidine pretreatment affected latent inhibition: impaired conditioning following repeated preexposure of the to-be-conditioned stimulus. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111901DOI Listing
April 2019
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Sex differences in fear regulation and reward-seeking behaviors in a fear-safety-reward discrimination task.

Behav Brain Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA. Electronic address:

Reward availability and the potential for danger or safety potently regulate emotion. Despite women being more likely than men to develop emotion dysregulation disorders, there are comparatively few studies investigating fear, safety and reward regulation in females. Here, we show that female Long Evans rats did not suppress conditioned freezing in the presence of a safety cue, nor did they extinguish their freezing response, whereas males did both. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111903DOI Listing
April 2019
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Beneficial effects of (R)-ketamine, but not its metabolite (2R,6R)-hydroxynorketamine, in the depression-like phenotype, inflammatory bone markers, and bone mineral density in a chronic social defeat stress model.

Behav Brain Res 2019 Apr 11;368:111904. Epub 2019 Apr 11.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan. Electronic address:

Inflammatory bone markers may play a role in the antidepressant actions of (R)-ketamine in susceptible mice after chronic social defeat stress (CSDS). In this study, we compared the effects of (R)-ketamine and its final metabolite (2R,6R)-hydroxynorketamine (HNK) in depression-like phenotypes, inflammatory bone markers and bone mineral density (BMD) in CSDS susceptible mice. We measured plasma levels of inflammatory bone markers, which included osteoprotegerin (OPG), receptor activator of nuclear factor κB ligand (RANKL), and osteopontin after behavioral tests. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111904DOI Listing

The presence of elevated circulating trimethylamine N-oxide exaggerates postoperative cognitive dysfunction in aged rats.

Behav Brain Res 2019 Apr 10:111902. Epub 2019 Apr 10.

Department of Anesthesiology, Jinan City, Shandong Province, China. Electronic address:

Surgical trauma can cause brain oxidative stress and neuroinflammation, leading to postoperative cognitive dysfunction (POCD), especially in the elderly. Additionally, the pre-existing risk factors may enhance POCD. Gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) has recently been shown to contribute to the pathogenesis of many diseases by increasing oxidative stress and inflammation in the peripheral tissues. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111902DOI Listing
April 2019
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Affective profiling for anxiety-like behavior in a rodent model of mTBI.

Behav Brain Res 2019 Apr 9. Epub 2019 Apr 9.

Operational and Undersea Medicine Directorate, Department of Neurotrauma, 503 Robert Grant Ave, Naval Medical Research Center, Silver Spring, MD, USA. Electronic address:

Mild traumatic brain injury is a common outcome of blast exposure, and current literature indicates high rates of comorbid posttraumatic stress disorder (PTSD) in military personnel. Blast-exposed rats display PTSD-like behavior, suggesting relationships may exist between PTSD and blast exposure. Other studies demonstrate the roles of stathmin and corticosterone associated with fear- and anxiety-like behaviors in rodent models. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328183149
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http://dx.doi.org/10.1016/j.bbr.2019.04.009DOI Listing
April 2019
3 Reads

Repeated bifenthrin exposure alters hippocampal Nurr-1/AChE and induces depression-like behavior in adult rats.

Behav Brain Res 2019 Apr 9. Epub 2019 Apr 9.

Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Hauptstr. 5, D-79104 Freiburg, Germany. Electronic address:

Exposure to insecticides has been associated with depression-like symptoms, especially among occupationally exposed populations, such as farmers. Although the neurotoxicity of pyrethroids such as bifenthrin (BF) is well established, it is still unclear whether exposure to BF may have deleterious effects on the hippocampus and thus behavior. We verified the hypothesis that repeated exposure to BF in a rat model elicits neurochemical and behavioral alterations, the latter of which reflects depression-related symptoms. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.04.012DOI Listing
April 2019
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10 Hz transcranial alternating current stimulation over posterior parietal cortex facilitates tactile temporal order judgment.

Behav Brain Res 2019 Apr 9;368:111899. Epub 2019 Apr 9.

Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan; Department of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, Niigata, Japan.

The temporal order judgment (TOJ) task has been widely used to investigate spatial attentional bias and the sensitivity of temporal discrimination during the processing of bilateral tactile information. Previous studies have shown that TOJ is impaired in patients who are suffering from chronic pain, stroke, and Parkinson's disease. In addition, studies have indicated that the posterior parietal cortex (PPC) is involved in the TOJ task. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111899DOI Listing

New evidence for refinement of anesthetic choice in procedures preceding the forced swimming test and the elevated plus-maze.

Behav Brain Res 2019 Apr 9;368:111897. Epub 2019 Apr 9.

Pharmaceutical Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-900, Brazil; Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-900, Brazil. Electronic address:

Previous studies indicated that some general anesthetics induce long-term antidepressant and/or anxiolytic-like effects. This raises the concern about the use of anesthesia in surgeries that precede psychopharmacological tests, since it may be a potential bias on results depending on the experimental design used. Thus, we evaluated whether general anesthetics used in surgeries preceding psychopharmacological tests would affect rats behavior in tests predictive of antidepressant or anxiolytic-like effects. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.04.011DOI Listing

Administration of protocatechuic acid affects memory and restores hippocampal and cortical serotonin turnover in rat model of oral D-galactose-induced memory impairment.

Behav Brain Res 2019 Apr 9. Epub 2019 Apr 9.

Medical University of Warsaw, Department of Experimental and Clinical Pharmacology, Banacha 1B, 02-097, Warsaw, Poland. Electronic address:

Protocatechuic acid (PCA) is a phenolic compound believed to have neuroprotective and procognitive activity. D-Galactose (D-Gal) is a sugar, which administered to mammals can induce cognitive deficits. The first aim of this study was to confirm the effectiveness of D-Gal administered orally in inducing cognitive impairment in rats and describe how it affects the concentration of neurotransmitters in rats' brain. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.04.010DOI Listing
April 2019
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Effects of a methanol extract of Ficus platyphylla stem bark on a two-way active avoidance task and on body core temperature.

Behav Brain Res 2019 Jul 6;367:215-220. Epub 2019 Apr 6.

Institute of Pharmacology and Toxicology, Faculty of Medicine, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany. Electronic address:

Preparations of Ficus platyphylla are used in Nigeria's folk medicine to manage a variety of diseases, including insomnia, psychoses, depression, epilepsy, pain, and inflammation. In this study, we examined the effects of the standardised methanol extract of F. platyphylla stem bark (FP) on two-way active avoidance learning and body core temperature to complement earlier studies on the neuroleptic potential of this medicinal plant, which is already in common use. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.04.008DOI Listing
July 2019
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Perinatal nicotine exposure impairs learning of a skilled forelimb reaching task in male but not female adult mice.

Behav Brain Res 2019 Jul 6;367:176-180. Epub 2019 Apr 6.

Department of Psychiatry and Interdepartmental Neuroscience Program, Yale University, 34 Park Street, 3rd Floor Research, New Haven, CT, 06508, USA. Electronic address:

Developmental tobacco or nicotine exposure is associated with various adverse outcomes in human and preclinical studies, respectively. For example, perinatal nicotine exposure in mice causes morphologic changes in neurons across sensory and motor cortices and results in impairments in sensory learning. However, the effects of developmental nicotine exposure on motor learning have not been reported. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.04.007DOI Listing

Gentle abdominal stroking ('belly rubbing') of pigs by a human reduces EEG total power and increases EEG frequencies.

Behav Brain Res 2019 Apr 5. Epub 2019 Apr 5.

Department of Medicine, St. Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy, VIC, 3065, Australia.

The neurobiological response to gentle touch remains poorly understood, especially in the context of human-animal interaction. A novel approach allowed recording the pig electroencephalogram (EEG) cranially epidurally and wirelessly during positive interactions with a human. Stroking of the pig's abdomen ('belly rubbing'), applied opportunistically, elicited a distinct behavioral response characterized by lateral recumbency, limb stretching, frequent short-lasting grunts and eye closure. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.04.006DOI Listing
April 2019
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Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion.

Behav Brain Res 2019 Apr 5. Epub 2019 Apr 5.

Department of Neurology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, No. 106. Zhongshan ErRoad, Guangzhou, 510080, Guangdong Province, PR China. Electronic address:

Objectives: Strong evidence has proven that cerebral hypoperfusion is closely related to Parkinson's disease (PD) with cognitive impairment. The aim of this study was to investigate the effect of chronic cerebral hypoperfusion (CCH) on cognitive dysfunction, structural abnormalities of the hippocampus and white matter (WM), and levels of inflammatory cytokines in control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse models.

Methods: In the present study, bilateral common carotid artery stenosis (BCCAS) was performed using microcoils, and the cognitive function and WM lesions (WMLs) after BCCAS were compared between microcoil with 0. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.054DOI Listing
April 2019
2 Reads

Comparison of the effects of nimodipine and deferoxamine on brain injury in rat with subarachnoid hemorrhage.

Behav Brain Res 2019 Jul 3;367:194-200. Epub 2019 Apr 3.

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Subarachnoid hemorrhage (SAH) may lead to brain atrophy and cognitive dysfunction. This study aimed to compare the efficacy of nimodipine and deferoxamine on these sequelae of SAH. A rat model of SAH was established by the double-hemorrhage method. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.04.004DOI Listing
July 2019
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The neural systems of emotion regulation and abnormalities in major depressive disorder.

Behav Brain Res 2019 Jul 2;367:181-188. Epub 2019 Apr 2.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.

Major depressive disorder (MDD) is a mental disorder characterized by aberrant emotion regulation. The capacity for emotion regulation stems from diverse neural circuits including higher level cognitive structures involved in processing contextual information, and lower level limbic structures involved in triggering emotional expression. Cognitive theories of depression posit that the MDD-specific abnormalities in emotional control derive itself from dysfunctional cognitive processes including biased attention, rumination, and altered information processing and memory. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328193014
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http://dx.doi.org/10.1016/j.bbr.2019.04.002DOI Listing
July 2019
6 Reads

Expression of aggressiveness modulates mesencephalic c-fos activation during a social interaction test in Japanese quail (Coturnix japonica).

Behav Brain Res 2019 Jul 3;367:221-229. Epub 2019 Apr 3.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Investigaciones Biológicas y Tecnológicas (IIByT), Córdoba, Argentina; Universidad Nacional de Córdoba, Facultad de Ciencias Exactas, Físicas y Naturales, Instituto de Ciencia y Tecnología de los Alimentos (ICTA), Córdoba, Argentina; Universidad Nacional de Córdoba, Facultad de Ciencias Exactas, Físicas y Naturales, Cátedra de Química Biológica, Av. Vélez Sársfield 1611 (5000), Córdoba, Argentina. Electronic address:

It is well known that during a social conflict, interactions are dependent on the animal's propensity to behave aggressively as well as the behavior of the opponent. However, discriminating between these two confounding factors was difficult. Recently, a Social Interaction (SI) test using photocastrated males as non-aggressive stimuli was proposed as a useful tool to evaluate aggressiveness. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328183136
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http://dx.doi.org/10.1016/j.bbr.2019.04.003DOI Listing
July 2019
4 Reads

MESENCHYMAL STEM CELL THERAPY IMPROVES SPATIAL MEMORY AND HIPPOCAMPAL STRUCTURE IN AGING RATS.

Behav Brain Res 2019 Apr 2. Epub 2019 Apr 2.

INIBIOLP-Pathology B, School of Medicine, National University of La Plata, Argentina; Department of Histology and of Embryology B, School of Medicine, National University of La Plata, Argentina. Electronic address:

There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine in the brain as they have shown neurogenic and immunomodulatory activities. We assessed the effect of intracerebroventricular (icv) administration of human bone marrow-derived MSCs (hBM-MSCs) on spatial memory and hippocampal morphology of senile (27 months) female rats, using 3-months-old counterparts as young controls. Half of the animals were injected in the lateral ventricles (LV) with a suspension containing 5 × 10hBM-MSCs in 8 µl per side. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.04.001DOI Listing
April 2019
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Restoring emotional stability: Cortisol effects on the neural network of cognitive emotion regulation.

Behav Brain Res 2019 Apr 1. Epub 2019 Apr 1.

Institute of Cognitive Neuroscience, Department of Cognitive Psychology, Ruhr University Bochum, Germany.

Effective emotion regulation in stressful contexts is a key feature of mental health. Acute stress, however, impairs prefrontal top-down control, probably leading to a decline of emotion regulatory capacities. By contrast, the delayed cortisol increase in response to a stressor or after a pharmacological manipulation has been linked to mood-protecting effects and emotion regulation success. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.049DOI Listing
April 2019
1 Read

Theta and alpha band oscillations during value-directed strategic processing.

Behav Brain Res 2019 Jul 31;367:210-214. Epub 2019 Mar 31.

Neuroscience Program, University of Illinois at Urbana-Champaign, Champaign, IL, United States; Department of Speech and Hearing Science, University of Illinois at Urbana-Champaign, Champaign, IL, United States. Electronic address:

Strategic processing allows for value-based preferential encoding of information. Event-related spectral perturbations can provide insights into neural processes linked to the different aspects of strategic processing. This study examined theta and alpha band power differences linked to processing of high- versus low-value information. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.052DOI Listing
July 2019
4 Reads

The role of anti-inflammatory cytokines in memory processing in a healthy brain.

Behav Brain Res 2019 Jul 31;367:111-116. Epub 2019 Mar 31.

Institute of Theoretical and Experimental Biophysics, RAS, Pushchino, Russia; Pushchino State Institute of Natural Sciences, Pushchino, Russia.

The purpose of the work was to study the role of anti-inflammatory cytokines in memory processing in a healthy brain. Wistar rats were trained to perform a task with positive (food) reinforcement; and then the task performance was tested after intraventricular injection of IL-10 or TGF-β1. A microinjection into the brain of either of the two cytokines did not affect the performance of the task and did not have an anti-amnesic effect when the retrieval was deteriorated with scopolamine. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328183162
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http://dx.doi.org/10.1016/j.bbr.2019.03.053DOI Listing
July 2019
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Downregulation of sonic hedgehog signaling in the hippocampus leads to neuronal apoptosis in high-fat diet-fed mice.

Behav Brain Res 2019 Jul 30;367:91-100. Epub 2019 Mar 30.

Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Sciences, Jiangsu Normal University, Xuzhou, China. Electronic address:

Background/aims: Obesity induces hippocampal neuronal apoptosis and leads to cognitive function deficits. Sonic hedgehog (SHH) signaling is crucial during nervous system development and is neuroprotective in many neurologic diseases. This study assessed the role of SHH signaling in the cognitive deficits in high-fat diet (HFD)-induced obese mice. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.055DOI Listing
July 2019
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Ventromedial prefrontal cortex is involved in preference and hedonic evaluation of tastes.

Behav Brain Res 2019 Jul 30;367:149-157. Epub 2019 Mar 30.

Institute of Physiology, Medical School, Pécs University, Pécs, Hungary; Neuroscience Center, Pécs University, Pécs, Hungary; Molecular Neuroendocrinology Research Group, Szentágothai Research Center, Pécs University, Pécs, Hungary. Electronic address:

The ventromedial prefrontal cortex (vmPFC) of rats has reciprocal connections with the gustatory and the hedonic impact coding structures. The main goal of the present study was to investigate the involvement of local neurons of vmPFC and their catecholaminergic innervations in taste preference and taste reactivity test. Therefore, kainate or 6-hydroxydopamine (6-OHDA) lesions were performed in the vmPFC by iontophoretic method. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.051DOI Listing
July 2019
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The Adapted Autobiographical Interview: A Systematic Review and Proposal for Conduct and Reporting.

Behav Brain Res 2019 Mar 29. Epub 2019 Mar 29.

Universidad de la República, Uruguay.

The adapted Autobiographical Interview (AI) is one of the most commonly used and widely cited measures of prospection in adult humans. The use of this instrument requires investigators to make many decisions that can influence the outcomes of studies. Here, we performed a systematic review of studies utilizing the adapted AI. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.050DOI Listing

Repeated treatments with the D dopamine receptor agonist SKF-38393 modulate cell viability via sustained ERK-Bad-Bax activation in dopaminergic neuronal cells.

Behav Brain Res 2019 Jul 28;367:166-175. Epub 2019 Mar 28.

Department of Pharmacy and Research Center for Bioresource and Health, College of Pharmacy, Chungbuk National University, 194-21, Osongsaengmyeong 1-ro, Osong, Heungduk-gu, Cheongju 28160, Republic of Korea. Electronic address:

The D dopamine receptor agonist, SKF-38393, induces cytotoxicity in striatal dopaminergic neurons via an extracellular signal-regulated kinase (ERK) signaling cascade. However, the underlying mechanism remains unclear. We hypothesized that repeated activation of dopaminergic receptors by agonists could lead to neuronal cell death. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.035DOI Listing
July 2019
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Enriched experience during pregnancy and lactation protects against motor impairments induced by neonatal hypoxia-ischemia.

Behav Brain Res 2019 Jul 28;367:189-193. Epub 2019 Mar 28.

Post-graduation Program of Physiology, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Department of Biochemistry, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Neonatal hypoxia-ischemia (HI) is responsible for movement disorders in preterm infants. Non-pharmacological strategies, such as environmental enrichment (EE) during adulthood, have shown positive effects on promoting sensorimotor recovery after HI. However, little is known about the effects of perinatal EE on sensorimotor function following HI. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.048DOI Listing
July 2019
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Estrogen receptors α and β in the central amygdala and the ventromedial nucleus of the hypothalamus: Sociosexual behaviors, fear and arousal in female rats during emotionally challenging events.

Behav Brain Res 2019 Jul 27;367:128-142. Epub 2019 Mar 27.

Department of Psychology, University of Tromsø, Huginbakken 32, 9037, Tromsø, Norway.

Estrogens receptors (ER) are involved in several sociosexual behaviors and fear responses. In particular, the ERα is important for sexual behaviors, whereas ERβ modulates anxiolytic responses. Using shRNA directed either against the ERα or the ERβ RNAs (or containing luciferase control) encoded within an adeno-associated viral vector, we silenced these receptors in the ventromedial nucleus of the hypothalamus (VMN) and the central amygdala (CeA). Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.045DOI Listing

Effect of acute exposure to hypobaric hypoxia on learning and memory in adult Sprague-Dawley rats.

Behav Brain Res 2019 Jul 27;367:82-90. Epub 2019 Mar 27.

School of Medicine, Xizang Minzu University, Wenhui East Road, Xianyang, 712082, China.

The present study aimed to observe the effects of acute exposure to hypobaric hypoxia on learning and memory in adult Sprague-Dawley (SD) rats as well as the changes in N-methyl-D-aspartate receptor (NMDAR) subunits. Learning and memory abilities were evaluated with Morris water maze following simulated hypoxia at 5000 m or 7000 m for 2, 4 or 6 days. The number of red blood cells, the level of hemoglobin, oxidative stress markers, the extent of neuronal damage in the hippocampal CA1, and the expression of NMDAR subunits were all measured. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.047DOI Listing
July 2019
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Kinetic deterioration of short memory in rat with acute hepatic encephalopathy: Involvement of astroglial and neuronal dysfunctions.

Behav Brain Res 2019 Jul 27;367:201-209. Epub 2019 Mar 27.

Neuroscience, Pharmacology and Environment Unit (ENPE), faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech, Morocco. Electronic address:

Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome resulting from acute or chronic hepatic impairments. The clinical features of HE include attention as well as a mild cognitive deficits associated with impaired attentional and executive networks in patients as well as in animal models of HE. The underlining pathomechanism of memory impairment in HE patients is still not fully understood; however, it may involve a possible gliopathy as well as neuropathy. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.046DOI Listing
July 2019
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Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders.

Behav Brain Res 2019 Jul 27;367:101-110. Epub 2019 Mar 27.

School of Pharmacy, Southwest University, Chongqing, China; Ural Federal University, Ekaterinburg, Russia; Institute of Translational Biomedicine (ITBM), St. Petersburg State University, St. Petersburg, Russia; Granov Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA; ZENEREI Research Center, Slidell, LA, USA; Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia. Electronic address:

Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models as well. While rodent studies of ARBs continue to dominate the field, mounting evidence suggests that zebrafish (Danio rerio) also display ARB-like phenotypes and may therefore be a novel model organism for ARB research. In addition to clear practical research advantages as a model species, zebrafish share high genetic and physiological homology to humans and rodents, including multiple ARB-related genes and robust behaviors relevant to ARB. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.044DOI Listing

That does not sound right: Sounds affect visual ERPs during a piano sight-reading task.

Behav Brain Res 2019 Jul 25;367:1-9. Epub 2019 Mar 25.

CTNSC - Center for Translational Neurophysiology for Speech and Communication, IIT - Istituto Italiano di Tecnologia, Ferrara, Italy; Dipartimento di Scienze Biomediche e Chirurgico Specialistiche, University of Ferrara, Ferrara, Italy.

Prolonged musical training induces important audio-visuo-motor plastic processes. However, little is known about how the musicians' brain resolves multimodal conflicts while preparing for musical action. We run an electroencephalographic (EEG) investigation on how visual processing for action (score reading) is affected by preceding task-irrelevant piano sounds, usually associated to the same or to a different action. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.037DOI Listing
July 2019
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Resveratrol synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson disease in mice.

Behav Brain Res 2019 Jul 25;367:10-18. Epub 2019 Mar 25.

State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China. Electronic address:

L-DOPA (L-3,4-dihydroxyphenylalanine) relieves symptoms of Parkinson disease (PD), but long-term use can cause serious side effects. Resveratrol (3,5,4'-trihydroxy-trans-stilbene, RV), a polyphenolic compound derived from grapes and red wine that has antioxidant activity, has been shown to have neuroprotective effects. RV was investigated to enhance the therapeutic effect of L-DOPA in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse model of Parkinson disease. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.043DOI Listing
July 2019
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Anxiolytic-like effect of chalcone N-{(4'-[(E)-3-(4-fluorophenyl)-1-(phenyl) prop-2-en-1-one]} acetamide on adult zebrafish (Danio rerio): involvement of the GABAergic system.

Behav Brain Res 2019 Mar 25. Epub 2019 Mar 25.

State University of Ceará, Science and Technology Center (CCT), Itaperi Campus, Laboratory of Natural Products Chemistry - LQPN-S, CEP 60741-000, Fortaleza, Ceará, Brazil. Electronic address:

Benzodiazepines are the standard drugs for the treatment of anxiety, but their undesirable side effects make it necessary to develop new anxiolytic drugs. The objective of this study was to evaluate the possible anxiolytic-simile effect of synthetic chalcone N-{(4'-[(E)-3-(4-fluorophenyl)-1-(phenyl) prop-2-en-1-one]} acetamide (PAAPFBA) on adult zebrafish (Danio rerio). PAAPFBA was synthesized with an 88. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.040DOI Listing
March 2019
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Have I been here before? Complex interactions of age and test experience modulate the results of behavioural tests.

Behav Brain Res 2019 Jul 25;367:143-148. Epub 2019 Mar 25.

Department of Behavioural Biology, University of Münster, Germany; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Germany.

Recently, a discussion about the reproducibility of results from behavioural phenotyping experiments has emerged. A huge emphasis has therefore been put on the identification of those factors that might limit the reproducibility of behavioural data. As a comprehensive phenotypic characterisation can involve testing of the same animal repeatedly over a specific time period, the aim of the present study was to systematically investigate effects of two potentially confounding variables, age of the animals and test experience. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.042DOI Listing

Impaired amygdala-based learning and decreased anxiety in a murine model of pseudohypoparathyroidism type 1A.

Behav Brain Res 2019 Jul 25;367:53-58. Epub 2019 Mar 25.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Pseudohypoparathyroidism type 1A (PHP1A) is a genetic disorder caused by maternally inherited mutations in the gene Gnas. PHP1A is characterized by multiple hormone impairment, early onset obesity and cognitive impairment. Animal models of PHP1A are needed to investigate the mechanism of cognitive impairment. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476654PMC
July 2019
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Sustained overexpression of neuropeptide S in the amygdala reduces anxiety-like behavior in rats.

Behav Brain Res 2019 Jul 23;367:28-34. Epub 2019 Mar 23.

Laboratory of Neural Plasticity, Institute of Neuroscience, University of Copenhagen, Copenhagen, Denmark.

Neuropeptide S (NPS) has shown anxiolytic-like effects in rodents after acute administration, but its long-term effects remain unknown. Gene therapy enables the targeted delivery of DNA to cell nuclei, and recombinant adeno-associated viral (rAAV) vectors have been identified as suitable tools for stable overexpression. Thus, to explore the effects of long-term expression of NPS, the present study examined anxiety- and depressive-like effects after rAAV-mediated NPS overexpression in the rat amygdala. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.039DOI Listing
July 2019
3.028 Impact Factor

Response control correlates of anomalous basal ganglia morphology in boys, but not girls, with attention-deficit/hyperactivity disorder.

Behav Brain Res 2019 Jul 23;367:117-127. Epub 2019 Mar 23.

The Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD, USA. Electronic address:

Anomalous basal ganglia morphology may contribute to deficient motor response control in children with attention-deficit/hyperactivity disorder (ADHD). This study expands upon recent evidence of sex differences in subcortical morphology and motor response control deficits among children with ADHD to examine basal ganglia volume and shape in relation to motor response control. Participants included 8-12 year-old children with ADHD (n = 52, 21 girls) and typically developing (TD) controls (n = 45, 19 girls). Read More

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http://dx.doi.org/10.1016/j.bbr.2019.03.036DOI Listing
July 2019
1 Read