12,478 results match your criteria Behavioural Brain Research [Journal]


Increased repetitive self-grooming occurs in Pax2 mutant mice generated using CRISPR/Cas9.

Behav Brain Res 2020 Jul 9:112803. Epub 2020 Jul 9.

Nephrology Division, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, Taiyuan, China. Electronic address:

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction and communication, and repetitive or restricted interest and behaviors. However, the specific pathogenesis of ASD is still unclear. It has been widely accepted that genetic and environmental risk factors are associated with the pathogenesis of ASD. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112803DOI Listing

Enhancement of the rewarding effects of 3,4-methylenedioxymethamphetamine in orexin knockout mice.

Behav Brain Res 2020 Jul 9:112802. Epub 2020 Jul 9.

Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, 142-8501, Japan; Institute of Drug Addiction Research, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, 142-8501, Japan. Electronic address:

Orexinergic neurons, which are closely associated with narcolepsy, regulate arousal and reward circuits through the activation of monoaminergic neurons. Psychostimulants as well as 5-HT-related compounds have potential in the treatment of human narcolepsy. Previous studies have demonstrated that orexin receptor antagonists as well as orexin deficiencies affect the pharmacological effects of psychostimulants. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112802DOI Listing

Selective sub-nucleus effects of intra-amygdala oxytocin on fear extinction.

Behav Brain Res 2020 Jul 9:112798. Epub 2020 Jul 9.

Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.

There is growing evidence that the neuropeptide oxytocin (OT) modulates fear and extinction in humans and rodents through actions in corticolimbic circuits including the central amygdala (CeA). Prior studies have, however, been limited to subjects that exhibit intact basal extinction, rather than extinction-impaired populations that could potentially therapeutically benefit from viable OT-targeting treatments. Here, we assessed the effects of pre-extinction training infusion of OT into the CeA, or basolateral amygdala (BLA), on extinction in an inbred mouse strain (S1) model of impaired extinction. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112798DOI Listing

Peripubertal stress following maternal immune activation sex-dependently alters depression-like behaviors in offspring.

Behav Brain Res 2020 Jul 9:112800. Epub 2020 Jul 9.

Salari Institute of Cognitive and Behavioral Disorders (SICBD), Alborz, Karaj, Iran. Electronic address:

There is an increasing evidence that maternal immune activation can render the offspring more vulnerable to the impacts of peripubertal stress on behavioral abnormalities in adulthood. The aim of this study was to investigate the combined effects of maternal immune activation and peripubertal stress on depression-related behaviors in male and female offspring. Pregnant mice were treated with lipopolysaccharides (LPS) or vehicle, and then offspring were subjected to stressful conditions or left unstressed during peripubertal period. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112800DOI Listing

Effects of stimulating the supplementary motor area with a transcranial alternating current for bimanual movement performance.

Behav Brain Res 2020 Jul 8:112801. Epub 2020 Jul 8.

Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Japan.

Transcranial alternating current stimulation (tACS) can regulate the frequency of neuronal activity in the cerebral cortex. Beta (β) activity in the supplementary motor area (SMA) is involved in motor planning and maintenance while gamma (γ) activity is involved in updating motor plans. We investigated the effect of tACS in the β- and γ-bands (β-tACS and γ- tACS) applied to the SMA on bimanual movement performance. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112801DOI Listing

Individual expression of conditioned safety but not of conditioned relief is correlated with contextual fear.

Behav Brain Res 2020 Jul 7;393:112799. Epub 2020 Jul 7.

Institute for Pharmacology and Toxicology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany; Center of Behavioral Brain Sciences, Otto-von-Guericke University Magdeburg, Magdeburg, Germany. Electronic address:

Stimuli that are either presented directly after or explicitly unpaired to an aversive event can be associated with the relief or absence of the aversive event. Such stimuli then become conditioned stimuli (CS) for relief or safety, respectively, and are able to induce appetitive-like behavioral responses, e.g. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112799DOI Listing

The anxiolytic effect of a promising quinoline containing selenium with the contribution of the serotonergic and GABAergic pathways: Modulation of parameters associated with anxiety in mice.

Behav Brain Res 2020 Jul 7;393:112797. Epub 2020 Jul 7.

Programa de Pós-graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica (LaFarBio), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, RS, Brazil. Electronic address:

Recently, we demonstrated the promising anxiolytic action of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) in mice. For this reason, the objective of this study was to expand our previous findings by investigating the contribution of serotoninergic and GABAergic systems to the anxiolytic action of this compound. Pretreatment with different serotoninergic antagonists (pindolol, WAY100635 and ketanserin) blocked the anxiolytic effect caused by 4-PSQ (50 mg/kg, per oral) in the elevated plus maze (EPM) test. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112797DOI Listing

Long-term exposure to ephedrine leads to neurotoxicity and neurobehavioral disorders accompanied by up-regulation of CRF in prefrontal cortex and hippocampus in rhesus macaques.

Behav Brain Res 2020 Jul 4:112796. Epub 2020 Jul 4.

Department of Radiology, The First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou, 515041, Guangdong, China; Shantou University Medical College, No. 22 Xinling Road, Shantou, 515041, Guangdong, China; Guangdong Key Laboratory of Medical Molecular Imaging, No. 57 Changping Road, Shantou, 515041, Guangdong, China. Electronic address:

Drug addiction continues to threaten the health and welfare of people worldwide, and ephedrine abuse is a serious drug problem in many areas of the world. Ephedrine toxicity is thought to induce behavioral effects primarily through actions on the central nervous system. The corticotropin-releasing factor (CRF) system plays an important role in regulating behavioral effects induced by addictive drugs, but whether CRF is related to ephedrine toxicity remains unclear. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112796DOI Listing

Allocentric coordinate spatial representations are impaired in aMCI and Alzheimer's disease patients.

Behav Brain Res 2020 Jun 30;393:112793. Epub 2020 Jun 30.

Laboratory of Cognitive Science and Immersive Virtual Reality, CS-IVR, Department of Psychology, University of Campania L. Vanvitelli, Caserta, Italy.

Research has reported deficits in egocentric (subject-to-object) and mainly allocentric (object-to-object) spatial representations in the early stages of the Alzheimer's disease (eAD). To identify early cognitive signs of neurodegenerative conversion, several studies have shown alterations in both reference frames, especially the allocentric ones in amnestic-Mild Cognitive Impairment (aMCI) and eAD patients. However, egocentric and allocentric spatial frames of reference are intrinsically connected with coordinate (metric/variant) and categorical (non-metric/invariant) spatial relations. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112793DOI Listing

Large nest building and high marble-burying: Two compulsive-like phenotypes expressed by deer mice (Peromyscus maniculatus bairdii) and their unique response to serotoninergic and dopamine modulating intervention.

Behav Brain Res 2020 Jun 30;393:112794. Epub 2020 Jun 30.

Center of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North West-University, Potchefstroom, South Africa. Electronic address:

This study aimed to further dissect the deer mouse (Peromyscus maniculatus bairdii) model of compulsive-like behavior with respect to two persistent-like behavioral phenotypes viz. large nest building (LNB) and high marble-burying (HMB), which may be relevant to understanding the neurobiology of different symptom dimensions in obsessive-compulsive and related disorders. Since LNB is sensitive to chronic, high dose escitalopram intervention but HMB is not, we assessed whether the two behaviors could be further distinguished based on their response to 4 weeks of uninterrupted serotoninergic intervention (i. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112794DOI Listing
June 2020
3.028 Impact Factor

TRPM4 inhibition improves spatial memory impairment and hippocampal long-term potentiation deficit in chronic cerebral hypoperfused rats.

Behav Brain Res 2020 Jun 30:112781. Epub 2020 Jun 30.

Centre for Drug Research, Universiti Sains Malaysia, 11800 Penang, Malaysia. Electronic address:

Chronic cerebral hypoperfusion (CCH) been well characterized as a common pathological status contributing to neurodegenerative diseases such as Alzheimer's disease and vascular dementia. CCH is an important factor that leads to cognitive impairment, but the underlying neurobiological mechanism is poorly understood and no effective treatment is available. Recently, transient receptor potential melastatin 4 (TRPM4) cation channel has been identified as an important molecular element in focal cerebral ischemia. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112781DOI Listing

Amyloid-beta (1-42) lesion of CA1 rat dorsal hippocampus reduces contextual fear memory and increases expression of microglial genes regulating neuroinflammation.

Behav Brain Res 2020 Jun 30;393:112795. Epub 2020 Jun 30.

Discipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa.

Emerging evidence indicates that the pathogenesis of Alzheimer's disease (AD) is not confined to neuronal disruptions but robustly communicates with the brain's immune system. Genome-wide analysis suggests that several genes, which increase the risk for AD, encode for factors that regulate the glial clearance of misfolded proteins and the inflammatory reaction. This study reappraises the amyloid hypothesis by focusing on the impact of neuroinflammation in a beta-amyloid model of AD, how this possibly exacerbates the disease's progression, and the correlation between genes regulating neuroinflammation (CD33 and TREM2) with post-training recall. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112795DOI Listing

The relationship between loneliness and working-memory-related frontoparietal network connectivity in people with major depressive disorder.

Behav Brain Res 2020 Jun 29:112776. Epub 2020 Jun 29.

State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong; Laboratory of Neuropsychology, The University of Hong Kong, Hong Kong. Electronic address:

Loneliness affects up to 40% of middle-aged and older adults, and is closely associated with major depressive disorder (MDD). However, the relationship between loneliness and neural network functioning during executive cognitive processes, such as working memory, in MDD is still unclear. To address this gap, our study recruited 21 medicated MDD patients (mean age = 52. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112776DOI Listing

Oxytocin in the anterior cingulate cortex is involved in helping behaviour.

Behav Brain Res 2020 Jun 27;393:112790. Epub 2020 Jun 27.

Department of Psychological Sciences, Kwansei Gakuin University, 1-1-155, Uegahara, Nishinomiya, Hyogo, 662-8501, Japan. Electronic address:

Empathy toward the distress of others is thought to motivate helping behaviour, in the form of voluntary action to eliminate that distress. Neuropeptide oxytocin is associated with various social cognitive abilities, including empathy and prosocial behaviour. The anterior cingulate cortex is known to be one of the brain regions underlying empathy, and one in which oxytocin receptors are expressed. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112790DOI Listing

Dysregulation of protein degradation in the hippocampus is associated with impaired spatial memory during the development of obesity.

Behav Brain Res 2020 Jun 27;393:112787. Epub 2020 Jun 27.

Department of Animal and Poultry Science, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA. Electronic address:

Studies have shown that long-term exposure to high fat and other obesogenic diets results in insulin resistance and altered blood brain barrier permeability, dysregulation of intracellular signaling mechanisms, changes in DNA methylation levels and gene expression, and increased oxidative stress and neuroinflammation in the hippocampus, all of which are associated with impaired spatial memory. The ubiquitin-proteasome system controls the majority of protein degradation in cells and is a critical regulator of synaptic plasticity and memory formation. Yet, whether protein degradation in the hippocampus becomes dysregulated following weight gain and is associated with obesity-induced memory impairments is unknown. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112787DOI Listing

Prophylactic effect of physical exercise on Aβ-induced depressive-like behavior and gut dysfunction in mice.

Behav Brain Res 2020 Jun 26;393:112791. Epub 2020 Jun 26.

Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina 88040-900, Brazil. Electronic address:

Alzheimer's disease (AD) is a prevalent neurodegenerative disease that is highly comorbid with depression. Gut dysfunction has been proposed as a possible risk factor for both clinical conditions. In the present study, we investigated the ability of treadmill exercise for 4 weeks (5 days/week, 40 min/day) to counteract amyloid β peptide (Aβ)-induced depressive-like behavior, alterations in morphological parameters of the duodenum, and the abundance of Firmicutes and Bacteroidetes phyla. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112791DOI Listing

Circadian disruption impairs fear extinction and memory of conditioned safety in mice.

Behav Brain Res 2020 Jun 26;393:112788. Epub 2020 Jun 26.

Department of Pharmacology and Therapeutics, The University of Melbourne, VIC, Australia; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, VIC, Australia. Electronic address:

Animal models of fear conditioning and fear inhibition are frequently employed in the study of associative learning and commonly derive important human implications. Animal and human studies have demonstrated fear processing abilities are moderated by circadian rhythms, however, the influence of circadian disruption on fear inhibition is not well understood. Here, we examined the effects of circadian disruption on fear inhibition processes (i. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112788DOI Listing

Subjective reward value of visual sexual stimuli is coded in human striatum and orbitofrontal cortex.

Behav Brain Res 2020 Jun 27;393:112792. Epub 2020 Jun 27.

Department of Psychotherapy and Systems Neuroscience, Justus Liebig University, 35394 Giessen, Germany; Bender Institute for Neuroimaging (BION), Justus Liebig University, 35394 Giessen, Germany; Center of Mind, Brain and Behavior, Universities of Marburg and Giessen, 35032 Marburg, Germany.

Human neuroimaging research suggests the existence of one core network for the subjective valuation of rewards, including the striatum and orbitofrontal cortex. However, there is little research on the neural representation of subjective reward values of visual sexual stimuli (VSS) and on the role of these subjective valuations in the development of related addictive behaviors. Here, we investigate how neural reactivity to VSS is connected to individual preference using functional magnetic resonance imaging (fMRI). Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112792DOI Listing

Vinpocetine facilitates the anti-amnesic activity of estrogen-receptor alpha agonist in bilateral ovariectomy-challenged animals.

Behav Brain Res 2020 Jun 25;393:112789. Epub 2020 Jun 25.

Division of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India. Electronic address:

The fluctuation in plasma estrogen level influences the cognitive function in the females. The specific estrogen receptor alpha (ERα) agonist, (4,4',4″-(4-propyl-[1 H] pyrazole-1,3,5-triyl) tris phenol (PPT), is reported to exhibit therapeutic activity similar to that of estrogen replacement therapy. However, the former can also exert cyclic adenosine monophosphate (cAMP)-dependent carcinogenic activity in the uterus of the ovariectomized animals. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112789DOI Listing

Modulation of brain stimulation reward and locomotor activity by ionotropic glutamate receptors of the tail of the ventral tegmental area.

Behav Brain Res 2020 Jun 25;393:112785. Epub 2020 Jun 25.

Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

The rostromedial tegmental nucleus also referred to as the tail of the ventral tegmental area (tVTA) contains a cluster of gamma-aminobutyric acid (GABA)ergic neurons that receive dense glutamatergic afferents from the lateral habenula (LHb), and project to dopamine (DA) neurons of the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). In light of previous evidence implicating glutamate transmission in the regulation of midbrain DA neuronal activity, we first assessed the impact of intra-tVTA microinjection of NBQX (0.8 nmol/side) and PPPA (0. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112785DOI Listing
June 2020
3.028 Impact Factor

Structural brain changes in Ser129-phosphorylated alpha-synuclein rats based on voxel-based morphometry.

Behav Brain Res 2020 Jun 24;393:112786. Epub 2020 Jun 24.

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Department of Neurology, China. Electronic address:

Parkinson's disease has become one of the most common neurodegenerative diseases. Pathological changes typically manifest following dopaminergic neuron loss in the substantia nigra and abnormal alpha-synuclein (α-syn) aggregation in the neurons. α-Syn is the major component of Lewy bodies. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112786DOI Listing

Corrigendum to "Monoamine oxidase A genotype and methylation moderate the association of maltreatment and aggressive behaviour" [Behav. Brain Res. 382 (2020) 112476].

Behav Brain Res 2020 Jun 23;393:112721. Epub 2020 Jun 23.

Department of Neuroscience, Uppsala University, Uppsala Biomedical Center, Husargatan 3, 751 24, Uppsala, Sweden; Centre for Clinical Research, Uppsala University, Västmanland County Council, Västmanlands Sjukhus Västerås, 721 89, Västerås, Sweden.

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http://dx.doi.org/10.1016/j.bbr.2020.112721DOI Listing

Short-term exposure to dietary cholesterol is associated with downregulation of interleukin-15, reduced thigmotaxis and memory impairment in mice.

Behav Brain Res 2020 Jun 22;393:112779. Epub 2020 Jun 22.

Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, Loma Linda, CA, USA. Electronic address:

Alzheimer's disease (AD) is a neurodegenerative condition associated with loss of memory function, depression and anxiety. The etiology of AD is poorly understood, but both cholesterol dyshomeostasis and dysregulation of the immune system are contributing factors. Current evidence is consistent with a detrimental effect of excess cholesterol on neuroinflammation, both in mouse models of memory loss and in dementia in humans. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112779DOI Listing

Sociability and extinction of conditioned social fear is affected in neuropeptide S receptor-deficient mice.

Behav Brain Res 2020 Jun 22;393:112782. Epub 2020 Jun 22.

Institute for Pharmacology and Toxicology, Otto von Guericke University Magdeburg, Leipziger Straße 44, D-39120 Magdeburg, Germany; Center for Behavioral Brain Sciences, Otto von Guericke University Magdeburg, Leipziger Straße 44, D-39120 Magdeburg, Germany. Electronic address:

Being cautious of unfamiliar conspecifics is adaptive because sick or aggressive conspecifics may jeopardize survival and well-being. However, prolonged or excessive caution, i.e. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112782DOI Listing

A reinforcement-learning model of active avoidance behavior: Differences between Sprague Dawley and Wistar-Kyoto rats.

Behav Brain Res 2020 Jun 22;393:112784. Epub 2020 Jun 22.

Rutgers School of Graduate Studies, Rutgers Biomedical Health Sciences, 185 South Orange Avenue, Newark, NJ, 07103, USA; VA New Jersey Health Care System, Department of Veterans Affairs, 385 Tremont Avenue, East Orange, NJ, 07018, USA; Department of Pharmacology, Physiology, and Neuroscience, Rutgers Biomedical Health Sciences, 185 South Orange Avenue, Newark, NJ, 07103, USA.

Avoidance behavior is a typically adaptive response performed by an organism to avert harmful situations. Individuals differ remarkably in their tendency to acquire and perform new avoidance behaviors, as seen in anxiety disorders where avoidance becomes pervasive and inappropriate. In rodent models of avoidance, the inbred Wistar-Kyoto (WKY) rat demonstrates increased learning and expression of avoidance compared to the outbred Sprague Dawley (SD) rat. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112784DOI Listing

Effect of 5-HT receptor agonist and antagonist on chronic unpredictable stress (CUS) - Mediated anxiety and depression in adolescent Wistar albino rat: Implicating serotonin and mitochondrial ETC-I function in serotonergic neurotransmission.

Behav Brain Res 2020 Jun 21;393:112780. Epub 2020 Jun 21.

Department of Biochemistry, North Eastern Hill University, Shillong, 793 022, Meghalaya, India.

Anxiety and depression are among the major neuropsychiatric disorders worldwide, and yet the etiologies of these disorders remain unclear to date. Chronic unpredictable stress (CUS) procedure mimics several behavioral characteristics such as anxiety and depression in rodents. Using this animal model, we have attempted to understand the serotonergic system in the hippocampus and prefrontal cortex, while using the 5-HTR agonist and antagonist in evaluating 5-HT receptor neurotransmission. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112780DOI Listing

Cognitive impairments in adult mice with RIP140 overexpression in neural stem cells.

Behav Brain Res 2020 Jun 21;393:112777. Epub 2020 Jun 21.

Department of Pediatric, Peking University People's Hospital, Beijing 100044, China. Electronic address:

Receptor-interacting protein 140 (RIP140) is a transcription co-regulator of several transcription factors and a signal transduction regulator. RIP140 was recently implicated in the regulation of cognitive functions. The gene that encodes RIP140 is located on chromosome 21. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112777DOI Listing

The nicotinic α7 receptor agonist GTS-21 but not the nicotinic α4β2 receptor agonist ABT-418 attenuate the disrupting effects of anesthetic ketamine on recognition memory in rats.

Behav Brain Res 2020 Jun 21;393:112778. Epub 2020 Jun 21.

Department of Pharmacology, Faculty of Health Sciences, School of Medicine, University of Thessaly, Panepistimiou 3, Biopolis, 41500 Larissa, Greece. Electronic address:

Several lines of evidence indicate that anesthetic doses of the non-competitive N-methyl-D-aspartate receptor antagonist ketamine disrupt memory functions in rodents. The mechanism by which anesthetic ketamine produces its adverse behavioural effects is not yet clarified. The implication of nicotinic acetylcholine receptor as a potential site of action of anesthetic ketamine adverse effects on memory is proposed. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112778DOI Listing

Validation of behavioral phenotypes in the BACHD rat model.

Behav Brain Res 2020 Jun 20;393:112783. Epub 2020 Jun 20.

Institute of Medical Genetics and Applied Genomics, University of Tübingen, Calwerstrasse7, 72076, Tübingen, Germany; Centre for Rare Diseases, University of Tübingen, Calwerstrasse7, 72076, Tübingen, Germany; Department of Human Genetics, Ruhr University Bochum, Universitätsstraße 150, 44801, Bochum, Germany. Electronic address:

Huntington disease (HD) is a neurodegenerative disorder caused by a polyglutamine expansion in the HTT gene. Various HD animal models have been generated to mimic the motor, cognitive and neuropsychiatric disturbances that affect HD patients. Reproducing disease phenotypes within these models is essential to identify reliable readouts for therapy studies. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112783DOI Listing

Differential immediate early gene activity revealed by playback of male and female incomplete chick-a-dee calls.

Behav Brain Res 2020 Jun 18;393:112775. Epub 2020 Jun 18.

Department of Psychology, University of Alberta, Canada; Neuroscience and Mental Health Institute, University of Alberta, Canada. Electronic address:

In both humans and animals, biological differences between males and females has long been a topic of research. In songbirds, sexual dimorphisms can be seen in many species' plumage and heard in some species' songs. However, not all songbirds have such overt phenotypic sexual differences, leading to the question: are all vocalizations dimorphic? One of the most used and versatile vocalizations of the black-capped chickadee (Poecile atricapillus) is their namesake chick-a-dee call, that is produced by both sexes. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112775DOI Listing

Combined effects of caloric restriction and fish oil attenuated anti-depressant and anxiolytic-like effects of fish oil: association with hippocampal BDNF concentrations.

Behav Brain Res 2020 Jun 16;393:112770. Epub 2020 Jun 16.

Post Graduate Program in Nutrition, Department of Nutrition, Health Sciences Centre, Universidade Federal de Santa Catarina (UFSC), Brazil. Electronic address:

Omega-3-enriched fish oil (FO) and caloric restriction (CR) are nutritional therapeutic approaches that exert an important impact on brain function, behavior, memory, and neuroprotection. Here, we investigate the synergic effects of both therapeutic approaches combined (CR + FO) on behavior (memory, anxiety-like behavior, antidepressant-like behavior), as well as its association with hippocampal brain-derived neurotrophic factor (BDNF) concentrations. Adult male Wistar rats were divided into four dietary groups: Control group (C) - chow ad libitum; CR group - 30 % CR, considering C group food intake; FO group - FO-enriched chow ad libitum; and CR + FO group - FO-enriched 30 % CR chow. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112770DOI Listing

Contextual processing elicits sex differences in dorsal hippocampus activation following footshock and context fear retrieval.

Behav Brain Res 2020 Jun 16;393:112771. Epub 2020 Jun 16.

Department of Psychology, University at Albany, State University of New York, Albany, NY, 12222 USA. Electronic address:

Establishing a contextual representation of an environment places specific spatial-temporal processing demands on the mammalian hippocampus, a region showing sex-differences in processing capabilities. However, evidence for sex differences in these processing demands during contextual fear learning remains limited. Here, we examined the relationship among contextual processing, timing of footshock, and activation of the dorsal hippocampus and basolateral amygdalar nuclei (BLA) in male and female mice (C57Bl/6 J). Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112771DOI Listing

Memory reconsolidation impairments in sign-tracking to an audiovisual compound stimulus.

Behav Brain Res 2020 Jun 15;393:112774. Epub 2020 Jun 15.

University of Birmingham, Birmingham, B15 2TT, UK. Electronic address:

Studies of memory reconsolidation of pavlovian memories have typically employed unimodal conditioned stimuli, despite the use of multimodal compound stimuli in other settings. Here we studied sign-tracking behaviour to a compound audiovisual stimulus. First, we observed not unexpectedly that sign-tracking was poorer to the audiovisual compound than to unimodal visual stimuli. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112774DOI Listing

Behavioral indicators of succeeding and failing under higher-challenge compulsion-like alcohol drinking in rat.

Behav Brain Res 2020 Jun 13;393:112768. Epub 2020 Jun 13.

Department of Neurology, UCSF, United States; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address:

Intake despite negative consequences (compulsivity) contributes strongly to the harm of alcohol use disorder, making the underlying psychological and circuit mechanisms of great importance. To gain insight into possible underlying action strategies, we compared rat licking microstructure across compulsion-like and non-compulsive conditions. We previously showed that drinking under a moderate-challenge, quinine-alcohol model (Alc-ModQ) shows less variable responding in many measures, suggesting a more automatic strategy to overcome challenge. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112768DOI Listing

The prefrontal cortex conscious and unconscious response to social/emotional facial expressions involve sex, hemispheric laterality, and selective activation of the central cardiac modulation.

Behav Brain Res 2020 Jun 20;393:112773. Epub 2020 Jun 20.

Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Graduation Program in Biosciences, Porto Alegre, RS, Brazil; Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Department of Basic Sciences/Physiology, Porto Alegre, RS, Brazil. Electronic address:

The human prefrontal cortex (PFC) processes complex sensory information for the elaboration of social behaviors. The non-invasive neuroimaging technique near-infrared spectroscopy (NIRS) identifies hemodynamic changes and concentration of oxygenated (HbO) and deoxygenated (HHb) hemoglobin in the cerebral cortex. We studied the responses detected by NIRS in the right and left PFC activation of 28 participants (n = 14 adult young females and males) while processing social/emotional facial expressions, i. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112773DOI Listing

Proximate and ultimate causes of ritual behavior.

Behav Brain Res 2020 Jun 13:112772. Epub 2020 Jun 13.

Department of Chemistry, Life Sciences and Environmental Sustainaibility, Unit of Behavioral Biology, University of Parma, Italy.

Ritual behaviour, intended as a specific, repetitive and rigid form of action flow, appears both in social and non-social environmental contexts, representing an ubiquitous phenomenon in animal life including human individuals and cultures. The purpose of this contribution is to investigate an evolutionary continuum in proximate and ultimate causes of ritual behavior. A phylogenetic homology in proximal mechanisms can be found, based on the repetition of genetically programmed and/or epigenetically acquired action patterns of behaviour. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112772DOI Listing

Event-related desynchronization of alpha and beta band neural oscillations predicts speech and limb motor timing deficits in normal aging.

Behav Brain Res 2020 Jun 12;393:112763. Epub 2020 Jun 12.

Speech Neuroscience Lab, Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, United States. Electronic address:

Normal aging is associated with decline of motor timing mechanisms implicated in planning and execution of movement. Evidence from previous studies has highlighted the relationship between neural oscillatory activities and motor timing processing in neurotypical younger adults; however, it remains unclear how normal aging affects the underlying neural mechanisms of movement in older populations. In the present study, we recorded EEG activities in two groups of younger and older adults while they performed randomized speech and limb motor reaction time tasks cued by temporally predictable and unpredictable sensory stimuli. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112763DOI Listing

Effect of combined treatment with aripiprazole and antidepressants on the MK-801-induced deficits in recognition memory in novel recognition test and on the release of monoamines in the rat frontal cortex.

Behav Brain Res 2020 Jun 11;393:112769. Epub 2020 Jun 11.

Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Pharmacology, 12 Smętna Street, Kraków, Poland; The Podhale State Higher Vocational School, Institute of Health Sciences, Faculty of Cosmetology,71 Kokoszków, Nowy Targ, Poland. Electronic address:

According to preclinical and clinical studies, the antidepressant-induced increase in the activity of atypical antipsychotics may efficiently improve the treatment of negative and some cognitive symptoms of schizophrenia. In the present study, we aimed to evaluate the effects of the antidepressants escitalopram and mirtazapine and the atypical antipsychotic drug aripiprazole, administered separately or in combination, on the MK-801-induced deficits in the recognition memory test and on the extracellular levels of monoamines and their metabolites in the rat frontal cortex. Based on the results of the behavioral tests, co-treatment with an ineffective dose of aripiprazole (0. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112769DOI Listing

Autistic-like behaviours and associated brain structural plasticity are modulated by oxytocin in maternally separated rats.

Behav Brain Res 2020 Jun 11;393:112756. Epub 2020 Jun 11.

Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Centre for Perinatal Medicine and Health, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Early psycho-social experiences influence the developing brain and possible onset of various neurodevelopmental disorders, such as Autism Spectrum Disorder (ASD). ASD is characterized by a variety of brain abnormalities, including alteration of oxytocin receptors in the brain. Recently, early life adverse experiences, such as maternal separation (MS), have been shown to constitute risk factors for ASD in preclinical studies. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112756DOI Listing

Anti-LINGO-1 antibody treatment improves chronic stress-induced spatial memory impairments and oligodendrocyte loss in the hippocampus.

Behav Brain Res 2020 Jun 11;393:112765. Epub 2020 Jun 11.

Department of Histology and Embryology, Chongqing Medical University, Chongqing 400016, PR China; Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing 400016, PR China. Electronic address:

Chronic exposure to stressful conditions may affect spatial learning and memory abilities and the brain structure, and disruptions in oligodendrocyte function may cause cognitive dysfunction. Leucine-rich repeat and immunoglobulin-like domain-containing protein 1 (LINGO-1) is a potent negative regulator of oligodendrocytes and axon myelination. However, the questions we sought to answer in this study are whether hippocampal oligodendrocytes are involved in the pathological process of spatial learning and memory impairments induced by chronic stress (CS) and whether antibodies targeting LINGO-1 improve stress-induced spatial learning and memory impairments by protecting the hippocampal oligodendrocytes in stressed rats. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112765DOI Listing

Antidepressant effect of BE360, a new selective estrogen receptor modulator, activated via CREB/BDNF, Bcl-2 signaling pathways in ovariectomized mice.

Behav Brain Res 2020 Jun 11;393:112764. Epub 2020 Jun 11.

Department of Pharmacology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.

We have previously reported that the carborane compound BE360, a novel selective estrogen receptor modulator, has a therapeutic potential against dementia. This study aimed to explore the effects and underlying mechanisms of BE360 on depression-like behaviors in ovariectomized (OVX) mice subjected to subchronic stress, which are postmenopausal depression models. BE360 was subcutaneously administrated using a mini-osmotic pump, for 2 weeks. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112764DOI Listing

Imbalance in cerebral protein homeostasis: Effects on memory consolidation.

Behav Brain Res 2020 Jun 11;393:112767. Epub 2020 Jun 11.

Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro, Qro., 76230, México. Electronic address:

The long-standing hypothesis that memory consolidation is dependent upon de novo protein synthesis is based primarily on the amnestic effects of systemic administration of protein synthesis inhibitors (PSIs). Early experiments on mice showed that PSIs produced interference with memory consolidation that was dependent on the doses of PSIs, on the interval between drug injection and training, and, importantly, on the degree and duration of protein synthesis inhibition in the brain. Surprisingly, there is a conspicuous lack of information regarding the relationship between the duration of protein synthesis inhibition produced by PSIs and memory consolidation in the rat, one of the species most widely used to study memory processes. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112767DOI Listing
June 2020
3.028 Impact Factor

Increased ethanol intake is associated with social anxiety in offspring exposed to ethanol on gestational day 12.

Behav Brain Res 2020 Jun 11;393:112766. Epub 2020 Jun 11.

Department of Psychology, Center for Development and Behavioral Neuroscience Binghamton University, Binghamton, NY13902, United States; Developmental Exposure Alcohol Research Center, Baltimore MD21201, Binghamton NY 13902, Syracuse NY13210, United States.

Prenatal alcohol exposure (PAE) can result in physical, cognitive, and neurological deficits termed Fetal Alcohol Spectrum Disorder (FASD). Deficits in social functioning associated with PAE are frequently observed and persist throughout the lifespan. Social impairments, such as social anxiety, are associated with increased alcohol abuse, which is also highly pervasive following PAE. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112766DOI Listing

Red-hot chili receptors: A systematic review of TRPV1 antagonism in animal models of psychiatric disorders and addiction.

Behav Brain Res 2020 Jun 10;393:112734. Epub 2020 Jun 10.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Transient Receptor Potential Vanilloid 1 (TRPV1) channels are non-selective cationic polymodal receptors gated by several different chemical and physical stimuli. TRPV1 receptors are distributed in several brain areas and interact with important neurotransmitter systems linked to mental disorders, such as endocannabinoid and opioid systems. The increasing number of results obtained in this field has recently attracted growing attention to these receptors as potential targets for the treatment of different psychiatric conditions. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112734DOI Listing

Touchscreen-based assessment of risky-choice in mice.

Behav Brain Res 2020 Jun 10;393:112748. Epub 2020 Jun 10.

Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA. Electronic address:

Addictions are characterized by choices made to satisfy the addiction despite the risk it could produce an adverse consequence. Here, we developed a murine version of a 'risky decision-making' task (RDT), in which mice could respond on a touchscreen panel to obtain either a large milkshake reward associated with varying probability of footshock, or a smaller amount of the same reward that was never punished. Results showed that (the following font is incorrectly smaller/subscripted) mice shifted choice from the large to small reward stimulus as shock probability increased. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112748DOI Listing

Intact olfactory memory in the 5xFAD mouse model of Alzheimer's disease from 3 to 15 months of age.

Behav Brain Res 2020 Jun 6;393:112731. Epub 2020 Jun 6.

Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, B3H 4R2, Canada. Electronic address:

Alzheimer's disease (AD) is an age-related neurodegenerative disorder that causes profound cognitive dysfunction. Deficits in olfactory memory occur in early stages of AD and may be useful in AD diagnosis. The 5xFAD mouse is a commonly used model of AD, as it develops neuropathology, cognitive and sensori-motor dysfunctions similar to those seen in AD. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112731DOI Listing

Frontal-midline theta frequency and probabilistic learning: A transcranial alternating current stimulation study.

Behav Brain Res 2020 Jun 4;393:112733. Epub 2020 Jun 4.

Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary; Brain, Memory and Language Research Group, Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary; Lyon Neuroscience Research Center (CRNL), INSERM, CNRS, Université Claude Bernard Lyon 1, Lyon, France. Electronic address:

Probabilistic learning is a fundamental cognitive ability that extracts and represents regularities of our environment enabling predictive processing during perception and acquisition of perceptual, motor, cognitive, and social skills. Previous studies show competition between neural networks related to executive function/working memory vs. probabilistic learning. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112733DOI Listing

Mouse Arm and hand movements in grooming are reaching movements: Evolution of reaching, handedness, and the thumbnail.

Behav Brain Res 2020 Jun 4;393:112732. Epub 2020 Jun 4.

Department of Neuroscience, Canadian Centre of Behavioural Neuroscience, University of Lethbridge, Canada. Electronic address:

Grooming in the mouse features hand licking and symmetric and asymmetric arm and hand "strokes" over the face and body to maintain pelage. Grooming is syntactically organized but the structure of individualized movements of the arm, hand, and tongue have not been examined. Here spontaneous and water-induced grooming was video recorded in free-moving and head-fixed mice and subject to frame-by-frame video inspection and kinematic analysis using Physics Tracker. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112732DOI Listing

T-type calcium channels regulate the acquisition and recall of conditioned fear in male, Wistar rats.

Behav Brain Res 2020 Jun 3;393:112747. Epub 2020 Jun 3.

Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada.

The T-type calcium channel blocker, Z944, has been used as a pharmacological tool to assess T-type calcium channel function and examined for use as an anti-epileptic. As Z944 affects fear learning and memory in a rodent model of absence epilepsy, it is important to determine the effect of Z944 on learning and memory in a non-disease outbred rodent strain. This study examined the dose-dependent effects (5 mg/kg, 10 mg/kg, i. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112747DOI Listing

Interactive virtual objects attract attention and induce exploratory behaviours in rats.

Behav Brain Res 2020 Jun 3;392:112737. Epub 2020 Jun 3.

Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea; KAIST Institute of Artificial Intelligence, KAIST, Daejeon 34141, Republic of Korea. Electronic address:

Animals use visual information to recognize the value of objects and respond with different behaviours, such as evasion or approach. While rodents show defensive behaviour toward an artificial looming stimulus that mimics an approaching avian predator, the visual feature that attracts them to targets with positive value, such as prey, remains unclear. Here, we reveal that rats show curiosity-related behaviours towards a virtual object on screen when it moves interactively with their movements, whereas they show less response to a static object, a regularly moving object, or interactive dislocation of the background. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112737DOI Listing