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    10978 results match your criteria Behavioural Brain Research [Journal]

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    Sex-Dependent Behavioral Impairments in the HdhQ350/+ Mouse Line.
    Behav Brain Res 2017 Sep 16. Epub 2017 Sep 16.
    Department of Pharmacology, University of Washington, Seattle, WA, 98195, United States; Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA, 98195, United States. Electronic address:
    Huntington's Disease (HD) is an autosomal dominant neurodegenerative disease characterized by gradual deterioration of motor and cognitive functions and development of psychiatric deficits. Animal models provide powerful means to study the pathological processes, molecular dysfunctions and symptoms associated with HD. We performed a longitudinal behavioral study of the newly developed HdhQ350/+ mouse line, a knock-in model that expresses a repeat of 350 glutamines. Read More

    Metabolic profiling of the effects of ginsenoside Re in an Alzheimer's disease mouse model.
    Behav Brain Res 2017 Sep 16. Epub 2017 Sep 16.
    Department of Gerontology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China. Electronic address:
    Alzheimer's disease (AD) is one of the major neurological diseases among the elderly, and there are presently no approved treatments that can slow its progression. It has been reported that ginsenoside Re (G-Re), an active pharmacological component of ginseng, can ameliorate the symptoms of AD, but the underlying mechanisms are not clear. The current study was designed to test the effects of G-Re by investigating the metabolite profiles of AD mice. Read More

    Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage.
    Behav Brain Res 2017 Sep 16. Epub 2017 Sep 16.
    Institute of Anatomy, University of Zürich, Switzerland; Institute of Human Movement Sciences and Sport, Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland. Electronic address:
    To evaluate permanent effects of hippocampal and prefrontal cortex lesion on spatial tasks, lesioned and sham-operated female C57BL mice were exposed to a series of conditioning schemes in IntelliCages housing 8-10 transponder-tagged mice from each treatment group. Sequential testing started at 51 to 172days after bilateral lesions and lasted for 154 and 218days in two batches of mice, respectively. Spontaneous undisturbed behavioral patterns clearly separated the three groups, hippocampals being characterized by more erratic hyperactivity, and strongly impaired circadian synchronization ability. Read More

    A role for nucleus accumbens glutamate in the expression but not the induction of behavioural sensitization to ethanol.
    Behav Brain Res 2017 Sep 14. Epub 2017 Sep 14.
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Behavioural Neurobiology Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Departments of Psychiatry and Psychology, University of Toronto, Toronto, ON, Canada.
    Mechanisms underlying differential sensitivity to behavioural sensitization to ethanol (EtOH) remain poorly understood, although accumulating evidence suggests a role for glutamatergic processes in the ventral striatum. Efforts to address this issue can benefit from the well-documented fact that in any given cohort, some of the mice (High sensitized; HS) show robust sensitization, while others (Low sensitized; LS) show little, if any, sensitization. Here, we examined whether this variability might be differentially associated with nucleus accumbens (NAc) glutamate processes. Read More

    Ethyl-acetate fraction of Trichilia catigua restores long-term retrograde memory and reduces oxidative stress and inflammation after global cerebral ischemia in rats.
    Behav Brain Res 2017 Sep 14. Epub 2017 Sep 14.
    Department of Pharmacology and Therapeutics, State University of Maringa, Maringá, Paraná, Brazil. Electronic address:
    We originally reported that an ethyl-acetate fraction (EAF) of Trichilia catigua prevented the impairment of water maze learning and hippocampal neurodegeneration after transient global cerebral (TGCI) in mice. We extended that previous study by evaluating whether T. catigua (i) prevents the loss of long-term retrograde memory assessed in the aversive radial maze (AvRM), (ii) confers hippocampal and cortical neuroprotection, and (iii) mitigates oxidative stress and neuroinflammation in rats that are subjected to the four vessel occlusion (4-VO) model of TGCI. Read More

    The plasmalogen precursor analog PPI-1011 reduces the development of L-DOPA-induced dyskinesias in de novo MPTP monkeys.
    Behav Brain Res 2017 Sep 14. Epub 2017 Sep 14.
    Neuroscience Research Unit, Centre de Recherche du CHU de Québec, CHUL, 2705 Laurier Boulevard, Quebec City, Qc, G1V 4G2, Canada; Faculty of Pharmacy, Laval University, 1050, avenue de la Médecine, Quebec City, Qc, G1V 0A6, Canada. Electronic address:
    The gold standard therapy for Parkinson's disease (PD), L-3,4-dihydroxyphenylalanine (L-DOPA), induces dyskinesias in the majority of patients after years of treatment. Ethanolamine plasmalogens (PlsEtn) play critical roles in membrane structure mediated functions and as a storage depot of polyunsaturated fatty acids such as docosahexaenoic acid. We previously showed that a PlsEtn precursor PPI-1011 reduced already established L-DOPA-induced dyskinesias (LID) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned monkeys as a PD model. Read More

    Altered serotonergic and GABAergic neurotransmission in a mice model of obsessive-compulsive disorder.
    Behav Brain Res 2017 Sep 12. Epub 2017 Sep 12.
    Dept of Psychiatry, Charite, Campus Mitte, Berlin, Germany. Electronic address:
    There is ample evidence that obsessive-compulsive disorder (OCD) is based on reduced serotonergic function. Replicated bidirectional selection for thermoregulatory nest-building behavior in the laboratory house mouse (Mus musculus) resulted in compulsive-like, non-compulsive-like and randomly bred control mice that represent a non-induced animal model of OCD. The present study aimed at investigating the neurochemical patterns in specific brain regions of compulsive-like (HA) versus non-compulsive-like (LA) and normal (CA) mice. Read More

    Sociability trait and regional cerebral oxidative metabolism in rats: Predominantly nonlinear relations.
    Behav Brain Res 2017 Sep 12. Epub 2017 Sep 12.
    Division of Neuropsychopharmacology, Department of Psychology, University of Tartu, Ravila 14A, Chemicum, 50411 Tartu, Estonia. Electronic address:
    Deficits in social behaviour are common in psychopathological conditions e.g., depression, autism and schizophrenia. Read More

    Awakenings in rats by ultrasounds: A new animal model for paradoxical kinesia.
    Behav Brain Res 2017 Sep 13. Epub 2017 Sep 13.
    Experimental and Biological Psychology, Behavioral Neuroscience, Faculty of Psychology, Philipps-University of Marburg, Gutenbergstrasse 18, 35032 Marburg, Germany; Behavioral Neurosciences Institute (INeC), Av. do Café, 2450, Monte Alegre, Ribeirão Preto, 14050-220, São Paulo, Brazil. Electronic address:
    Paradoxical kinesia refers to a sudden transient ability of akinetic patients to perform motor tasks they are otherwise unable to perform. The mechanisms underlying this phenomenon are unknown due a paucity of valid animal models that faithfully reproduce paradoxical kinesia. Here, in a first experiment, we present a new method to study paradoxical kinesia by "awakening" cataleptic rats through presenting appetitive 50-kHz ultrasonic vocalizations (USV), which are typical for social situations with positive valence, like juvenile play or sexual encounters ("rat laughter"). Read More

    Early-Life Stress Modulates Neural Networks Associated with Habitual Use of Reappraisal.
    Behav Brain Res 2017 Sep 12. Epub 2017 Sep 12.
    Klinik und Hochschulambulanz für Psychiatrie und Psychotherapie, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8032 Zurich, Switzerland.
    Recent evidence shows that early life stress (ELS) is associated with altered resting-state functional connectivity (RSFC) between amygdala and the prefrontal cortex, as well as with maladaptive emotion regulation strategies and negative mood. However, the relation between ELS and maladaptive emotion regulation is not deterministic. Adaptive emotion regulation strategies such as reappraisal can also ensue from experience and learning in adulthood and can prevent negative mood. Read More

    Acute alerting effects of light: a systematic literature review.
    Behav Brain Res 2017 Sep 11. Epub 2017 Sep 11.
    Philips Research (Department Brain, Behavior & Cognition), Eindhoven, The Netherlands.
    Periodic, well timed exposure to light is important for our health and wellbeing. Light, in particular in the blue part of the spectrum, is thought to affect alertness both indirectly, by modifying circadian rhythms, and directly, giving rise to acute effects. We performed a systematic review of empirical studies on direct, acute effects of light on alertness to evaluate the reliability of these effects and to assess to what extent they depend on other factors, such as time of day, exposure duration and sleep pressure. Read More

    Acid-sensing ion channel 1 contributes to normal olfactory function.
    Behav Brain Res 2017 Sep 12. Epub 2017 Sep 12.
    Department of Neurobiology, Morehouse School of Medicine, Atlanta, Georgia. Electronic address:
    Acid-sensing ion channels (ASICs) are cation channels activated by protons. ASIC1a, a primary ASIC subunit in the brain, was recently characterized in the olfactory bulb. The present study tested the hypothesis that ASIC1a is essential for normal olfactory function. Read More

    The effects of aerobic exercise on depression-like, anxiety-like, and cognition-like behaviours over the healthy adult lifespan of C57BL/6 mice.
    Behav Brain Res 2017 Sep 11. Epub 2017 Sep 11.
    The University of Adelaide, School of Medicine, Discipline of Psychiatry, Adelaide, Australia. Electronic address:
    Preclinical studies have demonstrated exercise improves various types of behaviours such as anxiety-like, depression-like, and cognition-like behaviours. However, these findings were largely conducted in studies utilising short-term exercise protocols, and the effects of lifetime exercise on these behaviours remain unknown. This study investigates the behavioural effects of lifetime exercise in normal healthy aging C57BL/6 mice over the adult lifespan. Read More

    Correlation between brain circuit segregation and obesity.
    Behav Brain Res 2017 Sep 9. Epub 2017 Sep 9.
    Department of Psychiatry/Health Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi, Taiwan; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan. Electronic address:
    Obesity is a major public health problem. Herein, we aim to identify the correlation between brain circuit segregation and obesity using multimodal functional magnetic resonance imaging (fMRI) techniques and analysis. Twenty obese patients (BMI=37. Read More

    A facilitating role for the primary motor cortex in action sentence processing.
    Behav Brain Res 2017 Sep 9;336:244-249. Epub 2017 Sep 9.
    Département de Réadaptation, Université Laval, Québec, QC, Canada; CERVO Brain Research Center, Québec, QC, Canada. Electronic address:
    The involvement of the motor system in action language comprehension is a hotly debated topic in cognitive neuroscience and psychology. Recent studies suggest that primary motor cortex (M1) response to action language is context-sensitive rather than automatic and necessary. Specifically, semantic polarity (i. Read More

    Information content of dendritic spines after motor learning.
    Behav Brain Res 2017 Sep 9;336:256-260. Epub 2017 Sep 9.
    Institute of Genetics and Biophysics "Adriano Buzzati Traverso", CNR, Naples, Italy; Department of Pharmacy, University of Naples Federico II, Naples, Italy.
    Dendritic spines, small protrusions emerging from the dendrites of most excitatory synapses in the mammalian brain, are highly dynamic structures and their shape and number is continuously modulated by memory formation and other adaptive changes of the brain. In this study, using a behavioral paradigm of motor learning, we applied the non-linear analysis of dendritic spines to study spine complexity along dendrites of cortical and subcortical neural systems, such as the basal ganglia, that sustain important motor learning processes. We show that, after learning, the spine organization has greater complexity, as indexed by the maximum Lyapunov exponent (LyE). Read More

    Caffeine has no effect on eyeblink conditioning in mice.
    Behav Brain Res 2017 Sep 8. Epub 2017 Sep 8.
    Department of Neuroscience, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands.
    Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that require the cerebellar cortex, such as eyeblink conditioning. Read More

    Applicability of the grip strength and automated von Frey tactile sensitivity tests in the mouse photothrombotic model of stroke.
    Behav Brain Res 2017 Sep 8;336:250-255. Epub 2017 Sep 8.
    Department of Pharmaceutical Sciences, School of Pharmacy, TTUHSC, United States; Center for Blood Brain Barrier Research, School of Pharmacy, TTUHSC, United States. Electronic address:
    Improvement of impaired neurological function(s) is a primary endpoint in experimental stroke recovery studies, making the choice and nature of the functional tests crucial for proper execution and interpretation of such studies. Currently, there are a limited number of neurological tests which reliably evaluate functional deficit in mice over a long period of time after stroke. In this study, we evaluated the applicability of forepaw grip strength and automated von Frey tactile sensitivity tests to assess forelimb dysfunction in mice following photothrombosis in the sensorimotor cortex, and compared them with two well-established tests, grid-walking and cylinder, for up to 21days after stroke. Read More

    Motor function deficits in the 12 month-old female 5xFAD mouse model of Alzheimer's disease.
    Behav Brain Res 2017 Sep 7. Epub 2017 Sep 7.
    Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, B3H 4R2, Canada. Electronic address:
    Motor problems occur early in some patients with Alzheimer's disease (AD) and as the disease progresses many patients develop motor dysfunction. Motor dysfunction has been reported in some mouse models of AD, including the 5xFAD mouse, thus this model may be particularly useful for studying motor dysfunction in AD. In order to determine the extent of motor dysfunction in these mice, we tested 11-13 month old female 5xFAD and wildtype (WT) control mice in a battery of motor behaviour tasks. Read More

    Suppression of FoxO3a attenuates neurobehavioral deficits after traumatic brain injury through inhibiting neuronal autophagy.
    Behav Brain Res 2017 Sep 6. Epub 2017 Sep 6.
    Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
    Traumatic brain injury (TBI) is a serious insult that frequently leads to neurological impairments. Forkhead box O (FoxO) 3a, as transcription factor, has been confirmed to modulate autophagic process. Moreover, FoxO3a is expressed throughout the brain including the hippocampus. Read More

    Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model.
    Behav Brain Res 2017 Sep 6;336:236-243. Epub 2017 Sep 6.
    Department of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Laboratory of Brain Disorders (Ministry of Science and Technology), Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China. Electronic address:
    Oxytocin (OXT) has been considered as a neuroregulator mediating social behaviors and stress-related disorders. Recent clinical studies suggest that OXT might also act as antidepressant in postpartum depression (PPD) patients, but the mechanism is still unknown. In the present study, we explored the effect of OXT in paraventricular nucleus (PVN) and possible signaling pathway involved in a PPD rat model induced by gestation restraint stress (GRS). Read More

    Mindfulness and dynamic functional neural connectivity in children and adolescents.
    Behav Brain Res 2017 Sep 5;336:211-218. Epub 2017 Sep 5.
    Department of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI, 48201, United States; Department of Pharmaceutical Sciences, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI, 48201, United States; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, United States.
    Background: Interventions that promote mindfulness consistently show salutary effects on cognition and emotional wellbeing in adults, and more recently, in children and adolescents. However, we lack understanding of the neurobiological mechanisms underlying mindfulness in youth that should allow for more judicious application of these interventions in clinical and educational settings.

    Methods: Using multi-echo multi-band fMRI, we examined dynamic (i. Read More

    Reduction in open field activity in the absence of memory deficits in the App(NL-G-F) knock-in mouse model of Alzheimer's disease.
    Behav Brain Res 2017 Sep 5;336:177-181. Epub 2017 Sep 5.
    Lysosomal Diseases Research Unit, Nutrition and Metabolism Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, Australia. Electronic address:
    The recent development of knock-in mouse models of Alzheimer's disease provides distinct advantages over traditional transgenic mouse models that rely on over-expression of amyloid precursor protein. Two such knock-in models that have recently been widely adopted by Alzheimer's researchers are the App(NL-F) and App(NL-G-F) mice. This study aimed to further characterise the behavioural phenotype and amyloid plaque distribution of App(NL-G-F/NL-G-F) (C57BL/6J background) mice at six-months of age. Read More

    Enhanced expression of heme oxygenase-1 in the locus coeruleus can be associated with anxiolytic-like effects.
    Behav Brain Res 2017 Sep 5;336:204-210. Epub 2017 Sep 5.
    Psychobiology Graduation Program, School of Philosophy, Science and Literature of Ribeirão Preto of the University of São Paulo, 14040-901 Ribeirão Preto, SP, Brazil; Department of Morphology, Physiology and Basic Pathology, Ribeirão Preto Dentistry School of the University of São Paulo, 14040-904, Ribeirão Preto, SP, Brazil. Electronic address:
    Some researchers have shown that carbon monoxide (CO) plays a role in emotional behavior modulation through intracellular 3'-5'-guanosine monophosphate mechanisms in the locus coeruleus (LC). In fact, the LC region has a high expression of the heme-oxygenase (HO) enzymes, which are responsible for the production of CO. However, the physiological mechanism by which the HO-CO pathway participates in the modulation of emotional responses in the LC still needs clarification. Read More

    Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease.
    Behav Brain Res 2017 Sep 6;336:219-226. Epub 2017 Sep 6.
    School of Life Sciences, Zhengzhou University, Zhengzhou 450001, People's Republic of China. Electronic address:
    Accumulating evidence suggests that oxidative stress induced by beta-amyloid (Aβ) is implicated in the pathlogical progression of Alzheimer's disease (AD). 3H-1,2-dithiole-3-thione (D3T), the simplest compound of the sulfur-containing dithiolethiones, has been proved to be a strongly active antioxidant factor by regulation of the nuclear factor E2-related factor 2 (Nrf2). Previous study reported that D3T confers protection to AD cell model in vitro, however, the neuroprotective effect of D3T in the AD mammalian model is unknown. Read More

    Hypoxia-inducible factor-1α is involved in isoflurane-induced blood-brain barrier disruption in aged rats model of POCD.
    Behav Brain Res 2017 Sep 5. Epub 2017 Sep 5.
    Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China. Electronic address:
    Prolonged exposure to inhaled anesthetics may lead to postoperative cognitive dysfunction (POCD). Nevertheless, the underlying mechanisms are not known. Hypoxia-inducible factor-1α (HIF-1α) and its target gene vascular endothelial growth factor (VEGF) were shown to be activated by inhaled anesthetics. Read More

    Effects of an acute therapeutic or rewarding dose of amphetamine on acquisition of Pavlovian autoshaping and ventral striatal dopamine signaling.
    Behav Brain Res 2017 Sep 5;336:191-203. Epub 2017 Sep 5.
    School of Biological Sciences, Illinois State University, Campus Box 4120 Normal, IL 61790-4120, USA. Electronic address:
    Rewarding doses of amphetamine increase the amplitude, duration, and frequency of dopamine transients in the ventral striatum. Debate continues at the behavioral level about which component of reward, learning or incentive salience, is signaled by these dopamine transients and thus altered in addiction. The learning hypothesis proposes that rewarding drugs result in pathological overlearning of drug-predictive cues, while the incentive sensitization hypothesis suggests that rewarding drugs result in sensitized attribution of incentive salience to drug-predictive cues. Read More

    Embryonic alcohol exposure leading to social avoidance and altered anxiety responses in adult zebrafish.
    Behav Brain Res 2017 Sep 4. Epub 2017 Sep 4.
    Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense - UNESC, Av. Universitária, 1105, Bairro Universitário, 88806-000 Criciúma, SC, Brazil. Electronic address:
    Fetal Alcohol Spectrum Disorders (FASD) is a syndrome characterized by neurological and behavioral impairments. A recently discovered hallmark of FASD is impaired social behavior. Avoidance of social interaction typical of FASD may be the result of increased anxiety. Read More

    Different effects of running wheel exercise and skilled reaching training on corticofugal tract plasticity in hypertensive rats with cortical infarctions.
    Behav Brain Res 2017 Sep 4;336:166-172. Epub 2017 Sep 4.
    Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. Electronic address:
    The approaches that facilitate white matter plasticity may prompt functional recovery after a stroke. The effects of different exercise methods on motor recovery in stroke rats have been investigated. However, it is not clear whether their effects on axonal plasticity different. Read More

    Hippocampal theta phase-contingent memory retrieval in delay and trace eyeblink conditioning.
    Behav Brain Res 2017 Sep 4. Epub 2017 Sep 4.
    Department of Psychology, P.O. Box 35, 40014, University of Jyvaskyla, Finland.
    Hippocampal theta oscillations (3-12Hz) play a prominent role in learning. It has been suggested that encoding and retrieval of memories are supported by different phases of the theta cycle. Our previous study on trace eyeblink conditioning in rabbits suggests that the timing of the conditioned stimulus (CS) in relation to theta phase affects encoding but not retrieval of the memory trace. Read More

    Is that disgust I see? Political ideology and biased visual attention.
    Behav Brain Res 2017 Sep 5;336:227-235. Epub 2017 Sep 5.
    West Virginia University, Department of Psychology, P.O. Box 6040, Campus Drive, Morgantown, WV, 26505, USA.
    Considerable evidence suggests that political liberals and conservatives vary in the way they process and respond to valenced (i.e., negative versus positive) information, with conservatives generally displaying greater negativity biases than liberals. Read More

    Increased emotional reactivity to affective pictures in patients with skin-picking disorder: Evidence from functional magnetic resonance imaging.
    Behav Brain Res 2017 Sep 1;336:151-155. Epub 2017 Sep 1.
    Clinical Psychology, University of Graz, BioTechMedGraz, Universitätsplatz 2, 8010 Graz, Austria.
    The predominant symptom of skin-picking disorder (SPD) is the recurrent picking of one's own skin, leading to tissue damage and discomfort. Psychological disorder models suggest an enhanced emotional reactivity in patients with SPD, which contributes to the maintenance of symptoms. This functional magnetic resonance imaging (fMRI) experiment analyzed both subjective and neuronal responses to affective pictures (categories: fear, disgust, happiness, neutral) in 19 women with SPD and 16 healthy controls. Read More

    Differential effects of imipramine and CORT118335 (Glucocorticoid receptor modulator/mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats.
    Behav Brain Res 2017 Sep 1;336:99-110. Epub 2017 Sep 1.
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA; Neuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Experimental Psychology Graduate Program, University of Cincinnati, Cincinnati, OH, USA. Electronic address:
    Depression is commonly associated with hypothalamic-pituitary adrenal (HPA) axis dysfunction that primarily manifests as aberrant glucocorticoid secretion. Glucocorticoids act on Type I mineralocorticoid (MR) and Type II glucocorticoid receptors (GR) to modulate mood and endocrine responses. Successful antidepressant treatment normalizes HPA axis function, in part due to modulatory effects on MR and GR in cortico-limbic structures. Read More

    Inhibition of GABA A receptor improved special memory impairment in the local model of demyelination in rat hippocampus.
    Behav Brain Res 2017 Sep 1;336:111-121. Epub 2017 Sep 1.
    Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Physiology Departments, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran. Electronic address:
    Cognitive impairment and memory deficit are common features in multiple Sclerosis patients. The mechanism of memory impairment in MS is unknown, but neuroimaging studies suggest that hippocampal demyelination is involved. Here, we investigate the role of GABA A receptor on spatial memory in the local model of hippocampal demyelination. Read More

    Melatonin prevents memory impairment induced by high-fat diet: Role of oxidative stress.
    Behav Brain Res 2017 Sep 1;336:93-98. Epub 2017 Sep 1.
    Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
    Consumption of high-fat diet (HFD) induces oxidative stress in the hippocampus that leads to memory impairment. Melatonin has antioxidant and neuroprotective effects. In this study, we hypothesized that chronic administration of melatonin can prevent memory impairment induced by consumption of HFD. Read More

    Differential effects of relaxin-3 and a selective relaxin-3 receptor agonist on food and water intake and hypothalamic neuronal activity in rats.
    Behav Brain Res 2017 Aug 31;336:135-144. Epub 2017 Aug 31.
    Faculté de Médecine, Département de Psychiatrie et de Neurosciences, Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec (QC), G1V 0A6, Canada. Electronic address:
    The neuropeptide relaxin-3 (RLN3) binds with high affinity to its cognate receptor, relaxin-family peptide receptor 3 (RXFP3), and with lower affinity to RXFP1, the cognate receptor for relaxin. Intracerebroventricular (icv) administration of RLN3 in rats strongly increases food and water intake and alters the activity of the hypothalamic-pituitary-adrenal (HPA) and gonadal (HPG) axes, but the relative involvement of RXFP3 and RXFP1 in these effects is not known. Therefore, the effects of icv administration of equimolar (1. Read More

    Mice lacking hippocampal left-right asymmetry show non-spatial learning deficits.
    Behav Brain Res 2017 Aug 31;336:156-165. Epub 2017 Aug 31.
    Advanced Research Centers, Keio University, 2-15-45, Mita, Minato-ku, Tokyo, Japan.
    Left-right asymmetry is known to exist at several anatomical levels in the brain and recent studies have provided further evidence to show that it also exists at a molecular level in the hippocampal CA3-CA1 circuit. The distribution of N-methyl-d-aspartate (NMDA) receptor NR2B subunits in the apical and basal synapses of CA1 pyramidal neurons is asymmetrical if the input arrives from the left or right CA3 pyramidal neurons. In the present study, we examined the role of hippocampal asymmetry in cognitive function using β2-microglobulin knock-out (β2m KO) mice, which lack hippocampal asymmetry. Read More

    The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice.
    Behav Brain Res 2017 Aug 31;336:77-84. Epub 2017 Aug 31.
    Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8553, Japan.
    We previously reported that systemic administration of the selective delta opioid receptor (DOP) agonist KNT-127 produces potent anxiolytic-like effects in rats. Although a higher distribution pattern of DOPs was reported in the prelimbic medial prefrontal cortex (PL-PFC) of rodents, the role of DOPs in PL-PFC and in anxiolytic-like effects have not been well examined. Recently, we demonstrated that activation of PL-PFC with the sodium channel activator veratrine increases glutamatergic neurotransmission and produces anxiety-like behaviors in mice. Read More

    Socially dominant mice in C57BL6 background show increased social motivation.
    Behav Brain Res 2017 Aug 30;336:173-176. Epub 2017 Aug 30.
    Neuroscience Program, Michigan State University, East Lansing, MI 48824, United States; Department of Physiology, Michigan State University, East Lansing, MI 48824, United States. Electronic address:
    A series of behavioral tests measuring social dominance, social motivation, and non-social motivation are examined in adult male C57BL6 mice. By using the well-known tube dominance test to determine social dominance and rank, we find that, in the absence of competition for resource and mating, group-housed mouse cage-mates display stable and mostly linear and transitive social hierarchies. Mice with top and bottom social ranks are subjected to a three-chamber social interaction test to measure social motivation. Read More

    Long-term behavioral sensitization to apomorphine is independent of conditioning and increases conditioned pecking, but not preference, in pigeons.
    Behav Brain Res 2017 Aug 30;336:122-134. Epub 2017 Aug 30.
    Faculty of Psychology, Department of Biopsychology, University of Bochum, 150 Universitätsstraße, D-44801 Bochum, Germany.
    When rodents are given a free choice between a variable option and a constant option, they may prefer variability. This preference is even sometimes increased following repeated administration of a dopamine agonist. The present study was the first to examine preference for variability under the systemic administration of a dopamine agonist, apomorphine (Apo), in birds. Read More

    Prenatal stress induced gender-specific alterations of N-methyl-d-aspartate receptor subunit expression and response to Aβ in offspring hippocampal cells.
    Behav Brain Res 2017 Sep 9;336:182-190. Epub 2017 Sep 9.
    Department of Anatomy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China. Electronic address:
    Prenatal stress (PS) is one of adverse life events during pregnancy, which may increase vulnerability to cognitive impairment in adult offspring. Aβ synaptotoxicity is one important pathological factor for cognitive impairment, and PS-induced cognitive disorder is closely associated with N-Methyl-d-Aspartate receptor (NMDAR), which acts as a key mediator of Aβ synaptotoxicity. In the present study, we tried to explore whether PS affects offspring's Aβ levels and NMDAR subunit expression in a gender-specific manner in hippocampal CA and DG subregions, and whether PS affects synaptic proteins and NMDAR subunit expression in cultured offspring hippocampal cells exposed to Aβ. Read More

    The effect of an acute systemic inflammatory insult on the chronic effects of a single mild traumatic brain injury.
    Behav Brain Res 2017 Aug 29;336:22-31. Epub 2017 Aug 29.
    Discipline of Anatomy and Pathology, Adelaide Medical School, University of Adelaide, Adelaide, Australia. Electronic address:
    A small but significant proportion of mild traumatic brain injury (mTBI) sufferers will report persistent symptoms, including depression, anxiety and cognitive deficits, in the months, or even years, following the initial event. This is known as post-concussion syndrome and its pathogenesis is not yet known. This study sought to investigate the role of a peripheral inflammatory insult in the development of ongoing behavioral symptoms following a mTBI. Read More

    Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury.
    Behav Brain Res 2017 Aug 26;336:32-39. Epub 2017 Aug 26.
    Department of Pathophysiology, Chongqing Medical University, Chongqing, People's Republic of China. Electronic address:
    The nod-like receptor protein 3 (NLRP3) inflammasome has a critical role in inflammation damage in ischemic injury, and the activation of the inflammasome is closely related to the interaction with thioredoxin interacting protein (TXNIP), which dissociates from the thioredoxin1 (Trx1)/TXNIP complex under oxidative stress. However, the negative regulator of NLRP3 inflammasome activation has not been fully investigated. Nuclear factor erythroid 2-related factor 2 (Nrf2) takes on a critical part in the antioxidant stress system, that controls the driven genes of antioxidant response element (ARE). Read More

    Spaced sessions of avoidance extinction reduce spontaneous recovery and promote infralimbic cortex activation.
    Behav Brain Res 2017 Aug 26;336:59-66. Epub 2017 Aug 26.
    Autonomous University of Barcelona, Department of Psychobiology and Methodology of Life Sciences. Institute of Neurosciences. 08193 Bellaterra, Barcelona, Spain. Electronic address:
    Extinction-based therapies (EBT) are the psychological treatments of choice for certain anxiety disorders, such as post-traumatic stress disorder. However, some patients relapse and suffer spontaneous recovery (SR) of anxiety symptoms and persistence of avoidance behaviour, which underlines the need for improving EBT. In rats, recent evidence has highlighted the relevance of the temporal distribution of extinction sessions in reducing SR of auditory fear conditioning, although it has seldom been studied in procedures involving proactive avoidance responses, such as two-way active avoidance conditioning (TWAA). Read More

    A motorized pellet dispenser to deliver high intensity training of the single pellet reaching and grasping task in rats.
    Behav Brain Res 2017 Aug 25;336:67-76. Epub 2017 Aug 25.
    Neuroscience and Mental Health Institute, Faculty of Rehabilitation Medicine, 3-88 Corbett Hall, University of Alberta, Edmonton, AB T6E 2G4, Canada; Department of Physical Therapy, Faculty of Rehabilitation Medicine, 3-88 Corbett Hall, University of Alberta, Edmonton, AB T6E 2G4, Canada. Electronic address:
    The single pellet reaching and grasping (SPG) task is widely used to study forelimb motor performance in rodents and to provide rehabilitation after neurological disorders. Nonetheless, the time necessary to train animals precludes its use in settings where high-intensity training is required. In the current study, we developed a novel high-intensity training protocol for the SPG task based on a motorized pellet dispenser and a dual-window enclosure. Read More

    Sex effects on spatial learning but not on spatial memory retrieval in healthy young adults.
    Behav Brain Res 2017 Aug 25;336:44-50. Epub 2017 Aug 25.
    Department of Psychiatry, Charité - Universitätsmedizin Berlin, Germany.
    Objectives: Sex differences have been found in spatial learning and spatial memory, with several studies indicating that males outperform females. We tested in the virtual Morris Water Maze (vMWM) task, whether sex differences in spatial cognitive processes are attributable to differences in spatial learning or spatial memory retrieval in a large student sample.

    Methods: We tested 90 healthy students (45 women and 45 men) with a mean age of 23. Read More

    Tolerance to rewarding brain electrical stimulation: Differential effects of contingent and non-contingent activation of parabrachial complex and lateral hypothalamus.
    Behav Brain Res 2017 Aug 24;336:15-21. Epub 2017 Aug 24.
    Department of Psychobiology and Mind, Brain, and Behavior Research Center (CIMCYC), Campus of Cartuja, University of Granada, Granada 18071, Spain.
    Electrical stimulation of the parabrachial complex and related insular cortex induces concurrent conditioned place preference (CPP) in a naloxone-dependent manner. Furthermore, repeated rewarding activation of these regions generates tolerance, i.e. Read More

    Administration of riluzole to the basolateral amygdala facilitates fear extinction in rats.
    Behav Brain Res 2017 Aug 24;336:8-14. Epub 2017 Aug 24.
    Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashimachi, Kodaira, Tokyo 187-8553, Japan. Electronic address:
    A general understanding exists that inhibition of glutamatergic neurotransmission in the basolateral amygdala (BLA) impairs fear extinction in rodents. Surprisingly, we recently found that systemic administration of riluzole, which has been shown to inhibit the glutamatergic system, facilitates extinction learning in rats with a preconditioned contextual fear response. However, the mechanisms underlying this paradoxical effect of riluzole remain unclear. Read More

    Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders.
    Behav Brain Res 2017 Aug 24;336:1-7. Epub 2017 Aug 24.
    Institute of Anatomy, Medical Faculty, Otto-von-Guericke-University, Leipziger Str. 44, 39120 Magdeburg, Germany. Electronic address:
    Plasticity related gene 1 (PRG-1) is a neuron specific membrane protein located at the postsynaptic density of glutamatergic synapses. PRG-1 modulates signaling pathways of phosphorylated lipid substrates such as lysophosphatidic acid (LPA). Deletion of PRG-1 increases presynaptic glutamate release probability leading to neuronal over-excitation. Read More

    Dopamine D1 receptor activation maintains motor coordination in injured rats but does not accelerate the recovery of the motor coordination deficit.
    Behav Brain Res 2017 Aug 31;336:145-150. Epub 2017 Aug 31.
    División de Neurociencias, Instituto Nacional de Rehabilitación,'Luis Guillermo Ibarra Ibarra', Secretaría de Salud, Calzada México-Xochimilco 289, Arenal de Guadalupe, C.P. 14389, Mexico City, Mexico. Electronic address:
    The sensorimotor cortex and the striatum are interconnected by the corticostriatal pathway, suggesting that cortical injury alters the striatal function that is associated with skilled movements and motor learning, which are functions that may be modulated by dopamine (DA). In this study, we explored motor coordination and balance in order to investigate whether the activation of D1 receptors (D1Rs) modulates functional recovery after cortical injury. The results of the beam-walking test showed motor deficit in the injured group at 24, 48 and 96h post-injury, and the recovery time was observed at 192h after cortical injury. Read More

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