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    11174 results match your criteria Behavioural Brain Research [Journal]

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    Daily maternal separations during stress hyporesponsive period decrease the thresholds of panic-like behaviors to electrical stimulation of the dorsal periaqueductal gray of the adult rat.
    Behav Brain Res 2018 Feb 18. Epub 2018 Feb 18.
    Department of Physiological Sciences, Health Science Center, Federal University of EspíritoSanto, Brazil. Electronic address:
    The present study examined whether early life maternal separation (MS), a model of childhood separation anxiety, predisposes to panic at adulthood. For this purpose, male pups were submitted to 3-h daily maternal separations along postnatal (PN) days of either the 'stress hyporesponsive period' (SHRP) from PN4 to PN14 (MS11) or throughout lactation from PN2 to PN21 (MS20). Pups were further reunited to conscious (CM) or anesthetized (AM) mothers to assess the effect of mother-pup interaction upon reunion. Read More

    Neuroinflammation in Alzheimer's Disease: Pleiotropic Roles for Cytokines and Neuronal Pentraxins.
    Behav Brain Res 2018 Feb 17. Epub 2018 Feb 17.
    Department of Food Science and Human Nutrition, Iowa State University, 2312 Food Sciences Building, 536 Farm House Lane, Ames, IA 50011, United States; Department of Psychology, Iowa State University, W112 Lagomarcino Hall, 901 Stange Road, Ames, IA 50011, United States; Department of Biomedical Sciences, Iowa State University, 2008 Veterinary Medicine, Ames, IA 50011, United States; Department of Neurology, University of Iowa, 2007 Roy Carver Pavilion, 200 Hawkins Drive, Iowa City, IA 52242, United States. Electronic address:
    Neuroinflammation is a potential factor speculated to underlie Alzheimer's disease (AD) etiopathogenesis and progression. The overwhelming focus in this area of research to date has been on the chronic upregulation of pro-inflammatory cytokines to understand how neuroinflammatory mechanisms contribute to neurodegeneration. Yet, it is important to understand the pleiotropic roles of these cytokines in modulating neuroinflammation in which they cannot be labeled as a strictly "good" or "bad" biomarker phenotype. Read More

    The role of intraamygdaloid neurotensin and dopamine interaction in conditioned place preference.
    Behav Brain Res 2018 Feb 17. Epub 2018 Feb 17.
    Institute of Physiology, University of Pécs, Medical School, Pécs, Hungary; Neuroscience Center, University of Pécs, Pécs, Hungary; Molecular Endocrinology and Neurophysiology Research Group, University of Pécs, Szentágothai Center, Pécs, Hungary.
    Tridecapeptide Neurotensin (NT) is widely distributed in the central nervous system where it acts as a neurotransmitter and neuromodulator. The central nucleus of amygdala (CeA), part of the limbic system, plays an important role in learning, memory, anxiety and reinforcing mechanisms. Our previous data showed that NT microinjected into the CeA has positive reinforcing properties. Read More

    Fluctuations of extracellular glucose and lactate in the mouse primary visual cortex during visual stimulation.
    Behav Brain Res 2018 Feb 16. Epub 2018 Feb 16.
    School of Psychology, University of Ottawa, Canada. Electronic address:
    We measured the extracellular glucose and lactate in the primary visual cortex in the CD-1 mouse using electrochemical electrodes. To gain some additional information on brain metabolism, we examined the impact of systemic injections of lactate and fructose on the brain extracellular glucose and lactate changes observed during visual stimulation. We found that simple stimulation using a flashlight produced a decrease in visual cortex extracellular glucose and an increase in extracellular lactate. Read More

    Neural pathways in 'emotional approach' as experiential emotion regulation strategy.
    Behav Brain Res 2018 Feb 15. Epub 2018 Feb 15.
    Department of Clinical and Lifespan Psychology, Vrije Universiteit Brussel, Pleinlaan 2, B- 1050 Brussel, Belgium; Department of Medical Imaging, University of Antwerp, Antwerp, Belgium; Personality, Motivation and Social Psychology Laboratory, University of Osnabrück, Osnabrück, Germany; Department of Radiology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussel, Belgium.
    Current research on emotion shows an increasing interest in the neuronal correlates of emotion regulation (ER). While previous research on ER has focused on gray matter correlates, this study represents the first exploratory study on white matter integrity and brain networks of ER. Responding to the gap between cognitive and affective approaches of ER, pertaining to some of the daily emotional stressors, the present study investigates a complementary experiential approach such as 'Emotional approach' or the tendency to affectively acknowledge, understand and express emotional experience (cf. Read More

    Destruction of noradrenergic terminals increases dopamine concentration and reduces dopamine metabolism in the medial prefrontal cortex.
    Behav Brain Res 2018 Feb 14. Epub 2018 Feb 14.
    Institute of Physiology, University of Pécs Medical School, Pécs, Hungary; Molecular Neuroendocrinology Research Group, University of Pécs, Szentágothai Research Center, Pécs, Hungary.
    Effects of destroyed noradrenergic (NE) innervation in the medial prefrontal cortex (mPFC) were examined on dopamine (DA) content and metabolism. 6-hydroxy-DOPA (6-OHDOPA) or 6-hydroxy-dopamine (6-OHDA) in combination with a potent DA reuptake inhibitor GBR 12935 or 6-OHDA were injected bilaterally into the mPFC in separate groups of animals. In addition, GBR 12935 or vehicle was injected into the mPFC in two other groups of animals as control experiments. Read More

    Predicting Cognitive Decline with Deep Learning of Brain Metabolism and Amyloid Imaging.
    Behav Brain Res 2018 Feb 14. Epub 2018 Feb 14.
    Biomedical Imaging Group, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. Electronic address:
    For effective treatment of Alzheimer's disease (AD), it is important to identify subjects who are most likely to exhibit rapid cognitive decline. We aimed to develop an automatic image interpretation system based on a deep convolutional neural network (CNN) which can accurately predict future cognitive decline in mild cognitive impairment (MCI) patients using flurodeoxyglucose and florbetapir positron emission tomography (PET). PET images of 139 patients with AD, 171 patients with MCI and 182 normal subjects obtained from Alzheimer's Disease Neuroimaging Initiative database were used. Read More

    Decompressive craniectomy protects against hippocampal edema and behavioral deficits at an early stage of a moderately controlled cortical impact brain injury model in adult male rats.
    Behav Brain Res 2018 Feb 13. Epub 2018 Feb 13.
    Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, PR China; China National Clinical Research Center for Neurological Diseases, Beijing 100050, PR China; Beijing Key Laboratory of Central Nervous System Injury, Beijing 100050, PR China; Neurotrauma Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, PR China; Nerve injury and repair center of Beijing Institute for Brain Disorders, Beijing 100050, PR China. Electronic address:
    A decompressive craniectomy (DC) has been shown to be a life-saving therapeutic treatment for traumatic brain injury (TBI) patients, which also might result in post-operative behavioral dysfunction. However, there is still no definite conclusion about whether the behavioral dysfunction already existed at an early stage after the DC operation or is just a long-term post-operation complication. Therefore, the aim of the present study was to analyze whether DC treatment was beneficial to behavioral function at an early stage post TBI. Read More

    Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice.
    Behav Brain Res 2018 Feb 13. Epub 2018 Feb 13.
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, 781032, Assam, India.
    Major depressive disorder (MDD) is a multifactorial neuropsychiatric disorder. Chronic administration of corticosterone (CORT) to rodents is used to mimic the stress associated dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, a well-established feature found in depressive patients. Recently, preclinical studies have demonstrated the antidepressant potential of histone deacetylase (HDAC) inhibitors. Read More

    Graded 6-OHDA-induced dopamine depletion in the nigrostriatal pathway evokes progressive pathological neuronal activities in the subthalamic nucleus of a hemi-parkinsonian mouse.
    Behav Brain Res 2018 Feb 13;344:42-47. Epub 2018 Feb 13.
    Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, South Korea; Department of Biomedical Engineering, Korea University of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, South Korea. Electronic address:
    Recent studies have established methods for establishing a rodent model that mimics progressive stages of human Parkinson's disease (PD), via injection of graded doses of 6-hydroxydopamine (6-OHDA) into regions within the nigrostriatal pathway. However, the electrophysiological characteristics of the subthalamic nucleus (STN) in this model have not been fully elucidated in this model. This study aimed to investigate changes in the neuronal activity of the STN in a graded mouse model of PD. Read More

    Environmental enrichment decreases avoidance responses in the elevated T-maze and delta FosB immunoreactivity in anxiety-related brain regions.
    Behav Brain Res 2018 Feb 12. Epub 2018 Feb 12.
    Departamento de Biociências, Universidade Federal de São Paulo (UNIFESP), Santos, SP, Brazil. Electronic address:
    Environmental enrichment (EE) is an animal management technique, which seems to improve adaptation to the experimental conditions of housing in laboratory animals. Previous studies have pointed to different beneficial effects of the procedure in the treatment of several disorders, including psychiatric conditions such as depression. The anxiolytic effects induced by EE, on the other hand, are not as clear. Read More

    Dendritic spine density and EphrinB2 levels of hippocampal and anterior cingulate cortex neurons increase sequentially during formation of recent and remote fear memory in the mouse.
    Behav Brain Res 2018 Feb 11. Epub 2018 Feb 11.
    Department of Psychology, University of Rome "Sapienza", via dei Marsi 78, 00185 Rome, Italy; Research Center in Neurobiology "Daniel Bovet" (CRiN), Rome, Italy. Electronic address:
    Memory consolidation is a dynamic process that involves a sequential remodeling of hippocampal-cortical circuits. Although synaptic events underlying memory consolidation are well assessed, fine molecular events controlling this process deserve further characterization. To this aim, we challenged male C57BL/6N mice in a contextual fear conditioning (CFC) paradigm and tested their memory 24 h, 7 days or 36 days later. Read More

    Different macaque models of cognitive aging exhibit task-dependent behavioral disparities.
    Behav Brain Res 2018 Feb 9. Epub 2018 Feb 9.
    Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, 85724, USA; Division of Neural Systems, Memory & Aging, University of Arizona, Tucson, AZ, 85724, USA; Department of Psychology, Neurology and Neuroscience, University of Arizona, Tucson, AZ, 85724, USA. Electronic address:
    Deficits in cognitive functions that rely on the integrity of the frontal and temporal lobes are characteristic of normative human aging. Due to similar aging phenotypes and homologous cortical organization between nonhuman primates and humans, several species of macaque monkeys are used as models to explore brain senescence. These macaque species are typically regarded as equivalent models of cognitive aging, yet no direct comparisons have been made to support this assumption. Read More

    The Impact of Natural Aging on Computational and Neural Indices of Perceptual Decision Making: A Review.
    Behav Brain Res 2018 Feb 9. Epub 2018 Feb 9.
    Trinity College Dublin Institute of Neuroscience and School of Psychology, Trinity College Dublin, Dublin 2, Ireland.
    It is well established that natural aging negatively impacts on a wide variety of cognitive functions and research has sought to identify core neural mechanisms that may account for these disparate changes. A central feature of any cognitive task is the requirement to translate sensory information into an appropriate action - a process commonly known as perceptual decision making. While computational, psychophysical, and neurophysiological research has made substantial progress in establishing the key computations and neural mechanisms underpinning decision making, it is only relatively recently that this knowledge has begun to be applied to research on aging. Read More

    Comparison between male and female rats in a model of self-administration of a chocolate-flavored beverage: Behavioral and neurochemical studies.
    Behav Brain Res 2018 Feb 7;344:28-41. Epub 2018 Feb 7.
    Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, SS 554, km 4,500, 09042 Monserrato, Cagliari, Italy; Neuroscience Institute, National Research Council of Italy, Section of Cagliari, SS 554, km 4,500, 09042 Monserrato, Cagliari, Italy.
    The existence of sex differences was studied in a rat model of operant self-administration of a chocolate-flavored beverage (CFB), which possesses strong reinforcing properties and is avidly consumed by rats. Whether these differences occurred concomitantly to changes in extracellular dopamine in the dialysate obtained from the nucleus accumbens, was assessed by intracerebral microdialysis. Male, ovariectomized and intact female rats showed similar self-administration profiles, with minor differences in both acquisition and maintenance phases. Read More

    The Visible Burrow System: A behavioral paradigm to assess sociability and social withdrawal in BTBR and C57BL/6J mice strains.
    Behav Brain Res 2018 Feb 7;344:9-19. Epub 2018 Feb 7.
    Groningen Institute for Evolutionary Life Science, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands. Electronic address:
    Disrupted sociability and consequent social withdrawal are (early) symptoms of a wide variety of neuropsychiatric diseases, such as schizophrenia, autism spectrum disorders, depressive disorders and Alzheimer's disease. The paucity of objective measures to translationally assess social withdrawal characteristics has been an important limitation to study this behavioral phenotype, both in human and rodents. The aim of the present study was to investigate sociability and social withdrawal in rodents using an ethologically valid behavioral paradigm, the Visible Burrow System (VBS). Read More

    Age and HIV effects on resting state of the brain in relationship to neurocognitive functioning.
    Behav Brain Res 2018 Feb 6;344:20-27. Epub 2018 Feb 6.
    The Faculty of Psychology, University of Warsaw, Stawki 5/7, 00-183 Warsaw, Poland.
    This study examined the effects of age and HIV infection on the resting state (RS) functional connectivity (FC) of the brain and cognitive functioning. The objective was to evaluate the moderating role of age and HIV on the relationship between RS-FC and cognition. To examine RS-FC we implemented the Independent Component Analysis (ICA) and Regional Homogeneity (ReHo). Read More

    Incorporation of new neurons in the olfactory bulb after paced mating in the female rat.
    Behav Brain Res 2018 Feb 6;343:95-101. Epub 2018 Feb 6.
    Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Blvd Juriquilla 3001, 76230. Electronic address:
    One of the regions that constantly produces neurogenesis in the adult brain is the subventricular zone (SVZ), whose new cells migrate to the olfactory bulbs (OB). When the females regulate the copulatory events (paced mating) the number of new cells in the SVZ increases, as well as those observed in the OB 15 days later. However, no changes were observed in the number of cells 45 days after the females paced the sexual interaction. Read More

    Genetically defined fear-induced aggression: Focus on BDNF and its receptors.
    Behav Brain Res 2018 Feb 6;343:102-110. Epub 2018 Feb 6.
    The Federal Research Center Institute of Cytology and Genetics, The Siberian Branch of Russian Academy of Sciences, Lavrentyeva av.10, Novosibirsk, 630090, Russia.
    Brain-derived neurotrophic factor (BDNF), its precursor proBDNF, BDNF pro-peptide, BDNF mRNA levels, as well as TrkB and p75receptors mRNA and protein levels, were studied in the brain of rats, selectively bred for more than 85 generations for either the high level or the lack of fear-induced aggressive behavior. Furthermore, we have found that rats of aggressive strain demonstrated both high level of aggression toward humans and increased amplitude of acoustic startle response compared to rats selectively bred for the lack of fear-induced aggression. Significant increase in the BDNF mRNA, mature BDNF and proBDNF protein levels in the raphe nuclei (RN), hippocampus (Hc), nucleus accumbens (NAcc), amygdala, striatum and hypothalamus (Ht) of aggressive rats was revealed. Read More

    Roles of the anterior basolateral amygdalar nucleus during exposure to a live predator and to a predator-associated context.
    Behav Brain Res 2018 Apr 4;342:51-56. Epub 2018 Feb 4.
    Dept. Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil. Electronic address:
    The basolateral amygdala complex, which includes the lateral, basolateral and basomedial nuclei, has been implicated in innate and contextual fear responses to predator threats. In the basolateral complex, the lateral and posterior basomedial nuclei are able to process predator odor information, and they project to the predator-responsive hypothalamic circuit; lesions in these amygdalar sites reduce innate responses and practically abolish contextual fear responses to predatory threats. In contrast to the lateral and posterior basomedial nuclei, the basolateral nucleus does not receive direct information from predator olfactory cues and has no direct link to the predator-responsive hypothalamic circuit. Read More

    Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats.
    Behav Brain Res 2018 Feb 5. Epub 2018 Feb 5.
    College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, PR China. Electronic address:
    In mammals, environmental factors including cold stress exert dramatic effects on adult health during late gestation, the cold stress response refers to an organism's response to cold. Indeed, cells and organs, including the hippocampus, are coordinated to respond to prevent hypothermia. The hippocampus act as an important brain structure that regulates the activity of the hypothalamic-pituitary-adrenal (HPA) axis, and suppress the stress reaction through feedback regulation of the HPA axis. Read More

    Development of novel tasks for studying view-invariant object recognition in rodents: Sensitivity to scopolamine.
    Behav Brain Res 2018 Feb 2;344:48-56. Epub 2018 Feb 2.
    Department of Psychology, University of Guelph, Canada; Collaborative Neuroscience Program, University of Guelph, Canada.
    The capacity to recognize objects from different view-points or angles, referred to as view-invariance, is an essential process that humans engage in daily. Currently, the ability to investigate the neurobiological underpinnings of this phenomenon is limited, as few ethologically valid view-invariant object recognition tasks exist for rodents. Here, we report two complementary, novel view-invariant object recognition tasks in which rodents physically interact with three-dimensional objects. Read More

    A daily single dose of a novel modafinil analogue CE-123 improves memory acquisition and memory retrieval.
    Behav Brain Res 2018 Feb 1;343:83-94. Epub 2018 Feb 1.
    Department of Neuroproteomics, Paracelsus Medical University, Salzburg, Austria. Electronic address:
    Dopamine reuptake inhibitors have been shown to improve cognitive parameters in various tasks and animal models. We recently reported a series of modafinil analogues, of which the most promising, 5-((benzhydrylsulfinyl)methyl) thiazole (CE-123), was selected for further development. The present study aims to characterize pharmacological properties of CE-123 and to investigate the potential to enhance memory performance in a rat model. Read More

    Pharmacological manipulation of GABA activity in nucleus subpretectalis/interstitio-pretecto-subpretectalis (SP/IPS) impairs figure-ground discrimination in pigeons: Running head: SP/IPS in figure-ground segregation.
    Behav Brain Res 2018 Feb 12;344:1-8. Epub 2018 Feb 12.
    Drake University, United States.
    Figure-ground segregation is a fundamental visual ability that allows an organism to separate an object from its background. Our earlier research has shown that nucleus rotundus (Rt), a thalamic nucleus processing visual information in pigeons, together with its inhibitory complex, nucleus subpretectalis/interstitio-pretecto-subpretectalis (SP/IPS), are critically involved in figure-ground discrimination (Acerbo et al., 2012; Scully et al. Read More

    Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein.
    Behav Brain Res 2018 Jan 31;343:41-49. Epub 2018 Jan 31.
    Department of Pharmaceutical Sciences and Center for Neurodegenerative Disease and Aging, Northeast Ohio Medical University, USA. Electronic address:
    Loss of function mutations in the gene ATP13A2 are associated with Kufor-Rakeb Syndrome and Neuronal Ceroid Lipofuscinosis, the former designated as an inherited form of Parkinson's disease (PD). The function of ATP13A2 is unclear but in vitro studies indicate it is a lysosomal protein and may interact with the presynaptic protein alpha-synuclein (aSyn) and certain heavy metals. Accumulation of aSyn is a major component of lewy bodies, the pathological hallmark of PD. Read More

    Nicotine-enhanced Pavlovian conditioned approach is resistant to omission of expected outcome.
    Behav Brain Res 2018 Jan 29;343:16-20. Epub 2018 Jan 29.
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA; Neuroscience Curriculum, University of North Carolina, Chapel Hill, NC, USA; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA. Electronic address:
    Conditioned stimuli contribute to the resilience of nicotine addiction in that nicotine-associated cues can influence smokers and promote relapse. These stimuli are thought to acquire incentive motivational properties through a Pavlovian mechanism, and this phenomenon can be measured in animals by observing conditioned approach to the conditioned stimulus (sign-tracking) or to the location of unconditioned stimulus delivery (goal-tracking). Goal-tracking is thought to be more flexible than sign-tracking in response to changes in expected outcome. Read More

    Chronic amphetamine treatment affects collicular-dependent behaviour.
    Behav Brain Res 2018 Jan 27;343:1-7. Epub 2018 Jan 27.
    School of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK7 6AA, UK; Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK. Electronic address:
    Distractibility can be defined as an attention deficit where orientation toward irrelevant targets cannot be inhibited. There is now mounting evidence that the superior colliculus is a key neural correlate of distractibility, with increased collicular-activity resulting in heightened distractibility. Heightened distractibility is reduced by amphetamine, which acutely suppresses collicular responsiveness. Read More

    Morphine antinociception on thermal sensitivity and place conditioning in male and female rats treated with intraplantar complete freund's adjuvant.
    Behav Brain Res 2018 Jan 30;343:21-27. Epub 2018 Jan 30.
    Department of Pharmaceutical Sciences, Western University of Health Sciences, 309 E. Second Street, Pomona, CA 91766, USA. Electronic address:
    The experience of pain is characterized by the presence of a noxious sensory stimulus combined with negative affect, which is often treated clinically through administration of drugs such as morphine or other opioids. This study investigated the effects of morphine one and seven days after intraplantar administration of complete freund's adjuvant (CFA) in male and female rats. Hargreaves test for thermal nociception and conditioned place preference (CPP) were performed following subcutaneous administration of saline or morphine (1. Read More

    NMDA receptors in the avian amygdala and the premotor arcopallium mediate distinct aspects of appetitive extinction learning.
    Behav Brain Res 2018 Jan 31;343:71-82. Epub 2018 Jan 31.
    Faculty for Psychology, Biopsychology, Institute for Cognitive Neuroscience, Ruhr University Bochum, Bochum, Germany.
    Extinction learning is an essential mechanism that enables constant adaptation to ever-changing environmental conditions. The underlying neural circuit is mostly studied with rodent models using auditory cued fear conditioning. In order to uncover the variant and the invariant neural properties of extinction learning, we adopted pigeons as an animal model in an appetitive sign-tracking paradigm. Read More

    Strategic neuronal encoding in medial prefrontal cortex of spatial working memory in the T-maze.
    Behav Brain Res 2018 Jan 31;343:50-60. Epub 2018 Jan 31.
    Department of Neurology, Penn State University College of Medicine, Hershey PA 17033 United States; Department of Pharmacology, Penn State University College of Medicine, Hershey PA 17033 United States. Electronic address:
    Strategic neuronal encoding in the medial prefrontal cortex (mPFC) of the rat was correlated with spatial working memory (sWM) assessed by behavior in the T-maze. Neurons increased their firing rate around choice, with the increase largely occurring before choice as a prospective encode of behavior. This could be classified as sensitive-to-spatial information or sensitive-to-choice outcome. Read More

    Glutamine/Glutamate (Glx) concentration in prefrontal cortex predicts reversal learning performance in the marmoset.
    Behav Brain Res 2018 Jan 26. Epub 2018 Jan 26.
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, United States.
    This study used Magnetic Resonance Spectroscopy (MRS) to identify potential neurometabolitic markers of cognitive performance in male (n =7) and female (n=8) middle-aged (~5 years old) common marmosets (Callithrix jacchus). Anesthetized marmosets were scanned with a 4.7 T/40cm horizontal magnet equipped with 450 mT/m magnetic field gradients and a 20-G/cm magnetic field gradient insert, within 3 months of completing the CANTAB serial Reversal Learning task. Read More

    Antidepressant administration modulates stress-induced DNA methylation and DNA methyltransferase expression in rat prefrontal cortex and hippocampus.
    Behav Brain Res 2018 Jan 29;343:8-15. Epub 2018 Jan 29.
    Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP, Brazil; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo, Brazil; Department of Clinical Medicine, Translational Neuropsychiatry Unit, Aarhus University, Aarhus, Denmark. Electronic address:
    Stress and antidepressant treatment can modulate DNA methylation in promoter region of genes related to neuroplasticity and mood regulation, thus implicating this epigenetic mechanism in depression neurobiology and treatment. Accordingly, systemic administration of DNA methyltransferase (DNMT) inhibitors induces antidepressant-like effects in rodents. DNA methylation is conveyed by DNMT 1, 3a and 3b isoforms, which are differentially expressed in the brain. Read More

    Food-induced reinforcement is abrogated by the genetic deletion of the MTor MTmelatonin receptor in C3H/HeN mice.
    Behav Brain Res 2018 Jan 31;343:28-35. Epub 2018 Jan 31.
    Department of Pharmacology & Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, United States. Electronic address:
    Palatable food is known for its ability to enhance reinforcing responses. Studies have suggested a circadian variation in both drug and natural reinforcement, with each following its own time course. The goal of this study was to determine the role of the MTand MTmelatonin receptors in palatable snack food-induced reinforcement, as measured by the conditioned place preference (CPP) paradigm during the light and dark phases. Read More

    Inequity aversion is observed in common marmosets but not in marmoset models of autism induced by prenatal exposure to valproic acid.
    Behav Brain Res 2018 Jan 31;343:36-40. Epub 2018 Jan 31.
    Graduate School of Information Science, Nagoya University, Japan; Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Japan. Electronic address:
    Humans and various nonhuman primates respond negatively to inequity not in their favor (i.e., inequity aversion), when inequity between two individuals is introduced. Read More

    Glycyrrhizic acid ameliorates the kynurenine pathway in association with its antidepressant effect.
    Behav Brain Res 2018 Jan 26. Epub 2018 Jan 26.
    Lab of Stress Medicine, Department of Psychology and Mental Health, Second Military Medical University, Shanghai 200433, China. Electronic address:
    Our previous study implied the role of central high mobility group box 1 (HMGB1) in lipopolysaccharide (LPS)-induced depressive-like behaviors that could partially abrogate by glycyrrhizic acid (GZA). Here, we considered the potential mechanism underlying GZA ameliorating chronic stress-induced depression both in vivo and in vitro. Depression model was established with the 4-week chronic unpredictable mild stress (CUMS) mice. Read More

    Intermittent intense exercise protects against cognitive decline in a similar manner to moderate exercise in chronically stressed mice.
    Behav Brain Res 2018 Jan 18. Epub 2018 Jan 18.
    Department of Health and Sports Science, Nippon Medical School, 1-7-1 Kyounan-cho, Musashino, Tokyo 180-0023, Japan. Electronic address:
    It is well known that regular low or mild exercise helps to improve and maintain cognition. On the other hand, ever thought many people prefer high-intensity exercise (e.g. Read More

    Anxiety-like behavior and neuropeptide receptor expression in male and female prairie voles: The effects of stress and social buffering.
    Behav Brain Res 2018 Apr 31;342:70-78. Epub 2018 Jan 31.
    Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL, 32306, USA. Electronic address:
    Strong social support can negate negative health outcomes - an effect defined as 'social buffering'. In the present study, using the socially monogamous prairie vole (Microtus ochrogaster), we examined whether the presence of a bonded partner during a stressful event can reduce stress responses. Adult, pair-bonded female and male voles were assigned into experimental groups that were either handled (Control), experienced a 1-h immobilization (IMO) stress alone (IMO-Alone), or experienced IMO with their partner (IMO-Partner). Read More

    Sex differences in rat decision-making: The confounding role of extraneous feeder sampling between trials.
    Behav Brain Res 2018 Apr 4;342:62-69. Epub 2018 Feb 4.
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive West, Lethbridge, AB, T1K 6T5, Canada. Electronic address:
    Although male and female rats appear to perform differently in some tasks, a clear picture of sex differences in decision-making has yet to develop. This is in part due to significant variability arising from differences in strains and tasks. The aim of this study was to characterize the effects of sex on specific response elements in a reinforcement learning task so as to help identify potential explanations for this variability. Read More

    A role for CA3 in social recognition memory.
    Behav Brain Res 2018 Feb 2. Epub 2018 Feb 2.
    Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan. Electronic address:
    Social recognition memory is crucial for survival across species, underlying the need to correctly identify conspecifics, mates and potential enemies. In humans the hippocampus is engaged in social and episodic memory, however the circuit mechanisms of social memory in rodent models has only recently come under scrutiny. Work in mice has established that the dorsal CA2 and ventral CA1 regions play critical roles, however a more comprehensive comparative analyses of the circuits and mechanisms required has not been reported. Read More

    Reversible inactivation of interpeduncular nucleus impairs memory consolidation and retrieval but not learning in rats: A behavioral and molecular study.
    Behav Brain Res 2018 Apr 31;342:79-88. Epub 2018 Jan 31.
    School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), P.O. Box 1954851167, Tehran, Iran; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, P.O. Box 19615-1178, Tehran, Iran. Electronic address:
    The Interpedundular nucleus (IPN) is a small midbrain structure located deeply between the two cerebral peduncles. The strategic placement of this nucleus makes it a possible relay between structures involved in the modulation of hippocampal theta rhythm activity. In this study we aimed to investigate how reversible inactivation of IPN could affect the acquisition, consolidation and retrieval phases of memory in passive avoidance (PA) and Morris water maze (MWM) tasks. Read More

    Food allergy induces alteration in brain inflammatory status and cognitive impairments.
    Behav Brain Res 2018 Jan 12. Epub 2018 Jan 12.
    Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, PR China; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, PR China; Brain Research Centre, University of British Columbia, Vancouver, BC, V6T 2B5, Canada. Electronic address:
    Accumulating evidence supports an increase in emotional and behavioral problems in patients with food allergy, but the underlying mechanism remains poorly understood. Here we found that in addition to inducing an increase of allergic factors in serum, food allergy also increased levels of antigen-specific immunoglobulins and mast cell marker in the brain. In particular, food allergy increased the number of total microglia and the percentage of active microglia in the cerebral cortex and hippocampal CA1 areas, and induced the increase of TNF-α in the cerebral cortex. Read More

    Effects of exercise and enrichment on behaviour in CD-1 mice.
    Behav Brain Res 2018 Apr 12;342:43-50. Epub 2018 Jan 12.
    Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, Ontario, Canada; Department of Psychiatry, St. Michael's Hospital, Toronto, Ontario, Canada. Electronic address:
    A host of scholarly work has characterized the positive effects of exercise and environmental enrichment on behaviour and cognition in animal studies. The purpose of this study was to investigate the uptake and longitudinal impact of exercise and enrichment on the behavioural phenotype of male and female CD-1 mice. CD-1 mice housed in standard (STD) or exercise and enrichment (EE) conditions post-weaning were tested in the 3-chamber sociability test, open field, and elevated plus maze and exercise activity was monitored throughout the enrichment protocol. Read More

    Genetic biomarkers for differential diagnosis of major depressive disorder and bipolar disorder: A systematic and critical review.
    Behav Brain Res 2018 Jan 11. Epub 2018 Jan 11.
    Stress and Affective Disorders (SAD) Programme, Department of Neurosciences and Behavior, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil; Centre for Affective Disorders, Psychological Medicine, King's College London, UK. Electronic address:
    Depressive symptoms are present in the depressive mood state of bipolar disorder (BPD) and major depression disorder (MDD). Often, in clinical practice, BPD patients are misdiagnosed with MDD. Therefore, genetic biomarkers could contribute to the improvement of differential diagnosis between BPD and MDD. Read More

    Recovery of stress-impaired social behavior by an antagonist of the CRF binding protein, CRFin the bed nucleus of the stria terminalis of male rats.
    Behav Brain Res 2018 Jan 9. Epub 2018 Jan 9.
    Instituto de Psicologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address:
    Social stress is recognized to promote the development of neuropsychiatric and mood disorders. Corticotropin releasing factor (CRF) is an important neuropeptide activated by social stress, and it contributes to neural and behavioral adaptations, as indicated by impaired social interactions and anhedonic effects. Few studies have focused on the role of the CRF binding protein (CRFBP), a component of the CRF system, and its activity in the bed nucleus of stria terminalis (BNST), a limbic structure connecting amygdala and hypothalamus. Read More

    Differential requirement of de novo Arc protein synthesis in the insular cortex and the amygdala for safe and aversive taste long-term memory formation.
    Behav Brain Res 2018 Apr 8;342:89-93. Epub 2018 Jan 8.
    Departamento de Neurociencias, Instituto de Fisiología Celular, Mexico.
    Several immediate early genes products are known to be involved in the facilitation of structural and functional modifications at distinct synapses activated through experience. The IEG-encoded protein Arc (activity regulated cytoskeletal-associated protein) has been widely implicated in long-term memory formation and stabilization. In this study, we sought to evaluate a possible role for de novo Arc protein synthesis in the insular cortex (IC) and in the amygdala (AMY) during long-term taste memory formation. Read More

    Sleep architecture is altered in the reserpine-induced fibromyalgia model in ovariectomized rats.
    Behav Brain Res 2018 Jan 8. Epub 2018 Jan 8.
    Department of Research in Neurosciences, National Institute of Psychiatry "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, Col. Sn Lorenzo Huipulco, 14370, D. F. México, Mexico. Electronic address:
    Fibromyalgia (FM) is a musculoskeletal chronic pain syndrome with various concomitant symptoms like sleep disorders. FM patients are mainly women and menopause might play an important role in the altered processing of somatosensory information. Adverse effects and moderated efficacy of drugs promote treatment discontinuation by patients. Read More

    Antidepressant effects of focused ultrasound induced blood-brain-barrier opening.
    Behav Brain Res 2018 Apr 8;342:57-61. Epub 2018 Jan 8.
    Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
    In many cases, hippocampal neurogenesis appears to be a hallmark of antidepressant treatments. One novel technique for inducing this type of neurogenesis is using focused ultrasound waves, in conjunction with circulating microbubbles, to open the blood-brain-barrier. The present experiment aimed to test whether this technique has antidepressant effects in a rodent model. Read More

    Cognitive decline and increased hippocampal p-tau expression in mice with hearing loss.
    Behav Brain Res 2018 Apr 6;342:19-26. Epub 2018 Jan 6.
    Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:
    Hearing and cognition are commonly involved in both normal and pathological aging. Current clinical interest lies in whether peripheral hearing loss promotes cognitive decline. In our previous publication, the authors have shown a causal relationship between hearing and cognitive impairments in C57BL/6 mice. Read More

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