11,683 results match your criteria Behavioural Brain Research [Journal]


Modulation of neuroplasticity-related targets following stress-induced acute escape deficit.

Behav Brain Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125, Modena, Italy; Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

Understanding resilience is a major challenge to improve current pharmacological therapies aimed at complementing psychological-based approaches of stress-related disorders. In particular, resilience is a multi-factorial construct where the complex network of molecular events that drive the process still needs to be resolved. Here, we exploit the Acute Escape Deficit model, an animal model based on exposure to acute unavoidable stress followed by an escape test, to define vulnerable and resilient phenotypes in rats. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.023DOI Listing
February 2019

Effects of Nicotinamide on Spatial Memory and Inflammation After Juvenile Traumatic Brain Injury.

Behav Brain Res 2019 Feb 13. Epub 2019 Feb 13.

Neurotrauma and Rehabilitation Laboratory, Southern Illinois University, Carbondale, IL, United States. Electronic address:

Age is a consistent predictor of outcome following traumatic brain injury (TBI). Although children and adolescents have the highest rate of hospitalizations and long-term disabilities, few preclinical studies have attempted to model and treat TBI in this population. Studies using nicotinamide (NAM), a soluble B-group vitamin, in older animals (3-6 months) have shown improved functional recovery in experimental models of TBI. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.024DOI Listing
February 2019

Integration and segregation of functional segmented anterior and posterior hippocampal networks in memory performance.

Behav Brain Res 2019 Feb 12. Epub 2019 Feb 12.

Radiology Department, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, China. Electronic address:

Purpose: To determine the association between functional connectivity (FC) of functional-segmented anterior and posterior portions of the hippocampus and performance on verbal and visual memory tests in a young, healthy population.

Methods: We recruited 100 healthy participants in the age of 19-29. Resting state fMRI data were acquired and voxel-wise correlation analysis was performed to functionally divide the hippocampus. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.019DOI Listing
February 2019

Probability discounting of monetary gains and losses in opioid-dependent adults.

Behav Brain Res 2019 Feb 12. Epub 2019 Feb 12.

Western Sydney University, Building 24, Bankstown Campus Office: 24.1.6 Locked Bag 1797, Penrith, NSW, 2751, Australia. Electronic address:

While the link between delay discounting and drug addiction has been well established, much less is known about probability discounting (PD) in the context of substance abuse. This study is the first to investigate how opioid-dependent individuals make risky decisions about gains and losses using the PD paradigm. Fifty-six opioid-dependent adults receiving opioid maintenance therapy and 55 controls performed two tasks that assessed PD of hypothetical monetary gains and losses, and completed the Barratt Impulsivity Scale (BIS-11). Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.017DOI Listing
February 2019

A new avenue for treating neuronal diseases: ceftriaxone, an old antibiotic demonstrating behavioral neuronal effects.

Behav Brain Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Psychology, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung 402, Taiwan, ROC. Electronic address:

Several neurodegenerative disorders, namely Parkinson's disease dementia, dementia with Lewy bodies, and Alzheimer's disease, share common pathophysiological features, such as (1) cognitive deficits, (2) glutamatergic hyperactivity-related excitotoxicity, and (3) deposition of α-synuclein (α-syn) and β-amyloid (Aβ). Ceftriaxone (CEF) is a well-tested and safe drug that has been used as an antibiotic for several decades. Recent studies have demonstrated the following effects of CEF: (1) increasing glutamate transporter-1 expression and glutamate reuptake and suppressing excitotoxicity, (2) binding well with α-syn and inhibition of α-syn polymerization, (3) modulating expression of genes related to Aβ metabolism, and (4) enhancing neurogenesis and recovery of neuronal density. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.020DOI Listing
February 2019

Latent toxoplasmosis aggravates anxiety- and depressive-like behaviour and suggest a role of gene-environment interactions in the behavioural response to the parasite.

Behav Brain Res 2019 Feb 12. Epub 2019 Feb 12.

Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, 8240 Risskov, Denmark; Department of Clinical Medicine, AUGUST Centre, Aarhus University, Risskov, Denmark.

Toxoplasma gondii (TOX) is an intracellular parasite which infects warm-blooded animals including humans. An increasing number of clinical studies now hypothesize that latent toxoplasmosis may be a risk factor for the development of psychiatric disease. For depression, the results have been varied and we speculate that genetic background is important for the response to latent toxoplasmosis. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.018DOI Listing
February 2019

The neurophysiological correlates of handedness: Insights from the lateralized readiness potential.

Behav Brain Res 2019 Feb 12. Epub 2019 Feb 12.

Biopsychology, Institute of Cognitive Neuroscience, Department of Psychology, Ruhr University, Bochum, Germany.

Handedness is the most investigated form of functional hemispheric asymmetries, but its neural correlates remain unclear. Functional imaging studies suggest differences between left- and right-handers in ipsilateral activation during unilateral hand movements, but do not allow for conclusions on the temporal dimension. In the Tapley and Bryden task, subjects have to draw as many dots as possible on a paper within 20 seconds using either the left or the right hand. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.021DOI Listing
February 2019

GABA/benzodiazepine receptors in the dorsal periaqueductal gray mediate the panicolytic but not the anxiolytic effect of alprazolam in rats.

Behav Brain Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto, Sao Paulo, Brazil. Electronic address:

Although the etiology of panic disorder (PD) remains elusive, accumulating evidence suggests a key role for the dorsal periaqueductal gray matter (dPAG). There is also evidence that this midbrain area is critically involved in mediation of the panicolytic effect of antidepressants, which with high potency benzodiazepines (e.g. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.016DOI Listing
February 2019

Ketamine improved depressive-like behaviors via hippocampal glucocorticoid receptor in chronic stress induced- susceptible mice.

Behav Brain Res 2019 Feb 10;364:75-84. Epub 2019 Feb 10.

Nanjing Medical University, Nanjing, Jiangsu, 211166, China; Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China. Electronic address:

Chronic stress is an important factor for depression. Most individuals recover from stress, while some develop into depression. The pathogenesis of resilience or susceptibility remains unclear. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.057DOI Listing
February 2019

Time-dependent protective effects of morphine against behavioral and morphological deficits in an animal model of posttraumatic stress disorder.

Behav Brain Res 2019 Feb 10;364:19-28. Epub 2019 Feb 10.

Laboratoryof Learning and Memory, Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran; Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. Electronic address:

Post-traumatic stress disorder (PTSD) arises after an individual has experienced a major traumatic event. Recent evidence suggests that acute morphine treatment may serve as a strategy to reduce PTSD development. In the present study, we investigated the time-dependent effects of morphine on behavioral and morphological deficits induced by the single prolonged stress (SPS), an experimental model of PTSD, in adult male rats. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.058DOI Listing
February 2019
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3.028 Impact Factor

Neuronostatin promotes soluble Aβ1-42 oligomers -induced spatial learning and memory impairments in mice.

Behav Brain Res 2019 Feb 10;364:62-74. Epub 2019 Feb 10.

College of Life Sciences, Northwest Normal University, Lanzhou, Gansu, 730070, China.

Neuronostatin (NST) is composed of a 13-amino acid and amidated peptide hormone encoded in the somatostatin (SST) gene, and plays an important physiological function in diverse tissues. Previous studies have shown that intracerebroventricular (i.c. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.047DOI Listing
February 2019

Hippocampus-specific Rictor knockdown inhibited 17β-estradiol induced neuronal plasticity and spatial memory improvement in ovariectomized mice.

Behav Brain Res 2019 Feb 10;364:50-61. Epub 2019 Feb 10.

Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing 400038, China. Electronic address:

Estrogens have been shown to play profound roles in the regulation of the structure and function of the hippocampus; however, the underlying mechanism is not clear. Previous studies have shown that when Rictor, the core component of the mammalian target of the rapamycin complex 2 (mTORC2), was deleted, hippocampal actin polymerization was reduced and long-term memory was seriously impaired. Although hippocampal Rictor could be regulated by estrogen receptor agonists/antagonists, whether Rictor could directly mediate estrogenic regulation of neuronal plasticity, spatial learning and memory remains unclear. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.014DOI Listing
February 2019

sIs hippocampal theta frequency related to individual and sex differences in anxiety-like behaviour? An analysis in male and female Long-Evans rats.

Behav Brain Res 2019 Feb 9. Epub 2019 Feb 9.

Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, K7L 3N6, Canada. Electronic address:

Hippocampal theta activity is a prominent slow (4-12 Hz) oscillatory activity pattern generated in the mammalian hippocampal formation. Based on evidence that anxiolytic drugs consistently decrease the frequency of hippocampal theta activity in rodents, hippocampal theta has been linked to anxiety states, leading to the influential theta suppression model of anxiolysis. Surprisingly, very few studies have examined whether hippocampal theta frequency relates to individual or sex differences in anxiety-like behaviour. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.056DOI Listing
February 2019

Social odour activates the hippocampal formation in zebra finches (Taeniopygia guttata).

Behav Brain Res 2019 Feb 7;364:41-49. Epub 2019 Feb 7.

Center for Mind/Brain Sciences, University of Trento, Piazza Manifattura 1, I-38068 Rovereto, Italy. Electronic address:

Experiments from our research group have demonstrated that the olfactory sense of birds, which has been considered as unimportant for a long time, plays a prominent role as communication channel in social behaviour. Odour cues are used e.g. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.013DOI Listing
February 2019

Genetic contribution of catechol-O-methyltransferase in dorsolateral prefrontal cortex functional changes in the first episode schizophrenia.

Behav Brain Res 2019 Feb 7. Epub 2019 Feb 7.

School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China; Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, Shaanxi, China; Institute of Automation, Chinese Academy of Sciences, Beijing, China. Electronic address:

Catechol-O-methyltransferase (COMT) gene variants have been reported to be implicated in the pathogenesis of psychotic symptoms in schizophrenia, especially in negative symptoms. These symptoms including apathy, blunted affect, social withdrawal and motor retardation. Neuroimaging studies suggested that negative symptoms appear to be associated with impaired activities of the prefrontal cortex in particular the dorsolateral prefrontal cortex (DLPFC). Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.012DOI Listing
February 2019
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3.028 Impact Factor

Coping with the forced swim stressor: current state-of-the-art.

Behav Brain Res 2019 Feb 6. Epub 2019 Feb 6.

Department of Endocrinology and Metabolic Disease, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

The forced swim test (FST) for rodents does not model despair or helplessness. It also is not a read-out for depression, anxiety, psychomotor retardation or autism, because these are anthropomorphic interpretations of the rodent's acquired immobility. Rather, the transition from swimming to immobility allows to examine the mechanistic underpinning of coping with inescapable stressors. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.005DOI Listing
February 2019
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Differential Gene Expression in the Mesocorticolimbic System of Innately High- and Low-Impulsive Rats.

Behav Brain Res 2019 Feb 6. Epub 2019 Feb 6.

Department of Anatomy & Neuroscience, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland. Electronic address:

Impulsivity is an important component of many psychiatric illnesses and has been associated with a number of psychiatric disorders such as bipolar disorder and attention deficit / hyperactivity disorder (ADHD). Exploring the different aspects of impulsive behaviour and assigning these to specific neurobiological pathways would advance our interpretation of disorders for which impulsivity is key. Pharmacological studies have implicated a number of neurotransmitters in impulsivity, which in turn have been shown to be affected by several genes in both rodent and human studies of impulsivity. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.022DOI Listing
February 2019
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Nitrergic signaling modulation by ascorbic acid treatment is responsible for anxiolysis in mouse model of anxiety.

Behav Brain Res 2019 Feb 6;364:85-98. Epub 2019 Feb 6.

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, Haryana, India. Electronic address:

The present study was designed to investigate the effect of ascorbic acid (AA) treatment on the anxiety related behavioral and neurochemical alterations. AA (50, 100 and 200 mg/kg, i.p. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.007DOI Listing
February 2019

Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression.

Behav Brain Res 2019 Feb 6. Epub 2019 Feb 6.

Saarland University Hospital, Department of Clinical Chemistry and Laboratory Medicine, Building 57, D-66421 Homburg, Saar, Germany; Aarhus Institute of Advanced Studies, Aarhus University, DK-8000 Aarhus C, Denmark.

Depression is associated with dysregulation of methyl group metabolism such as low S-adenosylmethionine (SAM). We previously reported that Flinders Sensitive Line (FSL) rats, an animal model of depression, had lower concentrations of liver SAM than the control rats, Flinders Resistant Line (FRL) rats. The present study investigated if SAM supplementation may correct liver SAM and behavioral abnormalities in this model. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.011DOI Listing
February 2019

Type 1 diabetes and working memory processing of emotional faces.

Behav Brain Res 2019 Feb 6;363:173-181. Epub 2019 Feb 6.

Instituto de Neurociencias, Universidad de Guadalajara, Mexico.

Several executive functions decline with the development of type-1 diabetes (T1D), particularly working memory (WM). In adults, WM ensures efficient cognitive processing by focusing on task-relevant information while suppressing distractors. It has been well documented that WM can be influenced by emotional stimuli, which may facilitate the retention of information, interfere with uptake, or even affect its capacity. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.008DOI Listing
February 2019

Prediction of Causal Genes and Gene Expression Analysis of Attention-Deficit Hyperactivity Disorder in the Different Brain Region, a Comprehensive Integrative Analysis of ADHD.

Behav Brain Res 2019 Feb 6. Epub 2019 Feb 6.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University, Shanghai, 200030, China; The Affiliated Hospital of Qingdao University, The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, 266003, China. Electronic address:

Recent genome-wide association study (GWAS) identified 12 independent loci for Attention-deficit hyperactivity disorder (ADHD). However, the causal genes expression and pathways of ADHD is still vague. We integrated GWAS, eQTL and genes expression data to find the causal genes, genes expression, and genes prioritization in the different brain tissues and whole blood cells. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.010DOI Listing
February 2019
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Impact of early exposure to a cafeteria diet on prefrontal cortex monoamines and novel object recognition in adolescent rats.

Behav Brain Res 2019 Feb 5;363:191-198. Epub 2019 Feb 5.

School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK. Electronic address:

The prefrontal cortex (PFC) undergoes protracted postnatal development such that its structure and behavioural function may be profoundly altered by environmental factors. Here we investigate the effect of lactational dietary manipulations on novel object recognition (NOR) learning and PFC monoamine neurotransmitter metabolism in early adolescent rats. To this end, Wistar rat dams were fed a high caloric cafeteria diet (CD) during lactation and resultant 24-26 day old offspring exposed to NOR testing and simultaneous PFC dopamine and serotonin metabolism measurement. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.003DOI Listing
February 2019

Neurobehavioral effects of chronic low-dose risperidone administration in juvenile male rats.

Behav Brain Res 2019 Feb 5;363:155-160. Epub 2019 Feb 5.

Department of Psychology, Sociology, and Social Work, West Texas A&M University, Canyon, TX, USA. Electronic address:

Despite substantial increases in the use of antipsychotics to treat various psychiatric conditions in children, there is a lack of literature regarding long-term effects of early treatment. Some studies have indicated that early administration results in differential alterations to neurotransmission systems, but few studies have investigated whether there are long-term behavioral modifications. Therefore, the aim of the current study was to investigate the neurobehavioral effects of low dose risperidone (a commonly prescribed antipsychotic) treatment using juvenile rats. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.009DOI Listing
February 2019

PINK1 deficiency is associated with increased deficits of adult hippocampal neurogenesis and lowers the threshold for stress-induced depression in mice.

Behav Brain Res 2019 Feb 5;363:161-172. Epub 2019 Feb 5.

School of Life Science and Technology, Harbin Institute of Technology, 150080 Harbin, China. Electronic address:

Parkinson's disease (PD) is characterized by motor impairments and several non-motor features, including frequent depression and anxiety. Stress-induced deficits of adult hippocampal neurogenesis (AHN) have been linked with abnormal affective behavior in animals. It has been speculated that AHN defects may contribute to affective symptoms in PD, but this hypothesis remains insufficiently tested in animal models. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.006DOI Listing
February 2019

Serotonin type 6 receptor antagonist attenuates the impairment of long-term potentiation and memory induced by Abeta.

Behav Brain Res 2019 Feb 5. Epub 2019 Feb 5.

Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Alzheimer's disease (AD) is the most common cause of dementia, characterized by memory impairment and synaptic loss. Long-term potentiation (LTP), a type of synaptic plasticity, is impaired during AD. Serotonin type 6 receptor (5-HT6R) inactivation is proposed as a therapeutic target for AD. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.004DOI Listing
February 2019

Function of complement factor H and imaging of small molecules by MALDI-MSI in a methamphetamine behavioral sensitization model.

Behav Brain Res 2019 Feb 4. Epub 2019 Feb 4.

State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China; Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address:

Background: At present, the harm of new-type drug, methamphetamine (METH), has gradually exceeded that of the traditional opioid drugs, and METH abuse has become a serious public health and social problem. In our previous study, complement factor H (CFH) was found to be upregulated in the sera of METH-addicted patients and rats and in certain brain regions in the rats.

Methods: We used ELISA and immunofluorescence to confirm the changes in CFH in the serum and hippocampus of a METH behavioral sensitization mouse model, and C1q expression was also detected by immunofluorescence in the hippocampus. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.002DOI Listing
February 2019
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Early postnatal environmental enrichment restores neurochemical and functional plasticities of the cerebral cortex and improves learning performance in hidden-prenatally-malnourished young-adult rats.

Behav Brain Res 2019 Feb 2;363:182-190. Epub 2019 Feb 2.

School of Medicine, Faculty of Medical Sciences, University of Santiago de Chile, Santiago, Chile. Electronic address:

Moderate reduction of dietary protein (from 25% to 8% casein) in pregnant rats, calorically compensated by carbohydrates, gives rise to 'hidden prenatal malnutrition' (HPM) in the offspring since it does not alter body and brain weights of pups at birth. However, this dietary treatment leads to decreased β-adrenoceptor signaling and brain derived neurotrophic factor (BDNF) levels in the pup' brain, altogether with defective cortical long-term potentiation (LTP) and lowered visuospatial memory performance. Since early postnatal environmental enrichment (EE) has been shown to exert plastic effects on the developing brain and neuroprotection both on cognition and on structural properties of the neocortex, in the present study we addressed the question of whether early postnatal EE during the lactation period could exert compensatory changes in the expression of ®-adrenergic receptors and BDNF in the neocortex of HPM rats, and if these effects are associated with an improvement or even a restore of both neocortical LTP in vivo and cognitive performance induced by HPM. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.001DOI Listing
February 2019
2 Reads

Attenuation of hyperhomocysteinemia induced vascular dementia by sodium orthovanadate perhaps via PTP1B: Pertinent downstream outcomes.

Behav Brain Res 2019 Feb 2;364:29-40. Epub 2019 Feb 2.

Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, India. Electronic address:

Vascular dementia (VaD) is the second most common form of dementia after Alzheimer's disease, but drug regulatory authorities have not approved any effective medication for this indication. Researchers are keenly aware of the need to uncover precise and druggable targets for VaD. However, finding such a target is an experimentally impractical and challenging task, owing to the highly complex interplay between cognitive and functional abilities of the brain with a diversity of vascular diseases that usually results from various underlying risk factors. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.039DOI Listing
February 2019
1 Read
3.028 Impact Factor

Swimming exercise decreases the absence-like epileptic activity in WAG/Rij rats.

Behav Brain Res 2019 Feb 1;363:145-148. Epub 2019 Feb 1.

Department of Physiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.

Aim: The aim of the present study was to evaluate the effects of long (60 min/day), moderate (30 min/day) and short (15 min/day) term daily swimming exercise programs for 90 days on durations and the spike-wave discharges (SWDs) seen in the electrocorticographic (ECoG) recordings of WAG/Rij rats with absence epilepsy.

Materials And Methods: Thirty-five adult male rats were divided into 5 groups as; Group 1: Control, Group 2: Sham (daily exposed to shallow water), Group 3: 15 min/day swimming exercise, Group 4: 30 min/day swimming exercise, Group 5: 60 min/day swimming exercise. After 90 days of swimming exercise program; ECoG recordings were taken for 2 h. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.060DOI Listing
February 2019
4 Reads

Ablation of NMDA receptors in dopamine neurons disrupts attribution of incentive salience to reward-paired stimuli.

Behav Brain Res 2019 Jan 31;363:77-82. Epub 2019 Jan 31.

Department of Molecular Neuropharmacology, Institute of Pharmacology of the Polish Academy of Sciences, Smętna 12, 31-343, Krakow, Poland. Electronic address:

Midbrain dopamine (DA) neurons play a crucial role in the formation of conditioned associations between environmental cues and appetitive events. Activation of N-methyl-d-aspartate (NMDA) receptors is a key mechanism responsible for the generation of conditioned responses of DA neurons to reward cues. Here, we tested the effects of the cell type-specific inactivation of NMDA receptors in DA neurons in adult mice on stimulus-reward learning. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.037DOI Listing
January 2019

DNA methylation of the Tacr2 gene in a CUMS model of depression.

Behav Brain Res 2019 Jan 31. Epub 2019 Jan 31.

Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, 430060, PR China; Institute of Neuropsychiatry, Renmin Hospital, Wuhan University, 430060, Wuhan, China. Electronic address:

Tacr2, the gene encoding the NK2 receptor, belongs to G protein-coupled receptors. Accumulating evidence has indicated that the tachykinin receptors may contribute to the pathophysiology of depression. During the last decade, some studies have shown that Tacr2 activation is involved in the modulation of emotional processes. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.059DOI Listing
January 2019

The effects of bullying in depression on white matter integrity.

Behav Brain Res 2019 Jan 30;363:149-154. Epub 2019 Jan 30.

Stanford University, United States.

Individuals with elevated symptoms of depression exhibit alterations in white matter integrity, including lower fractional anisotropy (FA) evident on diffusion tensor imaging (DTI). Similarly, individuals with a history of early life stress (ELS) exhibit lower FA in the white matter independent of concurrent depression. Prior studies have not determined whether the neuroimaging signature of comorbid ELS and adult depression differs from the pattern of brain white matter changes associated with depression in the absence of self-reported ELS. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.054DOI Listing
January 2019
3.028 Impact Factor

More rapid reversal learning following overtraining in the rat is evidence that behavioural and cognitive flexibility are dissociable.

Behav Brain Res 2019 Jan 30;363:45-52. Epub 2019 Jan 30.

School of Psychology & Neuroscience, University of St Andrews, St Mary's Quad, South Street, St Andrews, KY16 9JP, UK. Electronic address:

Cognitive flexibility is a term used to describe the brain processes underlying the phenomenon of adaptive change in behaviour in response to changed contingencies in the internal or external environment. Cognitive flexibility is often assessed in complex tasks measuring perceptual attentional shifting or response or task switching, but, arguably, reversal learning is a simple assay of cognitive flexibility. Reversal learning requires the detection of a changed outcome, the cessation of a previously-rewarded response and the selection of an alternative, previously-unrewarded, response. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.055DOI Listing
January 2019

Effect of aging on choice-induced cognitive conflict.

Behav Brain Res 2019 Jan 30;363:94-102. Epub 2019 Jan 30.

Kansei Fukushi Research Institute, Tohoku Fukushi University, Japan.

When individuals are forced to choose between similarly preferable alternatives, a negatively arousing cognitive conflict occurs, and the preference attitudes toward the chosen and rejected alternatives diverge. This phenomenon, often referred to as "cognitive dissonance", is of interest in psychological and decision neuroscience research. The dorsal anterior cingulate cortex (dACC) is involved in representing the cognitive conflict induced by difficult-choice tasks. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.053DOI Listing
January 2019
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Stress response genes associated with attention deficit hyperactivity disorder: A case-control study in Chinese children.

Behav Brain Res 2019 Jan 29;363:126-134. Epub 2019 Jan 29.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

To explore the associations between stress response genes and attention deficit hyperactivity disorder (ADHD) in children, we conducted a case-control study consisting of 406 newly diagnosed ADHD cases and 432 controls in Wuhan, China. We genotyped the candidate genes, nuclear receptor subfamily 3 group C member 1(NR3C1) and solute carrier family 6 member 4(SLC6A4), using the Sequenom MassARRAY technology. After correction by Bonferroni (α' = 0. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.051DOI Listing
January 2019
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3.028 Impact Factor

The Role of the Deeper Layers of the Superior Colliculus in Attentional Modulations of Prepulse Inhibition.

Behav Brain Res 2019 Jan 29. Epub 2019 Jan 29.

School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Speech and Hearing Research Center, Key Laboratory on Machine Perception (Ministry of Education), Peking University, Beijing 100080, China; Beijing Institute for Brain Disorders, Beijing, China. Electronic address:

Prepulse inhibition (PPI) is the suppression of the startle reflex, when a weaker non-startling sensory stimulus (the prepulse) precedes the intense startling stimulus. Although the basic PPI neural circuitry resides in the brainstem, PPI can be enhanced by selective attention to the prepulse, indicating that this sensorimotor-gating process is influenced by higher-order perceptual/cognitive processes. Along with the auditory cortex, the brain structures involved in attentional modulations of PPI include both the lateral nucleus of the amygdala (LA), which contributes to the fear-conditioning modulation, and the posterior parietal cortex (PPC), which contributes to the spatially attentional modulation. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.052DOI Listing
January 2019

Influence of sex and hormonal status on initial impact and neurocognitive outcome after subarachnoid haemorrhage in rats.

Behav Brain Res 2019 Jan 28;363:13-22. Epub 2019 Jan 28.

Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Anaesthesiology and Intensive Care Medicine, Ismaninger Str. 22, 81675 München, Germany.

The aim of this study was to detect differences in functional outcome after experimental subarachnoid haemorrhage (SAH) in rodents with different hormonal status. For this purpose, the endovascular perforation model was applied to four groups of Sprague-Dawley-Rats: male intact, male neutered, female intact and female neutered animals. Initial impact was measured by ICP, CPP and cerebral blood flow in the first hour after SAH. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.050DOI Listing
January 2019
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Minocycline ameliorates anxiety-related self-grooming behaviors and alters hippocampal neuroinflammation, GABA and serum cholesterol levels in female Sprague-Dawley rats subjected to chronic unpredictable mild stress.

Behav Brain Res 2019 Jan 28;363:109-117. Epub 2019 Jan 28.

Research Institute for Marine Drug & Nutrition, College of Food Science & Technology, Guangdong Ocean University, Zhanjiang, China; Marine Medicine Development Center, Shenzhen Institute, Guangdong Ocean University, Shenzhen, Guangdong, China. Electronic address:

Neuroinflammation induced by stress results in aberrant neurotransmission and dyslipidemia, which can trigger depression- and anxiety-like behaviors. Gamma-aminobutyric acid (GABA) and cholesterol play a crucial role in anxiety-like states, including self-grooming - a common stress-evoked rodent behavior. However, the interaction between neuroinflammation, GABA and cholesterol under stress, and their effects on grooming, remain unclear. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.045DOI Listing
January 2019

Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats.

Behav Brain Res 2019 Jan 28;363:30-37. Epub 2019 Jan 28.

Institute of Military Cognition and Brain Sciences, Beijing, China; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China. Electronic address:

Metformin, an antidiabetic biguanide, reduces hyperglycemia by improving glucose utilization and reducing gluconeogenesis. Recently, an increasing number of studies have shown that metformin also led to a significant clinical improvement in memory and cognition in different clinical settings. In the present study, we investigated whether metformin administration protects against memory impairment and neuron damage caused by acute exposure to hypobaric hypoxia and screened the possible molecular mechanisms with a focused gene array. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328183141
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http://dx.doi.org/10.1016/j.bbr.2019.01.048DOI Listing
January 2019
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3.028 Impact Factor

Long lasting behavioural effects on cuprizone fed mice after neurotoxicant withdrawal.

Behav Brain Res 2019 Jan 28;363:38-44. Epub 2019 Jan 28.

Dept. of Psychology, Universitat Rovira i Virgili, Tarragona, Spain; Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, Tarragona, Spain; Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, Tarragona, Spain; Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, Tarragona, Spain.

Destruction of the myelin sheath in the central nervous system (CNS) is prominent in many clinico-pathologic conditions. Among animal models that reproduce the pathological features of de- and remyelination processes, the mouse model of cuprizone administration is widely used. Both hyperactivity and motor impairment have been reported upon cuprizone exposure. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.036DOI Listing
January 2019
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Wheel-running exercise before and during gestation against acute and sensitized cocaine psychomotor-activation in offspring.

Behav Brain Res 2019 Jan 28;363:53-60. Epub 2019 Jan 28.

Université de Liège, Département de Psychologie, Quartier Agora - Place des orateurs, 2 (B32), 4000 Liège, Belgium.

While animal research has consistently reported preventive effects of exercise against drug abuse vulnerability, little is known about the influence of the developmental stage during which exercise is displayed on addictive drugs responsiveness. This study aimed to determine whether prenatal exercise could attenuate acute cocaine reactivity and psychomotor sensitization in youth offspring. We used a split-plot factorial design where C57BL/6 J females were randomly assigned into sedentary or exercised (wheel-running) conditions before and during gestation, the wheels being removed on gestational day 18. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328183117
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http://dx.doi.org/10.1016/j.bbr.2019.01.049DOI Listing
January 2019
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Associations between brain structure and perceived intensity of sweet and bitter tastes.

Behav Brain Res 2019 Jan 28;363:103-108. Epub 2019 Jan 28.

Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia; Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.

Functional neuroimaging studies have identified brain regions associated with human taste perception, but only a few have investigated the associations with brain structure. Here, in this exploratory study, we examined the association between the volumes of 82 regions of interest (ROI) and the perceived intensities of sweet (a weighted mean rating of glucose, fructose, aspartame, neohesperidin dihydrochalcone) and bitter (propylthiouracil, quinine, caffeine) substances in a large Australian healthy cohort from the Queensland Twin IMaging (QTIM, n = 559) study and the perceived intensity of quinine in a large U.S. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328183157
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http://dx.doi.org/10.1016/j.bbr.2019.01.046DOI Listing
January 2019
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Impaired conflict monitoring in cognitive decline.

Behav Brain Res 2019 Jan 26;363:70-76. Epub 2019 Jan 26.

Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Neurology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan. Electronic address:

Resolving conflicts is an important cognitive ability of executive function, and it may decrease with cognitive decline. The flanker task is a practical test used to assess the ability to suppress responses that are inappropriate in a particular context. The aims of the present study were to investigate conflict monitoring of cognitive control in subjects with different levels of cognitive impairment, and clarify the usefulness of the flanker task in screening cognitive decline. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01664328183028
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http://dx.doi.org/10.1016/j.bbr.2019.01.043DOI Listing
January 2019
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Intracerebral injection of R-(-)-Apomorphine into the nucleus accumbens decreased carbachol-induced 22-kHz ultrasonic vocalizations in rats.

Behav Brain Res 2019 Jan 25. Epub 2019 Jan 25.

Departments of Biological Sciences Brock University, St. Catharines, Ontario, Canada; Psychology Brock University, St. Catharines, Ontario, Canada.

Rats can produce ultrasonic vocalizations (USVs) in a variety of different contexts that signal their emotional state to conspecifics. Under distress, rats can emit 22-kHz USVs, while during positive pro-social interactions rats can emit frequency-modulated (FM) 50-kHz USVs. It has been previously reported that rats with increasing emission of FM 50-kHz USVs in anticipation of rewarding electrical stimulation or positive pro-social interaction decrease the number of emitted 22-kHz USVs. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.044DOI Listing
January 2019

Sex differences in the progressive model of parkinsonism induced by reserpine in rats.

Behav Brain Res 2019 Jan 25;363:23-29. Epub 2019 Jan 25.

Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Behavioral and Evolutionary Neurobiology Laboratory, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil. Electronic address:

Parkinson's disease (PD) exhibits sexual differences in susceptibility and pathogenesis in humans, with a high incidence in men and a high severity of motor symptoms in male rodents. Furthermore, studies showed that the administration of low dose of reserpine (RES) induces a progressive appearance of motor alterations similar with parkinsonism in male rodents. Here, we investigated sex differences in motor deficits and tyrosine hydroxylase (TH) immunoreactivity induced by a progressive model of parkinsonism. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.041DOI Listing
January 2019

Anorexia increases microglial density and cytokine expression in the hippocampus of young female rats.

Behav Brain Res 2019 Jan 25;363:118-125. Epub 2019 Jan 25.

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Boulevard Juriquilla 3001, Juriquilla, Querétaro, CP76230, Mexico. Electronic address:

Anorexia by osmotic dehydration is an adaptive response to hypernatremia and hyperosmolaemia induced by ingestion of a hypertonic solution. Dehydration-induced anorexia (DIA) reproduces weight loss and avoidance of food, despite its availability. By using this model, we previously showed increased reactive astrocyte density in the rat dorsal hippocampus, suggesting a pro-inflammatory environment where microglia may play an important role. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.042DOI Listing
January 2019
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Cannabidiol modulates phosphorylated rpS6 signalling in a zebrafish model of Tuberous Sclerosis Complex.

Behav Brain Res 2019 Jan 23;363:135-144. Epub 2019 Jan 23.

School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK. Electronic address:

Tuberous sclerosis complex (TSC) is a rare disease caused by mutations in the TSC1 or TSC2 genes and is characterized by widespread tumour growth, intractable epilepsy, cognitive deficits and autistic behaviour. CBD has been reported to decrease seizures and inhibit tumour cell progression, therefore we sought to determine the influence of CBD on TSC pathology in zebrafish carrying a nonsense mutation in the tsc2 gene. CBD treatment from 6 to 7 days post-fertilization (dpf) induced significant anxiolytic actions without causing sedation. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.040DOI Listing
January 2019
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Abnormal empathy-like pro-social behaviour in the valproic acid model of autism spectrum disorder.

Behav Brain Res 2019 Jan 22;364:11-18. Epub 2019 Jan 22.

Translational Research Group in Autism Spectrum Disorders-GETTEA, Universidade Federal do Rio Grande do Sul (UFRGS), Ramiro Barcelos street, 2600, 90035-003, Porto Alegre, RS, Brazil; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Brasil avenue, 4365, Manguinhos, 21045-900, Rio de Janeiro, RJ, Brazil; School of Pharmacy and Biomedical Sciences, University of Central Lancashire, PR1 2HE, Lancashire, Preston, England, UK. Electronic address:

Impairments in social behaviour are a defining feature of autism spectrum disorder (ASD). Individuals with ASD also usually present some difficulty to recognize or understand another person's feelings. Therefore, it is possible that altered empathy processing could hinder typical social interaction in ASD. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.034DOI Listing
January 2019

Effects of chronic cocaine exposure on the circadian rhythmic expression of the clock genes in reward-related brain areas in rats.

Behav Brain Res 2019 Jan 22;363:61-69. Epub 2019 Jan 22.

Department of Psychiatry, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, 646000, China. Electronic address:

Drug addiction is a widespread social problem, which not only brings adverse consequences to the human body, but also causes great burden to the society. However, it's still unclear how the long-term and sustained cocaine exposure will affect clock genes' expression in the reward related brain areas. We hypothesize that chronic cocaine exposure causes changes in the circadian rhythmic expression of clock genes in brain regions associated with reward, since previous studies have shown that cocaine use causes circadian disorders. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.035DOI Listing
January 2019
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The effects of early exposure to MK-801 during environmental enrichment on spatial memory, methamphetamine self-administration and cue-induced renewal in rats.

Behav Brain Res 2019 Jan 21;363:83-93. Epub 2019 Jan 21.

Ningbo University School of Medicine, 818 Fenghua Road, Ningbo, Zhejiang, 315211, PR China. Electronic address:

Objective: Accumulating evidence indicates an association between improved cognition and the early introduction of environmental enrichment (EE). The beneficial effect of EE has also been examined in the field of methamphetamine (METH) dependence. The present study was designed to examine whether early cognitive alterations by dizocilpine (MK-801) in adolescence can impact the effect of EE on spatial memory, METH self-administration (SA), and cue-induced renewal in adulthood. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.032DOI Listing
January 2019
1 Read