Behav Brain Res 2017 Sep 16. Epub 2017 Sep 16.
Department of Pharmacology, University of Washington, Seattle, WA, 98195, United States; Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA, 98195, United States. Electronic address:
Huntington's Disease (HD) is an autosomal dominant neurodegenerative disease characterized by gradual deterioration of motor and cognitive functions and development of psychiatric deficits. Animal models provide powerful means to study the pathological processes, molecular dysfunctions and symptoms associated with HD. We performed a longitudinal behavioral study of the newly developed HdhQ350/+ mouse line, a knock-in model that expresses a repeat of 350 glutamines. Read More