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    11061 results match your criteria Behavioural Brain Research [Journal]

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    Relevance-dependent modulation of tactile suppression during active, passive and pantomime reach-to-grasp movements.
    Behav Brain Res 2017 Nov 18. Epub 2017 Nov 18.
    School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:
    When we move, our ability to detect tactile events on the moving limb is reduced (e.g., movement-related tactile suppression). Read More

    Inhibition of AMPAR endocytosis alleviates pentobarbital-induced spatial memory deficits and synaptic depression.
    Behav Brain Res 2017 Nov 18. Epub 2017 Nov 18.
    Ministry of Education Key Laboratory of Child Development and Disorders and Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. Electronic address:
    Our previous study has shown that pentobarbital causes memory deficits and impairs hippocampal synaptic plasticity. The Tat-GluA23Y peptide (GluA23Y) prevents activity-dependent α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) endocytosis. It enables early-phase long-term potentiation (LTP) to proceed to late-phase LTP allowing short-term memory to convert to long-term memory. Read More

    Contribution of M1 and M2 muscarinic receptor subtypes to convulsions in fasted mice treated with scopolamine and given food.
    Behav Brain Res 2017 Nov 17. Epub 2017 Nov 17.
    Department of Medical Pharmacology, Istanbul Faculty of Medicine, Istanbul University, Turkey. Electronic address:
    Treatment of fasted mice and rats with the nonselective muscarinic antagonist, scopolamine or atropine, causes convulsions after food intake. This study evaluated the effect of fasting on the expression of M1 and M2 muscarinic receptors in the brain regions, the relationship between receptor expression and seizure stages, and the muscarinic receptor subtype which plays a role in the occurrence of convulsions. Mice were grouped as allowed to eat ad lib (fed) and deprived of food for 24hours (fasted). Read More

    Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APP(NL-G-F) mice before prominent plaque deposition.
    Behav Brain Res 2017 Nov 17. Epub 2017 Nov 17.
    Laboratory of Biological Psychology, University of Leuven, KU Leuven, Belgium. Electronic address:
    Amyloid-β (Aβ) peptides occur in the brains of patients with Alzheimer's disease (AD), but their role in functional impairment is still debated. High levels of APP and APP fragments in mice that overexpress APP might confound their use in preclinical research. We examined the occurrence of behavioral, cognitive and neuroimaging changes in APP(NL-G-F) knock-in mice that display Aβ42 amyloidosis in the absence of APP overexpression. Read More

    Brain-Derived Neurotrophic Factor (BDNF) Determines a Sex Difference in Cue-conditioned Alcohol Seeking in Rats.
    Behav Brain Res 2017 Nov 17. Epub 2017 Nov 17.
    School of Life Sciences, Department of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, Australia.
    Alcohol use disorder is a detrimental addictive disease that develops through prolonged ethanol exposure and regular intoxication. However, the changes in the underlying neurobiology leading to alcohol addiction remain unclear. Brain-Derived Neurotrophic Factor (BDNF) is implicated in substance abuse disorders including alcoholism. Read More

    Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link.
    Behav Brain Res 2017 Nov 17. Epub 2017 Nov 17.
    Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Guizhou, China. Electronic address:
    It is well known that Alzheimer's disease (AD) is closely related to diabetes mellitus (DM), and AD is also regarded as Type 3 diabetes (T3D). However, the exact link between AD and DM is still unclear. Recently, more and more evidence has shown that glycogen synthase kinase-3β (GSK-3β) may be the potential link between DM and AD. Read More

    Effects of genetic and environmental risk for schizophrenia on hippocampal activity and psychosis-like behavior in mice.
    Behav Brain Res 2017 Nov 15. Epub 2017 Nov 15.
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas TX, 75390-9127, United States.
    Schizophrenia is a serious mental illness most notably characterized by psychotic symptoms. In humans, psychotic disorders are associated with specific hippocampal pathology. However, animal model systems for psychosis often lack this pathology, and have been weak in providing a representation of psychosis. Read More

    Facilitated acquisition of the classically conditioned eyeblink response in active duty military expressing posttraumatic stress disorder symptoms.
    Behav Brain Res 2017 Nov 14. Epub 2017 Nov 14.
    Department of Veterans Affairs, Syracuse Veterans Affairs Medical Center, Syracuse, NY, USA; Rutgers Biomedical Health Sciences, Department of Pharmacology, Physiology, and Neuroscience, Rutgers University, Newark, NJ, USA. Electronic address:
    Objective: Learning diathesis models underscore the role of hyper-conditioning in the development of PTSD following trauma exposure. Eyeblink classical conditioning is one method of examining associative learning biases independent of fear and threat produced by trauma. Facilitated learning is apparent in individuals self-expressing PTSD symptoms, as well as behaviorally inhibited (BI) temperament, a vulnerability factor for PTSD. Read More

    Nucleus accumbens core lesions induce sub-optimal choice and reduce sensitivity to magnitude and delay in impulsive choice tasks.
    Behav Brain Res 2017 Nov 13;339:28-38. Epub 2017 Nov 13.
    Department of Psychological Sciences, Kansas State University, Manhattan, KS 66506, USA. Electronic address:
    The nucleus accumbens core (NAc) has long been recognized as an important contributor to the computation of reward value that is critical for impulsive choice behavior. Impulsive choice refers to choosing a smaller-sooner (SS) over a larger-later (LL) reward when the LL is more optimal in terms of the rate of reward delivery. Two experiments examined the role of the NAc in impulsive choice and its component processes of delay and magnitude processing. Read More

    Distinct environmental enrichment protocols reduce anxiety but differentially modulate pain sensitivity in rats.
    Behav Brain Res 2017 Nov 11. Epub 2017 Nov 11.
    Laboratório Especial de Dor e Sinalização, Instituto Butantan, São Paulo, SP, Brazil. Electronic address:
    Environmental enrichment (EE) can alter anxiety as well as perception of nociceptive stimuli, suggesting a relationship between well-being and analgesia. Considering that, we aimed to evaluate the influence of different EE types on anxiety and peripheral pain sensibility of male Wistar rats. Animals were submitted to two different types of EE: On the first one, animals were housed in standard size cages after weaning and received three different objects, one type per week, on a regular basis (simple EE - sEE). Read More

    The effects of local microinjection of selective dopamine D1 and D2 receptor agonists and antagonists into the dorsal raphe nucleus on sleep and wakefulness in the rat.
    Behav Brain Res 2017 Nov 11;339:11-18. Epub 2017 Nov 11.
    Department of Pharmacology and Therapeutics, School of Medicine Clinics Hospital, University of the Republic, Montevideo 11600, Uruguay.
    The effects of the dopamine (DA) D1 and D2 receptor agonists SKF38393, bromocriptine and quinpirole, respectively, on spontaneous sleep were analyzed in adult rats prepared for chronic sleep recordings. Local administration of the DAergic agonists into the dorsal raphe nucleus (DRN) during the light phase of the light-dark cycle induced a significant reduction of rapid-eye movement sleep (REMS) and the number of REM periods. Additionally, bromocriptine and quinpirole significantly increased wakefulness (W). Read More

    Inhibition of leukotriene B4 synthesis protects against early brain injury possibly via reducing the neutrophil-generated inflammatory response and oxidative stress after subarachnoid hemorrhage in rats.
    Behav Brain Res 2017 Nov 11;339:19-27. Epub 2017 Nov 11.
    Department of Neurosurgery, The Affiliated Drum Tower Hospital of Nanjing University, Nanjing, Jiangsu Province, China. Electronic address:
    Leukotriene B4 (LTB4) is a highly potent neutrophil chemoattractant and neutrophils induces inflammatory response and oxidative stress when they recruit to and infiltrate in the injuried/inflamed site, such as the brain parenchyma after aneurysmal subarachnoid hemorrhage (SAH). This study is to investigate the potential effects of inhibition of LTB4 synthesis on neutrophil recruitment, inflammatory response and oxidative stress, as well as early brain injury (EBI) in rats after SAH. A pre-chiasmatic cistern SAH model of rats was used in this experiment. Read More

    Cocaine and desipramine elicit distinct striatal noradrenergic and behavioral responses in selectively bred obesity-resistant and obesity-prone rats.
    Behav Brain Res 2017 Nov 9. Epub 2017 Nov 9.
    Departments of Pharmacology and Chemistry University of Michigan, Ann Arbor, MI, USA. Electronic address:
    Previous studies have demonstrated a role for norepinephrine (NE) in energy regulation and feeding, and basal differences have been observed in hypothalamic NE systems in obesity-prone vs. obesity-resistant rats. Differences in the function of brain reward circuits, including in the nucleus accumbens (NAc), have been shown in obesity-prone vs. Read More

    Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the σ1 receptor.
    Behav Brain Res 2017 Nov 9;339:1-10. Epub 2017 Nov 9.
    MMDN, Univ. Montpellier, EPHE, INSERM, UMR-S1198, Montpellier, F-34095, France.
    The sigma-1 receptor (S1R) is a molecular chaperone which activity modulates several intracellular signals including calcium mobilization at mitochondria-associated endoplasmic reticulum membranes. S1R agonists are potent neuroprotectants against neurodegenerative insults and particularly in rodent models of Alzheimer's disease (AD). We here analyzed whether S1R inactivation modifies vulnerability to amyloid toxicity in AD models. Read More

    REM sleep deprivation and dopaminergic D2 receptors modulation increase recognition memory in an animal model of Parkinson's disease.
    Behav Brain Res 2017 Nov 8. Epub 2017 Nov 8.
    Laboratório de Neurofisiologia, Departamento de Fisiologia, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba, Brazil.
    Cognitive impairment is an important non-motor symptom of Parkinson's disease (PD). The neuronal death in nigrostriatal pathway is the main factor for motor symptoms and recent studies indicate a possible influence in non-motor symptoms as well. The pedunculopontine tegmental nucleus (PPT) and basal ganglia are closely related anatomically and functionally and, since they are affected by neurodegeneration in PD, they might be involved in recognition memory. Read More

    Adrenergic Manipulation Inhibits Pavlovian Conditioned Approach Behaviors.
    Behav Brain Res 2017 Nov 8. Epub 2017 Nov 8.
    SUNY University at Buffalo, Department of Psychology, United States.
    Environmental rewards and Pavlovian reward cues can acquire incentive salience, thereby eliciting incentive motivational states and instigate reward-seeking. In rats, the incentive salience of food cues can be measured during a Pavlovian conditioned approach paradigm, in which rats engage in cue-directed approach ("sign-tracking") or approach the food delivery location ("goal-tracking"). While it has been shown that dopamine signaling is necessary for sign-tracking, some studies have suggested that norepinephrine is involved in learning to sign-track as well. Read More

    Docosahexaenoic acid (DHA) enhances the therapeutic potential of neonatal neural stem cell transplantation post-Traumatic brain injury.
    Behav Brain Res 2017 Nov 7. Epub 2017 Nov 7.
    Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon, Lebanon; Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research, University of Florida, Gainesville, FL, USA. Electronic address:
    Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide with 1.5 million people inflicted yearly. Several neurotherapeutic interventions have been proposed including drug administration as well as cellular therapy involving neural stem cells (NSCs). Read More

    Phytochemical allylguaiacol exerts a neuroprotective effect on hippocampal cells and ameliorates scopolamine-induced memory impairment in mice.
    Behav Brain Res 2017 Nov 8. Epub 2017 Nov 8.
    Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea; Korean Medicine of Life Science, University of Science & Technology, Daejeon 34113, Republic of Korea. Electronic address:
    Allylguaiacol is a phytochemical occurring in various plants such as cloves, cinnamon, basil, and nutmeg. Pharmacological effects of allylguaiacol include antimicrobial, anti-inflammatory, anticancer, antioxidant, and neuroprotective activity. Although allylguaiacol is considered to have neuroprotective effects, there is no report on its regulatory mechanisms at the molecular level. Read More

    White matter integrity mediates decline in age-related inhibitory control.
    Behav Brain Res 2017 Nov 7. Epub 2017 Nov 7.
    Cognitive Neuroscience Division, Department of Neurology, Columbia University Medical Center, 630 W168th Street, P&S Box 16, New York, NY 10032, United States. Electronic address:
    Previous DTI studies have reported associations between white matter integrity and performance on the Stroop interference task. The current study aimed to add to these studies of inhibitory control by investigating how the differences in age and in white matter integrity relate to Stroop performance, and to examine whether the effect of age on Stroop performance is mediated by white matter integrity. 179 healthy adults from 20 to 80 years old were recruited in the study. Read More

    Effect of single doses of pindolol and d-fenfluramine on flumazenil-induced anxiety in panic disorder patients.
    Behav Brain Res 2017 Nov 4. Epub 2017 Nov 4.
    Institute of Neuroscience and Behavior (INeC), Ribeirao Preto, SP, Brazil.
    The effects of the 5-HT1A receptor blocker pindolol and the 5-HT releasing and uptake blocking agent d-fenfluramine, both used as indirect serotonin agonists, on flumazenil-induced acute anxiety reactions were studied in panic disorder patients to test the hypothesis that serotonin (5-HT) inhibits neural systems mediating panic attacks. Thirty never treated or drug free PD patients (16 females) aged 22-49 y (mean±SD, 32.9±8) received single doses of d-fenfluramine (n=10; 30mg, p. Read More

    Glucose metabolic alterations in hippocampus of diabetes mellitus rats and the regulation of aerobic exercise.
    Behav Brain Res 2017 Nov 4. Epub 2017 Nov 4.
    Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, No 399 Changhai Road, Yangpu District, Shanghai 200438, China. Electronic address:
    Diabetes could negatively affect the structures and functions of the brain, especially could cause the hippocampal dysfunction, however, the potential metabolic mechanism is unclear. The aim of this study was to investigate the changes of glucose metabolism in hippocampus of diabetes mellitus rats and the regulation of aerobic exercise, and to analyze the possible mechanisms. A rat model of type 2 diabetes mellitus was established by high-fat diet feeding in combination with STZ intraperitoneal injection, then 4 weeks of aerobic exercise was conducted. Read More

    Neuroanatomical correlates of time perspective: A voxel-based morphometry study.
    Behav Brain Res 2017 Nov 4. Epub 2017 Nov 4.
    School of Psychology, Southwest University, Chongqing, China; Key Laboratory of Cognition and Personality, Ministry of Education, China. Electronic address:
    Previous studies indicated that time perspective can affect many behaviors, such as decisions, risk taking, substance abuse and health behaviors. However, very little is known about the neural substrates of time perspective (TP). To address this question, we characterized different dimensions of TP (including the Past, Present, and Future TP) using standardized Zimbardo Time Perspective Inventory (ZTPI), and quantified the gray matter volume using voxel-based morphometry (VBM) method across two independent samples. Read More

    Assessment of sexual behavior in rats: The potentials and pitfalls.
    Behav Brain Res 2017 Oct 27. Epub 2017 Oct 27.
    Department of Psychology, UiT The Arctic University of Norway, Huginbakken 32, 9037 Tromso, Norway. Electronic address:
    In the field of behavioral neuroscience, it is essential to use the appropriate animal models for the topic of investigation. Using the wrong model can result in false interpretation of the results. In this review we will discuss the animal models used to study sexual behavior, with a focus on rats. Read More

    Characterization of oromotor and limb motor dysfunction in the DJ1 -/- model of Parkinson disease.
    Behav Brain Res 2017 Nov 3;339:47-56. Epub 2017 Nov 3.
    Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, 53706, USA; Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI, 53706, USA; Department of Surgery, Division of Otolaryngology, University of Wisconsin-Madison, Madison, WI, 53706, USA. Electronic address:
    Parkinson disease (PD) is devastating to sensorimotor function that includes cranial/oromotor and limb motor deficits. However, the onset, progression, and neural correlates of PD-related dysfunctions are poorly understood. To address this gap, we used a genetic rat model of PD, DJ1 -/-, and hypothesized that motor deficits would manifest early in the disease process, be progressive in nature, and be related to pathologies in brainstem structures associated with sensorimotor function. Read More

    Nonspatial sequence coding varies along the CA1 transverse axis.
    Behav Brain Res 2017 Oct 28. Epub 2017 Oct 28.
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA. Electronic address:
    The hippocampus plays a critical role in the memory for sequences of events, a defining feature of episodic memory. To shed light on the fundamental mechanisms supporting this capacity, we recently recorded neural activity in CA1 as rats performed a nonspatial odor sequence memory task. Our main finding was that, while the animals' location and behavior remained constant, a proportion of CA1 neurons fired differentially to odors depending on whether they were presented in or out of sequence (sequence cells). Read More

    The enduring impact of neurulation stage alcohol exposure: A combined behavioral and structural neuroimaging study in adult male and female C57BL/6J mice.
    Behav Brain Res 2018 Feb 28;338:173-184. Epub 2017 Oct 28.
    The Bowles Center for Alcohol Studies (EWF, LAW, SEP), Department of Cell Biology and Physiology (SEP), Department of Psychiatry (AR, SSM), and Carolina Institute for Developmental Disabilities (SSM, SEP), University of North Carolina, Chapel Hill, NC 27599, United States.
    Prenatal alcohol exposure (PAE) can cause behavioral and brain alterations over the lifespan. In animal models, these effects can occur following PAE confined to critical developmental periods, equivalent to the third and fourth weeks of human gestation, before pregnancy is usually recognized. The current study focuses on PAE during early neurulation and examines the behavioral and brain structural consequences that appear in adulthood. Read More

    Error Blindness and Motivational Significance: Shifts in Networks Centering on Anterior Insula Co-Vary with Error Awareness and Pupil Dilation.
    Behav Brain Res 2017 Oct 26. Epub 2017 Oct 26.
    Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands; Amsterdam Brain & Cognition (ABC), University of Amsterdam, The Netherlands. Electronic address:
    This investigation aims to further our understanding of the brain mechanisms underlying the awareness of one's erroneous actions. While all errors are registered as such in the rostral cingulate zone, errors enter awareness only when the anterior insula cortex is activated. Aware but not unaware errors elicit autonomic nervous system reactivity. Read More

    Behav Brain Res 2017 Nov 2. Epub 2017 Nov 2.
    Dept. Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil. Electronic address:
    The ventral part of the anteromedial thalamic nucleus (AMv) is heavily targeted by the dorsal premammillary nucleus (PMd), which is the main hypothalamic site that is responsive to both predator and conspecific aggressor threats. This PMd-AMv pathway is likely involved in modulating memory processing, and previous findings from our group have shown that cytotoxic lesions or pharmacological inactivation of the AMv drastically reduced contextual fear responses to predator-associated environments. In the present study, we investigated the role of the AMv in both unconditioned (i. Read More

    Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer's disease.
    Behav Brain Res 2017 Nov 2. Epub 2017 Nov 2.
    Basic Medical College, Zhengzhou University, Zhengzhou, Henan, China; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD,USA.
    Mesenchymal stem cell transplantation is a promising therapeutic approach for Alzheimer's disease (AD). However, poor engraftment and limited survival rates are major obstacles for its clinical application. Resveratrol, an activator of silent information regulator 2, homolog 1 (SIRT1), regulates cell destiny and is beneficial for neurodegenerative disorders. Read More

    Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice.
    Behav Brain Res 2017 Nov 2. Epub 2017 Nov 2.
    Laboratory of Behavioural Neurobiology, ETH Zurich, Schorenstrasse 16, CH-8603, Schwerzenbach, Switzerland; Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong. Electronic address:
    The water maze is one of the most widely employed spatial learning paradigms in the cognitive profiling of genetically modified mice. Oftentimes, tests of reference memory (RM) and working memory (WM) in the water maze are sequentially evaluated in the same animals. However, critical difference in the rules governing efficient escape from the water between WM and RM tests is expected to promote the adoption of incompatible mnemonic or navigational strategies. Read More

    Hippocampal gene expression patterns in oxytocin male knockout mice are related to impaired social interaction.
    Behav Brain Res 2017 Nov 2. Epub 2017 Nov 2.
    Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil; Programa de Pós-Graduação em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil. Electronic address:
    Social interaction between animals is crucial for the survival and life in groups. It is well demonstrated that oxytocin (OT) and vasopressin (AVP) play critical roles in the regulation of social behaviors in mammals, however, other neurotransmitters and hormones are involved in the brain circuitry related to these behaviors. The present study aimed to investigate the gene expression of neurotransmitter receptors in the brain of OT knockout (OTKO) male mice. Read More

    Stereotaxy in rat models: Current state of the art, proposals to improve targeting accuracy and reporting guideline.
    Behav Brain Res 2017 Nov 1. Epub 2017 Nov 1.
    Department of Neurosurgery, University Hospitals Leuven, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of Neuroscience, Laboratory for Experimental Neurosurgery and Neuroanatomy, University Hospitals Leuven, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address:
    Background: Stereotaxy is frequently employed in rodent models for precise brain injections or implantations. We intended to map the current practice in rat stereotaxy and list proposals to improve targeting accuracy.

    Methods: We selected 235 publications on rat stereotaxy from the last 5 years. Read More

    Two-day fasting evokes stress, but does not affect mood, brain activity, cognitive, psychomotor, and motor performance in overweight women.
    Behav Brain Res 2018 Feb 31;338:166-172. Epub 2017 Oct 31.
    Institute of Sports Science and Innovations, Lithuanian Sports University, Sporto str. 6, Kaunas, Lithuania.
    The physiological, cognitive state, and motor behavior changes that occur during acute fasting are not completely understood. Thus, the aim of this study was to estimate the effect of 2-day total fasting on evoked stress, mood, brain activity, and cognitive, psychomotor, and motor function in overweight women. Eleven overweight women (body mass index above 25kg/m(2)) aged 20-30 years were tested under two conditions allocated randomly: 2-day zero-calorie diet with water provided ad libitum and 2-day usual diet. Read More

    Amygdaloid involvement in the defensive behavior of mice exposed to the open elevated plus-maze.
    Behav Brain Res 2018 Feb 2;338:159-165. Epub 2017 Nov 2.
    Joint Graduate Program in Physiological Sciences, UFSCar/UNESP, São Carlos, SP, 13565-905, Brazil; Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences, Univ. Estadual Paulista, UNESP, 14800-903, Araraquara, SP, Brazil. Electronic address:
    Previous studies have shown that the exposure to an open elevated plus maze (oEPM, an EPM with all four open arms) elicits fear/anxiety-related responses in laboratory rodents. However, very little is known about the underlying neural substrates of these defensive behaviors. Accordingly, the present study investigated the effects of chemical inactivation of the amygdala [through local injection of cobalt chloride (CoCl2: a nonspecific synaptic blocker)] on the behavior of oEPM-exposed mice. Read More

    Activation of CRF/CRFR1 signaling in the basolateral nucleus of the amygdala contributes to chronic forced swim-induced depressive-like behaviors in rats.
    Behav Brain Res 2018 Feb 1;338:134-142. Epub 2017 Nov 1.
    Neuroscience Research Institute, Peking University and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China; The Second Affiliated Hospital of Xinxiang Medical University, Henan, China; Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Beijing, 100191, China. Electronic address:
    The basolateral nucleus of the amygdala (BLA) plays a key role in processing stressful events and affective disorders. Previously we have documented that exposure of chronic forced swim (FS) to rats produces a depressive-like behavior and that sensitization of BLA neurons is involved in this process. In the present study, we demonstrated that chronic FS stress (CFSS) could activate corticotropin-releasing factor (CRF)/CRF receptor type 1 (CRFR1) signaling in the BLA, and blockade of CRF/CRFR1 signaling by intra-BLA injection of NBI27914 (NBI), a selective CRFR1 antagonist, could prevent the CFSS-induced depressive-like behaviors in rats, indicating that activation of CRF/CRFR1 signaling in the BLA is required for CFSS-induced depression. Read More

    Lesions within the head direction system reduce retrosplenial c-fos expression but do not impair performance on a radial-arm maze task.
    Behav Brain Res 2018 Feb 25;338:153-158. Epub 2017 Oct 25.
    School of Psychology, Cardiff University, 70 Park Place, Cardiff, CF10 3AT, UK. Electronic address:
    The lateral mammillary nuclei are a central structure within the head direction system yet there is still relatively little known about how these nuclei contribute to spatial performance. In the present study, rats with selective neurotoxic lesions of the lateral mammillary nuclei were tested on a working memory task in a radial-arm maze. This task requires animals to distinguish between eight radially-oriented arms and remember which arms they have entered within a session. Read More

    Positive reinforcement modulates fronto-limbic systems subserving emotional interference in adolescents.
    Behav Brain Res 2018 Feb 24;338:109-117. Epub 2017 Oct 24.
    Department of Psychiatry, School of Medicine, University of Pittsburgh, 3811 O'Hara St., Pittsburgh, PA 15213, United States.
    Fronto-limbic systems play an important role in supporting resistance to emotional distraction to promote goal-directed behavior. Despite evidence that alterations in the functioning of these systems are implicated in developmental trajectories of psychopathology, most studies have been conducted in adults. This study examined the functioning of fronto-limbic systems subserving emotional interference in adolescents and whether differential reinforcement of correct responding can modulate these neural systems in ways that could promote resistance to emotional distraction. Read More

    Are rodent models of Parkinson's disease behaving as they should?
    Behav Brain Res 2017 Oct 24. Epub 2017 Oct 24.
    Oxford Parkinson's Disease Centre, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.
    In recent years our understanding of Parkinson's disease has expanded both in terms of pathological hallmarks as well as relevant genetic influences. In parallel with the aetiological discoveries a multitude of PD animal models have been established. The vast majority of these are rodent models based on environmental, genetic and mechanistic insight. Read More

    Speech perception in autism spectrum disorder: An activation likelihood estimation meta-analysis.
    Behav Brain Res 2018 Feb 23;338:118-127. Epub 2017 Oct 23.
    International Laboratory for Brain, Music, and Sound Research (BRAMS), Pavillon 1420 Mont-Royal, Department of Psychology, University of Montreal, C.P. 6128, Succ. Centre-Ville, Montreal, Quebec, H3C 3J7, Canada; Faculty of Medicine, McIntyre Medical Building, McGill University, 3655 Sir William Osler, Montreal, Quebec H3G 1Y6, Canada.
    Autism spectrum disorder (ASD) is often characterized by atypical language profiles and auditory and speech processing. These can contribute to aberrant language and social communication skills in ASD. The study of the neural basis of speech perception in ASD can serve as a potential neurobiological marker of ASD early on, but mixed results across studies renders it difficult to find a reliable neural characterization of speech processing in ASD. Read More

    Corrigendum to "Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors" [Behav. Brain Res. 332 (2017) 172-179].
    Behav Brain Res 2018 Feb 22;338:186-189. Epub 2017 Oct 22.
    Laboratory of Genetic Neuropharmacology, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA.

    Adaptive coordination of working-memory and reinforcement learning in non-human primates performing a trial-and-error problem solving task.
    Behav Brain Res 2017 Oct 20. Epub 2017 Oct 20.
    Sorbonne Universités, UPMC Univ Paris 06, CNRS, Institute of Intelligent Systems and Robotics (ISIR), F-75005 Paris, France.
    Accumulating evidence suggest that human behavior in trial-and-error learning tasks based on decisions between discrete actions may involve a combination of reinforcement learning (RL) and working-memory (WM). While the understanding of brain activity at stake in this type of tasks often involve the comparison with non-human primate neurophysiological results, it is not clear whether monkeys use similar combined RL and WM processes to solve these tasks. Here we analyzed the behavior of five monkeys with computational models combining RL and WM. Read More

    Principal component analysis and neural predictors of emotion regulation.
    Behav Brain Res 2018 Feb 20;338:128-133. Epub 2017 Oct 20.
    Department of Psychology (JMF), University of Wisconsin - Milwaukee, Milwaukee, WI, United States.
    Reappraisal, a cognitive approach intended to alter an emotional response, is generally associated with prefrontal cortical recruitment and decreased limbic activity. However, the extent to which neurofunctional activity predicts successful reappraisal is unclear. During fMRI, 60 healthy participants completed a reappraisal paradigm, which included reappraising negative images to reduce emotional reactivity ('ReappNeg') and viewing negative images and experiencing the negative affect they evoke ('LookNeg'). Read More

    Modified single prolonged stress reduces cocaine self-administration during acquisition regardless of rearing environment.
    Behav Brain Res 2018 Feb 20;338:143-152. Epub 2017 Oct 20.
    Department of Psychology, University of Kentucky, Lexington, KY, 40536, USA.
    Until recently, there were few rodent models available to study the interaction of post-traumatic stress disorder (PTSD) and drug taking. Like PTSD, single prolonged stress (SPS) produces hypothalamic-pituitary-adrenal (HPA) axis dysfunction and alters psychostimulant self-administration. Other stressors, such as isolation stress, also alter psychostimulant self-administration. Read More

    US alone trials presented during acquisition do not disrupt classical eyeblink conditioning: Empirical and computational findings.
    Behav Brain Res 2018 Feb 18;338:101-108. Epub 2017 Oct 18.
    Rutgers Biomedical Health Sciences, Stress and Motivated Behavior Institute, Rutgers University, Newark, NJ, United States; Department of Veterans Affairs, Syracuse Veterans Affairs Medical Center, Syracuse, NY, United States; Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, NY, United States.
    Studies of partial reinforcement in eyeblink conditioning have typically shown slower learning of a CS-US association when paired CS-US trials are interleaved with CS-alone trials. However, recent work has shown that CS-US learning is not slowed by interleaved US-alone trials. This discrepancy is surprising since both partial reinforcement protocols reduce the total number of paired CS-US trials. Read More

    Animals, anxiety, and anxiety disorders: How to measure anxiety in rodents and why.
    Behav Brain Res 2017 Oct 16. Epub 2017 Oct 16.
    Division of Neuropsychopharmacology, Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Ravila 14A Chemicum, 50411, Tartu, Estonia. Electronic address:
    Measurement of anxiety is desirable for the benefit of drug development and understanding the brain function and mental well-being. Animal models offer the advantages of detailed neurobiological analysis, experimental manipulation of specific components in the brain circuits that underlie psychopathology, and the possibility of screening novel drugs with clinical potential. A large variety of animal models of anxiety and screening tests of anxiolytics is currently in use. Read More

    Selective inhibition of distracting input.
    Behav Brain Res 2017 Oct 16. Epub 2017 Oct 16.
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, United Kingdom; Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, OX3 7JX, United Kingdom.
    We review a series of studies exploring distractor suppression. It is often assumed that preparatory distractor suppression is controlled via top-down mechanisms of attention akin to those that prepare brain areas for target enhancement. Here, we consider two alternative mechanisms: secondary inhibition and expectation suppression within a predictive coding framework. Read More

    Head-turning asymmetry: A novel lateralization in rats predicts susceptibility to behavioral despair.
    Behav Brain Res 2018 Feb 16;338:47-50. Epub 2017 Oct 16.
    Psychobiology Laboratory, Department of Psychology, Bogazici University, Istanbul 34342, Turkey.
    Behavioral markers of laterality reflecting underlying neurobiological asymmetries between the cerebral hemispheres are related to differential susceptibility to mood disorders. In the present study, we investigated the strength and consistency of a novel behavioral lateralization, head-turning asymmetry, and its relation to behavioral despair in adult female Wistar rats. Head-turning biases were determined in a test where water-deprived rats had to turn their head to right or left to gain access to a water dispenser. Read More

    Unilateral forelimb sensorimotor cortex devascularization disrupts the topographic and kinematic characteristics of hand movements while string-pulling for food in the rat.
    Behav Brain Res 2018 Feb 14;338:88-100. Epub 2017 Oct 14.
    Psychology Department, Northern Illinois University, De Kalb, Illinois, USA. Electronic address:
    String-pulling by the rat is a bimanual act, in which an upright animal retrieves a piece of food attached to the end of the string by downward hand-over-hand movements. The present study compared the movements of string-pulling, using topographic and kinematic measures of hand movement, in control rats and rats with unilateral sensorimotor motor cortex lesion produced by removal of the pia matter. In the first week following devascularization, the rhythmicity and accuracy of string-pulling movements decomposed; however, thereafter the rhythm of bilateral alternation was restored. Read More

    Effects of pharmacological manipulation of the kappa opioid receptors on the aversive effects of nicotine.
    Behav Brain Res 2018 Feb 14;338:56-65. Epub 2017 Oct 14.
    Department of Pharmaceutical and Biomedical Sciences, The Raabe College of Pharmacy, Ohio Northern University, 525 S Main Street, Ada, OH 45810, United States. Electronic address:
    Nicotine, an addictive component of tobacco smoke, produces both rewarding and aversive effects. Increasing the aversive effects of nicotine may help in promoting smoking cessation. However, neural targets mediating the aversive effects of nicotine have not been fully identified. Read More

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