2,525,615 results match your criteria Behavioral medicine Washington D.C.[Journal]


[Peripheral Nerve Imaging - from a Neurological Perspective for Surgeons].

Zentralbl Chir 2020 Jul 2. Epub 2020 Jul 2.

Klinik für Neurologie, Städtisches Klinikum Dessau, Deutschland.

Nerve ultrasound is a fairly new non-invasive method to visualise peripheral nerves and to detect peripheral nerve lesions. This technique can depict nerve compression syndromes and their aetiologies as well as fascicular torsions. It is also suitable for sonographically guided nerve interventions and for intraoperative navigation. Read More

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http://dx.doi.org/10.1055/a-1189-3627DOI Listing

Lifetime Psychosocial Stress Exposure Associated with Hypertensive Disorders of Pregnancy.

Am J Perinatol 2020 Jul 2. Epub 2020 Jul 2.

Department of Obstetrics and Gynecology, NorthShore University Health System, Center for Healthcare Studies, Institute for Public Health and Medicine, University of Chicago Pritzker School of Medicine, Northwestern University, Evanston, Illinois.

Objective:  Hypertensive disorders of pregnancy (HDP) complicate 5 to 10% of all pregnancies and are a major cause of pregnancy-related morbidity. Exposure to psychosocial stress has been associated with systemic inflammation and adverse birth outcomes in pregnant women. Thus, it is probable that psychosocial stress and inflammation play a role in the development of HDP. Read More

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http://dx.doi.org/10.1055/s-0040-1713368DOI Listing

[Mobility and Fall Prevention in older Community-dwelling Persons].

Dtsch Med Wochenschr 2020 Jul 2;145(13):932-943. Epub 2020 Jul 2.

An increasing proportion of oldest old persons (over 80 years) accompanies the demographic change. Furthermore, the gender ration will also change and the percentage of older men will increase. Mobility is an important factor for maintaining independence and for "healthy aging". Read More

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http://dx.doi.org/10.1055/a-0922-7535DOI Listing

Artificial Intelligence and Hypertension: Recent Advances and Future Outlook.

Am J Hypertens 2020 Jul 2. Epub 2020 Jul 2.

Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.

Prevention and treatment of hypertension (HTN) is a challenging public health problem. Recent evidence suggests that artificial intelligence (AI) has potential to be a promising tool for reducing the global burden of HTN, and furthering precision medicine related to cardiovascular (CV) diseases including HTN. Since AI can stimulate human thought processes and learning with complex algorithms and advanced computational power, AI can be applied to multimodal and big data, including genetics, epigenetics, proteomics, metabolomics, CV imaging, socioeconomic, behavioral and environmental factors. Read More

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http://dx.doi.org/10.1093/ajh/hpaa102DOI Listing

Developmental effects on sleep-wake patterns in infants receiving a cow's milk-based infant formula with an added prebiotic blend: a Randomized Controlled Trial.

Pediatr Res 2020 Jul 2. Epub 2020 Jul 2.

Clinical Research, Department of Medical Affairs, Mead Johnson Nutrition, 2400 West Lloyd Expy, Evansville, IN, 47721, USA.

Background: Few studies have evaluated nutritive effects of prebiotics on infant behavior state, physiology, or metabolic status.

Methods: In this double-blind randomized study, infants (n = 161) received cow's milk-based infant formula (Control) or similar formula with an added prebiotic blend (polydextrose and galactooligosaccharides [PDX/GOS]) from 14-35 to 112 days of age. Infant wake behavior (crying/fussing, awake/content) and 24-h sleep-wake actograms were analyzed (Baseline, Days 70 and 112). Read More

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http://dx.doi.org/10.1038/s41390-020-1044-xDOI Listing

Often Overlooked and Ignored, but Do Not Underestimate Its Relevance: ADHD in Addiction - Addiction in ADHD.

Eur Addict Res 2020 Jul 2:1-4. Epub 2020 Jul 2.

Professor of Working Mechanisms and Treatment of Addiction, Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000509267DOI Listing

A kinetic model of continuous radiation damage to populations of cells: comparison to the LQ model and application to molecular radiotherapy.

Phys Med Biol 2020 Jul 2. Epub 2020 Jul 2.

Instituto de Investigación Sanitaria de Santiago, Complexo Hospitalario Universitario de Santiago, E-15706 Santiago de Compostela, Santiago de Compostela, SPAIN.

The linear-quadratic (LQ) model to describe the survival of irradiated cells may be the most frequently used biomathematical model in radiotherapy. There has been an intense debate on the mechanistic origin of the LQ model. An interesting approach is that of obtaining LQ-like behavior from kinetic models, systems of differential equations that model the induction and repair of damage. Read More

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http://dx.doi.org/10.1088/1361-6560/aba21dDOI Listing

Zirconium-based metallic glass and zirconia coatings to inhibit bone formation on titanium.

Biomed Mater 2020 Jul 2. Epub 2020 Jul 2.

Central Electrochemical Research Institute CSIR, Karaikudi, Tamil Nadu, INDIA.

Surface modified commercially pure titanium with Zr based thin film metallic glasses (Zr-TFMGs) and ZrO2 thin films were surgically implanted into tibia of rat; the bone formation was analyzed to examine the performance of the coatings as a biomaterial. Zr-TFMGs and ZrO2 thin films were coated on Cp-Ti substrates to monitor the control of assimilation in vitro and in vivo. The microstructural and elemental analyses were carried out for the as deposited thin films by X-ray diffraction, transmission electron microscopy and X-ray photoelectron spectroscopy. Read More

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http://dx.doi.org/10.1088/1748-605X/aba23aDOI Listing

Impact of multiple sclerosis risk loci in postinfectious neurological syndromes.

Mult Scler Relat Disord 2020 Jun 24;44:102326. Epub 2020 Jun 24.

Fondazione Istituto Neurologico Nazionale IRCCS Mondino, via Mondino 2, 27100 Pavia, Italy.

Background: The genetic component of multiple sclerosis (MS) is now set to 200 autosomal common variants. However, it is unclear how genetic knowledge be clinically used in the differential diagnosis between MS and other inflammatory conditions like adult-onset postinfectious neurological syndromes (PINS). The aim of this study was to investigate whether PINS and MS have a shared genetic background using an updated polygenic risk scores. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102326DOI Listing

Control of microbial biofilm formation as an approach for biomaterials synthesis.

Colloids Surf B Biointerfaces 2020 Jun 16;194:111201. Epub 2020 Jun 16.

Planta Piloto de Procesos Industriales Microbiológicos (PROIMI), CONICET, Av. Belgrano y Pasaje Caseros, T4001 MVB, Tucumán Fac. Bioq., Qca. y Farmacia (UNT), Ayacucho 471, 4000, Tucumán, Argentina. Electronic address:

The search for new biomaterials with superior mechanical properties is the focus in the area of materials science. A promising pathway is drawing inspiration from nature to design and develop materials with enhanced properties. In this work, a novel strategy to produce functionalized supramolecular bionanomaterials from the microbial biofilm is reported. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111201DOI Listing

Association of plasma concentrations of oxytocin, vasopressin, and serotonin with docility and friendliness of horses.

Domest Anim Endocrinol 2020 Apr 4;74:106482. Epub 2020 Apr 4.

Department of Animal and Biotechnology Science, Kyungpook National University, Sangju 37224, Republic of Korea; Department of Horse, Companion and Wild Animal Science, Kyungpook National University, Sangju 37224, Republic of Korea. Electronic address:

Oxytocin (OXT) and vasopressin (AVP) have been associated with social interaction and affiliative behavior in animals. Additionally, AVP is known to affect socially aggressive behavior. In addition, serotonin has an association with aggressive behaviors. Read More

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http://dx.doi.org/10.1016/j.domaniend.2020.106482DOI Listing

A quasi-cluster randomized controlled trial of a classroom-based mental health literacy educational intervention to promote knowledge and help-seeking/helping behavior in adolescents.

J Adolesc 2020 Jun 29;82:58-66. Epub 2020 Jun 29.

Department of Physical and Health Education, Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. Electronic address:

Introduction: School-based education is a potentially effective approach for improving mental health literacy (MHL) in adolescents. This study evaluated the effects of the "Short MHL Program (SMHLP)", a brief (50 min), school teacher-led program, on MHL in adolescents in a quasi-cluster randomized controlled trial.

Methods: A total of 975 high school first graders (age 15-16) in Japan were allocated to classes such that gender and academic achievement ratios were almost equivalent at the time of admission to the high school. Read More

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http://dx.doi.org/10.1016/j.adolescence.2020.05.002DOI Listing

Hexaarylbiimidazoles(HABI)-functionalized lyotropic liquid crystalline systems as visible light-responsive materials.

J Colloid Interface Sci 2020 Jun 9;579:379-390. Epub 2020 Jun 9.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia. Electronic address:

Hexaarylbiimidazoles (HABIs) are a promising class of photoswitchable molecule that have received little attention in the literature. Among them, (2,2'-dimethoxydiphenylimidazole)-1,1'-binaphthyl (HABI1) displays unusual negative photochromism and is responsive to green light. This study investigates the potential of HABIs to serve as photo-responsive actuators controlling the structure of lyotropic liquid crystalline (LLC) materials. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.06.006DOI Listing

Abnormal modulation of theta oscillations in children with attention-deficit/hyperactivity disorder.

Neuroimage Clin 2020 Jun 17;27:102314. Epub 2020 Jun 17.

State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China. Electronic address:

Previous studies have found that theta activities exhibit posterior lateralized modulation as well as midfrontal event-related synchronization (ERS) during covert visual attention in adults. The present study investigated whether these theta modulations existed in children and whether they were associated with attentional problems in attention-deficit/hyperactivity disorder (ADHD). Electroencephalography signals were recorded from typically developing (TD) children and children with ADHD (TD: n = 24; ADHD: n = 22) while they performed a cued covert visual attention task. Read More

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http://dx.doi.org/10.1016/j.nicl.2020.102314DOI Listing

Acceptance and commitment therapy combined with vestibular rehabilitation for persistent postural-perceptual dizziness: A pilot study.

Am J Otolaryngol 2020 Jun 11;41(6):102609. Epub 2020 Jun 11.

Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. Electronic address:

Purpose: This study investigated the feasibility of acceptance and commitment therapy for persistent postural-perceptual dizziness and preliminarily verified the long-term effectiveness of the therapy.

Materials And Methods: This study implemented the within-group pre-post comparison design. We enrolled 27 adult patients who met the criteria of persistent postural-perceptual dizziness. Read More

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http://dx.doi.org/10.1016/j.amjoto.2020.102609DOI Listing

Listeners' adaptation to unreliable intonation is speaker-sensitive.

Cognition 2020 Jun 29;204:104372. Epub 2020 Jun 29.

University of Cologne, IfL-Phonetik, Herbert-Lewin-Str 6, 50931 Köln, Germany. Electronic address:

Variable linguistic environments require the ability to quickly update expectations and behavior including speech comprehension. This adaptive capacity is key to understanding how listeners successfully recognize speaker intentions in light of the ubiquitous variability in speech. The present study investigates how listeners' real-time sentence comprehension adapts to speaker-specific prosodic variability. Read More

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http://dx.doi.org/10.1016/j.cognition.2020.104372DOI Listing

Statistical learning and memory.

Cognition 2020 Jun 29;204:104346. Epub 2020 Jun 29.

Department of Psychology, University of California, Los Angeles, United States.

Learners often need to identify and remember recurring units in continuous sequences, but the underlying mechanisms are debated. A particularly prominent candidate mechanism relies on distributional statistics such as Transitional Probabilities (TPs). However, it is unclear what the outputs of statistical segmentation mechanisms are, and if learners store these outputs as discrete chunks in memory. Read More

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http://dx.doi.org/10.1016/j.cognition.2020.104346DOI Listing

Quantitation and localization of beta-blockers and SSRIs accumulation in fathead minnows by complementary mass spectrometry analyses.

Sci Total Environ 2020 Jun 19;741:140331. Epub 2020 Jun 19.

Department of Chemistry, Southern Illinois University Edwardsville, 1 Hairpin Dr., Edwardsville, IL 62026, United States of America. Electronic address:

Beta-blockers and selective serotonin reuptake inhibitors (SSRIs) enter the environment through the improper disposal of drugs in garbage, sinks, or toilets as well as via excretion after their intended use. Beta-blockers and SSRIs are resistant to biodegradation and highly water soluble, leading to limited removal capabilities by wastewater treatment plants. As a result, these compounds can easily enter the aquatic environment in a biologically active state, posing risks to the behavior, anatomy, and physiology of aquatic organisms through exposure. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140331DOI Listing

A neurodynamic model of the interaction between color perception and color memory.

Neural Netw 2020 Jun 12;129:222-248. Epub 2020 Jun 12.

University of Rijeka, Rijeka, Croatia. Electronic address:

The memory color effect and Spanish castle illusion have been taken as evidence of the cognitive penetrability of vision. In the same manner, the successful decoding of color-related brain signals in functional neuroimaging studies suggests the retrieval of memory colors associated with a perceived gray object. Here, we offer an alternative account of these findings based on the design principles of adaptive resonance theory (ART). Read More

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http://dx.doi.org/10.1016/j.neunet.2020.06.008DOI Listing

Combined effect of acoustic cavitation and pulsed discharge plasma on wastewater treatment efficiency in a circulating reactor: A case study of Rhodamine B.

Ultrason Sonochem 2020 Jun 23;68:105236. Epub 2020 Jun 23.

Department of Frontier Science for Advanced Environment, Tohoku University, 980-8579, Japan.

The present study investigates the wastewater treatment performance of an acoustic cavitation assisted plasma (ACAP) process in a circulating reactor using Rhodamine B (RhB) as a model water pollution. The concept of this process was proposed by the authors recently for a batch type rector. The measurements revealed that combining the ultrasound irradiation with pulsed discharge plasma allows the RhB degradation efficiency to be drastically increased as compared with the plasma-alone case. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105236DOI Listing

Influence of sex, menstrual cycle, and hormonal contraceptives on egocentric navigation with or without landmarks.

Psychoneuroendocrinology 2020 Jun 13;120:104768. Epub 2020 Jun 13.

Department of Experimental Psychology, University of Granada, Spain; Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Spain.

This study examines the influence of sex, menstrual cycle, hormonal contraceptives (HC) and sex hormone levels in following egocentric navigation instructions with or without landmarks. Estradiol seem to bias the reference frame for navigation during estrous cycle of female rats. However, previous studies in humans found no differences in overall navigation between women in their early follicular and mid-luteal menstrual cycle phases, whose performance was worse than that of men. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2020.104768DOI Listing

Time to care? The effects of retirement on informal care provision.

J Health Econ 2020 Jun 17;73:102350. Epub 2020 Jun 17.

German Institute for Economic Research Berlin (DIW Berlin), Mohrenstrasse 58, 10117 Berlin, Germany. Electronic address:

This paper analyzes the impact of women's retirement on their informal care provision. Using SOEP data, we address fundamental endogeneity problems by exploiting variation in the German pension system in two complementary ways. We find a significant effect of retirement on informal care provision, when using early retirement age thresholds as instruments. Read More

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http://dx.doi.org/10.1016/j.jhealeco.2020.102350DOI Listing

Redox-sensitive polyglutamic acid-platinum(IV) prodrug grafted nanoconjugates for efficient delivery of cisplatin into breast tumor.

Nanomedicine 2020 Jun 29:102252. Epub 2020 Jun 29.

Department of Inorganic Chemistry, School of Science, China Pharmaceutical University, Longmiandadao 639, Nanjing 211198, PR China. Electronic address:

Targeting cisplatin to the sites of action and decreasing its side effects are still major challenges. Here, we introduced a polyglutamic acid-platinum(IV) prodrug nanoconjugates(γ-PGA-CA-Pt(IV)) constructed by polyglutamic acid and modified platinum(IV) prodrug to reserve the anti-tumor efficacy of cisplatin with decreased side effects. We describe the synthesis, physico-chemical characterization, and redox- and pH-sensitive releasing behavior of the nanoconjugate. Read More

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http://dx.doi.org/10.1016/j.nano.2020.102252DOI Listing

Changes in resting-state brain connectivity following computerized cognitive behavioral therapy for insomnia in dialysis patients: A pilot study.

Gen Hosp Psychiatry 2020 Jun 3;66:24-29. Epub 2020 Jun 3.

Department of Internal Medicine and Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: Insomnia is prevalent among dialysis patients and affects their mortality. Although cognitive behavioral therapy for insomnia (CBTi) is recommended, attending regular face-to-face CBTi sessions is a major challenge for patients. We evaluated the effectiveness of a self-directed computerized CBTi (cCBTi) in dialysis patients, and investigated changes in resting-state brain connectivity and inflammatory cytokines following cCBTi. Read More

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http://dx.doi.org/10.1016/j.genhosppsych.2020.05.013DOI Listing

Rehabilitation for cancer patients in inpatient hospices / palliative care units and achievement of a good death: analyses of combined data from nationwide surveys among bereaved family members.

J Pain Symptom Manage 2020 Jun 29. Epub 2020 Jun 29.

Department of Palliative Nursing, Health Sciences, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575 Japan.

Context: In end-of-life care, rehabilitation for cancer patients is considered to be an important means for improving patients' quality of death and dying (QODD).

Objectives: To determine whether the provision of rehabilitation for cancer patients in palliative care units is associated with the achievement of a good death.

Methods: This study involved a cross-sectional, anonymous, self-report questionnaire survey of families of cancer patients who died in palliative care units in Japan. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2020.06.031DOI Listing

Single-scale time-dependent window-sizes in sliding-window dynamic functional connectivity analysis: a validation study.

Neuroimage 2020 Jun 29:117111. Epub 2020 Jun 29.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA; University of Colorado, Boulder, Colorado, USA; Department of Brain Health, University of Nevada, Las Vegas, Nevada, USA. Electronic address:

During the past ten years, dynamic functional connectivity (FC) has been widely studied using the sliding-window method. A fixed window-size is usually heuristically selected since no consensus exists yet on choice of the optimal window-size. Furthermore, without a known ground-truth, the validity of the computed dynamic FC remains unclear and questionable. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117111DOI Listing

Maturational trajectories of white matter microstructure underlying the right presupplementary motor area reflect individual improvements in motor response cancellation in children and adolescents.

Neuroimage 2020 Jun 29:117105. Epub 2020 Jun 29.

Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. Electronic address:

The ability to effectively suppress motor response tendencies is essential for focused and goal-directed behavior. Here, we tested the hypothesis that developmental improvement in the ability to cancel a motor response is reflected by maturational changes in the white matter underlying the right presupplementary motor area (preSMA) and posterior inferior frontal gyrus (IFG), two cortical key areas of the fronto-basal ganglia "stopping" network. Eighty-eight typically-developing children and adolescents, aged 7-19 years, were longitudinally assessed with the stop-signal task (SST) and diffusion tensor imaging (DTI) of the brain over a period of six years. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117105DOI Listing

Ketamine contributes to the alteration of Ca transient evoked by behavioral tests in the prelimbic area of mPFC: a study on chronic CORT-induced depressive mice.

Neurosci Lett 2020 Jun 29:135220. Epub 2020 Jun 29.

Institute of Neurology, Tianjin Medical University General Hospital, Tianjin, China; Laboratory of Neurobiology, School of Biomedical Engineering, Tianjin Medical University, Tianjin, China. Electronic address:

Recent studies have showed that ketamine is a rapid and efficient antidepressant, but the mechanism of its antidepressant effect is not fully clear. It is still lack of the research investigating the relation between depressive-like behaviors and neuronal activities in specific brain area after administration of ketamine in vivo. Medial prefrontal cortex (mPFC) involved in the pathogenesis of depression. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135220DOI Listing

Insights into the starch gelatinization behavior inside intact cotyledon cells.

Int J Biol Macromol 2020 Jun 29. Epub 2020 Jun 29.

State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, China. Electronic address:

In this work, detailed structural changes of starch within intact cotyledon cells during differential scanning calorimetry (DSC) heating (water: cells ratio of 4:1, v/w) were investigated. Intact cotyledon cells containing raw starch granules from three legumes were isolated and used as materials, followed by simulate DSC heating up to different designated temperatures based on those gelatinization profiles of cells. The swelling power, solubility and gelatinization transition parameters of raw cells were significantly lower than pure starches. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.238DOI Listing

Synthesis, antibacterial activity, and sustainable release of novel α-aminophosphonate derivatives loaded carrageenan cryogel.

Int J Biol Macromol 2020 Jun 29. Epub 2020 Jun 29.

Menoufia University, Faculty of Science, Chemistry Department, Shebin El-Kom, Menoufia, Egypt. Electronic address:

Novel α-aminophosphonates 4 were synthesized via one pot three-component reaction of 4-aminoantipyrine, aldehydes, triphenylphosphite and Lewis acid catalyst. The chemical structures of all the synthesized compounds were elucidated by IR, NMR and MS spectral analysis. The antimicrobial activity of 4 was tested in vitro against pathogenic microbes such as Escherichia coli, Staphylococcus aureus, Aspergillus niger and Candida albicans. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.251DOI Listing

Predictive Value of the Global School Adaptation Questionnaire at 5 Years of Age and Educational Support at 7 Years of Age in Very Preterm Children.

J Pediatr 2020 Jun 29. Epub 2020 Jun 29.

Psychology Laboratory of Pays de la Loire (EA4638), LUNAM, Angers University, Angers, France.

Objective: To assess the Global School Adaptation (GSA) questionnaire of children's abilities and classroom behavior administered to teachers of very preterm children at 5 years of age as a predictor of the need for educational support (grade retention, special class, learning support) at age 7.

Study Design: 858 very preterm children (<33 weeks of gestation) were assessed at 5 years of age using the GSA and again at 7 years to determine the use of educational support. We examined the association between the GSA score and educational support at 7 years and performed a ROC curve analysis. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.06.065DOI Listing

Improvement of lower urinary tract function by a selective serotonin 5-HT receptor agonist, NLX-112, after chronic spinal cord injury.

Exp Neurol 2020 Jun 29:113395. Epub 2020 Jun 29.

Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address:

Spinal cord injury (SCI) above the lumbosacral level results in lower urinary tract dysfunction, including (1) detrusor hyperreflexia, wherein bladder compliance is low, and (2) a lack of external urethral sphincter (EUS) control, leading to detrusor-sphincter dyssynergia (DSD) with poor voiding efficiency. Experimental studies in animals have shown a dense innervation of serotonergic (5-HT) fibers and multiple 5-HT receptors in the spinal reflex circuits that control voiding function. Here, we investigated the efficacy of NLX-112 (a. Read More

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http://dx.doi.org/10.1016/j.expneurol.2020.113395DOI Listing

Striatal and cortical metabotropic glutamate 5 receptor expression and behavioral effects of the positive allosteric modulator CDPPB in a model of DYT1 dystonia.

Pharmacol Biochem Behav 2020 Jun 29:172977. Epub 2020 Jun 29.

Institute of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany.

The metabotropic glutamate 5 (mGlu) receptor is critically involved in corticostriatal plasticity which is disturbed in various animal models of dystonia. Recently, the positive allosteric modulator 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) exerted prodyskinetic effects in a phenotypic model of episodic dystonia. In the DYT1 knock-in (KI) mouse, a model for a persistent type of dystonia, previous ex vivo electrophysiological experiments indicated that mGlu receptors are involved in abnormal striatal plasticity. Read More

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http://dx.doi.org/10.1016/j.pbb.2020.172977DOI Listing

Remotely Triggered Liquefaction of Hydrogel Materials.

ACS Nano 2020 Jul 2. Epub 2020 Jul 2.

Department of Chemistry, Aarhus University, Aarhus 8000, Denmark.

Adaptable behavior such as triggered disintegration affords a broad scope and utility for (bio)materials in diverse applications in materials science and engineering. The impact of such materials continues to grow due to the increased importance of environmental considerations as well as the increased use of implants in medical practices. However, examples of such materials are still few. Read More

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http://dx.doi.org/10.1021/acsnano.0c04522DOI Listing

Voluntary pursuit of negatively valenced stimuli from childhood to early adulthood.

Dev Sci 2020 Jul 2:e13012. Epub 2020 Jul 2.

Department of Psychology and Center for Brain Science, Harvard University.

Although common sense suggests that we are motivated to pursue positive and avoid negative experiences, previous research shows that people regularly seek out negative experiences. In the current study, we characterized this tendency from childhood to young adulthood. Due to the known increases in risky behavior and sensation seeking in adolescence, we hypothesized that adolescents would show an increased engagement with negatively valenced stimuli compared to children and adults. Read More

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http://dx.doi.org/10.1111/desc.13012DOI Listing

Physical activity, health-related quality of life, and adjuvant endocrine therapy-related symptoms in women with hormone receptor-positive breast cancer.

Cancer 2020 Jul 2. Epub 2020 Jul 2.

Department of Oncology, Georgetown University, Washington, DC.

Background: Physical activity (PA) is recommended for women with breast cancer (BC); however, data are sparse on the association of PA with quality of life (QOL) and patient-reported symptoms for women on adjuvant endocrine therapy (AET).

Methods: Women with hormone receptor-positive BC who were taking AET completed standardized surveys about their health-related QOL, AET-related symptoms, and levels of PA using validated measures. A Wald chi-square test and an analysis of variance were used to assess associations with PA and independent variables. Read More

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http://dx.doi.org/10.1002/cncr.33054DOI Listing

Higher early life mortality with lower infant body mass in a free-ranging primate.

J Anim Ecol 2020 Jul 2. Epub 2020 Jul 2.

Department of Anthropology, New York University, USA.

1. Traits that reflect the amount of energy allocated to the offspring by mothers, such as infant body mass, are predicted to have long-lasting effects on offspring fitness. In very long-lived species, such as anthropoid primates, where long and obligate parental care is required for successful recruitment of offspring, there are few studies on the fitness implications of low body mass among infants. Read More

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http://dx.doi.org/10.1111/1365-2656.13291DOI Listing

Induction of fatigue-like behavior by pelvic irradiation of male mice alters cognitive behaviors and BDNF expression.

PLoS One 2020 2;15(7):e0235566. Epub 2020 Jul 2.

National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland, United States of America.

Fatigue and cognitive deficits are often co-occurring symptoms reported by patients after radiation therapy for prostate cancer. In this study, we induced fatigue-like behavior in mice using targeted pelvic irradiation to mimic the clinical treatment regimen and assess cognitive behavioral changes. We observed that pelvic irradiation produced a robust fatigue phenotype, a reduced rate of spontaneous alternation in a Y-maze test, and no behavioral change in an open field test. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235566PLOS

Towards sentiment aided dialogue policy learning for multi-intent conversations using hierarchical reinforcement learning.

PLoS One 2020 2;15(7):e0235367. Epub 2020 Jul 2.

Department of Computer Science and Engineering, Indian Institute of Technology Patna, India.

Purpose: Developing a Dialogue/Virtual Agent (VA) that can handle complex tasks (need) of the user pertaining to multiple intents of a domain is challenging as it requires the agent to simultaneously deal with multiple subtasks. However, majority of these end-to-end dialogue systems incorporate only user semantics as inputs in the learning process and ignore other useful user behavior and information. Sentiment of the user at the time of conversation plays an important role in securing maximum user gratification. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235367PLOS

The use of Unmanned Aerial Vehicles (UAVs) to sample the blow microbiome of small cetaceans.

PLoS One 2020 2;15(7):e0235537. Epub 2020 Jul 2.

Department of Comparative Biomedicine and Food Science, University of Padua, Padua, Italy.

Recent studies describe the use of UAVs in collecting blow samples from large whales to analyze the microbial and viral community in exhaled air. Unfortunately, attempts to collect blow from small cetaceans have not been successful due to their swimming and diving behavior. In order to overcome these limitations, in this study we investigated the application of a specific sampling tool attached to a UAV to analyze the blow from small cetaceans and their respiratory microbiome. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235537PLOS

Red elemental selenium nanoparticles mediated substantial variations in growth, tissue differentiation, metabolism, gene transcription, epigenetic cytosine DNA methylation, and callogenesis in bittermelon (Momordica charantia); an in vitro experiment.

PLoS One 2020 2;15(7):e0235556. Epub 2020 Jul 2.

Department of Biology, Garmsar Branch, Islamic Azad University, Garmsar, Iran.

To gain a better insight into the selenium nanoparticle (nSe) benefits/toxicity, this experiment was carried out to address the behavior of bitter melon seedlings to nSe (0, 1, 4, 10, 30, and 50 mgL-1) or bulk form (selenate). Low doses of nSe increased biomass accumulation, while concentrations of 10 mgL-1 and above were associated with stem bending, impaired root meristem, and severe toxicity. Responses to nSe were distinct from that of bulk in that the nano-type exhibited a higher efficiency to stimulate growth and organogenesis than the bulk. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235556PLOS

Factors associated with access to HIV testing among international students in Japanese language schools in Tokyo.

PLoS One 2020 2;15(7):e0235659. Epub 2020 Jul 2.

Department of Community and Global Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Japan has been recognized for its excellent universal health coverage system. However, the migrant population faces many barriers in accessing health services in Japan. Japan hosts around 260,000 international students, mostly from developing countries. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235659PLOS

Assessment of community vulnerability and medical surge capacity in a foreseeable major disaster.

PLoS One 2020 2;15(7):e0235425. Epub 2020 Jul 2.

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

Objective: Developing an adequate disaster response capacity involves an assessment of available resources in areas that are vulnerable to disaster. Here, we sought to evaluate the gap between predicted damage in a foreseeable major earthquake versus existing municipality-level resources in Tokyo, Japan.

Methods: Our study focused on the 53 municipalities in Tokyo to evaluate the relationships between the predicted number of severe casualties per 1,000 population from a future earthquake, community characteristics, and inpatient bed supply in local hospitals. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235425PLOS

Investigating in-vehicle distracting activities and crash risks for young drivers using structural equation modeling.

PLoS One 2020 2;15(7):e0235325. Epub 2020 Jul 2.

Department of Civil and Architectural Engineering, University of Wyoming, Laramie, Wyoming, United States of America.

Distracted driving has been considered one of the main reasons for traffic crashes in recent times, especially among young drivers. The objectives of this study were to identify the distracting activities in which young drivers engage, assess the most distracting ones based on their experiences, and investigate the factors that might increase crash risk. The data were collected through a self-report questionnaire. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235325PLOS

Similarities and differences in COVID-19 awareness, concern, and symptoms by race and ethnicity in the United States: A cross-sectional survey.

J Med Internet Res 2020 Jul 1. Epub 2020 Jul 1.

Department of Behavioral, Social and Health Education Sciences, Rollins School of Public Health, Emory University, Atlanta, US.

Background: Existing health disparities based on race and ethnicity in the United States are contributing to disparities in morbidity and mortality in the COVID-19 pandemic. We conducted an online survey of American adults to assess similarities and differences by race and ethnicity groups with respect to COVID-19 symptoms, estimates of the extent of the pandemic, knowledge of control measures, and stigma.

Objective: Describe similarities and differences in COVID-19 symptoms, knowledge, and beliefs by race and ethnicity among adults in the US. Read More

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http://dx.doi.org/10.2196/20001DOI Listing

Contraceptive use in Appalachian women who use drugs and were recruited from rural jails.

Soc Work Health Care 2020 Jul;59(6):365-386

Department of Psychology, University at Buffalo , Buffalo, NY, USA.

This study describes a secondary data analysis of contraceptive use across the lifetime and within the six months prior to incarceration in a sample of 400 currently incarcerated women recruited from rural, Appalachian jails, who were using drugs prior to incarceration. Phase 1 (baseline) data from an NIH funded study were used to examine rates of contraceptive use, reasons for nonuse of condoms, and correlates of condom use. Results indicate that the majority (96. Read More

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http://dx.doi.org/10.1080/00981389.2020.1769249DOI Listing

Response to Letter to the Editor: The Contribution of Prescribed and Illicit Opioids to Fatal Overdoses in Massachusetts, 2013-2015.

Public Health Rep 2020 Jul 2:33354920935076. Epub 2020 Jul 2.

164186 Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.1177/0033354920935076DOI Listing

Factors associated with parental acceptance of influenza vaccination for their children: the evidence from four cities of China.

Hum Vaccin Immunother 2020 Jul 2:1-8. Epub 2020 Jul 2.

Center for Public Health Initiatives, University of Pennsylvania , Philadelphia, PA, USA.

Background: It is necessary and urgent to vaccinate 245 million Chinese children against influenza pandemics. The main purpose of this study was to evaluate different psychological and demographic factors that influence parental willingness to vaccinate their children against influenza.

Methods: A hybrid theoretical framework was expanded and verified with 462 sample data collected from four cities in China. Read More

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http://dx.doi.org/10.1080/21645515.2020.1771988DOI Listing
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