637 results match your criteria Behavioral and brain functions : BBF[Journal]


Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'.

Behav Brain Funct 2019 Apr 16;15(1). Epub 2019 Apr 16.

Program in Neuroscience, Middlebury College, Middlebury, VT, 05753, USA.

Our understanding of the networks of genes and protein functions involved in Alcohol Use Disorder (AUD) remains incomplete, as do the mechanisms by which these networks lead to AUD phenotypes. The fruit fly (Drosophila melanogaster) is an efficient model for functional and mechanistic characterization of the genes involved in alcohol behavior. The fly offers many advantages as a model organism for investigating the molecular and cellular mechanisms of alcohol-related behaviors, and for understanding the underlying neural circuitry driving behaviors, such as locomotor stimulation, sedation, tolerance, and appetitive (reward) learning and memory. Read More

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http://dx.doi.org/10.1186/s12993-019-0159-xDOI Listing
April 2019
1 Read

Cerebellar activation associated with model-based estimation of tool-use consequences.

Behav Brain Funct 2019 Apr 16;15(1). Epub 2019 Apr 16.

TOYOTA Collaboration Center, RIKEN Center for Brain Science, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.

Background: Dexterous tool use is considered to be underpinned by model-based control relying on acquired internal models of tools. In particular, this is the case in situations where available sensory feedback regarding the consequences of tool use is restricted. In the present study, we conducted an fMRI study to identify cerebellar involvement in model-based estimation of tool-use consequences using tracking tasks with different levels of visual feedback. Read More

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http://dx.doi.org/10.1186/s12993-019-0158-yDOI Listing

Consequences of multilingualism for neural architecture.

Behav Brain Funct 2019 Mar 25;15(1). Epub 2019 Mar 25.

Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL, 60208, USA.

Language has the power to shape cognition, behavior, and even the form and function of the brain. Technological and scientific developments have recently yielded an increasingly diverse set of tools with which to study the way language changes neural structures and processes. Here, we review research investigating the consequences of multilingualism as revealed by brain imaging. Read More

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http://dx.doi.org/10.1186/s12993-019-0157-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432751PMC
March 2019
2 Reads

Motor cortex and pain control: exploring the descending relay analgesic pathways and spinal nociceptive neurons in healthy conscious rats.

Behav Brain Funct 2019 Mar 25;15(1). Epub 2019 Mar 25.

Laboratory of Neuroscience, Hospital Sírio Libanês, São Paulo, SP, 01308-060, Brazil.

Motor cortex stimulation (MCS) is an effective therapy for refractory neuropathic pain. MCS increases the nociceptive threshold in healthy rats via endogenous opioids, inhibiting thalamic nuclei and activating the periaqueductal gray. It remains unclear how the motor cortex induces top-down modulation of pain in the absence of persistent pain. Read More

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http://dx.doi.org/10.1186/s12993-019-0156-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432755PMC

Anticipation of difficult tasks: neural correlates of negative emotions and emotion regulation.

Behav Brain Funct 2019 Mar 18;15(1). Epub 2019 Mar 18.

Leibniz-Institut für Wissensmedien, Tübingen, Germany.

Background: Difficult cognitive tasks are often associated with negative feelings. This can be already the case for the mere anticipation of having to do a difficult task. For the case of difficult math tasks, it was recently suggested that such a negative emotional response may be exclusive to highly math-anxious individuals. Read More

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http://dx.doi.org/10.1186/s12993-019-0155-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421679PMC

Age-related changes in neuroinflammation and prepulse inhibition in offspring of rats treated with Poly I:C in early gestation.

Behav Brain Funct 2019 Mar 5;15(1). Epub 2019 Mar 5.

Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, No. 388, Jianshe Middle Road, Xinxiang, 453002, Henan, People's Republic of China.

Background: Maternal immune activation (MIA) during gestation can increase the later risk of schizophrenia in adult offspring. Neuroinflammation is believed to underlie this process. Postmortem brain studies have found changes in the neuroimmune systems of patients with schizophrenia. Read More

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http://dx.doi.org/10.1186/s12993-019-0154-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399933PMC
March 2019
3 Reads

Behavioral models in psychopathology: epistemic and semantic considerations.

Behav Brain Funct 2019 Mar 1;15(1). Epub 2019 Mar 1.

Behavior and Welfare Group, Department of Farm Animal Health, Veterinary Faculty, University Utrecht, P.O.Box 80.151, 3508 TD, Utrecht, The Netherlands.

The use of animals in neurosciences has a long history. It is considered indispensable in areas in which "translational" research is deemed invaluable, such as behavioral pharmacology and comparative psychology. Animal models are being used in pharmacology and genetics to screen for treatment targets, and in the field of experimental psychopathology to understand the neurobehavioral underpinnings of a disorder and of its putative treatment. Read More

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http://dx.doi.org/10.1186/s12993-019-0152-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397463PMC
March 2019
1 Read

Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos.

Behav Brain Funct 2019 Mar 1;15(1). Epub 2019 Mar 1.

Department of Psychology, Ben-Gurion University of the Negev, POB 653, Beer-Sheva, Israel.

Background: Signs of pervasive developmental disorder and social deficits were reported in toddlers and children whose mothers were exposed to organophosphate pesticides during pregnancy. Deficits in social preference were reported in adult male mice exposed to chlorpyrifos on gestational days 12-15. This study aimed (a) to test the hypothesis that adult female and male mice that were exposed prenatally to subtoxic doses of chlorpyrifos would be impaired in social behavior and (b) to determine if prenatal chlorpyrifos altered the expression of transcripts for oxytocin in the hypothalamus. Read More

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http://dx.doi.org/10.1186/s12993-019-0153-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397466PMC
March 2019
3 Reads

Narcolepsy and emotional experience: a review of the literature.

Behav Brain Funct 2018 Dec 26;14(1):19. Epub 2018 Dec 26.

Department of Psychology, University of Rome "Sapienza", Via dei Marsi, 78, 00185, Rome, Italy.

Narcolepsy is a chronic sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis. This disease affects significantly the overall patient functioning, interfering with social, work, and affective life. Some symptoms of narcolepsy depend on emotional stimuli; for instance, cataplectic attacks can be triggered by emotional inputs such as laughing, joking, a pleasant surprise, and also anger. Read More

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http://dx.doi.org/10.1186/s12993-018-0151-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305999PMC
December 2018
4 Reads

Selective impairment of attentional set shifting in adults with ADHD.

Behav Brain Funct 2018 Nov 10;14(1):18. Epub 2018 Nov 10.

Experimental Psychology Unit, Helmut-Schmidt-University/University of the Federal Armed Forces Hamburg, Holstenhofweg 85, 22043, Hamburg, Germany.

Background: Task switch protocols are frequently used in the assessment of cognitive control, both in clinical and non-clinical populations. These protocols frequently confound task switch and attentional set shift. The current study investigated the ability of adult ADHD patients to shift attentional set in the context of switching tasks. Read More

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http://dx.doi.org/10.1186/s12993-018-0150-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230251PMC
November 2018
5 Reads

A novel approach to emotion recognition using local subset feature selection and modified Dempster-Shafer theory.

Behav Brain Funct 2018 Oct 31;14(1):17. Epub 2018 Oct 31.

Department of Biomedical Engineering, Faculty of Engineering, Shahed University, Tehran, Iran.

Background: Emotion recognition is an increasingly important field of research in brain computer interactions.

Introduction: With the advance of technology, automatic emotion recognition systems no longer seem far-fetched. Be that as it may, detecting neural correlates of emotion has remained a substantial bottleneck. Read More

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http://dx.doi.org/10.1186/s12993-018-0149-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208176PMC
October 2018
1 Read

Effects of social defeat stress on dopamine D2 receptor isoforms and proteins involved in intracellular trafficking.

Behav Brain Funct 2018 Oct 8;14(1):16. Epub 2018 Oct 8.

Department of Psychiatry, Chonbuk National University Medical School, Jeonju, 561-756, South Korea.

Background: Chronic social defeat stress induces depression and anxiety-like behaviors in rodents and also responsible for differentiating defeated animals into stress susceptible and resilient groups. The present study investigated the effects of social defeat stress on a variety of behavioral parameters like social behavior, spatial learning and memory and anxiety like behaviors. Additionally, the levels of various dopaminergic markers, including the long and short form of the D2 receptor, and total and phosphorylated dopamine and cyclic adenosine 3',5'-monophosphate regulated phosphoprotein-32, and proteins involved in intracellular trafficking were assessed in several key brain regions in young adult mice. Read More

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http://dx.doi.org/10.1186/s12993-018-0148-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176509PMC
October 2018
1 Read

Associations of serotonin transporter gene promoter polymorphisms and monoamine oxidase A gene polymorphisms with oppositional defiant disorder in a Chinese Han population.

Behav Brain Funct 2018 Aug 20;14(1):15. Epub 2018 Aug 20.

Department of Psychiatry, Mental Health Institute, Second Xiangya Hospital of Central South University, Changsha, 410011, China.

Background: Oppositional defiant disorder (ODD) is a behavioral disorder that mainly refers to a recurrent pattern of disobedient, defiant, negativistic and hostile behaviors toward authority figures. Previous studies have showed associations of serotonin transporter (5-HTT) and monoamine oxidase A (MAOA) with behavioral and psychiatric disorders. The purposes of this study were to investigate the potential association of 5-HTT gene promoter polymorphism (5-HTTLPR) and MAOA gene polymorphism with susceptibility to ODD in a Han Chinese school population. Read More

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http://dx.doi.org/10.1186/s12993-018-0147-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102835PMC
August 2018
16 Reads
1.970 Impact Factor

Memory and exploratory behavior impairment in ovariectomized Wistar rats.

Behav Brain Funct 2018 Jul 16;14(1):14. Epub 2018 Jul 16.

Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaoundé, Cameroon.

Background: Estrogen deficiency is linked to changes in several physiological processes, but the extent to which it associates with cognitive changes in menopause context is controversial.

Rationale: We evaluated the impact of ovariectomy on memory processes and normal exploratory behavior in Wistar rats.

Methods: Young adult rats (4-6 months) were either ovariectomized (OVX group) (N = 10), sham operated (N = 10), or untouched (naïve controls) (N = 8). Read More

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http://dx.doi.org/10.1186/s12993-018-0146-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047120PMC
July 2018
25 Reads

Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM).

Behav Brain Funct 2018 Jun 14;14(1):13. Epub 2018 Jun 14.

State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, China.

Background: With increased social pressure, individuals face a high risk of depression. Subsequently, depression affects cognitive behaviour and negatively impacts daily life. Fortunately, the Traditional Chinese Medicine Jia Wei Xiao Yao (JWXY) capsule is effective in reducing depression and improving cognitive behaviour. Read More

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http://dx.doi.org/10.1186/s12993-018-0145-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001006PMC
June 2018
16 Reads

Differential responses of stressful elements to predatory exposure in behavior-lateralized mice.

Behav Brain Funct 2018 Jun 8;14(1):12. Epub 2018 Jun 8.

Department of Microbiology & Immunology, Shantou University Medical College, 22 Xinling Road, Shantou, 515041, Guangdong, People's Republic of China.

Background: Predatory stress as a psychological stressor can elicit the activation of the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in the dialogue of the neuroimmunoendocrine network. The brain has been proven to regulate the activity of the HPA axis by way of lateralization. In the present study, we probed the pivotal elements of the HPA circuitry including CRH, GR and a multifunctional cytokine in behavior-lateralized mice to determine their changes when the animals were subjected to predator exposure. Read More

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http://dx.doi.org/10.1186/s12993-018-0144-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992834PMC
June 2018
7 Reads

Assessing ADHD symptoms in children and adults: evaluating the role of objective measures.

Behav Brain Funct 2018 May 18;14(1):11. Epub 2018 May 18.

Clinical Child and Adolescent Psychology, Department of Psychology, Philipps University Marburg, Gutenbergstr. 18, 35037, Marburg, Germany.

Background: Diagnostic guidelines recommend using a variety of methods to assess and diagnose ADHD. Applying subjective measures always incorporates risks such as informant biases or large differences between ratings obtained from diverse sources. Furthermore, it has been demonstrated that ratings and tests seem to assess somewhat different constructs. Read More

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http://dx.doi.org/10.1186/s12993-018-0143-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960089PMC
May 2018
3 Reads

Sex differences in associations between maternal deprivation and alterations in hippocampal calcium-binding proteins and cognitive functions in rats.

Behav Brain Funct 2018 May 15;14(1):10. Epub 2018 May 15.

Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Background And Objective: Adverse early-life experiences have been suggested as one of the key contributors to neurodevelopmental disorders, such that these experiences influence brain development, cognitive ability and mental health. Previous studies indicated that hippocampal levels of the calcium-binding proteins calretinin (CALR) and calbindin-D28k (CALB) changed in response to maternal deprivation (MD), a model for adverse early-life experiences. We investigated the effects of MD on hippocampal CALR and CALB protein levels and cognitive behaviors, and explored whether these effects were sex-related. Read More

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http://dx.doi.org/10.1186/s12993-018-0142-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952636PMC
May 2018
10 Reads

Magnitude processing of symbolic and non-symbolic proportions: an fMRI study.

Behav Brain Funct 2018 May 10;14(1). Epub 2018 May 10.

Leibniz-Institut für Wissensmedien, Schleichstraße 6, 72076, Tuebingen, Germany.

Background: Recent research indicates that processing proportion magnitude is associated with activation in the intraparietal sulcus. Thus, brain areas associated with the processing of numbers (i.e. Read More

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http://dx.doi.org/10.1186/s12993-018-0141-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944011PMC
May 2018
4 Reads

Neural correlates of interference resolution in the multi-source interference task: a meta-analysis of functional neuroimaging studies.

Behav Brain Funct 2018 Apr 10;14(1). Epub 2018 Apr 10.

Department of Sport Psychology, School of Kinesiology, Shanghai University of Sport, 399 Chang Hai Road, Shanghai, 200438, People's Republic of China.

Background: Interference resolution refers to cognitive control processes enabling one to focus on task-related information while filtering out unrelated information. But the exact neural areas, which underlie a specific cognitive task on interference resolution, are still equivocal. The multi-source interference task (MSIT), as a particular cognitive task, is a well-established experimental paradigm used to evaluate interference resolution. Read More

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http://dx.doi.org/10.1186/s12993-018-0140-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891971PMC
April 2018
8 Reads

Interaction of basolateral amygdala, ventral hippocampus and medial prefrontal cortex regulates the consolidation and extinction of social fear.

Behav Brain Funct 2018 Mar 19;14(1). Epub 2018 Mar 19.

Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic Medical Sciences, Lanzhou University, No. 199 of Donggang West Road, Lanzhou, 730000, Gansu, People's Republic of China.

Background: Following a social defeat, the balanced establishment and extinction of aversive information is a beneficial strategy for individual survival. Abnormal establishment or extinction is implicated in the development of mental disorders. This study investigated the time course of the establishment and extinction of aversive information from acute social defeat and the temporal responsiveness of the basolateral amygdala (BLA), ventral hippocampus (vHIP) and medial prefrontal cortex (mPFC) in this process. Read More

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http://dx.doi.org/10.1186/s12993-018-0139-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858134PMC
March 2018
5 Reads

Left centro-parieto-temporal response to tool-gesture incongruity: an ERP study.

Behav Brain Funct 2018 Mar 13;14(1). Epub 2018 Mar 13.

Department of Occupational Therapy & Graduate Institute of Behavioral Science, Chang Gung University, Taoyuan, Taiwan.

Background: Action semantics have been investigated in relation to context violation but remain less examined in relation to the meaning of gestures. In the present study, we examined tool-gesture incongruity by event-related potentials (ERPs) and hypothesized that the component N400, a neural index which has been widely used in both linguistic and action semantic congruence, is significant for conditions of incongruence.

Methods: Twenty participants performed a tool-gesture judgment task, in which they were asked to judge whether the tool-gesture pairs were correct or incorrect, for the purpose of conveying functional expression of the tools. Read More

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Publisher Site
http://dx.doi.org/10.1186/s12993-018-0138-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848435PMC
March 2018
6 Reads

The neural correlates of mental arithmetic in adolescents: a longitudinal fNIRS study.

Behav Brain Funct 2018 Mar 10;14(1). Epub 2018 Mar 10.

LEAD Graduate School & Research Network, University of Tuebingen, Tuebingen, Germany.

Background: Arithmetic processing in adults is known to rely on a frontal-parietal network. However, neurocognitive research focusing on the neural and behavioral correlates of arithmetic development has been scarce, even though the acquisition of arithmetic skills is accompanied by changes within the fronto-parietal network of the developing brain. Furthermore, experimental procedures are typically adjusted to constraints of functional magnetic resonance imaging, which may not reflect natural settings in which children and adolescents actually perform arithmetic. Read More

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http://dx.doi.org/10.1186/s12993-018-0137-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845230PMC
March 2018
5 Reads

Mitochondrial dysfunction and autism: comprehensive genetic analyses of children with autism and mtDNA deletion.

Behav Brain Funct 2018 Feb 20;14(1). Epub 2018 Feb 20.

Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Tömő Str. 25-29, Budapest, 1083, Hungary.

Background: The etiology of autism spectrum disorders (ASD) is very heterogeneous. Mitochondrial dysfunction has been described in ASD; however, primary mitochondrial disease has been genetically proven in a small subset of patients. The main goal of the present study was to investigate correlations between mitochondrial DNA (mtDNA) changes and alterations of genes associated with mtDNA maintenance or ASD. Read More

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http://dx.doi.org/10.1186/s12993-018-0135-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819172PMC
February 2018
11 Reads

Correction to: Mercury exposure, nutritional deficiencies and metabolic disruptions may affect learning in children.

Behav Brain Funct 2018 02 7;14(1). Epub 2018 Feb 7.

Shepherd University, Shepherdstown, WV, USA.

The original version of this article [1] unfortunately contained an error which has since been acknowledged in this Correction article. The URL link in the Reference 19 was broken and it needs to be replaced with the active link given below. Read More

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http://dx.doi.org/10.1186/s12993-018-0136-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803860PMC
February 2018
6 Reads
1.972 Impact Factor

Frontal dysconnectivity in 22q11.2 deletion syndrome: an atlas-based functional connectivity analysis.

Behav Brain Funct 2018 Jan 20;14(1). Epub 2018 Jan 20.

Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY, USA.

Background: 22q11.2 deletion syndrome (22q11DS) is a neurodevelopmental syndrome associated with deficits in cognitive and emotional processing. This syndrome represents one of the highest risk factors for the development of schizophrenia. Read More

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http://dx.doi.org/10.1186/s12993-018-0134-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775582PMC
January 2018
33 Reads

Association between cerebral dopamine neurotrophic factor (CDNF) 2 polymorphisms and schizophrenia susceptibility and symptoms in the Han Chinese population.

Behav Brain Funct 2018 Jan 3;14(1). Epub 2018 Jan 3.

Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.

Background: Schizophrenia (SZ) is a complex polygenic psychiatric disorder caused in part by abnormal dopamine levels. Cerebral dopamine neurotrophic factor (CDNF) 2 is known to protect and repair the dopaminergic system. Dopamine dysfunction is one of the pathogenesis of SZ. Read More

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http://dx.doi.org/10.1186/s12993-017-0133-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753570PMC
January 2018
77 Reads

EARLY gestational exposure to isoflurane causes persistent cell loss in the dentate gyrus of adult male rats.

Behav Brain Funct 2017 Dec 26;13(1):14. Epub 2017 Dec 26.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: Our previous research showed that 4 h of maternal anesthesia with isoflurane during early gestation in pregnant rats leads to a deficit in spatial memory of adult male offspring. Because spatial memory is predominantly a hippocampally-mediated task, we asked the question if early gestational exposure to isoflurane affects development of the hippocampus in the offspring.

Findings: Previously behaviorally characterized adult male rats that were exposed to isoflurane during second trimester were sacrificed at 4 months of age (N = 10 and 13, control and isoflurane groups, respectively) for quantitative histology of hippocampal subregions. Read More

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http://dx.doi.org/10.1186/s12993-017-0132-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744391PMC
December 2017
20 Reads

Behavioral sensitivity of Japanese children with and without ADHD to changing reinforcer availability: an experimental study using signal detection methodology.

Behav Brain Funct 2017 Sep 25;13(1):13. Epub 2017 Sep 25.

Human Developmental Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna, Okinawa, 904-0495, Japan.

Background: Most research on motivational processes in attention deficit hyperactivity disorder (ADHD) has been undertaken in Western Europe and North America. The extent to which these findings apply to other cultural groups is unclear. The current study evaluated the behavioral sensitivity of Japanese children with and without ADHD to changing reward availability. Read More

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http://dx.doi.org/10.1186/s12993-017-0131-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613339PMC
September 2017
11 Reads

Cognitive behavioural therapy attenuates the enhanced early facial stimuli processing in social anxiety disorders: an ERP investigation.

Behav Brain Funct 2017 Jul 28;13(1):12. Epub 2017 Jul 28.

CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China.

Background: Previous studies of patients with social anxiety have demonstrated abnormal early processing of facial stimuli in social contexts. In other words, patients with social anxiety disorder (SAD) tend to exhibit enhanced early facial processing when compared to healthy controls. Few studies have examined the temporal electrophysiological event-related potential (ERP)-indexed profiles when an individual with SAD compares faces to objects in SAD. Read More

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http://dx.doi.org/10.1186/s12993-017-0130-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534051PMC
July 2017
33 Reads

Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test.

Behav Brain Funct 2017 Jun 27;13(1):11. Epub 2017 Jun 27.

Collaborative Innovation Center for Neuropsychiatric Disorders and Mental Health, Hefei, Anhui, China.

Background: Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Read More

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http://dx.doi.org/10.1186/s12993-017-0129-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485500PMC
June 2017
10 Reads

Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development.

Behav Brain Funct 2017 Jun 1;13(1):10. Epub 2017 Jun 1.

Department of Zoology, College of Sciences, Faculty of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.

Background: Green tea extract (GTE) has various health promoting effects on animals and humans. However, the effects of perinatal exposure to GTE on the behavioral aspects of offspring have not been elucidated thus far. GTE was provided for pregnant female mice at concentrations of either 20 or 50 g/L, beginning the day of conception until the third week after delivery, postnatal day 22 (PD 22). Read More

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http://dx.doi.org/10.1186/s12993-017-0128-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452299PMC
June 2017
9 Reads

Sex differences in avoidance behavior after perceiving potential risk in mice.

Behav Brain Funct 2017 May 5;13(1). Epub 2017 May 5.

Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Keihanna Science City, Nara, 630-0192, Japan.

Background: Sex has been considered as a potential factor regulating individual behaviors in different contexts. Recently, findings on sex differences in the neuroendocrine circuit have expanded due to exact measurements and control of neuronal activity, while findings on sex differences in behavioral phenotypes are limited. One efficient way to determine the miscellaneous aspects of a sexually different behavior is to segment it into a set of simpler responses induced by discrete scenes. Read More

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http://dx.doi.org/10.1186/s12993-017-0126-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420094PMC
May 2017
28 Reads

Interaction between cytochrome P450 2A6 and Catechol-O-Methyltransferase genes and their association with smoking risk in young men.

Behav Brain Funct 2017 May 4;13(1). Epub 2017 May 4.

Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, No. 666 Buzih Road, Beitun District, Taichung City, 40601, Taiwan.

Background: Although some effects of gene-gene interactions on nicotine-dopamine metabolism for smoking behavior have been reported, polymorphisms of cytochrome P450 (CYP) 2A6 and catechol-O-methyltransferase (COMT) have not been studied together to determine their effects on smokers. The aim of this study was to investigate the effects of the interaction between the CYP 2A6 and COMT genes on smoking behavior in young Taiwanese men.

Results: A self-report questionnaire regarding smoking status was administered to 500 young men. Read More

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http://dx.doi.org/10.1186/s12993-017-0127-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418756PMC
May 2017
11 Reads

Effects of GABA receptors in the insula on recognition memory observed with intellicage.

Behav Brain Funct 2017 Apr 17;13(1). Epub 2017 Apr 17.

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, Ningxia, China.

Background: Insular function has gradually become a topic of intense study in cognitive research. Recognition memory is a commonly studied type of memory in memory research. GABAR has been shown to be closely related to memory formation. Read More

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http://dx.doi.org/10.1186/s12993-017-0125-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392977PMC
April 2017
15 Reads

Brain structural investigation and hippocampal tractography in medication overuse headache: a native space analysis.

Behav Brain Funct 2017 Apr 8;13(1). Epub 2017 Apr 8.

UMR 5287-CNRS, INCIA-Bordeaux University, 33076, Bordeaux, France.

Background: Spatial normalization of brain images, a prerequisite for voxel based morphometry analysis, may account for the large variability of the volumetric data in medication overuse headache (MOH); possibly because this disease concerns patients differing on both sex and age, and hence with different brain size and shape.

Methods: The present study aimed at providing a subject-based analysis of macrostructure using a native space volumes segmentation (Freesurfer), and microstructure using a region of interest (ROI: i.e. Read More

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http://behavioralandbrainfunctions.biomedcentral.com/article
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http://dx.doi.org/10.1186/s12993-017-0124-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385056PMC
April 2017
8 Reads

Cognitive-enhancing and antioxidant activities of the aqueous extract from Markhamia tomentosa (Benth.) K. Schum. stem bark in a rat model of scopolamine.

Behav Brain Funct 2017 Mar 28;13(1). Epub 2017 Mar 28.

Department of Biology, Alexandru Ioan Cuza University of Iasi, Bd. Carol I, No. 11, 700506, Iasi, Romania.

Background: Plants of the genus Markhamia have been traditionally used by different tribes in various parts of West African countries, including Cameroun. Markhamia tomentosa (Benth.) K. Read More

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http://dx.doi.org/10.1186/s12993-017-0123-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371259PMC
March 2017
22 Reads

The social brain network in 22q11.2 deletion syndrome: a diffusion tensor imaging study.

Behav Brain Funct 2017 Feb 16;13(1). Epub 2017 Feb 16.

Department of Psychiatry, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.

Background: Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder that is associated with a 25-fold increase in schizophrenia. Read More

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http://dx.doi.org/10.1186/s12993-017-0122-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314621PMC
February 2017
26 Reads

Logical fallacies in animal model research.

Authors:
Espen A Sjoberg

Behav Brain Funct 2017 Feb 15;13(1). Epub 2017 Feb 15.

Department of Behavioral Sciences, Oslo and Akershus University College of Applied Sciences, St. Olavs Plass, P.O. Box 4, 0130, Oslo, Norway.

Background: Animal models of human behavioural deficits involve conducting experiments on animals with the hope of gaining new knowledge that can be applied to humans. This paper aims to address risks, biases, and fallacies associated with drawing conclusions when conducting experiments on animals, with focus on animal models of mental illness.

Conclusions: Researchers using animal models are susceptible to a fallacy known as false analogy, where inferences based on assumptions of similarities between animals and humans can potentially lead to an incorrect conclusion. Read More

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http://dx.doi.org/10.1186/s12993-017-0121-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312558PMC
February 2017
10 Reads

Mothers' pupillary responses to infant facial expressions.

Behav Brain Funct 2017 Feb 6;13(1). Epub 2017 Feb 6.

Tampere Center for Child Health Research, School of Medicine, University of Tampere, Lääkärinkatu 1, 33520, Tampere, Finland.

Background: Human parental care relies heavily on the ability to monitor and respond to a child's affective states. The current study examined pupil diameter as a potential physiological index of mothers' affective response to infant facial expressions.

Methods: Pupillary time-series were measured from 86 mothers of young infants in response to an array of photographic infant faces falling into four emotive categories based on valence (positive vs. Read More

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http://dx.doi.org/10.1186/s12993-017-0120-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292805PMC
February 2017
7 Reads

Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb.

Behav Brain Funct 2017 Jan 26;13(1). Epub 2017 Jan 26.

INBB, National Insitute of Biostructures and Biosystems, Rome, Italy.

Background: Olfaction is often affected in parkinsonian patients, but dopaminergic cells in the olfactory bulb are not affected by some Parkinson-inducing drugs. We investigated whether the drug MPTP produces the olfactory deficits typical of Parkinson and affects the olfactory bulb in mice.

Findings: Lesioned and control mice were tested for olfactory search, for motor and exploratory behavior. Read More

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http://dx.doi.org/10.1186/s12993-017-0119-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267367PMC
January 2017
10 Reads

Venlafaxine ameliorates the depression-like behaviors and hippocampal S100B expression in a rat depression model.

Behav Brain Funct 2016 Dec 8;12(1):34. Epub 2016 Dec 8.

Department of Child and Adolescent, Public Health College, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, Henan, China.

Background: Accumulating evidence has indicated that S100B may be involved in the pathophysiology of depression. No published study has examined the effect of the antidepressant drug venlafaxine on S100B in animal models of depression. This study investigated S100B expression in the hippocampus and assessed the effect of venlafaxine on S100B mRNA level and protein expression in rats exposed to chronic unpredictable mild stress (CUMS). Read More

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http://dx.doi.org/10.1186/s12993-016-0116-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146825PMC
December 2016
39 Reads
1.970 Impact Factor

Scutellaria barbata flavonoids alleviate memory deficits and neuronal injuries induced by composited Aβ in rats.

Behav Brain Funct 2016 Dec 8;12(1):33. Epub 2016 Dec 8.

Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia/Institute of Traditional Chinese Medicine, Chengde Medical College/Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, 067000, China.

Background: The aim of the present study was to investigate the effects of Scutellaria barbata flavonoids (SBF) on memory impairment and neuronal injury induced by amyloid beta protein 25-35 in combination with aluminum trichloride (AlCl3) and recombinant human transforming growth factor-β1 (RHTGF-β1) (composited Aβ) in rats.

Methods: The composited Aβ-treated model of Alzheimer's disease (AD)-like memory impairment and neuronal injury was established in male rats by right intracerebroventricular injection of composited Aβ, and the effects of SBF were assessed using this rat model. Spatial learning and memory of rats were assessed in the Morris water maze, and neuronal injury was assessed by light and electron microscopy with hematoxylin-eosin or uranyl acetate and lead nitrate-sodium citrate staining, respectively. Read More

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http://dx.doi.org/10.1186/s12993-016-0118-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146811PMC
December 2016
21 Reads

Patterns of motor activity in spontaneously hypertensive rats compared to Wistar Kyoto rats.

Behav Brain Funct 2016 Dec 1;12(1):32. Epub 2016 Dec 1.

Oslo and Akershus University College, Stensberggata 26, 0170, Oslo, Norway.

Background: Increased motor activity is a defining characteristic of patients with ADHD, and spontaneously hypertensive rats have been suggested to be an animal model of this disorder. In the present study, we wanted to use linear and non-linear methods to explore differences in motor activity patterns in SHR/NCrl rats compared to Wistar Kyoto (WKY/NHsd) rats.

Methods: A total number of 42 rats (23 SHR/NCrl and 19 WKY/NHsd, male and female) were tested. Read More

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http://dx.doi.org/10.1186/s12993-016-0117-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131462PMC
December 2016
7 Reads

A functional magnetic resonance imaging investigation of visual hallucinations in the human striate cortex.

Behav Brain Funct 2016 Nov 29;12(1):31. Epub 2016 Nov 29.

Lahore University of Managment Sciences, Lahore, Pakistan.

Purpose: Human beings frequently experience fear, phobia, migraine and hallucinations, however, the cerebral mechanisms underpinning these conditions remain poorly understood. Towards this goal, in this work, we aim to correlate the human ocular perceptions with visual hallucinations, and map them to their cerebral origins.

Methods: An fMRI study was performed to examine the visual cortical areas including the striate, parastriate and peristriate cortex in the occipital lobe of the human brain. Read More

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http://dx.doi.org/10.1186/s12993-016-0115-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126868PMC
November 2016
22 Reads

Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population.

Behav Brain Funct 2016 Nov 21;12(1):30. Epub 2016 Nov 21.

Department of Child and Adolescent, Public Health College, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, Henan, China.

Background: Oppositional defiant disorder (ODD) is a behavioral disorder of school-age population. It is well known that 5-HT dysfunction is correlated with impulsivity, which is one of the common characteristics of ODD. The enzyme tryptophan hydroxylase-2 (TPH-2) synthesizes 5-HT in serotonergic neurons of the midbrain raphe. Read More

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http://dx.doi.org/10.1186/s12993-016-0113-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117514PMC
November 2016
27 Reads

The role of C957T, TaqI and Ser311Cys polymorphisms of the DRD2 gene in schizophrenia: systematic review and meta-analysis.

Behav Brain Funct 2016 Nov 9;12(1):29. Epub 2016 Nov 9.

División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, Mexico.

Background: The association between the dopamine D2 receptor (DRD2) gene and schizophrenia has been studied though no conclusive outcomes have been attained. The aim of this study was to perform a systematic review and meta-analysis to explore the relation between three polymorphisms of the DRD2 gene (C957T, TaqI and Ser311Cys) and schizophrenia.

Methods: The search was made in PubMed and EBSCO databases (up to February 2016). Read More

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http://dx.doi.org/10.1186/s12993-016-0114-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101652PMC
November 2016
6 Reads

Age, environment, object recognition and morphological diversity of GFAP-immunolabeled astrocytes.

Behav Brain Funct 2016 Oct 10;12(1):28. Epub 2016 Oct 10.

Laboratório de Investigações Em Neurodegeneração e Infecção, Instituto de Ciências Biológicas, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Rua dos Mundurucus 4487, Guamá, Belém, Pará, CEP 66073-000, Brazil.

Background: Few studies have explored the glial response to a standard environment and how the response may be associated with age-related cognitive decline in learning and memory. Here we investigated aging and environmental influences on hippocampal-dependent tasks and on the morphology of an unbiased selected population of astrocytes from the molecular layer of dentate gyrus, which is the main target of perforant pathway.

Results: Six and twenty-month-old female, albino Swiss mice were housed, from weaning, in a standard or enriched environment, including running wheels for exercise and tested for object recognition and contextual memories. Read More

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http://dx.doi.org/10.1186/s12993-016-0111-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056502PMC
October 2016
25 Reads

A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs.

Behav Brain Funct 2016 Sep 29;12(1):27. Epub 2016 Sep 29.

Department of Veterinary Biosciences and Research Programs Unit, Molecular Neurology, University of Helsinki and Folkhälsan Research Center, Biomedicum Helsinki, P.O.Box 63, 00014, Helsinki, Finland.

Background: Attention deficit hyperactivity disorder (ADHD) is a prevalent and multifactorial neuropsychiatric disorder in the human population worldwide. Complex etiology and clinical heterogeneity have challenged the research, diagnostics and treatment of the disease. Hyperactive and impulsive behaviour has also been observed in dogs, and they could offer a physiologically relevant model for human ADHD. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043524PMC
http://dx.doi.org/10.1186/s12993-016-0112-1DOI Listing
September 2016
6 Reads

Visual food stimulus changes resting oscillatory brain activities related to appetitive motive.

Behav Brain Funct 2016 Sep 26;12(1):26. Epub 2016 Sep 26.

Department of Physiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, Osaka, 545-8585, Japan.

Background: Changes of resting brain activities after visual food stimulation might affect the feeling of pleasure in eating food in daily life and spontaneous appetitive motives. We used magnetoencephalography (MEG) to identify brain areas related to the activity changes.

Methods: Fifteen healthy, right-handed males [age, 25. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037892PMC
http://dx.doi.org/10.1186/s12993-016-0110-3DOI Listing
September 2016
9 Reads