2,528,719 results match your criteria Behavioral Psychology-psicologia Conductual[Journal]


Relationship between health-related quality of life and blood pressure control in patients with uncontrolled hypertension.

J Clin Hypertens (Greenwich) 2020 Jul 11. Epub 2020 Jul 11.

Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

We sought to investigate the psychosocial characteristics of patients with uncontrolled hypertension and examine factors that influence blood pressure (BP) control. A total of 1011 patients with uncontrolled hypertension were enrolled in 13 tertiary hospitals. Uncontrolled hypertension was defined as systolic BP ≥140 mm Hg or diastolic BP ≥90 mm Hg despite on antihypertensive therapy. Read More

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http://dx.doi.org/10.1111/jch.13941DOI Listing

Language characterization in 16p11.2 deletion and duplication syndromes.

Am J Med Genet B Neuropsychiatr Genet 2020 Jul 11. Epub 2020 Jul 11.

Simons Foundation, New York, New York, USA.

Expressive language impairment is one of the most frequently associated clinical features of 16p11.2 copy number variations (CNV). However, our understanding of the language profiles of individuals with 16p11. Read More

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http://dx.doi.org/10.1002/ajmg.b.32809DOI Listing

The role of mab-3 in spermatogenesis and ontogenesis of pinewood nematode, Bursaphelenchus xylophilus.

Pest Manag Sci 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory of Subtropical Silviculture, College of Forestry and Biotechnology, Zhejiang Agricultural & Forestry University, Hangzhou, 311300, China.

Background: Bursaphelenchus xylophilus is one of the most destructive invasive species, causing extensive economic losses worldwide. The sex ratio of female to male of B. xylophilus plays an important role in the nematode infestation. Read More

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http://dx.doi.org/10.1002/ps.6001DOI Listing

Priming of microglia with IFN-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects.

Glia 2020 Jul 11. Epub 2020 Jul 11.

School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China.

Neuroinflammation driven by interferon-gamma (IFN-γ) and microglial activation has been linked to neurological disease. However, the effects of IFN-γ-activated microglia on hippocampal neurogenesis and behavior are unclear. In the present study, IFN-γ was administered to mice via intracerebroventricular injection. Read More

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http://dx.doi.org/10.1002/glia.23878DOI Listing

Issues of theory and method in the analysis of Paleolithic mortuary behavior: A view from Shanidar Cave.

Evol Anthropol 2020 Jul 11. Epub 2020 Jul 11.

McDonald Institute for Archaeological Research, University of Cambridge, Cambridge, UK.

Mortuary behavior (activities concerning dead conspecifics) is one of many traits that were previously widely considered to have been uniquely human, but on which perspectives have changed markedly in recent years. Theoretical approaches to hominin mortuary activity and its evolution have undergone major revision, and advances in diverse archeological and paleoanthropological methods have brought new ways of identifying behaviors such as intentional burial. Despite these advances, debates concerning the nature of hominin mortuary activity, particularly among the Neanderthals, rely heavily on the rereading of old excavations as new finds are relatively rare, limiting the extent to which such debates can benefit from advances in the field. Read More

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http://dx.doi.org/10.1002/evan.21854DOI Listing

Huntingtin gene CAG repeat size affects autism risk: Family-based and case-control association study.

Am J Med Genet B Neuropsychiatr Genet 2020 Jul 11. Epub 2020 Jul 11.

Interdepartmental Program "Autism 0-90", "Gaetano Martino" University Hospital, University of Messina, Messina, Italy.

The Huntingtin (HTT) gene contains a CAG repeat in exon 1, whose expansion beyond 39 repeats consistently leads to Huntington's disease (HD), whereas normal-to-intermediate alleles seemingly modulate brain structure, function and behavior. The role of the CAG repeat in Autism Spectrum Disorder (ASD) was investigated applying both family-based and case-control association designs, with the SCA3 repeat as a negative control. Significant overtransmission of "long" CAG alleles (≥17 repeats) to autistic children and of "short" alleles (≤16 repeats) to their unaffected siblings (all p < 10 ) was observed in 612 ASD families (548 simplex and 64 multiplex). Read More

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http://dx.doi.org/10.1002/ajmg.b.32806DOI Listing

Diet diversity was eminently limited in Mzimba, Malawi which resulted in stunting in spite of foods being available in markets.

Pediatr Int 2020 Jul 11. Epub 2020 Jul 11.

St Mary's hospital, 422 Tsubuku honmachi, Kurume, 830-8543, Fukuoka, Japan.

Background: Stunting, the most common type of malnutrition has been a big burden for developing countries such as the Republic of Malawi. The state of malnutrition and the eating behavior of children were surveyed at the border areas with Zambia through anthropometrical measurements and Household Diet Diversity Scores.

Methods: Two rural sites were chosen to compare the impact of the intervention of empowering communities with nutritional knowledge. Read More

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http://dx.doi.org/10.1111/ped.14382DOI Listing

Density-induced social stress alters oxytocin and vasopressin activities in the brain of a small rodent species.

Integr Zool 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory of Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

It is known that social stress could alter oxytocin (OT) and arginine-vasopressin (AVP) expression in specific regions of brains which regulate the aggressive behavior of small rodents, but the effects of density-induced social stress are still unknown. Brandt's voles (Lasiopodomys brandtii) is a small herbivores in the grassland of China, but the underlying neurological mechanism of population regulation is still unknown. We tested the effects of housing density of Brandt's voles on OT/AVP system with physical contact (allowing aggression) and without physical contact (not allowing aggression) under laboratory conditionunder laboratory conditions. Read More

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http://dx.doi.org/10.1111/1749-4877.12467DOI Listing

Dorsal hippocampus- and ACC-projecting medial septum neurons differentially contribute to the recollection of episodic-like memory.

FASEB J 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, School of Basic Medical Sciences, Institutes of Brain Science, Fudan University, Shanghai, China.

Episodic memory refers to the recollection of previous experiences containing specific temporal, spatial, and emotional information. The ability to recollect episodic memory requires coordination of multiple brain regions, including the hippocampus (HPC) and the cingulate cortex. While the afferents into HPC and cingulate cortex that orchestrate the episodic memory remain unclear. Read More

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http://dx.doi.org/10.1096/fj.202000398RDOI Listing

Functional and behavioral signatures of Kv7 activator drug subtypes.

Epilepsia 2020 Jul 11. Epub 2020 Jul 11.

Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.

Objective: Voltage-gated potassium channels of the KCNQ (Kv7) family are targeted by a variety of activator compounds with therapeutic potential for treatment of epilepsy. Exploration of this drug class has revealed a variety of effective compounds with diverse mechanisms. In this study, we aimed to clarify functional criteria for categorization of Kv7 activator compounds, and to compare the effects of prototypical drugs in a zebrafish larvae model. Read More

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http://dx.doi.org/10.1111/epi.16592DOI Listing

Sense of community, pathway to, or bridge from alienation?

J Community Psychol 2020 Jul 11. Epub 2020 Jul 11.

College of Education, Towson University, Towson, Maryland.

Psychological Sense of Community (PSOC) represents a formative conceptual offering of Community Psychology to the social sciences. Nearly five decades ago, PSOC offered a window into the influence of ecological factors to understanding the emotional and behavioral well-being of members of disenfranchised and underserved segments of the population, especially members of minority and low-income subgroups. Our discipline's founders viewed PSOC as one promising vehicle for pursuing the desired paradigmatic shift from individual to systemically focused interventions to achieve intended outcomes of the emerging community mental health movement. Read More

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http://dx.doi.org/10.1002/jcop.22406DOI Listing

Sociodemographic factors and prenatal care behaviors associated with unplanned pregnancy in a Brazilian birth cohort study.

Int J Gynaecol Obstet 2020 Jul 11. Epub 2020 Jul 11.

Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.

Objective: To identify the sociodemographic factors and prenatal behavior characteristics associated with unplanned pregnancy.

Methods: A cross-sectional survey was conducted of mothers of newborns enrolled in a birth cohort in Ribeirão Preto, Brazil. Questionnaires were administered to postpartum women. Read More

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http://dx.doi.org/10.1002/ijgo.13305DOI Listing

Guillain-Barre Syndrome Associated with SARS-CoV-2 Detection and a COVID-19 Infection in a Child.

J Pediatric Infect Dis Soc 2020 Jul 11. Epub 2020 Jul 11.

Faculty of Behavioral, Management and Social Sciences, Department Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.

Coronavirus disease (COVID-19) is caused by SARS-CoV-2. Physicians in China reported what is believed to be the first adult case of a SARS-CoV-2 infection associated with acute Guillain-Barré syndrome (GBS), followed by five adult Italian patients and another case in the United States of America. In the current report we present one of the first descriptions of an association of GBS and SARS-CoV-2 infection within a child. Read More

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http://dx.doi.org/10.1093/jpids/piaa086DOI Listing

Eating disorder attitudes and disordered eating behaviors as measured by the Eating Disorder Examination Questionnaire (EDE-Q) among cisgender lesbian women.

Body Image 2020 Jul 8;34:215-220. Epub 2020 Jul 8.

The PRIDE Study/PRIDEnet, Stanford University School of Medicine, Stanford, CA, United States; Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, United States.

The Eating Disorder Examination Questionnaire (EDE-Q) is a measure of eating disorder attitudes and disordered eating behaviors. Prior descriptive studies of the EDE-Q for women either did not assess or omitted reporting sexual orientation. This study's objective was to assess eating disorder attitudes and disordered eating behaviors as measured by the EDE-Q among cisgender lesbian women. Read More

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http://dx.doi.org/10.1016/j.bodyim.2020.06.005DOI Listing

Response of antibiotic resistance genes in constructed wetlands during treatment of livestock wastewater with different exogenous inducers: Antibiotic and antibiotic-resistant bacteria.

Bioresour Technol 2020 Jul 6;314:123779. Epub 2020 Jul 6.

Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China. Electronic address:

This work aimed to study the behavior of antibiotic resistance genes (ARGs) in constructed wetlands with different exogenous inducers additions (oxytetracycline and its resistant bacteria) by high-throughput quantitative polymerase chain reaction. Results indicated that constructed wetlands have the potential to reduce ARGs relative abundances in wastewater, and the total ARGs removal efficiency could exceed 60%. ARGs profile in the effluent differed from that in the influent, and that did not directly reflect the export of dominant ARGs in wetland biofilms. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123779DOI Listing

Intrapersonal and interpersonal pathways linking 21st birthday celebration beliefs, intentions, and drinking behavior.

Addict Behav 2020 Jun 26;110:106526. Epub 2020 Jun 26.

Department of Psychiatry and Behavioral Sciences, University of Washington, USA.

In the United States, turning 21 often involves heavy drinking and high rates of alcohol-related consequences. Friends are an important source of social influence on young adult drinking, including during 21st birthdays. However, research is needed to investigate the specific pathways through which this interpersonal influence occurs. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106526DOI Listing

Buying despite negative consequences: Interaction of craving, implicit cognitive processes, and inhibitory control in the context of buying-shopping disorder.

Addict Behav 2020 Jun 26;110:106523. Epub 2020 Jun 26.

Department of Clinical Psychology and Psychotherapy, University of Bamberg, Bamberg, Germany.

Background: Buying-shopping disorder (BSD) is a severe mental disorder in which individuals lose control over their buying/shopping behavior. It is debated whether BSD shares characteristics with other behavioral addictions. The current study aimed at investigating addiction-related concepts, i. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106523DOI Listing

Resilience is associated with importance of quitting in homeless adult smokers.

Addict Behav 2020 Jun 21;110:106515. Epub 2020 Jun 21.

Department of Sociology, Providence College, USA.

Objective: The prevalence of cigarette smoking in homeless populations is disproportionately high with rates between 57 and 80%. Resilience may affect a smoker's ability to successfully quit smoking. This cross-sectional study examined the association between resilience levels and smoking behaviors in homeless adults. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106515DOI Listing

Assessment of prescription stimulant misuse among college students using the MMPI-2-RF.

Addict Behav 2020 Jun 11;110:106511. Epub 2020 Jun 11.

Department of Psychology, Central Michigan University, United States.

Prescription stimulant misuse (PSM) is a growing concern on college campuses and more research is needed to validate clinical measures commonly used for the assessment of risk for PSM among college students. The present study examined correlations between scores on the Minnesota Multiphasic Personality Inventory-Second Edition-Restructured Form (MMPI-2-RF) and self- and peer-reported misuse of prescription stimulants and other drugs in a sample of 96 pairs (included within a total N = 212) of undergraduate students. Nearly half of the participants (48%) reported that they had been offered prescription stimulants and one quarter (26%) reported trying someone else's prescription stimulant medications, often to perform better academically. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106511DOI Listing

Drinking to cope with the pandemic: The unique associations of COVID-19-related perceived threat and psychological distress to drinking behaviors in American men and women.

Addict Behav 2020 Jun 27;110:106532. Epub 2020 Jun 27.

Dalhousie University, Canada.

The 2019 Coronavirus pandemic has brought about significant and unprecedented changes to the modern world, including stay-at-home orders, high rates of unemployment, and more than a hundred thousand deaths across the United States. Derived from the self-medication hypothesis, this research explored how perceived threat and psychological distress related to the COVID-19 pandemic are associated with drinking behavior among an American sample of adults. We also evaluated whether links between COVID-19-related perceived threat and psychological distress with drinking behavior are different for men and women. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106532DOI Listing

Leveraging genetic data to investigate molecular targets and drug repurposing candidates for treating alcohol use disorder and hepatotoxicity.

Drug Alcohol Depend 2020 Jul 2;214:108155. Epub 2020 Jul 2.

Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, United States; Medication Development Program, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, United States; Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, RI, United States.

Background: Novel treatments for alcohol use disorder (AUD) and alcohol-related liver disease (ALD) are greatly needed. Genetic information can improve drug discovery rates by facilitating the identification of novel biological targets and potential drugs for repurposing.

Methods: The present study utilized a recently developed Bayesian approach, Integrative Risk Gene Selector (iRIGS), to identify additional risk genes for alcohol consumption using SNPs from the largest alcohol consumption GWAS to date (N = 941,280). Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2020.108155DOI Listing

Quit ratios for cigarette smoking among individuals with opioid misuse and opioid use disorder in the United States.

Drug Alcohol Depend 2020 Jul 2;214:108164. Epub 2020 Jul 2.

Vermont Center on Behavior & Health, University of Vermont, Burlington, VT, United States. Electronic address:

Background: The prevalence of cigarette smoking is more than two times higher among individuals with versus without opioid misuse and/or opioid use disorders (OUD). Overall, smoking cessation has increased over time although it is unknown whether it has similarly increased for those with opioid misuse or OUD. The current study examined cigarette quit ratios from 2002 to 2018 among US individuals with and without opioid misuse or OUD. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2020.108164DOI Listing

Potential causes of male and female infertility in Qatar.

J Reprod Immunol 2020 Jun 28;141:103173. Epub 2020 Jun 28.

Department of Basic Medical Sciences, College of Medicine, Member of QU Health, Qatar University, Doha, Qatar. Electronic address:

A steady decline in the fertility rate has been observed in Qatar during the past fifty years. Therefore, infertility is considered a national priority in Qatar, a pronatalist society. This review article summarises the potential causes of infertility that are particularly prevalent in the Qatari population. Read More

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http://dx.doi.org/10.1016/j.jri.2020.103173DOI Listing

Revisiting the relationship between traffic accidents, real economic activity and other factors in Spain.

Accid Anal Prev 2020 Jul 8;144:105549. Epub 2020 Jul 8.

Universidad Autónoma de Madrid, Madrid, Spain.

This paper analyzes the relationship between road traffic accidents and real economic activity in Spain, using data on accidents, fatalities and injuries from January 1975 to December 2016. Our results show the historical asymmetric cyclical behavior of traffic accidents variables. This relationship is more evident for accidents and injuries, while fatalities have shown a different pattern since 2002. Read More

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http://dx.doi.org/10.1016/j.aap.2020.105549DOI Listing

The Role of Neutrophils in Mediating Stroke Injury in the Diabetic db/db Mouse Brain following Hypoxia-Ischemia.

Neurochem Int 2020 Jul 8:104790. Epub 2020 Jul 8.

Dept of Neural & Behavioral Sciences, College of Medicine, Penn State University, Hershey Medical Center, Hershey, PA, USA.

Diabetic mice exhibit increased mortality and morbidity following stroke. Recent studies from our laboratory have indicated that increased morbidity in diabetic db/db mice relative to their non-diabetic db/+ littermates is associated with increased levels of MMP-9 protease activity, increased blood-brain barrier (BBB) permeability, and greater neutrophil infiltration following hypoxic/ischemic (H/I) insult. Neutrophils are a major source of proteases and reactive oxygen species and studies have reported neutrophil depletion/inhibition is protective in certain models of experimental stroke. Read More

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http://dx.doi.org/10.1016/j.neuint.2020.104790DOI Listing

CORM-3 improves emotional changes induced by hemorrhagic shock via the inhibition of pyroptosis in the amygdala.

Neurochem Int 2020 Jul 8:104784. Epub 2020 Jul 8.

Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou, China. Electronic address:

Hemorrhagic shock and resuscitation (HSR) may lead to long-term neurological dysfunction, such as depression and anxiety. Carbon monoxide (CO) has emerged as an excellent neuroprotective agent against caspase-1-associated pyroptosis, following HSR. We evaluated the effects and determined the mechanism through which CO protects against emotional changes in a model of HSR, in rats. Read More

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http://dx.doi.org/10.1016/j.neuint.2020.104784DOI Listing

Amelioration of diabetes-induced cognitive impairment by Transient Receptor Potential Vanilloid 2 (TRPV2) channel inhibitor: Behavioral and mechanistic study.

Neurochem Int 2020 Jul 8:104783. Epub 2020 Jul 8.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S. A. S. Nagar, Punjab, India. Electronic address:

Transient receptor potential (TRP) channels are Ca permeable non-selective cation channels which play a pivotal role in diabetes and diabetic complications. Among diabetic complications, diabetes-induced cognitive impairment is a major CNS complication. The role of several TRP channels has been investigated extensively for their diverse Ca regulating mechanism, and recently their role has been postulated in the progression of neurodegenerative disorders. Read More

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http://dx.doi.org/10.1016/j.neuint.2020.104783DOI Listing

Subthreshold doses of guanosine plus ketamine elicit antidepressant-like effect in a mouse model of depression induced by corticosterone: Role of GR/NF-κB/IDO-1 signaling.

Neurochem Int 2020 Jul 8:104797. Epub 2020 Jul 8.

Neuroscience Postgraduate Program, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianópolis, 88040-900, SC, Brazil; Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianópolis, 88040-900, SC, Brazil. Electronic address:

Augmentative treatment is considered the best second-option when a first-choice drug has partial limitations, particularly by allowing antidepressant dose reduction. Considering that ketamine has significant knock-on effects, this study investigated the effects of single coadministration with subthreshold doses of ketamine plus guanosine in a corticosterone (CORT)-induced animal model of depression and the role of anti-inflammatory and antioxidant pathways. CORT administration (20 mg/kg, p. Read More

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http://dx.doi.org/10.1016/j.neuint.2020.104797DOI Listing

Degradation of an appetitive olfactory memory via devaluation of sugar reward is mediated by 5-HT signaling in the honey bee.

Neurobiol Learn Mem 2020 Jul 8:107278. Epub 2020 Jul 8.

College of Animal Science (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, China; Research Centre on Animal Cognition, Center for Integrative Biology, CNRS, University of Toulouse, 118 route de Narbonne, F-31062 Toulouse, France; Institut Universitaire de France (IUF). Electronic address:

Conditioned taste aversion (CTA) learning induces the devaluation of a preferred food through its pairing with a stimulus inducing internal illness. In invertebrates, it is still unclear how this aversive learning impairs the memories of stimuli that had been associated with the appetitive food prior to its devaluation. Here we studied this phenomenon in the honey bee and characterized its neural underpinnings. Read More

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http://dx.doi.org/10.1016/j.nlm.2020.107278DOI Listing

The Involvement of Notch1 Signaling Pathway in Mid-aged Female Rats under Chronic Restraint Stress.

Neurosci Lett 2020 Jul 8:135244. Epub 2020 Jul 8.

Research Center of Neurobiology, Fujian Medical University, Fuzhou 350122, Fujian Province, China. Electronic address:

Women are vulnerable to adverse stress events, especially during perimenopause. Substantial evidence has associated the impaired neuronal plasticity with abnormal behaviors under stressful conditions in animals. The Notch signaling pathway is critical for neuronal plasticity in the structure and function of brain areas. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135244DOI Listing

A Novel Method to Study Reward-Context Associations Paired With Drug-Seeking Behaviors.

J Neurosci Methods 2020 Jul 8:108857. Epub 2020 Jul 8.

Department of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA; Departments of Anesthesiology and Perioperative Medicine and Pharmacology, Penn State College of Medicine, Hershey, PA, 17033, USA. Electronic address:

Animal models have significantly contributed to the understanding of reward-related behaviors, such as in Substance Use Disorder research. One of the most heavily utilized paradigms to date is conditioned place preference (CPP). However CPP is limited by non-contingent exposure. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2020.108857DOI Listing

Enriched environment rearing from birth reduced anxiety, improved learning and memory, and promoted social interactions in adult male mice.

Neuroscience 2020 Jul 8. Epub 2020 Jul 8.

Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; School of Life Sciences, Peking-Tsinghua Center for Life Sciences, and Peking University McGovern Institute, Peking University, Beijing 100871, China. Electronic address:

Rearing rodents in an enriched environment (EE), with increased sensory stimulations and social interactions, is a well-established model for naturally increasing neural activity. It is well-known that EE-rearing of rodents from adolescence or during adulthood leads to extensive biochemical, morphological, electrophysiological and behavioral changes. Here, we examine the effects of EE-rearing from birth on adult behavior. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2020.07.004DOI Listing

In vivo assessment of cell death and nigrostriatal pathway integrity following continuous expression of C3 transferase.

Neuroscience 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurosurgery, United States. Electronic address:

The bacterial exoenzyme C3 transferase (C3) irreversibly inhibits RhoA GTPase leading to stimulation of axonal outgrowth in injured neurons. C3 has been used successfully in models of neurotrauma and shows promise as an option to support cell survival and axonal growth of dopaminergic neurons in Parkinson's disease cell therapy. Whether the continuous expression of C3 in dopaminergic neurons is well-tolerated is unknown. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2020.07.006DOI Listing

Social defeat stress in adolescent mice induces depressive-like behaviors with reduced oligodendrogenesis.

Neuroscience 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurophysiology and Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. Electronic address:

Strong stress related to adverse experiences during adolescence can cause mental disorders, as well as affecting brain structure and function. However, the underlying neurobiological mechanisms remain largely unknown. To investigate whether stress induced by adverse experience during adolescence affects oligodendrocyte (OL) remodeling, social defeat stress was applied to 6-week-old adolescent mice for 10 days, followed by behavioral tests and assessments of oligodendrogenesis. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2020.07.002DOI Listing

Barley β-glucan concentrate and its acid hydrolysate for the modification of dough making and rheological properties of water chestnut flour.

Int J Biol Macromol 2020 Jul 8. Epub 2020 Jul 8.

Department of Food Technology, Maharshi Dayanand University, Rohtak, Haryana, India.

β-Glucans are known for their beneficial physiological roles but can be used as potential food hydrocolloid. The present study was performed to assess the potential of barley β-glucan concentrates (native and partially hydrolyzed) in altering the functional properties of water chestnut flour dough. The β-glucan concentrate was subjected to partial hydrolysis to prepare a low molecular weight polymer. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.07.047DOI Listing

Deep Brain Stimulation of the Infralimbic Cortex Attenuates Cocaine Priming-Induced Reinstatement of Drug Seeking.

Brain Res 2020 Jul 8:147011. Epub 2020 Jul 8.

Center for Neurobiology and Behavior, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.

Deep brain stimulation (DBS) is a promising therapeutic modality for the treatment of drug craving and addiction. To date, the nucleus accumbens has received the most attention as a potential target region for examining the impact of DBS on cocaine seeking in preclinical models. The present study investigated the effects of DBS in brain regions that send major glutamatergic projections to the nucleus accumbens including the basolateral amygdala (BLA) and ventral hippocampus (vHipp) as well as subregions of the medial prefrontal cortex (mPFC) including the anterior cingulate, infralimbic and prelimbic cortices. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147011DOI Listing

Galantamine improves enhanced impulsivity, impairments of attention and long-term potentiation induced by prenatal nicotine exposure to mice.

Biochem Pharmacol 2020 Jul 8:114139. Epub 2020 Jul 8.

Advanced Diagnostic System Research Laboratory, Graduate School of Health Sciences, Fujita Health University, Toyoake, Japan; Japanese Drug Organization of Appropriate Use and Research, Nagoya, Japan.

Prenatal nicotine exposure (PNE) causes behavioral abnormalities in offspring, such as an enhancement of impulsivity and decrease in attention at adolescence. Here we examined the effects of galantamine (GAL) on the behavioral and electrophysiological changes induced by PNE in mice. Pregnant C57BL/6J mice were exposed to nicotine (0. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114139DOI Listing

Protective Effects of morin against depressive-like behavior prompted by chronic unpredictable mild stress in rats: Possible role of inflammasome-related pathways.

Biochem Pharmacol 2020 Jul 8:114140. Epub 2020 Jul 8.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Depression is a common mental illness that possesses a noteworthy effect on patients' lives. Many theories are recently studied for their plausible involvement in depression pathogenesis, especially oxidative stress and inflammation. Morin (2',3,4',5,7-pentahydroxyflavone), a natural flavonoid, is characterized by its potent anti-inflammatory, and anti-oxidant activities. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114140DOI Listing

Smartphone-based financial incentives to promote smoking cessation during pregnancy: A pilot study.

Prev Med 2020 Jul 8:106201. Epub 2020 Jul 8.

Vermont Center on Behavior and Health, University of Vermont, Burlington, VT, USA; Departments of Psychiatry, University of Vermont, Burlington, VT, USA; Psychological Science, University of Vermont, Burlington, VT, USA.

Cigarette smoking during pregnancy increases risk for pregnancy complications, growth restriction, and other adverse health outcomes. The most effective intervention for reducing smoking during pregnancy is financial incentives contingent on biochemically-verified smoking abstinence. The present study examined the efficacy of a smartphone-based intervention whereby smoking monitoring and incentive delivery occurred remotely using a mobile app. Read More

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http://dx.doi.org/10.1016/j.ypmed.2020.106201DOI Listing

Longitudinal trends in nonmedical prescription opioid use in a cohort of rural Appalachian people who use drugs.

Prev Med 2020 Jul 8:106194. Epub 2020 Jul 8.

Center on Drug and Alcohol Use, University of Kentucky College of Medicine, United States of America; Department of Behavioral Science, University of Kentucky College of Medicine, United States of America.

Rural Appalachia remains an epicenter of the prescription opioid epidemic. In 2008, a cohort study was undertaken to examine longitudinal trends in nonmedical prescription opioid use (NMPOU). Eight waves of data (2008-2020) from the Social Networks among Appalachian People (SNAP) cohort were utilized for the current analysis. Read More

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http://dx.doi.org/10.1016/j.ypmed.2020.106194DOI Listing

The mediating role of school connectedness in the associations between dating and sexual violence victimization and substance use among high school students.

Prev Med 2020 Jul 8:106197. Epub 2020 Jul 8.

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, United States of America.

Dating and sexual violence victimization affect a significant portion of teenagers and result in a wide array of negative health and behavioral outcomes, including increased alcohol and drug use. In some cases, students who have been victimized may develop feelings of being unsupported by or disconnected from peers and adults in their school community, placing them at even higher risk for negative health outcomes. Using a prospective design, the present study sought to explore this possibility by examining the direct and indirect associations between dating violence (DV) and sexual violence (SV) victimization, school connectedness, and alcohol and marijuana use at baseline (T1) and 2-month follow-up (T2) in a sample of high school students (N = 1752). Read More

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http://dx.doi.org/10.1016/j.ypmed.2020.106197DOI Listing

The role of advanced and late provisions in a co-evolutionary epidemic game model for assessing the social triple-dilemma aspect.

J Theor Biol 2020 Jul 8:110399. Epub 2020 Jul 8.

Faculty of Engineering Sciences, Kyushu University, Kasuga-koen, Kasuga-shi, Fukuoka 816-8580, Japan; Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga-koen, Kasuga-shi, Fukuoka 816-8580, Japan.

In the context of voluntary vaccination, we consider two additional provisions as well as pre-emptive vaccination for a unified model over epidemiology and evolutionary game theory to assess the extent to which advanced and late provisions restrict the spread of disease. To circumvent infection, people can be vaccinated pre-emptively before the epidemic season, but the imperfectness of vaccination or an unwillingness to be vaccinated may cause people instead to either be late-vaccinated or use self-protection. Here, self-protection corresponds to actions such as wearing a mask, washing hands, or using a mosquito net and is defined as the third strategy after pre-emptive vaccination (the first strategy) and late-vaccination (the second strategy). Read More

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http://dx.doi.org/10.1016/j.jtbi.2020.110399DOI Listing

Fluoxetine rescues rotarod motor deficits in Mecp2 heterozygous mouse model of rett syndrome via brain serotonin.

Neuropharmacology 2020 Jul 8:108221. Epub 2020 Jul 8.

Laboratory of Neurochemistry and Behavior, Department of Neuroscience, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, Milano, Italy. Electronic address:

Motor skill is a specific area of disability of Rett syndrome (RTT), a rare disorder occurring almost exclusively in girls, caused by loss-of-function mutations of the X-linked methyl-CpG-binding protein2 (MECP2) gene, encoding the MECP2 protein, a member of the methyl-CpG-binding domain nuclear proteins family. Brain 5-HT, which is defective in RTT patients and Mecp2 mutant mice, regulates motor circuits and SSRIs enhance motor skill learning and plasticity. In the present study, we used heterozygous (Het) Mecp2 female and Mecp2-null male mice to investigate whether fluoxetine, a SSRI with pleiotropic effects on neuronal circuits, rescues motor coordination deficits. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2020.108221DOI Listing

An Investigation of Human-Mosquito Contact Using Surveys and Its Application in Assessing Dengue Viral Transmission Risk.

J Med Entomol 2020 Jul 11. Epub 2020 Jul 11.

Department of Tropical Medicine, Tulane University, New Orleans, LA.

Aedes-borne viral diseases such as dengue fever are surging in incidence in recent years. To investigate viral transmission risks, the availability of local transmission parameters is essential. One of the most important factors directly determining infection risk is human-mosquito contact. Read More

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http://dx.doi.org/10.1093/jme/tjaa134DOI Listing

Infants with big appetites: The role of a nonfood environment on infant appetitive traits linked to obesity.

Am J Clin Nutr 2020 Jul 11. Epub 2020 Jul 11.

Division of Behavioral Medicine, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.

Background: Individual differences in appetitive traits present in the first few weeks of life. Research has shown that infants with a greater food reinforcement ratio (FRR) have higher obesity risk. To date, limited work has examined the relation between FRR and appetitive traits of infants, and how FRR relates to appetitive traits and obesity development. Read More

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http://dx.doi.org/10.1093/ajcn/nqaa175DOI Listing

A Chicken Production Intervention and Additional Nutrition Behavior Change Component Increased Child Growth in Ethiopia: A Cluster-Randomized Trial.

J Nutr 2020 Jul 11. Epub 2020 Jul 11.

Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA.

Background: Chicken production in the context of nutrition-sensitive agriculture may benefit child nutrition in low-income settings.

Objectives: This study evaluated effects of 1) a chicken production intervention [African Chicken Genetic Gains (ACGG)], and 2) the ACGG intervention with nutrition-sensitive behavior change communication (BCC) [ACGG + Agriculture to Nutrition (ATONU)], on child nutrition and health outcomes and hypothesized intermediaries.

Methods: Forty ACGG villages received 25 genetically improved chickens and basic husbandry guidance; of these, 20 ACGG + ATONU villages in addition received a nutrition-sensitive behavior change and homegardening intervention; 20 control clusters received no intervention. Read More

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http://dx.doi.org/10.1093/jn/nxaa181DOI Listing

Beyond description: the many facets of dental biomechanics.

Integr Comp Biol 2020 Jul 11. Epub 2020 Jul 11.

Department of Evolution, Ecology, and Behavior, University of Illinois, Urbana Champaign, 515 Morrill Hall, 505 S Goodwin Ave, Urbana, IL.

Teeth lie at the interface between an animal and its environment and, with some exceptions, act as a major component of resource procurement through food acquisition and processing. Therefore, the shape of a tooth is closely tied to the type of food being eaten. This tight relationship is of use to biologists describing the natural history of species and given the high instance of tooth preservation in the fossil record, is especially useful for paleontologists. Read More

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http://dx.doi.org/10.1093/icb/icaa103DOI Listing

Protective Effects of Spermidine and Melatonin on Deltamethrin-Induced Cardiotoxicity and Neurotoxicity in Zebrafish.

Cardiovasc Toxicol 2020 Jul 10. Epub 2020 Jul 10.

State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, China.

Increased application of the pyrethroid insecticide deltamethrin has adverse effects on the cardiac system and neurobehavior on the non-target organisms, which has raised the public's attention. Because of spermidine and melatonin considered to have cardioprotective and neuroprotective characteristics, zebrafish were utilized as the model organism to explore the protective effects of spermidine and melatonin against deltamethrin-induced toxicity. We tested the neurobehavior of zebrafish larvae through a rest/wake behavior assay, and evaluated the levels of the expression of Scn5lab, gata4, nkx2. Read More

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http://dx.doi.org/10.1007/s12012-020-09591-5DOI Listing

Design and Application of Light-Regulated Receptor Tyrosine Kinases.

Methods Mol Biol 2020 ;2173:233-246

Australian Regenerative Medicine Institute (ARMI), Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia.

Understanding how the activity of membrane receptors and cellular signaling pathways shapes cell behavior is of fundamental interest in basic and applied research. Reengineering receptors to react to light instead of their cognate ligands allows for generating defined signaling inputs with high spatial and temporal precision and facilitates the dissection of complex signaling networks. Here, we describe fundamental considerations in the design of light-regulated receptor tyrosine kinases (Opto-RTKs) and appropriate control experiments. Read More

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http://dx.doi.org/10.1007/978-1-0716-0755-8_16DOI Listing
January 2020
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