2,521 results match your criteria Behavior genetics[Journal]


A Comparison of the ASEBA Adult Self Report (ASR) and the Brief Problem Monitor (BPM/18-59).

Behav Genet 2020 May 17. Epub 2020 May 17.

Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.

The adult self report (ASR) is a well-validated instrument with multiple scales relating to adult psychopathology. Recently, an 18-item version has been introduced, the brief problem monitor (BPM) to measure Internalizing behavior (INT), Externalizing behavior (EXT), and attention problems (ATT). The present study compared the BPM and ASR and investigated how well the BPM can serve as a supplement or an alternative for the ASR for specific clinical and scientific purposes. Read More

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http://dx.doi.org/10.1007/s10519-020-10001-3DOI Listing

Separating Measured Genetic and Environmental Effects: Evidence Linking Parental Genotype and Adopted Child Outcomes.

Behav Genet 2020 Apr 30. Epub 2020 Apr 30.

La Follette School of Public Affairs, Department of Sociology, and Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, USA.

There has been widespread adoption of genome wide summary scores (polygenic scores) as tools for studying the importance of genetics and associated life course mechanisms across a range of demographic and socioeconomic outcomes. However, an often unacknowledged issue with these studies is that parental genetics impact both child environments and child genetics, leaving the effects of polygenic scores difficult to interpret. This paper uses multi-generational data containing polygenic scores for parents (n = 7193) and educational outcomes for adopted (n = 855) and biological (n = 20,939) children, many raised in the same families, which allows us to separate the influence of parental polygenic scores on children outcomes between environmental (adopted children) and environmental and genetic (biological children) effects. Read More

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http://dx.doi.org/10.1007/s10519-020-10000-4DOI Listing

A Family-Based Genome Wide Association Study of Externalizing Behaviors.

Behav Genet 2020 May 1;50(3):175-183. Epub 2020 Apr 1.

Department of Psychology, Virginia Commonwealth University, 8 North Harrison St, Richmond, VA, 23284, USA.

Shared genetic factors contribute to the high degree of comorbidity among externalizing problems (e.g. substance use and antisocial behavior). Read More

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http://dx.doi.org/10.1007/s10519-020-09999-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243710PMC
May 2020
3.210 Impact Factor

A Twin Study of Inhibitory Control at Age Two and ADHD Behavior Problems at Age Three.

Behav Genet 2020 Mar 11. Epub 2020 Mar 11.

Boston University, Boston, USA.

Low levels of childhood inhibitory control (IC) are phenotypically and genetically associated with externalizing behavior problems and attention deficit hyperactivity disorder (ADHD). Unfortunately, there is little research on this topic in early childhood, when IC first emerges. This investigation extends the previous findings of contemporaneous genetic covariance between parent-rated and laboratory-assessed IC and ADHD at age 2 by examining longitudinal links between IC at age two and ADHD behavior problems at age three in a sample of 314 same-sex twin pairs (145 monozygotic or MZ, 169 dizygotic or DZ). Read More

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http://dx.doi.org/10.1007/s10519-020-09997-5DOI Listing

Correction to: The Association of Oxytocin Receptor Gene (OXTR) Polymorphisms with Antisocial Behavior: A Meta-analysis.

Behav Genet 2020 May;50(3):174

Department of Psychology, Emory University, 36 Eagle Row, Atlanta, GA, 30322, USA.

The original version of this article inadvertently omitted the word "with" between "Polymorphisms" and "Antisocial" from the title. The title "The Association of Oxytocin Receptor Gene (OXTR) Polymorphisms Antisocial Behavior: A Meta-Analysis" should be "The Association of Oxytocin Receptor Gene (OXTR) Polymorphisms with Antisocial Behavior: A Meta-Analysis." as presented above. Read More

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http://dx.doi.org/10.1007/s10519-020-09998-4DOI Listing

The Association of Oxytocin Receptor Gene (OXTR) Polymorphisms Antisocial Behavior: A Meta-analysis.

Behav Genet 2020 May 14;50(3):161-173. Epub 2020 Feb 14.

Department of Psychology, Emory University, 36 Eagle Row, Atlanta, GA, 30322, USA.

Evidence suggests that the Oxytocin Receptor Gene (OXTR) influences human social cognition and behavior. OXTR has been investigated in relation to antisocial behavior, but studies examining this association have produced varying results in terms of the magnitude and significance of the association as well as which SNPs are implicated. This meta-analysis, based on 15 samples in 12 studies with a total sample of 12,236 individuals, examined the overall effects and consistency of associations between eight SNPs in OXTR and antisocial behavior. Read More

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http://dx.doi.org/10.1007/s10519-020-09996-6DOI Listing

Hyperactivity, Memory Defects, and Craniofacial Abnormalities in Zebrafish fmr1 Mutant Larvae.

Behav Genet 2020 May 12;50(3):152-160. Epub 2020 Feb 12.

CAS Key Lab of Bio-medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, Jiangsu, People's Republic of China.

Fragile X syndrome (FXS) is a heritable mental retardation disease caused by unstable trinucleotide repeat sequences in FMR1. FXS is characterized by delayed development, hyperactivity, and autism behavior. Zebrafish is an excellent model to study FXS and the underlying function of fmr1. Read More

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http://dx.doi.org/10.1007/s10519-020-09995-7DOI Listing

A Simulation Study of Bootstrap Approaches to Estimate Confidence Intervals in DeFries-Fulker Regression Models (with Application to the Heritability of BMI Changes in the NLSY).

Behav Genet 2020 03 10;50(2):127-138. Epub 2020 Feb 10.

Department of Psychology and Human Development, Peabody College, Vanderbilt University, Nashville, TN, USA.

The univariate bootstrap is a relatively recently developed version of the bootstrap (Lee and Rodgers in Psychol Methods 3(1): 91, 1998). DeFries-Fulker (DF) analysis is a regression model used to estimate parameters in behavioral genetic models (DeFries and Fulker in Behav Genet 15(5): 467-473, 1985). It is appealing for its simplicity; however, it violates certain regression assumptions such as homogeneity of variance and independence of errors that make calculation of standard errors and confidence intervals problematic. Read More

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http://dx.doi.org/10.1007/s10519-020-09993-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065829PMC

Adolescent Externalizing Psychopathology and Its Prospective Relationship to Marijuana Use Development from Age 14 to 30: Replication Across Independent Longitudinal Twin Samples.

Behav Genet 2020 May 8;50(3):139-151. Epub 2020 Feb 8.

Department of Psychology, University of Minnesota, Twin Cities, N218 Elliott Hall, 75 East River Parkway, Minneapolis, MN, 55455, USA.

Externalizing psychopathology in early adolescence is a highly heritable risk factor for drug use, yet how it relates to marijuana use development is not well-characterized. We evaluate this issue in independent twin samples from Colorado (N = 2608) and Minnesota (N = 3630), assessed from adolescence to early adulthood. We used a biometric latent growth model of marijuana use frequency with data from up to five waves of assessment from ages 14 to 30, to examine change in marijuana use and its relationship with a factor model of adolescent externalizing psychopathology. Read More

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http://dx.doi.org/10.1007/s10519-020-09994-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202952PMC

Neurofibromatosis Type 1 Implicates Ras Pathways in the Genetic Architecture of Neurodevelopmental Disorders.

Behav Genet 2020 Feb 5. Epub 2020 Feb 5.

Office of the Clinical Director and Medical Genetic Branch, National Human Genome Research Institute, National Institute of Health, Bethesda, MD, USA.

The genetic architecture of neurodevelopmental disorders is largely polygenic, non-specific, and pleiotropic. This complex genetic architecture makes the search for specific etiological mechanisms that contribute to neurodevelopmental risk more challenging. Monogenic disorders provide an opportunity to focus in on how well-articulated signaling pathways contribute to risk for neurodevelopmental outcomes. Read More

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http://dx.doi.org/10.1007/s10519-020-09991-xDOI Listing
February 2020

Intergenerational Transmission of Education and ADHD: Effects of Parental Genotypes.

Behav Genet 2020 Feb 6. Epub 2020 Feb 6.

Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 7-9, 1081 BT, Amsterdam, The Netherlands.

It remains a challenge to determine whether children resemble their parents due to nature, nurture, or a mixture of both. Here we used a design that exploits the distinction between transmitted and non-transmitted alleles in genetic transmission from parent to offspring. Two separate polygenic scores (PGS) were calculated on the basis of the transmitted and non-transmitted alleles. Read More

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http://dx.doi.org/10.1007/s10519-020-09992-wDOI Listing
February 2020

An Extended Twin-Pedigree Study of Different Classes of Voluntary Exercise Behavior.

Behav Genet 2020 03 23;50(2):94-104. Epub 2020 Jan 23.

Department of Biological Psychology, Netherlands Twin Registry, Vrije Universiteit, Van der Boechorststraat 7, 1081BT, Amsterdam, The Netherlands.

We investigated the familial clustering of different classes of voluntary regular exercise behavior in extended twin-family pedigrees. In contrast to the earlier work based on twin data only, this allowed us to estimate the contributions of shared household effects (C), additive (A), and non-additive (D) genetic effects on voluntary exercise behavior. To test whether shared household effects were inflated by assortative mating we examined the causes of spousal resemblance. Read More

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http://dx.doi.org/10.1007/s10519-019-09990-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028831PMC

Quantile-Specific Heritability may Account for Gene-Environment Interactions Involving Coffee Consumption.

Authors:
Paul T Williams

Behav Genet 2020 03 3;50(2):119-126. Epub 2020 Jan 3.

Molecular Biophysics & Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA, 94720, USA.

Estimated heritability of coffee intake ranges from 0.36 to 0.58, however, these point estimates assume that inherited effects are the same throughout the distribution of coffee intake, i. Read More

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http://dx.doi.org/10.1007/s10519-019-09989-0DOI Listing

On the Nature of Monozygotic Twin Concordance and Discordance for Autistic Trait Severity: A Quantitative Analysis.

Behav Genet 2019 Dec 18. Epub 2019 Dec 18.

Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.

The characterizing features of autism spectrum disorder (ASD) are continuously distributed in nature; however, prior twin studies have not systematically incorporated this knowledge into estimations of concordance and discordance. We conducted a quantitative analysis of twin-twin similarity for autistic trait severity in three existing data sets involving 366 pairs of uniformly-phenotyped monozygotic (MZ) twins with and without ASD. Probandwise concordance for ASD was 96%; however, MZ trait correlations differed markedly for pairs with ASD trait burden below versus above the threshold for clinical diagnosis, with Rs on the order of 0. Read More

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http://dx.doi.org/10.1007/s10519-019-09987-2DOI Listing
December 2019
3.210 Impact Factor

Using Genetics to Examine a General Liability to Childhood Psychopathology.

Behav Genet 2019 Dec 11. Epub 2019 Dec 11.

Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Hadyn Ellis Building, Maindy Road, Cathays, Cardiff, CF24 4HQ, UK.

Psychiatric disorders show phenotypic as well as genetic overlaps. There are however also marked developmental changes throughout childhood. We investigated the extent to which, for a full range of early childhood psychopathology, a general "p" factor was explained by genetic liability, as indexed by multiple different psychiatric polygenic risk scores (PRS) and whether these relationships altered with age. Read More

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http://dx.doi.org/10.1007/s10519-019-09985-4DOI Listing
December 2019

Midlife Study of the Louisville Twins: Connecting Cognitive Development to Biological and Cognitive Aging.

Behav Genet 2020 03 9;50(2):73-83. Epub 2019 Dec 9.

Department of Pediatrics, University of Louisville, Louisville, KY, USA.

The Louisville Twin Study (LTS) began in 1958 and became a premier longitudinal twin study of cognitive development. The LTS continuously collected data from twins through 2000 after which the study closed indefinitely due to lack of funding. Now that the majority of the sample is age 40 or older (61. Read More

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http://dx.doi.org/10.1007/s10519-019-09983-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033012PMC

The Association Between Somatic Health, Autism Spectrum Disorder, and Autistic Traits.

Behav Genet 2019 Dec 6. Epub 2019 Dec 6.

Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Gävlegatan 22, 11330, Stockholm, Sweden.

This study used a twin cohort to investigate the association of autism spectrum disorder (ASD) and autistic traits with somatic health. A total of 344 twins (172 pairs; mean age 15.56 ± 5. Read More

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http://dx.doi.org/10.1007/s10519-019-09986-3DOI Listing
December 2019

A Genetic Cross-Lagged Study of the Longitudinal Association Between Anxiety and Depressive Symptoms During Childhood.

Behav Genet 2020 03 6;50(2):105-118. Epub 2019 Dec 6.

École de Psychologie, Université Laval, Quebec City, Canada.

This study documented the etiology contributions between anxiety symptoms (AS) and depressive symptoms (DS) from ages 6-12 years. Teachers assessed AS and DS in 1112 twins at 5 time points. A genetic cross-lagged model was used to estimate genetic/environmental contributions to cross-sectional, cross-age and cross-lag associations. Read More

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http://dx.doi.org/10.1007/s10519-019-09988-1DOI Listing

Familial Influences on Neuroticism and Education in the UK Biobank.

Behav Genet 2020 03 4;50(2):84-93. Epub 2019 Dec 4.

Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 de Crespigny Park, Denmark Hill, London, SE5 8AF, UK.

Genome-wide studies often exclude family members, even though they are a valuable source of information. We identified parent-offspring pairs, siblings and couples in the UK Biobank and implemented a family-based DNA-derived heritability method to capture additional genetic effects and multiple sources of environmental influence on neuroticism and years of education. Compared to estimates from unrelated individuals, total heritability increased from 10 to 27% and from 17 to 56% for neuroticism and education respectively by including family-based genetic effects. Read More

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http://dx.doi.org/10.1007/s10519-019-09984-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028797PMC

Pathways Between a Polygenic Score for Educational Attainment and Higher Educational Attainment in an African American Sample.

Behav Genet 2020 01 23;50(1):14-25. Epub 2019 Nov 23.

New Mexico VA Health Care System, Las Vegas, USA.

We investigated the extent to which performance on standardized achievement tests, executive function (EF), and aggression in childhood and adolescence accounted for the relationship between a polygenic score for educational attainment (EA PGS) and years of education in a community sample of African Americans. Participants (N = 402; 49.9% female) were initially recruited for an elementary school-based prevention trial in a Mid-Atlantic city and followed into adulthood. Read More

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http://dx.doi.org/10.1007/s10519-019-09982-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942631PMC
January 2020

Interaction Between Odor Identification Deficit and APOE4 Predicts 6-Year Cognitive Decline in Elderly Individuals.

Behav Genet 2020 01 23;50(1):3-13. Epub 2019 Nov 23.

Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.

Olfactory identification impairment might indicate future cognitive decline in elderly individuals. An unresolved question is to what extent this effect is dependent on the ApoE-ε4, a genotype associated with risk of Alzheimer's Disease (AD). Given the current concern about reproducibility in empirical research, we assessed this issue in a large sample (n = 1637) of older adults (60 - 96 years) from the population-based longitudinal Swedish National Study on Aging and Care in Kungsholmen (SNAC-K). Read More

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http://dx.doi.org/10.1007/s10519-019-09980-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941999PMC
January 2020

Celebrating the 50th Anniversary of the Journal, Behavior Genetics.

Authors:
John K Hewitt

Behav Genet 2020 01;50(1):1-2

Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, USA.

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http://dx.doi.org/10.1007/s10519-019-09981-8DOI Listing
January 2020

No Evidence for Social Genetic Effects or Genetic Similarity Among Friends Beyond that Due to Population Stratification: A Reappraisal of Domingue et al (2018).

Behav Genet 2020 01 11;50(1):67-71. Epub 2019 Nov 11.

School of Psychology, The University of Queensland, Brisbane, 4072, Australia.

Using data from 5500 adolescents from the National Longitudinal Study of Adolescent to Adult Health, Domingue et al. (Proc Natl Acad Sci 25:256., 2018) claimed to show that friends are genetically more similar to one another than randomly selected peers, beyond the confounding effects of population stratification by ancestry. Read More

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http://dx.doi.org/10.1007/s10519-019-09979-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077882PMC
January 2020

Behavior Genetics Association 49th Annual Meeting Abstracts.

Authors:

Behav Genet 2019 Oct 22:487-557. Epub 2019 Oct 22.

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http://dx.doi.org/10.1007/s10519-019-09973-8DOI Listing
October 2019

Carol Becker Lynch (1942-2019).

Authors:

Behav Genet 2019 11;49(6):485-486

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http://dx.doi.org/10.1007/s10519-019-09972-9DOI Listing
November 2019

Construct Validity and Cross Validity of a Test Battery Modeling Autism Spectrum Disorder (ASD) in Mice.

Behav Genet 2020 01 21;50(1):26-40. Epub 2019 Sep 21.

Aix Marseille Univ, CNRS, LPC, Marseille, France.

Modeling in other organism species is one of the crucial stages in ascertaining the association between gene and psychiatric disorder. Testing Autism Spectrum Disorder (ASD) in mice is very popular but construct validity of the batteries is not available. We presented here the first factor analysis of a behavioral model of ASD-like in mice coupled with empirical validation. Read More

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http://dx.doi.org/10.1007/s10519-019-09970-xDOI Listing
January 2020

A Novel Model to Explain Extreme Feather Pecking Behavior in Laying Hens.

Behav Genet 2020 01 20;50(1):41-50. Epub 2019 Sep 20.

Institute of Animal Science, University of Hohenheim, Garbenstr. 17, 70593, Stuttgart, Germany.

Feather pecking (FP) is a serious economic and welfare problem in the domestic fowl. It has recently been shown that the distribution of FP bouts within groups is heterogeneous and contains a sub-population of extreme feather peckers (EFP). The present study proposed a novel model to detect EFP hens. Read More

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http://dx.doi.org/10.1007/s10519-019-09971-wDOI Listing
January 2020

Genetic and Environmental Influences on Different Forms of Bullying Perpetration, Bullying Victimization, and Their Co-occurrence.

Behav Genet 2019 09 10;49(5):432-443. Epub 2019 Sep 10.

Department of Biological Psychology, Vrije Universiteit Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.

Bullying comes in different forms, yet most previous genetically-sensitive studies have not distinguished between them. Given the serious consequences and the high prevalence of bullying, it is remarkable that the aetiology of bullying and its different forms has been under-researched. We present the first study to investigate the genetic architecture of bullying perpetration, bullying victimization, and their co-occurrence for verbal, physical and relational bullying. Read More

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http://dx.doi.org/10.1007/s10519-019-09968-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768918PMC
September 2019
1 Read

Introducing M-GCTA a Software Package to Estimate Maternal (or Paternal) Genetic Effects on Offspring Phenotypes.

Behav Genet 2020 01 6;50(1):51-66. Epub 2019 Sep 6.

University of Queensland Diamantina Institute, University of Queensland, Brisbane, QLD, Australia.

There is increasing interest within the genetics community in estimating the relative contribution of parental genetic effects on offspring phenotypes. Here we describe the user-friendly M-GCTA software package used to estimate the proportion of phenotypic variance explained by maternal (or alternatively paternal) and offspring genotypes on offspring phenotypes. The tool requires large studies where genome-wide genotype data are available on mother- (or alternatively father-) offspring pairs. Read More

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http://dx.doi.org/10.1007/s10519-019-09969-4DOI Listing
January 2020
2 Reads

Responding to a 100-Year-Old Challenge from Fisher: A Biometrical Analysis of Adult Height in the NLSY Data Using Only Cousin Pairs.

Behav Genet 2019 09 7;49(5):444-454. Epub 2019 Aug 7.

Virginia Commonwealth University, Richmond, USA.

In 1918, Fisher suggested that his research team had consistently found inflated cousin correlations. He also commented that because a cousin sample with minimal selection bias was not available the cause of the inflation could not be addressed, leaving this inflation as a challenge still to be solved. In the National Longitudinal Survey of Youth (the NLSY79, the NLSY97, and the NLSY-Children/Young Adult datasets), there are thousands of available cousin pairs. Read More

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http://dx.doi.org/10.1007/s10519-019-09967-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778682PMC
September 2019

Differential Influences of Genes and Environment Across the Distribution of Reading Ability.

Behav Genet 2019 09 5;49(5):425-431. Epub 2019 Aug 5.

Department of Psychology, University of New England, Library Rd, Armidale, NSW, 2350, Australia.

We partitioned early childhood reading into genetic and environmental sources of variance and examined the full distribution of ability levels from low through normal to high as computed by quantile regression. The full sample comprised twin pairs measured at preschool (n = 977), kindergarten (n = 1028), grade 1 (n = 999), and grade 2 (n = 1000). Quantile regression analyses of the full distribution of literacy ability showed genetic influence in all grades from preschool to grade 2. Read More

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http://dx.doi.org/10.1007/s10519-019-09966-7DOI Listing
September 2019

Psychiatric Polygenic Risk Scores as Predictor for Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in a Clinical Child and Adolescent Sample.

Behav Genet 2019 Jul 25. Epub 2019 Jul 25.

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, The Netherlands.

Neurodevelopmental disorders such as attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable and influenced by many single nucleotide polymorphisms (SNPs). SNPs can be used to calculate individual polygenic risk scores (PRS) for a disorder. We aim to explore the association between the PRS for ADHD, ASD and for Schizophrenia (SCZ), and ADHD and ASD diagnoses in a clinical child and adolescent population. Read More

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http://dx.doi.org/10.1007/s10519-019-09965-8DOI Listing
July 2019
1 Read

Public Understanding of Behavioral Genetics: Integrating Heuristic Thinking, Motivated Reasoning and Planned Social Change Theories for Better Communication Strategies.

Behav Genet 2019 09 17;49(5):469-477. Epub 2019 Jul 17.

Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

The field of behavioral genetics is experiencing a revolution following the development of genome-wide association studies and the availability of large datasets from international consortia. This rapid change could increase the existing gaps between basic research, translation, and public understanding of science. In the present work, we aim to synthesize key explanations of how public understanding of socio-scientific issues develop. Read More

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http://dx.doi.org/10.1007/s10519-019-09964-9DOI Listing
September 2019

Correction to: Genetics of Perceived Family Interaction From 12 to 17 Years of Age.

Behav Genet 2019 Sep;49(5):484

Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland.

The article "Genetics of Perceived Family Interaction From 12 to 17 Years of Age", written by Karri Silventoinen, Jinni Su, Lea Pulkkinen, Peter Barr, Richard J. Rose, Danielle M. Dick, Jaakko Kaprio, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 24 May 2019 without open access. Read More

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http://dx.doi.org/10.1007/s10519-019-09963-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768905PMC
September 2019
1 Read
3.210 Impact Factor

Arousal from Tonic Immobility by Vibration Stimulus.

Behav Genet 2019 09 21;49(5):478-483. Epub 2019 Jun 21.

Faculty of Computer Science and Engineering, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto, Japan.

Tonic immobility (TI) is an effective anti-predator strategy. However, long immobility status on the ground increases the risk of being eaten by predators, and thus insects must rouse themselves when appropriate stimulation is provided. Here, the strength of vibration causing arousal from the state of TI was examined in strains artificially selected for longer duration of TI (L-strains: long sleeper) in a beetle. Read More

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http://dx.doi.org/10.1007/s10519-019-09962-xDOI Listing
September 2019
5 Reads

Cognitive Performance in Young APOE ε4 Carriers: A Latent Variable Approach for Assessing the Genotype-Phenotype Relationship.

Behav Genet 2019 09 8;49(5):455-468. Epub 2019 Jun 8.

Department of Physics, Centre for Nonlinear Studies, Institute of Computational and Theoretical Studies, Hong Kong Baptist University, Cha Chi-Ming Science Tower, Kowloon Tong, Hong Kong.

The ε4 allele of the apolipoprotein (APOE) gene is a widely recognized genetic risk factor for developing Alzheimer's disease in older age. However, it is controversial whether there is a positive impact of the APOE ε4 allele on human cognitive performance in young adulthood, possibly representing a case of antagonistic pleiotropy. Here we explored associations of the APOE ε4 allele with cognitive ability in young adulthood. Read More

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http://dx.doi.org/10.1007/s10519-019-09961-yDOI Listing
September 2019
1 Read

Significance of IL-6 Deficiency in Recognition Memory in Young Adult and Aged Mice.

Behav Genet 2019 07 25;49(4):415-423. Epub 2019 May 25.

Department of General and Experimental Pathology, Medical University of Białystok, Mickiewicza 2c, 15-222, Białystok, Poland.

Chronic peripheral elevation of interleukin 6 (IL-6) in humans is associated with cognitive deficits. 4- and 24-month-old IL-6-deficient C57BL/6J (IL-6KO) and reference wild-type (WT) mice were tested in an object recognition test. Discrimination ratios and recognition indexes were significantly lower in 4-month-old IL-6KO and in 24-month-old WT mice vs 4-month-old WT animals. Read More

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http://link.springer.com/10.1007/s10519-019-09959-6
Publisher Site
http://dx.doi.org/10.1007/s10519-019-09959-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554246PMC
July 2019
2 Reads

Genetics of Perceived Family Interaction From 12 to 17 Years of Age.

Behav Genet 2019 07 24;49(4):366-375. Epub 2019 May 24.

Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland.

We analyzed how the effects of genetic and environmental factors on the perceptions of family interaction change from early to late adolescence. The data were collected by postal surveys on Finnish twins (N = 4808) at 12, 14 and 17 years of age and analyzed using genetic twin modeling. Additive genetic factors explained a modest share of the variation in perceived relational support (a = 0. Read More

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http://link.springer.com/10.1007/s10519-019-09960-z
Publisher Site
http://dx.doi.org/10.1007/s10519-019-09960-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554250PMC
July 2019
14 Reads
3.210 Impact Factor

Systematic Review of Polygenic Gene-Environment Interaction in Tobacco, Alcohol, and Cannabis Use.

Behav Genet 2019 07 20;49(4):349-365. Epub 2019 May 20.

Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.

Studies testing the effect of single genetic variants on substance use have had modest success. This paper reviewed 39 studies using polygenic measures to test interaction with any type of environmental exposure (G×E) in alcohol, tobacco, and cannabis use. Studies using haplotype combinations, sum scores of candidate-gene risk alleles, and polygenic scores (PS) were included. Read More

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http://dx.doi.org/10.1007/s10519-019-09958-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554261PMC
July 2019
2 Reads

Exome Sequencing of Two Siblings with Sporadic Autism Spectrum Disorder and Severe Speech Sound Disorder Suggests Pleiotropic and Complex Effects.

Behav Genet 2019 07 4;49(4):399-414. Epub 2019 Apr 4.

Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.

Recent studies of autism spectrum disorder (ASD) and childhood apraxia of speech (CAS) have resulted in conflicting conclusions regarding the comorbidity of these disorders on phenotypic grounds. In a nuclear family with two dually affected and one unaffected offspring, whole-exome sequences were evaluated for single nucleotide and indel variants and CNVs. The affected siblings but not the unaffected sibling share a rare deleterious compound heterozygous mutation in WWOX, implicated both in ASD and motor control. Read More

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http://link.springer.com/10.1007/s10519-019-09957-8
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http://dx.doi.org/10.1007/s10519-019-09957-8DOI Listing
July 2019
19 Reads

Correction to: A Genetic Investigation of the Well-Being Spectrum.

Behav Genet 2019 May;49(3):298

Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.

In the original version of this article, unfortunately, in the acknowledgement section "National Institutes of Health (NIH, R37 AG033590-08) to J Cacioppo" was omitted. This has been corrected by publishing this erratum. Read More

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http://dx.doi.org/10.1007/s10519-019-09956-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828394PMC
May 2019
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Half the Genetic Variance in Vitamin D Concentration is Shared with Skin Colour and Sun Exposure Genes.

Behav Genet 2019 07 15;49(4):386-398. Epub 2019 Mar 15.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia.

This study assessed the heritability of 25 hydroxyvitamin D (25(OH)D3) in a large twin cohort and the shared effect of sun exposure and skin colour on 25(OH)D3 variance. Study participants included 1604 twin pairs and their siblings (n = 4020). Twin correlations for 25(OH)D3 concentration were r=0. Read More

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http://dx.doi.org/10.1007/s10519-019-09954-xDOI Listing
July 2019
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The Genetic and Environmental Etiology of Shyness Through Childhood.

Behav Genet 2019 07 15;49(4):376-385. Epub 2019 Mar 15.

School of Psychology, Université Laval, Québec City, QC, G1V 0A6, Canada.

The objective of this study was to examine the genetic and environmental contributions to shyness throughout the school-age period. Participants were 553 twin pairs from the ongoing prospective longitudinal Quebec Newborn Twin Study. Teacher-rated measures of shyness were collected at five time-points from age 6-12 years. Read More

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http://link.springer.com/10.1007/s10519-019-09955-w
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http://dx.doi.org/10.1007/s10519-019-09955-wDOI Listing
July 2019
2 Reads

Genetics and Human Agency: The Philosophy of Behavior Genetics Introduction to the Special Issue.

Authors:
Eric Turkheimer

Behav Genet 2019 03;49(2):123-127

University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1007/s10519-019-09952-zDOI Listing
March 2019
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Sibling Similarity in Metabolic Syndrome: The Portuguese Sibling Study on Growth, Fitness, Lifestyle and Health.

Behav Genet 2019 05 27;49(3):299-309. Epub 2019 Feb 27.

CIFI2D, Faculty of Sport, University of Porto, 4099-002, Porto, Portugal.

This study aims to estimate sibling resemblance in metabolic syndrome (MS) markers, and to investigate the associations of biological and behavioral characteristics with MS. The sample comprises 679 biological siblings (363 females; 316 males) aged 9-20 years. MS markers included waist circumference (WC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TRI), fasting glucose (GLU) and systolic blood pressure (SBP). Read More

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http://link.springer.com/10.1007/s10519-019-09953-y
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http://dx.doi.org/10.1007/s10519-019-09953-yDOI Listing
May 2019
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A Genetic Investigation of the Well-Being Spectrum.

Behav Genet 2019 05 27;49(3):286-297. Epub 2019 Feb 27.

Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.

The interrelations among well-being, neuroticism, and depression can be captured in a so-called well-being spectrum (3-phenotype well-being spectrum, 3-WBS). Several other human traits are likely linked to the 3-WBS. In the present study, we investigate how the 3-WBS can be expanded. Read More

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http://dx.doi.org/10.1007/s10519-019-09951-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497622PMC
May 2019
3 Reads