2,259,161 results match your criteria Behavior Genetics [Journal]


Validation of the Rotterdam Elderly Pain Observation Scale (REPOS) in the hospital setting.

Pain Pract 2018 Dec 16. Epub 2018 Dec 16.

Intensive Care and Department of Pediatric surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

Background: The Rotterdam Elderly Pain Observation Scale (REPOS) has been proven useful to assess pain in non-communicative and cognitively impaired nursing home residents. We evaluated whether the REPOS is also reliable and valid for pain assessment in the hospital setting.

Methods: In this prospective multicenter observational study, surgical patients were observed perioperatively at bedside and internal medicine patients were filmed during a possible painful moment and in rest. Read More

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December 2018

Soil organic carbon stability in forests: distinct effects of tree species identity and traits.

Glob Chang Biol 2018 Dec 16. Epub 2018 Dec 16.

Chair of Soil Science, Technical University Munich (TUM), Emil-Ramann-Str. 2, D-85354, Freising, Germany.

Rising atmospheric CO concentrations have increased interest in the potential for forest ecosystems and soils to act as carbon (C) sinks. While soil organic C contents often vary with tree species identity, little is known about if, and how, tree species influence the stability of C in soil. Using a 40-year-old common garden experiment with replicated plots of eleven temperate tree species, we investigated relationships between soil organic matter (SOM) stability in mineral soils and 17 ecological factors (including tree tissue chemistry, magnitude of organic matter inputs and their turnover, microbial community descriptors, and soil physico-chemical properties). Read More

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December 2018

Deficits in Inhibitory Control May Place Service Members at Risk for Posttraumatic Stress Disorder and Negative Parenting Behavior Following Deployment-Related Trauma.

J Trauma Stress 2018 Dec;31(6):866-875

Institute of Child Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.

This study examined the mediating role of posttraumatic stress disorder (PTSD) symptoms in the association between deployment-related trauma exposure and parenting behaviors in reserve-component military service members and whether this association was contingent upon parent inhibitory control (IC). Participants were 181 postdeployed fathers and their children. Fathers completed a neurospychological test of IC and self-report measures of trauma exposure and PTSD symptoms. Read More

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December 2018

A Multi-Model Framework to Estimate Perfusion Parameters Using Contrast-Enhanced Ultrasound Imaging.

Med Phys 2018 Dec 16. Epub 2018 Dec 16.

Department of Radiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Purpose: Contrast-enhanced ultrasound imaging (CEUS) has expanded the diagnostic potential of ultrasound by enabling real-time imaging and quantification of tissue perfusion. Several perfusion models and curve fitting methods have been developed to quantify the temporal behavior of tracer signal and standardize perfusion quantification. While the least-squares approach has traditionally been applied for curve-fitting, it can be inadequate for noisy and complex data. Read More

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December 2018

Fucoxanthin prevents lipopolysaccharide-induced depressive-like behavior in mice via AMPK- NF-κB pathway.

Metab Brain Dis 2018 Dec 15. Epub 2018 Dec 15.

Department of Pharmacy, Institute of toxicology and pharmacology, Zhejiang Pharmaceutical College, Ningbo, 315000, China.

Fucoxanthin (FX), a natural carotenoid abundant in edible brown seaweeds, has been shown the great anti-oxidant, anti-inflammatory and anti-diabetic effects in vivo and in vitro. The present study was designed to investigate the effects of FX on lipopolysaccharide (LPS)-induced behavioral defects in mice. In depressive behavior tests, the increased immobility time of forced swimming test and tail suspension test by LPS treatment in mice, which were significantly reversed by FX treatment (200 mg/kg, i. Read More

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December 2018

Crossed obsessive-compulsive personality disorder and impaired theory of mind in temporal lobe epilepsy.

Neurol Sci 2018 Dec 15. Epub 2018 Dec 15.

Department of Diagnostics and Applied Technology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy.

People with epilepsy often suffer psychiatric symptoms or exhibit maladaptive personality characteristics which can impact them more than seizures. This case illustrates a selective association of a Theory of Mind dysfunction, including an impaired comparison of reality and others' behavior, with an obsessive-compulsive personality disorder in a patient with left temporal lobe epilepsy and crossed cognitive functions. The patient revealed visual memory deficits and impaired interpretation of other people's behavior, mental rigidity, and a tendency to formulate inflexible judgements. Read More

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December 2018

Autism in India: a case-control study to understand the association between socio-economic and environmental risk factors.

Acta Neurol Belg 2018 Dec 15. Epub 2018 Dec 15.

Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, 641 046, India.

Autism spectrum disorder is a neurodevelopmental disorder and the cause of autism is still unclear. The aim of this study was to investigate the association of socioeconomic, environmental, pregnancy and newborn-related risk factors among children with autism spectrum disorders. This was a population-based case-control study. Read More

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December 2018

The Role of Adaptive Behavior and Parent Expectations in Predicting Post-School Outcomes for Young Adults with Intellectual Disability.

J Autism Dev Disord 2018 Dec 15. Epub 2018 Dec 15.

Nisonger Center, The Ohio State University, 1581 Dodd Drive, McCampbell Hall 357, Columbus, OH, 43210, USA.

This study examined the role of parent expectations and adaptive behavior in predicting outcomes for youth with intellectual disability. A sample of students with intellectual disability were drawn from the National Longitudinal Transition Study-2 for inclusion in this study. Four latent variables were created: demographic factors, adaptive behavior, parent expectations, and post-school outcomes. Read More

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December 2018

Dietary Patterns and Anthropometric Measures of Indian Children with Autism Spectrum Disorder.

J Autism Dev Disord 2018 Dec 15. Epub 2018 Dec 15.

Department of Studies in Food Science and Nutrition, University of Mysore, Mysuru, India.

Research literature on dietary patterns & eating habits of children with Autism Spectrum Disorder (ASD) in India is limited. To explore this, a pilot study (n = 53) which included 45 boys and 8 girls (age group of 2-13 years) was conducted. Three day food records, Food Frequency Questionnaire and Children Eating Behavior Inventory were used to assess the dietary intakes and mealtime behavior problems respectively. Read More

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December 2018

Effect of model race and viewing perspective on body attractiveness and body size assessment in young Caucasian women: an eye-tracking study.

Psychol Res 2018 Dec 15. Epub 2018 Dec 15.

School of Psychology, University of Lincoln, Brayford Pool, Lincoln, LN6 7TS, UK.

Research has indicated that Caucasian women gaze more often at waist-hip and chest regions than other local body areas when assessing female body attractiveness and body size, and this stereotypical gaze distribution is further modulated by their own body satisfaction and body composition. However, little is known whether the model race and viewing perspective could affect women's body-viewing gaze behaviour and body perception. Here, we presented female body images of Caucasian, Asian and African avatars in a continuum of common dress sizes in full frontal, mid-profile and rear view, and asked young Caucasian women to rate the perceived body attractiveness and body size. Read More

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December 2018

Family functioning, moods, and binge eating among urban adolescents.

J Behav Med 2018 Dec 15. Epub 2018 Dec 15.

School of Community and Global Health, Claremont Graduate University, 675 W. Foothill Blvd., Ste. 310, Claremont, CA, 91711, USA.

This study builds upon prior research on associations between moods, family functioning, and binge eating, using ecological momentary assessment to examine moderating effects of family functioning on associations between moods and binge eating. This study was conducted among a nonclinical sample of urban adolescents. Family functioning was assessed using five constructs adopted from the FACES-IV measure: 'family cohesion,' 'family flexibility' 'family communication,' 'family satisfaction,' and 'family balance. Read More

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December 2018

Relative expression of stress-related genes during acclimation at low temperature of psychrotrophic Oenococcus oeni strains from Patagonian wine.

World J Microbiol Biotechnol 2018 Dec 15;35(1). Epub 2018 Dec 15.

Laboratorio de Microbiología Molecular, Instituto de Microbiología Básica y Aplicada (IMBA), Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Sáenz Peña Nº 352, (B1876BXD), Bernal, Buenos Aires, Argentina.

In the present study, we evaluated the transcriptional response of four stress-related genes in three Oenococcus oeni strains after acclimation at two different temperatures. Gene expression was analyzed at time zero and after 48 h acclimation at 18 and 21 °C. After the acclimation period cells were inoculated into sterile Pinot noir wine and MLF was followed for 25 days to investigate if different acclimation temperatures could influence cell survival and MLF performance. Read More

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December 2018

Late systemic symptoms in head and neck cancer survivors.

Support Care Cancer 2018 Dec 15. Epub 2018 Dec 15.

Department of Medicine, Division of Hematology/Oncology, Vanderbilt University Medical Center, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN, 37232, USA.

Purpose: Neuroinflammation and central sensitization from cancer and its therapy may result in chronic systemic symptoms (CSS) such as fatigue, sleep disturbance, chronic widespread pain, mood disorders, neuropsychiatric symptoms, and temperature dysregulation. We undertook a cross-sectional study of CSS in head and neck cancer (HNC) survivors to determine their frequency, severity, and impact.

Methods: HNC patients without evidence of recurrence who were at least 12 months post-treatment completed a one-time battery of self-report measures including the Vanderbilt Head and Neck Symptom survey plus the General Symptom Subscale, the Body Image Quality of Life Inventory, Neurotoxicity Rating Scale, the Profile of Mood States, and a five-item quality of life measure. Read More

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December 2018

"Getting to zero" HIV/AIDS requires effective addressing of HIV issues in LGBT community.

Clin Ter 2018 Nov-Dec;169(6):e269-e271

Department of Microbiology, Panjab University, Chandigarh, India.

This communication is regarding the necessity to address the HIV-related needs of LGBTQIA+ community (Lesbian, Gay, Bisexual, Transgender/transsexual, Queer/Questioning, Intersex, Asexuality, and others) for attaining the 'GETTING TO ZERO' theme for zero new HIV infections, zero AIDS-related deaths and zero discrimination. Most of the times, prevention of HIV/AIDS is talked about in terms of faithfulness to one's partner, use of protective devices such as condoms, pre and post exposure prophylaxis, using anti-retroviral therapies and use of microbicides, behavior change etc. HIV-related issues are however, one of the pertinent issues that needs to be effectively addressed in the LGBTQIA+ community. Read More

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December 2018

Linkage between teen mother's childhood adversity and externalizing behaviors in their children at age 11: Three aspects of parenting.

Child Abuse Negl 2018 Dec 13;88:326-336. Epub 2018 Dec 13.

University of Southern California, Suzanne Dworak-Peck School of Social Work, Department of Children, Youth, and Families, Los Angeles, CA, 669 W. 34th Street, 90089, United States.

Background: Experiences of childhood adversity are consistently associated with compromised behavioral health later in life. Less clear is the intergenerational influence of maternal childhood adversity on developmental outcome in children. Completely unknown are the mechanisms linking teen mother's childhood adversity to child developmental outcomes. Read More

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December 2018

Quantitatively mining and distinguishing situational discomfort grading patterns of drivers from car-following data.

Authors:
Geqi Qi Wei Guan

Accid Anal Prev 2018 Dec 13;123:282-290. Epub 2018 Dec 13.

MOE Key Laboratory of Urban, Transportation Complex System Theory and Technology, Beijing Jiaotong University, Beijing 100044, PR China. Electronic address:

Situational discomfort awareness plays an important role in decision making among drivers and has rarely been discussed in detail in previous research. An instrumented vehicle was used to collect car-following data from multiple drivers, thereby quantitatively examining situational discomfort grading patterns using a new discomfort grading method and the latent Dirichlet allocation model. In this process, the gas pedal data and speed difference data are particularly involved in the computation for providing broader meaning to discomfort and building more comprehensive situations. Read More

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December 2018

A hierarchical machine learning classification approach for secondary task identification from observed driving behavior data.

Accid Anal Prev 2018 Dec 13;123:274-281. Epub 2018 Dec 13.

Department of Civil and Environmental Engineering, University of Alabama, Huntsville, AL 35899, United States. Electronic address:

According to NHTSA, more than 3477 people (including 551 non-occupants) were killed and 391,000 were injured due to distraction-related crashes in 2015. The distracted driving epidemic has long been under research to identify its impact on driving behavior. There have been a few attempts to detect drivers' engagement in secondary tasks from observed driving behavior. Read More

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December 2018

Evaluation of pedestrian crossing behavior and safety at uncontrolled mid-block crosswalks with different numbers of lanes in China.

Accid Anal Prev 2018 Dec 13;123:263-273. Epub 2018 Dec 13.

Wuhan University of Technology, China.

This study aims to investigate pedestrian crossing behavior and safety at uncontrolled mid-block crosswalks with different numbers of vehicle lanes. For this purpose, twelve uncontrolled mid-block crosswalks in Wuhan, China were selected to collect data via field investigation. Descriptive statistics were used to analyze pedestrian crossing behavior, and the distribution of pedestrian-vehicle conflicts on different vehicle lanes was given. Read More

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December 2018

Fibril bending stiffness of 3D collagen matrices instructs spreading and clustering of invasive and non-invasive breast cancer cells.

Biomaterials 2018 Dec 10;193:47-57. Epub 2018 Dec 10.

Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, 04103, Germany. Electronic address:

Extracellular matrix stiffening of breast tissues has been clinically correlated with malignant transformation and poor prognosis. An increase of collagen fibril diameter and lysyl-oxidase mediated crosslinking has been observed in advanced tumor stages. Many current reports suggest that the local mechanical properties of single fibrillar components dominantly regulate cancer cell behavior. Read More

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December 2018

Association between prenatal opioid exposure, neonatal opioid withdrawal syndrome, and neurodevelopmental and behavioral outcomes at 5-8 months of age.

Early Hum Dev 2018 Dec 13;128:69-76. Epub 2018 Dec 13.

Department of Family and Community Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, United States of America.

Background: While use of prescription opioids and medication assisted therapy (MAT) for opioid use disorder in pregnancy, as well as the incidence of neonatal opioid withdrawal syndrome (NOWS) continue to rise, little is known about outcomes for children with NOWS beyond the newborn period.

Methods: We examined 1) prenatal MAT exposure vs. unexposed healthy controls [HC]; and 2) treatment for NOWS and NOWS severity on infant neurodevelopmental and behavioral outcomes at 5-8 months of age in 78 maternal-infant pairs from the ENRICH prospective cohort study. Read More

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December 2018

Electrochemical behavior of titanium and platinum in dicarboxilic amino acids solution.

Bioelectrochemistry 2018 Dec 4;126:113-120. Epub 2018 Dec 4.

Irkutsk State University, 1, K.Marx Str., Irkutsk 664003, Russia. Electronic address:

Titanium and platinum samples as components of bimetallic implants for the osteoregeneration process have been modified in solutions modeling biological systems and studied by means of cyclic voltammetry, electrochemical impedance spectroscopy and scanning probe microscopy. While aspartic and glutamic acids did not adsorb significantly on platinum in the potential region investigated, the presence of the amino acids affects oxide layer growth on the titanium surface under anodic polarization. The two studied amino acids behave differently on the titanium electrode surface due to differences in adsorption modes of these substances. Read More

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December 2018

Self-assembling and biological properties of single-chain dicationic pyridinium-based surfactants.

Colloids Surf B Biointerfaces 2018 Dec 6;175:351-357. Epub 2018 Dec 6.

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., Kazan, 420088, Russia; Kazan National Research Technological University, 68 K. Marks str., Kazan, 420015, Russia.

In this work, the dicationic surfactants containing viologen and vinylbipyridinium moieties and hexadecyl chains were synthesized, and their aggregation behavior in water solutions was investigated by surface tension, conductivity measurements, hydrophobic probe solubilization, dynamic light scattering and electrophoretic measurements. Effect of UV-light on cis-trans isomerism of vinylbipyridinium derivative was determined. Antimicrobial activity and the influence of these surfactants on cell viability depended on the concentration and type of surfactant used. Read More

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December 2018

Novel breviscapine nanocrystals modified by panax notoginseng saponins for enhancing bioavailability and synergistic anti-platelet aggregation effect.

Colloids Surf B Biointerfaces 2018 Nov 27;175:333-342. Epub 2018 Nov 27.

Jiangxi University of Traditional Chinese Medicine, 1688 Meilingdadao Road, Nanchang 330004, China.

Breviscapine (BVP) is a flavonoid compound with strong neuroprotective and anti-platelet aggregation effect. The objective of this study is to design novel BVP nanocrystals modified by natural panax notoginseng saponins (PNS) for enhancing dissolution and anti-platelet aggregation effect of BVP. BVP nanocrystals modified by PNS (BVP-NC/PNS) were firstly prepared by coupling homogenization technology and freeze-drying technology, and BVP nanocrystals modified by RH40 (BVP-NC/RH40) as reference for comparison. Read More

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November 2018

Structure and stability of nanofluid films wetting solids: An overview.

Adv Colloid Interface Sci 2018 Dec 7;264:1-10. Epub 2018 Dec 7.

Department of Chemical Engineering, Illinois Institute of Technology, Chicago, IL, 60616, United States.

When an air bubble or an oil droplet in a nanofluid (liquid containing dispersed nanoparticles) approaches a solid surface, a nanofluid film is formed between the bubble or drop and a solid substrate. The nanoparticles confined in the film surfaces tend to self-layer and the film thins in a stepwise manner. The wetting behavior and film stability criteria valid for the classical molecularly thin films cannot be applied to nanofilm. Read More

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December 2018

Non-motor predictors of freezing of gait in Parkinson's disease.

Gait Posture 2018 Dec 6;68:311-316. Epub 2018 Dec 6.

Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, USA; Department of Neurology and Neurological Sciences, Stanford University, USA. Electronic address:

Background: The etiology of freezing of gait in Parkinson's disease (PD) is yet to be clarified. Non-motor risk factors including cognitive impairment, sleep disturbance and mood disorders have been shown in freezing of gait.

Research Question: We aimed to determine the predictive value of non-motor features in freezing of gait development. Read More

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December 2018

Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway.

Free Radic Biol Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

Traumatic brain injury (TBI) is a principal cause of death and disability worldwide. Melatonin, a hormone made by the pineal gland, is known to have anti-inflammatory and antioxidant properties. In this study, using a weight-drop model of TBI, we investigated the protective effects of ramelteon, a melatonin MT1/MT2 receptor agonist, and its underlying mechanisms of action. Read More

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December 2018

How changes in molecular weight and PDI of a polymer in amorphous solid dispersions impact dissolution performance.

Int J Pharm 2018 Dec 13. Epub 2018 Dec 13.

Institute of Pharmacy, Faculty I of Natural Sciences, Martin Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle/Saale, Germany. Electronic address:

Polymers functionally contribute to supersaturation and precipitation inhibition of the active pharmaceutical ingredient (API) in amorphous solid dispersions (ASD). Therefore, it is necessary to monitor physicochemical changes of the polymeric carrier caused by the manufacturing process. This is especially important when the material is exposed to heat and shear stress as in case of hot-melt extrusion (HME). Read More

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December 2018

Effects of parity and litter size on cortisol measures in commercially housed sows and their offspring.

Physiol Behav 2018 Dec 13. Epub 2018 Dec 13.

Behavior & Welfare Group, Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; Brain Center Rudolf Magnus, Utrecht University, Utrecht, The Netherlands.

Breeding sows are regularly exposed to on-farm stressors throughout the duration of their production period. The impact of such stressors may differ for primi- and multiparous sows, as sows could learn to cope with stressors as they gain experience with them. If parity affects stress in sows, it may also impact their prenatal offspring through differential maternal stress. Read More

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December 2018

A dual-process psychobiological model of temperament predicts liking and wanting for food and trait disinhibition.

Appetite 2018 Dec 13. Epub 2018 Dec 13.

Queensland University of Technology (QUT), Kelvin Grove Campus, School of Exercise and Nutrition Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Victoria Park Rd, Kelvin Grove, QLD, 4059, Australia. Electronic address:

A dual-process model of temperament, incorporating the Behavioural Inhibition System (BIS), Behavioural Activation System (BAS) and effortful control (EC), may help to predict hedonic responses to palatable food and trait disinhibition.

Purpose: This study aimed to determine if the BIS, BAS and EC predicted liking and wanting for high-fat, sweet foods in adults with overweight and obesity, and if collectively, these variables predicted the eating behaviour trait of Disinhibition.

Methods: 168 adults (104 females, mean BMI = 33. Read More

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December 2018

Imprinted genes influencing the quality of maternal care.

Front Neuroendocrinol 2018 Dec 13. Epub 2018 Dec 13.

Biomedicine Division, School of Biosciences, Cardiff University, Cardiff, UK, CF10 3AX, UK. Electronic address:

In mammals successful rearing imposes a cost on later reproductive fitness specifically on the mother creating the potential for parental conflict. Loss of function of three imprinted genes in the dam result in deficits in maternal care suggesting that, like maternal nutrients, maternal care is a resource over which the parental genomes are in conflict. However, the induction of maternal care is a complex and highly regulated process. Read More

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December 2018

Out of control? Acting out anger is associated with deficient prefrontal emotional action control in male patients with borderline personality disorder.

Neuropharmacology 2018 Dec 13. Epub 2018 Dec 13.

Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Difficulty in anger control and anger-related aggressive outbursts against others are frequently reported by patients with borderline personality disorder (BPD). Although male sex is a known predictor for aggression, hardly any study has addressed the neural correlates of deficient anger control in male patients with BPD. Building on previous reports in female BPD, we investigated the involvement of lateral antero- and dorsal prefrontal cortex in the control of fast emotional actions and its relation to self-reported tendencies to act out anger. Read More

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December 2018

Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats.

Neuropharmacology 2018 Dec 13. Epub 2018 Dec 13.

Pharmacology and Therapeutics, NCBES Galway Neuroscience Centre, National University of Ireland, Galway, Ireland. Electronic address:

Modulation of the opioid system has re-emerged as a potential therapeutic avenue for treating depression, with efficacy of a fixed-dose combination of buprenorphine (BUP), a partial μ-opioid receptor (MOR) agonist and κ-opioid receptor (KOR) antagonist, and samidorphan (SAM), a potent MOR antagonist, as an adjuvant treatment in patients with major depressive disorder (MDD). To advance understanding of the mechanism of action underlying this combination, we examined BUP, SAM and their combination in a series of rat behavioural assays. We examined effects on locomotor activity in Sprague Dawley (SD) rats over an extended period of time in a home-cage tracking system, and behavioural despair (immobility) in the forced swim test (FST), a commonly-used test to study antidepressants, in SD and Wistar-Kyoto (WKY) rats. Read More

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December 2018

Potential and constraints for the application of CFD combined with Lagrangian particle tracking to dry powder inhalers.

Eur J Pharm Sci 2018 Dec 13. Epub 2018 Dec 13.

Multiphase Flow Systems (MPS), Institute of Process Engineering, Otto-von-Guericke-University (OvGU) Magdeburg, Zeppelinstraße 1, D-06130 Halle (Saale), Germany.

For about 15 years the performance of dry powder inhalers (DPIs) has been numerically analysed through CFD (computational fluid dynamics) approaches with the objective of understanding the evolving flow structures and the resulting transport of drug particles. Naturally the main interest is the numerical prediction of the emitted fine particle fraction (FPF) which is able to penetrate the lung airways. Due to the mostly used drug formulations (i. Read More

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December 2018

The sex-specific effects of LPS on depressive-like behavior and oxidative stress in the hippocampus of the mouse.

Neuroscience 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychiatry, Penn State College of Medicine and Penn State Milton S. Hershey Medical Center, Hershey, PA, 17033, United States.

Many human and animal studies have implicated inflammation as a mediator of oxidative stress and a possible contributor to hippocampal atrophy in the pathophysiology of major depressive disorder. We aimed to examine the effect of peripheral, systemic inflammation on oxidative stress and apoptosis in the hippocampi of male and female mice. We hypothesized that (1) lipopolysaccharide (LPS) would induce depressive-like behavior and hippocampal oxidative stress after 1 day in males, and (2) that a single LPS exposure would result in hippocampal apoptosis at 28 days. Read More

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December 2018

Synthesis and characterization of a photoresponsive doxorubicin/combretastatin A4 hybrid prodrug.

Bioorg Med Chem Lett 2018 Dec 10. Epub 2018 Dec 10.

Laboratory of Antiinfectives, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, PR China. Electronic address:

To explore the application of photoremovable protecting groups (PPGs) in the field of combination chemotherapy, we designed and synthesized a photoresponsive hybrid prodrug 4 that bearing both doxorubicin (DOX) and combretastatin A4 (CA4). Light triggered drug release investigation found that DOX release was mainly accomplished by 405 nm light while CA4 release was mainly triggered by 365 nm light, i.e. Read More

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December 2018

A Cluster-Randomized Trial on Small Incentives to Promote Physical Activity.

Am J Prev Med 2018 Dec 13. Epub 2018 Dec 13.

Center for Digital Health Interventions, Institute of Technology Management, University of St. Gallen, St. Gallen, Switzerland. Electronic address:

Introduction: There has been limited research investigating whether small financial incentives can promote participation, behavior change, and engagement in physical activity promotion programs. This study evaluates the effects of two types of small financial incentives within a physical activity promotion program of a Swiss health insurance company.

Study Design: Three-arm cluster-randomized trial comparing small personal financial incentives and charity financial incentives (10 Swiss Francs, equal to US$10. Read More

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December 2018

Smoking during pregnancy, stigma and secrets: Visual methods exploration in the UK.

Women Birth 2018 Dec 12. Epub 2018 Dec 12.

School of Social Sciences, Cardiff University,Glamorgan Building, King Edward VII Avenue, Cardiff, CF10 3WT, United Kingdom. Electronic address:

Background: Moral judgements are commonly directed towards mothers through reference to health behaviour in pregnancy, and working-class mothers are particularly subject to this moral gaze.

Aim: To gain an in-depth understanding of the health issues affecting 10 low income pregnant women from deprived areas of south Wales, UK.

Methods: Participants completed visual activities (timelines, collaging or thought bubbles and dyad sandboxing) prior to each interview. Read More

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December 2018

Rehabilitation of social cognition impairment after traumatic brain injury: A systematic review.

Neurologia 2018 Dec 12. Epub 2018 Dec 12.

Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, España; Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Barcelona, España; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, España.

Introduction: Many studies have described the presence of difficulty processing and generating social behaviour in patients who have suffered a traumatic brain injury (TBI). These difficulties in social cognition (SC) deteriorate personal relationships in the family, at work, or in the community. However, therapeutic programmes aiming to improve SC continue to be an outstanding issue in clinical practice. Read More

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December 2018

Towards viscoelastic characterisation of the human ulnar nerve: An early assessment using embalmed cadavers.

Med Eng Phys 2018 Dec 13. Epub 2018 Dec 13.

Department of Anatomy, College of Medical and Dental Sciences, University of Birmingham, United Kingdom. Electronic address:

Cubital tunnel syndrome is the most prevalent neuropathy of the ulnar nerve and its aetiology is controversial. Potential replacement materials should display similar viscoelastic properties. The purpose of this study was to assess the feasibility and merit of quantifying the frequency-dependent viscoelastic properties of proximal and distal sections of the human ulnar nerve. Read More

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December 2018

Investigation and prediction of retention characteristics of imidazoline and serotonin receptor ligands and their related compounds on mixed-mode stationary phase.

J Chromatogr A 2018 Nov 23. Epub 2018 Nov 23.

Department of Pharmaceutical Chemistry, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, Belgrade 11000, Serbia.

Investigation of the retention behavior of a wide range of analytes, 43 nitrogen containing heterocyclic and guanidine derivatives such, as imidazoline and serotonin receptor ligands or their related compounds, was performed on mixed-mode stationary phase in the combined reversed-phase (RP) and hydrophilic interaction liquid chromatography (HILIC) modes. Suitability of the linear retention modelling in the HILIC and RP modes was tested including separate contributions from adsorption and partition. For the HILIC retention, the partition model was found to provide better description compared with the adsorption model. Read More

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November 2018

Insect toxins - selective pharmacological tools and drug/chemical leads.

Curr Opin Insect Sci 2018 Dec 9;30:93-98. Epub 2018 Oct 9.

Centre for Respiratory Biology, UCL Respiratory, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK. Electronic address:

Insect toxins comprise a diverse array of chemicals ranging from small molecules, polyamines and peptide toxins. Many target nervous system and neuromuscular ion channels and so rapidly affect the behaviour of animals to which the toxin is applied or injected. Other modes of action have also been identified. Read More

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December 2018

Loss of ATM positively regulates Rac1 activity and cellular migration through oxidative stress.

Biochem Biophys Res Commun 2018 Dec 13. Epub 2018 Dec 13.

Department of Chemistry, High Point University, High Point, NC, 27268, USA. Electronic address:

Ataxia-telangiectasia mutated (ATM) is a serine-threonine kinase that is integral in the response to DNA double-stranded breaks (DSBs). Cells and tissues lacking ATM are prone to tumor development and enhanced tumor cell migration and invasion. Interestingly, ATM-deficient cells exhibit high levels of oxidative stress; however, the direct mechanism whereby ATM-associated oxidative stress may contribute to the cancer phenotype remains largely unexplored. Read More

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December 2018

The determinants of motorcyclists helmet use: Urban arterial road in Khon Kaen City, Thailand.

J Safety Res 2018 Dec 28;67:93-97. Epub 2018 Sep 28.

Faculty of Engineering, Khon Kaen University, Khon Kaen, 40002, Thailand. Electronic address:

Introduction: Currently, Thailand incurs the highest death toll of motorcyclists in the world. The aim of this study was to explore the factors influencing helmet use of motorcyclists in Khon Kaen City, Thailand by using the Logistic regression analysis.

Method: The samples, consisting of 27,977 riders and 6,947 riding passengers, were collected by CCTV installed at several signalized intersections along urban arterial roads. Read More

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December 2018

Association rule analysis of factors contributing to extraordinarily severe traffic crashes in China.

J Safety Res 2018 Dec 5;67:65-75. Epub 2018 Oct 5.

Jiangsu Key Laboratory of Urban ITS, Southeast University, Si Pai Lou #2, Nanjing 210096, China; Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies, Southeast University, Si Pai Lou #2, Nanjing 210096, China; School of Transportation, Southeast University, Si Pai Lou #2, Nanjing 210096, China. Electronic address:

Introduction: This study aimed to investigate the contributing factors to serious casualty traffic crashes and their interdependency in China. Serious casualty crashes are defined as crashes that lead to more than 10 deaths.

Method: The data of serious casualty crashes between 2009 and 2013 were obtained from the Annual Report for Road Traffic Accidents published by the Ministry of Public Security of China (MPSC). Read More

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December 2018

Enhancing safety competencies of young adults: A randomized field trial (RCT).

J Safety Res 2018 Dec 28;67:45-56. Epub 2018 Sep 28.

Finnish Institute of Occupational Health, P.O. Box 40, FI-00032 Helsinki, Finland. Electronic address:

Introduction: Young workers are exposed to various occupational hazards, often with limited experience and skills. In this study, we investigated the effects of the Attitude to Work Program on the safety competencies of young workers. Based on the social cognitive theory, the intervention was developed to help young people adopt an active role in preventing occupational hazards and overcoming barriers to safe work. Read More

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December 2018

Developing safety archetypes of construction industry at project level using system dynamics.

J Safety Res 2018 Dec 27;67:17-26. Epub 2018 Sep 27.

Non-communicable Diseases Research Center, Department of Occupational Health and Safety Engineering, Alborz University of Medical Sciences, Karaj, Iran.

Introduction: Safe behavior and work conditions are a major concern in construction projects. However, accidents occur due to system failures, not a single factor such as unsafe behavior or condition. Construction safety should be investigated by a systematic view capable of illustrating the complex nature of accidents. Read More

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December 2018

Using CyclePhilly data to assess wrong-way riding of cyclists in Philadelphia.

J Safety Res 2018 Dec 13;67:145-153. Epub 2018 Nov 13.

University of Tennessee, 311N John D. Tickle Building, 851 Neyland Drive, Knoxville, TN 37996-2313, USA. Electronic address:

Problem: The increasing use of smartphones and low cost GPS have provided new sources for collecting data and using them to explain travel behavior. This study aims to use data collected from a smartphone application (CyclePhilly) to explain wrong-way riding behavior of cyclists on one-way segments to help better identify the demographic and network factors influencing the wrong-way riding decision making.

Methods: The data used in this study consist of two different sources: (a) Route trips data downloaded from the CyclePhilly Website contained trips detailed up to segment level, collected from May 2014 to April 2016 (12,202 trips by 300 unique users); and (b) Open Street Maps (OSM). Read More

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December 2018

Higher-order cycling skills among 11- to 13-year-old cyclists and relationships with cycling experience, risky behavior, crashes and self-assessed skill.

J Safety Res 2018 Dec 19;67:137-143. Epub 2018 Oct 19.

CROW, Hora plantsoon 18, 6717 LT, Ede, the Netherlands. Electronic address:

Introduction: In the Netherlands, young cyclists are extremely vulnerable in traffic, which may partly be due to their still underdeveloped higher-order cycling skill. So far, knowledge on their actual level of skill is lacking. Using a computerized test battery mimicking real-life risky traffic conditions, this study assessed the level of higher-order cycling skill in children 11 and 12 years of age and tested the hypothesis that these skills show caveats. Read More

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December 2018

Gender differences in children's pedestrian behaviors: Developmental effects.

J Safety Res 2018 Dec 20;67:127-133. Epub 2018 Sep 20.

Department of Psychology, Institute of Nautical Medicine, Nantong University, 9 Seyuan Road, Nantong 226019, China.

Introduction: All child pedestrians are vulnerable to road traffic injuries, but there is evidence that boys may be at greater risk than girls, at least among some age groups.

Method: To create effective intervention programs, research on how boys and girls of particular ages behave as pedestrians, and whether there are gender differences that increase risk for particular genders at particular ages, is needed. In this study, 255 boys and 235 girls in grade 1 through 6 from two primary schools in Nantong city, China, were unobtrusively videotaped when walking to school in the morning. Read More

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December 2018

Dual-emitting film with cellulose nanocrystal-assisted carbon dots grafted SrAlO, Eu, Dy phosphors for temperature sensing.

Carbohydr Polym 2019 Feb 16;206:767-777. Epub 2018 Nov 16.

Center for Renewable Carbon, University of Tennessee, Knoxville, TN, 37996, USA. Electronic address:

In this study, we synthesized a novel dual-emitting fluorescent phosphor from cellulose nanocrystal (CNC)-assisted carbon dots (CDs)-grafted SrAlO, Eu, Dy (SAO) through a facile core-shell process. The CNC-CDs-coated SAO presents excellent scattered dual-emission and improved water resistance without destruction of the SrAlO crystals. The phosphors were then reacted with coupling amino-silane and assembled with nanofibrillated cellulose skeletons to create flexible isotropic films. Read More

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February 2019
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