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    2427 results match your criteria Behavior Genetics [Journal]

    1 OF 49

    Sociability in Fruit Flies: Genetic Variation, Heritability and Plasticity.
    Behav Genet 2018 May 23;48(3):247-258. Epub 2018 Apr 23.
    Animal Behaviour Group, Department of Psychology, Neuroscience & Behaviour, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
    Sociability, defined as individuals' propensity to participate in non-aggressive activities with conspecifics, is a fundamental feature of behavior in many animals including humans. However, we still have a limited knowledge of the mechanisms and evolutionary biology of sociability. To enhance our understanding, we developed a new protocol to quantify sociability in fruit flies (Drosophila melanogaster). Read More

    Etiology of Stability and Growth of Internalizing and Externalizing Behavior Problems Across Childhood and Adolescence.
    Behav Genet 2018 Apr 20. Epub 2018 Apr 20.
    Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
    Internalizing and externalizing behaviors are heritable, and show genetic stability during childhood and adolescence. Less work has explored how genes influence individual differences in developmental trajectories. We estimated ACE biometrical latent growth curve models for the Teacher Report Form (TRF) and parent Child Behavior Checklist (CBCL) internalizing and externalizing scales from ages 7 to 16 years in 408 twin pairs from the Colorado Longitudinal Twin Study. Read More

    Social Support and Strain Across Close Relationships: A Twin Study.
    Behav Genet 2018 May 12;48(3):173-186. Epub 2018 Apr 12.
    Division of Health Data and Digitalization, Center for Fertility and Health and Department of Genetics and Bioinformatics, The Norwegian Institute of Public Health, PO Box 4404, 0403, Oslo, Norway.
    Social relationships play a critical role in health and well-being throughout life. We analyzed the genetic and environmental variance co-variance structure for social support and strain across four sets of relationships including with one's co-twin, spouse/partner, family and friends. The sample included 5288 Norwegian twins aged 40-80. Read More

    Facilitatory Effect of IL-6 Deficiency on Long-Term Spatial Memory in Young Adult Mice.
    Behav Genet 2018 May 4;48(3):236-246. Epub 2018 Apr 4.
    Department of General and Experimental Pathology, Medical University of Bialystok, Mickiewicza 2c, 15-222, Bialystok, Poland.
    The significance of interleukin 6 (IL-6) in long-term reference memory was tested in the Morris water maze (MWM) in 4-month-old C57BL/6J IL-6-deficient (IL-6 KO) and control mice. Three-day learning measured by escape latency time to find the hidden platform was comparable in both genotypes. In a single probe trial performed 7 days later, without the platform, latency to the platform site and path length to the target place were significantly shorter (p < 0. Read More

    Genetic and Environmental Influences on Language Ability in Older Adults: Findings from the Older Australian Twins Study.
    Behav Genet 2018 May 4;48(3):187-197. Epub 2018 Apr 4.
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
    We used a sub-sample from the Older Australian Twins Study to estimate the heritability of performance on three tests of language ability: Boston Naming Test (BNT), Letter/Phonemic Fluency (FAS) and Category/Semantic Fluency (CFT) Tests. After adjusting for age, sex, education, mood, and global cognition (GC), heritability estimates obtained for the three tests were 0.35, 0. Read More

    Gender Differences in the Structure of Marital Quality.
    Behav Genet 2018 May 22;48(3):209-223. Epub 2018 Mar 22.
    University of Virginia, Charlottesville, USA.
    Marriages consist of shared experiences and interactions between husbands and wives that may lead to different impressions of the quality of the relationship. Few studies, unfortunately, have tested gender differences in the structure of marital quality, and even fewer studies have evaluated whether genetic and environmental influences on marital quality differ across gender. In this study, we evaluated gender differences in the structure of marital quality using independent samples of married male (n = 2406) and married female (n = 2215) participants from the National Survey of Midlife Development in the United States who provided ratings on twenty-eight marital quality items encompassing six marital quality constructs. Read More

    Weighted Burden Analysis of Exome-Sequenced Case-Control Sample Implicates Synaptic Genes in Schizophrenia Aetiology.
    Behav Genet 2018 May 21;48(3):198-208. Epub 2018 Mar 21.
    UCL Genetics Institute, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK.
    A previous study of exome-sequenced schizophrenia cases and controls reported an excess of singleton, gene-disruptive variants among cases, concentrated in particular gene sets. The dataset included a number of subjects with a substantial Finnish contribution to ancestry. We have reanalysed the same dataset after removal of these subjects and we have also included non-singleton variants of all types using a weighted burden test which assigns higher weights to variants predicted to have a greater effect on protein function. Read More

    Short-Term Genetic Selection for Adolescent Locomotor Sensitivity to Delta9-Tetrahydrocannabinol (THC).
    Behav Genet 2018 May 17;48(3):224-235. Epub 2018 Mar 17.
    Department of Psychology, Indiana University - Purdue University - Indianapolis, 402 N Blackford St, LD 124, Indianapolis, IN, 46202, USA.
    Cannabis use is linked to positive and negative outcomes. Identifying genetic targets of susceptibility to the negative effects of cannabinoid use is of growing importance. The current study sought to complete short-term selective breeding for adolescent sensitivity and resistance to the locomotor effects of a single 10 mg/kg THC dose in the open field. Read More

    A Brief Critique of the TATES Procedure.
    Behav Genet 2018 03 21;48(2):155-167. Epub 2018 Feb 21.
    Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
    The Trait-based test that uses the Extended Simes procedure (TATES) was developed as a method for conducting multivariate GWAS for correlated phenotypes whose underlying genetic architecture is complex. In this paper, we provide a brief methodological critique of the TATES method using simulated examples and a mathematical proof. Our simulated examples using correlated phenotypes show that the Type I error rate is higher than expected, and that more TATES p values fall outside of the confidence interval relative to expectation. Read More

    The Biological Contributions to Gender Identity and Gender Diversity: Bringing Data to the Table.
    Behav Genet 2018 03 19;48(2):95-108. Epub 2018 Feb 19.
    Program for LGBTI Health, Vanderbilt University Medical Center, Nashville, TN, USA.
    The American Psychological Association defines gender identity as, "A person's deeply-felt, inherent sense of being a boy, a man, or a male; a girl, a woman, or a female; or an alternative gender (e.g., genderqueer, gender nonconforming, gender neutral) that may or may not correspond to a person's sex assigned at birth or to a person's primary or secondary sex characteristics" (American Psychological Association, Am Psychol 70(9):832-864, 2015). Read More

    The Speed of Progression to Tobacco and Alcohol Dependence: A Twin Study.
    Behav Genet 2018 03 9;48(2):109-124. Epub 2018 Feb 9.
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA.
    We investigated the etiological role of genetic and environmental influences for two milestones of tobacco and alcohol use: age of initiation, and speed of progression to dependence (latency). Study participants included 1352 monozygotic and 1422 dizygotic twins (mean age at assessment = 24.31). Read More

    Genetic and Environmental Influences on Self-Control: Assessing Self-Control with the ASEBA Self-Control Scale.
    Behav Genet 2018 03 5;48(2):135-146. Epub 2018 Feb 5.
    Department of Biological Psychology, Vrije Universiteit Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
    This study used a theoretically-derived set of items of the Achenbach System of Empirically Based Assessment to develop the Achenbach Self-Control Scale (ASCS) for 7-16 year olds. Using a large dataset of over 20,000 children, who are enrolled in the Netherlands Twin Register, we demonstrated the psychometric properties of the ASCS for parent-, self- and teacher-report by examining internal and criterion validity, and inter-rater and test-retest reliability. We found associations between the ASCS and measures of well-being, educational achievement, and substance use. Read More

    The Association Between Toddlerhood Self-Control and Later Externalizing Problems.
    Behav Genet 2018 03 3;48(2):125-134. Epub 2018 Jan 3.
    The Center for Healthy Minds, University of Wisconsin, 625 W. Washington Ave., Madison, WI, 53703, USA.
    Lower self-control is a significant correlate or predictor of a wide range of adult outcomes, and this association may be due to more general tendencies toward childhood externalizing problems. The present study examined the association between toddlerhood self-control expressed within a "don't" compliance task (at 14-36 months) and later externalizing problems (parent-reported externalizing problems from age 4 to 12 years, teacher-reported externalizing problems from age 7 to 12 years, and self-reported conduct disorder symptoms at age 17 years) in a longitudinal, genetically informative study. The slope of self-control, but not its intercept, predicted later teacher-reported, but not parent- or self-reported, externalizing problems. Read More

    Overlap Between the General Factor of Personality and Trait Emotional Intelligence: A Genetic Correlation Study.
    Behav Genet 2018 03 20;48(2):147-154. Epub 2017 Dec 20.
    London Psychometric Laboratory, University College London, London, UK.
    A previous meta-analysis (Van der Linden et al., Psychol Bull 143:36-52, 2017) showed that the General Factor of Personality (GFP) overlaps with ability as well as trait emotional intelligence (EI). The correlation between trait EI and the GFP was so high (ρ = 0. Read More

    Genetic Variance in Homophobia: Evidence from Self- and Peer Reports.
    Behav Genet 2018 01 21;48(1):34-43. Epub 2017 Nov 21.
    Department of Psychology, MSB Medical School Berlin, Calandrellistr. 1-9, 12247, Berlin, Germany.
    The present twin study combined self- and peer assessments of twins' general homophobia targeting gay men in order to replicate previous behavior genetic findings across different rater perspectives and to disentangle self-rater-specific variance from common variance in self- and peer-reported homophobia (i.e., rater-consistent variance). Read More

    Cross-Lagged Analysis of Interplay Between Differential Traits in Sibling Pairs: Validation and Application to Parenting Behavior and ADHD Symptomatology.
    Behav Genet 2018 01 17;48(1):22-33. Epub 2017 Nov 17.
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
    Understanding the factors that contribute to behavioral traits is a complex task, and partitioning variance into latent genetic and environmental components is a useful beginning, but it should not also be the end. Many constructs are influenced by their contextual milieu, and accounting for background effects (such as gene-environment correlation) is necessary to avoid bias. This study introduces a method for examining the interplay between traits, in a longitudinal design using differential items in sibling pairs. Read More

    Adaptive SNP-Set Association Testing in Generalized Linear Mixed Models with Application to Family Studies.
    Behav Genet 2018 01 17;48(1):55-66. Epub 2017 Nov 17.
    Division of Biostatistics, University of Minnesota, A460 Mayo Building, MMC 303, 420 Delaware St. SE, Minneapolis, MN, 55455, USA.
    In genome-wide association studies (GWAS), it has been increasingly recognized that, as a complementary approach to standard single SNP analyses, it may be beneficial to analyze a group of functionally related SNPs together. Among the existent population-based SNP-set association tests, two adaptive tests, the aSPU test and the aSPUpath test, offer a powerful and general approach at the gene- and pathway-levels by data-adaptively combining the results across multiple SNPs (and genes) such that high statistical power can be maintained across a wide range of scenarios. We extend the aSPU and the aSPUpath test to familial data under the framework of the generalized linear mixed models (GLMMs), which can take account of both subject relatedness and possible population structure. Read More

    The Impact of Variation in Twin Relatedness on Estimates of Heritability and Environmental Influences.
    Behav Genet 2018 01 2;48(1):44-54. Epub 2017 Nov 2.
    Department of Psychology, The Pennsylvania State University, 431 Moore Building, University Park, PA, 16802, USA.
    By taking advantage of the natural variation in genetic relatedness among identical (monozygotic: MZ) and fraternal (dizygotic: DZ) twins, twin studies are able to estimate genetic and environmental contributions to complex human behaviors. Recently concerns have been raised about the accuracy of twin studies in light of findings of genetic and epigenetic changes in twins. One of the concerns raised is that MZ twins are not 100% genetically and epigenetically similar because they show variations in their genomes and epigenomes leading to inaccurate estimates of heritability. Read More

    Partitioning Phenotypic Variance Due to Parent-of-Origin Effects Using Genomic Relatedness Matrices.
    Behav Genet 2018 01 2;48(1):67-79. Epub 2017 Nov 2.
    MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
    We propose a new method, G-REMLadp, to estimate the phenotypic variance explained by parent-of-origin effects (POEs) across the genome. Our method uses restricted maximum likelihood analysis of genome-wide genetic relatedness matrices based on individuals' phased genotypes. Genome-wide SNP data from parent child duos or trios is required to obtain relatedness matrices indexing the parental origin of offspring alleles, as well as offspring phenotype data to partition the trait variation into variance components. Read More

    Persistent One-Way Walking in a Circular Arena in Drosophila melanogaster Canton-S Strain.
    Behav Genet 2018 01 2;48(1):80-93. Epub 2017 Nov 2.
    Department of Biology, Queen's University, Kingston, ON, K7L 3N6, Canada.
    We describe persistent one-way walking of Drosophila melanogaster in a circular arena. Wild-type Canton-S adult flies walked in one direction, counter-clockwise or clockwise, for minutes, whereas white-eyed mutant [Formula: see text] changed directions frequently. Locomotion in the circular arena could be classified into four components: counter-clockwise walking, clockwise walking, nondirectional walking and pausing. Read More

    An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register.
    Behav Genet 2018 01 17;48(1):1-11. Epub 2017 Oct 17.
    Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
    For the participants in the Netherlands Twin Register (NTR) we constructed the extended pedigrees which specify all relations among nuclear and larger twin families in the register. A total of 253,015 subjects from 58,645 families were linked to each other, to the degree that we had information on the relations among participants. We describe the algorithm that was applied to construct the pedigrees. Read More

    Effects of Social Attitude Change on Smoking Heritability.
    Behav Genet 2018 01 25;48(1):12-21. Epub 2017 Sep 25.
    Departament of Human Anatomy and Psychobiology, Universidad de Murcia, Murcia, Spain.
    Societal attitudes and norms to female smoking changed in Spain in the mid-twentieth century from a restrictive to a tolerant, and an even pro-smoking, posture, while social attitudes remained stable for males. We explored whether this difference in gender-related social norms influenced the heritability of two tobacco use measures: lifetime smoking and number of years smoking. We used a population-based sample of 2285 twins (mean age = 55. Read More

    Identification of Candidate Genes for Generalized Tonic-Clonic Seizures in Noda Epileptic Rat.
    Behav Genet 2017 11 21;47(6):609-619. Epub 2017 Sep 21.
    Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
    The Noda epileptic rat (NER) exhibits generalized tonic-clonic seizures (GTCS). A genetic linkage analysis identified two GTCS-associated loci, Ner1 on Chr 1 and Ner3 on Chr 5. The wild-type Ner1 and Ner3 alleles suppressed GTCS when combined in double-locus congenic lines, but not when present in single-locus congenic lines. Read More

    Moderation of Genetic Influences on Alcohol Involvement by Rural Residency among Adolescents: Results from the 1962 National Merit Twin Study.
    Behav Genet 2017 11 18;47(6):587-595. Epub 2017 Sep 18.
    Department of Psychological Sciences, University of Missouri, 210 McAlester Hall, Columbia, MO, 65211, USA.
    Adolescents in rural and urban areas may experience different levels of environmental restrictions on alcohol use, with those in rural areas experiencing greater monitoring and less access to alcohol. Such restrictions may limit expression of genetic vulnerability for alcohol use, resulting in a gene-environment interaction (G × E). This phenomenon has previously been reported in Finnish and Minnesota adolescents. Read More

    Impaired Dopamine-Dependent Locomotory Behavior of C. elegans Neuroligin Mutants Depends on the Catechol-O-Methyltransferase COMT-4.
    Behav Genet 2017 11 6;47(6):596-608. Epub 2017 Sep 6.
    Department of Genetics, University of Córdoba, Córdoba, Spain.
    Neurexins and neuroligins are neuronal membrane adhesion molecules that have been involved in neuropsychiatric and neurodevelopmental disorders. The nrx-1 and nlg-1 genes of Caenorhabditis elegans encode NRX-1 and NLG-1, orthologue proteins of human neurexins and neuroligins, respectively. Dopaminergic and serotoninergic signalling control the locomotory rate of the nematode. Read More

    ACEt: An R Package for Estimating Dynamic Heritability and Comparing Twin Models.
    Behav Genet 2017 11 6;47(6):620-641. Epub 2017 Sep 6.
    Department of Mathematical Sciences, University of Oulu, Oulu, Finland.
    Estimating dynamic effects of age on the genetic and environmental variance components in twin studies may contribute to the investigation of gene-environment interactions, and may provide more insights into more accurate and powerful estimation of heritability. Existing parametric models for estimating dynamic variance components suffer from various drawbacks such as limitation of predefined functions. We present ACEt, an R package for fast estimating dynamic variance components and heritability that may change with respect to age or other moderators. Read More

    The Quinpirole Hypolocomotive Effects are Strain and Route of Administration Dependent in SHR and SLA16 Isogenic Rats.
    Behav Genet 2017 09 18;47(5):552-563. Epub 2017 Aug 18.
    Laboratory of Behavior Genetics, Department of Cellular Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianópolis, Brazil.
    The SHR and SLA16 inbred strains present behavioral differences in anxiety/emotionality that could be under the influence of dopaminergic neurotransmission. In order to investigate the role of D2 receptors in modulating such differences, an agonist (quinpirole) and an antagonist (haloperidol) of this receptor were administered, either via systemic injection (IP), or microinjected into the ventral area of the hippocampus (vHIP). Quinpirole and haloperidol IP decreased locomotor activity, only in SLA16 rats in the open-field (OF), and in both strains in the elevated plus-maze (EPM). Read More

    Age at Menarche and Time Spent in Education: A Mendelian Randomization Study.
    Behav Genet 2017 09 9;47(5):480-485. Epub 2017 Aug 9.
    Imperial College London, London, UK.
    Menarche signifies the primary event in female puberty and is associated with changes in self-identity. It is not clear whether earlier puberty causes girls to spend less time in education. Observational studies on this topic are likely to be affected by confounding environmental factors. Read More

    Sum Scores in Twin Growth Curve Models: Practicality Versus Bias.
    Behav Genet 2017 09 5;47(5):516-536. Epub 2017 Aug 5.
    Department of Psychology, University of Notre Dame, 220 C Haggar Hall, Notre Dame, IN, 46556, USA.
    To study behavioral or psychiatric phenotypes, multiple indices of the behavior or disorder are often collected that are thought to best reflect the phenotype. Combining these items into a single score (e.g. Read More

    Long-Term Follow-Up of Cognition and Mental Health in Adult Phenylketonuria: A PKU-COBESO Study.
    Behav Genet 2017 09 3;47(5):486-497. Epub 2017 Aug 3.
    Department of Clinical Child and Adolescent Studies & Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands.
    Cognitive and mental health problems in individuals with the inherited metabolic disorder phenylketonuria (PKU) have often been associated with metabolic control and its history. For the present study executive functioning (EF) was assessed in 21 PKU patients during childhood (T1, mean age 10.4 years, SD = 2. Read More

    Interaction between Parental Education and Twin Correlations for Cognitive Ability in a Norwegian Conscript Sample.
    Behav Genet 2017 09 25;47(5):507-515. Epub 2017 Jul 25.
    Norwegian Institute of Public Health, Oslo, Norway.
    We examine a sample of Norwegian twin conscripts for evidence of an interaction between parental education and the heritability of general cognitive ability (GA). Ability scores were obtained on 1706 pairs of twins who were conscripted into the Norwegian Armed Forces between 1931and 1960. Education scores were available for mothers and fathers; the majority of the parents had less than a high school education. Read More

    Methylphenidate and Atomoxetine-Responsive Prefrontal Cortical Genetic Overlaps in "Impulsive" SHR/NCrl and Wistar Rats.
    Behav Genet 2017 09 25;47(5):564-580. Epub 2017 Jul 25.
    Department of Pharmacy, Uimyung Research Institute for Neuroscience, Sahmyook University, 26-21 Kongreung-2-dong, Hwarangro-815, Nowon-gu, Seoul, 139-742, Republic of Korea.
    Impulsivity, the predisposition to act prematurely without foresight, is associated with a number of neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD). Identifying genetic underpinnings of impulsive behavior may help decipher the complex etiology and neurobiological factors of disorders marked by impulsivity. To identify potential genetic factors of impulsivity, we examined common differentially expressed genes (DEGs) in the prefrontal cortex (PFC) of adolescent SHR/NCrl and Wistar rats, which showed marked decrease in preference for the large but delayed reward, compared with WKY/NCrl rats, in the delay discounting task. Read More

    Conservation of Phenotypes in the Roman High- and Low-Avoidance Rat Strains After Embryo Transfer.
    Behav Genet 2017 09 17;47(5):537-551. Epub 2017 Jul 17.
    Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, Institute of Neurosciences, School of Medicine, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.
    The Roman high- (RHA-I) and low-avoidance (RLA-I) rat strains are bi-directionally bred for their good versus non-acquisition of two-way active avoidance, respectively. They have recently been re-derived through embryo transfer (ET) to Sprague-Dawley females to generate specific pathogen free (SPF) RHA-I/RLA-I rats. Offspring were phenotyped at generations 1 (G1, born from Sprague-Dawley females), 3 and 5 (G3 and G5, born from RHA-I and RLA-I from G2-G4, respectively), and compared with generation 60 from our non-SPF colony. Read More

    Contributions of Genes and Environment to Developmental Change in Alcohol Use.
    Behav Genet 2017 09 17;47(5):498-506. Epub 2017 Jul 17.
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
    The precise nature of how genetic and environmental risk factors influence changes in alcohol use (AU) over time has not yet been investigated. Therefore, the aim of the present study is to examine the nature of longitudinal changes in these risk factors to AU from mid-adolescence through young adulthood. Using a large sample of male twins, we compared five developmental models that each makes different predictions regarding the longitudinal changes in genetic and environmental risks for AU. Read More

    Single Nucleotide Polymorphisms Associated with Reading Ability Show Connection to Socio-Economic Outcomes.
    Behav Genet 2017 09 15;47(5):469-479. Epub 2017 Jul 15.
    Department of Psychology, School of Philosophy, Psychology and Language Sciences, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
    Impairments in reading and in language have negative consequences on life outcomes, but it is not known to what extent genetic effects influence this association. We constructed polygenic scores for difficulties with language and learning to read from genome-wide data in ~6,600 children, adolescents and young adults, and tested their association with health, socioeconomic outcomes and brain structure measures collected in adults (maximal N = 111,749). Polygenic risk of reading difficulties was associated with reduced income, educational attainment, self-rated health and verbal-numerical reasoning (p < 0. Read More

    Higher Rates of DZ Twinning in a Twenty-First Century Birth Cohort.
    Behav Genet 2017 09 15;47(5):581-584. Epub 2017 Jul 15.
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.
    The Colorado Twin Registry is a population based registry initiated in 1984 with the involvement of the Colorado Department of Health, Division of Vital Statistics. Recruitment includes birth cohorts several years prior to 1984 and all subsequent years. As part of a recent evaluation of Colorado birth records for the years 2006 through 2008 we became aware of a shifting trend in the proportion of MZ and DZ twins in the Colorado population. Read More

    Rsk2 Knockout Affects Emotional Behavior in the IntelliCage.
    Behav Genet 2017 Jul 6;47(4):434-448. Epub 2017 Jun 6.
    Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Wuerzburg, Margarete-Höppel-Platz 1, 97080, Wuerzburg, Germany.
    Ribosomal s6 kinase 2 is a growth factor activated serine/threonine kinase and member of the ERK signaling pathway. Mutations in the Rsk2 gene cause Coffin-Lowry syndrome, a rare syndromic form of intellectual disability. The Rsk2 KO mouse model was shown to have learning and memory defects. Read More

    A Family-Based Study of the Association Between Labor Induction and Offspring Attention-Deficit Hyperactivity Disorder and Low Academic Achievement.
    Behav Genet 2017 Jul 27;47(4):383-393. Epub 2017 May 27.
    Department of Psychological and Brain Sciences, Indiana University, 1101 E. 10th St., Bloomington, IN, 47405, USA.
    The current study examined associations between labor induction and both (1) offspring attention-deficit hyperactivity disorder (ADHD) diagnosis in a Swedish birth cohort born 1992-2005 (n = 1,085,008) and (2) indices of offspring low academic achievement in a sub-cohort born 1992-1997 (n = 489,196). Associations were examined in the entire sample (i.e. Read More

    Genetic and Environmental Influences on Longitudinal Trajectories of Functional Biological Age: Comparisons Across Gender.
    Behav Genet 2017 Jul 27;47(4):375-382. Epub 2017 May 27.
    Institute of Gerontology, School of Health and Welfare, Jönköping University, Box 1026, 551 11, Jönköping, Sweden.
    We used an alternate age variable, functional biological age (fBioAge), which was based on performance on functional body measures. The aim was to examine development of fBioAge across the adult life span, and to also examine potential gender differences and genetic and environmental influences on change with age. We used longitudinal data (n = 740; chronological age (ChronAge) range 45-85 at baseline) from the Swedish Adoption/Twin Study of Aging. Read More

    Pleiotropic Effects of DDT Resistance on Male Size and Behaviour.
    Behav Genet 2017 Jul 2;47(4):449-458. Epub 2017 May 2.
    Biosciences, University of Exeter, Penryn Campus, Penryn, TR10 9FE, Cornwall, UK.
    Understanding the evolution and spread of insecticide resistance requires knowing the relative fitness of resistant organisms. In the absence of insecticides, resistance is predicted to be costly. The Drosophila melanogaster DDT resistance allele (DDT-R) is associated with a male mating cost. Read More

    Cannabis and Depression: A Twin Model Approach to Co-morbidity.
    Behav Genet 2017 Jul 2;47(4):394-404. Epub 2017 May 2.
    National Addiction Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, Addiction Sciences Building, 4 Windsor Walk, SE5 8BB, London, UK.
    Cannabis use disorder (CUD) co-occurs with major depressive disorder (MDD) more frequently than would be expected by chance. However, studies to date have not produced a clear understanding of the mechanisms underlying this co-morbidity. Genetically informative studies can add valuable insight to this problem, as they allow the evaluation of competing models of co-morbidity. Read More

    Decoupling of Behavioral Trait Correlation Across Life Stages in Two Holometabolous Insects.
    Behav Genet 2017 Jul 18;47(4):459-467. Epub 2017 Apr 18.
    Laboratory of Evolutionary Ecology, Graduate School of Environmental and Life Science, Okayama University, Okayama, Japan.
    Many animal behaviors have a genetic base, and behavioral traits often correlate with one another. In this study, we tested for a behavioral correlation between tonic immobility and walking distance in the larval and adult stages independently of two holometabolous insects. We confirmed a negative correlation of traits between strains in adults of both the species; however, we did not find it in larvae of either species. Read More

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