25,595 results match your criteria Bedside Ultrasonography Trauma Evaluation


Protective effect of forsythoside B against lipopolysaccharide-induced acute lung injury by attenuating the TLR4/NF-κB pathway.

Int Immunopharmacol 2018 Dec 3;66:336-346. Epub 2018 Dec 3.

Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, China. Electronic address:

Acute lung injury (ALI), which is mainly triggered by infection, pneumonia, vasculitis, and sepsis, has no specific and effective therapy except for primary supportive treatment or bedside care. Excessive inflammation caused by innate immune cells is the major characteristic of ALI. Forsythoside B, a phenylethanoside compound, possesses good antioxidant and anti-bacterial properties in vivo and in vitro. Read More

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December 2018
2 Reads
2.472 Impact Factor

Does the experience of the bedside assistant effect the results of robotic surgeons in the learning curve of robot assisted radical prostatectomy?

Int Braz J Urol 2018 Oct 20;44. Epub 2018 Oct 20.

American Hospital, Istanbul, Turkey.

Introduction: The success of the robot assisted radical prostatectomy (RARP) procedures depend on a successful team, however the literature focuses on the performance of a console surgeon. The aim of this study was to evaluate surgical outcomes of the surgeons during the learning curve in relation to the bedside assistant's experience level during RARP.

Materials And Methods: We retrospectively reviewed two non - laparoscopic, beginner robotic surgeon's cases, and we divided the patients into two groups. Read More

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October 2018
2 Reads

Cardiovascular Risk Factors and Brain Health: Impact on Long-Range Cortical Connections and Cognitive Performance.

J Am Heart Assoc 2018 Dec;7(23):e010054

1 Department of Neurology Medical University of South Carolina Charleston SC.

Background Cardiovascular risk factor burden in the absence of clinical or radiological "events" is associated with mild cognitive impairment. Magnetic resonance imaging techniques exploring the integrity of neuronal fiber connectivity within white matter networks supporting cognitive processing could be used to measure the impact of cardiovascular disease on brain health and be used beyond bedside neuropsychological tests to detect subclinical changes and select or stratify participants for entry into clinical trials. Methods and Results We assessed the relationship between verbal IQ and brain network integrity and the effect of cardiovascular risk factors on network integrity by constructing whole-brain structural connectomes from magnetic resonance imaging diffusion images (N=60) from people with various degrees of cardiovascular risk factor burden. Read More

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December 2018
2 Reads

Mindfulness and burnout among beside registered nurses: A cross-sectional study.

Nurs Health Sci 2018 Dec 6. Epub 2018 Dec 6.

Quality Management Office, the Second Hospital of Shandong University, Jinan, China.

Nursing is a high stress job, and burnout of nurses is of particular concern. The aim of this cross-sectional survey study was to examine the relationship between mindfulness and burnout, and how the mindfulness facets vary in their associations with the different domains of burnout for Chinese nurses. A sample of registered bedside nurses working in a tertiary Chinese hospital (n = 763) was surveyed from February to June 2017 regarding mindfulness (i. Read More

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December 2018

Stroke: The past, present and future.

Brain Neurosci Adv 2018 ;2:2398212818810689

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Since the inception of the British Neuroscience Association, there have been major advances in our knowledge of the mechanistic basis for stroke-induced brain damage. Identification of the ischaemic cascade led to the development of hundreds of new drugs, many showing efficacy in preclinical (animal-based) studies. None of these drugs has yet translated to a successful stroke treatment, current therapy being limited to thrombolysis/thrombectomy. Read More

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January 2018

Diagnostic laparoscopy to investigate unexplained lactic acidosis in critically ill patients - A descriptive single centre cohort study.

Ann Med Surg (Lond) 2018 Dec 13;36:231-234. Epub 2018 Nov 13.

Department of Surgery, University Hospital Hairmyres, NHS Lanarkshire, East Kilbride, G75 8RG, Scotland, UK.

Introduction: Unexplained lactic acidosis (LA) in a critically ill patient often prompts investigations to rule out any reversible intra-abdominal cause. Equivocal results can lead to an emergency laparotomy (EL) with subsequent high morbidity and mortality rates. Our objective was to determine the clinical impact of urgent diagnostic laparoscopy (UDL) in such patients. Read More

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December 2018
1 Read

Structured interdisciplinary bedside rounds, in-hospital deaths, and new nursing home placements among older inpatients.

Clin Interv Aging 2018 8;13:2289-2294. Epub 2018 Nov 8.

Department of Geriatric Medicine, Centre for Applied Nursing Research, Western Sydney University and Ingham Institute of Applied Medical Research, Aged Care Research Unit, Liverpool Hospital, Liverpool BC, NSW 1871, Australia.

Purpose: Ineffective interdisciplinary communication is linked to many adverse consequences of hospitalization. This study evaluated the effect of SIBR, a model of care that encourages interdisciplinary communication and patient and family participations, on in-hospital deaths and new nursing home (NH) placements.

Materials And Methods: This before-after study included 3,673 consecutive inpatients of mean age 83. Read More

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November 2018
1.824 Impact Factor

Patient safety after implementation of a coproduced family centered communication programme: multicenter before and after intervention study.

BMJ 2018 Dec 5;363:k4764. Epub 2018 Dec 5.

Harvard Medical School, Boston, MA, USA.

Objective: To determine whether medical errors, family experience, and communication processes improved after implementation of an intervention to standardize the structure of healthcare provider-family communication on family centered rounds.

Design: Prospective, multicenter before and after intervention study.

Setting: Pediatric inpatient units in seven North American hospitals, 17 December 2014 to 3 January 2017. Read More

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December 2018

Extravascular lung water monitoring for thoracic and lung transplant surgeries.

Curr Opin Anaesthesiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Anesthesiology, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT.

Purpose Of Review: Excessive accumulation of extravascular lung water (EVLW) resulting in pulmonary edema is the most feared complication following thoracic surgery and lung transplant. ICUs have long relied on chest radiography to monitor pulmonary status postoperatively but the increasing recognition of the limitations of bedside plain films has fueled development of newer technologies, which offer earlier detection, quantitative assessments, and can aide in preoperative screening of surgical candidates. In this review, we focus on the emergence of transpulmonary thermodilution (TPTD) and lung ultrasound with a focus on the clinical integration of these modalities into current intraoperative and critical care practices. Read More

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November 2018

Clinical Education to Decrease Perceived Barriers to Delirium Screening in Adult Intensive Care Units.

Crit Care Nurs Q 2019 Jan/Mar;42(1):41-43

Medical University of South Carolina, Charleston.

Despite current advances in critical care medicine, delirium remains a frequent complication of an intensive care unit stay. The consequences can be severe and far reaching, including an increase in mortality, length of stay, and long-term cognitive sequelae. Frequently, delirium can be missed by clinicians who fail to complete a standardized delirium screening tool and, therefore, many cases go unrecognized and untreated. Read More

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December 2018

Tefillin use induces remote ischemic preconditioning pathways in healthy men.

Am J Physiol Heart Circ Physiol 2018 Dec 14;315(6):H1748-H1758. Epub 2018 Sep 14.

Division of Cardiovascular Health and Disease, Department of Medicine, University of Cincinnati , Cincinnati, Ohio.

The present study assessed whether tefillin use (tight, nonocclusive, wrapping of the arm) elicits a remote ischemic preconditioning (RIPC)-like effect in subjects with both acute and chronic use. RIPC, created by short bursts of ischemia-reperfusion, has not been successfully taken to the bedside. Several large population studies have found that Orthodox Jewish men (who wear tefillin almost daily) have decreased cardiovascular mortality compared with non-Orthodox counterparts. Read More

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December 2018
2 Reads

Childhood trauma exposure and gun violence risk factors among victims of gun violence.

Psychol Trauma 2018 Dec 3. Epub 2018 Dec 3.

Southeastern Louisiana Veterans Health Care System.

Objective: Gun violence is a serious public health concern, yet risk factors for gun violence involvement remain understudied. Childhood trauma exposure, such as domestic violence (DV) and community violence (CV), may increase the risk for aggression, although this relationship has not been examined in the context of gun violence. The aim of the current study was to investigate whether different childhood trauma ecologies are related to increased gun violence involvement and gun violence risk factors among individuals hospitalized for a gun injury. Read More

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December 2018

Spectral-Domain OCT Findings of Retinal Vascular-Avascular Junction in Infants with Retinopathy of Prematurity.

Ophthalmol Retina 2018 Sep 21;2(9):963-971. Epub 2018 Mar 21.

Department of Ophthalmology, Duke University, Durham, NC, 27710, USA.

Purpose: Bedside examination of premature infants at risk for retinopathy of prematurity (ROP) is predominantly performed with ophthalmoscopic viewing of the retina. While postmortem retinal microstructures have been studied at the vascular-avascular junction, a critical location for pathogenesis of ROP, to date this has not been possible . Here we present bedside, non-sedated cross-sectional imaging and analysis of retinal microstructures at the vascular-avascular junction in infants with ROP using handheld spectral-domain optical coherence tomography (SDOCT). Read More

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September 2018
1 Read

Bedside Nurse Acceptance of Intensive Care Unit Telemedicine Presence.

Crit Care Nurse 2018 Dec;38(6):e1-e4

Christina Canfield is the program manager for Cleveland Clinic's intensive care unit telemedicine program, Cleveland, Ohio. Sandra Galvin is the nurse manager of the coronary intensive care unit and the heart failure intensive care unit at Cleveland Clinic Main Campus.

Since 2010, health care organizations have rapidly adopted telemedicine as part of their health care delivery system to inpatients and outpatients. The application of telemedicine in the intensive care unit is often referred to as In telemedicine, nurses, nurse practitioners, physicians, and other health care professionals provide patient monitoring and intervention from a remote location. Tele-ICU presence has demonstrated positive outcomes such as increased adherence to evidence-based care and improved perception of support at the bedside. Read More

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December 2018

Interprofessional Approach to the Sustained in a Pediatric Intensive Care Unit.

Crit Care Nurse 2018 Dec;38(6):36-45

Cheryl Lynne McBeth is a nurse manager for the pediatric intensive care unit (PICU), pediatric cardiac intensive care unit (PCICU), and Critical Care Transport Team, University of California, Davis, Children's Hospital, Sacramento, California. Rosa Solis Montes is clinical nurse III, University of California, Davis, Children's Hospital. She has been the cochair or chair of the No VAP committee since 2010. Amy Powne is Fetal Care and Treatment Center registered nurse coordinator at University of California, Davis, Children's Hospital. Sopon Elizabeth North is clinical nurse III, University of California, Davis, Children's Hospital. She currently is chair of the PICU/PCICU Hospital-Acquired Infection Committee. JoAnne E. Natale is professor of clinical pediatrics, Pediatric Critical Care, Children's Hospital Quality & Safety, and director of quality and safety, University of California, Davis, Medical Center.

Background: Ventilator-associated pneumonia (VAP) increases morbidity, mortality, and health care costs.

Objective: To reduce the VAP rate in the pediatric/cardiac intensive care unit to fewer than 2 events per 1000 ventilator days within 2 years and to sustain a rate near 0 for the next 5 years.

Methods: An evidence-based VAP prevention bundle was developed and implemented by an interprofessional team using the Six Sigma Define, Measure, Analyze, Improve, Control methodology. Read More

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December 2018

Factors Predicting Ventriculostomy Revision at a Large Academic Medical Center.

World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurosurgery, The University of Pennsylvania, 3400 Spruce Street, Silverstein Pavilion 3rd Floor, Philadelphia, PA, USA 19104.

Background: Freehand bedside ventriculostomy placement can result in catheter malfunction requiring a revision procedure and cause significant patient morbidity. We performed a single-center retrospective review to assess factors related to this complication.

Methods: Using an administrative database and chart review, we identified 101 first-time EVD placements performed at the bedside. Read More

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November 2018

Nonoperative management of giant omphalocele leading to early fascial closure.

J Pediatr Surg 2018 Dec 2;53(12):2404-2408. Epub 2018 Sep 2.

Sunrise Children's Hospital, Las Vegas, NV.

Purpose: We describe our series of giant omphalocele patients treated with a serial taping method for gradual reduction of the abdominal contents and early fascial closure.

Methods: Between 2010 and 2017 we cared for ten newborns with giant omphaloceles. The average gestational age was 35. Read More

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December 2018
1 Read

Impact of bedside diagnosis of influenza in the paediatric emergency ward.

Clin Microbiol Infect 2018 Nov 28. Epub 2018 Nov 28.

Groupe Immunité des Muqueuses et Agents Pathogènes (GIMAP), EA3064, Faculty of Medicine of Saint-Etienne, University of Lyon, France; Laboratory of Infectious agents and Hygiene, University Hospital of Saint-Etienne, France.

Objectives: This prospective study performed in the paediatric emergency department of the University Hospital of Saint-Etienne aimed to measure the impact of the 24/7 bedside use of the Veritor™ System (Becton Dickinson) on the reduction of supplementary investigations, hospital stay and antimicrobial use.

Methods: Influenzavirus A and B antigens were detected with a rapid influenza digital immunoassay (DIA) on nasopharyngeal aspirates (NPA) sampled from the children consulting at the paediatric emergency department between January and March 2016 for influenza-like illness. The same NPA was tested by immunofluorescence and/or molecular routine assays. Read More

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November 2018
1 Read

Exploring bedside clinical features of parkinsonism: A focus on differential diagnosis.

Parkinsonism Relat Disord 2018 Nov 5. Epub 2018 Nov 5.

Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA.

The proper diagnosis of parkinsonian disorders usually involves three steps: identifying core features of parkinsonism; excluding other causes; and collating supportive evidence based on clinical signs or investigations. While the recognition of cardinal parkinsonian features is usually straightforward, the appreciation of clinical features suggestive of specific parkinsonian disorders can be challenging, and often requires greater experience and skills. In this review, we outline the clinical features that are relevant to the differential diagnosis of common neurodegenerative parkinsonian disorders, including Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration. Read More

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November 2018
1 Read

Ice Pack Test - An Useful Bedside Test to Diagnose Myasthenia Gravis.

QJM 2018 Dec 4. Epub 2018 Dec 4.

Neurology Unit, Department of Internal Medicine, Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia.

Myasthenia gravis is a common autoimmune neurological disorder that is frequently encountered in our daily practice. Its presentation can vary from ocular myasthenia, generalized myasthenia to myasthenia crisis. Diagnosing a myasthenia crisis is especially challenging in an intubated patient. Read More

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December 2018

Multimodality Monitoring in the Neurocritical Care Unit.

Continuum (Minneap Minn) 2018 Dec;24(6):1776-1788

Purpose Of Review: This article focuses on the multiple neuromonitoring devices that can be used to collect bedside data in the neurocritical care unit and the methodology to integrate them into a multimodality monitoring system. The article describes how to apply the collected data to appreciate the physiologic changes and develop therapeutic approaches to prevent secondary injury.

Recent Findings: The neurologic examination has served as the primary monitor for secondary brain injury in patients admitted to the neurocritical care unit. Read More

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December 2018

Cerebral Edema and Elevated Intracranial Pressure.

Authors:
Matthew A Koenig

Continuum (Minneap Minn) 2018 Dec;24(6):1588-1602

Purpose Of Review: This article reviews the management of cerebral edema, elevated intracranial pressure (ICP), and cerebral herniation syndromes in neurocritical care.

Recent Findings: While corticosteroids may be effective in reducing vasogenic edema around brain tumors, they are contraindicated in traumatic cerebral edema. Mannitol and hypertonic saline use should be tailored to patient characteristics including intravascular volume status. Read More

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December 2018

Robotic Thoracic Surgery Training for Residency Programs: A Position Paper for an Educational Curriculum.

Innovations (Phila) 2018 Dec 3. Epub 2018 Dec 3.

Department of General Surgery, Brookdale University Hospital and Medical Center, Brooklyn, NY USA.

Objective: Robotic-assisted surgery is increasingly being used in thoracic surgery. Currently, the Integrated Thoracic Surgery Residency Program lacks a standardized curriculum or requirement for training residents in robotic-assisted thoracic surgery. In most circumstances, because of the lack of formal residency training in robotic surgery, hospitals are requiring additional training, mentorship, and formal proctoring of cases before granting credentials to perform robotic-assisted surgery. Read More

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December 2018
5 Reads

A Descriptive, Qualitative Study to Explore the Pain Experience During Negative Pressure Wound Therapy for Postsurgical Abdominal Wounds.

Ostomy Wound Manage 2018 Dec;64(12):38-48

Trakya University, Edime, Turkey.

Pain during negative pressure wound therapy (NPWT) has been reported in the literature.

Purpose: The study was conducted to describe patients' pain experience, pain-coping skills, and the effect of NPWT-related pain on daily life activities following abdominal surgery.

Method: Using a descriptive, qualitative design, semi-structured face-to-face interviews were conducted between April 3, 2016 and December 26, 2016, in the surgical ward of a university hospital in Edirne, Turkey. Read More

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December 2018
1 Read

Considerations for translation of tissue engineered fibrocartilage from bench to bedside.

J Biomech Eng 2018 Dec 5. Epub 2018 Dec 5.

ASME Fellow, Distinguished Professor, Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697.

Fibrocartilage is found in the knee meniscus, the temporomandibular joint (TMJ) disc, the pubic symphysis, the annulus fibrosus of intervertebral disc, tendons, and ligaments. These tissues are notoriously difficult to repair due to their avascularity, and limited clinical repair and replacement options exist. Tissue engineering has been proposed as a route to repair and replace fibrocartilages. Read More

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December 2018

Rapid tissue viability evaluation using methemoglobin as a biomarker in burns.

Int J Burns Trauma 2018 20;8(5):126-134. Epub 2018 Oct 20.

Department of Plastic Surgery, St. Michael's Hospital Toronto, ON, Canada.

Burns are a frequent cause of traumatic injury, accounting for an average of 1,230 visits to the emergency department every day in the United States. While many of these injuries will heal spontaneously, nearly 1 in 10 are severe enough to require hospitalization or transfer to a specialized burn center. The early surgical management of a severe burn is critical to patient outcome, but few tools exist for triaging viable and non-viable tissue at early time-points post-injury. Read More

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October 2018
3 Reads

Healthcare costs and outcomes for patients undergoing tracheostomy in an Australian tertiary level referral hospital.

J Intensive Care Soc 2018 Nov 5;19(4):305-312. Epub 2018 Mar 5.

Department of ICCU, Flinders Medical Centre, Bedford Park, SA, Australia.

Objective: Patients undergoing tracheostomy represent a unique cohort, as often they have prolonged hospital stay, require multi-disciplinary, resource-intensive care, and may have poor outcomes. Currently, there is a lack of data around overall healthcare cost for these patients and their outcomes in terms of morbidity and mortality. The objective of the study was to estimate healthcare costs and outcomes associated in tracheostomy patients at a tertiary level hospital in South Australia. Read More

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November 2018

[Prognostic value of difference between peripheral venous and arterial partial pressure of carbon dioxide in patients with septic shock: a pilot study].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1312-1317

Department of Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.

Objective: To evaluate the prognostic value of the difference between peripheral venous and arterial partial pressure of carbon dioxide in patients with septic shock following early resuscitation.

Methods: This prospective study was conducted among the patients with septic shock treated in our department during the period from May, 2017 to May, 2018. Peripheral venous, peripheral arterial and central venous blood samples were collected simultaneously and analyzed immediately at bedside after 6-h bundle treatment. Read More

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November 2018

A Targeted Swallow Screen for the Detection of Postoperative Dysphagia in Liver Transplant Patients.

Prog Transplant 2018 Dec 4:1526924818817035. Epub 2018 Dec 4.

1 Division of Cardiac Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Introduction:: Postoperative dysphagia leads to aspiration pneumonia, prolonged hospital stay, and is associated with increased mortality. We have demonstrated the validity of a bedside targeted swallow evaluation following cardiac surgery. Since dysphagia following liver transplantation is not well examined, we evaluated the efficacy of this swallow screen method in postoperative liver transplant patients. Read More

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December 2018

Bedside Ultrasound Assessment of Lung Reaeration in Patients With Blunt Thoracic Injury Receiving High-Flow Nasal Cannula Oxygen Therapy: A Retrospective Study.

J Intensive Care Med 2018 Dec 4:885066618815649. Epub 2018 Dec 4.

1 Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background:: High-flow nasal cannula (HFNC) oxygen therapy has been shown to reduce the need for mechanical ventilation and decrease the duration of hospital and intensive care unit (ICU) stays for patients with a severely compromised respiratory system. This study aims to observe the evolution of lung aeration via lung ultrasound score (LUS) in a chest-injured population who had been treated with HFNC oxygen therapy, and to assess the benefit of the HFNC oxygen therapy in trauma patients.

Methods:: A retrospective study examined trauma patients with moderate to severe thoracic injuries who were admitted to the ICU at a tertiary hospital between October 2015 and March 2017. Read More

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December 2018

Covert Consciousness: Searching for Volitional Brain Activity in the Unresponsive.

Authors:
Brian L Edlow

Curr Biol 2018 Dec;28(23):R1345-R1348

Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, 175 Cambridge Street - Suite 300, Boston, MA 02114, USA. Electronic address:

Consciousness may evade detection by bedside behavioral examination. New research suggests that an electrophysiologic screening tool can identify people with severe brain injuries who are likely to be covertly conscious. Read More

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December 2018
1 Read

Is the LICOX® PtO system reliable for monitoring of free flaps? Comparison between two cohorts of patients.

Microsurgery 2018 Dec 4. Epub 2018 Dec 4.

Department of Medical, Surgical and Health Sciences, Plastic and Reconstructive Surgery Unit, University of Trieste, Trieste, Italy.

Background: Licox® PtO is a minimally invasive monitoring system for continuous measurement of tissue oxygen tension in all types of free tissue transfers. Our study compares two consecutive series of patients undergoing microsurgical reconstruction monitored with standard clinical bedside surveillance and with the Licox® PtO system regarding flap loss and flap salvage, the sensitivity, specificity, and cost-effectiveness.

Methods: We performed a longitudinal observational prospective study of all patients undergoing microsurgical reconstructions between 2016 and 2017. Read More

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December 2018
2 Reads

High alert medications administration errors in neonatal intensive care unit: A pediatric tertiary hospital experience.

Turk J Pediatr 2018 ;60(3):277-285

Departments of Public Health Faculty of Medicine, Cairo University, Egypt.

Labib JR, Youssef MRL, Abd El Fatah SAM. High alert medications administration errors in neonatal intensive care unit: A pediatric tertiary hospital experience. Turk J Pediatr 2018; 60: 277-285. Read More

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January 2018

Revisiting the Concept of Subjective Tolerability to Antipsychotic Medications in Schizophrenia and its Clinical and Research Implications: 30 Years Later.

Authors:
A George Awad

CNS Drugs 2018 Dec 3. Epub 2018 Dec 3.

Professor Emeritus, Department of Psychiatry and the Institute of Medical Science, Humber River Hospital, University of Toronto, 1235 Wilson Avenue, Toronto, ON, M3M 0B2, Canada.

Schizophrenia is a long-term psychiatric disorder that impacts important mental functions and requires indefinite treatment, as well as psychosocial and economic support. The introduction of chlorpromazine, the first antipsychotic, and the subsequent development of a long list of similar dopamine-blocking antipsychotic medications, has changed the treatment of schizophrenia as medications have become the cornerstone of clinical management. The enthusiasm that greeted the introduction of antipsychotics was soon tempered by the realisation that they induced significant side effects, such as extrapyramidal and autonomic symptoms. Read More

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December 2018
1 Read

Spontaneous splenic rupture in Plasmodium knowlesi malaria.

Malar J 2018 Dec 4;17(1):448. Epub 2018 Dec 4.

Malaria Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.

Background: Plasmodium knowlesi, a malaria parasite typically found in long-tailed and pig-tailed macaques, is the most common cause of human malaria in Malaysian Borneo. Infections in humans result in a spectrum of disease, including fatal outcomes. Spontaneous splenic rupture is a rare, but severe complication of malaria and has not been reported previously for knowlesi malaria. Read More

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December 2018

MicroRNAs in gastric cancer: from bench to bedside.

Neoplasma 2018 Sep 29. Epub 2018 Sep 29.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.

Gastric carcinogenesis is the result of complex interactions among host, environmental and bacterial factors, which lead to genetic and epigenetic dysregulation of oncogenic and tumor-suppressive genes. MicroRNAs (miRNAs), a class of small noncoding RNAs, regulate about 30% of human genes post transcriptionally and emerge as crucial regulators in the initiation and progression of various diseases, particularly malignancies. Accumulating evidence documented changes in different levels, such as gene sequence and epigenetic modification could lead to the abnormal expression of miRNAs in gastric cancer (GC), and the dysregulated miRNAs, which acted as oncogenes or tumor suppressors through regulating related target genes, contributed to malignant phenotypes. Read More

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September 2018
4 Reads

Formation of Microbubbles for Targeted Ultrasound Contrast Imaging: Practical Translation Considerations.

Langmuir 2018 Dec 3. Epub 2018 Dec 3.

For preparation of ligand-decorated microbubbles for targeted ultrasound contrast imaging it is important to maximize the amount of ligand associated with the bubble shell. We describe optimization of the use of a biocompatible co-surfactant in the microbubble formulation media to maximize the incorporation of targeting ligand-lipid conjugate into the microbubble shell, and thus reduce the fraction of ligand not associated with microbubbles, following amalgamation preparation. The influence of the concentration of a helper co-surfactant propyleneglycol (PG) on the efficacy of microbubble preparation by amalgamation and on the degree of association of fluorescent PEG-lipid with the microbubble shell was tested. Read More

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December 2018

Integrating Research and Quality Improvement Using TeamSTEPPS: A Health Team Communication Project to Improve Hospital Discharge.

Clin Nurse Spec 2019 Jan/Feb;33(1):22-32

Author Affiliations: Clinical Nurse Specialist, Froedtert Hospital (Mr Beiler and Ms Opper); and Professor, Marquette University College of Nursing, Milwaukee, Wisconsin (Dr Weiss).

Purpose/objectives: The purpose of this article is to describe an innovative approach to the integration of quality improvement and research processes. A project with the objective of improving health team communication about hospital discharge provides an exemplar case.

Description Of The Project/program: The TeamSTEPPS 10-step action planning guide provided the structure for planning, developing, and evaluating a redesign of interprofessional health team communication to improve hospital discharge led by 2 clinical nurse specialists. Read More

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December 2018

A Partially Structured Postoperative Handoff Protocol Improves Communication in 2 Mixed Surgical Intensive Care Units: Findings From the Handoffs and Transitions in Critical Care (HATRICC) Prospective Cohort Study.

Ann Surg 2018 Nov 29. Epub 2018 Nov 29.

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Objective: To assess the effectiveness of standardizing operating room (OR) to intensive care unit (ICU) handoffs in a mixed surgical population.

Summary Of Background Data: Standardizing OR to ICU handoffs improves information transfer after cardiac surgery, but there is limited evidence in other surgical contexts.

Methods: This prospective interventional cohort study (NCT02267174) was conducted in 2 surgical ICUs in 2 affiliated hospitals. Read More

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November 2018
3 Reads

Creating a Culture of Promoting From Within.

Authors:
Brian W Jones

Dimens Crit Care Nurs 2019 Jan/Feb;38(1):50-53

Brian W. Jones, DHSc, is president/CEO of SHARE Foundation, El Dorado, Arizona.

Although it is common to promote direct care nurses to management positions in nursing, it is important to have a well-defined process. Excelling in clinical skills at the bedside does not always translate into management and leadership abilities. Having a way to internally identify and develop frontline leaders for future management positions is important in succession planning, creating organizational culture, decreasing costs, and increasing employee engagement. Read More

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December 2018

Robot-Assisted Surgery for Benign Distal Ureteral Strictures: Step-by-Step Technique Using the SP Surgical System.

BJU Int 2018 Nov 30. Epub 2018 Nov 30.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.

Objectives: To describe the step-by-step techniques for robotic ureteral reimplantation performed by using the Vinci SP surgical system (Intuitive Surgical, Sunnyvale, CA). Different case-scenarios were included with an educational purpose.

Materials And Methods: Three consecutive patients diagnosed with distal benign ureteral strictures were counseled for ureteral reimplantation and accepted to undergo surgery performed by using the da Vinci SP surgical system. Read More

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November 2018
8 Reads

Fostering self-determination of bedside providers to promote active participation in rapid response events.

Med Educ Online 2019 Dec;24(1):1551028

f Section of Critical Care Medicine and Center for Research, Innovation and Scholarship in Medical Education, Department of Pediatrics , Baylor College of Medicine , Houston , Texas , USA.

Background: Widespread implementation of rapid response (RR) systems positively impacts outcomes of clinically unstable hospitalized patients. Collaboration between bedside providers and specialized responding teams is crucial for effective functioning of RR system. Bedside, providers often harbor negative feelings about having to 'call for help' that could impact their active participation in RR. Read More

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December 2019

Protein PEGylation for cancer therapy: bench to bedside.

J Cell Commun Signal 2018 Nov 29. Epub 2018 Nov 29.

Cancer Research Unit, VA Medical Center, Kansas City, MO, 64128, USA.

PEGylation is a biochemical modification process of bioactive molecules with polyethylene glycol (PEG), which lends several desirable properties to proteins/peptides, antibodies, and vesicles considered to be used for therapy or genetic modification of cells. However, PEGylation of proteins is a complex process and can be carried out using more than one strategy that depends on the nature of the protein and the desired application. Proteins of interest are covalently conjugated or non-covalently complexed with inert PEG strings. Read More

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November 2018
3 Reads

Diabetes and antiplatelet therapy: from bench to bedside.

Cardiovasc Diagn Ther 2018 Oct;8(5):594-609

Division of Cardiology, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA.

Diabetes mellitus (DM) is a metabolic disorder associated with accelerated atherogenesis and an increased risk of atherothrombotic complications. Multiple mechanisms contribute to the pro-thrombotic status which characterizes DM patients underscoring the importance of antiplatelet therapies used for secondary prevention in these patients. For many years, dual antiplatelet therapy (DAPT) with aspirin and the P2Y inhibitor clopidogrel has represented the mainstay of treatment following an acute coronary syndrome (ACS) or in patients undergoing percutaneous coronary interventions (PCI). Read More

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October 2018

Bioactive Small Molecules in the Pathogenesis and Pharmacology of Cardiovascular Diseases: From Bench to Bedside.

Authors:
Lihui Jin Yu Yu

Curr Top Med Chem 2018 ;18(16):1351-1353

Department of Pediatric Cardiovascular, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.

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January 2018
2 Reads

Optimizing survival of large fibula osteocutaneous flaps for extensive full-thickness oromandibular defects: A two-stage approach with temporary orocutaneous fistula.

Microsurgery 2018 Nov 29. Epub 2018 Nov 29.

Department of Plastic and Reconstructive Surgery, China Medical University, Taichung, Taiwan.

Introduction: Composite and large head and neck defects requiring extensive skin-mucosa coverage are often reconstructed by combining flaps. Herein, we present a simple and reliable two-stage fibula osteocutaneous (FOC) flap technique to improve the survival of a large skin paddle for oromandibular reconstructions.

Methods: From October 2011 to September 2016, 47 patients with through-and-through oromandibular defects were reconstructed using FOC flaps with large skin paddles. Read More

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November 2018
1 Read

An atypical case of pulmonary embolism from a jugular vein.

Echo Res Pract 2018 Dec;5(4):K67-K72

University of Medicine and Pharmacy, Carol Davila, Bucharest, Romania.

Neck venous malformations and their potentially life-threatening complications are rarely reported in the available literature. Cases of aneurysmal or hypo-plastic jugular vein thrombosis associated with systemic embolization have not been frequently reported. We present the case of a 60-year-old male, without any known risk factors for thromboembolic disease, admitted for sudden onset dyspnea. Read More

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December 2018
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Population Health Management: Coming of Age.

Authors:
Karen Zander

Prof Case Manag 2019 Jan/Feb;24(1):26-38

Karen Zander, MS, RN, CMAC, FAAN, is President and CEO of The Center for Case Management. Her pioneering work with clinical case management and CareMap systems, begun at New England Medical Center Hospitals (Now Tufts Medical Center) in Boston more than 30 years ago, is internationally recognized. Hospitals and Health Networks named her a "Cutting Edge" leader. She is the author of many articles about case management and editor of The New Definition newsletter. Ms Zander has also written several case management texts: (1) Competency Evaluation Tools for Case Management Professionals, (2) Emergency Department Case Management: The Compendium of Best Practices second edition with K. Walsh, and Hospital Case Management Models: Evidence Connecting the Bedside to the Boardroom and a second edition: Case Management Models: Best Practices for Health Systems and ACOs, also from HCPro. Ms Zander holds a BSN from Illinois Wesleyan University, an MS in Psychiatric-Mental Health Nursing from Boston University, postgraduate credits from Massachusetts Institute of Technology, and a Doctorate in Humane Letters (DHL), honoris causa, from Illinois, Wesleyan University. She has been on the Partners Care at Home Patient/Family Advisory Board for 3 years, and has been a cellist in the New Philharmonia Orchestra for over 25 years.

Purpose: Population health is finally catching up with itself. Before it was known as disease management, it began at New England Medical Center in Boston, MA (now Tufts Medical Center), more than 30 years ago.

Implications For Case Management Practice: Take-away ideas: (1) population health management is about segmenting and targeting specific patient populations for interventions that are evidence based; (2) there are currently many examples of population health management; (3) population health management will not work without social workers and nurse navigators/care coordinators working side by side. Read More

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November 2018

Focused Ultrasound for Neuromodulation.

Authors:
David P Darrow

Neurotherapeutics 2018 Nov 28. Epub 2018 Nov 28.

Department of Neurosurgery, University of Minnesota, 420 Delaware St SE, MMC 96, Room D-429, Minneapolis, MN, 55455, USA.

For more than 70 years, the promise of noninvasive neuromodulation using focused ultrasound has been growing while diagnostic ultrasound established itself as a foundation of clinical imaging. Significant technical challenges have been overcome to allow transcranial focused ultrasound to deliver spatially restricted energy into the nervous system at a wide range of intensities. High-intensity focused ultrasound produces reliable permanent lesions within the brain, and low-intensity focused ultrasound has been reported to both excite and inhibit neural activity reversibly. Read More

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November 2018
2 Reads