261 results match your criteria Basic and clinical neuroscience[Journal]


Different Expressions of Specific Transcription Factors of Th1 () and Th2 cells () by Peripheral Blood Mononuclear Cells From Patients With Multiple Sclerosis.

Basic Clin Neurosci 2018 Nov-Dec;9(6):458-469. Epub 2018 Nov 1.

Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Introduction: Multiple Sclerosis (MS) is an inflammatory disorder caused by self-reactive Th1 lymphocytes, while Th2 cells may confer protection. The Th1 and Th2 cell differentiation are regulated by specific transcription factors, especially and , respectively. This investigation aimed to measure the and expression by Peripheral Blood Mononuclear Cells (PBMCs) obtained from MS patients after specific and non-specific in vitro stimulation. Read More

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http://dx.doi.org/10.32598/bcn.9.6.458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359686PMC
November 2018
1 Read

Cognitive Process in Patients With Obsessive-Compulsive Disorder: A Cross-Sectional Analytic Study.

Basic Clin Neurosci 2018 Nov-Dec;9(6):448-457. Epub 2018 Nov 1.

Behavioral Disorders and Substance Abuse Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: In recent studies, deficit in cognitive process has been investigated as one of the etiological hypotheses in a wide range of Obsessive-Compulsive Disorder (OCD). This research aimed to compare cognitive process in patients with OCD and healthy groups.

Methods: In the current cross-sectional analytic study, 43 patients with OCD and 43 healthy individuals matched with gender, age, educational and marital status were selected by convenience sampling method and assessed by Wisconsin Cart Sorting Test (WCST), Paced Auditory Serial Addition Test (PASAT) and Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Read More

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http://dx.doi.org/10.32598/bcn.9.6.448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359683PMC
November 2018
2 Reads

Early Posterior Negativity as Facial Emotion Recognition Index in Children With Attention Deficit Hyperactivity Disorder.

Basic Clin Neurosci 2018 Nov-Dec;9(6):439-447. Epub 2018 Nov 1.

Department of Speech Therapy, School of Rehabilitation, Babol University of Medical Sciences, Babol, Iran.

Introduction: Studies indicate that children with Attention Deficit Hyperactivity Disorder (ADHD) have deficits in social and emotional functions. It can be hypothesized that these children have some deficits in early stages of facial emotion discrimination. Based on this hypothesis, the present study investigated neural correlates of early visual processing during emotional face recognition in this group compared with typically developing children using the Event-Related Potentials (ERPs). Read More

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http://dx.doi.org/10.32598/bcn.9.6.439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359687PMC
November 2018
2 Reads

Genetic Variations of (rs947267 and rs3918342) and Genes (rs165599 and rs4680) in Schizophrenia and Bipolar I Disorder.

Basic Clin Neurosci 2018 Nov-Dec;9(6):429-438. Epub 2018 Nov 1.

Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Introduction: Genetic and environmental factors are involved in the incidence of schizophrenia and bipolar disorder. Many reports confirm that several common genes are connected with these two psychotic disorders. Several neurotransmitters may be involved in the molecular mechanisms of schizophrenia and bipolar disorder. Read More

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http://dx.doi.org/10.32598/bcn.9.6.429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359688PMC
November 2018
3 Reads

rCBV- and ADC-based Grading of Meningiomas With Glimpse Into Emerging Molecular Diagnostics.

Basic Clin Neurosci 2018 Nov-Dec;9(6):417-428. Epub 2018 Nov 1.

Department of Biotechnology & Molecular Medicine, Post Graduate Institute of Medical Sciences, Regional Cancer Centre, Sharma University of Health Sciences, Rohtak, Haryana, India.

Introduction: This study was conducted to grade meningiomas based on relative Cerebral Blood Volume (rCBV) and Apparent Diffusion Coefficient (ADC) to help surgeons plan the approach and extent of operation as well as decide on the need of any adjuvant radio/chemo therapy. The current and evolving genomic, proteomic, and spectroscopic technologies are also discussed which can supplement the current radiologic methods and procedures in grading meningiomas.

Methods: A total of 35 patients with meningioma prospectively underwent basic MR sequences (T1W, T2W, T2W/FLAIR) in axial, sagittal and coronal planes followed by Diffusion Weighted (DW) imaging having b value of 1000 (minimum ADC values used for analysis). Read More

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http://dx.doi.org/10.32598/bcn.9.6.417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359681PMC
November 2018
1 Read

Effect of Co-administration of Bumetanide and Phenobarbital on Seizure Attacks in Temporal Lobe Epilepsy.

Basic Clin Neurosci 2018 Nov-Dec;9(6):408-416. Epub 2018 Nov 1.

Department of Tissue Engineering & Regenerative Medicine, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: The resistance of temporal lobe epilepsy to classic drugs is thought to be due to disruption in the excitation/inhibition of this pathway. Two chloride transporters, NKCC1 and KCC2, are expressed differently for the excitatory state of Gamma-Amino Butyric Acid (GABA). The present study explored the effect of bumetanide as a selective NKCC1 inhibitor either alone or in combination with the phenobarbital in the pilocarpine model of epilepsy. Read More

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http://bcn.iums.ac.ir/article-1-826-en.html
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http://dx.doi.org/10.32598/bcn.9.6.408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359685PMC
November 2018
11 Reads

Sleep Architecture and Hypothalamic-Pituitary-Adrenal Activity in Paradoxical and Psychophysiological Insomnia.

Basic Clin Neurosci 2018 Nov-Dec;9(6):397-407. Epub 2018 Nov 1.

Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Introduction: There are controversial reports about association between sleep and Hypothalamic-Pituitary-Adrenal (HPA) activity. Studies have reported the influence of insomnia on HPA hormones. However, they usually ignored the heterogeneity of insomnia symptoms, so subtypes of the disorder have not been considered in the reports. Read More

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http://dx.doi.org/10.32598/bcn.9.6.397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359682PMC
November 2018
5 Reads

Effects of Jobelyn on Isoniazid-Induced Seizures, Biomarkers of Oxidative Stress and Glutamate Decarboxylase Activity in Mice.

Basic Clin Neurosci 2018 Nov-Dec;9(6):389-396. Epub 2018 Nov 3.

Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Introduction: Isoniazid-induced seizure, often described as Status Epilepticus (SE), is an emergency condition characterized by repeated convulsive episodes that responds poorly to the currently available anticonvulsant drugs. The current study aimed at ascertaining the effect of Jobelyn (JB), an African dietary supplement, on seizures, altered oxidative stress, and glutamate decarboxylase activity induced by isoniazid in mice.

Methods: A total of 6 mice received JB (10-50 mg/kg, PO), pyridoxine (300 mg/kg), diazepam (5 mg/kg), or distilled water (10 mL/kg) 30 minutes prior to the induction of SE with injection of isoniazid (300 mg/kg, IP). Read More

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http://dx.doi.org/10.32598/bcn.9.6.389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359684PMC
November 2018
3 Reads

Recent Advances in Hybrid Brain-Computer Interface Systems: A Technological and Quantitative Review.

Basic Clin Neurosci 2018 Sep-Oct;9(5):373-388. Epub 2018 Sep 1.

Department of Biomedical Engineering, Faculty of New Sciences and Technologies, Semnan University, Semnan, Iran.

Brain-Computer Interface (BCI) is a system that enables users to transmit commands to the computer using their brain activity recorded by electroencephalography. In a Hybrid Brain-Computer Interface (HBCI), a BCI control signal combines with one or more BCI control signals or with Human-Machine Interface (HMI) biosignals to increase classification accuracy, boost system speed, and improve user's satisfaction. HBCI systems are categorized according to the type of combined signals and the combination technique (simultaneous or sequential). Read More

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http://dx.doi.org/10.32598/bcn.9.5.373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360492PMC
September 2018

The Effect of Parental Medical History on the Prevalence of Cerebrovascular Diseases in Their Children in an Iranian Population.

Basic Clin Neurosci 2018 Sep-Oct;9(5):367-372. Epub 2018 Sep 1.

Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran.

Introduction: Still a controversial issue, family history is known as a risk factor for the development of Cerebrovascular Diseases (CVD). In this study, we aimed to evaluate the relationship between parental history and risk of CVD in their offspring in Iranian population.

Methods: Isfahan Cohort Study (ICS) included total 6504 healthy participants which were randomly selected through a two-stage cluster sampling method from three districts. Read More

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http://dx.doi.org/10.32598/bcn.9.5.367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360496PMC
September 2018
1 Read

Chemical Composition and Role of Opioidergic System in Antinociceptive Effect of Essential Oil.

Basic Clin Neurosci 2018 Sep-Oct;9(5):357-366. Epub 2018 Sep 1.

Department of Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.

Introduction: has been used widely for various therapeutic purposes in Iranian folk medicine. The current study aimed to determine interaction of antinociceptive effect of the Essential Oil of (EOZC) and opioidergic system in male rats using formalin test.

Methods: Sixty-four male Wistar rats were divided into eight groups. Read More

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http://bcn.iums.ac.ir/article-1-1066-en.html
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http://dx.doi.org/10.32598/bcn.9.5.357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360493PMC
September 2018
7 Reads

Erythropoietin Pretreatment Effect on Blood Glucose and Its Relationship With Inflammatory Factors After Brain Ischemic-Reperfusion Injury in Rats.

Basic Clin Neurosci 2018 Sep-Oct;9(5):347-356. Epub 2018 Sep 1.

Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Introduction: Brain Ichemic-Reperfusion Injury (IRI) activates different pathophysiological processes. It also changes physiological parameters such as Blood Glucose (BG) level. An increase in BG after stroke is associated with poor clinical outcomes. Read More

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http://dx.doi.org/10.32598/bcn.9.5.347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360489PMC
September 2018
1 Read

Serum Proteomic Study of Women With Obsessive-Compulsive Disorder, Washing Subtype.

Basic Clin Neurosci 2018 Sep-Oct;9(5):337-346. Epub 2018 Sep 1.

Department of Psychosomatic, Taleghani Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Many genetic studies are conducted on Obsessive-Compulsive Disorder (OCD). however, a high-throughput examination of proteome profile of this severe disease has not been performed yet.

Methods: Here, the proteomic study of OCD patients' serum samples was conducted by the application of Two-Dimensional Electrophoresis (2DE) followed by Mass Spectrometry (MALDI-TOF-TOF). Read More

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http://dx.doi.org/10.32598/bcn.9.5.337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360490PMC
September 2018
2 Reads

The Effect of Orally Administered Probiotics on the Behavioral, Cellular, and Molecular Aspects of Adjuvant-Induced Arthritis.

Basic Clin Neurosci 2018 Sep-Oct;9(5):325-336. Epub 2018 Sep 1.

Neurophysiology Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Rheumatoid Arthritis (RA) is a chronic autoimmune disease, which is accompanied with pain, hyperalgesia, and edema. Overproduction of pro-inflammatory cytokines and activation of intracellular signaling pathways sustain the RA symptoms considerably. There is a strong correlation between the expression of cytokines and opioid receptors in the arthritis process. Read More

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http://bcn.iums.ac.ir/article-1-977-en.html
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http://dx.doi.org/10.32598/bcn.9.5.325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360491PMC
September 2018
7 Reads

Neuroprotective Effect of Quercetin Nanocrystal in a 6-Hydroxydopamine Model of Parkinson Disease: Biochemical and Behavioral Evidence.

Basic Clin Neurosci 2018 Sep-Oct;9(5):317-324. Epub 2018 Sep 1.

Department of Medicinal Plants, School of Science and Herbs, Amol University of Special Modern Technologies, Amol, Iran.

Introduction: Studies have suggested that free radicals-induced neurodegeneration is one of the many studies of Parkinson Disease (PD). Quercetin as a natural polyphenol has been regarded as a significant player in altering the progression of neurodegenerative diseases by protecting from damages caused by free radicals. Owing to its poor water solubility, preparation of its oral formulation is urgently needed. Read More

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http://dx.doi.org/10.32598/bcn.9.5.317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360495PMC
September 2018
1 Read

Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation.

Basic Clin Neurosci 2018 Sep-Oct;9(5):307-316. Epub 2018 Sep 1.

Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Sleep deprivation is a common complaint in modern societies. Insufficient sleep has increased the risk of catching neurodegenerative diseases such as Alzheimer's. Several studies have indicated that restricted sleep increases the level of deposition of β-amyloid and formation of neurofibrillary tangles, the major brain microstructural hallmarks for Alzheimer disease. Read More

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http://dx.doi.org/10.32598/bcn.9.5.307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360494PMC
September 2018
2 Reads

The Conference of the Birds: An Old Artistic Concept Making Sense in Modern Sciences.

Basic Clin Neurosci 2018 Jul-Aug;9(4):297-305. Epub 2018 Jul 1.

Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

In this article, we will discuss scientific aspects of an old Persian story, Simorgh, in the book of . The story is fulfilled with artistic and philosophical metaphors that make sense in two hot topics of the contemporary modern sciences i.e. Read More

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http://bcn.iums.ac.ir/article-1-843-en.html
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http://dx.doi.org/10.32598/bcn.9.4.297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276536PMC
July 2018
14 Reads

Effects of Clavulanic Acid on the Acquisition and Reinstatement Following Morphine-induced Conditioned Place Preference in Mice.

Basic Clin Neurosci 2018 Jul-Aug;9(4):289-296. Epub 2018 Jul 1.

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: β-Lactam antibiotics like Clavulanic Acid (CA) enhances cellular glutamate uptake through activation of Glutamate Transporter subtype 1 (GLT-1) and decreases the level of glutamate in the nervous system. Based on studies, blocking the glutamate activity inhibits morphine-induced Conditioned Place Preference (CPP) in animals. Therefore, the effects of CA on the acquisition of morphine craving were evaluated using the CPP model in the current study. Read More

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http://dx.doi.org/10.32598/bcn.9.4.289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276532PMC

Assessing the Effects of Opioids on Pathological Memory by a Computational Model.

Basic Clin Neurosci 2018 Jul-Aug;9(4):275-288. Epub 2018 Jul 1.

Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Opioids hijack learning and memory formation mechanisms of brain and induce a pathological memory in the hippocampus. This effect is mainly mediated by modifications in glutamatergic system. Speaking more precisely, Opioids presence in a synapse inhibits blockage of N-Methyl-D-Aspartate Receptor (NMDAR) by Mg, enhances conductance of NMDAR and thus, induces false Long-Term Potentiation (LTP). Read More

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http://bcn.iums.ac.ir/article-1-962-en.html
Publisher Site
http://dx.doi.org/10.32598/bcn.9.4.275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276537PMC
July 2018
12 Reads

Comparison of Effects of Light Anesthetics, Diethyl Ether and Carbon Dioxide, on Hypothalamic Paraventricular Nucleus D and D Dopamine Receptors- and Glucosensitive Neurons-Induced Food Intake in Fasted Conscious Rats.

Basic Clin Neurosci 2018 Jul-Aug;9(4):269-274. Epub 2018 Jul 1.

Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Carbon Dioxide (CO) and diethyl ether are used as light anesthetics. However, experimental data about their side effects are scarce. In addition, in all our previous works on regulatory mechanisms of hypothalamus during food intake, including the effect of Paraventricular Nucleus (PVN) D and D dopamine receptors and glucosensitive neurons, the drug injections were performed under brief diethyl ether anesthesia. Read More

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http://dx.doi.org/10.32598/bcn.9.4.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276533PMC
July 2018
3 Reads

Assessment of Behavioral Approach and Behavioral Inhibition Systems in Mood Disorders.

Basic Clin Neurosci 2018 Jul-Aug;9(4):261-268. Epub 2018 Jul 1.

Department of Psychiatry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Psychiatric disorders could be evaluated in terms of behavioral activation and inhibition systems. Dysregulation of these systems may lead to development of manic or depressive episodes in patients with mood disorders. This study aimed to identify Behavioral Approach System (BAS) and Behavioral Inhibition System (BIS) hypersensitivity as the functional brain system behaviors in patients with major depressive disorder and bipolar mood disorder I, compared to healthy individuals. Read More

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http://bcn.iums.ac.ir/article-1-858-en.html
Publisher Site
http://dx.doi.org/10.32598/bcn.9.4.261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276539PMC
July 2018
23 Reads

The Antinociceptive Effects of Rosuvastatin in Chronic Constriction Injury Model of Male Rats.

Basic Clin Neurosci 2018 Jul-Aug;9(4):251-260. Epub 2018 Jul 1.

Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

Introduction: According to studies, statins possess analgesics and anti-inflammatory properties. In the present study, we examined the antinociceptive, anti-inflammatory and antioxidative effects of rosuvastatin in an experimental model of Chronic Constriction Injury (CCI).

Methods: Our study was conducted on four groups; sham, CCI (the control group), CCI+rosuvastatin (i. Read More

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http://dx.doi.org/10.32598/bcn.9.4.251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276538PMC
July 2018
4 Reads

Environmental Enrichment Attenuates Morphine-Induced Conditioned Place Preference and Locomotor Sensitization in Maternally Separated Rat Pups.

Basic Clin Neurosci 2018 Jul-Aug;9(4):241-250. Epub 2018 Jul 1.

Laboratory of Animal Addiction Models, Physiology Research Center, Semnan University of Medical Sciences, Semnan, Iran.

Introduction: This study investigated the effect of the environmental enrichment during adolescence on morphine-induced Conditioned Place Preference (CPP) and locomotor sensitization in maternally separated male and female rat pups.

Methods: Male Wistar rats were allowed to mate with female virgin Wistar rats. Pups were separated from them 3 hours per day during 2-14 days postnatal. Read More

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http://dx.doi.org/10.32598/bcn.9.4.241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276535PMC
July 2018
1 Read

Automatic Seizure Detection Based on Nonlinear Dynamical Analysis of EEG Signals and Mutual Information.

Basic Clin Neurosci 2018 Jul-Aug;9(4):227-240. Epub 2018 Jul 1.

Department of Bioelectrical Engineering, School of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran.

Introduction: In this paper, nonlinear dynamical analysis based on Recurrence Quantification Analysis (RQA) is employed to characterize the nonlinear EEG dynamics. RQA can provide useful quantitative information on the regular, chaotic, or stochastic property of the underlying dynamics.

Methods: We use the RQA-based measures as the quantitative features of the nonlinear EEG dynamics. Read More

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http://dx.doi.org/10.32598/bcn.9.4.227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276534PMC
July 2018
2 Reads

Neural Monitoring With CMOS Image Sensors.

Basic Clin Neurosci 2018 May-Jun;9(3):227-235

Department of Electrical Engineering, School of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran.

Implantable image sensors have several biomedical applications due to their miniature size, light weight, and low power consumption achieved through sub-micron standard CMOS (Complementary Metal Oxide Semiconductor) technologies. The main applications are in specific cell labeling, neural activity detection, and biomedical imaging. In this paper the recent research studies on implantable CMOS image sensors for neural activity monitoring of brain are being quantified and reviewed. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.3.227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037429PMC
July 2018
2 Reads

A Cognitive Neurodynamic Approach to Prediction of Students' Adaptation to College: An Ex-Post Facto Study.

Basic Clin Neurosci 2018 May-Jun;9(3):217-226

Health Matters First of Florida, Inc., Oakland, Florida, United States.

Introduction: Campus life tends to make social and academic demands on college students. To cope with these demands, students are required to use their neurocognitive skills of problem-solving and planning intentional actions that target towards adaptation to college. This paper presents an illuminating perspective that would inform understanding of a new approach to cognitive neuroscience. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.3.217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037428PMC

The Effects of Iron Oxide Nanoparticles Administration on Depression Symptoms Induced by LPS in Male Wistar Rats.

Basic Clin Neurosci 2018 May-Jun;9(3):209-216

Department of Biology, Faculty of Sciences, Payame Noor University, Tehran, Iran.

Introduction: Depression is a mood disorder in which feelings of sadness, loss, anger, or frustration interfere with everyday life for one to several weeks. Several studies have shown that iron nanoparticles have neuroprotective and anti-inflammatory effects. This study aimed to evaluate anti-depressive effect of iron nanoparticles in male rats. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.3.209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037433PMC
July 2018
1 Read

Protective Effects of Morin Hydrate on Acute Stress-Induced Behavioral and Biochemical Alterations in Mice.

Basic Clin Neurosci 2018 May-Jun;9(3):195-208

Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Introduction: As stress affects the brain both physiologically and chemically, researchers try to find novel anti-stress compounds with beneficial therapeutic effects. In this regard, the effect of stress and its modulation by Morin hydrate was studied using different acute models in mice.

Methods: The models employed were anoxic tolerance, swimming endurance, and acute restraint test. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.3.195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037426PMC

Introducing Transthyretin as a Differentially Expressed Protein in Washing Subtype of Obsessive-Compulsive Disorder.

Basic Clin Neurosci 2018 May-Jun;9(3):187-194

Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Obsessive-Compulsive Disorder (OCD) as one of the important mental problems is valuable topic for proteomic research studies to better understand the underlying mechanisms of this disorder.

Methods: In this paper, gel-based proteomic was used to investigate the proteome profile of 16 female patients with OCD, washing subtype before and after treatment with fluoxetine and comparing them with 20 healthy female controls.

Results: One of the abnormally expressed protein spots in this study was introduced and examined for protein-protein interaction network analysis via Cytoscape and its plug-ins. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.3.187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037430PMC
July 2018
2 Reads

The Beneficial or Harmful Effects of Computer Game Stress on Cognitive Functions of Players.

Basic Clin Neurosci 2018 May-Jun;9(3):177-186

Department of Statistics, Faculty of Mathematical Sciences, Alzahra University, Tehran, Iran.

Introduction: Video games are common cultural issues with great influence in all societies. One of the important cognitive effects of video games is on creating stress on video players. The present research objective was to study different types of stress in players based on video game styles. Read More

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http://dx.doi.org/10.29252/nirp.bcn.9.3.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037427PMC
July 2018
2 Reads

Effects of the Extremely Low Frequency Electromagnetic Fields on NMDA-Receptor Gene Expression and Visual Working Memory in Male Rhesus Macaques.

Basic Clin Neurosci 2018 May-Jun;9(3):167-176

Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.

Introduction: The present research aimed to examine Visual Working Memory (VWM) test scores, as well as hormonal, genomic, and brain anatomic changes in the male rhesus macaques exposed to Extremely Low Frequency Magnetic Field (ELF-MF).

Methods: Four monkeys were exposed to two different ELF-MF frequencies: 1 Hz (control) and 12 Hz (experiment) with 0.7 μT (magnitude) 4 h/d for 30 consecutive days. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.3.167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037432PMC
July 2018
19 Reads

Effects of Acute and Chronic Restraint Stress on Reinstatement of Extinguished Methamphetamine-induced Conditioned Place Preference in Rats.

Basic Clin Neurosci 2018 May-Jun;9(3):157-166

Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: Methamphetamine (METH) is a neurotoxic psychostimulant with highly addictive potential that leads to compulsive drug use and vulnerability to relapse. Environmental cues, such as drug exposure, peer influence, and social stress, are the powerful triggers of drug relapse. In this study, we tried to find out the effect of acute and chronic restraint stress on reinstatement of extinguished METH-induced Conditioned Place Preference (CPP) in rats. Read More

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http://dx.doi.org/10.29252/nirp.bcn.9.3.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037431PMC

Sleep Architecture in Patients With Primary Snoring and Obstructive Sleep Apnea.

Basic Clin Neurosci 2018 Mar-Apr;9(2):147-156

Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Introduction: This study aimed to investigate sleep architecture in patients with primary snoring and obstructive sleep apnea.

Methods: In this study, we analyzed polysomnographic data of 391 clients who referred to Sleep Disorders Research Center (SDRS). These people were classified into three groups based on their Apnea-Hypopnea Index (AHI) and snoring; control, Primary Snoring (PS), and Obstructive Sleep Apnea (OSA) group. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.2.147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026090PMC
July 2018
18 Reads

Normal Electrical Activity of the Brain in Obsessive-Compulsive Patients After Anodal Stimulation of the Left Dorsolateral Prefrontal Cortex.

Basic Clin Neurosci 2018 Mar-Apr;9(2):135-146

Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Transcranial Direct Current Stimulation (tDCS) has been used as a non-invasive method to increase the plasticity of brain. Growing evidence has shown several brain disorders such as depression, anxiety disorders, and chronic pain syndrome are improved following tDCS. In patients with Obsessive-Compulsive Disorder (OCD), increased brain rhythm activity particularly in the frontal lobe has been reported in several studies using Eectroencephalogram (EEG). Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.2.135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026096PMC
July 2018
14 Reads

Genes Encoding GABA-β and HT1D Receptors in Bipolar I (Manic Phase) Patients.

Basic Clin Neurosci 2018 Mar-Apr;9(2):129-134

Behavioral Disorders and Substance Abuse Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: According to the cumulative evidence, genes encoding GABA receptors inhibit neurotransmitters in CNS and are intricately involved in the pathogenesis of mood disorders. Based on this hypothesis, these genes may be expressed in bipolar patients. As a result, we evaluated the gene expressions of GABA-β3 and HT1D receptors to assess their associations with bipolar mood disorder. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.2.129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026092PMC
July 2018
3 Reads

Management of Pituitary Adenomas: Mononostril Endoscopic Transsphenoidal Surgery.

Basic Clin Neurosci 2018 Mar-Apr;9(2):121-128

Department of Surgery, Division of Neurosurgery, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Introduction: The endoscopic transsphenoidal approach for pituitary adenomas and other sellar lesions is quickly becoming the procedure of choice in their surgical management. The most common approach is binostril three-hand technique which requires a large exposure and subjects both nasal cavities to potential trauma. To reduce nasal morbidity, we employ a mononostril two-hand technique with the help of the endoscope holder. Read More

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http://dx.doi.org/10.29252/nirp.bcn.9.2.121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026095PMC
July 2018
8 Reads

Stress and Perception of Emotional Stimuli: Long-term Stress Rewiring the Brain.

Basic Clin Neurosci 2018 Mar-Apr;9(2):107-120

Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran.

Introduction: Long-term stressful situations can drastically influence one's mental life. However, the effect of mental stress on recognition of emotional stimuli needs to be explored. In this study, recognition of emotional stimuli in a stressful situation was investigated. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.2.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026093PMC
July 2018
17 Reads

Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran.

Basic Clin Neurosci 2018 Mar-Apr;9(2):101-106

Cellular and Molecular Research Center, Department of Anatomy, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence. In humans, A118G Single Nucleotide Polymorphisms (SNP) on μ-Opioid Receptor (MOR), 36 G>T in κ-Opioid Receptor (KOR), and T921C in the δ-Opioid Receptor (DOR) have been found to associate with substance dependence. Read More

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http://dx.doi.org/10.29252/nirp.bcn.9.2.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026094PMC
July 2018
1 Read

The Neuroprotective Effects of Long-Term Repetitive Transcranial Magnetic Stimulation on the Cortical Spreading Depression-induced Damages in Rat's Brain.

Basic Clin Neurosci 2018 Mar-Apr;9(2):87-100

Department of Radiology, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran.

Introduction: Cortical Spreading Depression (CSD) is a propagating wave of neural and glial cell depolarization with important role in several clinical disorders. Repetitive Transcranial Magnetic Stimulation (rTMS) is a potential tool with preventive treatment effects in psychiatric and neuronal disorders. In this paper, we study the effects of rTMS on CSD by using behavioral and histological approaches in hippocampus and cortical regions. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.2.87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026089PMC

Diagnosis of Meningitis Caused by Pathogenic Microorganisms Using Magnetic Resonance Imaging: A Systematic Review.

Basic Clin Neurosci 2018 Mar-Apr;9(2):73-86

Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Introduction: Bacterial meningitis is an acute infectious inflammation of the protective membranes covering the brain. Its early diagnosis is vital because of its high morbidity and mortality. It is mostly diagnosed by a gold standard diagnostic tool i. Read More

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http://dx.doi.org/10.29252/nirp.bcn.9.2.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026091PMC
July 2018
14 Reads

Comparison Between Three-Dimensional Diffusion-Weighted PSIF Technique and Routine Imaging Sequences in Evaluation of Peripheral Nerves in Healthy People.

Basic Clin Neurosci 2018 Jan-Feb;9(1):65-71

Department of Physical Education, School of Education & Psychology, Shiraz University, Shiraz, Iran.

Introduction: The present study aims to evaluate the Three-Dimensional Diffusion-Weighted reversed fast imaging with steady state free precession (3D DW-PSIF) sequence with respect to imaging of the peripheral nerves; the tibial, medial, and lateral plantar nerves in the lower extremity, ulnar and median nerve in the upper extremity, sciatic nerve, brachial plexus, and lumbosacral plexus, and also to compare its usefulness with the current two-dimensional sequences on a 1.5 T MR scanner.

Methods: A total of 25 healthy subjects underwent MR imaging of peripheral nerves, 5 subjects in each area. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.1.65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015634PMC
June 2018
4 Reads

The Relationship Between Salivary Alpha Amylase Activity and Score of McGill Pain Questionnaire in Patients With Tension Type Headache.

Basic Clin Neurosci 2018 Jan-Feb;9(1):59-64

Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.

Introduction: Tension-type headache is the most common type of headache across the world. Saliva as a non-invasive medium is used to detect a wide range of diseases. Salivary Alpha-Amylase (SAA) levels has been suggested as a potential indirect marker for detecting Sympathoadrenal Medullary (SAM) activity, which is activated by pain. Read More

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http://dx.doi.org/10.29252/nirp.bcn.9.1.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015635PMC
June 2018
1 Read

Low Frequency Stimulation Reverses the Kindling-Induced Impairment of Learning and Memory in the Rat Passive-avoidance Test.

Basic Clin Neurosci 2018 Jan-Feb;9(1):51-58

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Introduction: The life quality of patients with epileptic seizures is highly affected by cognitive deficits. Low Frequency Stimulation (LFS) is a novel approach for the treatment of pharmacoresistant epilepsy. The main goal of this research is investigating the possible effect of LFS on seizure-induced cognitive dysfunction. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.1.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015633PMC
June 2018
12 Reads

Discordant Relationship Between Evaluation of Facial Expression and Subjective Pain Rating Due to the Low Pain Magnitude.

Basic Clin Neurosci 2018 Jan-Feb;9(1):43-50

Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan.

Introduction: Facial expression to pain is an important pain indicator; however, facial movements look unresponsive when perceiving mild pain. The present study investigates whether pain magnitude modulates the relationship between subjective pain rating and an observer's evaluation of facial expression.

Methods: Twelve healthy volunteers were recruited to obtain 108 samples for pain rating with Visual Analogue Scale (VAS). Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.1.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015640PMC
June 2018
17 Reads

Development, Cross-Cultural Adaptation, and Psychometric Characteristics of the Persian Progressive Aphasia Language Scale in Patients With Primary Progressive Aphasia: A Pilot Study.

Basic Clin Neurosci 2018 Jan-Feb;9(1):35-42

Memory and Behavioral Neurology Division, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Primary Progressive Aphasia (PPA) is a neurological condition characterized by progressive dissolution of language capabilities. The Progressive Aphasia Language Scale (PALS) is an easy-to-apply bedside clinical scale capable of capturing and grading the key language features essential for the classification of PPA. The objective of the present study was to develop and validate the Persian version of the PALS (PALS-P) as a clinical language assessment test. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.1.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015637PMC
June 2018
10 Reads

Stereological Method for Assessing the Effect of Vitamin C Administration on the Reduction of Acrylamide-induced Neurotoxicity.

Basic Clin Neurosci 2018 Jan-Feb;9(1):27-34

Department of Anatomy and Cell Biology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.

Introduction: Acrylamide (ACR) consumption is increasing all over the world. There are some evidence on the literature about its neurotoxic effect on mature animals, but the effects of ACR on postnatal development have been less studied. The purpose of this study was to evaluate the effects of ACR on development of cortical layer, white matter, and number of Purkinje cells of the cerebellum in rat newborns. Read More

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http://dx.doi.org/10.29252/nirp.bcn.9.1.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015636PMC
June 2018
1 Read

Generating the Visual Biofeedback Signals Applicable to Reduction of Wrist Spasticity: A Pilot Study on Stroke Patients.

Basic Clin Neurosci 2018 Jan-Feb;9(1):15-26

Department of Physiotherapy, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Application of biofeedback techniques in rehabilitation has turned into an exciting research area during the recent decade. Providing an appropriate visual or auditory biofeedback signal is the most critical requirement of a biofeedback technique. In this regard, changes in Surface Electromyography (SEMG) signals during wrist movement can be used to generate an indictable visual biofeedback signal for wrist movement rehabilitation via SEMG biofeedback. Read More

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http://dx.doi.org/10.29252/nirp.bcn.9.1.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015639PMC
June 2018
4 Reads

Comparison of Memory Impairment and Oxidative Stress Following Single or Repeated Doses Administration of Scopolamine in Rat Hippocampus.

Basic Clin Neurosci 2018 Jan-Feb;9(1):5-14

Department of Toxicology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Introduction: Scopolamine, a muscarinic cholinergic receptor antagonist, is widely used to induce memory impairment in experimental animals. The present study aims to compare memory impairment and oxidative stress following single and repeated doses administration of scopolamine.

Methods: A group of rats received a single shot of scopolamine in different doses (0. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.9.1.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015638PMC
June 2018
17 Reads

Commentary on "Co-Occurrence of Pituitary Adenoma With Suprasellar and Olfactory Groove Meningiomas".

Basic Clin Neurosci 2017 Nov-Dec;8(6):513-515

Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Messina, Messina, Italy.

Recently, published an article by Lim et al. (2016) entitled . They claimed it as the first case of co-occurence of these two malignancies. Read More

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http://bcn.iums.ac.ir/article-1-900-en.html
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http://dx.doi.org/10.29252/NIRP.BCN.8.6.513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010656PMC
June 2018
5 Reads

In Vivo Psychopharmacological Investigation of and Extracts on Wistar Rats.

Basic Clin Neurosci 2017 Nov-Dec;8(6):503-512

Department of Pharmacology and Clinical Research, School of Pharmaceutical Sciences, IFTM University, Moradabad, India.

Introduction: In our modern era, life style of human being changes and updates every day that may affect their health status. There is an incredible expectation that natural origin drugs lack undesirable effects not like synthetic drugs, though have the same potency and efficacy. No scientific data is available about the antianxiety properties of root and leaves. Read More

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http://dx.doi.org/10.29252/NIRP.BCN.8.6.503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010653PMC