332 results match your criteria Basic and clinical neuroscience[Journal]


A Simulation Model of Neural Activity During Hand Reaching Movement.

Basic Clin Neurosci 2020 Jan-Feb;11(1):121-128. Epub 2020 Jan 1.

Neuroscience & Neuroengineering Research Lab., Department of Biomedical Engineering, School of Electrical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran.

Introduction: The neural response is a noisy random process. The neural response to a sensory stimulus is completely equivalent to a list of spike times in the spike train. In previous studies, decreased neuronal response variability was observed in the cortex's various areas during motor preparatory in reaching tasks. Read More

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http://dx.doi.org/10.32598/bcn.9.10.390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253821PMC
January 2020

Cognitive-Behavioral Therapy Versus Transcranial Direct Current Stimulation for Augmenting Selective Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder Patients.

Basic Clin Neurosci 2020 Jan-Feb;11(1):111-120. Epub 2020 Jan 1.

Department of Psychology, Zanjan University of Medical Sciences, Zanjan, Iran.

Introduction: Obsessive-Compulsive Disorder (OCD) belongs to the categories of psychiatric disorders with the potential to turn into a chronic condition without receiving the necessary treatments. The main feature of OCD is the frequent or intense obsession and compulsion that might induce great pain and suffering in patients. Moreover, as one of the most prevalent abnormalities, depression usually follows OCD. Read More

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http://dx.doi.org/10.32598/bcn.11.1.13333.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253812PMC
January 2020

Comparing the Effectiveness of Computer-Based, Manual-based, and Combined Cognitive Rehabilitation on Cognitive Functions in Relapsing-Remitting Multiple Sclerosis Patients.

Basic Clin Neurosci 2020 Jan-Feb;11(1):99-110. Epub 2020 Jan 1.

Department of Clinical Psychology, Arak University of Medical Sciences, Arak, Iran.

Introduction: This study aimed to compare the effectiveness of computer-based, manual-based, and combined cognitive rehabilitation to improve cognitive functions among patients with Relapsing-Remitting Multiple Sclerosis (RRMS).

Methods: This was a quasi-experimental study with a pre-test-post-test, and a 2-month follow-up, as well as a control group design. Sixty female patients with RRMS were selected by convenience sampling technique. Read More

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http://dx.doi.org/10.32598/bcn.9.10.430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253816PMC
January 2020

Evaluating the Antidepressant Effect of Verbena officinalis L. (Vervain) Aqueous Extract in Adult Rats.

Basic Clin Neurosci 2020 Jan-Feb;11(1):91-98. Epub 2020 Jan 1.

Laboratory of Natural BioResources, University of Hassiba Benbouali, Chlef, Algeria.

Introduction: The present study aimed to investigate the antidepressant effect of Verbena (V.) officinalis L. aqueous extract in adult female rats. Read More

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http://dx.doi.org/10.32598/bcn.11.1.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253814PMC
January 2020

Improving the Izhikevich Model Based on Rat Basolateral Amygdala and Hippocampus Neurons, and Recognizing Their Possible Firing Patterns.

Basic Clin Neurosci 2020 Jan-Feb;11(1):79-90. Epub 2020 Jan 1.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Identifying the potential firing patterns following different brain regions under normal and abnormal conditions increases our understanding of events at the level of neural interactions in the brain. Furthermore, it is important to be capable of modeling the potential neural activities to build precise artificial neural networks. The Izhikevich model is one of the simplest biologically-plausible models, i. Read More

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http://dx.doi.org/10.32598/bcn.9.10.435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253815PMC
January 2020

The Therapeutic Effect of Exercise on Anxiety and Bowel Oxidative Stress in the Maternal Separation Animal Model.

Basic Clin Neurosci 2020 Jan-Feb;11(1):69-78. Epub 2020 Jan 1.

Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

Introduction: According to evidence, Early-Life Stress (ELS), mood disorders, and medical comorbidities, i.e. Irritable Bowel Syndrome (IBS), are correlated; however, the direct contribution of ELS to IBS manifestations is less understood. Read More

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http://dx.doi.org/10.32598/bcn.9.10.450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253811PMC
January 2020

The Therapeutic Effects of Low-Frequency Electrical Stimulations Adjunct to Sodium Valproate on Seizure and Behaviors.

Basic Clin Neurosci 2020 Jan-Feb;11(1):59-68. Epub 2020 Jan 1.

Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Iran.

Introduction: Consuming antidepressant medications induce several problems leading to the need for alternative agents for emotional disturbances. Antidepressant medications increase the seizure risk; thus, alternative treatments, like Antiepileptic Drugs (AED), might be useful for patients with epilepsy comorbid with a psychiatric disorder. The present study evaluated the behavioral effects of sodium valproate, a none effective dose in seizure treatment [100 mg/kg; Intraperitoneal (IP)] along with the application of Low-Frequency Stimulations (LFS) during CA1 hippocampal kindling. Read More

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http://dx.doi.org/10.32598/bcn.9.10.280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253820PMC
January 2020

Haloperidol's Effect on the Expressions of TGFB, NT-3, and BDNF genes in Cultured Rat Microglia.

Basic Clin Neurosci 2020 Jan-Feb;11(1):49-58. Epub 2020 Jan 1.

Molecular Biology and Genetics Department, Bogazic University, Istanbul, Turkey.

Introduction: Microglia, small glial cells, i.e. mesodermal in origin and found in the brain and spinal cord, play a key role in the maintenance of neurons and immune defense. Read More

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http://dx.doi.org/10.32598/bcn.11.1.1272.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253822PMC
January 2020

The Effect of Rosmarinic Acid on Apoptosis and nNOS Immunoreactivity Following Intrahippocampal Kainic Acid Injections in Rats.

Basic Clin Neurosci 2020 Jan-Feb;11(1):41-48. Epub 2020 Jan 1.

Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Kainic Acid (KA) is an ionotropic glutamate receptor agonist. KA can induce neuronal overactivity and excitotoxicity. Rosmarinic Acid (RA) is a natural polyphenolic compound with antioxidant, anti-apoptotic, anti-neurodegenerative, and anti-inflammatory properties. Read More

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http://dx.doi.org/10.32598/bcn.9.10.340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253813PMC
January 2020

Evaluating Chondroitin Sulfate and Dermatan Sulfate Expression in Glial Scar to Determine Appropriate Intervention Time in Rats.

Basic Clin Neurosci 2020 Jan-Feb;11(1):31-40. Epub 2020 Jan 1.

Department of Anatomy, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

Introduction: The proteoglycans of the extracellular matrix increases in the glial scar during spinal cord injury and significantly affects the inhibition of axonal regeneration.

Methods: The results of injury therapies are limited due to the lack of identifying a timely therapeutic intervention. The present study aimed to investigate the glial scar Chondroitin Sulfate (CS) and Dermatan Sulfate (DS) levels at different post-injury times to determine the appropriate time for therapeutic intervention. Read More

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http://dx.doi.org/10.32598/bcn.9.10.405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253819PMC
January 2020

The Potential Role of Glycogen Synthase Kinase-3β in Neuropathy-Induced Apoptosis in Spinal Cord.

Basic Clin Neurosci 2020 Jan-Feb;11(1):15-30. Epub 2020 Jan 1.

Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Glycogen Synthase Kinase-3β (GSK-3β) participates in several signaling pathways and plays a crucial role in neurodegenerative diseases, inflammation, and neuropathic pain. The ratio of phosphorylated GSK-3β over total GSK-3β (p-GSK-3β/t-GSK-3β) is reduced following nerve injury. Apoptosis is a hallmark of many neuronal dysfunctions in the context of neuropathic pain. Read More

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http://dx.doi.org/10.32598/bcn.11.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253818PMC
January 2020

Human Gait Control Using Functional Electrical Stimulation Based on Controlling the Shank Dynamics.

Basic Clin Neurosci 2020 Jan-Feb;11(1):1-14. Epub 2020 Jan 1.

Research Center of Biomedical Engineering, Mashhad Branch, Islamic Azad University, Mashhad, Iran.

Introduction: Efficient gait control using Functional Electrical Stimulation (FES) is an open research problem. In this research, a new intermittent controller has been designed to control the human shank movement dynamics during gait.

Methods: In this approach, first, the three-dimensional phase space was constructed using the human shank movement data recorded from the healthy subjects. Read More

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http://dx.doi.org/10.32598/bcn.11.1.173.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253817PMC
January 2020

Comparing the Efficacy of Anodal, Cathodal, and Sham Transcranial Direct Current Stimulation on Brain-Derived Neurotrophic Factor and Psychological Symptoms in Opioid-Addicted Patients.

Basic Clin Neurosci 2019 Nov-Dec;10(6):641-650. Epub 2019 Nov 1.

Department of Physiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Introduction: Today, addiction to opioids is a serious problem all over the world. Unfortunately, the consumption of these drugs and the number of addicted people have drastically increased. This research aimed at comparing the efficacy of anodal, cathodal, and sham transcranial Direct Current Stimulation (tDCS) on the Brain-Derived Neurotrophic Factor (BDNF) and psychological symptoms in opioid-addicted patients. Read More

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http://dx.doi.org/10.32598/BCN.10.6.1710.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253809PMC
November 2019

Altered Neural Response Induced by Central-Fatigue in the Cortical Area During High-Intensity Interval Pedaling.

Basic Clin Neurosci 2019 Nov-Dec;10(6):631-639. Epub 2019 Nov 1.

Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Introduction: The central-governor model explains the mechanism of endurance exercise-induced central fatigue, but high-intensity exercise-induced central fatigue has not been investigated yet. This study aimed to research how central fatigue during high-intensity intermittent pedaling alters the neural response, which results in Electroencephalography (EEG) recordings.

Methods: We assessed neural response by measuring the alternation of brainwave spectral power during an intermittent high-intensity 60-minute exercise on an ergometer cycle. Read More

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http://dx.doi.org/10.32598/BCN.9.10.440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253810PMC
November 2019

Evaluation of the Anti-apoptotic and Anti-cytotoxic Effect of Epicatechin Gallate and Edaravone on SH-SY5Y Neuroblastoma Cells.

Basic Clin Neurosci 2019 Nov-Dec;10(6):619-630. Epub 2019 Nov 1.

Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Introduction: Parkinson disease (PD) is the second most common neurodegenerative disease affecting older individuals with signs of motor disability and cognitive impairment. Epicatechin (EC) and edaravone have neuroprotective effects most probably due to their antioxidant activity; however, a limited number of studies have considered their role in PD. This research aimed at investigating the neuroprotective effect of EC and edaravone in a neurotoxin-induced model of PD. Read More

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http://dx.doi.org/10.32598/bcn.9.10.1159.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253806PMC
November 2019

Trans-Differentiation of Human Dental Pulp Stem Cells Into Cholinergic-Like Neurons Via Nerve Growth Factor.

Basic Clin Neurosci 2019 Nov-Dec;10(6):609-617. Epub 2019 Nov 1.

ENT and Head & Neck Research Center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Cell therapy has been widely considered as a therapeutic approach for neurodegenerative diseases and nervous system damage. Cholinergic neurons as one of the most important neurons that play a significant role in controlling emotions, mobility, and autonomic systems. In this study, Human Dental Pulp Stem Cells (hDPSCs) were differentiated into the cholinergic neurons by β-mercaptoethanol in the preinduction phase and also by the nerve growth factor (NGF) in the induction phase. Read More

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http://dx.doi.org/10.32598/bcn.10.6.609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253808PMC
November 2019

Developing the Persian Version of Sensory Gating Inventory and Assessing Its Validity and Reliability.

Basic Clin Neurosci 2019 Nov-Dec;10(6):597-607. Epub 2019 Sep 1.

Head & Neck Research Center, Department of Ear, Nose, and Throat Diseases, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Sensory Gating Inventory (SGI) measures behavioral aspects of Sensory Gating (SG), which filters irrelevant sensory inputs into the higher cortex. It modifies sensitivity to sensory stimuli. Abnormal SG leads to overloading of information in the brain and its subsequent dysfunction. Read More

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http://dx.doi.org/10.32598/BCN.9.10.360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253804PMC
September 2019

Investigating the Role of Brain Lateralization and Gender in Paranormal Beliefs.

Basic Clin Neurosci 2019 Nov-Dec;10(6):589-595. Epub 2019 Nov 1.

Department Psychology, University of Science and Culture, Tehran, Iran.

Introduction: Brain lateralization is associated with human behavior. Therefore, this study aimed at investigating the effects of brain lateralization on the scores of paranormal beliefs.

Methods: The study population included 180 students of Sanandaj universities, Sanandaj City, Iran who were selected with convenience sampling method (100 left-brained males, 6 left-brained females, 56 both left- and right-brained males and 22 both left- and right-brained females). Read More

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http://dx.doi.org/10.32598/BCN.9.10.923.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253801PMC
November 2019

Comparing the Effectiveness of Neurofeedback and Transcranial Direct Current Stimulation on Sleep Quality of Patients With Migraine.

Basic Clin Neurosci 2019 Nov-Dec;10(6):579-588. Epub 2019 Nov 1.

Department of Physiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Introduction: Migraine is considered one of the most common primary headache disorders. Migraine attacks may occur due to a lack of sleep. Furthermore, sleep is regarded as one of the smoothing factors of migraine pain. Read More

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http://dx.doi.org/10.32598/BCN.10.6.651.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253802PMC
November 2019

Partial Improvement of Spatial Memory Damages by Bone Marrow Mesenchymal Stem Cells Transplantation Following Trimethyltin Chloride Administration in the Rat CA1.

Basic Clin Neurosci 2019 Nov-Dec;10(6):567-577. Epub 2019 Nov 1.

Cellular and Molecular Research Center, Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Trimethyltin Chloride (TMT) is a neurotoxin that can kill neurons in the nervous system and activate astrocytes. This neurotoxin mainly damages the hippocampal neurons. After TMT injection, behavioral changes such as aggression and hyperactivity have been reported in animals along with impaired spatial and learning memory. Read More

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http://dx.doi.org/10.32598/BCN.9.10.90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253807PMC
November 2019

Protective Role of Apigenin Against Aβ 25-35 Toxicity Via Inhibition of Mitochondrial Cytochrome c Release.

Basic Clin Neurosci 2019 Nov-Dec;10(6):557-566. Epub 2019 Nov 1.

Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Cognitive dysfunction is the most common problem of patients with Alzheimer Disease (AD). The pathological mechanism of cognitive impairment in AD may contribute to neuronal loss, synaptic dysfunction, and alteration in neurotransmitters receptors. Mitochondrial synapses dysfunction due to the accumulation of Amyloid Beta (Aβ) is one of the earliest pathological features of AD. Read More

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http://dx.doi.org/10.32598/BCN.9.10.385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253805PMC
November 2019

Protein Kinase Cɛ in the Platelet and Hippocampal Tissue as a Diagnostic Biological Marker in Alzheimer Disease.

Basic Clin Neurosci 2019 Nov-Dec;10(6):545-556. Epub 2019 Nov 1.

Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.

Introduction: Alzheimer Disease (AD) is a neurodegenerative disorder characterized by the progressive loss of memory and other cognitive functions. Protein Kinase Cɛ (PKCɛ) is an isoform that most effectively suppresses Amyloid Beta (Aβ) production and synaptic loss.

Methods: In this study, spatial learning and memory for treated rats were evaluated by the Morris water maze test. Read More

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http://dx.doi.org/10.32598/bcn.9.10.80.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253800PMC
November 2019

Is Mitochondria Biogenesis and Neuronal Loss Prevention in Rat Hippocampus Promoted by Apigenin?

Basic Clin Neurosci 2019 Nov-Dec;10(6):541-543

Department of Neuroscience, Biomedicine and Movement Sciences, Unit of Human Anatomy, University of Verona, Verona, Italy.

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http://dx.doi.org/10.32598/bcn.10.6.541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253803PMC

Curcumin Effects on Memory Impairment and Restoration of Irregular Neuronal Distribution in the Hippocampal CA1 Region After Global Cerebral Ischemia in Male Rats.

Basic Clin Neurosci 2019 Sep-Oct;10(5):527-539. Epub 2019 Sep 1.

Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Global Cerebral Ischemia (GCI) causes neuronal damage with subsequent neurological and cognitive impairments. Curcumin has anti-inflammatory, antioxidant, and neuroprotective properties, which makes it a potential candidate for improving GCI-induced impairments. This study aimed to investigate the effects of curcumin on the neurological and memory deficits, as well as spatial neuronal distribution in the Cornu Ammonis 1 region after GCI in rats. Read More

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http://dx.doi.org/10.32598/bcn.9.10.365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149957PMC
September 2019

Combined Effect of Noise and Smoking on the Cognitive Performance of Automotive Industry Workers.

Basic Clin Neurosci 2019 Sep-Oct;10(5):515-526. Epub 2019 Sep 1.

Department of Epidemiology and Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Noise is an environmental stressor and can cause or exacerbate mental disorders, and affect the individual performance in certain conditions. This study aimed to evaluate the combined effects of noise and smoking on the cognitive performance of the workers in the automotive industry.

Methods: This research is a descriptive-analytical study with a cross-sectional design conducted on 300 workers randomly assigned into two groups of noise-exposed and nonexposed. Read More

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http://dx.doi.org/10.32598/bcn.10.5.513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149955PMC
September 2019

Correlation Analysis of the Tinnitus Handicap Inventory and Distress Network in Chronic Tinnitus: An EEG Study.

Basic Clin Neurosci 2019 Sep-Oct;10(5):499-514. Epub 2019 Sep 1.

Department of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Tinnitus is a common disorder with a considerable amount of distress that affects the patient's daily life. No objective tools were approved for measuring tinnitus distress. It can be estimated only by subjective scales and questionnaires, albeit, the Electroencephalography (EEG) studies have reported some alterations regarding tinnitus distress network. Read More

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http://dx.doi.org/10.32598/bcn.9.10.215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149958PMC
September 2019

A 6-Step Approach to Gain Higher Quality Results From Organotypic Hippocampal Brain Slices in a Traumatic Brain Injury Model.

Basic Clin Neurosci 2019 Sep-Oct;10(5):485-496. Epub 2019 Sep 1.

Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany.

Introduction: Organotypic Hippocampal Brain Slices (OHBS) provide a better alternative to in vivo models to scrutinize Traumatic Brain Injury (TBI). We followed a well-established TBI protocol but noticed that several factors might influence the results in such a set-up. Here, we describe a structured approach to generate more comparable results and discuss why specific eligibility criteria should be applied. Read More

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http://dx.doi.org/10.32598/bcn.9.10.235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149959PMC
September 2019

Neuropsychological Decomposing Stroop Interference Into Different Cognitive Monitoring: An Exploratory Factor Analysis.

Authors:
Mazaher Rezaei

Basic Clin Neurosci 2019 Sep-Oct;10(5):475-483. Epub 2019 Sep 1.

Departments of Clinical Psychology, Shahid Beheshti Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.

Introduction: There are two alternative explanations of the Stroop phenomenon. Several studies have revealed that the difference in performance on congruent and incongruent trials can arise from response interference. On the contrary, many authors have claimed that Stroop interference might occur at earlier processing stages related to semantic or conceptual encoding. Read More

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http://dx.doi.org/10.32598/bcn.9.10.265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149954PMC
September 2019

Psychometric Properties of the Persian Translation of Video Gaming Addiction Test.

Basic Clin Neurosci 2019 Sep-Oct;10(5):469-474. Epub 2019 Sep 1.

Brain and Cogntive Clinic, Insitute for Cognitive Sciences Studies (ICSS), Tehran, Iran.

Introduction: The current study aims to measure the validity, reliability, and psychometric properties of the Persian translation of the Video Gaming Addiction Test (VAT).

Methods: A total of 280 young men (14-20 years old) (Mean±SD age: 17.22±1. Read More

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http://dx.doi.org/10.32598/bcn.9.10.345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149960PMC
September 2019

Spatial Learning and Memory in Barnes Maze Test and Synaptic Potentiation in Schaffer Collateral-CA1 Synapses of Dorsal Hippocampus in Freely Moving Rats.

Basic Clin Neurosci 2019 Sep-Oct;10(5):461-468. Epub 2019 Sep 1.

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Introduction: Synaptic plasticity has been suggested as the primary physiological mechanism underlying memory formation. Many experimental approaches have been used to investigate whether the mechanisms underlying Long-Term Potentiation (LTP) are activated during learning. Nevertheless, little evidence states that hippocampal-dependent learning triggers synaptic plasticity. Read More

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http://dx.doi.org/10.32598/bcn.9.10.330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149949PMC
September 2019

Protective Effects of Nucleobinding-2 After Cerebral Ischemia Via Modulating Bcl-2/Bax Ratio and Reducing Glial Fibrillary Acid Protein Expression.

Basic Clin Neurosci 2019 Sep-Oct;10(5):451-459. Epub 2019 Sep 1.

Addiction Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.

Introduction: Nucleobinding-2 (NUCB2) or nesfatin-1, a newly identified anorexigenic peptide, has antioxidant, anti-inflammatory, and anti-apoptotic properties. Brain ischemiareperfusion induces irreversible damages, especially in the hippocampus area. However, the therapeutic effects of NUCB2 have not been well investigated in cerebral ischemia. Read More

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http://dx.doi.org/10.32598/bcn.10.5.451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149952PMC
September 2019

An Algorithmic Model of Decision Making in the Human Brain.

Basic Clin Neurosci 2019 Sep-Oct;10(5):443-449. Epub 2019 Sep 1.

Department of Computer Engineering, Faculty of Engineering, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.

Introduction: One of the interesting topics in neuroscience is problem solving and decision-making. In this area, everything gets more complicated when events occur sequentially. One of the practical methods for handling the complexity of brain function is to create an empirical model. Read More

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http://dx.doi.org/10.32598/bcn.9.10.395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149951PMC
September 2019

Bumetanide Therapeutic Effect in Children and Adolescents With Autism Spectrum Disorder: A Review Study.

Basic Clin Neurosci 2019 Sep-Oct;10(5):433-441. Epub 2019 Sep 1.

Research Center for Cognitive and Behavioral Sciences, Tehran university of Medial Sciences, Tehran, Iran.

Introduction: Autism Spectrum Disorder (ASD) is characterized by several impairments in communications and social interactions, as well as restricted interests or stereotyped behaviors. Interventions applied for this disorder are based on multi-modal approaches, including pharmacotherapy. No definitive cure or medication has been introduced so far; therefore, researchers still investigate potential drugs for treating ASD. Read More

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http://dx.doi.org/10.32598/bcn.9.10.380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149950PMC
September 2019

Posterior Tibial Nerve Stimulation in Fecal Incontinence: A Systematic Review and Meta-Analysis.

Basic Clin Neurosci 2019 Sep-Oct;10(5):419-431. Epub 2019 Sep 1.

Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: The present systematic review and meta-analysis aims to investigate the role of Posterior Tibial Nerve Stimulation (PTNS) in the control of Fecal Incontinence (FI).

Methods: Two independent reviewers extensively searched in the electronic databases of Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, CINAHL, and Scopus for the studies published until the end of 2016. Only randomized clinical trials were included. Read More

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http://dx.doi.org/10.32598/bcn.9.10.290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149953PMC
September 2019

Brain Connectivity Reflected in Electroencephalogram Coherence in Individuals With Autism: A Meta-Analysis.

Basic Clin Neurosci 2019 Sep-Oct;10(5):409-417. Epub 2019 Sep 1.

Department of Biomedical Engineering, School of Electrical, Computer & Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.

Introduction: Many theories have been proposed about the etiology of autism. One is related to brain connectivity in patients with autism. Several studies have reported brain connectivity changes in autism disease. Read More

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http://dx.doi.org/10.32598/bcn.9.10.375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149956PMC
September 2019

Introducing Critical Pain-related Genes: A System Biology Approach.

Basic Clin Neurosci 2019 Jul-Aug;10(4):401-408. Epub 2019 Jul 1.

Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Pain is valuable in diagnosis and also warning of the patients. Many molecular reagents are introduced which are related to pain. In this research, the pain-related genes are screened to identify the critical ones. Read More

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http://dx.doi.org/10.32598/bcn.9.10.310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101522PMC

Effects of Dextromethorphan on Depressive-and Cognitive-Associated Behaviors: A Sexually Dimorphic Study.

Basic Clin Neurosci 2019 Jul-Aug;10(4):393-400. Epub 2019 Jul 1.

Department of Anatomy and Forensic Anthropology, Faculty of Basic Medical Sciences, Cross River University of Technology, Calabar, Nigeria.

Introduction: We investigated the sexually dimorphic effects of Dextromethorphan (DM) on cognitive and depression-like behaviors as well as on hippocampal histology in rats following acute administration.

Methods: Wistar rats of both sexes were treated with 25 or 50 mg/kg of DM for 7 days via intraperitoneal injection. At the end of the administration, behavioral studies were performed on the Tail Suspension Test (TST) for depressive-like behaviors and the Y-maze for cognitive behaviors. Read More

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http://dx.doi.org/10.32598/bcn.9.10.275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101514PMC

Gamma-Radiation-Induced Endoplasmic Reticulum Stress and Downregulation of WFS1, Nectin 3, and Sostdc1 Gene Expression in Mice Hippocampus.

Basic Clin Neurosci 2019 Jul-Aug;10(4):383-392. Epub 2019 Jul 1.

Department of Applied Zoology, Faculty of Science & Technology, Mangalore University, Mangalagangothri, Karnataka State, India.

Introduction: Neurogenesis mainly occurs in the hippocampus that is sensitive to radiation. More histological changes are reported at higher doses of radiation, while low dose radiation causes cognitive dysfunction in adult mammals. In the present study, we tried to correlate the Endoplasmic Reticulum (ER) stress-mediated hippocampus dysfunction after whole-body gamma radiation of mice. Read More

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http://dx.doi.org/10.32598/bcn.9.10.205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101521PMC

Role of Orexin-1 Receptor Within the Ventral Tegmental Area in Mediating Stress- and Morphine Priming-induced Reinstatement of Conditioned Place Preference in Rats.

Basic Clin Neurosci 2019 Jul-Aug;10(4):373-382. Epub 2019 Jul 1.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Orexin-containing neurons exist in the lateral hypothalamic region, sending their projections toward mesolimbic regions such as the Ventral Tegmental Area (VTA).

Methods: In the current study, a Reinstatement model is used to examine the effects of intra-VTA administration of SB334867 as an Orexin-1 Receptor (OX1R) antagonist on drug priming- and Forced Swim Stress (FSS)-induced reinstatement of morphine. Eighty-eight male adult albino Wistar rats, weighing 200-280 g, were bilaterally implanted by cannulas into the VTA. Read More

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http://dx.doi.org/10.32598/bcn.9.10.130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101517PMC

Introducing Genes With Significant Role in Migraine: An Interactomic Approach.

Basic Clin Neurosci 2019 Jul-Aug;10(4):363-372. Epub 2019 Jul 1.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Migraine is a severe kind of headache with the chance hereditary of 50%. Molecular studies can promote understanding of migraine pathophysiology. One of which is bioinformatics approach that could provide additional information related to the identified biomarkers. Read More

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http://dx.doi.org/10.32598/bcn.10.4.363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101513PMC

The Association of Balance, Fear of Falling, and Daily Activities With Drug Phases and Severity of Disease in Patients With Parkinson.

Basic Clin Neurosci 2019 Jul-Aug;10(4):355-362. Epub 2019 Jul 1.

Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.

Introduction: In the elderly, functional balance, fear of falling, and independence in daily living activities are interrelated; however, this relationship may change under the influence of drug phase and the severity of disease in individuals with idiopathic Parkinson disease. This study aimed to investigate the association of functional balance, fear of falling, and independence in the Activities of Daily Living (ADL) with the drug on- and drug off-phases.

Methods: A total of 140 patients with Parkinson disease (age: Mean±SD; 60. Read More

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http://dx.doi.org/10.32598/bcn.9.10.295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101520PMC

Upregulation of Glutamate Transporter 1 by Clavulanic Acid Administration and Attenuation of Allodynia and Hyperalgesia in Neuropathic Rats.

Basic Clin Neurosci 2019 Jul-Aug;10(4):345-354. Epub 2019 Jul 1.

Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Clavulanic acid (CLAV) is structurally similar to ceftriaxone, a potent stimulator of glial GlutamateTransporter-1 (GLT-1) expression. The present study aims at exploring the anti-nociceptive effects of CLAV, a beta-lactamase inhibitor in rats underwent sciatic nerve Chronic Constriction Injury (CCI).

Methods: CLAV (12. Read More

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http://dx.doi.org/10.32598/bcn.9.10.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101523PMC

The Effect of Muscle Graft With Nerve Growth Factor and Laminin on Sciatic Nerve Repair in Rats.

Basic Clin Neurosci 2019 Jul-Aug;10(4):333-344. Epub 2019 Jul 1.

Herbal Medicine Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.

Introduction: Peripheral nerve injury is one of the most common damages that lead to physical disability. Considering the similarity between the coatings of skeletal muscles and nerve fibers, we conducted this research to determine the effect of muscle graft with Nerve Growth Factor (NGF) and Laminin (L) on nerve repair.

Methods: We cut a 10-mm length of the sciatic nerve from 42 female Wistar rats (Weight: 200±250 g) and equally divided the rats into three groups. Read More

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http://dx.doi.org/10.32598/bcn.9.10.145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101516PMC

Morphine Exposure and Enhanced Depression-like Behaviour Confronting Chronic Stress in Adult Male Offspring Rat.

Basic Clin Neurosci 2019 Jul-Aug;10(4):323-332. Epub 2019 Jul 1.

Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Opioid addiction is an important concern in the World. Reports demonstrate that substance use disorder could influence genetic and environmental factors, and children of addicts have a higher rate of psychopathology. In this study, we investigated depression-like behavior among offspring of morphine-exposed rat parents. Read More

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http://dx.doi.org/10.32598/bcn.9.10.155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101512PMC

Comparing the Antinociceptive Effects of Methamphetamine, Buprenorphine, or Both After Chronic Treatment and Withdrawal in Male Rats.

Basic Clin Neurosci 2019 Jul-Aug;10(4):313-322. Epub 2019 Jul 1.

Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: Methamphetamine (Meth) and Buprenorphine (BUP) modulate pain perception. However, the antinociceptive effects of their interactions, which affect through different systems, are unclear in rats. This study aimed to compare the analgesic effects of Meth, BUP, and their coadministration, as well as the effect of withdrawal from these substances on nociception in male rats. Read More

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http://dx.doi.org/10.32598/bcn.9.10.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101515PMC

Involvement of Endogenous Opioid System in Swim Stress-Induced Pain Modulation During the Interphase of the Formalin Test.

Basic Clin Neurosci 2019 Jul-Aug;10(4):305-312. Epub 2019 Jul 1.

Neurosciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.

Introduction: Some evidence demonstrates endogenous inhibitory pathways of pain involved in the interphase (phase between early and later phase) of the formalin test. We previously showed that swimming stress modulates the pain-related behaviors during the interphase of the formalin test. In this study, we evaluated the role of the endogenous opioid system in modulating nociceptive responses of the formalin test. Read More

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http://dx.doi.org/10.32598/bcn.9.10.220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101518PMC

The Response of Ventral Tegmental Area Dopaminergic Neurons to Bupropion: Excitation or Inhibition?

Basic Clin Neurosci 2019 Jul-Aug;10(4):281-304. Epub 2019 Jul 1.

Neurophysiology Research Center, Urmia University of Medical Sciences, Urmia, Iran.

Introduction: Antidepressants can modulate brain monoamines by acting on pre-synaptic and postsynaptic receptors. Autoreceptors can reduce the monoamines effect on the somatodendritic or pre-synaptic regions despite its postsynaptic counter effects. The direct effect of some antidepressants is related to its temporal and spatial bioavailability in the vicinity of these receptors (still a matter of controversies). Read More

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http://dx.doi.org/10.32598/bcn.9.10.250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101519PMC

The Effects of Counting the Stride Numbers on the Parkinsonian Gait: Suggesting a Possible Reason for Dual Task Interference.

Basic Clin Neurosci 2019 May-Jun;10(3):269-279. Epub 2019 May 1.

Department of Mechatronics Engineering, School of Engineering Emerging Technologies, University of Tabriz, Tabriz, Iran.

Introduction: Parkinson Disease (PD) is a degenerative and progressive disorder of the central nervous system. It results from degeneration of Substantia Nigra pars compacta (SNc) of the Basal Ganglia (BG). Gait disturbances in PD patients generally get worse over time. Read More

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http://dx.doi.org/10.32598/bcn.9.10.245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712633PMC

The Effect of Prostration (Sajdah) on the Prefrontal Brain Activity: A Pilot Study.

Basic Clin Neurosci 2019 May-Jun;10(3):257-268. Epub 2019 May 1.

Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Introduction: "Sajdah", a prostration position, is part of Muslim daily prayers. It seems to have several effects on the brain and heart function. This study aimed to investigate the prefrontal brain activity after 10 seconds of Sajdah in the direction of Qibla (the direction that a Muslim prays) while putting the forehead on the ground. Read More

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http://dx.doi.org/10.32598/bcn.9.10.195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712630PMC
May 2019
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Comparing Steady-State Visually Evoked Potentials Frequency Estimation Methods in Brain-Computer Interface With the Minimum Number of EEG Channels.

Basic Clin Neurosci 2019 May-Jun;10(3):245-256. Epub 2019 May 1.

Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran.

Introduction: Brain-Computer Interface (BCI) systems provide a communication pathway between users and systems. BCI systems based on Steady-State Visually Evoked Potentials (SSVEP) are widely used in recent decades. Different feature extraction methods have been introduced in the literature to estimate SSVEP responses to BCI applications. Read More

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http://dx.doi.org/10.32598/bcn.9.10.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712635PMC