94 results match your criteria Basic and clinical andrology[Journal]


Testosterone replacement therapy and the risk of adverse cardiovascular outcomes and mortality.

Basic Clin Androl 2019 29;29. Epub 2019 Mar 29.

3Quantitative Health Sciences, Cleveland Clinic, Desk JJN3, Cleveland, Ohio 44195 USA.

Background: The risk of adverse cardiovascular events and mortality associated with testosterone replacement therapy is controversial. The purpose of this report was to evaluate the effect of testosterone replacement therapy (TRT) in men with secondary hypogonadism on the risk of myocardial infarction (MI), stroke (CVA) or all-cause mortality.

Methods: A retrospective cohort study was conducted using the Cleveland Clinic's electronic health record. Read More

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http://dx.doi.org/10.1186/s12610-019-0085-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440106PMC
March 2019
1 Read

Genetic causes of male infertility: snapshot on morphological abnormalities of the sperm flagellum.

Basic Clin Androl 2019 4;29. Epub 2019 Mar 4.

1INSERMU1016, CNRS UMR8104, Université Paris Descartes, 75014 Paris, France.

Male infertility due to Multiple Morphological Abnormalities of the sperm Flagella (MMAF), is characterized by nearly total asthenozoospermia due to the presence of a mosaic of sperm flagellar anomalies, which corresponds to short, angulated, absent flagella and flagella of irregular calibre. In the last four years, 7 novel genes whose mutations account for 45% of a cohort of 78 MMAF individuals were identified: , , , , , . This successful outcome results from the efficient combination of high-throughput sequencing technologies together with robust and complementary approaches for functional validation, in vitro, and in vivo using the mouse and unicellular model organisms such as the flagellated parasite . Read More

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http://dx.doi.org/10.1186/s12610-019-0083-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398242PMC
March 2019
6 Reads

Protective role of N-acetylcysteine (NAC) on human sperm exposed to etoposide.

Basic Clin Androl 2019 7;29. Epub 2019 Feb 7.

1Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

Background: Although recent progress in cancer treatment has increased patient survival and improved quality of life, reproductive side effects are still for concern. One way to decrease gonadal impairment is to use cytoprotectors. In testicular cancer, etoposide is generally used in combination with other agents, but there are no in-vitro studies of sperm exposure to etoposide and cytoprotectors, namely N-acetylcysteine (NAC). Read More

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http://dx.doi.org/10.1186/s12610-018-0082-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366041PMC
February 2019

Penile Lymphangioma: review of the literature with a case presentation.

Basic Clin Androl 2019 28;29. Epub 2019 Jan 28.

3Department of Vattikuti Urology Institute, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 USA.

Background: Penile lymphangiomas are rare manifestations of lymphangiomas or lymphatic malformations which are more commonly found in the head or neck region of the body. Lymphangiomas are further categorized as lymphangioma circumscriptum, cavernous lymphangioma, cystic hygroma, or acquired lymphangiomas (also known as lymphangiectasia), based on their depth and etiology.

Results: A literature review revealed only 30 cases of penile lymphangioma between 1947 and March 30, 2018. Read More

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http://dx.doi.org/10.1186/s12610-018-0081-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348653PMC
January 2019
2 Reads

The 100 most influential manuscripts in andrology: a bibliometric analysis.

Basic Clin Androl 2018 12;28:15. Epub 2018 Dec 12.

2Department of Urology, Cwm Taf University Health Board, Royal Glamorgan Hospital, Llantrisant, CF72 8XR UK.

Background: As the specialty of Andrology expands it is important to establish the most important studies that have shaped, and continue to shape, current research and clinical practice. Bibliometric analysis involving a citation rank list is an established means by which to identify the published material within a given field that has greatest intellectual influence. This bibliometric analysis sought to identify the 100 most influential manuscripts in Andrology, as well as the key research themes that have shaped contemporary understanding and management of andrological conditions. Read More

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https://bacandrology.biomedcentral.com/articles/10.1186/s126
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http://dx.doi.org/10.1186/s12610-018-0080-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290538PMC
December 2018
7 Reads

Effects of lipopolysaccharide-induced inflammation on hypoxia and inflammatory gene expression pathways of the rat testis.

Basic Clin Androl 2018 16;28:14. Epub 2018 Nov 16.

Monmouth University, 400 Cedar Avenue, West Long Branch, NJ 07764 USA.

Background: Bacterial infection and inflammation of the testis impairs fertility, yet an understanding of inflammatory responses of the testis is incomplete. We are interested in identifying gene pathways involved in the detection and clearance of infectious microbes in the male reproductive tract. In previous studies in our lab focused on hypoxia-responsive genes of the testis, preliminary experiments suggested that genes classically categorized as hypoxia genes are also activated during antimicrobial responses. Read More

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http://dx.doi.org/10.1186/s12610-018-0079-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238406PMC
November 2018

Epididymal approaches to male contraception.

Authors:
Joël R Drevet

Basic Clin Androl 2018 6;28:12. Epub 2018 Nov 6.

Laboratoire GReD "Génétique, Reproduction & Développement", UMR CNRS 6293, INSERM U1103, Université Clermont Auvergne (UCA), 28-Place Henri Dunant, bâtiment CRBC, 63000 Clermont-Ferrand, France.

Today, a vast arsenal of contraceptive methods interfering at different levels of the female reproductive axis is available. This is not the case for men for whom, until now, there is no reliable male reversible method and for whom vasectomy, condom and withdrawal are the only options available. Despite this limited supply, more than one third of all contraceptive methods used worldwide rely on the cooperation of the male partner. Read More

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http://dx.doi.org/10.1186/s12610-018-0078-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219163PMC
November 2018
16 Reads

Male reproductive health statement (XIIIth international symposium on Spermatology, may 9th-12th 2018, Stockholm, Sweden.

Basic Clin Androl 2018 29;28:13. Epub 2018 Oct 29.

22GReD Laboratory INSERM U1103 - CNRS UMR6293, Faculty de Medicine, CRBC, Université Clermont Auvergne (UCA), 63000 Clermont-Ferrand, France.

On the occasion of the held from 9 to 13 May 2018 in Stockholm (Sweden), participants (guest speakers and audience) collectively felt the need to make a public statement on the general issue of male reproductive health. Our intention is to raise awareness of what we believe is a neglected area of research despite alarming situations around the world. The disclosure strategy desired by the co-authors is to bring it to the attention of the greatest number partly by considering co-publication in the various periodicals dealing with Reproductive Biology and Andrology. Read More

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https://bacandrology.biomedcentral.com/articles/10.1186/s126
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http://dx.doi.org/10.1186/s12610-018-0077-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205799PMC
October 2018
27 Reads

Gel electrophoresis of human sperm: a simple method for evaluating sperm protein quality.

Basic Clin Androl 2018 3;28:10. Epub 2018 Sep 3.

1EA 4308 - GQG - Gametogenesis and gamete quality, University of Lille, F-59000 Lille, France.

Background: The limitations of conventional sperm analyses have highlighted the need for additional means of evaluating sperm quality.

Methods: In a study of a cohort of 245 men with known conventional sperm parameters, one-dimensional PAGE was used to monitor protein content and quality in samples from individual ejaculates.

Results: The sperm protein content varied markedly from sample to another, especially in the high-molecular-weight range. Read More

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https://bacandrology.biomedcentral.com/articles/10.1186/s126
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http://dx.doi.org/10.1186/s12610-018-0076-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120067PMC
September 2018
15 Reads

Sperm cryopreservation incidence in men with testicular cancer: towards a stabilization in testicular cancer incidence? Results from the CECOS network.

Basic Clin Androl 2018 3;28:11. Epub 2018 Aug 3.

Université de Toulouse, UPS, Groupe de Recherche en Fertilité Humaine (EA 3694, Human Fertility Research Group), TSA 70034, 31059 Toulouse Cedex 9, France.

Background: Testicular cancer (TC) represents 1% of all new male cancer cases but remains the most frequent cancer in adolescents and young adults in industrialized countries. In this study, we assessed time trends in use of sperm cryopreservation by men with TC from 1990 to 2013 in France.

Methods: We collected data from patients diagnosed with TC who underwent sperm cryopreservation in the French national network of sperm banks. Read More

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http://dx.doi.org/10.1186/s12610-018-0075-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091093PMC
August 2018
17 Reads

A change from gonadotropin releasing hormone antagonist to gonadotropin releasing hormone agonist therapy does not affect the oncological outcomes in hormone sensitive prostate cancer.

Basic Clin Androl 2018 18;28. Epub 2018 Jul 18.

1Department of Urology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585 Japan.

Background: The aim of our retrospective study was to evaluate the 5-year survival and time to castration resistant prostate cancer in patients with hormone sensitive prostate cancer treated with the gonadotropin releasing hormone antagonist, degarelix. Another aim was to evaluate the effects of changing the treatment from degarelix to a gonadotropin releasing hormone agonist after achieving stable disease control, on the clinical and oncological outcomes.

Results: Our analysis was based on the data of 108 patients with prostate cancer who were treated with degarelix. Read More

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http://dx.doi.org/10.1186/s12610-018-0074-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050721PMC

Testicular microlithiasis and testicular tumor: a review of the literature.

Basic Clin Androl 2018 9;28. Epub 2018 Jul 9.

1Department of Urology, CHRU Nancy, Nancy, France.

Introduction: There are numerous scientific publications on testicular microlithiasis (TML) detected during ultrasound (US) examination. We wished to update the data.

Methods: PubMed was used to identify original articles published between 1998 and May 2017 describing the association between TML and testicular tumor. Read More

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https://bacandrology.biomedcentral.com/articles/10.1186/s126
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http://dx.doi.org/10.1186/s12610-018-0073-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036676PMC
July 2018
6 Reads

The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review.

Basic Clin Androl 2018 20;28. Epub 2018 Jun 20.

1Aix Marseille Univ, Inserm, MMG, U1251, Marseille Medical Genetics, 13385 Marseille, France.

The nuclear lamina (NL) is a filamentous protein meshwork, composed essentially of lamins, situated between the inner nuclear membrane and the chromatin. The NL is a component of the nuclear envelope, interacts with a wide range of proteins and is required for normal nuclear structure and physiological development. During spermiogenesis the spermatid nucleus is elongated, and dramatically reduced in size with protamines replacing histones to produce a highly compacted chromatin. Read More

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http://dx.doi.org/10.1186/s12610-018-0072-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008938PMC
June 2018
2 Reads

Understanding the seminal plasma proteome and its role in male fertility.

Basic Clin Androl 2018 4;28. Epub 2018 Jun 4.

1Department of Surgery, Division of Urology, Universidade Federal de São Paulo, R Embau, 231, Sao Paulo, SP 04039-060 Brazil.

Seminal plasma is a complex fluid comprised of secretions from the seminal vesicles, the prostate, bulbourethral glands and from the seminiferous tubule lumen / epididymides / . While it has been established that seminal plasma serves not only as a medium to carry, protect, and nourish sperm after ejaculation up to fertilization, but also as a functional modulator of sperm function, there is still a need to properly characterize the molecular make-up of seminal plasma in fertile men, and to understand how this is altered in different causes of male infertility. The main purpose of this manuscript was to review articles that studied the human seminal plasma proteome, ranging from characterizing a fertile seminal plasma proteomic map to studies comparing seminal plasma from fertile and infertile men, and comparing seminal plasma of fertile or normozoospermic men to a diverse range of biological causes for male infertility. Read More

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http://dx.doi.org/10.1186/s12610-018-0071-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985566PMC
June 2018
7 Reads

Is sperm FISH analysis still useful for Robertsonian translocations? Meiotic analysis for 23 patients and review of the literature.

Basic Clin Androl 2018 7;28. Epub 2018 May 7.

CHU de Grenoble, UF de Biologie de la procréation, F-38000 Grenoble, France.

Background: Robertsonian translocations (RobT) are common structural chromosome rearrangements where carriers display a majority of chromosomally balanced spermatozoa from alternate segregation mode. According to some monotony observed in the rates of balanced segregation, is sperm FISH analysis obsolete for RobT carriers?

Methods: Retrospective cohort research study on 23 patients analyzed in our center from 2003 to 2017 and compared to the data of 187 patients in literature from 1983 to 2017.Robertsonian translocation carriers were divided in six groups according to the chromosomes involved in the translocation: 9 patients from our center and 107 from literature carrying 45,XY,der(13;14) karyotype, 3 and 35 patients respectively with 45,XY,der(14;21), 5 and 11 patients respectively with 45,XY,der(13;15), 4 and 7 patients respectively with 45,XY,der(14;15), 1 and 4 patients respectively with 45,XY,der(13;22),and 1 and 10 patients respectively with 45,XY,der(14;22). Read More

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http://dx.doi.org/10.1186/s12610-018-0069-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937048PMC
May 2018
11 Reads

Sperm aneuploidy and DNA fragmentation in unexplained recurrent pregnancy loss: a multicenter case-control study.

Basic Clin Androl 2018 2;28. Epub 2018 Apr 2.

1Research Group on Human Fertility EA 3694, University Paul Sabatier Toulouse III, 330 av Grande Bretagne, 31059 Toulouse, France.

Background: Recurrent pregnancy loss (RPL) is defined as the loss of at least three pregnancies in the first trimester. Although the most common cause is embryo aneuploidy, and despite female checkup and couple karyotyping, in about 50% of cases RPL remain unexplained. Male implication has little been investigated and results are discordant. Read More

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http://dx.doi.org/10.1186/s12610-018-0070-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879915PMC
April 2018
4 Reads

Longer trinucleotide repeats of androgen receptor are associated with higher testosterone and low oxytocin levels in diabetic premature ejaculatory dysfunction patients.

Basic Clin Androl 2018 6;28. Epub 2018 Mar 6.

7Department of Medical Biochemistry, Ege University School of Medicine, Bornova, Izmir Turkey.

Background: Despite its worldwide high occurrence, the obscurity regarding the description, epidemiology and management of premature ejaculation remains provocative. It is well established that male premature ejaculatory dysfunction is an increasing problem due to spontaneous ejaculation across a variety of general and clinical subjects. The main goal of this study was to determine the relationships between trinucleotide repeats of the androgen receptor (AR), sex steroids, and pituitary hormones with sexual function in men with type 2 diabetes mellitus (DM) and reported with acquired premature ejaculation (PE). Read More

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http://dx.doi.org/10.1186/s12610-018-0068-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838858PMC
March 2018
11 Reads

Curative GnRHa treatment has an unexpected repressive effect on Sertoli cell specific genes.

Basic Clin Androl 2018 9;28. Epub 2018 Feb 9.

Cryptorchidism Research Institute, Kindermedizinisches Zentrum Liestal, 4410 Liestal, Switzerland.

Background: Follicle stimulating hormone and testosterone stimulate Sertoli cells to support germ cell function and differentiation. During mini-puberty, when gonadotropin (GnRH) stimulates increases in plasma luteinizing hormone (LH) and testosterone levels, gonocytes are transformed into Ad spermatogonia. In cryptorchidism, impaired gonadotropin secretion during mini-puberty results in insufficient LH and testosterone secretion, impaired gonocyte transition to Ad spermatogonia, and perturbed Sertoli cell proliferation. Read More

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http://dx.doi.org/10.1186/s12610-018-0067-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806254PMC
February 2018
15 Reads

Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report.

Basic Clin Androl 2018 25;28. Epub 2018 Jan 25.

1Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562 Japan.

Background: Although oncologic testicular sperm extraction (onco-TESE) has been increasingly practiced, the evidence of onco-TESE performed in patients with testicular cancer is insufficient. Furthermore, in bilateral testicular cancer, accounting for 0.5%-1% of testicular cancers, onco-TESE is more challenging and has been insufficiently reported. Read More

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http://dx.doi.org/10.1186/s12610-018-0066-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785797PMC
January 2018
35 Reads

On the descent of the epididymo-testicular unit, cryptorchidism, and prevention of infertility.

Basic Clin Androl 2017 14;27:21. Epub 2017 Nov 14.

Cryptorchidism Research Institute, Kindermedizinisches Zentrum Liestal, Liestal, Switzerland.

This comprehensive review provides in-depth coverage of progress made in understanding the molecular mechanisms underlying cryptorchidism, a frequent pathology first described in about 1786 by John Hunter. The first part focuses on the physiology, embryology, and histology of epididymo-testicular descent. In the last 20 years epididymo-testicular descent has become the victim of schematic drawings with an unjustified rejection of valid histological data. Read More

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https://bacandrology.biomedcentral.com/articles/10.1186/s126
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http://dx.doi.org/10.1186/s12610-017-0065-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686796PMC
November 2017
4 Reads

Paternal obesity: how bad is it for sperm quality and progeny health?

Basic Clin Androl 2017 26;27:20. Epub 2017 Oct 26.

Université Cote d'Azur, Inserm, C3M (team 10), Nice, France.

There is substantial evidence that paternal obesity is associated not only with an increased incidence of infertility, but also with an increased risk of metabolic disturbance in adult offspring. Apparently, several mechanisms may contribute to the sperm quality alterations associated with paternal obesity, such as physiological/hormonal alterations, oxidative stress, and epigenetic alterations. Along these lines, modifications of hormonal profiles namely reduced androgen levels and elevated estrogen levels, were found associated with lower sperm concentration and seminal volume. Read More

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http://dx.doi.org/10.1186/s12610-017-0064-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657098PMC
October 2017
2 Reads

Occurrence and reproductive roles of hormones in seminal plasma.

Basic Clin Androl 2017 8;27:19. Epub 2017 Sep 8.

Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic.

Only 2-5% of seminal fluid is composed of spermatozoa, while the rest is seminal plasma. The seminal plasma is a rich cocktail of organic and inorganic compounds including hormones, serving as a source of nutrients for sperm development and maturation, protecting them from infection and enabling them to overcome the immunological and chemical environment of the female reproductive tract. In this review, a survey of the hormones found in human seminal plasma, with particular emphasis on reproductive hormones is provided. Read More

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http://dx.doi.org/10.1186/s12610-017-0062-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640966PMC
September 2017
5 Reads

ICSI diagnostic: a way to prevent total fertilization failure after 4 unsuccessful IUI.

Basic Clin Androl 2017 21;27:18. Epub 2017 Sep 21.

A.R.T medical Team of C.H.C. St Vincent, 4000 Rocourt, Belgium.

Background: The aim of this retrospective study is to investigate the relevance of dividing oocytes and using some for traditional in vitro fertilization (IVF) and others for intracytoplasmic sperm injection (ICSI) as of the first IVF cycle in patients with unexplained infertility who have undergone 4 intrauterine insemination (IUI) cycles which produced no pregnancies.

Methods: This retrospective study includes patients with unexplained infertility who have failed to become pregnant, after 4 IUI, despite normal semen parameters after sperm capacitation. These women were treated in our assisted fertilization program from 2008 until 2015. Read More

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http://dx.doi.org/10.1186/s12610-017-0061-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612332PMC
September 2017
25 Reads

Patterns of residual HIV-1 RNA shedding in the seminal plasma of patients on effective antiretroviral therapy.

Basic Clin Androl 2017 8;27:17. Epub 2017 Sep 8.

Université de Toulouse, UPS, Groupe de Recherche en Fertilité Humaine (EA 3694, Human Fertility Research Group), Toulouse, France.

Background: More and more HIV-1-infected men on effective antiretroviral treatment (ART) have unprotected sex in order to procreate. The main factor influencing transmission is seminal HIV shedding. While the risk of HIV transmission is very low, it is difficult to assess in individuals. Read More

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http://dx.doi.org/10.1186/s12610-017-0063-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590187PMC
September 2017
9 Reads

Sleep disturbances and semen quality in an Italian cross sectional study.

Basic Clin Androl 2017 21;27:16. Epub 2017 Aug 21.

Dipartimento della Donna, del Neonato e del Bambino, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Commenda 12, 20122 Milano, Italy.

Introduction: In order to obtain information about the relationship between sleep disturbances and sperm parameters, we analyzed data from a study conducted in a Italian Fertility Clinic, in men of couples seeking help for infertility.

Patients And Methods: Male partners with or without a medical history of reproductive organ diseases (cryptorchidism, varicocele, orchitis, testicular torsion) were eligible for the study. There were 382 men evaluated from May 2014 to November 2016, all of whom completed a self-administered questionnaire on general lifestyle habits. Read More

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http://dx.doi.org/10.1186/s12610-017-0060-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563907PMC
August 2017
11 Reads

Relationship between Semenogelins bound to human sperm and other semen parameters and pregnancy outcomes.

Basic Clin Androl 2017 8;27:15. Epub 2017 Aug 8.

Center for IVF and Infertility, International University of Health and Welfare Hospital, Nasushiobara, Japan.

Background: Semenogelins (SEMGs) are major components of human seminal vesicle secretions. Due to SEMG's sperm-motility inhibitor, a significant negative correlation between sperm motility and the proportion of SEMG-bound spermatozoa (SEMG+) was found in asthenozoospermic patients. SEMGs also show intrinsic inhibitory capability for sperm capacitation; however, studies on actual clinical specimens have not been conducted. Read More

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http://dx.doi.org/10.1186/s12610-017-0059-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547539PMC
August 2017
5 Reads

Association of admission testosterone level with ST-segment resolution in male patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.

Basic Clin Androl 2017 21;27:14. Epub 2017 Jul 21.

Cardiology Department, Cardiovascular Research Center, Tabriz University of Medical science, Madani Heart Center, Daneshgah Ave, Tabriz, Iran.

Background: Low level of testosterone may be associated with cardiovascular diseases in men, as some evidence suggests a protective role for testosterone in cardiovascular system. Little is known about the possible role of serum testosterone in response to reperfusion therapy in ST-elevation myocardial infarction (STEMI) and its relationship with ST-segment recovery. The present study was conducted to evaluate the association of serum testosterone levels with ST-segment resolution following primary percutaneous coronary intervention (PPCI) in male patients with acute STEMI. Read More

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http://dx.doi.org/10.1186/s12610-017-0058-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532774PMC
July 2017
26 Reads

Hypogonadotropic hypogonadism in men with hereditary hemochromatosis.

Basic Clin Androl 2017 8;27:13. Epub 2017 Jul 8.

Laboratoire de Biologie de la Reproduction, CECOS Lorraine, CHU Nancy, Nancy, France.

Hereditary hemochromatosis is a genetic disease that progresses silently. This disease is often diagnosed late when complications appear. Hypogonadotropic hypogonadism (HH) is one of the classical complications of hemochromatosis. Read More

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http://dx.doi.org/10.1186/s12610-017-0057-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501943PMC
July 2017
9 Reads

Does sperm quality and DNA integrity differ in cryopreserved semen samples from young, adult, and aged Nellore bulls?

Basic Clin Androl 2017 21;27:12. Epub 2017 Jun 21.

FMVA, Faculty of Veterinary Medicine, UNESP - Univ Estadual Paulista, São José do Rio Preto, Brazil.

Background: In humans, it is now well documented that rising paternal age is correlated with decreased sperm DNA integrity and embryonic developmental failures. On the other side of the coin, it is also reported that very young fathers such as teenagers carry an increased risk of adverse birth outcomes. These observations suggest that, at least in humans, there is an age window for optimal sperm DNA integrity. Read More

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http://dx.doi.org/10.1186/s12610-017-0056-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479005PMC
June 2017
4 Reads

Subinguinal microsurgical varicocelectomy vs. percutaneous embolization in infertile men: Prospective comparison of reproductive and functional outcomes.

Basic Clin Androl 2017 8;27:11. Epub 2017 Jun 8.

Department of Urology, Toulouse university hospital, 1, avenue Jean Poulhès - TSA 50032, 31059 Toulouse cedex 9, France.

Background: Varicocele is a condition characterized by dilated, tortuous veins within the pampiniform venous plexus of the scrotal sac. Presence of varicocele is associated with an increased risk of alteration of semen parameters. The objective of this study was to compare the current standard in varicocele treatment procedures: sub-inguinal microscopic ligation to percutaneous embolization in terms of semen parameters improvement, fertility, and morbidity at the university hospital of Toulouse (France). Read More

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http://dx.doi.org/10.1186/s12610-017-0055-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463394PMC
June 2017
40 Reads

"This is where it all started" - the pivotal role of PLCζ within the sophisticated process of mammalian reproduction: a systemic review.

Basic Clin Androl 2017 21;27. Epub 2017 May 21.

IVF Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.

Mammalian reproduction is one of the most complex and fascinating biological phenomenon, which aims to transfer maternal and paternal genetic material to the next generation. At the end of oogenesis and spermatogenesis, both haploid gametes contain a single set of chromosomes ready to form the zygote, the first cell of the newly developing individual. The mature oocyte and spermatozoa remain in a quiescent state, during which the oocyte is characterized by nuclear and cytoplasmic arrest, while the spermatozoa necessitates further maturation within the epididymis and female reproductive track prior to egg fertilization. Read More

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http://dx.doi.org/10.1186/s12610-017-0054-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438850PMC
May 2017
5 Reads

Interactions between oestrogen and 1α,25(OH)-vitamin D signalling and their roles in spermatogenesis and spermatozoa functions.

Basic Clin Androl 2017 8;27:10. Epub 2017 May 8.

INRA, OeReCa, Normandie University, UNICAEN, 14000 Caen, France.

Oestrogens and 1α,25(OH)-vitamin D (1,25-D) are steroids that can provide effects by binding to their receptors localised in the cytoplasm and in the nucleus or the plasma membrane respectively inducing genomic and non-genomic effects. As confirmed notably by invalidation of the genes, coding for their receptors as tested with mice with in vivo and in vitro treatments, oestrogens and 1,25-D are regulators of spermatogenesis Moreover, some functions of ejaculated spermatozoa as viability, DNA integrity, motility, capacitation, acrosome reaction and fertilizing ability are targets for these hormones. The studies conducted on their mechanisms of action, even though not completely elicited, have allowed the demonstration of putative interactions between their signalling pathways that are worth examining more closely. Read More

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http://dx.doi.org/10.1186/s12610-017-0053-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421336PMC
May 2017
38 Reads

Cell-free and intracellular nucleic acids: new non-invasive biomarkers to explore male infertility.

Basic Clin Androl 2017 21;27. Epub 2017 Apr 21.

Unité INSERM U1203, Hôpital Saint Eloi, CHRU Montpellier, 80, avenue Fliche, 34295 Montpellier, France.

Male infertility is a devastating problem that affects many couples worldwide. However, the molecular mechanisms and causes of idiopathic male infertility remain unclear. Circulating cell-free nucleic acids have an important role in human physiology and emerging evidence suggests that they play a role in male infertility. Read More

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http://dx.doi.org/10.1186/s12610-017-0052-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399401PMC
April 2017
8 Reads

Reversibility of Vasalgel™ male contraceptive in a rabbit model.

Basic Clin Androl 2017 5;27. Epub 2017 Apr 5.

Seraphim Life Sciences Consulting, LLC, 2158 Bonaventure Drive, Suite 101, Vienna, VA 22181 USA.

Background: Development of a non-hormonal long-acting reversible contraceptive for men could have a significant impact on reducing unintended pregnancies. Vasalgel™ is a high molecular weight polymer consisting of styrene-alt-maleic acid (SMA) dissolved in dimethyl sulfoxide being developed as a reversible male contraceptive device. It forms a hydrogel when implanted into the vasa deferentia, which prevents the passage of sperm. Read More

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http://dx.doi.org/10.1186/s12610-017-0051-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381074PMC
April 2017
1 Read

Processing and selection of surgically-retrieved sperm for ICSI: a review.

Basic Clin Androl 2017 21;27. Epub 2017 Mar 21.

Centre for Reproductive Medicine, UZ Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium.

Although the technique of intracytoplasmic sperm injection (ICSI) has been a revolution in the alleviation of male infertility, the use of testicular sperm for ICSI was a formerly unseen breakthrough in the treatment of the azoospermic man with primary testicular failure. At the clinical level, different procedures of testicular sperm retrieval (conventional TESE, micro-TESE, FNA/TESA, MESA, PESA) are being performed, the choice is mainly based on the cause of azoospermia (obstructive versus non-obstructive) and the surgeon's skills. At the level of the IVF laboratory, mechanical procedures to harvest the sperm from the tissue may be combined with enzymatic treatment in order to increase the sperm recovery rates. Read More

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http://dx.doi.org/10.1186/s12610-017-0050-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360083PMC
March 2017
16 Reads

Metabolic endotoxaemia related inflammation is associated with hypogonadism in overweight men.

Basic Clin Androl 2017 8;27. Epub 2017 Mar 8.

School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, 5001 South Australia.

Background: Obesity is associated with both impaired testosterone production and a chronic state of low grade inflammation. Previously it was believed that this inflammation was mediated by a decline in the immunosuppressive action of testosterone. However, more recently an alternative hypothesis (GELDING theory) has suggested that inflammation originating from the passage of intestinal bacteria into the circulation (metabolic endotoxaemia) may actually be the cause of impaired testicular function in obese men. Read More

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http://dx.doi.org/10.1186/s12610-017-0049-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341351PMC
March 2017
1 Read

Predictive value of sperm deoxyribonucleic acid (DNA) fragmentation index in male infertility.

Basic Clin Androl 2017 21;27. Epub 2017 Feb 21.

Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Diponegoro no. 71, Central Jakarta, Indonesia.

Background: Recently, damage to the sperm DNA has been studied as it is associated with reduced fertilization rates, embryo quality, and pregnancy rates, also higher rates of spontaneous miscarriage.

Objective: To develop a diagnostic method in predicting male infertility.

Material And Methods: The design of this study is cross-sectional. Read More

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http://dx.doi.org/10.1186/s12610-016-0046-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319071PMC
February 2017
1 Read

The contraceptive efficacy of intravas injection of Vasalgel™ for adult male rhesus monkeys.

Basic Clin Androl 2017 7;27. Epub 2017 Feb 7.

California National Primate Research, University of California, One Shields Ave, Davis, CA 95616 USA.

Background: Options for male contraception are limited. The purpose of this study was to use a nonhuman primate model to evaluate Vasalgel™, a high molecular weight polymer being developed as a contraceptive device for men.

Methods: Sixteen adult male rhesus monkeys received intravas injections of Vasalgel, consisting of 25% styrene maleic acid in dimethyl sulfoxide. Read More

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http://dx.doi.org/10.1186/s12610-017-0048-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294830PMC
February 2017
3 Reads

Sperm quality and paternal age: effect on blastocyst formation and pregnancy rates.

Basic Clin Androl 2017 21;27. Epub 2017 Jan 21.

ART/PGD Division, CHU Montpellier, Montpellier, F-34295 France ; INSERM U1203, Montpellier, F-34295 France ; Montpellier University, UFR of Medicine, Montpellier, France.

Background: Several studies suggest a decrease in sperm quality in men in the last decades. Therefore, the aim of this work was to assess the influence of male factors (sperm quality and paternal age) on the outcomes of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).

Methods: This retrospective study included all couples who underwent IVF or ICSI at Montpellier University Hospital, France, between 1 January 2010 and 31 December 2015. Read More

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http://dx.doi.org/10.1186/s12610-016-0045-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5251225PMC
January 2017
21 Reads

Hormonal, chemical and thermal inhibition of spermatogenesis: contribution of French teams to international data with the aim of developing male contraception in France.

Basic Clin Androl 2017 13;27. Epub 2017 Jan 13.

Biologie de la Reproduction, Centre Hospitalier Universitaire Cochin, 123 Bd de Port Royal, 75014 Paris, France.

Since the 1970s, international research on male contraception has been actively pursued. Hormonal and non-hormonal methods (thermal, chemical) have been tested, leading to clinical trials of interest to thousands of men and couples. The results showed that it was possible to develop methods of male contraception that inhibited spermatogenesis with good contraceptive efficacy. Read More

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http://bacandrology.biomedcentral.com/articles/10.1186/s1261
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http://dx.doi.org/10.1186/s12610-016-0047-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237323PMC
January 2017
2 Reads

Mammalian sperm nuclear organization: resiliencies and vulnerabilities.

Basic Clin Androl 2016 21;26:17. Epub 2016 Dec 21.

GReD "Genetics, Reproduction & Development" Laboratory, UMR CNRS 6293, INSERM U1103, Clermont Université, BP60026 - TSA60026, 63178 Aubière cedex, France.

Sperm cells are remarkably complex and highly specialized compared to somatic cells. Their function is to deliver to the oocyte the paternal genomic blueprint along with a pool of proteins and RNAs so a new generation can begin. Reproductive success, including optimal embryonic development and healthy offspring, greatly depends on the integrity of the sperm chromatin structure. Read More

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http://dx.doi.org/10.1186/s12610-016-0044-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175393PMC
December 2016
2 Reads

Sperm DNA damage and its role in IVF and ICSI.

Basic Clin Androl 2016 5;26:15. Epub 2016 Dec 5.

Department of Urology, Weill Cornell Medicine, 525 East 68th Street, Starr 900, New York, NY 10065 USA.

While the semen analysis has traditionally been relied upon to differentiate fertile and infertile men, its utility has been questioned in the current era of assisted reproductive technologies. The desire for more sophisticated diagnostic and predictive tools has led to increased use of sperm DNA damage in the management of male infertility. Despite the availability of numerous assays to measure sperm DNA damage, our understanding of the etiology, measurement, and clinical implications of sperm DNA damage remains incomplete. Read More

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http://dx.doi.org/10.1186/s12610-016-0043-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137216PMC
December 2016
2 Reads

Literature review of vaccine-related adverse events reported from HPV vaccination in randomized controlled trials.

Basic Clin Androl 2016 21;26:16. Epub 2016 Nov 21.

Vattikuti Urology Institute, Henry Ford Hospital, 2799 W. Grand Blvd, Detroit, MI 48202 USA.

Background: The human papilloma virus (HPV) infections were addressed with two FDA-approved HPV vaccines: quadrivalent and bivalent vaccine. The objective of this manuscript is to determine the safety of the HPV vaccine.

Results: A search of PubMed articles for "human papillomavirus vaccine" was used to identify all-type HPV clinical studies prior to October 2014. Read More

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http://dx.doi.org/10.1186/s12610-016-0042-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116857PMC
November 2016
3 Reads

Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report.

Basic Clin Androl 2016 8;26:14. Epub 2016 Nov 8.

Department of Andrology, Lille University Hospital, Lille, France ; EA4308 Gametogenesis and Gamete Quality, University of Lille, Lille, France.

Background: Secreting interstitial cell (Leydig cell) tumors are rare. In adults, the clinical picture and steroid levels are variable.

Case Presentation: This paper presents a case of left testicular tumor, showing azoospermia with normal serum level of total testosterone, collapsed FSH and LH, and high delta4 androstenedione. Read More

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http://dx.doi.org/10.1186/s12610-016-0041-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100078PMC
November 2016
1 Read

Gonadal response after a single-dose stimulation test with recombinant human chorionic gonadotropin (rhCG) in patients with isolated prepubertal cryptorchidism.

Basic Clin Androl 2016 28;26:13. Epub 2016 Oct 28.

Pediatric Endocrinology Unit, Pediatrics Department, Irmandade da Santa Casa de Misericórdia de São Paulo, and Santa Casa de São Paulo School of Medical Sciences, Rua Dr. Cesário Mota Jr, 112, Vila Buarque, São Paulo, CEP 01221-020 Brazil.

Background: The evaluation of prepubertal gonadal Leydig cells secretion requires gonadotropin stimulation. Urinary hCG (human chorionic gonadotropin) is currently unavailable in many countries, however, recombinant hCG (rhCG) can be used. Our aim was to evaluate rhCG-stimulated testicular hormones in a group of patients with cryptorchidism. Read More

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http://dx.doi.org/10.1186/s12610-016-0039-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084384PMC
October 2016
1 Read

To be or not to be [fertile], that is the question.

Basic Clin Androl 2016 12;26:12. Epub 2016 Oct 12.

Department of Reproductive Biology, Cytogenetics and Gynaecology, Poissy General Hospital, F-78303 Poissy, France ; EA7404-GIG, UFR des Sciences de la Santé Simone Veil, Université Paris-Saclay, Montigny le Bretonneux, France.

Background: According to our literature analysis, there are no data focused on spermatozoa emotional representations in childless men and data on the emotional repercussions of a diagnosis of infertility on men are still scarce. Thus, in this work, we investigated what the presence or absence of spermatozoa in the semen symbolize for men.

Material And Methods: To answer this question, 441 childless heterosexual men participated in an anonymous, prospective, Internet-based survey. Read More

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http://dx.doi.org/10.1186/s12610-016-0040-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059960PMC
October 2016

Sperm DNA damage and assisted reproductive technologies: reasons to be cautious!

Authors:
Joël R Drevet

Basic Clin Androl 2016 27;26:11. Epub 2016 Sep 27.

GReD Laboratory, CNRS UMR6293 - INSERM U1103 - Clermont Université, Clermont-Ferrand, France.

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http://dx.doi.org/10.1186/s12610-016-0038-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037879PMC
September 2016
1 Read
1 Citation

Zinner's syndrome: report of two cases and review of the literature.

Basic Clin Androl 2016 20;26:10. Epub 2016 Sep 20.

Urology B Ibn Sina Hospital, Mohammed V University, Rabat, Morocco.

Background: Congenital malformations of the seminal vesicle are uncommon, and most of them are cystic malformations. If an insult occurs between the 4th and the 13 h gestational week, the embryogenesis of the kidney, ureter, seminal vesicle, and vas deferens could be altered. Cysts of the seminal vesicle may appear with a mass effect, dysuria, epididymitis, or obstruction of the gastrointestinal and genitourinary tracts. Read More

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http://dx.doi.org/10.1186/s12610-016-0037-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028972PMC
September 2016
16 Reads

A pilot study about infertile men's awareness of their reprotoxic exposures and the intervention of occupational medicine to assess them.

Basic Clin Androl 2016 10;26. Epub 2016 Aug 10.

CECOS Laboratory of Reproductive Biology, AP-HM La Conception, Pole femmes parents enfants, Marseille, France ; Aix Marseille Univ, CNRS, IRD, IMBE, Marseille, France.

Background: Male infertility related to professional reprotoxic exposure has been assessed in several studies. Collaboration between occupational physicians and patients can yield information about the preventive measures that can be taken to avoid such exposure. The use of preventive measures is determined by the collaboration between reproductive medicine and occupational medicine and also by the patient's awareness of reprotoxic occupational exposures. Read More

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http://dx.doi.org/10.1186/s12610-016-0036-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979153PMC
August 2016
11 Reads

Is intracouple assisted reproductive technology an option for men with large-headed spermatozoa? A literature review and a decision guide proposal.

Basic Clin Androl 2016 8;26. Epub 2016 Jul 8.

GIG, EA7404, Université Versailles St Quentin en Yvelines, Montigny le Bretonneux, France.

Although the presence of spermatozoa with an abnormally large head is rare, it is associated with low fertility or even total infertility. We reviewed the literature on assisted reproductive technology (ART) strategies and outcomes for men with large-headed spermatozoa. We also discuss additional analyses that can usefully characterize sperm defects and help with the choice between intra-couple ART and insemination with donor sperm. Read More

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http://dx.doi.org/10.1186/s12610-016-0035-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939046PMC
July 2016
7 Reads