115 results match your criteria Basic and clinical andrology[Journal]


Hard flaccid syndrome: state of current knowledge.

Basic Clin Androl 2020 4;30. Epub 2020 Jun 4.

Department of urology, Clinique Turin, Paris, France.

Introduction: Hard-flaccid syndrome is gaining increased interest among male sexual dysfunctions in the last years. It is poorly understood and defined. Most of the information comes from online forums. Read More

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http://dx.doi.org/10.1186/s12610-020-00105-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271516PMC

Associations of bedtime, sleep duration, and sleep quality with semen quality in males seeking fertility treatment: a preliminary study.

Basic Clin Androl 2020 23;30. Epub 2020 Apr 23.

1Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark.

Background: Poor sleep has been linked to a number of adverse health outcomes. Recent studies suggest that late bedtimes, short or long sleep durations, and poor sleep quality may impair semen quality. No study has previously explored all three factors in relation to semen quality. Read More

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http://dx.doi.org/10.1186/s12610-020-00103-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181488PMC

Efficacy of relaxin for cisplatin-induced testicular dysfunction and epididymal spermatotoxicity.

Basic Clin Androl 2020 9;30. Epub 2020 Mar 9.

5Division of Animal Science, Kitasato University School of Veterinary Medicine, Towada, 034-8628 Japan.

Background: Cisplatin (CP) is an extremely effective anticancer agent widely used to treat various cancer types, however, the potential side effects include testicular dysfunction. This study was to investigate, using a rat model of CP-induced testicular dysfunction, the protective effects of relaxin (RLN) against oxidative stress, testicular function, histological damage, spermatogenesis, germ-cell apoptosis, and sperm output, and to explore the usefulness of RLN as a potential protective drug for use with CP in chemotherapeutic treatments.

Methods: Sprague-Dawley male rats were used, which were divided into three groups: sham control, CP, and CP + RLN. Read More

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http://dx.doi.org/10.1186/s12610-020-0101-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061478PMC

Correction to: Gel electrophoresis of human sperm: a simple method for evaluating sperm protein quality.

Basic Clin Androl 2020;30. Epub 2020 Feb 13.

1EA 4308 - GQG - Gametogenesis and gamete quality, University of Lille, F-59000 Lille, France.

[This corrects the article DOI: 10.1186/s12610-018-0076-0.]. Read More

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http://dx.doi.org/10.1186/s12610-020-00102-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017460PMC
February 2020

RISUG as a male contraceptive: journey from bench to bedside.

Basic Clin Androl 2020 13;30. Epub 2020 Feb 13.

Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, 302004 India.

Even after decades of research men still lack reliable and reversible contraceptive methods comparable to female methods of contraception. Traditional methods of male contraception present a high failure rate and also involve high risk both when used for contraception and for protection against sexually transmitted diseases. Various chemical, hormonal, immunological, vas based and herbal methods of contraception have been examined by scientists world over during the past four decades. Read More

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http://dx.doi.org/10.1186/s12610-020-0099-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017607PMC
February 2020

The detection of canine anti-sperm antibody following parenteral immunization of bitches against homogenized whole sperm.

Basic Clin Androl 2020 23;30. Epub 2020 Jan 23.

2Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Fars Iran.

Backgrounds: The development of a canine-specific method of immunocontraception is one of the non-invasive controlling strategies for humanely decreasing the dog population. This study was aimed to investigate the potential of whole sperm in stimulating the immune system and producing specific anti-sperm antibodies (ASAs) in female dogs. Mature, mixed-breed bitches were subcutaneously immunized with high (200 × 10 cells/mL) and low (100 × 10 cells/mL) doses of sperm vaccine, emulsified with Freund's adjuvants. Read More

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http://dx.doi.org/10.1186/s12610-020-0100-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977277PMC
January 2020

Testicular expression of long non-coding RNAs is affected by curative GnRHa treatment of cryptorchidism.

Basic Clin Androl 2019 27;29:18. Epub 2019 Dec 27.

4Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

Background: Cryptorchidism is a frequent endocrinopathy in boys that has been associated with an increased risk of developing testicular cancer and infertility. The condition is curable by combined surgery and hormonal treatment during early pre-pubertal stages using gonadotropin releasing hormone agonist (GnRHa). However, whether the treatment also alters the expression of testicular long non-coding RNAs (lncRNAs) is unknown. Read More

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http://dx.doi.org/10.1186/s12610-019-0097-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933710PMC
December 2019

Can the SCD test and terminal uridine nick-end labeling by flow cytometry technique (TUNEL/FCM) be used interchangeably to measure sperm DNA damage in routine laboratory practice?

Basic Clin Androl 2019 26;29:17. Epub 2019 Dec 26.

1Assistance Médicale à la Procréation, CECOS, Pôle Femme et Enfant, CHU Estaing, Clermont-Ferrand, France.

Background: Numerous tests have been proposed to evaluate sperm DNA integrity. To assess the sperm chromatin dispersion (SCD) test in an andrology laboratory, twenty-five men attending Clermont-Ferrand (France) University Hospital's Center for Reproductive Medicine were recruited. Sperm DNA damage was measured in the same semen samples using the SCD test and the Terminal Uridine Nick-end Labeling by flow cytometry technique (TUNEL/FCM) after density gradient centrifugation. Read More

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http://dx.doi.org/10.1186/s12610-019-0098-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933933PMC
December 2019

Colibri® insecticide induces male reproductive toxicity: alleviating effects of (Anacardiaceae) in rats.

Basic Clin Androl 2019 20;29:16. Epub 2019 Dec 20.

1Animal Physiology and Phytopharmacology Laboratory, Faculty of Science, University of Dschang, PO Box: 67, Dschang, Cameroon.

Background: Imidacloprid, a neonicotinoid insecticide, has been associated to severe reproductive toxicity in mammals. Although some preventive measures have been reported, curative strategies are yet to be explored. The present study was designed to investigate the alleviating effects of on the reproductive toxicity of colibri®, a commercial formulation of imidacloprid, in adult male rats. Read More

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http://dx.doi.org/10.1186/s12610-019-0096-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924042PMC
December 2019

Sleep related painful erection: an algorithm for evaluation and management.

Basic Clin Androl 2019 4;29:15. Epub 2019 Dec 4.

Groupe hospitalier Diaconesses - Croix Saint Simon, Paris- France, 5 quai bucherelle, 95300 Pontoise, France.

Background: Sleep related painful erection (SRPE) is a rare parasomnia consisting of nocturnal penile tumescence accompanied by pain that awakens the individual. Normal non-painful erections are experienced when awake. No penile anatomic abnormalities are present. Read More

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http://dx.doi.org/10.1186/s12610-019-0095-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894200PMC
December 2019

Oxidative-antioxidative status and hepatic and renal factors following melatonin administration in castrated and intact dogs.

Basic Clin Androl 2019 15;29:14. Epub 2019 Nov 15.

Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, P.O.Box 71441-69155, Shiraz, Iran.

Backgrounds: Melatonin has significant antioxidant and hepatoprotective effects in normal and oxidative stress conditions. The aim of the present study was to assess the effects of melatonin on antioxidant, hepatic, and renal factors in intact and castrated dogs. Twenty male mixed-breed adult dogs were aligned in an experimental randomized and controlled trial. Read More

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http://dx.doi.org/10.1186/s12610-019-0094-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858660PMC
November 2019

Chemical sterilization with intratesticular administration of zinc gluconate in adult dogs: a preliminary report.

Basic Clin Androl 2019 1;29:12. Epub 2019 Aug 1.

Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, P.O.Box 71441-69155, Shiraz, Fars Iran.

Background: Chemical sterilization with zinc gluconate is being developed due to its permanent contraceptive effect in prepubertal dogs. In this study, five healthy adult dogs were selected randomly. Semen samples were collected and analyzed before the study to confirm normal testicular function. Read More

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http://dx.doi.org/10.1186/s12610-019-0092-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670226PMC

Step-by-step loupes-mTESE in non-obstructive azoospermic men, a retrospective study.

Basic Clin Androl 2019 15;29:11. Epub 2019 Jul 15.

CPSR, department of AMP, Clinique Les Jasmins, Tunis, Tunisia.

Background: Men with non-obstructive azoospermia (NOA) may have sperm in their testes and a procedure of sperm retrieval and assisted reproduction is required in them to allow fertility. Standard procedures such as fine needle aspiration (FNA) and conventional testicular sperm extraction (cTESE) harvest random samples with a sperm retrieval rate (SRR) of 45%. Microdissection testicular sperm extraction (mTESE) is nowadays considered to be the most accurate technique to retrieve sperm in men with NOA. Read More

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http://dx.doi.org/10.1186/s12610-019-0091-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628476PMC
July 2019
2 Reads

Metabolic syndrome and smoking are independent risk factors of male idiopathic infertility.

Basic Clin Androl 2019 1;29. Epub 2019 Jul 1.

1Sorbonne Université, Saint Antoine Research center, INSERM équipe Lipodystrophies génétiques et acquisesService de biologie de la reproduction-CECOS, AP-H, Hôpital Tenon, 4 rue de la Chine, 75020 Paris, France.

Background: Overweight and obesity are known to impact male fertility and are commonly associated with abdominal obesity and metabolic disorders. The association between abdominal obesity or metabolic syndrome with male reproduction has not been fully investigated. Moreover, many factors may interfere with the evaluation of the impact of metabolic syndrome on male fertility. Read More

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http://dx.doi.org/10.1186/s12610-019-0090-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600889PMC
July 2019
2 Reads

Genes located in Y-chromosomal regions important for male fertility show altered transcript levels in cryptorchidism and respond to curative hormone treatment.

Basic Clin Androl 2019 3;29. Epub 2019 Jun 3.

Cryptorchidism Research Institute, Kindermedizinisches Zentrum Liestal, 4410 Liestal, Switzerland.

Background: Undescended (cryptorchid) testes in patients with defective mini-puberty and low testosterone levels contain gonocytes that fail to differentiate normally, which impairs the development of Ad spermatogonia and ultimately leads to adult infertility. Treatment with the gonadotropin-releasing hormone agonist GnRHa increases luteinizing hormone and testosterone and rescues fertility in the majority of pathological cryptorchid testes. Several Y-chromosomal genes in the male-specific Y region (MSY) are essential for spermatogenesis, testis development and function, and are associated with azoospermia, infertility and cryptorchidism. Read More

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http://dx.doi.org/10.1186/s12610-019-0089-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545630PMC
June 2019
17 Reads

Two cases of male patients followed for a classical form of congenital adrenal hyperplasia (CAH), presenting an azoospermia: analysis and review of the literature.

Basic Clin Androl 2019 12;29:10. Epub 2019 Mar 12.

1Department of Gynecology-Obstetrics, Archet 2 Hospital, 151 route Sainte-Antoine de Ginestière CS 23079, 06202 Nice, Cedex 3 France.

Background: Congenital hyperplasia of the adrenal glands is a rare pathology, which can have an impact on male fertility. We report 2 cases of azoospermia in patients followed for a classical form of congenital adrenal hyperplasia.

Cases Presentation: 1st case: After 18 months of infertility of the couple, explorations showed a high level of ACTH on the hormonal biological analysis. Read More

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http://dx.doi.org/10.1186/s12610-019-0084-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532123PMC
March 2019
6 Reads

Semen and male genital tract characteristics of patients with Fabry disease: the FERTIFABRY multicentre observational study.

Basic Clin Androl 2019 15;29. Epub 2019 May 15.

11Medical Genetics Departement, CHU de Bordeaux, INSERM U1211, F-33076 Bordeaux Cedex, France.

Background: Fabry disease (FD) is a rare disorder caused by the deficient activity of α-galactosidase A (α-Gal A). This enzymatic deficit results in the cellular accumulation of globotriaosylceramide (GL-3 or Gb) and related glycosphingolipids in practically all organs and tissues in the body. The identification of deposits of Gb at the reproductive tract level suggests that this part of the body might be involved. Read More

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http://dx.doi.org/10.1186/s12610-019-0088-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518714PMC
May 2019
7 Reads

Obesity related metabolic endotoxemia is associated with oxidative stress and impaired sperm DNA integrity.

Basic Clin Androl 2019 13;29. Epub 2019 May 13.

1School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, South Australia 5001 Australia.

Background: Obesity is known to be associated with inflammation, oxidative stress and a resulting reduction in sperm DNA integrity. Importantly, obesity is also reported to be associated with an increase in intestinal permeability with the passage of intestinal bacteria into the circulation (metabolic endotoxemia) that triggers a systemic state of inflammation and resultant oxidative stress. Therefore, we hypothesised that this obesity related increase in intestinal permeability and resultant metabolic endotoxemia (ME) may activate inflammation within the male reproductive tract, leading to increased reactive oxygen species production, sperm oxidative stress and a decline in DNA integrity. Read More

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http://dx.doi.org/10.1186/s12610-019-0087-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513521PMC
May 2019
2 Reads

Genetic defects in human azoospermia.

Basic Clin Androl 2019 23;29. Epub 2019 Apr 23.

1EA7404-GIG, UFR des Sciences de la Santé Simone Veil, UVSQ, Montigny le Bretonneux, France.

As with many other diseases, genetic testing in human azoospermia was initially restricted to karyotype analyses (leading to diagnostic chromosome rearrangement tests for Klinefelter and other syndromes). With the advent of molecular biology in the 1980s, genetic screening was broadened to analyses of Y chromosome microdeletions and the gene coding for the cystic fibrosis transmembrane conductance regulator (). Decades later, the emergence of whole-genome techniques has led to the identification of other genetic defects associated with human azoospermia. Read More

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http://dx.doi.org/10.1186/s12610-019-0086-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477738PMC
April 2019
2 Reads

Testosterone replacement therapy and the risk of adverse cardiovascular outcomes and mortality.

Basic Clin Androl 2019 29;29. Epub 2019 Mar 29.

3Quantitative Health Sciences, Cleveland Clinic, Desk JJN3, Cleveland, Ohio 44195 USA.

Background: The risk of adverse cardiovascular events and mortality associated with testosterone replacement therapy is controversial. The purpose of this report was to evaluate the effect of testosterone replacement therapy (TRT) in men with secondary hypogonadism on the risk of myocardial infarction (MI), stroke (CVA) or all-cause mortality.

Methods: A retrospective cohort study was conducted using the Cleveland Clinic's electronic health record. Read More

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http://dx.doi.org/10.1186/s12610-019-0085-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440106PMC
March 2019
17 Reads

Genetic causes of male infertility: snapshot on morphological abnormalities of the sperm flagellum.

Basic Clin Androl 2019 4;29. Epub 2019 Mar 4.

1INSERMU1016, CNRS UMR8104, Université Paris Descartes, 75014 Paris, France.

Male infertility due to Multiple Morphological Abnormalities of the sperm Flagella (MMAF), is characterized by nearly total asthenozoospermia due to the presence of a mosaic of sperm flagellar anomalies, which corresponds to short, angulated, absent flagella and flagella of irregular calibre. In the last four years, 7 novel genes whose mutations account for 45% of a cohort of 78 MMAF individuals were identified: , , , , , . This successful outcome results from the efficient combination of high-throughput sequencing technologies together with robust and complementary approaches for functional validation, in vitro, and in vivo using the mouse and unicellular model organisms such as the flagellated parasite . Read More

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http://dx.doi.org/10.1186/s12610-019-0083-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398242PMC
March 2019
20 Reads

Protective role of N-acetylcysteine (NAC) on human sperm exposed to etoposide.

Basic Clin Androl 2019 7;29. Epub 2019 Feb 7.

1Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

Background: Although recent progress in cancer treatment has increased patient survival and improved quality of life, reproductive side effects are still for concern. One way to decrease gonadal impairment is to use cytoprotectors. In testicular cancer, etoposide is generally used in combination with other agents, but there are no in-vitro studies of sperm exposure to etoposide and cytoprotectors, namely N-acetylcysteine (NAC). Read More

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http://dx.doi.org/10.1186/s12610-018-0082-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366041PMC
February 2019
2 Reads

Penile Lymphangioma: review of the literature with a case presentation.

Basic Clin Androl 2019 28;29. Epub 2019 Jan 28.

3Department of Vattikuti Urology Institute, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 USA.

Background: Penile lymphangiomas are rare manifestations of lymphangiomas or lymphatic malformations which are more commonly found in the head or neck region of the body. Lymphangiomas are further categorized as lymphangioma circumscriptum, cavernous lymphangioma, cystic hygroma, or acquired lymphangiomas (also known as lymphangiectasia), based on their depth and etiology.

Results: A literature review revealed only 30 cases of penile lymphangioma between 1947 and March 30, 2018. Read More

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http://dx.doi.org/10.1186/s12610-018-0081-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348653PMC
January 2019
10 Reads

The 100 most influential manuscripts in andrology: a bibliometric analysis.

Basic Clin Androl 2018 12;28:15. Epub 2018 Dec 12.

2Department of Urology, Cwm Taf University Health Board, Royal Glamorgan Hospital, Llantrisant, CF72 8XR UK.

Background: As the specialty of Andrology expands it is important to establish the most important studies that have shaped, and continue to shape, current research and clinical practice. Bibliometric analysis involving a citation rank list is an established means by which to identify the published material within a given field that has greatest intellectual influence. This bibliometric analysis sought to identify the 100 most influential manuscripts in Andrology, as well as the key research themes that have shaped contemporary understanding and management of andrological conditions. Read More

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https://bacandrology.biomedcentral.com/articles/10.1186/s126
Publisher Site
http://dx.doi.org/10.1186/s12610-018-0080-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290538PMC
December 2018
24 Reads

Effects of lipopolysaccharide-induced inflammation on hypoxia and inflammatory gene expression pathways of the rat testis.

Basic Clin Androl 2018 16;28:14. Epub 2018 Nov 16.

Monmouth University, 400 Cedar Avenue, West Long Branch, NJ 07764 USA.

Background: Bacterial infection and inflammation of the testis impairs fertility, yet an understanding of inflammatory responses of the testis is incomplete. We are interested in identifying gene pathways involved in the detection and clearance of infectious microbes in the male reproductive tract. In previous studies in our lab focused on hypoxia-responsive genes of the testis, preliminary experiments suggested that genes classically categorized as hypoxia genes are also activated during antimicrobial responses. Read More

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http://dx.doi.org/10.1186/s12610-018-0079-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238406PMC
November 2018
4 Reads

Epididymal approaches to male contraception.

Authors:
Joël R Drevet

Basic Clin Androl 2018 6;28:12. Epub 2018 Nov 6.

Laboratoire GReD "Génétique, Reproduction & Développement", UMR CNRS 6293, INSERM U1103, Université Clermont Auvergne (UCA), 28-Place Henri Dunant, bâtiment CRBC, 63000 Clermont-Ferrand, France.

Today, a vast arsenal of contraceptive methods interfering at different levels of the female reproductive axis is available. This is not the case for men for whom, until now, there is no reliable male reversible method and for whom vasectomy, condom and withdrawal are the only options available. Despite this limited supply, more than one third of all contraceptive methods used worldwide rely on the cooperation of the male partner. Read More

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http://dx.doi.org/10.1186/s12610-018-0078-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219163PMC
November 2018
24 Reads

Male reproductive health statement (XIIIth international symposium on Spermatology, may 9th-12th 2018, Stockholm, Sweden.

Basic Clin Androl 2018 29;28:13. Epub 2018 Oct 29.

22GReD Laboratory INSERM U1103 - CNRS UMR6293, Faculty de Medicine, CRBC, Université Clermont Auvergne (UCA), 63000 Clermont-Ferrand, France.

On the occasion of the held from 9 to 13 May 2018 in Stockholm (Sweden), participants (guest speakers and audience) collectively felt the need to make a public statement on the general issue of male reproductive health. Our intention is to raise awareness of what we believe is a neglected area of research despite alarming situations around the world. The disclosure strategy desired by the co-authors is to bring it to the attention of the greatest number partly by considering co-publication in the various periodicals dealing with Reproductive Biology and Andrology. Read More

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https://bacandrology.biomedcentral.com/articles/10.1186/s126
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http://dx.doi.org/10.1186/s12610-018-0077-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205799PMC
October 2018
63 Reads

Gel electrophoresis of human sperm: a simple method for evaluating sperm protein quality.

Basic Clin Androl 2018 3;28:10. Epub 2018 Sep 3.

1EA 4308 - GQG - Gametogenesis and gamete quality, University of Lille, F-59000 Lille, France.

Background: The limitations of conventional sperm analyses have highlighted the need for additional means of evaluating sperm quality.

Methods: In a study of a cohort of 245 men with known conventional sperm parameters, one-dimensional PAGE was used to monitor protein content and quality in samples from individual ejaculates.

Results: The sperm protein content varied markedly from sample to another, especially in the high-molecular-weight range. Read More

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https://bacandrology.biomedcentral.com/articles/10.1186/s126
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http://dx.doi.org/10.1186/s12610-018-0076-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120067PMC
September 2018
34 Reads

Sperm cryopreservation incidence in men with testicular cancer: towards a stabilization in testicular cancer incidence? Results from the CECOS network.

Basic Clin Androl 2018 3;28:11. Epub 2018 Aug 3.

Université de Toulouse, UPS, Groupe de Recherche en Fertilité Humaine (EA 3694, Human Fertility Research Group), TSA 70034, 31059 Toulouse Cedex 9, France.

Background: Testicular cancer (TC) represents 1% of all new male cancer cases but remains the most frequent cancer in adolescents and young adults in industrialized countries. In this study, we assessed time trends in use of sperm cryopreservation by men with TC from 1990 to 2013 in France.

Methods: We collected data from patients diagnosed with TC who underwent sperm cryopreservation in the French national network of sperm banks. Read More

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http://dx.doi.org/10.1186/s12610-018-0075-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091093PMC
August 2018
22 Reads

A change from gonadotropin releasing hormone antagonist to gonadotropin releasing hormone agonist therapy does not affect the oncological outcomes in hormone sensitive prostate cancer.

Basic Clin Androl 2018 18;28. Epub 2018 Jul 18.

1Department of Urology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585 Japan.

Background: The aim of our retrospective study was to evaluate the 5-year survival and time to castration resistant prostate cancer in patients with hormone sensitive prostate cancer treated with the gonadotropin releasing hormone antagonist, degarelix. Another aim was to evaluate the effects of changing the treatment from degarelix to a gonadotropin releasing hormone agonist after achieving stable disease control, on the clinical and oncological outcomes.

Results: Our analysis was based on the data of 108 patients with prostate cancer who were treated with degarelix. Read More

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http://dx.doi.org/10.1186/s12610-018-0074-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050721PMC
July 2018
2 Reads

Testicular microlithiasis and testicular tumor: a review of the literature.

Basic Clin Androl 2018 9;28. Epub 2018 Jul 9.

1Department of Urology, CHRU Nancy, Nancy, France.

Introduction: There are numerous scientific publications on testicular microlithiasis (TML) detected during ultrasound (US) examination. We wished to update the data.

Methods: PubMed was used to identify original articles published between 1998 and May 2017 describing the association between TML and testicular tumor. Read More

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https://bacandrology.biomedcentral.com/articles/10.1186/s126
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http://dx.doi.org/10.1186/s12610-018-0073-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036676PMC
July 2018
23 Reads

The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review.

Basic Clin Androl 2018 20;28. Epub 2018 Jun 20.

1Aix Marseille Univ, Inserm, MMG, U1251, Marseille Medical Genetics, 13385 Marseille, France.

The nuclear lamina (NL) is a filamentous protein meshwork, composed essentially of lamins, situated between the inner nuclear membrane and the chromatin. The NL is a component of the nuclear envelope, interacts with a wide range of proteins and is required for normal nuclear structure and physiological development. During spermiogenesis the spermatid nucleus is elongated, and dramatically reduced in size with protamines replacing histones to produce a highly compacted chromatin. Read More

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http://dx.doi.org/10.1186/s12610-018-0072-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008938PMC
June 2018
4 Reads

Understanding the seminal plasma proteome and its role in male fertility.

Basic Clin Androl 2018 4;28. Epub 2018 Jun 4.

1Department of Surgery, Division of Urology, Universidade Federal de São Paulo, R Embau, 231, Sao Paulo, SP 04039-060 Brazil.

Seminal plasma is a complex fluid comprised of secretions from the seminal vesicles, the prostate, bulbourethral glands and from the seminiferous tubule lumen / epididymides / . While it has been established that seminal plasma serves not only as a medium to carry, protect, and nourish sperm after ejaculation up to fertilization, but also as a functional modulator of sperm function, there is still a need to properly characterize the molecular make-up of seminal plasma in fertile men, and to understand how this is altered in different causes of male infertility. The main purpose of this manuscript was to review articles that studied the human seminal plasma proteome, ranging from characterizing a fertile seminal plasma proteomic map to studies comparing seminal plasma from fertile and infertile men, and comparing seminal plasma of fertile or normozoospermic men to a diverse range of biological causes for male infertility. Read More

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http://dx.doi.org/10.1186/s12610-018-0071-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985566PMC
June 2018
20 Reads

Is sperm FISH analysis still useful for Robertsonian translocations? Meiotic analysis for 23 patients and review of the literature.

Basic Clin Androl 2018 7;28. Epub 2018 May 7.

CHU de Grenoble, UF de Biologie de la procréation, F-38000 Grenoble, France.

Background: Robertsonian translocations (RobT) are common structural chromosome rearrangements where carriers display a majority of chromosomally balanced spermatozoa from alternate segregation mode. According to some monotony observed in the rates of balanced segregation, is sperm FISH analysis obsolete for RobT carriers?

Methods: Retrospective cohort research study on 23 patients analyzed in our center from 2003 to 2017 and compared to the data of 187 patients in literature from 1983 to 2017.Robertsonian translocation carriers were divided in six groups according to the chromosomes involved in the translocation: 9 patients from our center and 107 from literature carrying 45,XY,der(13;14) karyotype, 3 and 35 patients respectively with 45,XY,der(14;21), 5 and 11 patients respectively with 45,XY,der(13;15), 4 and 7 patients respectively with 45,XY,der(14;15), 1 and 4 patients respectively with 45,XY,der(13;22),and 1 and 10 patients respectively with 45,XY,der(14;22). Read More

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http://dx.doi.org/10.1186/s12610-018-0069-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937048PMC
May 2018
27 Reads

Sperm aneuploidy and DNA fragmentation in unexplained recurrent pregnancy loss: a multicenter case-control study.

Basic Clin Androl 2018 2;28. Epub 2018 Apr 2.

1Research Group on Human Fertility EA 3694, University Paul Sabatier Toulouse III, 330 av Grande Bretagne, 31059 Toulouse, France.

Background: Recurrent pregnancy loss (RPL) is defined as the loss of at least three pregnancies in the first trimester. Although the most common cause is embryo aneuploidy, and despite female checkup and couple karyotyping, in about 50% of cases RPL remain unexplained. Male implication has little been investigated and results are discordant. Read More

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http://dx.doi.org/10.1186/s12610-018-0070-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879915PMC
April 2018
7 Reads

Longer trinucleotide repeats of androgen receptor are associated with higher testosterone and low oxytocin levels in diabetic premature ejaculatory dysfunction patients.

Basic Clin Androl 2018 6;28. Epub 2018 Mar 6.

7Department of Medical Biochemistry, Ege University School of Medicine, Bornova, Izmir Turkey.

Background: Despite its worldwide high occurrence, the obscurity regarding the description, epidemiology and management of premature ejaculation remains provocative. It is well established that male premature ejaculatory dysfunction is an increasing problem due to spontaneous ejaculation across a variety of general and clinical subjects. The main goal of this study was to determine the relationships between trinucleotide repeats of the androgen receptor (AR), sex steroids, and pituitary hormones with sexual function in men with type 2 diabetes mellitus (DM) and reported with acquired premature ejaculation (PE). Read More

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http://dx.doi.org/10.1186/s12610-018-0068-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838858PMC
March 2018
20 Reads

Curative GnRHa treatment has an unexpected repressive effect on Sertoli cell specific genes.

Basic Clin Androl 2018 9;28. Epub 2018 Feb 9.

Cryptorchidism Research Institute, Kindermedizinisches Zentrum Liestal, 4410 Liestal, Switzerland.

Background: Follicle stimulating hormone and testosterone stimulate Sertoli cells to support germ cell function and differentiation. During mini-puberty, when gonadotropin (GnRH) stimulates increases in plasma luteinizing hormone (LH) and testosterone levels, gonocytes are transformed into Ad spermatogonia. In cryptorchidism, impaired gonadotropin secretion during mini-puberty results in insufficient LH and testosterone secretion, impaired gonocyte transition to Ad spermatogonia, and perturbed Sertoli cell proliferation. Read More

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http://dx.doi.org/10.1186/s12610-018-0067-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806254PMC
February 2018
23 Reads

Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report.

Basic Clin Androl 2018 25;28. Epub 2018 Jan 25.

1Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562 Japan.

Background: Although oncologic testicular sperm extraction (onco-TESE) has been increasingly practiced, the evidence of onco-TESE performed in patients with testicular cancer is insufficient. Furthermore, in bilateral testicular cancer, accounting for 0.5%-1% of testicular cancers, onco-TESE is more challenging and has been insufficiently reported. Read More

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http://dx.doi.org/10.1186/s12610-018-0066-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785797PMC
January 2018
64 Reads

On the descent of the epididymo-testicular unit, cryptorchidism, and prevention of infertility.

Basic Clin Androl 2017 14;27:21. Epub 2017 Nov 14.

Cryptorchidism Research Institute, Kindermedizinisches Zentrum Liestal, Liestal, Switzerland.

This comprehensive review provides in-depth coverage of progress made in understanding the molecular mechanisms underlying cryptorchidism, a frequent pathology first described in about 1786 by John Hunter. The first part focuses on the physiology, embryology, and histology of epididymo-testicular descent. In the last 20 years epididymo-testicular descent has become the victim of schematic drawings with an unjustified rejection of valid histological data. Read More

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https://bacandrology.biomedcentral.com/articles/10.1186/s126
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http://dx.doi.org/10.1186/s12610-017-0065-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686796PMC
November 2017
6 Reads

Paternal obesity: how bad is it for sperm quality and progeny health?

Basic Clin Androl 2017 26;27:20. Epub 2017 Oct 26.

Université Cote d'Azur, Inserm, C3M (team 10), Nice, France.

There is substantial evidence that paternal obesity is associated not only with an increased incidence of infertility, but also with an increased risk of metabolic disturbance in adult offspring. Apparently, several mechanisms may contribute to the sperm quality alterations associated with paternal obesity, such as physiological/hormonal alterations, oxidative stress, and epigenetic alterations. Along these lines, modifications of hormonal profiles namely reduced androgen levels and elevated estrogen levels, were found associated with lower sperm concentration and seminal volume. Read More

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http://dx.doi.org/10.1186/s12610-017-0064-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657098PMC
October 2017
4 Reads

Occurrence and reproductive roles of hormones in seminal plasma.

Basic Clin Androl 2017 8;27:19. Epub 2017 Sep 8.

Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic.

Only 2-5% of seminal fluid is composed of spermatozoa, while the rest is seminal plasma. The seminal plasma is a rich cocktail of organic and inorganic compounds including hormones, serving as a source of nutrients for sperm development and maturation, protecting them from infection and enabling them to overcome the immunological and chemical environment of the female reproductive tract. In this review, a survey of the hormones found in human seminal plasma, with particular emphasis on reproductive hormones is provided. Read More

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http://dx.doi.org/10.1186/s12610-017-0062-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640966PMC
September 2017
7 Reads

ICSI diagnostic: a way to prevent total fertilization failure after 4 unsuccessful IUI.

Basic Clin Androl 2017 21;27:18. Epub 2017 Sep 21.

A.R.T medical Team of C.H.C. St Vincent, 4000 Rocourt, Belgium.

Background: The aim of this retrospective study is to investigate the relevance of dividing oocytes and using some for traditional in vitro fertilization (IVF) and others for intracytoplasmic sperm injection (ICSI) as of the first IVF cycle in patients with unexplained infertility who have undergone 4 intrauterine insemination (IUI) cycles which produced no pregnancies.

Methods: This retrospective study includes patients with unexplained infertility who have failed to become pregnant, after 4 IUI, despite normal semen parameters after sperm capacitation. These women were treated in our assisted fertilization program from 2008 until 2015. Read More

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http://dx.doi.org/10.1186/s12610-017-0061-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612332PMC
September 2017
40 Reads

Patterns of residual HIV-1 RNA shedding in the seminal plasma of patients on effective antiretroviral therapy.

Basic Clin Androl 2017 8;27:17. Epub 2017 Sep 8.

Université de Toulouse, UPS, Groupe de Recherche en Fertilité Humaine (EA 3694, Human Fertility Research Group), Toulouse, France.

Background: More and more HIV-1-infected men on effective antiretroviral treatment (ART) have unprotected sex in order to procreate. The main factor influencing transmission is seminal HIV shedding. While the risk of HIV transmission is very low, it is difficult to assess in individuals. Read More

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http://dx.doi.org/10.1186/s12610-017-0063-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590187PMC
September 2017
11 Reads

Sleep disturbances and semen quality in an Italian cross sectional study.

Basic Clin Androl 2017 21;27:16. Epub 2017 Aug 21.

Dipartimento della Donna, del Neonato e del Bambino, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Commenda 12, 20122 Milano, Italy.

Introduction: In order to obtain information about the relationship between sleep disturbances and sperm parameters, we analyzed data from a study conducted in a Italian Fertility Clinic, in men of couples seeking help for infertility.

Patients And Methods: Male partners with or without a medical history of reproductive organ diseases (cryptorchidism, varicocele, orchitis, testicular torsion) were eligible for the study. There were 382 men evaluated from May 2014 to November 2016, all of whom completed a self-administered questionnaire on general lifestyle habits. Read More

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http://dx.doi.org/10.1186/s12610-017-0060-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563907PMC
August 2017
13 Reads

Relationship between Semenogelins bound to human sperm and other semen parameters and pregnancy outcomes.

Basic Clin Androl 2017 8;27:15. Epub 2017 Aug 8.

Center for IVF and Infertility, International University of Health and Welfare Hospital, Nasushiobara, Japan.

Background: Semenogelins (SEMGs) are major components of human seminal vesicle secretions. Due to SEMG's sperm-motility inhibitor, a significant negative correlation between sperm motility and the proportion of SEMG-bound spermatozoa (SEMG+) was found in asthenozoospermic patients. SEMGs also show intrinsic inhibitory capability for sperm capacitation; however, studies on actual clinical specimens have not been conducted. Read More

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http://dx.doi.org/10.1186/s12610-017-0059-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547539PMC
August 2017
24 Reads

Association of admission testosterone level with ST-segment resolution in male patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.

Basic Clin Androl 2017 21;27:14. Epub 2017 Jul 21.

Cardiology Department, Cardiovascular Research Center, Tabriz University of Medical science, Madani Heart Center, Daneshgah Ave, Tabriz, Iran.

Background: Low level of testosterone may be associated with cardiovascular diseases in men, as some evidence suggests a protective role for testosterone in cardiovascular system. Little is known about the possible role of serum testosterone in response to reperfusion therapy in ST-elevation myocardial infarction (STEMI) and its relationship with ST-segment recovery. The present study was conducted to evaluate the association of serum testosterone levels with ST-segment resolution following primary percutaneous coronary intervention (PPCI) in male patients with acute STEMI. Read More

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http://dx.doi.org/10.1186/s12610-017-0058-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532774PMC
July 2017
51 Reads

Hypogonadotropic hypogonadism in men with hereditary hemochromatosis.

Basic Clin Androl 2017 8;27:13. Epub 2017 Jul 8.

Laboratoire de Biologie de la Reproduction, CECOS Lorraine, CHU Nancy, Nancy, France.

Hereditary hemochromatosis is a genetic disease that progresses silently. This disease is often diagnosed late when complications appear. Hypogonadotropic hypogonadism (HH) is one of the classical complications of hemochromatosis. Read More

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http://dx.doi.org/10.1186/s12610-017-0057-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501943PMC
July 2017
12 Reads

Does sperm quality and DNA integrity differ in cryopreserved semen samples from young, adult, and aged Nellore bulls?

Basic Clin Androl 2017 21;27:12. Epub 2017 Jun 21.

FMVA, Faculty of Veterinary Medicine, UNESP - Univ Estadual Paulista, São José do Rio Preto, Brazil.

Background: In humans, it is now well documented that rising paternal age is correlated with decreased sperm DNA integrity and embryonic developmental failures. On the other side of the coin, it is also reported that very young fathers such as teenagers carry an increased risk of adverse birth outcomes. These observations suggest that, at least in humans, there is an age window for optimal sperm DNA integrity. Read More

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http://dx.doi.org/10.1186/s12610-017-0056-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479005PMC
June 2017
6 Reads