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Methods Mol Biol 2022 ;2394:867-882

Ob/Gyn and Women's Health Institute, Cleveland Clinic, Cleveland, OH, USA.

Cervical cancer is a leading cause of mortality for women in low- and middle-income countries (LMICs). Invasive disease can be prevented through the treatment of high-grade cervical precancer lesions. Types of treatment for cervical precancer include excisional procedures that surgically remove the affected tissue and ablation treatments which utilize extreme temperatures to destroy precancerous cells. Read More

Elife 2022 01 18;11. Epub 2022 Jan 18.

Regenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, Department of Surgery, David Geffen School of Medicine, Los Angeles, United States.

Attempts to minimize scarring remain among the most difficult challenges facing surgeons, despite the use of optimal wound closure techniques. Previously, we reported improved healing of dermal excisional wounds in circadian clock neuronal PAS domain 2 ()-null mice. In this study, we performed high-throughput drug screening to identify a compound that downregulates activity. Read More

Biomolecules 2021 10 19;11(10). Epub 2021 Oct 19.

Department of Dentistry, Orthodontics and Craniofacial Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, 6525EX Nijmegen, The Netherlands.

This study aimed to analyze the effects of fibrin constructs enhanced with laminin-nidogen, implanted in the wounded rat soft palate. Fibrin constructs with and without laminin-nidogen were implanted in 1 mm excisional wounds in the soft palate of 9-week-old rats and compared with the wounded soft palate without implantation. Collagen deposition and myofiber formation were analyzed at days 3, 7, 28 and 56 after wounding by histochemistry. Read More

Afr J Paediatr Surg 2021 Oct-Dec;18(4):205-209

Department of Pathology, Faculty of Basic Clinical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria.

Background: A neck mass is any abnormal lesion in the neck that can be seen, palpated, or identified on imaging. It is one of the most common reasons for presentation to the surgical clinics.

Aim: the aim is to analyse the clinical presentation and treatment outcome in children who were diagnosed and managed for neck masses in a tertiary centre in Northwestern Nigeria. Read More

ACS Biomater Sci Eng 2021 06 21;7(6):2649-2660. Epub 2021 May 21.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, One Shields Avenue, Davis, California 95616, United States.

Re-epithelialization of wounds is a critical element of wound closure. Growth factors have been used in combination with conventional wound management to promote closure, but the method of delivery has been limited to the topical application of ointment formulations. Cytoactive factors delivered in this way have short resident times in wounds and have met with limited success. Read More

Am J Dermatopathol 2021 Dec;43(12):e254-e258

Dermatology Section, Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Roanoke, VA.

Abstract: Oncocytomas are benign neoplasms that are most often found in the salivary glands and kidneys. Ocular oncocytoma typically present as an asymptomatic dark blue papule on the lacrimal caruncle. Histologically, the tumor is composed of oncocytes, cells notable for eosinophilic cytoplasmic granules representing large quantities of dysfunctional mitochondria. Read More

Pan Afr Med J 2021 15;38:40. Epub 2021 Jan 15.

Department of OBGYN, Faculty of Clinical Sciences, College of Health Sciences, University of Jos, Jos, Plateau State, Nigeria.

Introduction: head and neck cancers have essentially been a disease of the elderly but recent studies are beginning to demonstrate their increasing incidence in young people with infections such as human papilloma virus (HPV). This study was carried out to determine the prevalence of high risk Human papilloma virus (hrHPV) related oropharyngeal carcinoma and its prevalent genotypes as well as their strength of association with HIV in adult Nigerian subjects.

Methods: this was a cross-sectional study of 41 patients with oropharyngeal carcinomas seen over a 2-year period. Read More

Arch Dermatol Res 2021 Nov 12;313(9):793-797. Epub 2021 Jan 12.

Departments of Dermatology, Otolaryngology and Surgery, Feinberg School of Medicine, Northwestern University, 676 N St Clair Suite 1600, Chicago, IL, 60611, USA.

Since dermatologists routinely perform surgery in an outpatient setting, ensuring that dermatology trainees are provided with opportunities to develop sufficient proficiency in excisional surgery and suture technique is paramount. The objectives of this study are to assess trainee preference for silicone-based synthetic skin compared with porcine skin as a surgical training medium and to assess the ability of trainees to successfully demonstrate basic surgical skills using the simulated skin model. Participants were a convenience sample of dermatology residents from the greater Chicago area, who were asked to perform an elliptical excision and bilayered repair on a silicone-based synthetic skin model. Read More

J Obstet Gynaecol Can 2020 Oct 28;42(10):1211-1216. Epub 2020 Apr 28.

Acute Gynaecology, Early Pregnancy and Advanced Endosurgery Unit, Nepean Hospital, Kingswood, Australia; Sydney Medical School Nepean, University of Sydney, Sydney, Australia; OMNI Gynaecological Ultrasound and Care, St. Leonards, Australia.

Objective: It is well-established that there is a strong association between ovarian endometriomas (OE) and deep endometriosis (DE) and rectouterine pouch (RP) obliteration. We aimed to determine the prevalence of DE and RP obliteration in the presence of normal ovaries.

Methods: We conducted a multicentre retrospective cohort study from January 2009 to December 2017 using a prospective multicentre data registry. Read More

Cancer 2020 05;126 Suppl 10:2469-2480

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Background: Greater than 80% of women presenting for breast cancer treatment in Uganda have late-stage disease, which is attributable to a dysfunctional referral system and a lack of recognition of the early signs and symptoms among primary health care providers, and compounded by the poor infrastructure and inadequate human capacity. Improving the breast health care system requires a systemic approach beginning with situational analysis to identify systematic gaps that prevent sustainable improvements in outcome.

Methods: The authors performed a situational analysis of the breast health care system using methods developed by the Breast Health Global Initiative. Read More

Breast Cancer 2020 Jul 30;27(4):785-790. Epub 2020 Jan 30.

Department of Pathology, Saitama Medical University, Iruma-gun, Japan.

Secretory breast carcinoma constitutes the majority of breast cancers in children and young people less than 20 years of age. Noninvasive examination is particularly necessary for the diagnosis of breast carcinoma in children. Herein, we report a case of secretory breast carcinoma in a 6-year-old girl with psychomotor retardation. Read More

Aesthetic Plast Surg 2020 06 17;44(3):993-1005. Epub 2020 Jan 17.

Department of Plastic Surgery, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Xuhui District, Shanghai, 200031, People's Republic of China.

Background: The cutaneous wound healing process mainly comprises re-epithelialization, fibrosis, and neovascularization. Impaired wound healing is common but tricky in plastic surgery. Aldehyde dehydrogenase 2 (ALDH2), the most effective subset of the ALDH enzyme family, is known to exert a major role in detoxification of aldehydes. Read More

Am J Clin Pathol 2019 11;152(6):782-798

Department of Pathology, Duke University Hospital, Durham, NC.

Objectives: Use of fine-needle aspiration/needle core biopsy (FNA/CNB) in evaluating hematolymphoid processes has been debated. We investigate its applicability in various clinicopathologic settings.

Methods: We retrospectively analyzed 152 cases of FNA/CNB. Read More

Eplasty 2018 5;18:e1. Epub 2018 Jan 5.

The Burn Center, Department of Surgery, MedStar Washington Hospital Center, Washington, DC.

Proteins of the matrix metalloproteinases family play a vital role in extracellular matrix maintenance and basic physiological processes in tissue homeostasis. The function and activities of matrix metalloproteinases in response to compression therapies have yet to be defined. Here, a swine model of hypertrophic scar was used to profile the transcription of all known 26 matrix metalloproteinases in scars treated with a precise compression dose. Read More

Wound Repair Regen 2017 11 8;25(6):972-975. Epub 2018 Feb 8.

Department of Plastic Surgery, Wound Repair and Regeneration, Fukuoka University, School of Medicine, Fukuoka, Japan.

NPWT with instillation and dwell time (NPWTi-d), which combines NPWT with wound irrigation, has been clinically applied as a more effective treatment than conventional NPWT. Commercially available recombinant human basic fibroblast growth factor (rh-bFGF) has been demonstrated to be beneficial for use over the wound beds. The objective of this study was to evaluate the effectiveness of combined treatment with NPWTi-d and rh-bFGF. Read More

Clin Nucl Med 2017 Dec;42(12):e498-e503

From the *Regional Center of Nuclear Medicine, Hospital University of Pisa, Pisa; †Department of Nuclear Medicine, Radiology and Clinical Pathology, "S. Maria della Misericordia" Hospital, Rovigo, Italy; ‡Servicio de Medicina Nuclear, Hospital Clínico San Carlos, Madrid, Spain; §Unit of Senology Hospital University of Pisa, Pisa, Italy; ∥Nuclear Medicine and Diagnostic Imaging Section, Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria; and ¶Department of Radiology, University of Southern California, Los Angeles, CA.

Purpose: Regarding radioguided surgery, the concept of "radioguided occult lesion localization" (ROLL) is based on both preoperative interventional imaging and intraoperative radioguided detection of a clinically occult neoplastic lesion.

Methods: This methodology consists in the direct administration into the lesion of Tc-macroaggregated human albumin formed by relatively large particles retained at the injection site, which direct radioguided excisional biopsy.

Results: This modality has expanded from the classic application of ROLL for nonpalpable breast lesions to other tumors, such as solitary pulmonary nodules or recurrences from differentiated thyroid carcinoma. Read More

Cell Mol Life Sci 2018 02 19;75(3):547-561. Epub 2017 Sep 19.

The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, L406A, Tsinghua Campus, The University Town, Shenzhen, 518055, China.

Mesenchymal stem cells (MSCs) are heterogeneous likely consisting of subpopulations with various therapeutic potentials. Here we attempted to acquire a subset of MSCs with enhanced effect in wound healing. We found that human placental MSCs expressing platelet-derived growth factor (PDGF) receptor (PDGFR)-β exhibited greater proliferation rates and generated more colony-forming unit-fibroblast (CFU-F), compared to PDGFR-β MSCs. Read More

Neurosurg Focus 2017 Sep;43(3):E2

Department of Neurosurgery, NYU Langone Medical Center, New York, New York.

Fifty years before a report on the complete bitemporal lobectomy syndrome in primates, known as the Klüver-Bucy syndrome, was published, 2 talented investigators working at the University College in London, England-neurologist Sanger Brown and physiologist Edward Schäfer-also made this discovery. The title of their work was "An investigation into the functions of the occipital and temporal lobes of the monkey's brain," and it involved excisional brain surgery in 12 monkeys. They were particularly interested in the then-disputed primary cortical locations relating to vision and hearing. Read More

Biomed Res Int 2017 1;2017:3105780. Epub 2017 Aug 1.

Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong 510515, China.

Mesenchymal stem cells are an attractive cell type for cytotherapy in wound healing. The authors recently developed a novel, adipose-tissue-derived, injectable extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) for stem cell therapy. This study was designed to assess the therapeutic effects of ECM/SVF-gel on wound healing and potential mechanisms. Read More

Orbit 2017 Dec 19;36(6):433-435. Epub 2017 Jul 19.

a Illinois Eye and Ear Infirmary , Chicago , Illinois , USA.

Hidrocystomas are benign, cystic lesions of eccrine and apocrine sweat glands. The literature on hidrocystomas is sparse, consisting of a handful of case reports and limited retrospective reviews. This is the first known bi-institutional, retrospective, chart review aimed to elucidate the demographics and basic clinical presentation of hidrocystomas. Read More

Q J Nucl Med Mol Imaging 2017 Sep 1;61(3):247-270. Epub 2017 Jun 1.

Section of Nuclear Medicine and Diagnostic Imaging, Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria -

The sentinel lymph node (SLN) biopsy is probably the most well-known radioguided technique in surgical oncology. Today SLN biopsy reduces the morbidity associated with lymphadenectomy and increases the identification rate of occult lymphatic metastases by offering the pathologist the lymph nodes with the highest probability of containing metastatic cells. These advantages may result in a change in clinical management both in melanoma and breast cancer patients. Read More

Dermatol Surg 2017 Sep;43(9):1150-1156

*University of Arizona College of Medicine-Tucson, Tucson, Arizona; †University of Arizona College of Medicine-Phoenix, Phoenix, Arizona.

Background: A realistic model for the instruction of basic dermatologic procedural skills was developed, while simultaneously increasing medical student exposure to the field of dermatology.

Objective: The primary purpose of the authors' study was to evaluate the utilization of a fresh-tissue cadaver model (FTCM) as a method for the instruction of common dermatologic procedures. The authors' secondary aim was to assess students' perceived clinical skills and overall perception of the field of dermatology after the lab. Read More

J Surg Educ 2017 Sep - Oct;74(5):889-897. Epub 2017 Mar 23.

Division of Plastic & Reconstructive Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:

Objective: To describe the development of cognitive task analysis (CTA)-based multimedia educational videos for surgical trainees in plastic surgery.

Design: A needs assessment survey was used to identify 5 plastic surgery skills on which to focus the educational videos. Three plastic surgeons were video-recorded performing each skill while describing the procedure, and were interviewed with probing questions. Read More

J Ethnopharmacol 2017 Feb 11;198:291-301. Epub 2017 Jan 11.

Department of Pharmacology, Shantou University Medical College, Shantou, Guangdong, People's Republic of China. Electronic address:

Ethno-pharmacological Relevance: Hibiscus rosa-sinensis L. (HRS), a folk medicine named Zhujin in China, possess anti-tumor, antioxidant, antibacterial, low density lipoprotein oxidation prevention and macrophage death prevention effects. The leaves and red flowers of HRS have been traditionally used to treat with furuncle and ulceration. Read More

Int J Appl Basic Med Res 2016 Apr-Jun;6(2):143-5

N. K. P. Salve Institute of Medical Sciences and Research Centre, Nagpur, Maharashtra, India.

A 34-year-old female patient presented with a nodular mass near the right lateral canthus since 1 year. The mass was nodular, pigmented with irregular surface and had a very well-defined margins. A wide excisional biopsy was done for the same. Read More

J Dermatol Sci 2015 Sep 10;79(3):241-51. Epub 2015 Jun 10.

State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China; Cell-Based Therapy Center, Daping Hospital, Third Military Medical University, Chongqing 400042, China. Electronic address:

Background: Wound healing is impaired in diabetes mellitus. The underlying mechanism involved in this process is still unknown. The Akt/mTOR signaling pathway plays a crucial role in the pathogenesis of diabetes. Read More

Pathol Int 2015 Jun 20;65(6):293-300. Epub 2015 Mar 20.

Breast Surgery Division, National Cancer Center Hospital, Tokyo, Japan.

Intraductal papillary lesions of the breast constitute a heterogeneous entity, including benign intraductal papilloma (IDP) with or without atypia and malignant papillary carcinoma. Differentiating between these diagnoses can be challenging. We re-evaluated core biopsy specimens that were diagnosed as IDP and the corresponding surgical excision specimens, and assessed the potential risk for the diagnosis to be modified to malignancy based on excision. Read More

Plast Surg (Oakv) 2014 ;22(3):175-8

Department of Oncology/Surgery, University of Calgary, Calgary, Alberta.

Background: Family physicians (FPs) have an opportunity to diagnose pigmented lesions early with a timely biopsy.

Objective: To assess current biopsy practices used by FPs in diagnosing melanoma.

Methods: A computer-generated random sample of 200 practicing FPs from large and small communities in Southwestern Ontario was identified from the College of Physicians and Surgeons of Ontario physician directory. Read More

Cytotherapy 2014 Nov;16(11):1467-1475

Key Laboratory of Wound Repair and Regeneration of Chinese People's Liberation Army (PLA), The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, PR China; Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, PR China. Electronic address:

Background Aims: Mesenchymal stromal cells (MSCs) have been documented to improve delayed wound healing in diabetes, but the underlying mechanism remains obscure. We aimed to investigate whether the therapeutic effects on wounds was associated with metabolic alterations by paracrine action of MSCs.

Methods: MSCs from mice with high-fat diet/streptozotocin-induced diabetes or wild-type C57BL/6 mice were evaluated for their paracrine potential in vitro using enzyme-linked immunosorbent assay and immunohistochemical staining assay. Read More

Wound Repair Regen 2014 Nov-Dec;22(6):720-9. Epub 2015 Jan 8.

Department of Surgery, Davis Heart & Lung Research Institute, Center for Regenerative Medicine and Cell Based Therapies, Comprehensive Wound Center, The Ohio State University Wexner Medical Center, Columbus, Ohio.

We recently performed proteomic characterization of a modified collagen gel (MCG) dressing and reported promising effects of the gel in healing full-thickness excisional wounds. In this work, we test the translational relevance of our aforesaid findings by testing the dressing in a swine model of chronic ischemic wounds recently reported by our laboratory. Full-thickness excisional wounds were established in the center of bipedicle ischemic skin flaps on the backs of animals. Read More