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    63 results match your criteria Basic Excisional Surgery

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    Matrix Metalloproteinases Are Differentially Regulated and Responsive to Compression Therapy in a Red Duroc Model of Hypertrophic Scar.
    Eplasty 2018 5;18:e1. Epub 2018 Jan 5.
    The Burn Center, Department of Surgery, MedStar Washington Hospital Center, Washington, DC.
    Proteins of the matrix metalloproteinases family play a vital role in extracellular matrix maintenance and basic physiological processes in tissue homeostasis. The function and activities of matrix metalloproteinases in response to compression therapies have yet to be defined. Here, a swine model of hypertrophic scar was used to profile the transcription of all known 26 matrix metalloproteinases in scars treated with a precise compression dose. Read More

    Evaluation of the use of recombinant human basic fibroblast growth factor in combination with negative pressure wound therapy with instillation and dwell time in porcine full-thickness wound model.
    Wound Repair Regen 2017 11 8;25(6):972-975. Epub 2018 Feb 8.
    Department of Plastic Surgery, Wound Repair and Regeneration, Fukuoka University, School of Medicine, Fukuoka, Japan.
    NPWT with instillation and dwell time (NPWTi-d), which combines NPWT with wound irrigation, has been clinically applied as a more effective treatment than conventional NPWT. Commercially available recombinant human basic fibroblast growth factor (rh-bFGF) has been demonstrated to be beneficial for use over the wound beds. The objective of this study was to evaluate the effectiveness of combined treatment with NPWTi-d and rh-bFGF. Read More

    Radioguided Occult Lesion Localization: Technical Procedures and Clinical Applications.
    Clin Nucl Med 2017 Dec;42(12):e498-e503
    From the *Regional Center of Nuclear Medicine, Hospital University of Pisa, Pisa; †Department of Nuclear Medicine, Radiology and Clinical Pathology, "S. Maria della Misericordia" Hospital, Rovigo, Italy; ‡Servicio de Medicina Nuclear, Hospital Clínico San Carlos, Madrid, Spain; §Unit of Senology Hospital University of Pisa, Pisa, Italy; ∥Nuclear Medicine and Diagnostic Imaging Section, Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria; and ¶Department of Radiology, University of Southern California, Los Angeles, CA.
    Purpose: Regarding radioguided surgery, the concept of "radioguided occult lesion localization" (ROLL) is based on both preoperative interventional imaging and intraoperative radioguided detection of a clinically occult neoplastic lesion.

    Methods: This methodology consists in the direct administration into the lesion of Tc-macroaggregated human albumin formed by relatively large particles retained at the injection site, which direct radioguided excisional biopsy.

    Results: This modality has expanded from the classic application of ROLL for nonpalpable breast lesions to other tumors, such as solitary pulmonary nodules or recurrences from differentiated thyroid carcinoma. Read More

    Platelet-derived growth factor receptor beta identifies mesenchymal stem cells with enhanced engraftment to tissue injury and pro-angiogenic property.
    Cell Mol Life Sci 2018 Feb 19;75(3):547-561. Epub 2017 Sep 19.
    The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, L406A, Tsinghua Campus, The University Town, Shenzhen, 518055, China.
    Mesenchymal stem cells (MSCs) are heterogeneous likely consisting of subpopulations with various therapeutic potentials. Here we attempted to acquire a subset of MSCs with enhanced effect in wound healing. We found that human placental MSCs expressing platelet-derived growth factor (PDGF) receptor (PDGFR)-β exhibited greater proliferation rates and generated more colony-forming unit-fibroblast (CFU-F), compared to PDGFR-β MSCs. Read More

    Sanger Brown and Edward Schäfer before Heinrich Klüver and Paul Bucy: their observations on bilateral temporal lobe ablations.
    Neurosurg Focus 2017 Sep;43(3):E2
    Department of Neurosurgery, NYU Langone Medical Center, New York, New York.
    Fifty years before a report on the complete bitemporal lobectomy syndrome in primates, known as the Klüver-Bucy syndrome, was published, 2 talented investigators working at the University College in London, England-neurologist Sanger Brown and physiologist Edward Schäfer-also made this discovery. The title of their work was "An investigation into the functions of the occipital and temporal lobes of the monkey's brain," and it involved excisional brain surgery in 12 monkeys. They were particularly interested in the then-disputed primary cortical locations relating to vision and hearing. Read More

    Adipose Extracellular Matrix/Stromal Vascular Fraction Gel Secretes Angiogenic Factors and Enhances Skin Wound Healing in a Murine Model.
    Biomed Res Int 2017 1;2017:3105780. Epub 2017 Aug 1.
    Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong 510515, China.
    Mesenchymal stem cells are an attractive cell type for cytotherapy in wound healing. The authors recently developed a novel, adipose-tissue-derived, injectable extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) for stem cell therapy. This study was designed to assess the therapeutic effects of ECM/SVF-gel on wound healing and potential mechanisms. Read More

    Bi-institutional retrospective study on the demographics and basic clinical presentation of hidrocystomas.
    Orbit 2017 Dec 19;36(6):433-435. Epub 2017 Jul 19.
    a Illinois Eye and Ear Infirmary , Chicago , Illinois , USA.
    Hidrocystomas are benign, cystic lesions of eccrine and apocrine sweat glands. The literature on hidrocystomas is sparse, consisting of a handful of case reports and limited retrospective reviews. This is the first known bi-institutional, retrospective, chart review aimed to elucidate the demographics and basic clinical presentation of hidrocystomas. Read More

    Advances in radioguided surgery in oncology.
    Q J Nucl Med Mol Imaging 2017 Sep 1;61(3):247-270. Epub 2017 Jun 1.
    Section of Nuclear Medicine and Diagnostic Imaging, Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria -
    The sentinel lymph node (SLN) biopsy is probably the most well-known radioguided technique in surgical oncology. Today SLN biopsy reduces the morbidity associated with lymphadenectomy and increases the identification rate of occult lymphatic metastases by offering the pathologist the lymph nodes with the highest probability of containing metastatic cells. These advantages may result in a change in clinical management both in melanoma and breast cancer patients. Read More

    The Use of a Fresh-Tissue Cadaver Model for the Instruction of Dermatological Procedures: A Laboratory Study for Training Medical Students.
    Dermatol Surg 2017 Sep;43(9):1150-1156
    *University of Arizona College of Medicine-Tucson, Tucson, Arizona; †University of Arizona College of Medicine-Phoenix, Phoenix, Arizona.
    Background: A realistic model for the instruction of basic dermatologic procedural skills was developed, while simultaneously increasing medical student exposure to the field of dermatology.

    Objective: The primary purpose of the authors' study was to evaluate the utilization of a fresh-tissue cadaver model (FTCM) as a method for the instruction of common dermatologic procedures. The authors' secondary aim was to assess students' perceived clinical skills and overall perception of the field of dermatology after the lab. Read More

    Developing Cognitive Task Analysis-based Educational Videos for Basic Surgical Skills in Plastic Surgery.
    J Surg Educ 2017 Sep - Oct;74(5):889-897. Epub 2017 Mar 23.
    Division of Plastic & Reconstructive Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:
    Objective: To describe the development of cognitive task analysis (CTA)-based multimedia educational videos for surgical trainees in plastic surgery.

    Design: A needs assessment survey was used to identify 5 plastic surgery skills on which to focus the educational videos. Three plastic surgeons were video-recorded performing each skill while describing the procedure, and were interviewed with probing questions. Read More

    The N-butyl alcohol extract from Hibiscus rosa-sinensis L. flowers enhances healing potential on rat excisional wounds.
    J Ethnopharmacol 2017 Feb 11;198:291-301. Epub 2017 Jan 11.
    Department of Pharmacology, Shantou University Medical College, Shantou, Guangdong, People's Republic of China. Electronic address:
    Ethno-pharmacological Relevance: Hibiscus rosa-sinensis L. (HRS), a folk medicine named Zhujin in China, possess anti-tumor, antioxidant, antibacterial, low density lipoprotein oxidation prevention and macrophage death prevention effects. The leaves and red flowers of HRS have been traditionally used to treat with furuncle and ulceration. Read More

    Periocular basal cell carcinoma in a young school teacher.
    Int J Appl Basic Med Res 2016 Apr-Jun;6(2):143-5
    N. K. P. Salve Institute of Medical Sciences and Research Centre, Nagpur, Maharashtra, India.
    A 34-year-old female patient presented with a nodular mass near the right lateral canthus since 1 year. The mass was nodular, pigmented with irregular surface and had a very well-defined margins. A wide excisional biopsy was done for the same. Read More

    Impaired wound healing results from the dysfunction of the Akt/mTOR pathway in diabetic rats.
    J Dermatol Sci 2015 Sep 10;79(3):241-51. Epub 2015 Jun 10.
    State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China; Cell-Based Therapy Center, Daping Hospital, Third Military Medical University, Chongqing 400042, China. Electronic address:
    Background: Wound healing is impaired in diabetes mellitus. The underlying mechanism involved in this process is still unknown. The Akt/mTOR signaling pathway plays a crucial role in the pathogenesis of diabetes. Read More

    Intraductal papillomas on core biopsy can be upgraded to malignancy on subsequent excisional biopsy regardless of the presence of atypical features.
    Pathol Int 2015 Jun 20;65(6):293-300. Epub 2015 Mar 20.
    Breast Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
    Intraductal papillary lesions of the breast constitute a heterogeneous entity, including benign intraductal papilloma (IDP) with or without atypia and malignant papillary carcinoma. Differentiating between these diagnoses can be challenging. We re-evaluated core biopsy specimens that were diagnosed as IDP and the corresponding surgical excision specimens, and assessed the potential risk for the diagnosis to be modified to malignancy based on excision. Read More

    Current biopsy practices for suspected melanoma: A survey of family physicians in Southwestern Ontario.
    Plast Surg (Oakv) 2014 ;22(3):175-8
    Department of Oncology/Surgery, University of Calgary, Calgary, Alberta.
    Background: Family physicians (FPs) have an opportunity to diagnose pigmented lesions early with a timely biopsy.

    Objective: To assess current biopsy practices used by FPs in diagnosing melanoma.

    Methods: A computer-generated random sample of 200 practicing FPs from large and small communities in Southwestern Ontario was identified from the College of Physicians and Surgeons of Ontario physician directory. Read More

    Mesenchymal stromal cells enhance wound healing by ameliorating impaired metabolism in diabetic mice.
    Cytotherapy 2014 Nov;16(11):1467-1475
    Key Laboratory of Wound Repair and Regeneration of Chinese People's Liberation Army (PLA), The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, PR China; Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, PR China. Electronic address:
    Background Aims: Mesenchymal stromal cells (MSCs) have been documented to improve delayed wound healing in diabetes, but the underlying mechanism remains obscure. We aimed to investigate whether the therapeutic effects on wounds was associated with metabolic alterations by paracrine action of MSCs.

    Methods: MSCs from mice with high-fat diet/streptozotocin-induced diabetes or wild-type C57BL/6 mice were evaluated for their paracrine potential in vitro using enzyme-linked immunosorbent assay and immunohistochemical staining assay. Read More

    A modified collagen gel dressing promotes angiogenesis in a preclinical swine model of chronic ischemic wounds.
    Wound Repair Regen 2014 Nov-Dec;22(6):720-9. Epub 2015 Jan 8.
    Department of Surgery, Davis Heart & Lung Research Institute, Center for Regenerative Medicine and Cell Based Therapies, Comprehensive Wound Center, The Ohio State University Wexner Medical Center, Columbus, Ohio.
    We recently performed proteomic characterization of a modified collagen gel (MCG) dressing and reported promising effects of the gel in healing full-thickness excisional wounds. In this work, we test the translational relevance of our aforesaid findings by testing the dressing in a swine model of chronic ischemic wounds recently reported by our laboratory. Full-thickness excisional wounds were established in the center of bipedicle ischemic skin flaps on the backs of animals. Read More

    Teaching elliptical excision skills to novice medical students: a randomized controlled study comparing low- and high-fidelity bench models.
    Indian J Dermatol 2014 Mar;59(2):169-75
    Department of Surgery, Botucatu Medical School, University of the State of São Paulo, Botucatu, Brazil.
    Background: The search for alternative and effective forms of training simulation is needed due to ethical and medico-legal aspects involved in training surgical skills on living patients, human cadavers and living animals.

    Aims: To evaluate if the bench model fidelity interferes in the acquisition of elliptical excision skills by novice medical students.

    Materials And Methods: Forty novice medical students were randomly assigned to 5 practice conditions with instructor-directed elliptical excision skills' training (n = 8): didactic materials (control); organic bench model (low-fidelity); ethylene-vinyl acetate bench model (low-fidelity); chicken legs' skin bench model (high-fidelity); or pig foot skin bench model (high-fidelity). Read More

    The comparison of two negative-pressure wound therapy systems in a porcine model of wound healing.
    Wound Repair Regen 2013 Sep-Oct;21(5):740-5. Epub 2013 Aug 8.
    Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.
    The purpose of this study was to compare two negative-pressure wound healing systems (NPWT), -75 mmHg with a silicone-coated (SC) dressing and -125 mmHg with polyurethane foam dressing (standard of care). In addition, this study compared the effects of two different dressing interfaces, SC dressing and gauze, with -75 mmHg pressure. For both comparisons, two groups of five pigs were evaluated over a 21-day time course. Read More

    Malignant peripheral nerve sheath tumor arising in a traumatic neuroma: a case report.
    Hum Pathol 2013 Oct 21;44(10):2360-4. Epub 2013 May 21.
    Department of Pathology and Laboratory Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, ON, Canada K1H 8L6.
    A 67-year-old woman with a history of breast cancer presented with a soft tissue mass at the site of a remote, non-neoplastic lumbar surgery. Excisional biopsy revealed a traumatic neuroma. Five years later she re-presented with a rapidly growing, tender nodule at the same site. Read More

    Treating a collagen scaffold with a low concentration of nicotine promoted angiogenesis and wound healing.
    J Surg Res 2013 Jun 30;182(2):353-61. Epub 2012 Oct 30.
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    Background: Nicotine, one of the major pharmacologically active agents of cigarette smoke, has various effects on cell proliferation, and it has recently been reported to have angiogenic effects. In our previous study, we showed that the topical administration of nicotine at a low concentration accelerated wound healing. This study aimed to evaluate the efficacy of nicotine and synergistic effects of combination treatment with nicotine and basic fibroblast growth factor (bFGF) in a murine excisional wound model treated with artificial dermis. Read More

    [Open biopsy of bone and soft tissue tumors : guidelines for precise surgical procedures].
    Oper Orthop Traumatol 2012 Sep;24(4-5):403-15; quiz 416-7
    Orthopädische Klinik König-Ludwig Haus, Julius-Maximilians-Universität Würzburg, Brettreichstr. 11, 97074, Würzburg, Deutschland.
    Objective: The objective of an open biopsy is to obtain a sufficient amount of representative tumor tissue in terms of adequate quality and quantity, without adverse effects on later therapy.

    Indications: Suspected malignancy after non-invasive diagnostic procedures. Histopathologic evaluation of tumor entity and grading. Read More

    Improving Wound Healing with Topical Gene Therapy.
    Adv Wound Care (New Rochelle) 2012 Oct;1(5):218-223
    Institute of Reconstructive Plastic Surgery, New York University Langone Medical Center , New York, New York.
    Background: Impaired wound healing remains a major clinical problem with many etiologies. Altering gene expression to enhance healing is an innovative therapeutic approach. In recent years, we have developed a means to topically silence genes at the post-transcriptional level to locally alter wounds and improve the healing process. Read More

    Development and evaluation of multiple tendon injury models in the mouse.
    J Biomech 2012 May 8;45(8):1550-3. Epub 2012 Mar 8.
    McKay Orthopaedic Research Laboratory, University of Pennsylvania, 36th & Hamilton Walk, 424 Stemmler Hall, Philadelphia, PA 19104-6081, USA.
    The mouse has proven to be an advantageous animal model system in basic science research focused on aiding in development and evaluation of potential treatments; however, the small size of mouse tendons makes consistent and reproducible injury models and subsequent biomechanical evaluation challenging for studying tendon healing. In this study, we investigated the feasibility and reproducibility of multiple mouse tendon injury models. Our hypothesis was that incisional (using a blade) and excisional (using a biopsy punch) injuries would result in consistent differences in tendon material properties. Read More

    Mesenchymal stem cells delivered in a microsphere-based engineered skin contribute to cutaneous wound healing and sweat gland repair.
    J Dermatol Sci 2012 Apr 18;66(1):29-36. Epub 2012 Feb 18.
    Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Sciences, General Hospital of PLA, 51 Fu Cheng Road, Beijing, PR China.
    Background: Bone-marrow-derived mesenchymal stem cells (BM-MSCs) can contribute to wound healing after skin injury. However, the role of BM-MSCs on repairing skin appendages in renewal tissues is incompletely explored. Moreover, most preclinical studies suggest that the therapeutic effects afforded by BM-MSCs transplantation are short-lived and relatively unstable. Read More

    Effective wound closure with a new two-component wound closure device (Prineo™) in excisional body-contouring surgery: experience in over 200 procedures.
    Aesthetic Plast Surg 2012 Apr 1;36(2):382-6. Epub 2011 Oct 1.
    Plastic, Aesthetic & Reconstructive Surgery, General Hospital Linz, Krankenhausstrasse 9, 4020, Linz, Austria.
    Background: In excisional body-contouring surgery the surgeon is often confronted with time-consuming closure of long wounds. Recently, a new combination of a self-adhering mesh together with a liquid 2-octyl cyanoacrylate adhesive (Prineo™; Ethicon, Inc., Somerville, NJ, USA) has been introduced to replace intracutaneous running suture. Read More

    Primary lymphoedema and lymphatic malformation: are they the two sides of the same coin?
    Eur J Vasc Endovasc Surg 2010 May 21;39(5):646-53. Epub 2010 Feb 21.
    Division of Vascular Surgery, Georgetown University School of Medicine, Washington, DC 20007, USA.
    Objectives: To clear the confusion regarding the relationship between the 'primary lymphoedema' and (truncular) lymphatic malformation (LM); the latter is one of congenital vascular malformations.

    Materials & Methods: A literature review was carried out on the primary lymphoedema either existing as an independent LM lesion or as a component of the Klippel-Trenaunay syndrome.

    Results: The review was able to provide a contemporary guide/conclusion on the definition and classification, clinical evaluation and clinical management regarding conservative (physical) therapy, reconstructive surgical therapy and ablative/excisional surgical therapy, for the primary lymphoedema as an LM. Read More

    Biochemical evaluation of the therapeutic effectiveness of honey in oral mucosal ulcers.
    Bosn J Basic Med Sci 2009 Nov;9(4):290-5
    Department of Oral and Maxillofacial Surgery, Dental Faculty, Ondokuz Mayis University, Samsun, Turkey.
    The aim of this study was to describe and quantify the therapeutic value of honey in oral mucosal ulcers healing in comparison with Glyceroloxytriester (TGO). We also aimed to biochemically evaluate the healing effects of honey which had been collected from the Blacksea region flora on mucosal ulcers resulting in material loss.Thirty wistar rats (240+/-30 g) were enrolled in this study. Read More

    Residual and recurrent disease rates following LEEP treatment in high-grade cervical intraepithelial lesions.
    Arch Gynecol Obstet 2010 Jul 26;282(1):69-73. Epub 2009 Nov 26.
    1st Department of Obstetrics and Gynecology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey.
    Introduction: Loop electrosurgical excision procedure (LEEP) is a basic procedure in the conization performed on patients with CIN II/III. After excisional therapy, close follow up is essential for the earlier detection of residual and recurrent disease. The value of PAP-smear and HPV-DNA tests for investigation of residual and recurrent disease in patients diagnosed with high-grade intraepithelial lesion after LEEP treatment was purposed. Read More

    Treatment of axillary hyperhidrosis/bromidrosis using VASER ultrasound.
    Aesthetic Plast Surg 2009 May 3;33(3):312-23. Epub 2009 Jan 3.
    Stanford University School of Medicine, 1515 El Camino Real, Suite C, Palo Alto, CA 94306, USA.
    Background: Current methods of treatment for axillary hyperhidrosis and/or bromidrosis are palliative (use of topical aluminum chloride or injections of botulinum toxin type A) or surgically based for more permanence (excisional surgery, endoscopic transthoracic sympathectomy, liposuction/curettage). The surgical approaches have mixed effectiveness and incur the risk of significant side effects and complications.

    Methods: Thirteen patients (3 males, 10 females) with significant axillary hyperhidrosis and/or bromidrosis were recruited, treated with the VASER ultrasound, and followed for 6 months. Read More

    Supplemental surgical treatment to end stage (stage IV-V) of chronic lymphedema.
    Int Angiol 2008 Oct;27(5):389-95
    Department of Surgery, Georgetown University, Washington DC, USA.
    Aim: When the lymphedema reaches to its end stages, the complex decongestive therapy (CDT) and/or compression therapy become less effective and increased risk of systemic/general sepsis to become potentially life threatening condition.

    Methods: To improve its clinical management, excisional surgery was performed on 22 patients for their 33 limbs in the end stage of lymphedema as a supplemental therapy, and its efficacy was retrospectively analyzed. Diagnosis was made by radionuclide lymphoscintigraphy and basic laboratory studies (e. Read More

    Efficacy and mechanisms of vacuum-assisted closure (VAC) therapy in promoting wound healing: a rodent model.
    J Plast Reconstr Aesthet Surg 2009 Oct 9;62(10):1331-8. Epub 2008 Jul 9.
    Division of Plastic & Reconstructive Surgery, Columbia University College of Physicians & Surgeons, New York, NY, USA.
    Background: The vacuum-assisted closure device (VAC) has revolutionised wound care, although molecular mechanisms are not well understood. We hypothesise that the VAC device induces production of pro-angiogenic factors and promotes formation of granulation tissue and healing.

    Methods: A novel rodent model of VAC wound healing was established. Read More

    2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ.
    J Low Genit Tract Dis 2007 Oct;11(4):223-39
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA.
    Objective: To provide updated consensus guidelines for the management of women with cervical intraepithelial neoplasia (CIN) or adenocarcinoma in situ (AIS).

    Participants: A group of 146 experts including representatives from 29 professional organizations, federal agencies, and national and international health organizations met on September 18-19, 2006, in Bethesda, MD, to develop the guidelines. MAJOR CHANGES IN THE GUIDELINES: The management of women with CIN grade 1 (CIN 1) has been modified significantly. Read More

    2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ.
    Am J Obstet Gynecol 2007 Oct;197(4):340-5
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
    A group of 146 experts representing 29 organizations and professional societies met Sept. 18-19, 2006, in Bethesda, MD, to develop revised evidence-based, consensus guidelines for managing women with abnormal cervical cancer screening tests. The management of low-grade cervical intraepithelial neoplasia (CIN) grade 1 has been modified significantly. Read More

    [Breast cancer in men].
    Presse Med 2007 Dec 19;36(12 Pt 3):1919-24. Epub 2007 Apr 19.
    Service de Chirurgie Générale, EPS Habib Bourguiba, Sfax, Tunisia.
    Breast cancer in men is rare and most often occurs at or after the age of 60 years. Prognosis is poor when it is discovered at a late stage, as it often is in men, although it should be easier to detect because men have so little breast tissue. The causal mechanism appears to depend on hormone metabolism abnormalities related to elevated estrogen or prolactin levels. Read More

    Biologic markers of breast cancer in nipple aspirate fluid and nipple discharge are associated with clinical findings.
    Cancer Detect Prev 2007 20;31(1):50-8. Epub 2007 Feb 20.
    Department of Surgery, Ellis Fischel Cancer Center at the University of Missouri, Columbia, One Hospital Drive, Columbia, MO 65212, United States.
    Background: The aim of this prospective study was to assess predictive markers in nipple aspirate fluid (NAF) and pathologic nipple discharge (PND) collected prior to excisional breast biopsy, as well as clinical factors available prior to biopsy, with histopathologic results in women with a radiographically suspicious and/or palpable breast lesion.

    Methods: 208 NAF samples from 191 women were evaluated for the following candidate predictive proteins and cellular markers: prostate-specific antigen (PSA), human glandular kallikrein 2 (hK2), basic fibroblast growth factor (bFGF), S phase fraction (SPF), DNA index, and cytology. Clinical factors included whether or not the lesion was palpable, menopausal status, history of pregnancy, history of birth control or hormone replacement use, and PND. Read More

    Teaching and evaluation of surgical skills in dermatology: results of a survey.
    Arch Dermatol 2004 Nov;140(11):1365-9
    Division of Dermatology, University of Washington School of Medicine, Seattle 98195, USA.
    Objectives: To assess how the surgical skills of residents are taught and evaluated within dermatology residency programs in the United States; to assess which surgical techniques training directors and residents consider important for residents to perform or at least understand by the end of residency training.

    Methods: A 126-question survey was sent to all 106 of the US dermatology residency programs accredited by the Accreditation Council for Graduate Medical Education. Contact was initially made via e-mail. Read More

    Fusiform excision.
    Am Fam Physician 2003 Apr;67(7):1539-44, 1547-8, 1550
    Saginaw Cooperative Hospital, Saginaw, Michigan, USA.
    The fusiform excision technique is commonly used by physicians for removing skin and subcutaneous lesions. The technique requires basic skills in anesthetic administration, lesion excision, and suture closure. Physicians experienced in skin surgery can often perform the procedure unsupervised after two to five precepted sessions. Read More

    Evidence for fibroblast growth factor receptors in myofibroblasts during palatal mucoperiosteal repair.
    Arch Oral Biol 2003 Mar;48(3):213-21
    Maxillofacial Orthognathics, Department of Maxillofacial Reconstruction and Function, Division of Maxillofacial/Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Japan.
    Fibroblast growth factors (FGFs) regulate cell growth and differentiation and play crucial roles in the process of tissue repair and remodelling. We have previously shown that basic FGF is widely expressed at the injured site. Since the presence of FGF receptors (FGFRs) determines cellular responsiveness, we examined the localisation of FGFR1, FGFR2 and FGFR3 expression by immunohistochemistry throughout the repair of full-thickness excisional wounds up to 28 days after wounding. Read More

    Characterization of incisional wound healing in inducible nitric oxide synthase knockout mice.
    Surgery 2002 Nov;132(5):866-76
    Departments of Surgery, the Johns Hopkins Medical Institutions, and the Sinai Hospital of Baltimore, Baltimore, MD 21215, USA.
    Background: Excisional wound healing in inducible nitric oxide synthase knockout (iNOS-KO) mice has been previously shown to be impaired compared with their background strain controls. Incisional wounds were created in this experiment in both types of animals and paradoxically were found to heal with the same rapidity and breaking strength in both groups.

    Methods: Dorsal 2. Read More

    [Sentinel node biopsy for malignant melanoma. Technical details and clinical results on 390 patients].
    Minerva Chir 2002 Aug;57(4):481-7
    IRCCS, Divisione di Chirurgia Plastica, Istituto Dermopatico dell'Immacolata, Rome, Italy.
    Background: The purpose of this paper is to present personal experience with sentinel node biopsy for the treatment of malignant melanoma. Technical details influencing the efficacy of the procedure are presented and the clinical, therapeutic and prognostic advantages of this technique discussed.

    Methods: A total of 390 consecutive patients with primary skin melanoma (T2-3,N0,M0) underwent sentinel node biopsy between March 1996 and May 2001. Read More

    Bizarre parosteal osteochondromatous proliferation (Nora's lesion) of the foot.
    Pathol Int 2001 Oct;51(10):816-23
    Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Inashiki, Japan.
    A 22-year-old man presented with a growing lump on the fifth metatarsal of the right foot. Radiographically, the lesion was a calcified mass stuck on to the bone. The T2-weighted magnetic resonance images showed heterogeneity in intensity. Read More

    The management of ductal carcinoma in situ of the breast.
    Endocr Relat Cancer 2001 Mar;8(1):33-45
    Keck School of Medicine, University of Southern California, USC/Norris Comprehensive Cancer Center, 1441 Eastlake Avenue MS74, Los Angeles, California 900033, USA.
    Ductal carcinoma in situ (DCIS) of the breast is a heterogeneous group of lesions with diverse malignant potential. It is the most rapidly growing subgroup within the breast cancer family with more than 42 000 new cases diagnosed in the United States during 2000. Most new cases are nonpalpable and are discovered mammographically. Read More

    Basic fibroblast growth factor stimulates repair of wounded hepatocyte monolayer: modulatory role of protein kinase A and extracellular matrix.
    J Lab Clin Med 1999 Oct;134(4):363-71
    Department of Medicine and Surgery, DVA Medical Center, Long Beach, California, USA.
    The two important repair mechanisms after hepatocyte injury are proliferation and migration of the nearby healthy hepatocytes. Although previous studies have shown that basic fibroblast growth factor (bFGF) levels are markedly elevated after liver injury, the role of bFGF in the repair of the wounded hepatocytes is not well understood. The aim of this study was to delineate the role of bFGF in the repair of the wounded hepatocyte monolayers. Read More

    Angiogenesis inhibitor TNP-470 inhibits murine cutaneous wound healing.
    J Surg Res 1999 Apr;82(2):268-74
    Department of Physiology and Biophysics, Division of Pediatric Surgery, Louisville, Kentucky, 40292, USA.
    Background: TNP-470 (AGM-1470) is a potent inhibitor of angiogenesis with potential therapeutic applications in neoplastic and angio-proliferative diseases. This study evaluated its effect on cutaneous wound healing in a murine dorsal excisional wound model.

    Materials And Methods: Full-thickness wounds (1. Read More

    Protocol for the examination of specimens removed from patients with gastric carcinoma: a basis for checklists. Members of the Cancer Committee, College of American Pathologists, and the Task Force for Protocols on the Examination of Specimens From Patients With Gastric Cancer.
    Arch Pathol Lab Med 1998 Jan;122(1):9-14
    Department of Pathology, Massachusetts General Hospital, Boston 02114, USA.
    A protocol for the pathologic examination and reporting of specimens from patients with gastric carcinoma has been developed by the Cancer Committee of the College of American Pathologists and a multidisciplinary task force of specialists dealing with patients with gastric carcinoma. The protocol incorporates all basic pathology data of diagnostic and prognostic significance appropriate for the treatment of patients with gastric carcinoma. The purpose of the protocol is to serve as a basis for the development of checklists, as on outline for full narrative reporting, as a basis for research protocols, or as a guide for other types of synoptic or reporting formats. Read More

    Growth factors in the repair of partial thickness porcine skin wounds.
    Plast Reconstr Surg 1997 Sep;100(3):657-64
    Brigham/Children's/Harvard Division of Plastic Surgery, Brigham and Women's Hospital, Boston, Mass, USA.
    In 28 porcine partial thickness excisional wounds, the presence of several growth factors was first studied by enzyme-linked immunoadsorbent assay on wound fluid collected in sealed wound chambers. Basic fibroblast growth factor (bFGF) peaked on day 1 at 31.4 pg/ml; platelet derived growth factor (PDGF)-AB on day 3 reached 45. Read More

    Protocol for the examination of specimens from patients with carcinoma of the ampulla of Vater: a basis for checklists. Cancer Committee, College of American Pathologists.
    Arch Pathol Lab Med 1997 Jul;121(7):673-7
    Department of Pathology, Massachusetts General Hospital, Boston, USA.
    A protocol for the pathologic examination and reporting of specimens from patients with carcinoma of the ampulla of Vater has been developed by the Cancer Committee of the College of American Pathologists. The protocol incorporates all basic pathology data of diagnostic and prognostic significance appropriate for the treatment of patients with ampullary carcinoma. The purposes of the protocol are to serve as a basis for the development of checklists, as an outline for full narrative reporting, as a basis for research protocols, or as a guide for other types of synoptic or reporting formats. Read More

    Diagnosis of breast tumors after breast reduction.
    Aesthetic Plast Surg 1996 Sep-Oct;20(5):391-7
    We conducted a retrospective study to evaluate the diagnosability of breast tumors after breast reductions as this is a frequent surgical procedure. The data should shed light on the hypothesis that routine screening methods concerning the diagnosis of breast tumors prove more difficult after breast operations. All women who had undergone breast reduction at our department between January 1989 and December 1994 were examined. Read More

    Assessment of differential cytokine effects on angiogenesis using an in vivo model of cutaneous wound repair.
    J Surg Res 1995 May;58(5):449-59
    Department of Plastic Surgery, Vanderbilt University, Nashville, Tennessee, USA.
    Angiogenesis, or new blood vessel formation, has been a subject of intense investigation in recent years. A major obstacle in this research has been the selection of an appropriate in vivo model with which comparisons to humans can be made as well as a reliable quantitative method. Using the porcine excisional wound healing model, we report a new and simple technique for obtaining objective assessments of the microvascular compartment. Read More

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