Clin Nucl Med 2017 Dec;42(12):e498-e503
From the *Regional Center of Nuclear Medicine, Hospital University of Pisa, Pisa; †Department of Nuclear Medicine, Radiology and Clinical Pathology, "S. Maria della Misericordia" Hospital, Rovigo, Italy; ‡Servicio de Medicina Nuclear, Hospital Clínico San Carlos, Madrid, Spain; §Unit of Senology Hospital University of Pisa, Pisa, Italy; ∥Nuclear Medicine and Diagnostic Imaging Section, Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria; and ¶Department of Radiology, University of Southern California, Los Angeles, CA.
Purpose: Regarding radioguided surgery, the concept of "radioguided occult lesion localization" (ROLL) is based on both preoperative interventional imaging and intraoperative radioguided detection of a clinically occult neoplastic lesion.
Methods: This methodology consists in the direct administration into the lesion of Tc-macroaggregated human albumin formed by relatively large particles retained at the injection site, which direct radioguided excisional biopsy.
Results: This modality has expanded from the classic application of ROLL for nonpalpable breast lesions to other tumors, such as solitary pulmonary nodules or recurrences from differentiated thyroid carcinoma. Read More