437,652 results match your criteria Basic & clinical pharmacology & toxicology[Journal]


Individual radiation protection: idea and research needs.

J Radiol Prot 2019 Feb 22. Epub 2019 Feb 22.

Deputy Director General Office, Federal Authority for Nuclear Regulation (FANR), The Landmark Tower Al Markaziyah West - Abu Dhabi Corniche - First Floor Abu Dhabi, United Arab Emirates, Abu Dhabi, Abu Dhabi, 112021, UNITED ARAB EMIRATES.

The current Radiation Protection System is based on the definition and use of the "effective dose", a complex quantity which is not measurable and normally not easily understood by the general public. National radiation protection requirements and regulations stem from a few basic principles, one of which is the respect of individual annual dose limits, specified in terms of the quantities "effective dose" and "equivalent dose". Another guiding principle is the continuous quest for optimization of individual integrated doses, i. Read More

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http://dx.doi.org/10.1088/1361-6498/ab0979DOI Listing
February 2019

Surgical Results of Carotid Endarterectomy for Twisted Carotid Bifurcation.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, Juntendo University Nerima Hospital, Tokyo, Japan.

Background: The internal carotid artery (ICA) is normally positioned posterolateral to the external carotid artery (ECA) at the carotid bifurcation. An anatomical variation with the ICA positioned medial to the ECA, the so-called twisted carotid bifurcation, is sometimes encountered in patients undergoing carotid endarterectomy (CEA). Little is known about the twisted carotid bifurcation or the implications for CEA. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.282DOI Listing
February 2019

An In Vitro elucidation of the antiaggregatory potential of Diosmin over thermally induced unfolding of hen egg white lysozyme; A preventive quest for lysozyme amyloidosis.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

Protein Amyloid Research Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, UP 202002, India. Electronic address:

Protein misfolding diseases are associated with human pathologies. These neurodegenerative diseases remain challenging task for researchers because of their adverse effect on vital organs system. Lysozyme amyloidosis is also associated with multi-organ dysfunction. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.107DOI Listing
February 2019

Propagermanium, a CCR2 inhibitor, attenuates cerebral ischemia/reperfusion injury through inhibiting inflammatory response induced by microglia.

Neurochem Int 2019 Feb 19. Epub 2019 Feb 19.

State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 210009, China. Electronic address:

CCR2 could recruit immune cells migrating into brain after ischemic stroke. It is unclear whether and why Propagermanium (PG, a CCR2 inhibitor) is able to protect against ischemic injury. Middle cerebral artery occlusion (MCAO) and reperfusion injury in C57BL/6 J male mice were performed in vivo to mimic ischemic stroke. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.02.010DOI Listing
February 2019

Triclosan-loaded chitosan as antibacterial agent for adhesive resin.

J Dent 2019 Feb 19. Epub 2019 Feb 19.

Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, 90035-003, Porto Alegre, RS, Brazil. Electronic address:

Objectives: The aim of this study was to formulate and to evaluate the immediate and long-term physical, chemical and antibacterial properties of an experimental adhesive resin with chitosan or triclosan-loaded chitosan.

Materials And Methods: Chitosan, triclosan and triclosan-loaded chitosan were evaluated for scanning electron microscopy (SEM) and micro-Raman spectroscopy. An experimental adhesive resin was formulated with methacrylate monomers and photoinitiators. Read More

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http://dx.doi.org/10.1016/j.jdent.2019.02.002DOI Listing
February 2019

Developmental profiles of SUMOylation pathway proteins in rat cerebrum and cerebellum.

PLoS One 2019 22;14(2):e0212857. Epub 2019 Feb 22.

School of Biochemistry, Medical Sciences Building, University of Bristol, University Walk, Bristol, United Kingdom.

Protein SUMOylation regulates multiple processes involved in the differentiation and maturation of cells and tissues during development. Despite this, relatively little is known about the spatial and temporal regulation of proteins that mediate SUMOylation and deSUMOylation in the CNS. Here we monitor the expression of key SUMO pathway proteins and levels of substrate protein SUMOylation in the forebrain and cerebellum of Wistar rats during development. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212857PLOS
February 2019

ASB20123: A novel C-type natriuretic peptide derivative for treatment of growth failure and dwarfism.

PLoS One 2019 22;14(2):e0212680. Epub 2019 Feb 22.

National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.

C-type natriuretic peptide (CNP) and its receptor natriuretic peptide receptor B (NPR-B) are physiological potent positive regulators of endochondral bone growth; therefore, the CNP/NPR-B signaling pathway is one of the most promising therapeutic targets for treating growth failure and dwarfism. In this article, we summarized the pharmacological properties of a novel CNP analog peptide ASB20123 as a therapeutic agent for short stature. ASB20123, one of the CNP/ghrelin chimeric peptides, is composed of CNP(1-22) and human ghrelin(12-28, E17D). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212680PLOS
February 2019

NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice.

PLoS One 2019 22;14(2):e0212523. Epub 2019 Feb 22.

School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China.

Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD)+ biosynthesis. Through its NAD+-biosynthetic activity, NAMPT influences the activity of NAD+-dependent enzymes, such as sirtuins. NAMPT is able to modulate processes involved in the pathogenesis of non-alcohol induced fatty liver disease (NAFLD), but the roles NAMPT plays in development of alcoholic liver disease (ALD) still remain unknown. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212523PLOS
February 2019

How people living with diabetes in Indonesia learn about their disease: A grounded theory study.

PLoS One 2019 22;14(2):e0212019. Epub 2019 Feb 22.

Nursing, Midwifery and Nutrition, College of Healthcare Sciences, James Cook University, Townsville, Australia.

Background: Diabetes education has been found to impact positively on self-management by people with diabetes although little is known about the process by which they assimilate information. The aim of this study was to generate a theory explaining the process by which people with diabetes learn about their disease in Indonesia.

Methods: This study employed a grounded theory methodology influenced by constructivism and symbolic interactionism. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212019PLOS
February 2019

The effect of stride length on lower extremity joint kinetics at various gait speeds.

PLoS One 2019 22;14(2):e0200862. Epub 2019 Feb 22.

Department of Biomedical Engineering, University of Delaware, Newark, DE 19713, United States of America.

Robot-assisted training is a promising tool under development for improving walking function based on repetitive goal-oriented task practice. The challenges in developing the controllers for gait training devices that promote desired changes in gait is complicated by the limited understanding of the human response to robotic input. A possible method of controller formulation can be based on the principle of bio-inspiration, where a robot is controlled to apply the change in joint moment applied by human subjects when they achieve a gait feature of interest. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200862PLOS
February 2019

Uncovering and resolving challenges of quantitative modeling in a simplified community of interacting cells.

PLoS Biol 2019 Feb 22;17(2):e3000135. Epub 2019 Feb 22.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

Quantitative modeling is useful for predicting behaviors of a system and for rationally constructing or modifying the system. The predictive power of a model relies on accurate quantification of model parameters. Here, we illustrate challenges in parameter quantification and offer means to overcome these challenges, using a case example in which we quantitatively predict the growth rate of a cooperative community. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000135DOI Listing
February 2019

Implications of Classification of Os Trigonum: A Study Based on Computed Tomography Three-Dimensional Imaging.

Med Sci Monit 2019 Feb 22;25:1423-1428. Epub 2019 Feb 22.

Department of Orthopedic, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland).

BACKGROUND The os trigonum is an accessory bone that is not fully fused with the talus during secondary ossification, and is one of the risk factors of posterior malleolus impact syndrome. The purpose of this study was to classify the os trigonum and to guide the diagnosis and treatment of related clinical diseases. MATERIAL AND METHODS Ankle computed tomography (CT) scans of 586 Chinese patients between October 2014 and October 2018 were reviewed. Read More

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http://dx.doi.org/10.12659/MSM.914485DOI Listing
February 2019

Generic Primitive Detection in Point Clouds Using Novel Minimal Quadric Fits.

IEEE Trans Pattern Anal Mach Intell 2019 Feb 19. Epub 2019 Feb 19.

We present a novel and effective method for detecting 3D primitives in cluttered, unorganized point clouds, without axillary segmentation or type specification. We consider the quadric surfaces for encapsulating the basic building blocks of our environments in a unified fashion. We begin by contributing two novel quadric fits targeting 3D point sets that are endowed with tangent space information. Read More

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http://dx.doi.org/10.1109/TPAMI.2019.2900309DOI Listing
February 2019

Enhancement of bone consolidation using high-frequency pulsed electromagnetic fields (HF-PEMFs): An experimental study on rats.

Bosn J Basic Med Sci 2019 Feb 20. Epub 2019 Feb 20.

"Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

In vitro studies showed that high-frequency pulsed electromagnetic fields (HF-PEMFs) increase the activity/expression of early and late osteogenic markers and enhance bone mineralization. The main aim of this study was to investigate the in vivo effects of HF-PEMFs on fracture healing using a rat model. A femur fracture was established by surgery in 20 male Wistar rats. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3854DOI Listing
February 2019

Meeting Yield and Conservation Objectives by Harvesting Both Juveniles and Adults.

Am Nat 2019 Mar 25;193(3):373-390. Epub 2019 Jan 25.

Sustainable yields that are at least 80% of the maximum sustainable yield are sometimes referred to as "pretty good yields" (PGY). The range of PGY harvesting strategies is generally broad and thus leaves room to account for additional objectives besides high yield. Here, we analyze stage-dependent harvesting strategies that realize PGY with conservation as a second objective. Read More

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http://dx.doi.org/10.1086/701631DOI Listing

β-Arrestin-2-ERK1/2 cPLAα axis mediates TLR4 signaling to influence eicosanoid induction in ischemic brain.

FASEB J 2019 Feb 22:fj201802020R. Epub 2019 Feb 22.

Department of Emergency Medicine and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China.

LPS has been shown to elicit neuroinflammation associated with the up-regulation of the eicosanoid pathway in animal models; however, the regulatory mechanisms of TLR4 in brain neuroinflammatory conditions remain elusive. β-Arrestins are key regulators of the GPCR signaling pathway and are involved in the leukotriene B4-induced leukocyte migration to initiate inflammatory response. However, the roles of β-arrestins in eicosanoid regulation and related diseases are not clear. Read More

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http://dx.doi.org/10.1096/fj.201802020RDOI Listing
February 2019

C-reactive protein exacerbates epithelial-mesenchymal transition through Wnt/β-catenin and ERK signaling in streptozocin-induced diabetic nephropathy.

FASEB J 2019 Feb 22:fj201801865RR. Epub 2019 Feb 22.

Ministry of Education (MOE) Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, China.

Previous studies have reported the pathogenic role of C-reactive protein (CRP) during diabetic kidney disease (DKD) in human CRP transgenic and Crp mice. However, because humans and mice have inverse acute phase expression patterns of CRP and serum amyloid P component, this could lead to the inaccurate evaluation of CRP function with the above-mentioned CRP transgenic mouse. But different from mice, rats have the same acute phase protein expression pattern as human, which might avoid this problem and be a better choice for CRP function studies. Read More

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http://dx.doi.org/10.1096/fj.201801865RRDOI Listing
February 2019

Chiral Superbases with Extended Hydrogen Bond Networks.

J Org Chem 2019 Feb 22. Epub 2019 Feb 22.

Extended hydrogen bond networks can substantially increase basicity through stabilization of the resultant conjugate acid. In this study, the chiral superbases (9-11) having anilinyl substituents attached to the prototype superbase 1,8-bis(dimethylamino)naphthalene 1 are examined using DFT methods (PBE1PBE/6-311+G(d,p). While in the gas phase, these are more basic than 1, in THF solution they are slightly weaker bases than 1. Read More

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http://dx.doi.org/10.1021/acs.joc.9b00048DOI Listing
February 2019

Tuning interaction parameters of thermoplastic polyurethanes in a binary solvent to achieve precise control over micro-phase separation.

J Chem Inf Model 2019 Feb 22. Epub 2019 Feb 22.

Thermoplastic polyurethanes (TPUs) are designed using a large variety of basic building blocks but are only synthesized in a limited number of solvent systems. Understanding the behavior of the copolymers in a selected solvent system is of particular interest to tune the intricate balance of micro-phase separation/mixing, which is the key mechanism behind the structure formation in TPUs. Here, we present a computationally efficient approach for selecting TPU building blocks and solvents based on their Flory-Huggins interaction parameters for a precise control over the micro-phase separation/mixing. Read More

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http://dx.doi.org/10.1021/acs.jcim.8b00781DOI Listing
February 2019

Enhanced Dispersion and Polarization Interactions Achieved through Dithiophosphate Group Incorporation Yield a Dramatic Binding Affinity Increase for an RNA Aptamer-Thrombin Complex.

J Am Chem Soc 2019 Feb 22. Epub 2019 Feb 22.

Regiospecific replacement of a single phosphate (PO2) by a dithiophosphate (PS2) group in an RNA can dramatically increase its binding affinity for a target protein. Thus, complexes between anti-thrombin and anti-VEGF RNA aptamers with single dithiophosphate moieties and thrombin and VEGF, respectively, display equilibrium dissociation constants K of ca. 1 pM, 1000-fold tighter than the native RNA complexes (ca. Read More

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http://dx.doi.org/10.1021/jacs.9b00104DOI Listing
February 2019

A course-based undergraduate research experience in biochemistry that is suitable for students with various levels of preparedness.

Authors:
Shameka J Shelby

Biochem Mol Biol Educ 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemistry, Biochemistry, and Physics, Florida Southern College, Lakeland, Florida 33801.

Due to resource limitations at predominantly undergraduate institutions, research opportunities for non-senior students can be limited. To provide opportunities for a variety of students to gain exposure to research, a course-based undergraduate research experience (CURE) was designed and conducted. Coupled inquiry was used to allow underclassmen and upperclassmen to participate. Read More

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http://dx.doi.org/10.1002/bmb.21227DOI Listing
February 2019

Microfabricated liquid junction hybrid capillary electrophoresis-mass spectrometry interface for fully automated operation.

Electrophoresis 2019 Feb 22. Epub 2019 Feb 22.

Institute of Analytical Chemistry of the Czech Academy of Sciences, Brno, Czech Republic.

One of the challenging instrumental aspects in coupling an automated capillary electrophoresis instrument with electrospray ionization (ESI) mass spectrometry (CE-MS) is finding the balance between the stability, reproducibility and sensitivity of the analysis and compatibility with the standard CE instrumentation. Here we present a development of a new liquid junction based electrospray interface for automated CE-MS, with a focus on the technical design followed by computer modeling of transport conditions as well as characterization of basic performance of the interface. This hybrid arrangement designed as a microfabricated unit attachable to the automated CE instrument allows using of a wide range of separation capillaries with respect to their diameter, length or internal coating (e. Read More

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http://dx.doi.org/10.1002/elps.201900049DOI Listing
February 2019

Lung health in older adults.

Age Ageing 2019 Feb 22. Epub 2019 Feb 22.

Department of Complex Needs, Lincoln County Hospital, Greetwell Road, Lincoln, UK.

One in five people in the UK live with lung disease. The National Taskforce for Lung Health, supported by 29 organisations, published its report in December 2018 with 43 recommendations for the UK, most of which are highly relevant to older adults. Prevention is key, especially relating to the introduction of clean air zones and air pollution alerts. Read More

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http://dx.doi.org/10.1093/ageing/afz008DOI Listing
February 2019
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Identification of workers with past asbestos exposure in Tuscany eligible to health surveillance programme.

Med Lav 2019 Feb 22;110(1):46-55. Epub 2019 Feb 22.

Istituto per lo Studio e la Prevenzione Oncologica (ISPO), Firenze.

Background: In 2016 the Administration of the Tuscany Region, Italy, established a health surveillance programme for workers with past asbestos exposure. The programme includes two levels of activities, a local basic health evaluation, and a centralized in-depth evaluation of specific cases.

Objectives: To estimate the number and identify the workers with past exposure to asbestos in Tuscan industrial settings entitled to participate in the health surveillance programme. Read More

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http://dx.doi.org/10.23749/mdl.v110i1.7739DOI Listing
February 2019

QuikLitE, a Framework for Quick Literacy Evaluation in Medicine: Development and Validation.

J Med Internet Res 2019 Feb 22;21(2):e12525. Epub 2019 Feb 22.

Department of Computer Science, University of Massachusetts Lowell, Lowell, MA, United States.

Background: A plethora of health literacy instruments was developed over the decades. They usually start with experts curating passages of text or word lists, followed by psychometric validation and revision based on test results obtained from a sample population. This process is costly and it is difficult to customize for new usage scenarios. Read More

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http://dx.doi.org/10.2196/12525DOI Listing
February 2019

Glycyrrhizic acid renders robust neuroprotection in rodent model of vascular dementia by controlling oxidative stress and curtailing cytochrome-c release.

Nutr Neurosci 2019 Feb 22:1-16. Epub 2019 Feb 22.

a Department of Anatomy, Dr. Arcot Lakshmanaswamy Mudaliar Post Graduate Institute of Basic Medical Sciences , University of Madras , Chennai , India.

Background: Chronic cerebral hypoperfusion (CCH), a concern for neurocognitive health, is linked to various vascular ailments and other comorbidities. This study primarily aims to explain the mitigating effects of glycyrrhizic acid (GA) on cognitive health challenged by chronic cerebral hypoperfusion.

Methods: Adult male Sprague Dawley rats were allocated into four groups: (i) Sham, (ii) Lesion (2VO), (iii) GA treated (20 mg/kg), and (iv) lithium chloride (Li) treated (40 mg/kg). Read More

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http://dx.doi.org/10.1080/1028415X.2019.1580935DOI Listing
February 2019

Reconstruction of three-dimensional vascular models for lymphadenectomy before surgery.

Minim Invasive Ther Allied Technol 2019 Feb 22:1-7. Epub 2019 Feb 22.

c Department of Anatomy, Guangdong Province Key Laboratory of Medical Biomechanics, School of Basic Medicine Science , Southern Medical University , Guangzhou , China.

Introduction: A three-dimensional (3D) model of the pelvic vessels was reconstructed before surgery to aid in the understanding of the individual anatomy and help guide lymphadenectomy performance.

Material And Methods: Thirty patients with early-stage cervical cancer who were scheduled for lymphadenectomy at Nanfang Hospital, Southern Medical University from January 2017 to June 2017 were included. Three-dimensional models of the pelvic vessels were obtained. Read More

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http://dx.doi.org/10.1080/13645706.2019.1569533DOI Listing
February 2019

New human chromosomal sites with 'safe harbor' potential for targeted transgene insertion.

Hum Gene Ther 2019 Feb 22. Epub 2019 Feb 22.

University of Washington, Departments of Pathology & Genome Sciences , Box 357705 , 1959 N.E. Pacific Street Room K072C , Seattle, Washington, United States , 98195-7705 ;

We have identified 35 new sites for targeted transgene insertion that have the potential to serve as new human genomic 'safe harbor' sites. 'Safe harbor' site potential for these 35 sites, located on 16 chromosomes including both arms of the human X chromosome, and for the existing human 'safe harbor' sites AAVS1, hROSA26 and CCR5 was assessed using 8 different desirable, widely accepted criteria for 'safe harbor' sites verifiable with human genomic data. Three representative newly identified sites on human chromosomes 2 and 4 were then experimentally validated by in vitro and in vivo cleavage-sensitivity tests, and analyzed for population-level and cell line-specific sequence variants that might confound site targeting. Read More

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http://dx.doi.org/10.1089/hum.2018.169DOI Listing
February 2019

Single plasmid-based, upgradable and backward compatible adenoviral vector systems.

Hum Gene Ther 2019 Feb 22. Epub 2019 Feb 22.

Chinese Center for Disease Control and Prevention, 12415, National Institute for Viral Disease Control and Prevention, Beijing, China ;

Existing adenoviral vector systems have two drawbacks. It is labor-intensive and time-consuming to load a transgene in these systems, and transgene harboring vectors are dead ends: they cannot be reused to construct a vector carrying another transgene or achieving new characteristics. To conquer these shortcomings, we constructed single plasmid-based adenoviral vector systems where a unique PmeI site was located at the position for insertion of exogenous gene. Read More

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http://dx.doi.org/10.1089/hum.2018.258DOI Listing
February 2019

Quality Control of Therapeutic Peptides by H NMR HiFSA Sequencing.

J Org Chem 2019 Feb 22. Epub 2019 Feb 22.

NMR Solutions Ltd. , 70110 Kuopio , Finland.

Ensuring identity, purity, and reproducibility are equally essential during synthetic chemistry, drug discovery, and for pharmaceutical product safety. Many peptidic APIs are large molecules that require considerable effort for integrity assurance. This study builds on quantum mechanical H iterative Full Spin Analysis (HiFSA) to establish NMR peptide sequencing methodology that overcomes the intrinsic limitations of principal compendial methods in identifying small structural changes or minor impurities that affect effectiveness and safety. Read More

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http://dx.doi.org/10.1021/acs.joc.8b02704DOI Listing
February 2019

Factors influencing changing bowel habits in patients undergoing sphincter-saving surgery for rectal cancer.

Int Wound J 2019 Mar;16 Suppl 1:71-75

Department of Clinical Nursing, University of Ulsan, Seoul, South Korea.

A research survey research was conducted to identify factors affecting changes in bowel habits of rectal cancer patients undergoing sphincter-saving surgery and to provide basic information useful in nursing interventions supporting treatment for rectal cancer patients. The subjects were rectal cancer patients who had undergone sphincter-saving surgery over 2 years ago. The final analysis included 107 patients who had made outpatient visits to the colorectal surgery from 12th to 31st May, 2014. Read More

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http://dx.doi.org/10.1111/iwj.13060DOI Listing

Evaluation of resistive index of the prostate and bladder sonomorphologic parameters as replacements for urodynamics to predict bladder outlet obstruction in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia.

Low Urin Tract Symptoms 2019 Feb 22. Epub 2019 Feb 22.

Department of Radiodiagnosis, King George's Medical University, Lucknow, India.

Objective: This study investigated whether the resistive index (RI) of prostate and bladder sonomorphologic parameters (total prostate volume [TPV], detrusor wall thickness [DWT], intraprostatic protrusion [IPP]) can be used instead of urodynamic studies (UDS) to predict bladder outlet obstruction (BOO) in benign prostatic hyperplasia (BPH) with lower urinary tract symptoms (LUTS).

Methods: Men aged ≥50 years with clinical BPH/LUTS were prospectively enrolled included. Basic evaluations, measurement of sonomorphologic parameters, and UDS were performed in accordance with the International Continence Society's Good Urodynamics Practices protocol. Read More

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http://dx.doi.org/10.1111/luts.12256DOI Listing
February 2019

The Spectrum of Learning and Teaching: The Impact of a Fourth-Year Anatomy Course on Medical Student Knowledge and Confidence.

Anat Sci Educ 2019 Feb 22. Epub 2019 Feb 22.

Department of Physical Therapy, Northeastern University, Boston, Massachusetts.

There is growing demand from accrediting agencies for improved basic science integration into fourth-year medical curricula and inculcation of medical students with teaching skills. The objective of this study was to determine the effectiveness of a fourth-year medical school elective course focused on teaching gross anatomy on anatomical knowledge and teaching confidence. Fourth-year medical student "teacher" participants' gross anatomy knowledge was assessed before and after the course. Read More

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http://dx.doi.org/10.1002/ase.1872DOI Listing
February 2019

Perspectives on Implementation Considerations and Costs of Malaria Case Management Supportive Supervision.

Am J Trop Med Hyg 2019 Feb 19. Epub 2019 Feb 19.

President's Malaria Initiative (PMI) MalariaCare Project, PATH, Washington, District of Columbia.

Between 2012 and 2017, the U.S. President's Malaria Initiative-funded MalariaCare project supported national malaria control programs in sub-Saharan Africa to implement a case management quality assurance (QA) system for malaria and other febrile illnesses. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0362DOI Listing
February 2019

Neuromodulation for the treatment of primary headache syndromes.

Expert Rev Neurother 2019 Feb 22. Epub 2019 Feb 22.

a Department of Systems Neuroscience , University Medical Center Hamburg-Eppendorf , Hamburg , Germany.

Introduction Neuromodulation techniques play an increasing role in the treatment of primary headaches. While initially reserved for refractory cases they are now increasingly taken into consideration in earlier treatment phases and in non-refractory situations. One of the main reasons of this paradigm shift is that most neuromodulation techniques are better tolerated as compared to the majority of pharmacological approaches. Read More

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http://dx.doi.org/10.1080/14737175.2019.1585243DOI Listing
February 2019

Body mass index, body shape, and risk of nasopharyngeal carcinoma: A population-based case-control study in Southern China.

Cancer Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, China.

Whether the association between body size or shape and nasopharyngeal carcinoma (NPC) risk exists or varies by age-specific body size indicators is unclear. In a population-based case-control study conducted in Southern China between 2010 and 2014, self-reported height, weight, and body shape at age 20 and 10 years before interview were collected from 2448 histopathologically confirmed NPC cases and 2534 population-based controls. Body mass index (BMI) was categorized according to the World Health Organization guidelines for Asian populations: underweight (<18. Read More

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http://dx.doi.org/10.1002/cam4.2027DOI Listing
February 2019

β-arrestin 2 negatively regulates NOD2 signalling pathway through association with TRAF6 in microglia after cerebral ischaemia/reperfusion injury.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, P.R. China.

We previously reported that nucleotide-binding oligomerization domain-containing protein (NOD) 2 was involved in the inflammatory responses to cerebral ischaemia/reperfusion (I/R) insult. However, the mechanism by which NOD2 participates in brain ischaemic injury and the regulation of NOD2 in the process are still obscure. Increased β-arrestin 2 (ARRB2) expression was observed in microglia following cerebral I/R in wild-type mice besides the up-regulation of NOD2 and TRAF6. Read More

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http://dx.doi.org/10.1111/jcmm.14223DOI Listing
February 2019

Acid-sensing ion channel 1a is involved in ischaemia/reperfusion induced kidney injury by increasing renal epithelia cell apoptosis.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.

Acidic microenvironment is commonly observed in ischaemic tissue. In the kidney, extracellular pH dropped from 7.4 to 6. Read More

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http://dx.doi.org/10.1111/jcmm.14238DOI Listing
February 2019

Wuzhi capsule regulates chloroacetaldehyde pharmacokinetics behavior and alleviates high-dose cyclophosphamide-induced nephrotoxicity and neurotoxicity in rats.

Basic Clin Pharmacol Toxicol 2019 Feb 21. Epub 2019 Feb 21.

Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, P. R. China.

High-dose cyclophosphamide (HD-CTX) treatment often leads to severe nephrotoxicity and neurotoxicity, which are mainly caused by one of its metabolites, chloroacetaldehyde (CAA). However, there are no effective antidotes to prevent these side effects. The objective of this study was to evaluate the effect of Wuzhi Capsule (WZC) on the pharmacokinetics of CTX and its metabolites in rats, and the attenuation of CAA induced kidney and brain injuries, which was produced at equimolar with 2-dechloroethylcyclophosphamide. Read More

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http://dx.doi.org/10.1111/bcpt.13211DOI Listing
February 2019

Okamoto syndrome has features overlapping with Au-Kline syndrome and is caused by HNRNPK mutation.

Authors:
Nobuhiko Okamoto

Am J Med Genet A 2019 Feb 21. Epub 2019 Feb 21.

Department of Medical Genetics, Osaka Women's and Children's Hospital, Osaka, Japan.

Okamoto syndrome is characterized by severe intellectual disability, generalized hypotonia, stenosis of the ureteropelvic junction with hydronephrosis, cardiac anomalies, and characteristic facial gestalt. Several patients have been reported. The basic mechanism of Okamoto syndrome has not been clarified. Read More

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http://dx.doi.org/10.1002/ajmg.a.61079DOI Listing
February 2019

Safety and efficacy of tirofiban combined with endovascular treatment in acute ischemic stroke.

Eur J Neurol 2019 Feb 21. Epub 2019 Feb 21.

Department of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, China.

Background: Tirofiban is off-label used in clinical practice for acute ischemic stroke (AIS). However, whether tirofiban increases the bleeding risk or improves the outcome of endovascular treatment (EVT) in AIS is unknown. This study evaluated the efficacy and safety of tirofiban in combination with EVT for AIS. Read More

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http://dx.doi.org/10.1111/ene.13946DOI Listing
February 2019

p62 functions as an oncogene in colorectal cancer through inhibiting apoptosis and promoting cell proliferation by interacting with the vitamin D receptor.

Cell Prolif 2019 Feb 22:e12585. Epub 2019 Feb 22.

Department of Digestive Disease and Gastrointestinal Motility Research Room, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Objectives: The role of p62 in cancer is controversial. Evidence has shown that p62 is upregulated in different cancers and promotes tumour growth, such as in liver cancer and lung cancer. However, a recent study showed that the downregulation of p62 in hepatic stellate cells (HSCs) promotes hepatocellular carcinoma (HCC) development. Read More

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http://dx.doi.org/10.1111/cpr.12585DOI Listing
February 2019

Vascular and Non-vascular Contributors to Memory Reduction During Traumatic Brain Injury.

Eur J Neurosci 2019 Feb 21. Epub 2019 Feb 21.

Department of Physiology, University of Louisville, School of Medicine, Louisville, KY, USA.

Traumatic brain injury (TBI) is an increasing health problem. It is a complex, progressive disease that consists of many factors affecting memory. Studies have shown that increased blood-brain barrier (BBB) permeability initiates pathological changes in neuro-vascular network but the role of cerebrovascular dysfunction and its mediated mechanisms associated with memory reduction during TBI are still not well understood. Read More

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http://dx.doi.org/10.1111/ejn.14390DOI Listing
February 2019

Differential roles of epigenetic regulators in the survival and differentiation of oligodendrocyte precursor cells.

Glia 2019 Apr 28;67(4):718-728. Epub 2018 Nov 28.

Neuroprotection Research Laboratory, Department of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.

During development or after brain injury, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes to supplement the number of oligodendrocytes. Although mechanisms of OPC differentiation have been extensively examined, the role of epigenetic regulators, such as histone deacetylases (HDACs) and DNA methyltransferase enzymes (DNMTs), in this process is still mostly unknown. Here, we report the differential roles of epigenetic regulators in OPC differentiation. Read More

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http://dx.doi.org/10.1002/glia.23567DOI Listing

Elaborately Modified BiVO Photoanodes for Solar Water Splitting.

Adv Mater 2019 Feb 21:e1806938. Epub 2019 Feb 21.

Department of Energy Engineering, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.

Photoelectrochemical (PEC) cells for solar-energy conversion have received immense interest as a promising technology for renewable hydrogen production. Their similarity to natural photosynthesis, utilizing sunlight and water, has provoked intense research for over half a century. Among many potential photocatalysts, BiVO , with a bandgap of 2. Read More

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http://dx.doi.org/10.1002/adma.201806938DOI Listing
February 2019

3D Scaffolds to Study Basic Cell Biology.

Adv Mater 2019 Feb 21:e1808110. Epub 2019 Feb 21.

Zoological Institute, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 4, 76131, Karlsruhe, Germany.

Mimicking the properties of the extracellular matrix is crucial for developing in vitro models of the physiological microenvironment of living cells. Among other techniques, 3D direct laser writing (DLW) has emerged as a promising technology for realizing tailored 3D scaffolds for cell biology studies. Here, results based on DLW addressing basic biological issues, e. Read More

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http://dx.doi.org/10.1002/adma.201808110DOI Listing
February 2019

Metformin promotes survivin degradation through AMPK/PKA/GSK-3β-axis in non-small cell lung cancer.

J Cell Biochem 2019 Feb 21. Epub 2019 Feb 21.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China.

Metformin, a first-line antidiabetic drug, has been reported with anticancer activities in many types of cancer. However, its molecular mechanisms remain largely unknown. As a member of inhibitor of apoptosis proteins, survivin plays an important role in the regulation of cell death. Read More

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http://dx.doi.org/10.1002/jcb.28470DOI Listing
February 2019

A novel copper (II) complex activated both extrinsic and intrinsic apoptotic pathways in liver cancerous cells.

J Cell Biochem 2019 Feb 21. Epub 2019 Feb 21.

Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Recent advances have put fundamental focus on the application of copper (II) (Cu [II]) complexes as agents for fighting against cancer. To determine whether [Cu(L)(2imi)] complex as a novel Cu complex can induce apoptosis in HepG2 as cancerous cells and L929 as normal cells via extrinsic or intrinsic apoptotic pathways, both cell lines were treated for 24 and 48 hours at IC concentrations of [Cu(L)(2imi)] complex. Then, the expression of some apoptosis-related genes including p53, caspase-8, bcl-2, and bax were assayed by real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1002/jcb.28491DOI Listing
February 2019

Non-redundant expression of the two katG genes in Vibrio parahaemolyticus V110.

J Basic Microbiol 2019 Feb 21. Epub 2019 Feb 21.

College of Resources and Environment, Huazhong Agricultural University, Wuhan, P.R. China.

Vibrio parahaemolyticus V110 is a marine origin pathogen infecting shrimp. Its resistance to oxidative stress is important for its survival in the complex marine ecosystems. vpa0768 (katG1) and vpa0453 (katG2) were previously found to contribute to the resistance against H O and isopropylbenzene. Read More

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http://dx.doi.org/10.1002/jobm.201800325DOI Listing
February 2019