443,736 results match your criteria Basic & clinical pharmacology & toxicology[Journal]


The Protective Roles of Folic Acid in Preventing Diabetic Retinopathy Are Potentially Associated with Suppressions on Angiogenesis, Inflammation, and Oxidative Stress.

Ophthalmic Res 2019 Apr 24:1-13. Epub 2019 Apr 24.

The First Clinical Medical College of Lanzhou University, Lanzhou, China.

This study aimed to evaluate the therapeutic effect of folic acid (FA) on diabetic retinopathy (DR) in a genetic mouse model of obese type 2 diabetes mellitus (T2D). C57BL/KsJ-db/db (db/db) T2D mice were divided into control, FA, metformin (MET), and FA plus MET groups (n = 10/group). Serum levels of glucose, glycated hemoglobin, and insulin were determined weekly. Read More

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http://dx.doi.org/10.1159/000499020DOI Listing

Glucocorticoids and programming of the microenvironment in heart.

J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

L Zhang, Basic Sciences, Loma Linda University School of Medicine, Loma Linda, United States.

Glucocorticoids are primary stress hormones and can improve neonatal survival when given to pregnant women threatened by preterm birth or to preterm infants. It has become increasingly apparent that glucocorticoids, primarily through interacting with glucocorticoid receptors, play a critical role in late gestational cardiac maturation. Altered glucocorticoid actions contribute to the development and progression of heart disease. Read More

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http://dx.doi.org/10.1530/JOE-18-0672DOI Listing

Distribution of D and D receptor- immunoreactive neurons in the paraventricular nucleus of the hypothalamus in the rat.

J Chem Neuroanat 2019 Apr 21. Epub 2019 Apr 21.

Xinxiang Key Laboratory of Molecular Neurology, Department of Human Anatomy, Xinxiang Medical University, Xinxiang 453003, China; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. Electronic address:

The paraventricular nucleus (PVN) of the hypothalamus is an important center in regulating the functions of internal organs, and it is the key nucleus for coordinating endocrine, behavior and autonomic stress responses. Dopamine receptors are widely expressed in the hypothalamus and participate in the regulation of many vital activities, such as blood pressure and glycolipid metabolism, but the details of the cellular localization of dopamine receptors in the PVN are not clear. The present study investigated the distribution of D and D receptor-immunoreactive (IR) neurons in the subnuclei of the PVN and their co-labeling with vasopressin (VP) and oxytocin (OT) in rats by means of Nissl staining and immunofluorescence. Read More

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http://dx.doi.org/10.1016/j.jchemneu.2019.04.002DOI Listing

Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFRα in Adult Brain.

Cell Rep 2019 Apr;27(4):1073-1089.e5

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan. Electronic address:

Oligodendrocyte progenitor cells (OPCs) are widely distributed cells of ramified morphology in adult brain that express PDGFRα and NG2. They retain mitotic activities in adulthood and contribute to oligodendrogenesis and myelin turnover; however, the regulatory mechanisms of their cell dynamics in adult brain largely remain unknown. Here, we found that global Pdgfra inactivation in adult mice rapidly led to elimination of OPCs due to synchronous maturation toward oligodendrocytes. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.084DOI Listing

Mesenchymal Stem Cell Capping on ECM-Anchored Caspase Inhibitor-Loaded PLGA Microspheres for Intraperitoneal Injection in DSS-Induced Murine Colitis.

Small 2019 Apr 24:e1901269. Epub 2019 Apr 24.

College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea.

Mesenchymal stem cells (MSCs) are considered as a promising alternative for the treatment of various inflammatory disorders. However, poor viability and engraftment of MSCs after transplantation are major hurdles in mesenchymal stem cell therapy. Extracellular matrix (ECM)-coated scaffolds provide better cell attachment and mechanical support for MSCs after transplantation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019012
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http://dx.doi.org/10.1002/smll.201901269DOI Listing
April 2019
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Strongly Coupled Pyridine-V O ·nH O Nanowires with Intercalation Pseudocapacitance and Stabilized Layer for High Energy Sodium Ion Capacitors.

Small 2019 Apr 24:e1900379. Epub 2019 Apr 24.

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering, Wuhan University of Technology, Hubei, Wuhan, 430070, P. R. China.

Developing pseudocapacitive cathodes for sodium ion capacitors (SICs) is very significant for enhancing energy density of SICs. Vanadium oxides cathodes with pseudocapacitive behavior are able to offer high capacity. However, the capacity fading caused by the irreversible collapse of layer structure remains a major issue. Read More

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http://dx.doi.org/10.1002/smll.201900379DOI Listing

CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties.

PLoS Genet 2019 Apr 24;15(4):e1008034. Epub 2019 Apr 24.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

Melanocyte stem cells (McSCs) are the undifferentiated melanocytic cells of the mammalian hair follicle (HF) responsible for recurrent generation of a large number of differentiated melanocytes during each HF cycle. HF McSCs reside in both the CD34+ bulge/lower permanent portion (LPP) and the CD34- secondary hair germ (SHG) regions of the HF during telogen. Using Dct-H2BGFP mice, we separate bulge/LPP and SHG McSCs using FACS with GFP and anti-CD34 to show that these two subsets of McSCs are functionally distinct. Read More

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http://dx.plos.org/10.1371/journal.pgen.1008034
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http://dx.doi.org/10.1371/journal.pgen.1008034DOI Listing
April 2019
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Methanol stem bark extract of Adansonia digitata ameliorates chronic unpredictable mild stress-induced depression-like behavior: Involvement of the HPA axis, BDNF, and stress biomarkers pathways.

J Basic Clin Physiol Pharmacol 2019 Apr 24. Epub 2019 Apr 24.

Department of Pharmacognosy and Drug Development, Ahmadu Bello University, Zaria, Nigeria.

Background Adansonia digitata L. (Malvaceae) is used locally in the management of depressive illnesses, and its antidepressant-like effect has been previously reported. The present study was aimed at determining the effect of the methanol extract of the stem bark of A. Read More

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http://dx.doi.org/10.1515/jbcpp-2018-0153DOI Listing

The effect of silymarin supplementation on cognitive impairment induced by diabetes in rats.

J Basic Clin Physiol Pharmacol 2019 Apr 24. Epub 2019 Apr 24.

Department of Physiology, School of Medicine, Selçuk University, Konya, Turkey.

Background The objective of this investigation was to examine the impact of silymarin supplementation on locomotion, anxiety-related behavior, learning, and memory via several behavioral tests, such as open field, elevated plus maze, and Morris water maze tests in streptozotocin-induced diabetic rats. Methods The rats were divided into the control, diabetes, silymarin, and diabetes plus silymarin groups. On the 30th-35th days of the study, several behavioral tests were performed and blood and brain tissue samples were taken and brain-derived neurotrophic factor (BDNF) and histone deacetylase 3 (HDAC3) levels were analyzed. Read More

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http://dx.doi.org/10.1515/jbcpp-2018-0109DOI Listing

Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model.

FASEB J 2019 Apr 24:fj201802711R. Epub 2019 Apr 24.

Department of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Osteoporosis is a major health problem, making bones fragile and susceptible to fracture. Previous works showed that mechanical loading stimulated bone formation and accelerated fracture healing. Focusing on the role of Wnt3a (wingless/integrated 3a), this study was aimed to assess effects of mechanical loading to the spine, using ovariectomized (OVX) mice as a model of osteoporosis. Read More

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http://dx.doi.org/10.1096/fj.201802711RDOI Listing

Lactate dehydrogenase and baseline markers associated with clinical outcomes of advanced esophageal squamous cell carcinoma patients treated with camrelizumab (SHR-1210), a novel anti-PD-1 antibody.

Thorac Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: A small proportion of patients with advanced esophageal squamous cell carcinoma (ESCC) could benefit from immune checkpoint inhibitors; however, reliable peripheral blood biomarkers for outcomes of anti-PD-1 immunotherapy in ESCC have not been identified.

Methods: The data of 43 patients in the ESCC cohort of a phase I trial at our center were retrospectively reviewed. All patients were administered intravenous camrelizumab (SHR-1210), a novel anti-PD-1 antibody, at doses of 60 mg, 200 mg, or 400 mg (4-week interval after first dose followed by a 2-week schedule) until disease progression or intolerable toxicity. Read More

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http://dx.doi.org/10.1111/1759-7714.13083DOI Listing

Genome-wide association study identified genes in the response to Salmonella pullorum infection in chickens.

Anim Genet 2019 Apr 24. Epub 2019 Apr 24.

Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, 200240, Shanghai, China.

Pullorum is a bacterial disease that threatens the modern poultry industry. Over the years, research on this topic has focused mainly on its epidemiology, whereas the hosts' genetic basis of infection is still vague. In order to identify chickens' genes associated with pullorum, we sequenced 300 New Pudong chicken by double digest genotyping-by-sequencing. Read More

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http://dx.doi.org/10.1111/age.12787DOI Listing

Amphipol-assisted purification method for the highly active and stable photosystem II supercomplex of Chlamydomonas reinhardtii.

FEBS Lett 2019 Apr 24. Epub 2019 Apr 24.

Division of Environmental Photobiology, National Institute for Basic Biology, Nishigo-naka 38, Myodaiji, Okazaki, 444-8585, Japan.

Photosystem II (PSII) splits water and drives electron transfer to plastoquinone via photochemical reactions using light energy. It is surrounded by light-harvesting complex II (LHCII) to form the PSII-LHCII supercomplex. Complete characterization of its structure and function has, however, been hampered due to instability of the complex in the presence of detergent. Read More

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http://dx.doi.org/10.1002/1873-3468.13394DOI Listing

Non-specialist palliative care: A principle-based concept analysis.

Palliat Med 2019 Apr 24:269216319840963. Epub 2019 Apr 24.

School of Nursing and Midwifery, Trinity College Dublin, The University of Dublin, Ireland.

Background: Building palliative care capacity among all healthcare practitioners caring for patients with chronic illnesses, who do not work in specialist palliative care services (non-specialist palliative care), is fundamental in providing more responsive and sustainable palliative care. Varying terminology such as 'generalist', 'basic' and 'a palliative approach' are used to describe this care but do not necessarily mean the same thing. Internationally, there are also variations between levels of palliative care which means that non-specialist palliative care may be applied inconsistently in practice because of this. Read More

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http://dx.doi.org/10.1177/0269216319840963DOI Listing

Basic Structure of Melanoidins Formed in the Maillard Reaction of 3-Deoxyglucosone and γ-Aminobutyric Acid.

J Agric Food Chem 2019 Apr 24. Epub 2019 Apr 24.

Institut für Lebensmitteltechnologie und Lebensmittelchemie, Fachgebiet Lebensmittelchemie und Analytik , Technische Universität Berlin , Gustav-Meyer-Allee 25 , 13355 Berlin , Germany.

Melanoidins are formed in foods during processing through the Maillard reaction between carbohydrates and amino compounds. The aim of this study was to draw conclusions about the formation mechanism and the structure of melanoidins formed at low water contents and low temperatures. In the Maillard reaction of d-glucose and γ-aminobutyric acid at low water contents 3-deoxyglucosone is the most important intermediate. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b00202DOI Listing

A "Superaerophobic" Nickel Phosphide Nanoarray Catalyst for Efficient Hydrogen Evolution at Ultra-High Current Densities.

J Am Chem Soc 2019 Apr 22. Epub 2019 Apr 22.

The design of highly efficient non-noble metal electrocatalysts for large-scale hydrogen production remains an ongoing challenge. We report here a Ni2P nanoarray catalyst grown on a commercial Ni foam substrate, which demonstrates an outstanding electrocatalytic activity and stability in basic electrolyte. The high catalytic activity can be attributed to the favorable electron transfer, superior intrinsic activity and the intimate connection between the nanoarrays and their substrate. Read More

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http://dx.doi.org/10.1021/jacs.9b02527DOI Listing

Porous Crystalline Olefin-Linked Covalent Organic Frameworks.

J Am Chem Soc 2019 Apr 23. Epub 2019 Apr 23.

Department of Chemistry , University of California-Berkeley ; Materials Sciences Division, Lawrence Berkeley National Laboratory; and Kavli Energy NanoSciences Institute, Berkeley , California 94720 , United States.

The first unsubstituted olefin-linked covalent organic framework, termed COF-701, was made by linking 2,4,6-trimethyl-1,3,5-triazine (TMT) and 4,4'-biphenyldicarbaldehyde (BPDA) through Aldol condensation. Formation of the unsubstituted olefin (-CH═CH-) linkage upon reticulation is confirmed by Fourier transform infrared (FT-IR) spectroscopy and solid-state C cross-polarization magic angle spinning (CP-MAS) NMR spectroscopy of the framework and of its C-isotope-labeled analogue. COF-701 is found to be porous (1715 m g) and to retain its composition and crystallinity under both strongly acidic and basic conditions. Read More

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http://dx.doi.org/10.1021/jacs.9b02848DOI Listing

Evaluation of Urinary Proteome Library Generation Methods on Data-Independent Acquisition MS Analysis and its Application in Normal Urinary Proteome Analysis.

Proteomics Clin Appl 2019 Apr 24:e1800152. Epub 2019 Apr 24.

X. Liu, H. Sun, Z. Guo, X. Liu, W. Sun, Core Facility of Instrument, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.

Purpose: As an important part of the data-independent acquisition-mass spectrometry (DIA-MS) analysis approach, spectral library generation is closely related to the final protein identification and quantitation.

Experimental Design: In this study, we tried to evaluate the influence of different sample separation methods (reversed-phase liquid chromatography (RPLC) linear gradient elution and spin column step gradient fractionation) and data acquisition modes (data-dependent acquisition ((DDA) and DIA) on library generation of the human urine proteome.

Results: The RPLC separation method provided more proteins for generating the library than the spin column; however, the spin column library led to identification of more proteins when used for the urine proteome analysis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/prca.2018001
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http://dx.doi.org/10.1002/prca.201800152DOI Listing
April 2019
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Non-inferiority of microencapsulated mesenchymal stem cells to free cells in cardiac repair after myocardial infarction: A rationale for using paracrine factor(s) instead of cells.

Int J Exp Pathol 2019 Apr 24. Epub 2019 Apr 24.

ITMO University, St. Petersburg, Russia.

A major translational barrier to the use of stem cell (SC)-based therapy in patients with myocardial infarction (MI) is the lack of a clear understanding of the mechanism(s) underlying the cardioprotective effect of SCs. Numerous paracrine factors from SCs may account for reduction in infarct size, but myocardial salvage associated with transdifferentiation of SCs into vascular cells as well as cardiomyocyte-like cells may be involved too. In this study, bone marrow-derived rat mesenchymal SC (MSCs) were microencapsulated in alginate preventing viable cell release while supporting their secretory phenotype. Read More

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http://dx.doi.org/10.1111/iep.12312DOI Listing

Detection of N6‑methyladenosine modification residues (Review).

Int J Mol Med 2019 Jun 18;43(6):2267-2278. Epub 2019 Apr 18.

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China.

Among a number of mRNA modifications, N6‑methyladenosine (m6A) modification is the most common type in eukaryotes and nuclear‑replicating viruses. m6A has a significant role in numerous cancer types, including leukemia, brain tumors, liver cancer, breast cancer and lung cancer. Although m6A methyltransferases are essential during RNA modifications, the biological functions of m6A and the underlying mechanisms remain to be fully elucidated, predominantly due to the limited detection methods for m6A. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4169DOI Listing

Construction and validation of an instrument for nursing consultation in outpatient chemotherapy.

Rev Bras Enferm 2019 Mar-Apr;72(2):391-399. Epub 2019 Apr 18.

Universidade Federal de São Paulo, Escola Paulista de Enfermagem. São Paulo-SP, Brasil.

Objective: Construct and validate instrument content for nursing consultation in an adult chemotherapy outpatient clinic.

Method: Methodological study composed of two stages: elaboration of the instrument and validation of content. A literary review of the dimensions of customer care was carried out in the light of Theory of Basic Human Needs Theory, culminating in two instruments: one for admission consultation and other for follow-up. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0031DOI Listing

Teaching-service integration: building the educational workshop in healthcare.

Rev Bras Enferm 2019 Mar-Apr;72(2):375-382. Epub 2019 Apr 18.

Universidade Federal de Santa Catarina. Florianópolis-SC, Brasil.

Objective: To identify the pedagogical strategies and the elements that determine the construction of the educational workshop in healthcare at the teaching-service integration process.

Method: Collective case study with qualitative approach. The cases consisted of two undergraduate courses in nursing. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0008DOI Listing

Evaluation of quality of the family health strategy in the Federal District.

Rev Bras Enferm 2019 Mar-Apr;72(2):367-374. Epub 2019 Apr 18.

Hospital Israelita Albert Einstein.

Aim: To evaluate quality of the Family Health Strategy (FHS) in the National Program for Improving Access and Quality of Primary Care in the Federal District (FD) from the perspective of users.

Methods: Evaluative research carried out in 25 basic health units of the Federal District through a validated questionnaire assessing the following dimensions: access, gateway, bond, service range, coordination, family focus, community orientation, and health professionals.

Results: Service provision, qualification of professionals, quality of professional-user relationship, and continuity of care were the best evaluated dimensions, while family approach, community approach, and access were the worst. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0130DOI Listing

Surface-diffusion-limited growth of atomically thin WS crystals from core-shell nuclei.

Nanoscale 2019 Apr 24. Epub 2019 Apr 24.

Department of Emerging Materials Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, South Korea.

Atomically thin transition metal dichalcogenides (TMDs) have recently attracted great attention since the unique and fascinating physical properties have been found in various TMDs, implying potential applications in next-generation devices. The progress towards developing new functional and high-performance devices based on TMDs, however, is limited by the difficulty in producing large-area monolayer TMDs due to a lack of knowledge of the growth processes of monolayer TMDs. In this work, we have investigated the growth processes of monolayer WS2 crystals using a thermal chemical vapor deposition method, in which the growth conditions were adjusted in a systematic manner. Read More

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http://dx.doi.org/10.1039/c9nr01594aDOI Listing

Improving healthcare through process standardization: a general hospital case study.

Int J Health Care Qual Assur 2019 Mar;32(2):459-469

Tangram TQC, Medvode, Slovenia.

Purpose: The purpose of this paper is to analyze two process standardization theoretical conceptual constructs: process variants unification; and distinction between standard, routine and non-routine processes.

Design/methodology/approach: The authors analyze two conceptual constructs based on a single case study representing a general hospital's (GH) process standardization, approach and results. The authors research whether process standardization implemented in a GH conforms to the process variants unification concept approach and its assumed benefits and whether implemented process standardization enables process management improvement based on distinguishing standard, routine and non-routine processes. Read More

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http://dx.doi.org/10.1108/IJHCQA-06-2018-0142DOI Listing

Safe and sustained expression of human iduronidase after adeno-associated virus 9 intrathecal administration in infant rhesus monkeys.

Hum Gene Ther 2019 Apr 24. Epub 2019 Apr 24.

University of Pennsylvania, Gene Therapy Program , Suite 2000 TRL , 125 S. 31st Street , Philadelphia, Pennsylvania, United States , 19104.

Many neuropathic diseases cause early, irreversible neurologic deterioration, which warrants therapeutic intervention during the first months of life. In the case of mucopolysaccharidosis type I (MPS I), a recessive lysosomal storage disorder that results from a deficiency of the lysosomal enzyme, α-l-iduronidase (IDUA), one of the most promising treatment approaches is to restore enzyme expression through gene therapy. Specifically, administering neurotropic adeno-associated virus (AAV) encoding IDUA into the cerebrospinal fluid (CSF) via suboccipital administration has demonstrated remarkable efficacy in large animals. Read More

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http://dx.doi.org/10.1089/hum.2019.012DOI Listing

Inclusion of Ln(III) in the Complexes of Co(II) with a Mannich Base Ligand: Development of Atmospheric CO Fixation and Enhancement of Catalytic Oxidase Activities.

Inorg Chem 2019 Apr 24. Epub 2019 Apr 24.

Department of Chemistry, University College of Science , University of Calcutta , 92, A. P. C. Road , Kolkata 700009 , West Bengal , India.

The reaction of the Mannich base ligand (HL = N, N'-dimethyl- N, N'-bis(2-hydroxy-3-methoxy-5-methylbenzyl)ethylenediamine) with Co(OAc)·4HO and Ln(III) nitrate salts (Ln = Gd, Tb, and Dy) under basic conditions afforded three carbonato-bridged isostructural tetranuclear heterometallic Co(II)-Ln(III) complexes (CoGdL(μ-CO)(NO)] (1), [CoTbL(μ-CO)(NO)] (2), and [CoDyL(μ-CO)(NO)] (3)) by atmospheric CO fixation. In all structures, two dinuclear [(CoL)Ln(NO)] units are linked via two μ-carbonato groups to form the tetranuclear CoLn core. The geometry around two penta-coordinated Co(II) ions is distorted square pyramid, and that around two nona-coordinated Ln(III) ions is intermediate between "spherical tricapped trigonal prism" and "spherical capped square antiprism" in all complexes. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00121DOI Listing

[Advances in etiology, epidemiology and genetic diversity of ].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Mar;31(1):86-93

Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052, China.

and are three causative agents of human thelaziasis. Most of the reported cases were caused by , occurring in the old world, particularly in Asian and European countries. and have rarely been reported infecting humans in North America. Read More

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http://www.cnki.net/kcms/doi/10.16250/j.32.1374.2018300.html
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http://dx.doi.org/10.16250/j.32.1374.2018300DOI Listing
March 2019
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[Prevalence and fundamental researches of prevention and treatment of toxoplasmosis in China: an overview].

Authors:
Shen Ji-Long Yu Li

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Apr;31(1):71-76

Department of Parasitology and Microbiology, School of Basic Medicine, Anhui Medical University; Anhui Provincial Laboratories of Pathogen Biology and Zoonoses, Anhui Medical University, Hefei 230032, China.

is an important zoonotic pathogen and its infection has a significant impact on human health and animal husbandry. This review presents the research progresses in the epidemic, genotype, pathogenicity, diagnosis, treatment and vaccine development of and toxoplasmosis in China, so as to provide the reference for the study of the pathogen and the disease in the country. Read More

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http://www.cnki.net/kcms/doi/10.16250/j.32.1374.2019012.html
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http://dx.doi.org/10.16250/j.32.1374.2019012DOI Listing
April 2019
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[Epidemic status and control of tick-borne parasitic diseases in China].

Authors:
Li Lan-Hua Zhang Yi

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Mar;31(1):58-62

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Key Laboratory of Parasite and Vector Biology of National Health Commission, China.

Recently, both of the species of tick-borne parasites and cases of tick-borne parasitic diseases in human beings are increasing in China. Tick-borne diseases are considered to be an important public health problem affecting the health of Chinese. In this paper, we summarize the epidemic status and control measures of tick-borne parasitic diseases in China, and put forward that the epidemic status of tick-borne parasitic diseases may be greatly underestimated in China, and the systematic surveillance of tick-borne parasitic diseases on population, vectors and animal hosts is urgently needed. Read More

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http://dx.doi.org/10.16250/j.32.1374.2018310DOI Listing
March 2019
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Two novel ANK1 loss-of-function mutations in Chinese families with hereditary spherocytosis.

J Cell Mol Med 2019 Apr 23. Epub 2019 Apr 23.

Pediatrics Research Institute, Children's Hospital of Fudan University, Shanghai, China.

Hereditary spherocytosis (HS) is the most common inherited haemolytic anaemia disorder. ANK1 mutations account for most HS cases, but pathogenicity analysis and functional research have not been widely performed for these mutations. In this study, in order to confirm diagnosis, gene mutation was screened in two unrelated Chinese families with HS by a next-generation sequencing (NGS) panel and then confirmed by Sanger sequencing. Read More

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http://dx.doi.org/10.1111/jcmm.14343DOI Listing

Exploiting Unique Biological Features of Leukemia Stem Cells for Therapeutic Benefit.

Stem Cells Transl Med 2019 Apr 23. Epub 2019 Apr 23.

Division of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Cancer stem cells play a critical role in disease initiation and insensitivity to chemotherapy in numerous hematologic malignancies and some solid tumors, and these stem cells need to be eradicated to achieve a cure. Key to successful targeting of cancer stem cells is to identify and functionally test critical target genes and to fully understand their associated molecular network in these stem cells. Human chronic myeloid leukemia (CML) is well accepted as one of the typical types of hematopoietic malignancies that are derived from leukemia stem cells (LSCs), serving as an excellent model disease for understanding the biology of LSCs and developing effective, selective, and curative strategies through targeting LSCs. Read More

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http://dx.doi.org/10.1002/sctm.18-0247DOI Listing

Polyglycolic acid-collagen tube combined with collagen-binding basic fibroblast growth factor accelerates gait recovery in a rat sciatic nerve critical-size defect model.

J Biomed Mater Res B Appl Biomater 2019 Apr 23. Epub 2019 Apr 23.

Department of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

Several nerve conduits have been investigated for their potential as alternative sources of autografts for bridging neural gaps. However, autologous nerve transplants remain the most effective for nerve repair. We examined clinically approved nerve conduits containing collagen and polyglycolic acid (PGA-c) combined with collagen-binding basic fibroblast growth factor (bFGF) containing a polycystic kidney disease (PKD) domain and collagen binding domain (CBD) (bFGF-PKD-CBD) in a rat 15-mm sciatic nerve critical-size defect model. Read More

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http://dx.doi.org/10.1002/jbm.b.34391DOI Listing

Eriodictyol alleviates lipopolysaccharide-triggered oxidative stress and synaptic dysfunctions in BV-2 microglial cells and mouse brain.

J Cell Biochem 2019 Apr 23. Epub 2019 Apr 23.

Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi province, PR China.

Oxidative stress takes part in the development of the neurodegenerative disease. Eriodictyol, a flavonoid, commonly presents in citrus fruits, which was well-known for its various bioactivities. The purpose of this study was to investigate the neuroprotective effects of eriodictyol on lipopolysaccharide (LPS)-induced neuroinflammation, oxidative stress, synaptic dysfunctions, and the potential mechanisms involved. Read More

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http://dx.doi.org/10.1002/jcb.28736DOI Listing

Significant changes in hepatic transcriptome and circulating miRNAs are associated with diet-induced metabolic syndrome in apoE3L.CETP mice.

J Cell Physiol 2019 Apr 23. Epub 2019 Apr 23.

Laboratory of Biochemistry, Division of Basic Sciences, University of Crete Medical School, Heraklion, Greece.

Long-term exposure to excess dietary fat leads to obesity and the metabolic syndrome (MetS). The purpose of the present study was to identify global changes in liver gene expression and circulating miRNAs in a humanized mouse model of diet-induced MetS. Male apoE3L. Read More

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http://dx.doi.org/10.1002/jcp.28649DOI Listing

MicroRNA-203 reinforces stemness properties in melanoma and augments tumorigenesis in vivo.

J Cell Physiol 2019 Apr 23. Epub 2019 Apr 23.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

One of the challenges encountered in microRNA (miRNA) studies is to observe their dual role in different conditions and cells. This leads to a tougher prediction of their behavior as gene expression regulators. miR-203 has been identified to play a negative role in the progression of malignant melanoma; however, it has been reported, with dual effect, as both an oncomiR and tumor suppressor miRNA in some malignancies, such as breast cancer, meanwhile, the role of miR-203 in melanoma stem cells or even metastatic cells is unclear. Read More

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http://dx.doi.org/10.1002/jcp.28619DOI Listing
April 2019
2 Reads

Common Bile Duct Ligation as Model for Secondary Biliary Cirrhosis.

Methods Mol Biol 2019 ;1981:237-247

Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.

Cholestatic liver disease covers a range of biliary disorders marked by an impaired bile duct flow. Various conditions can result in bile obstruction including choledocholithiasis, surgical trauma, and autoimmune disorders. Cholestatic liver disease can be mild but generally progresses to more severe conditions with increased hepatobiliary injury, cholangitis, and ultimately liver fibrosis and cirrhosis. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_15DOI Listing
January 2019

Atypical and Typical Bacteria in Children with Community Acquired Pneumonia.

Adv Exp Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Department of Basic Sciences, Wroclaw Medical University, Wroclaw, Poland.

This seeks to determine the pathogens in respiratory specimens and blood serum obtained from children who present with community acquired pneumonia (CAP) diagnosed on the basis of clinical and radiological evidence. The study group consisted of 46 hospitalized children aged 1-11 years. The material for research consisted of pharyngeal swabs and samples of blood serum. Read More

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http://link.springer.com/10.1007/5584_2019_377
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http://dx.doi.org/10.1007/5584_2019_377DOI Listing
April 2019
4 Reads

The Heterogeneity of Renal Stem Cells and Their Interaction with Bio- and Nano-materials.

Adv Exp Med Biol 2019 ;1123:195-216

Dipartimento di Fisica 'E. Fermi', University of Pisa, Pisa, Italy.

For a long time, the kidney has been considered incapable of regeneration. Instead, in recent years, studies have supported the existence of heterogeneity of renal stem/progenitor cells with the ability to regenerate both glomerular and tubular epithelial cells. Indeed, several studies evidence that renal progenitor cells, releasing chemokines, growth factors, microvesicles, and transcription factors through paracrine mechanisms, can induce tissue regeneration and block pathological processes of the kidney. Read More

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http://link.springer.com/10.1007/978-3-030-11096-3_12
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http://dx.doi.org/10.1007/978-3-030-11096-3_12DOI Listing
January 2019
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Characterization and engineering of the Lrp/AsnC family regulator SACE_5717 for erythromycin overproduction in Saccharopolyspora erythraea.

J Ind Microbiol Biotechnol 2019 Apr 23. Epub 2019 Apr 23.

Institute of Physical Science and Information Technology, School of Life Sciences, Anhui University, Hefei, 230601, China.

In this work, we found that the Lrp/AsnC family protein SACE_5717 negatively regulated erythromycin biosynthesis in S. erythraea. Disruption of SACE_5717 led to a 27% improvement in the yield of erythromycin in S. Read More

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http://dx.doi.org/10.1007/s10295-019-02178-2DOI Listing

Identification of microRNA transcriptome reveals that miR-100 is involved in the renewal of porcine intestinal epithelial cells.

Sci China Life Sci 2019 Apr 23. Epub 2019 Apr 23.

Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, School of Life Sciences, Hunan Normal University, Changsha, 410081, China.

MicroRNAs play important roles in various cellular processes, including differentiation, proliferation and survival. Using a pig model, this study sought to identify the miRNAs responsible for crypt-villus axis renewal of the small intestinal epithelium. Compared to the villus upper cells, there were 15 up-regulated and 41 down-regulated miRNAs in the crypt cells of the jejunum. Read More

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http://link.springer.com/10.1007/s11427-018-9338-9
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http://dx.doi.org/10.1007/s11427-018-9338-9DOI Listing
April 2019
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Association between SLC2A9 Genetic Variants and Risk of Hyperuricemia in a Uygur Population.

Curr Med Sci 2019 Apr 23;39(2):243-249. Epub 2019 Apr 23.

The Key Laboratory of Metabolic Diseases, Department of Education, Xinjiang Uygur Autonomous Region and the First Affiliated Hospital, Xinjiang Medical University, Urumqi, 830054, China.

EN: Summary]This study aimed to test the effects of five single nucleotide polymorphisms within SLC2A9 on uric acid level in a special ethnic population, the Uygurs in Xinjiang, China. According to our inclusion and exclusion criteria, Uygur adults from Xinjiang constituted the study population. There were 1053 Uygur adults with hyperuricemia and 1373 normal Uygur adults who served as controls. Read More

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http://link.springer.com/10.1007/s11596-019-2026-2
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http://dx.doi.org/10.1007/s11596-019-2026-2DOI Listing
April 2019
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Notoginseng Saponin Rg1 Prevents Cognitive Impairment through Modulating APP Processing in Aβ-injected Rats.

Curr Med Sci 2019 Apr 23;39(2):196-203. Epub 2019 Apr 23.

Cell Molecular Biology Laboratory of Basic Medical College, Hubei University of Chinese Medicine, Wuhan, 430065, China.

With the intensification of the aging process of the world, Alzheimer's disease (AD), which is the main type of senile dementia, has become a primary problem in the present society. Lots of strategies have been used to prevent and treat AD in animal models and clinical trials, but most of them ended in failure. Panax notoginseng saponins (PNS) contain a variety of monomer compositions which have been separated and identified. Read More

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http://dx.doi.org/10.1007/s11596-019-2019-1DOI Listing

Placental Origins of Preeclampsia: Potential Therapeutic Targets.

Curr Med Sci 2019 Apr 23;39(2):190-195. Epub 2019 Apr 23.

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 4300030, China.

Preeclampsia (PE) remains a leading cause of maternal and perinatal morbidity and mortality in obstetrics worldwide. No effective treatments to reduce its incidence and severity in clinical practice are currently available. A variety of hypotheses have been generated aiming to explain the origins of PE, notably being the genetic predispositions and placental dysfunction. Read More

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http://dx.doi.org/10.1007/s11596-019-2018-2DOI Listing

Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice.

Basic Res Cardiol 2019 Apr 23;114(3):26. Epub 2019 Apr 23.

Institute of Molecular Cell Biology, Jena University Hospital, Friedrich Schiller University, Hans-Knöll-Straße 2, 07745, Jena, Germany.

Sepsis-induced myocardial depression (SIMD) is an early and frequent consequence of the infection-induced systemic inflammatory response syndrome. In homiotherms, variations in ambient temperature (T) outside the thermoneutral zone induce thermoregulatory responses mainly driven by a gradually increased sympathetic activity, which may affect disease severity. We hypothesized that thermoregulatory responses upon reduced T exposition aggravate SIMD in mice. Read More

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http://dx.doi.org/10.1007/s00395-019-0734-1DOI Listing

Clinical T categorization in stage IA lung adenocarcinomas: prognostic implications of CT display window settings for solid portion measurement.

Eur Radiol 2019 Apr 23. Epub 2019 Apr 23.

Department of Radiology, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

Objectives: Our study aimed at evaluating the prognostic implications of lung and mediastinal CT display window settings for solid portion measurements on the eighth-edition lung cancer staging system's clinical T (cT) categorization.

Methods: We retrospectively analyzed 691 surgically treated patients from 2009 to 2015 for clinical stage IA lung adenocarcinomas. Solid portions were measured at the lung and mediastinal window settings, respectively, and cT categories were determined for each measurement (cT and cT). Read More

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http://dx.doi.org/10.1007/s00330-019-06216-6DOI Listing

Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols.

Eur J Nutr 2019 Apr 16. Epub 2019 Apr 16.

Department of Basic and Clinical Sciences, University of Nicosia Medical School, 21 Ilia Papakyriakou, 2414 Engomi, P.O. Box 24005, 1700, Nicosia, Cyprus.

Despite significant advances in the diagnosis and treatment of cancer, the latter still remains a fatal disease due to the lack of prevention, early diagnosis, and effective drugs. Radiotherapy, chemotherapy, and surgery are not only expensive but produce a number of side effects that are detrimental to the patients' quality of life. Therefore, there is a great need to discover anti-cancer therapies that are specific to cancer cells and affordable, safe, and well tolerated by the patients. Read More

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http://dx.doi.org/10.1007/s00394-019-01962-1DOI Listing

[Perspectives for nationwide pollen monitoring in Germany].

Authors:

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Apr 23. Epub 2019 Apr 23.

Allergenic pollen are natural, biological airborne particles and the main cause of allergic respiratory diseases. The measurement of allergenic pollen is a required measure in preventive healthcare and indicates changes in the pollen spectrum as to be expected in the context of climate change.The only nationwide pollen measuring network in Germany is operated by the Foundation German Pollen Information Service, however, its continuity and further development (a hybrid system with manual and automated pollen traps) are not financially guaranteed. Read More

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http://dx.doi.org/10.1007/s00103-019-02940-yDOI Listing

Increasing the homologous recombination efficiency of eukaryotic microorganisms for enhanced genome engineering.

Appl Microbiol Biotechnol 2019 Apr 24. Epub 2019 Apr 24.

College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing, 211816, People's Republic of China.

In recent years, eukaryotic microorganisms have been widely applied to offer many solutions for everyday life and have come to play important roles in agriculture, food, health care, and the fine-chemicals industry. However, the complex genetic background and low homologous recombination efficiency have hampered the implementation of large-scale and high-throughput gene editing in many eukaryotic microorganisms. The low efficiency of homologous recombination (HR) not only makes the modification process labor-intensive but also completely precludes the application of many otherwise very useful genome editing techniques. Read More

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http://dx.doi.org/10.1007/s00253-019-09802-2DOI Listing

Does aromaticity account for an enhanced thermodynamic stability? The case of monosubstituted azaborines and the stereoelectronic chameleonism of the NH group.

Phys Chem Chem Phys 2019 Apr 24. Epub 2019 Apr 24.

University of Belgrade, Institute of Chemistry, Technology and Metallurgy - Center for Chemistry, Njegoševa 12, P.O. Box 473, 11000 Belgrade, Serbia.

This work was initiated by the increasing interest in BN/CC isosterism and by the long-lasting interest in the concepts of aromaticity and substituent effects. We have theoretically examined the aromaticity and stability of monosubstituted BN isosters of benzene, the three isomeric azaborines. The results provide insight into the effect of substitution on two basic molecular properties, which are influenced, here, by the substituent effects and by the B/N relationship in the ring. Read More

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http://dx.doi.org/10.1039/c9cp01011dDOI Listing