484,312 results match your criteria Basic & Clinical Pharmacology & Toxicology[Journal]


Phenotypic and Functional Analysis of T Follicular Cells in Common Variable Immunodeficiency.

Int Arch Allergy Immunol 2020 Jun 3:1-13. Epub 2020 Jun 3.

Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, Irvine, California, USA.

Introduction: One of the most frequent abnormalities of B cells in common variable immunodeficiency (CVID) is reduced number of class-switched memory B cells, suggesting an impaired germinal center response. Therefore, due to its pivotal role in regulating the development of humoral immunity, the objective of this study was to evaluate the role of circulating T follicular helper (cTFH) and circulating T follicular regulatory (cTFR) cells in the pathogenesis of CVID.

Methods: cTFH and cTFR cells from CVID patients and healthy subjects were phenotypically characterized by flow cytometry. Read More

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http://dx.doi.org/10.1159/000507995DOI Listing

Head orientation and gait stability in young adults, dancers and older adults.

Gait Posture 2020 May 25;80:68-73. Epub 2020 May 25.

Bioengineering and Biomechanics Laboratory, Federal University of Goiás, Goiânia, Brazil.

Background: Control of body orientation requires head motion detection by the vestibular system and small changes with respect to the gravitational acceleration vector could cause destabilization.

Research Question: We aimed to compare the effects of different head orientations on gait stability in young adults, dancers and older adults.

Methods: Three groups of 10 subjects were evaluated, the first composed of young adults (aged 18-30 years), the second composed of young healthy dancers under high performance dance training (aged 18-30 years), and the third group composed of community-dwelling older adults (aged 65-80 years). Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.035DOI Listing

Molecular Characteristics and Clinical Outcomes of EGFR Exon 19 C-Helix Deletion in Non-Small Cell Lung Cancer and Response to EGFR TKIs.

Transl Oncol 2020 May 31;13(9):100791. Epub 2020 May 31.

Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, People's Republic of China. Electronic address:

Epidermal growth factor receptor (EGFR) exon 19 deletion (E19del) is the most common activating mutation in advanced non-small cell lung cancer (NSCLC) and associates with the sensitivity of EGFR tyrosine kinase inhibitors (TKIs) treatment. However, not all mutant patterns of E19del have been well studied for the limited coverage of regular EGFR mutation testing. Here, we performed a retrospective cohort study of the C-helix E19del in advanced NSCLC patients based on the screening data by the next-generation sequencing (NGS) platform. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100791DOI Listing

The state of national electronic prescription systems in the EU in 2018 with special consideration given to interoperability issues.

Authors:
Jan Bruthans

Int J Med Inform 2020 May 28;141:104205. Epub 2020 May 28.

Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Czech Republic; Department of Anesthesiology and Intensive Care, First Faculty of Medicine, Charles University in Prague and General Teaching Hospital in Prague, Czech Republic. Electronic address:

Introduction: The electronic prescribing system (EPS) is now widely used in the USA and largely also in EU member countries. Nevertheless, comparisons of different EPS are very scarce. Whilst the EU strives for cross-border interoperability in healthcare, the aim of this study is to provide a contemporary account of the state of national EPS in such countries. Read More

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http://dx.doi.org/10.1016/j.ijmedinf.2020.104205DOI Listing

Racial/ethnic Disparities and Survival in Pediatrics with Gliomas Based on the Surveillance Epidemiology and End Results Database in the United States.

World Neurosurg 2020 May 31. Epub 2020 May 31.

Department of Biochemistry and Molecular Biology, College of Basic Medical, Navy Medical University, Shanghai, 200433, P.R.China. Electronic address:

Background: Gliomas are the most common type of primary central nervous system tumor for both children and adults. But the influence of racial/ethnic disparities on the survival of children with gliomas has not been fully evaluated yet.

Methods: Baseline characteristics of patients, including gender, year of diagnosis, surgery, grade, radiation, histology and races, were collected. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.224DOI Listing

Targeting metabolic syndrome with phytochemicals: Focus on the role of molecular chaperones and hormesis in drug discovery.

Pharmacol Res 2020 May 31:104925. Epub 2020 May 31.

Truba Institute of Pharmacy, Karond-Gandhi Nagar, By Pass Road, Bhopal, 462038, India. Electronic address:

Adaptive cellular stress response confers stress tolerance against inflammatory and metabolic disorders. In response to metabolic stress, the key mediator of cellular adaptation and tolerance is a class of molecules called the molecular chaperones (MCs). MCs are highly conserved molecules that play critical role in maintaining protein stability and functionality. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104925DOI Listing

Oroxylin A suppresses ACTN1 expression to inactivate cancer-associated fibroblasts and restrain breast cancer metastasis.

Pharmacol Res 2020 May 31:104981. Epub 2020 May 31.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China. Electronic address:

Tumor initiation and progression are not only ascribed to the behavior of cancer cells, but also profoundly influenced by the tumor microenvironment. Inside, cancer-associated fibroblasts (CAFs) have become key factors to accelerate growth and metastasis for the abundance in most solid tumors. Our group previously reported that Oroxylin A (OA), a flavone from Scutellaria Baicalensis Georgi, possess the ability to suppress growth and invasion of several tumor cells. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104981DOI Listing

Linking Bodily, Environmental and Mental States In the Self - A Three-level Model Based on A Meta-analysis.

Neurosci Biobehav Rev 2020 May 31. Epub 2020 May 31.

Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada; Mental Health Centre, Zhejiang University School of Medicine, Hangzhou, China.

Current researchers mostly agree that the self consists of both bodily and non-bodily environmental information. The neural mechanism underlying the integration of this information remains unclear. In this study, we propose a neural model subdividing self-processing into three intimately connected levels with different extension: Interoceptive-processing, Exteroceptive-processing and Mental-self-processing. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2020.05.004DOI Listing

Functional Divergence of the Arabidopsis Florigen-Interacting bZIP Transcription Factors FD and FDP.

Cell Rep 2020 Jun;31(9):107717

Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829 Cologne, Germany. Electronic address:

Flowering of many plant species depends on interactions between basic leucine zipper (bZIP) transcription factors and systemically transported florigen proteins. Members of the genus Arabidopsis contain two of these bZIPs, FD and FDP, which we show have largely complementary expression patterns in shoot apices before and during flowering. CRISPR-Cas9-induced null mutants for FDP flower slightly earlier than wild-type, whereas fd mutants are late flowering. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107717DOI Listing

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera.

Cell 2020 May 28. Epub 2020 May 28.

Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China. Electronic address:

Early detection and effective treatment of severe COVID-19 patients remain major challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID-19 and 53 control individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a training cohort of 18 non-severe and 13 severe patients. Read More

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http://dx.doi.org/10.1016/j.cell.2020.05.032DOI Listing

Structural variations and expression profiles of the SARS-CoV-2 host invasion genes in Lung cancer.

J Med Virol 2020 Jun 3. Epub 2020 Jun 3.

Nigde Omer Halisdemir University, Faculty of Medicine, Department of Medical Biology, Nigde, Turkey.

Recent days have seen growing evidence of cancer's susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and of the effect of genomic differences on the virus' entrance genes in lung cancer. Genetic confirmation of the hypotheses regarding gene expression and mutation pattern of target genes, including Angiotensin Converting Enzyme-2 (ACE2), Transmembrane Serine Protease 2 (TMPRSS2), Basigin (CD147/BSG) and Paired Basic Amino Acid Cleaving Enzyme (FURIN/PCSK3), as well as correlation analysis, were evaluated in lung adenocarcinoma (LUAD) and lung squamous carcinoma (LUSC) using in silico analysis. Not only were gene expression and mutation patterns detected, but also there was a correlation and survival analysis between ACE2 and other target genes expression levels. Read More

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http://dx.doi.org/10.1002/jmv.26107DOI Listing

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial.

JAMA 2020 Jun 3. Epub 2020 Jun 3.

Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China.

Importance: Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from randomized clinical trials are needed.

Objective: To evaluate the efficacy and adverse effects of convalescent plasma therapy for patients with COVID-19.

Design, Setting, And Participants: Open-label, multicenter, randomized clinical trial performed in 7 medical centers in Wuhan, China, from February 14, 2020, to April 1, 2020, with final follow-up April 28, 2020. Read More

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http://dx.doi.org/10.1001/jama.2020.10044DOI Listing

Polymorphism analysis of miR182 and CDKN2B genes in Greek patients with primary open angle glaucoma.

PLoS One 2020 3;15(6):e0233692. Epub 2020 Jun 3.

Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Glaucoma is a progressive optic neuropathy resulting from retinal ganglion cells death; it represents one of the leading causes of irreversible blindness worldwide. Although, primary open angle glaucoma (POAG) is the most common type of the disease, the pathogenesis of POAG and the genetic factors contributing to disease development remain poorly understood. The aim of this study was to investigate whether the polymorphisms rs76481776 in miR182 gene and rs3217992 in cyclin-dependent kinase inhibitor-2B (CDKN2B) gene are risk factors for POAG in a series of patients of Greek origin. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233692PLOS

[The pH-Sensitive Potassium Channel TASK-1 Is a Chemosensor for Central Respiratory Regulation in Rats].

Mol Biol (Mosk) 2020 May-Jun;54(3):457-468

Department of Basic Medical Sciences, School of Medical, Shihezi University, Shihezi, 832000 China.

TWIK-related acid-sensitive potassium channel-1 (TASK-1) is a "leak" potassium channel sensitive to extracellular protons. It contributes to setting the resting potential in mammalian neurons. TASK-1 channels are widely expressed in respiratory-related neurons in the central nervous system. Read More

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http://dx.doi.org/10.31857/S0026898420030106DOI Listing
September 2019

[Prospective Applications of Single-Domain Antibodies in Biomedicine].

Authors:
S V Tillib

Mol Biol (Mosk) 2020 May-Jun;54(3):362-373

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia.

Methods that utilize highly specific antibodies, anti-idiotypic antibodies, various recombinant molecules with antibody properties and immunocorrection and immunoprophylaxis with the help of vaccines are in demand and are intensely developed in the field of biomedicine. Techniques to generate specific single-domain recombinant antibodies (nanobodies) and their derivatives have raised great expectations in the past years. The review considers the recent literature data on the use of nanobodies in basic research, diagnosis, and design of new immunotherapeutic agents. Read More

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http://dx.doi.org/10.31857/S0026898420030167DOI Listing

The Effect of Shen Qi Wan Medicated Serum on NRK-52E Cells Proliferation and Migration by Targeting Aquaporin 1 (AQP1).

Med Sci Monit 2020 Jun 3;26:e922943. Epub 2020 Jun 3.

College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China (mainland).

BACKGROUND Shen Qi Wan (SQW) as a well-known formula for the amelioration of kidney yang deficiency syndrome (KYDS), and it has been widely employed in traditional Chinese medicine (TCM). This study aimed to investigate the effect and underlying mechanism of SQW medicated serum on proliferation and migration in NRK-52E cells. MATERIAL AND METHODS We employed the real-time cell analysis (RTCA) system to investigate the effect of SQW medicated serum on proliferation and migration in NRK-52E cells. Read More

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http://dx.doi.org/10.12659/MSM.922943DOI Listing

The common pathophysiologic threads between Asian Indian diabetic's 'Thin Fat Phenotype' and partial lipodystrophy: the peripheral adipose tissue transcriptomic evidences.

Adipocyte 2020 Jan;9(1):253-263

Department of Endocrinology, Sawai Man Singh Medical College and Hospital , Jaipur, India.

T2D is a complex disease with poorly understood mechanisms. In Asian Indians, it is associated with "thin fat" phenotype which resembles with partial lipodystrophy. We hypothesized that disturbed expression of lipodystrophy genes might play a role in T2D pathogenesis. Read More

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http://dx.doi.org/10.1080/21623945.2020.1776082DOI Listing
January 2020

Entropy production and fluctuation theorems on complex networks.

Chaos 2020 May;30(5):053125

CCSS, CTP and Department of Physics and Astronomy, Seoul National University, Seoul 08826, South Korea.

Entropy production (EP) is a fundamental quantity useful for understanding irreversible process. In stochastic thermodynamics, EP is more evident in probability density functions of trajectories of a particle in the state space. Here, inspired by a previous result that complex networks can serve as state spaces, we consider a data packet transport problem on complex networks. Read More

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http://dx.doi.org/10.1063/1.5143031DOI Listing

PM2.5 promotes apoptosis of alveolar epithelial cells via targeting ROS/p38 signaling pathway and thus leads to emphysema in mice.

Minerva Med 2020 Jun 2. Epub 2020 Jun 2.

Cell Signal Transduction Laboratory and Institute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng, China -

Background: To uncover the ability of PM2.5 exposure to induce apoptosis in alveolar epithelial cells by stimulating excessive production of reactive oxygen species (ROS), thus activating p38 to result in emphysema in mice.

Methods: Male BALB / c mice with 6-8-week-old were exposed to 200 TPM mg/L PM2. Read More

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http://dx.doi.org/10.23736/S0026-4806.20.06652-5DOI Listing

Isoimperatorin reduces the effective dose of dexamethasone in a murine model of asthma by inhibiting mast cell activation.

Phytother Res 2020 Jun 3. Epub 2020 Jun 3.

College of Pharmacy, Xi'an Jiaotong University, Xi'an, China.

Adverse effects that result from dexamethasone (DEX) use are common and serious in patients with asthma. Therefore, alternative anti-inflammatory treatments are being investigated. Isoimperatorin (ISO), an active natural furocoumarin, possesses multiple pharmacological properties, including an anti-inflammation effect. Read More

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http://dx.doi.org/10.1002/ptr.6726DOI Listing

Resveratrol targeting tau proteins, amyloid-beta aggregations, and their adverse effects: An updated review.

Phytother Res 2020 Jun 3. Epub 2020 Jun 3.

College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

Resveratrol (Res) is a non-flavonoid compound with pharmacological actions such as antioxidant, antiinflammatory, hepatoprotective, antidiabetes, and antitumor. This plant-derived chemical has a long history usage in treatment of diseases. The excellent therapeutic impacts of Res and its capability in penetration into blood-brain barrier have made it an appropriate candidate in the treatment of neurological disorders (NDs). Read More

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http://dx.doi.org/10.1002/ptr.6732DOI Listing

Influence of acid-base dissociation equilibria during electromembrane extraction.

J Sep Sci 2020 Jun 3. Epub 2020 Jun 3.

Department of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, Oslo, 0316, Norway.

Electromembrane extraction is affected by acid-base equilibria of the extracted substances as well as coupled equilibria associated with the partitioning of neutral substances to the supported liquid membrane. A theoretical model for this was developed and verified experimentally in the current work using pure 2-nitrophenyl octyl ether as supported liquid membrane. From this model, extraction efficiency as a function of pH can be predicted. Read More

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http://dx.doi.org/10.1002/jssc.202000391DOI Listing

Patient experience in co-production of care: perceptions about patient safety protocols.

Rev Lat Am Enfermagem 2020 1;28:e3272. Epub 2020 Jun 1.

Escola de Enfermagem, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Objective: to analyze the experience of the patient during hospitalization, focusing on the co-production of care related to patient safety protocols.

Method: qualitative study, whose data were collected through the triangulation of multiple sources: document analysis, observation of 10 professionals in the provision of care and 24 interviews with patient-families from 12 clinical and surgical inpatient units of a hospital. Thematic analysis was carried out, based on the concept of co-production. Read More

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http://dx.doi.org/10.1590/1518-8345.3352.3272DOI Listing

Sensory and cognitive functions, gait ability and functionality of older adults.

Rev Lat Am Enfermagem 2020 1;28:e3282. Epub 2020 Jun 1.

Facultad de Organización Deportiva, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Nuevo León, Mexico.

Objective: to know the relationship between the sensory function, gait ability, and cognitive function with dependency in older adults.

Method: a descriptive cross-sectional design, 146 older adults took part.

Measurements: Snellen chart, Audiometer, Stereognosia tests, Semmes-Weinstein monofilament, basic aromas and flavors, GAITRite system, Montreal Cognitive Assessment Test, the Barthel Index, and the Lawton and Brody Index. Read More

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http://dx.doi.org/10.1590/1518-8345.3499.3282DOI Listing

Nurse Navigator: development of a program for Brazil.

Rev Lat Am Enfermagem 2020 1;28:e3275. Epub 2020 Jun 1.

Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.

Objective: to develop a Navigation Program for cancer patients, based on the model proposed by The GW Cancer Institute at George Washington University, adapted to the reality of a Brazilian High Complexity Center in Oncology.

Method: a convergent care research applied in the development of a patient navigation care process, based on the model proposed by George Washington University, adapted for a High Complexity Center in Oncology in Brazil. Phases of the Convergent Assistance Research: conception, instrumentation, scrutiny, analysis and interpretation. Read More

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http://dx.doi.org/10.1590/1518-8345.3258.3275DOI Listing

Depression as a mediator between intimate partner violence and postpartum sexual issues: a structural analysis.

Rev Bras Epidemiol 2020 1;23:e200048. Epub 2020 Jun 1.

Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Bristol, United Kingdom.

Introduction: No studies were found that evaluate the association between intimate partner violence (IPV) before childbirth and sexual issues in the postpartum period.

Method: A cross-sectional study with 700 women who received prenatal care in a basic health unit in São Paulo, between 2006 and 2007. Sexual issues were assessed through a questionnaire created by the authors, and intimate partner violence was evaluated using a structured questionnaire developed by the WHO. Read More

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http://dx.doi.org/10.1590/1980-549720200048DOI Listing

The trauma and acute care surgeon in the COVID-19 pandemic era.

Rev Col Bras Cir 2020 29;47:e20202576. Epub 2020 May 29.

Grupo Surgical, Campinas, SP, Brasil.

The World Health Organization recognized in March 2020 the existence of a pandemic for the new coronavirus that appeared in China, in late 2019, and whose disease was named COVID-19. In this context, the SBAIT (Brazilian Society of Integrated Care for Traumatized Patients) conducted a survey with 219 trauma and emergency surgeons regarding the availability of personal protective equipment (PPE) and the role of the surgeon in this pandemic by means of an electronic survey. It was observed that surgeons have been acting under inadequate conditions, with a lack of basic supplies as well as more specific equipment such as N95 masks and facial shields for the care of potential victims who may be contaminated. Read More

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http://dx.doi.org/10.1590/0100-6991e-20202576DOI Listing

Structural and procedural conditions in National Immunization Program Information System establishment.

Rev Bras Enferm 2020 1;73(4):e20180939. Epub 2020 Jun 1.

Universidade Federal de São João Del Rei, Divinópolis, Minas Gerais, Brazil.

Objectives: to analyze structural and process conditions in National Immunization Program Information System establishment.

Methods: a cross-sectional study conducted in 307 vaccination rooms in the state of Minas Gerais in 2017. For data collection, a multidimensional questionnaire was used. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0939DOI Listing

Primary care mental health: nurses' activities in the psychosocial care network.

Rev Bras Enferm 2020 1;73 Suppl 1:e20190104. Epub 2020 Jun 1.

Centro Universitário Uninovafapi, Teresina, Piauí, Brazil.

Objective: to describe and analyze the role of expert nurses in mental health in the Family Health Strategy.

Method: a qualitative study, with 20 Basic Health Units nurses of Teresina, Piauí. The information was collected through semi-structured interviews from March to May 2017 and analyzed using the content analysis method. Read More

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http://dx.doi.org/10.1590/0034-7167-2019-0104DOI Listing

Health literacy and depression in women with type 2 diabetes mellitus.

Clinics (Sao Paulo) 2020 29;75:e1436. Epub 2020 May 29.

College of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.

Objectives: The prevalence of diabetes mellitus has recently increased in Taiwan, and depression is common among these patients. Moreover, a lack of health literacy may lead to depression. In this study, we explored the correlation between health literacy and depression in diabetic women. Read More

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http://dx.doi.org/10.6061/clinics/2020/e1436DOI Listing

An MRI contrast agent based on a zwitterionic metal-chelating polymer for hepatorenal angiography and tumor imaging.

J Mater Chem B 2020 Jun 3. Epub 2020 Jun 3.

Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Bei Yi Jie 2, Zhong Guan Cun, Beijing 100190, China. and School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.

MRI contrast agents such as paramagnetic Gd(iii)-chelates, can improve the ability of MRI in differentiating diseased and healthy tissues, and have been widely used in clinical diagnosis. However, the enhancement effect of small molecular MRI contrast agents is unsatisfied due to their relative high rotation rates. Furthermore, the small molecular contrast agents also suffer from the short blood half-life and nonspecific extracellular diffusion in tissues, which also restricts their applications. Read More

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http://dx.doi.org/10.1039/d0tb00893aDOI Listing

Rapid generation of rotavirus single-gene reassortants by means of eleven plasmid-only based reverse genetics.

J Gen Virol 2020 Jun 3. Epub 2020 Jun 3.

Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.

Reassortment is an important mechanism in the evolution of group A rotaviruses (RVAs), yielding viruses with novel genetic and phenotypic traits. The classical methods for generating RVA reassortants with the desired genetic combinations are laborious and time-consuming because of the screening and selection processes required to isolate a desired reassortant. Taking advantage of a recently developed RVA reverse genetics system based on just 11 cloned cDNAs encoding the RVA genome (11 plasmid-only system), we prepared a panel of simian SA11-L2 virus-based single-gene reassortants, each containing 1 segment derived from human KU virus of the G1P[8] genotype. Read More

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http://dx.doi.org/10.1099/jgv.0.001443DOI Listing

Effects of hydric stress on vibrational frequency patterns of plants.

Plant Signal Behav 2020 Jun 3:1770489. Epub 2020 Jun 3.

Physical Metrology, National Metrology Center (CENAM) Km 4.5 Carretera a Los Cues C.P , El Marques, México.

Plants that experience a lack of sufficient irrigation undergo hydric stress, which causes the modification of their mechanical properties. These changes include a complex network of chemical and physical signals that interact between plant-plant and plant-environment systems in a mechanism that is still not well understood, and that differs among species. This mechanical response implies different levels of vibration when the plant experiences structural modifications from self-hydraulic adjustments of flux exchange at specific frequencies, with these carrying behavioral information. Read More

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http://dx.doi.org/10.1080/15592324.2020.1770489DOI Listing

Using concept mapping to explore the challenges associated with affording and accessing medications among people living with HIV in Ontario, Canada.

AIDS Care 2020 Jun 3:1-6. Epub 2020 Jun 3.

Division of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Antiretroviral medications are expensive, and people living with HIV often experience challenges accessing and paying for medication due to various obstacles. We used concept mapping to explore the challenges people living with HIV in Ontario, Canada, face when accessing medication. In brainstorming, 68 participants generated 447 statements in response to the focus prompt "Some people living with HIV have trouble getting and paying for prescription drugs because … ". Read More

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http://dx.doi.org/10.1080/09540121.2020.1770182DOI Listing

The contraceptive potential of Carica papaya seed on oestrus cycle, progesterone, and histomorphology of the Utero-ovarian tissue of adult wistar rats.

JBRA Assist Reprod 2020 Jun 3. Epub 2020 Jun 3.

Department of Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences, Edo University Iyamho, Edo State, Nigeria.

Objective: The study's goal was to ascertain the contraceptive effects of Aqueous extract of Carica papaya on female rats by assessing changes in the body weight, estrous cycle, serum progesterone level and the cyto-architecture of the Utero-ovarian tissue.

Methods: We used twenty (20) healthy young Adult Female Albino rats. The study ran for 7 and 21 days, respectively. Read More

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http://dx.doi.org/10.5935/1518-0557.20200023DOI Listing

Inhibitory mechanism of epicatechin gallate on tyrosinase: inhibitory interaction, conformational change and computational simulation.

Food Funct 2020 Jun 3. Epub 2020 Jun 3.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.

The inhibition mechanism of epicatechin gallate (ECG) on tyrosinase was investigated by multispectroscopic techniques combined with molecular docking and molecular dynamics simulation. The results demonstrated that ECG suppressed the activity of tyrosinase in a reversible mixed-inhibition with a half inhibitory concentration (IC50) of (1.13 ± 0. Read More

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http://dx.doi.org/10.1039/d0fo00003eDOI Listing

Nanomaterial-based multiplex optical sensors.

Analyst 2020 Jun 3. Epub 2020 Jun 3.

Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, P. R. China.

The drive for a simultaneous analysis of multiple targets with excellent accuracy and efficiency, which is often required in both basic biomedical research and clinical applications, demands the development of multiplexed bioassays with desired throughput. With the development of nanotechnologies, innovative multiplex optical bioassays have been achieved. Nanomaterials exhibit unique physical and chemical properties such as easily tunable size, large surface-to-volume ratio, excellent catalysis and the desired signal transduction mechanism, which makes them excellent candidates for the fabrication of novel optical nanoprobes. Read More

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http://dx.doi.org/10.1039/d0an00392aDOI Listing