443,600 results match your criteria Basic & Clinical Pharmacology & Toxicology[Journal]


DIY Automated Feeding and Motion Recording System for the Analysis of Fish Behavior.

SLAS Technol 2019 Apr 23:2472630319841412. Epub 2019 Apr 23.

2 Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany.

Fish species such as medaka or zebrafish are widely used as animal models to study physiology, disease development, and treatment efficacy. They are also used to study the rapidly growing field of behavior research, such as social interactions, anxiety, and the influence of environmental factors. Here we describe an automated experimental setup allowing the recording of general locomotor activity in combination with a food-on-demand system. Read More

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http://dx.doi.org/10.1177/2472630319841412DOI Listing

Vocal Development in Infants and Toddlers With Bilateral Cochlear Implants and Infants With Normal Hearing.

J Speech Lang Hear Res 2019 Apr 22:1-13. Epub 2019 Apr 22.

Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN.

Purpose The purpose of this study was to investigate the time course of vocal development in infants and toddlers with bilateral cochlear implants (CIs; bilateral CI group) who are acquiring Finnish and to compare their progress to that of infants with normal hearing and typical development (TD group). Method Five thousand nine hundred sixty-four spontaneous utterances of 30 infants and toddlers (15 in both groups) were classified as either precanonical (PC) vocalizations, basic canonical syllables (BCS), or advanced forms (AF) levels. Time course of development and group differences were analyzed in a prospective longitudinal study during a time course of 1 year: before implantation and 1, 3, 6, 9, and 12 months after CI activation for the bilateral CI group and at 6, 9, and 12 months of age for the TD group. Read More

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http://dx.doi.org/10.1044/2018_JSLHR-S-18-0260DOI Listing

Effect of Distal Esophageal Irritation on the Changes of Cystometry Parameters to Esophagus and Colon Distentions in Rats.

Authors:
Ezidin Kaddumi

Can J Physiol Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Al-Balqa' Applied University, 59303, Basic Medical Sciences , P. O. Box 206 , Al-Salt, Jordan , 19117.

The coexistence of different visceral pathologies on patients suffering from irritable bowel syndrome, interstitial cystitis, and other pathologies, necessitates the study of theses pathologies under complicated conditions. In the present study, cystometry recordings were used to investigate the effect of distal esophageal chemical irritation (DEI) on the urinary bladder interaction with distal colon distention (DCD), distal esophageal distention (DED), and electrical stimulation of abdominal branches of vagus nerve (abd-vagus). DEI significantly decreased the intercontraction time (ICT) via decreasing the voiding time (VT). Read More

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http://dx.doi.org/10.1139/cjpp-2019-0122DOI Listing

Spirometry: basic concepts.

Rev Alerg Mex 2019 Jan-Mar;66(1):76-84

Benemérita Universidad Autónoma de Puebla, Hospital Universitario de Puebla, Puebla, México.

Spirometry is a pulmonary function test that allows screening, diagnosis and monitoring of respiratory diseases. This is a simple, non-invasive test that is easy to perform. By quantifying the respiratory volumes and flows, such as forced vital capacity (FVC) or forced expiratory volume in six seconds (FEV6), forced expiratory volume in the first second (FEV1), and the relationship between these parameters (FEV1/FVC or FEV1/FEV6 ratio), obstruction can be detected with high sensitivity and specificity; likewise, it is possible to classify the severity and response to the bronchodilator. Read More

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http://dx.doi.org/10.29262/ram.v66i1.536DOI Listing

Construct Cyan Fluorescence by De Novo Tripeptides: An In Vitro Mutation Study on the Role of Single Amino Acid Residues and Their Sequence.

Chembiochem 2019 Apr 23. Epub 2019 Apr 23.

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China., Yuexiu Road, CHINA.

Amino acids are a natural choice as building blocks for developing bio-functional entities owing to their superior diversity and versatile physicochemical properties compared to nucleotide bases. A simple permutation of amino acids creates a broad palette of proteins that are successfully engineered as useful bio-functional agents. For example, the intrinsic ultraviolet fluorescence of phenylalanine (F) and tryptophan (W) have been engineered to emit in the visible spectrum [1, 2], that has broad applications as imaging/sensing probes, photothermal therapy agents, optogenetic switches, etc. Read More

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http://dx.doi.org/10.1002/cbic.201900166DOI Listing

Parent and child perception of quality of life in a randomized controlled peanut oral immunotherapy trial.

Pediatr Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.

Background: Improved quality of life (QoL) after oral immunotherapy (OIT) in peanut allergic children is often reported by their parents, while the child's perspective is less clear.

Objective: We aimed to explore if two years of OIT improved QoL in children with peanut allergy and to identify factors influencing change in QoL.

Methods: In the open labelled TAKE-AWAY peanut OIT trial including children with anaphylaxis to peanuts, 57 were randomized to OIT and 20 to observation. Read More

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http://dx.doi.org/10.1111/pai.13066DOI Listing

Rare cancers in childhood and adolescence in Brazil: First report of data from 19 population-based cancer registries.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

IRCCS Foundation, Evaluative Epidemiology Unit, Evaluative Epidemiology Unit, National Cancer Institute, Milan, Italy.

Background: Rare childhood cancer is challenging to define. The Italian Pediatric Rare Tumor (TREP) Study considers rare tumors to include solid malignancies characterized by an annual incidence rate of <2 cases per 1 million and not enrolled in clinical trials. The objective of the current study was to analyze the population incidence rate of rare tumors among children and adolescents (those aged birth-19 years) in Brazil. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32121
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http://dx.doi.org/10.1002/cncr.32121DOI Listing
April 2019
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Crystal Structure and Photoluminescence Properties of an Incommensurate Phase in EuO- and PO-Doped CaSiO.

Inorg Chem 2019 Apr 23. Epub 2019 Apr 23.

Department of Life Science and Applied Chemistry , Nagoya Institute of Technology , Nagoya 466-8555 , Japan.

We have for the first time clarified the incommensurately modulated crystal structure as well as the photoluminescence properties of Eu-activated CaSiO solid solution, the chemical formula of which is (CaEu□)(SiP)O, where □ denotes vacancies in Ca sites with the replacement of Si by P. The emission spectrum upon the 335 nm excitation showed a relatively broad band centered at ca. 490 nm and a full width at half-maximum of ca. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00408DOI Listing

Characterizing Polymer-Grafted Nanoparticles: From Basic Defining Parameters to Behavior in Solvents and Self-Assembled Structures.

Anal Chem 2019 Apr 23. Epub 2019 Apr 23.

Polymer-grafted nanoparticles, often called hairy nanoparticles (HNPs), are an intriguing class of nanostructured hybrid materials with great potential in a variety of applications, including advanced polymer nanocomposite fabrication, drug delivery, imaging, and lubrication. This Feature Article provides an introduction to characterization of various aspects of HNPs, from basic defining parameters to behavior of HNPs in solvents and self-assembled structures of multicomponent brush nanoparticles, by using a broad range of analytical tools. Read More

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http://dx.doi.org/10.1021/acs.analchem.9b00707DOI Listing

Redox-Active Zeolitic Transition Metal Oxides Based on ε-Keggin Units for Selective Oxidation.

Inorg Chem 2019 Apr 23. Epub 2019 Apr 23.

Faculty of Engineering , Kanagawa University , Rokkakubashi, Kanagawa-ku, Yokohama-shi , Kanagawa 221-8686 , Japan.

The design and development of zeolitic transition metal oxides for selective oxidation are interesting due to the combination of the redox properties and microporosities. Redox-active zeolitic transition metal oxides based on ε-Keggin iron molybdates were synthesized. O can be activated by the materials via an electron-transfer-based process, and the materials can be oxidized even at room temperature. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00502DOI Listing

Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53-altered tumors.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia.

Background: Over 96% of high-grade ovarian carcinomas and 50% of all cancers are characterized by alterations in the p53 gene. Therapeutic strategies to restore and/or reactivate the p53 pathway have been challenging. By contrast, p63, which shares many of the downstream targets and functions of p53, is rarely mutated in cancer. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32053
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http://dx.doi.org/10.1002/cncr.32053DOI Listing
April 2019
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Thulium doped LaF for nanothermometry operating over 1000 nm.

Nanoscale 2019 Apr 23. Epub 2019 Apr 23.

Group of Nano-Photonics and Imaging, Instituto de Física, Universidade Federal de Alagoas, 57072-900, Maceió-AL, Brazil.

The use and applications of infrared emitting rare-earth luminescent nanoparticles as nanothermometers have attracted a great deal of attention during the last few years. Researchers have regarded rare-earth doped luminescent nanoparticles as appealing systems due to their reliability, sensitivity and versatility for minimally invasive thermal sensing in nanomedicine. The challenge of developing nanothermometers operating over 1000 nm with outstanding brightness and enhanced sensitivity is being constantly addressed. Read More

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http://xlink.rsc.org/?DOI=C9NR00082H
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http://dx.doi.org/10.1039/c9nr00082hDOI Listing
April 2019
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Understanding independent wheelchair transfers. Perspectives from stakeholders.

Disabil Rehabil Assist Technol 2019 Apr 23:1-8. Epub 2019 Apr 23.

a University College London Interaction Centre , London , UK.

Purpose: Transferring to and from the wheelchair is among the most important routine tasks for many wheelchair users. Transfers are also greatly affected by many personal and external factors. The purpose of this study is to investigate personal experiences, needs and concerns of wheelchair users in relation to wheelchair transfers performed in their everyday lives. Read More

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http://dx.doi.org/10.1080/17483107.2019.1594407DOI Listing

The Forest and the Trees: Investigating the Globality and Specificity of Employees' Basic Need Satisfaction at Work.

J Pers Assess 2019 Apr 23:1-12. Epub 2019 Apr 23.

a Université de Tours, QualiPsy EE 1901, Tours , France.

This research assessed the underlying psychometric multidimensionality and nomological validity of 523 employees' responses to the Work-related Basic Need Satisfaction (W-BNS) scale using bifactor-exploratory structural equation modeling (bifactor-ESEM). Our results first showed the superiority of a bifactor-ESEM representation when compared to alternative representations of the data. Thus, employees' ratings of psychological need satisfaction simultaneously reflected a global need satisfaction construct, which coexisted with specific autonomy, competence, and relatedness needs satisfaction. Read More

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http://dx.doi.org/10.1080/00223891.2019.1591426DOI Listing

Hybridization-Switching Induced Mott Transition in ABO_{3} Perovskites.

Phys Rev Lett 2019 Jan;122(1):016404

Department of Condensed Matter Physics and Materials Science, S.N. Bose National Centre for Basic Sciences, Kolkata 700098, India.

We propose the concept of a "hybridization-switching induced Mott transition" which is relevant to a broad class of ABO_{3} perovskite materials including BiNiO_{3} and PbCrO_{3} that feature extended 6s orbitals on the A-site cation (Bi or Pb), and a strong A-O covalency induced ligand hole. Using ab initio electronic structure and slave rotor theory calculations, we show that such systems exhibit a breathing phonon driven A-site to oxygen hybridization-wave instability which conspires with strong correlations on the B-site transition metal ion (Ni or Cr) to trigger a Mott insulating state. This class of systems is shown to undergo a pressure induced insulator to metal transition accompanied by a colossal volume collapse due to ligand hybridization switching. Read More

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http://dx.doi.org/10.1103/PhysRevLett.122.016404DOI Listing
January 2019

Laser Acceleration of Highly Energetic Carbon Ions Using a Double-Layer Target Composed of Slightly Underdense Plasma and Ultrathin Foil.

Phys Rev Lett 2019 Jan;122(1):014803

Center for Relativistic Laser Science, Institute for Basic Science, Gwangju 61005, Korea.

We report the experimental generation of highly energetic carbon ions up to 48 MeV per nucleon by shooting double-layer targets composed of well-controlled slightly underdense plasma and ultrathin foils with ultraintense femtosecond laser pulses. Particle-in-cell simulations reveal that carbon ions are ejected from the ultrathin foils due to radiation pressure and then accelerated in an enhanced sheath field established by the superponderomotive electron flow. Such a cascaded acceleration is especially suited for heavy ion acceleration with femtosecond laser pulses. Read More

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http://dx.doi.org/10.1103/PhysRevLett.122.014803DOI Listing
January 2019

State Exchange with Quantum Side Information.

Phys Rev Lett 2019 Jan;122(1):010502

Department of Mathematics and Research Institute for Basic Sciences, Kyung Hee University, Seoul 02447, Korea.

We consider a quantum communication task between two users Alice and Bob, in which Alice and Bob exchange their respective quantum information by means of local operations and classical communication assisted by shared entanglement. Here, we assume that Alice and Bob may have quantum side information, not transferred, and classical communication is free. In this work, we derive general upper and lower bounds for the least amount of entanglement which is necessary to perfectly perform this task, called the state exchange with quantum side information. Read More

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http://dx.doi.org/10.1103/PhysRevLett.122.010502DOI Listing
January 2019

Topological Landscape of Competing Charge Density Waves in 2H-NbSe_{2}.

Phys Rev Lett 2019 Jan;122(1):016403

Center for Artificial Low Dimensional Electronic Systems, Institute for Basic Science (IBS), Pohang 37673, Republic of Korea, and Department of Physics, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea.

Despite decades of studies of the charge density wave (CDW) of 2H-NbSe_{2}, the origin of its incommensurate CDW ground state has not been understood. We discover that the CDW of 2H-NbSe_{2} is composed of two different, energetically competing, structures. The lateral heterostructures of two CDWs are entangled as topological excitations, which give rise to a CDW phase shift and the incommensuration without a conventional domain wall. Read More

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http://dx.doi.org/10.1103/PhysRevLett.122.016403DOI Listing
January 2019

First Direct Search for Inelastic Boosted Dark Matter with COSINE-100.

Phys Rev Lett 2019 Apr;122(13):131802

Department of Physics, Sungkyunkwan University, Suwon 16419, Republic of Korea.

A search for inelastic boosted dark matter (IBDM) using the COSINE-100 detector with 59.5 days of data is presented. This relativistic dark matter is theorized to interact with the target material through inelastic scattering with electrons, creating a heavier state that subsequently produces standard model particles, such as an electron-positron pair. Read More

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http://dx.doi.org/10.1103/PhysRevLett.122.131802DOI Listing

NbALD1 mediates resistance to turnip mosaic virus by regulating the accumulation of salicylic acid and the ethylene pathway in Nicotiana benthamiana.

Mol Plant Pathol 2019 Apr 23. Epub 2019 Apr 23.

The State Key Laboratory Breeding Base for Sustainable Control of Pest and Disease, Key Laboratory of Biotechnology in Plant Protection of MOA of China and Zhejiang Province, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, China.

AGD2-LIKE DEFENCE RESPONSE PROTEIN 1 (ALD1) triggers plant defence against bacterial and fungal pathogens by regulating the salicylic acid (SA) pathway and an unknown SA-independent pathway. We now show that Nicotiana benthamiana ALD1 is involved in defence against a virus and that the ethylene pathway also participates in ALD1-mediated resistance. NbALD1 was up-regulated in plants infected with turnip mosaic virus (TuMV). Read More

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http://dx.doi.org/10.1111/mpp.12808DOI Listing

Which Nanobasics Should Be Taught in Medical Schools?

AMA J Ethics 2019 Apr 1;21(4):E337-346. Epub 2019 Apr 1.

The Walter J. Hamlin Professor of Dermatology and chair of the Department of Dermatology at Northwestern University Feinberg School of Medicine in Chicago, Illinois, where she also serves as the director of the Skin Disease Research Center.

The progressive growth in nanotechnology approaches to diagnostics and therapeutics, especially for cancer, necessitates training physicians in nanoethics. This article explains why it is critical for medical education to include instruction in nanotechnology, nanomedicine, nanotoxicology, and nanoethics and suggests basic concepts educators can use to infuse curricula with this content. Read More

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http://dx.doi.org/10.1001/amajethics.2019.337DOI Listing

Update on Mechanisms of Adaptive Resistance to Immune Check Point Blockers in Malignancies: A Short Commentary.

Curr Pharm Des 2019 ;24(45):5349-5351

Department of Basic Medical Sciences, Neuroscience and Sensory Organs, School of Medicine, University of Bari, Bari, Italy.

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http://dx.doi.org/10.2174/138161282445190416154917DOI Listing
January 2019

Tactile sensitivity, tactile acuity, and affective touch: from childhood to early adolescence.

Somatosens Mot Res 2019 Apr 23:1-7. Epub 2019 Apr 23.

b Department of Psychology , Sapienza University of Rome , Rome , Italy.

The development of somatosensation and affective touch acquires a central role throughout our lives, for several reasons. In adults, these functions are driven by different, neuroanatomically and functionally segregated fibres. To date, very little is known about the basic features of these fibres in childhood and this lack of knowledge is mirrored in the affective touch domain, where there are no studies on the main physiological features of the tactile processes linked to the stimulation of the hairy skin, namely the preferential site of affective touch. Read More

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http://dx.doi.org/10.1080/08990220.2019.1604334DOI Listing

MicroRNA-31 Negatively Regulates Interleukin-34 Expression In Vitro.

Immunol Invest 2019 Apr 23:1-11. Epub 2019 Apr 23.

d Department of Basic and Clinical Pharmacology, School of Pharmacy , Anhui Medical University , Hefei , Anhui Province , P.R.China.

Interleukin-34 (IL-34) is a recently discovered cytokine that promotes tissue macrophage maturation and differentiation. We previously found that 1α,25-Dihydroxyvitamin D3 up-regulated IL-34 expression in SH-SY5Y neural cells. However, whether microRNA regulates IL-34 expression is not completely clear. Read More

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http://dx.doi.org/10.1080/08820139.2019.1578230DOI Listing

Flavonoids in a crude extract of Catha edulis inhibit rat intestinal contraction via blocking Ca channels.

Neurogastroenterol Motil 2019 Apr 23:e13602. Epub 2019 Apr 23.

Department of Physiology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, China.

Background: Animal studies show that Catha edulis inhibits gastrointestinal tract motility. However, there is little or no information on its effect on colon motility and the mechanism of action and active constituents responsible for this effect. This study therefore attempted to discern the effect, suggest the mechanism, and identify the active compounds from the crude extract. Read More

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http://dx.doi.org/10.1111/nmo.13602DOI Listing

ERα is required for suppressing OCT4-induced proliferation of breast cancer cells via DNMT1/ISL1/ERK axis.

Cell Prolif 2019 Apr 22:e12612. Epub 2019 Apr 22.

The Key Laboratory of Pathology, Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China.

Objective: POU5F1 (OCT4) is implicated in cancer stem cell self-renewal. Currently, some studies have shown that OCT4 has a dual function in suppressing or promoting cancer progression. However, the precise molecular mechanism of OCT4 in breast cancer progression remains unclear. Read More

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http://dx.doi.org/10.1111/cpr.12612DOI Listing

Light-Triggered In Situ Gelation to Enable Robust Photodynamic-Immunotherapy by Repeated Stimulations.

Adv Mater 2019 Apr 22:e1900927. Epub 2019 Apr 22.

Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China.

Photodynamic therapy (PDT) has shown the potential of triggering systemic antitumor immune responses. However, while the oxygen-deficient hypoxic tumor microenvironment is a factor that limits the PDT efficacy, the immune responses after conventional PDT usually are not strong enough to eliminate metastatic tumors. Herein, a light-triggered in situ gelation system containing photosensitizer-modified catalase together with poly(ethylene glycol) double acrylate (PEGDA) as the polymeric matrix is designed. Read More

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http://dx.doi.org/10.1002/adma.201900927DOI Listing

Nurses' and nursing assistants' emotional skills: a major determinant of motivation for patient education.

J Adv Nurs 2019 Apr 22. Epub 2019 Apr 22.

Teaching Hospital of Lille, Transversal Unit of Patient Education, Lille, France.

Aims: To exploreprofessionals' (i.e. nurses and nursing assistants) motivation for Patient Educationaccording to their emotional skills. Read More

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http://dx.doi.org/10.1111/jan.14033DOI Listing

A simple empirical algorithm for optimizing depletion power and resolution for dye and system specific STED imaging.

J Microsc 2019 Apr 22. Epub 2019 Apr 22.

NHLBI Laboratory for Advanced Microscopy and Biophotonics, National Institutes of Health, Bethesda, Maryland, 20892-1061.

Here we show an easy method for determining an effective dye saturation factor ("P ") for STED (Stimulated Emission Depletion) microscopy. We define P to be a combined microscope system plus dye factor (analogous to the traditional ground truth I measurement, which is microscope independent) that is functionally defined as the power in the depletion beam that provides a resolution enhancement of 41% compared to confocal, according to the modified Abbe's formula for STED resolution enhancement. We show that the determination of P provides insight not only into the suitability of a particular dye and the best imaging parameters to be used for an experiment, but also sets the critical value for correctly determining the point spread function (PSF) used in deconvolution of STED images. Read More

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http://dx.doi.org/10.1111/jmi.12795DOI Listing

Grammatical gender processing in bilinguals: An analytic review.

Psychon Bull Rev 2019 Apr 22. Epub 2019 Apr 22.

Centro de Enseñanza Superior Cardenal Cisneros, Universidad Complutense de Madrid, Madrid, Spain.

In this review article, we analyze how grammatical gender is represented and processed in the bilingual mind. To that end, we review the data from 13 existing behavioral studies of mainly late second language (L2) learners on the so-called gender congruency (GC) effect (facilitated processing for translation equivalents with the same gender, in comparison to those with a different gender) in L2 production and comprehension. The majority of the results showed a GC effect, regardless of the type of language involved. Read More

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http://dx.doi.org/10.3758/s13423-019-01596-8DOI Listing

Association of vascular endothelial growth factor (VEGF) Gene polymorphisms and expression with the risk of endometriosis: a case-control study.

Mol Biol Rep 2019 Apr 22. Epub 2019 Apr 22.

Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, 5th Floor, Shariati Hospital Complex, North Kargar Ave, Tehran, 1411713135, Iran.

Endometriosis is a polygenic and multifactorial gynecology situation which might be associated with angiogenesis. In the current study we assess the role of vascular endothelial growth factor (VEGF) - 2578 A/C, and + 936 C/T polymorphisms in susceptibility to endometriosis and checking the expression of VEGF mRNA in eutopic tissue of endometrium with and without endometriosis. The study was comprised of 300 patients who underwent laparascopic or laparotomy surgery with 100 cases who had confirmed histological diagnosis of endometriosis, and 200 controls with no histological diagnosis of disease. Read More

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http://dx.doi.org/10.1007/s11033-019-04807-6DOI Listing

Conserved miRNAs modulate the expression of potential transcription factors of isoflavonoid biosynthetic pathway in soybean seeds.

Mol Biol Rep 2019 Apr 22. Epub 2019 Apr 22.

Division of Biochemistry, ICAR-Indian Agricultural Research Institute, Pusa Campus, New Delhi, 110 012, India.

Despite the significant importance of soybean isoflavone, the regulatory mechanism of miRNAs during its biosynthesis is highly unexplored. In the present work, nine existing miRNAs along with their ten corresponding target genes were identified and validated in soybean for their possible role during isoflavonoid biosynthesis and accumulation. Temporal expression analysis at four key stages of seed development (35, 45, 55 and 65DAF) of all the miRNA-target pairs showed varying degree of differential accumulation in two soybean genotypes (NRC37: high isoflavone; and NRC7: low isoflavone). Read More

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http://dx.doi.org/10.1007/s11033-019-04814-7DOI Listing

Sexual and Relationship Interest, Knowledge, and Experiences Among Adolescents and Young Adults with Autism Spectrum Disorder.

Arch Sex Behav 2019 Apr 22. Epub 2019 Apr 22.

Department of Special Education, College of Education, University of Missouri, Columbia, MO, USA.

Little research exists to describe sexual and romantic relationships among adolescents and young adults with autism spectrum disorder (ASD) from their perspectives. Sexuality and intimacy are developmentally important and influence health and quality of life for all adolescents and young adults, including those with ASD. This study explored and compared the sex and relationship experiences of 27 adolescents and young adults with ASD (males = 20). Read More

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http://dx.doi.org/10.1007/s10508-019-1445-2DOI Listing

Altered large-scale functional brain networks in neurological Wilson's disease.

Brain Imaging Behav 2019 Apr 22. Epub 2019 Apr 22.

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Wilson's disease patients with neurological symptoms have motor symptoms and cognitive deficits, including frontal executive, visuospatial processing, and memory impairments. Although the brain structural abnormalities associated with Wilson's disease have been documented, it remains largely unknown how Wilson's disease affects large-scale functional brain networks. In this study, we investigated functional brain networks in Wilson's disease. Read More

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http://dx.doi.org/10.1007/s11682-019-00066-yDOI Listing
April 2019
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Aging with multiple sclerosis: prevalence and profile of cognitive impairment.

Neurol Sci 2019 Apr 23. Epub 2019 Apr 23.

Department NEUROFARBA, Section Neurosciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.

Background: The increase in life expectancy of patients with multiple sclerosis (MS) requires a better knowledge of disease features in the older patients group.

Objective: To describe the prevalence and profile of cognitive impairment (CI) in older patients with MS and perform a comparison with younger patients.

Methods: Patients were consecutively recruited for 6 months. Read More

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http://dx.doi.org/10.1007/s10072-019-03875-7DOI Listing

An evaluation of mixed plant protein in the diet of Yellow River carp (Cyprinus carpio): growth, body composition, biochemical parameters, and growth hormone/insulin-like growth factor 1.

Fish Physiol Biochem 2019 Apr 23. Epub 2019 Apr 23.

Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Lab of Aquatic Animal Nutrition and Environmental Health, Shandong Agricultural University, 61 Daizong Street, Tai'an, 271018, Shandong Province, China.

The aim of this work is to evaluate the effects of dietary inclusion of mixed plant protein (MP) (rapeseed meal:cottonseed meal:peanut meal = 1:1:1) on growth, body composition, blood biochemical parameters, growth hormone/insulin-like growth factor 1, and relative non-specific immune response in Yellow River carp Cyprinus carpio. Five isonitrogenous and isoenergetic trial diets were formulated to replace fish meal at 0 (MP0, control), 25% (MP25), 50% (MP50), 75% (MP75), and 100% (MP100) mixed plant protein, respectively. The 25% mixed plant protein did not affect the weight gain, specific growth rate, and protein efficiency ratio, whereas these parameters were depressed by 50% and above mixed plant protein. Read More

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http://link.springer.com/10.1007/s10695-019-00641-6
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http://dx.doi.org/10.1007/s10695-019-00641-6DOI Listing

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.

Acta Neuropathol 2019 Apr 22. Epub 2019 Apr 22.

Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), 4 Soranou Efesiou Street, 11527, Athens, Greece.

Multiple system atrophy (MSA) is characterized by the presence of distinctive glial cytoplasmic inclusions (GCIs) within oligodendrocytes that contain the neuronal protein alpha-synuclein (aSyn) and the oligodendroglia-specific phosphoprotein TPPP/p25α. However, the role of oligodendroglial aSyn and p25α in the formation of aSyn-rich GCIs remains unclear. To address this conundrum, we have applied human aSyn (haSyn) pre-formed fibrils (PFFs) to rat wild-type (WT)-, haSyn-, or p25α-overexpressing oligodendroglial cells and to primary differentiated oligodendrocytes derived from WT, knockout (KO)-aSyn, and PLP-haSyn-transgenic mice. Read More

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http://dx.doi.org/10.1007/s00401-019-02014-yDOI Listing

A numerical coupling method for particle tracking in electromagnetic fields.

Eur Phys J E Soft Matter 2019 Apr 18;42(4):48. Epub 2019 Apr 18.

College of Electronics and Information Engineering, Sichuan University, 610065, Chengdu, China.

With the arrival of the information age, the electromagnetic energy in space increases constantly, resulting in the influence of electromagnetic waves on the charged aerosol particles in the environment which should be taken into account. Here, a numerical coupling method based on temporal and spatial scales is proposed to solve the difficulty in obtaining the trajectory of particles under the action of high-frequency electromagnetic waves. In the temporal scale, two constant forces with linear relationship are used to equilibrate the electromagnetic field forces under different conditions, however the above-mentioned equivalent method has the space limitation; in addition, on the spatial scale, the model with larger geometry should be divided into multiple basic modules spatially, the domain division method is adopted and due to the above method it can be used well in the basic module. Read More

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http://link.springer.com/10.1140/epje/i2019-11810-3
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http://dx.doi.org/10.1140/epje/i2019-11810-3DOI Listing

The Shigella type three secretion system effector OspF invades host nucleus by binding host importin α1.

World J Microbiol Biotechnol 2019 Apr 22;35(5):71. Epub 2019 Apr 22.

The State Key Laboratory Breeding Base of Bioresources and Eco-environments, Key Laboratory of Freshwater Fish Reproduction and Development, Laboratory of Molecular Developmental Biology, School of Life Sciences, Ministry of Education, Southwest University, Beibei, Chongqing, 400715, China.

Shigella type III effector OspF, a nuclear translocation protein, has been showed to have an essential role in Shigella flexneri infection and virulence; OspF increases inflammation and induces bacterial invasion by down-regulating MAPK kinases pathway. Nevertheless, the exact mechanisms underlying its nuclear translocation and signaling remain unclear. In the following study, we constructed series of OspF truncated mutants to identify the OspF nuclear localization signals which mapped to the amino acids 209-239. Read More

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http://dx.doi.org/10.1007/s11274-019-2635-8DOI Listing

Protein extract from head-foot tissue of Oncomelania hupensis promotes the growth and development of mother sporocysts of Schistosoma japonicum via upregulation of parasite aldolase gene.

Parasitol Res 2019 Apr 23. Epub 2019 Apr 23.

Department of Medical Parasitology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, Wuhan, 430071, Hubei, People's Republic of China.

Previous studies showed that protein extract from head-foot tissue of Oncomelania hupensis (O. hupensis) (PhfO), when cocultured with mother sporocysts of Schistosoma japonicum (S. japonicum), was beneficial for parasite's growth and development but the underlying mechanisms remain unclear. Read More

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http://link.springer.com/10.1007/s00436-019-06308-8
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http://dx.doi.org/10.1007/s00436-019-06308-8DOI Listing
April 2019
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Three BnaIAA7 homologs are involved in auxin/brassinosteroid-mediated plant morphogenesis in rapeseed (Brassica napus L.).

Plant Cell Rep 2019 Apr 22. Epub 2019 Apr 22.

Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture, Wuhan, 430062, China.

Key Message: BnaIAA7 crosstalk with BR signaling is mediated by the interaction between BnaARF8 and BnaBZR1 to regulate rapeseed plant morphogenesis. Auxin (indole-3-acetic acid, IAA) and brassinosteroids (BRs) are essential regulators of plant morphogenesis. However, their roles in rapeseed have not been reported. Read More

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http://dx.doi.org/10.1007/s00299-019-02410-4DOI Listing

Effects of long-term exercise on plasma adipokine levels and inflammation-related gene expression in subcutaneous adipose tissue in sedentary dysglycaemic, overweight men and sedentary normoglycaemic men of healthy weight.

Diabetologia 2019 Apr 22. Epub 2019 Apr 22.

Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway.

Aims/hypothesis: Obesity and insulin resistance may be associated with altered expression and secretion of adipokines. Physical activity can markedly improve insulin sensitivity, but the association with adipokines remains largely unknown. In this study, we examined the effects of physical activity on the subcutaneous white adipose tissue (scWAT) secretome and its relationship to insulin sensitivity. Read More

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http://dx.doi.org/10.1007/s00125-019-4866-5DOI Listing

Toxicity Test Assay of Waterborne Methylmercury on the Japanese Flounder (Paralichthys olivaceus) at Embryonic-Larval Stages.

Bull Environ Contam Toxicol 2019 Apr 22. Epub 2019 Apr 22.

CAS Key Laboratory of Marine Ecology and Environment Sciences, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China.

Methylmercury (MeHg) is a widespread pollutant in aquatic ecosystems, but its toxicity to the early life stages of marine fish has not been adequately investigated. This study used acute toxicity tests on embryonic-larval stages of a marine flounder Paralichthys olivaceus to determine the LC values for embryos and larvae and evaluate the responses of several biological endpoints to subacute MeHg exposure. Under exposures (0-15 μg L) below LC values ( < 15. Read More

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http://dx.doi.org/10.1007/s00128-019-02619-9DOI Listing

Regional Changes in Density and Microarchitecture in the Ultradistal Tibia of Female Recruits After U.S. Army Basic Combat Training.

Calcif Tissue Int 2019 Apr 22. Epub 2019 Apr 22.

Department of Defense Biotechnology High Performance Computing Software Applications Institute, Fort Detrick, MD, USA.

Musculoskeletal injuries, such as stress fracture, are responsible for over 10-million lost-duty days among U.S. Army Soldiers. Read More

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http://link.springer.com/10.1007/s00223-019-00548-7
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http://dx.doi.org/10.1007/s00223-019-00548-7DOI Listing
April 2019
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Pancreatic islet surface engineering with a starPEG-chondroitin sulfate nanocoating.

Biomater Sci 2019 Apr 23. Epub 2019 Apr 23.

Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China.

Islet transplantation is one of the most promising therapeutic options that could restore euglycaemia in type 1 diabetic individuals. The currently implemented alginate microsphere islet encapsulation approach has led to positive outcomes in improving intraportal islet delivery in rodents. However, results obtained from human clinical trials remain disappointing. Read More

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http://xlink.rsc.org/?DOI=C9BM00061E
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http://dx.doi.org/10.1039/c9bm00061eDOI Listing
April 2019
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A resorufin-based fluorescent probe for imaging polysulfides in living cells.

Analyst 2019 Apr 23. Epub 2019 Apr 23.

Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing, 10084, China.

As the oxidative metabolites of the endogenous gasotransmitter H2S, H2Sn have attracted ever-increasing attention in the field of biomedical research due to their vital functions in biological systems. Herein, we report a resorufin-based "turn-on" probe for H2Sn sensing. An SNAr substitution-intramolecular cyclization cascade reaction was used in this probe for detecting exogenous and endogenous H2Sn. Read More

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http://dx.doi.org/10.1039/c9an00377kDOI Listing

Applications of ENCODE data to Systematic Analyses via Data Integration.

Curr Opin Syst Biol 2018 Oct 29;11:57-64. Epub 2018 Aug 29.

Department of Biomedical Data Science, The Geisel School of Medicine at Dartmouth College, One Medical Center Dr., Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States, 03756.

Large-scale genomic data have been utilized to generate unprecedented biological findings and new hypotheses. To delineate functional elements in the human genome, the Encyclopedia of DNA Elements (ENCODE) project has generated an enormous amount of genomic data, yielding around 7,000 data profiles in different cell and tissue types. In this article, we reviewed the systematic analyses that have integrated ENCODE data with other data sources to reveal new biological insights, ranging from human genome annotation to the identification of new candidate drugs. Read More

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http://dx.doi.org/10.1016/j.coisb.2018.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474416PMC
October 2018

Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas.

Adv Radiat Oncol 2019 Apr-Jun;4(2):268-282. Epub 2018 Nov 20.

Department of Radiation Oncology, Centre François Baclesse, Esch-sur-Alzette, Luxembourg.

Purpose: Glioblastoma (GBM) remains an incurable disease despite extensive treatment with surgical resection, irradiation, and temozolomide. In line with many other forms of aggressive cancers, GBM is currently under consideration as a target for immunotherapy. However, GBM tends to be nonimmunogenic and exhibits a microenvironment with few or no effector T cells, a relatively low nonsynonymous somatic mutational load, and a low predicted neoantigen burden. Read More

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http://dx.doi.org/10.1016/j.adro.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460102PMC
November 2018

Polyethylene glycol (PEG) decorated graphene oxide nanosheets for controlled release curcumin delivery.

Heliyon 2019 Apr 10;5(4):e01466. Epub 2019 Apr 10.

Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.

Nowadays, the use of nanostructures in various medical and biological fields such as drug delivery in cancer treatment is increasing. Among the nanostructures, graphene oxide (GO) is an excellent candidate for drug delivery application because of its unique properties. For more stability, GO can bind with various polymers by its carboxyl, hydroxyl and epoxy functional groups. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460424PMC

Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB).

Biomed Res Int 2019 18;2019:3235021. Epub 2019 Mar 18.

Department of Breast and Thyroid Surgery, Zhongnan Hospital, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan University, Wuhan 430071, Hubei, China.

Background: Breast cancer (BC) is one of the most common malignant tumors in women around the world. Atorvastatin (ATO) was found to be associated with a decreased risk of recurrence and mortality in cancer. But the exact mechanism of its carcinostatic effects is unclear. Read More

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http://dx.doi.org/10.1155/2019/3235021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442491PMC