297,763 results match your criteria Basal Cell Carcinoma Eyelid
Biomed Pharmacother 2018 Dec 3;110:285-293. Epub 2018 Dec 3.
Department of Organ Transplantation, ChangZheng Hospital, Second Military Medical University, Shanghai, 200003, China. Electronic address:
Objective: Wuzhi (WZ) capsule contains an ethanol extract of Schisandra sphenanthera. The efficacy of WZ in treating non-alcoholic fatty liver disease (NAFLD) has not yet been elucidated. The present study assessed the effects of WZ on NAFLD. Read More
Behav Brain Res 2018 Dec 3. Epub 2018 Dec 3.
Program in Neuroscience, University of Arizona, Gould-Simpson Building, Tucson, AZ, 85721, United States; Department of Neuroscience, University of Arizona, Gould-Simpson Building, Tucson, AZ. 85721, United States; Department of Speech, Language, and Hearing Sciences, University of Arizona, Speech, Language, and Hearing Sciences Building, Tucson, AZ, 85721, United States. Electronic address:
Dopamine (DA) is an important neuromodulator of motor control across species. In zebra finches, DA levels vary in song nucleus Area X depending upon social context. DA levels are high and song output is less variable when a male finch sings to a female (female directed, FD) compared to when he is singing by himself (undirected, UD). Read More
Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.
Beijing Advanced Innovation Centre for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing 100083, China; Institute of Microbiology, Beijing Forestry University, Beijing 100083, China.
To contribute towards effective exploitation and utilization of natural antioxidants, response surface methodology (RSM) was employed to optimize the medium composition for the production of exopolysaccharides from the medicinal mushroom Ganoderma lingzhi (GLEPS). An optimal medium for GLEPS production was gave through Plackett-Burman design, path of steepest ascent, and Box-Behnken design as follows: glucose (59.62 g/L), yeast extract (10. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013186. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Edgbaston Campus, Birmingham, UK, B15 2TT.
Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high-risk skin cancers which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013189. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Edgbaston Campus, Birmingham, UK, B15 2TT.
Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers, which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised, with potential to infiltrate and damage surrounding tissue. Anxiety around missing early cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013187. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Edgbaston Campus, Birmingham, UK, B15 2TT.
Background: Early accurate detection of all skin cancer types is essential to guide appropriate management, reduce morbidity and improve survival. Basal cell carcinoma (BCC) is usually localised to the skin but has potential to infiltrate and damage surrounding tissue, while cutaneous squamous cell carcinoma (cSCC) and melanoma have a much higher potential to metastasise and ultimately lead to death. Exfoliative cytology is a non-invasive test that uses the Tzanck smear technique to identify disease by examining the structure of cells obtained from scraped samples. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD011901. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Early accurate detection of all skin cancer types is important to guide appropriate management, to reduce morbidity and to improve survival. Basal cell carcinoma (BCC) is almost always a localised skin cancer with potential to infiltrate and damage surrounding tissue, whereas a minority of cutaneous squamous cell carcinomas (cSCCs) and invasive melanomas are higher-risk skin cancers with the potential to metastasise and cause death. Dermoscopy has become an important tool to assist specialist clinicians in the diagnosis of melanoma, and is increasingly used in primary-care settings. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013191. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Early accurate detection of all skin cancer types is important to guide appropriate management and improve morbidity and survival. Basal cell carcinoma (BCC) is usually a localised skin cancer but with potential to infiltrate and damage surrounding tissue, whereas cutaneous squamous cell carcinoma (cSCC) and melanoma are higher risk skin cancers with the potential to metastasise and ultimately lead to death. When used in conjunction with clinical or dermoscopic suspicion of malignancy, or both, reflectance confocal microscopy (RCM) may help to identify cancers eligible for non-surgical treatment without the need for a diagnostic biopsy, particularly in people with suspected BCC. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013193. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013188. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Early, accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers with the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised, with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More
PLoS One 2018 6;13(12):e0208620. Epub 2018 Dec 6.
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Background: Anterior temporal lobe hyperintensities detected by brain MRI are a recognized imaging hallmark of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Because similar findings may be present in patients with myotonic dystrophy type 1 (DM1), the brain MRI in these two diseases is often misinterpreted. We compared the MRI findings between the two entities to examine whether they display distinctive characteristics. Read More
FASEB J 2018 Dec 6:fj201800981R. Epub 2018 Dec 6.
Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
As mechanisms controlling redox homeostasis become impaired with aging, exaggerated oxidant stress may cause disproportional oxidation of cell membranes and circulating phospholipids (PLs), leading to the formation of truncated oxidized PL products (Tr-OxPLs), which exhibit deleterious effects. This study investigated the role of elevated Tr-OxPLs as a factor exacerbating inflammation and lung barrier dysfunction in an animal model of aging. Mass spectrometry analysis of Tr-OxPL species in young (2-4 mo) and aging (18-24 mo) mice revealed elevated basal levels of several products [1-palmitoyl-2-(5-oxovaleroyl)- sn-glycero-phosphocholine (POVPC), 1-palmitoyl-2-glutaroyl- sn-glycero-phosphocholine, lysophosphocholine, 1-palmitoyl-2-(9-oxo-nonanoyl)- sn-glycero-3-phosphocholine, 1-palmitoyl-2-azelaoyl- sn-glycero-3-phosphocholine, O-1-O-palmitoyl-2-O-(5,8-dioxo-8-hydroxy-6-octenoyl)-l-glycero-3-phosphocholine, and others] in the aged lungs. Read More
Dermatol Ther 2018 Dec 6:e12799. Epub 2018 Dec 6.
Department of Dermatology, San Jacopo Hospital, V. Ciliegiole 1, 51100 Pistoia, Italy.
J Biochem 2018 Dec 5. Epub 2018 Dec 5.
Department of Biosciences, College of Humanities and Sciences, Nihon University, 3-25-40 Sakurajosui, Setagaya-ku, Tokyo, Japan.
The amino acid sequence of the motor domain of AnKinA, kinesin-1 from Aspergillus nidulans, growing optimally at 37°C, was compared with that of SbKin1, kinesin-1 from the snow mold Sclerotinia borealis. For cold-adaptation, some enzymes are thought to exhibit augmented protein structure flexibility, acquired most effectively by substituting a glycine residue for another amino acid residue. By the comparison described above, two glycine residues proximal to tightly-bound ADP were identified in the SbKin1 motor domain, of which the corresponding residues of AnKinA were non-glycine ones (P60 and S323). Read More
Appl Immunohistochem Mol Morphol 2018 Dec 4. Epub 2018 Dec 4.
Department of Clinical Specialistic and Dental Sciences.
The present study investigated the immunohistochemical expression of p53, p63, and p73 in different types of odontogenic cysts (OC), a group of common intraosseous jaw lesions, to provide a better understanding of p53-family functions in odontogenic lesions. We carried out immunohistochemical analysis to evaluate the expression of p53, p63, and p73 in 60 samples of OC, including dentigerous cysts, radicular cysts, orthokeratinized OC, and odontogenic keratocysts (OKC). The epithelial expression of p53-family members was evaluated both in the basal-parabasal and in the superficial layers, measuring the percentage of positive cells and the value of expression intensity. Read More
Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.
Department of Clinical Physiology and Nuclear Medicine, Hvidovre University Hospital.
Dietary fat, and particularly fatty acids from hydrolyzed triglycerides, reduce appetite, whereas, paradoxically, a high-fat diet leads to excess calorie intake and weight gain. We therefore hypothesized that the appetite-regulating effects of dietary fat is perturbed in obesity. Ten men with severe obesity (median BMI 51. Read More
J Diabetes Investig 2018 Dec 6. Epub 2018 Dec 6.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Diabetes remains a global epidemic problem and a tremendous health challenge especially in Asian population. Dramatic increases in the prevalence of diabetes across different countries or areas in Asia have been reported in recent epidemiological studies. While clinical guidelines have strengthen appropriate anti-hyperglycaemic medications and lifestyle modifications for optimal diabetes management, inadequate glycaemic control still occurs in many patients with an increased risk of developing microvascular and macrovascular complications. Read More
Curr Neuropharmacol 2018 Dec 5. Epub 2018 Dec 5.
Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO. United States.
The co-agonist concerted transition model is a simple and practical solution to analyzing various aspects of GABAA receptor function. Several model-based predictions have been verified experimentally in previous reports. We review here the practical implications of the model and demonstrate how it enables simplification of the experimental procedure and data analysis to characterize the effects of mutations or properties of novel ligands. Read More
Biotechnol J 2018 Dec 6:e1800380. Epub 2018 Dec 6.
College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China.
Marine microalgae has great potential for lutein production with the advantage of saving fresh water resource. Thus, marine microalga Chlamydomonas sp. JSC4 was investigated as a potential lutein producer in this study. Read More
Diabetes Obes Metab 2018 Dec 6. Epub 2018 Dec 6.
University of Perugia School of Medicine, Perugia, Italy.
Aims: To identify factors associated with achievement of glycated haemoglobin A1c (HbA1c) target at 24 weeks after commencing basal insulin therapy in people with type 2 diabetes mellitus (T2DM).
Materials And Methods: Post-hoc pooled analysis of 16 randomised, treat-to-target trials involving people with T2DM inadequately controlled on oral anti-hyperglycaemic drugs (n=3415) initiated on once-daily insulin glargine 100 U/mL (Gla-100). Clinical outcomes were assessed by HbA1c response at 24 weeks and people classified as "good responders" by reaching HbA1c <7. Read More
J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.
Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Background: several observational studies have suggested differences in the risk factor profile between patients with superficial basal cell carcinomas (BCCs) and non-superficial BCCs.
Objective: to test the reproducibility of previous study findings and to find new genetic and non-genetic predictors for patients with a superficial first BCC.
Methods: 14. Read More
J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.
Dermatology Clinic - Department of Medical Science and Public Health, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy.
Background: The clinical and dermoscopic changes of melanocytic nevi under the effects of photo-epilation are poorly known.
Objective: Prospective study on clinical and dermatoscopic effects of photoepilation on melanocytic nevi.
Methods: Eighteen patients exposed to photo-epilation gave consent to a follow-up program from 2008 to 2017 at the Videodermatoscopic Office of the Dermatology Clinic of Cagliari (Italy), with clinical and dermoscopic assessment. Read More
J Vet Intern Med 2018 Dec 5. Epub 2018 Dec 5.
Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, Victoria, Australia.
Background: The importance of including exercise with dietary modification for the management of obese equids is not clearly understood.
Objectives: To evaluate the effect of a practical low-intensity exercise regimen, in addition to dietary restriction, on indices of insulin sensitivity (SI) and plasma adipokine concentrations in obese equids.
Animals: Twenty-four obese (body condition score [BCS] ≥ 7/9) horses and ponies. Read More
Hepatology 2018 Dec 5. Epub 2018 Dec 5.
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Autophagy is important for hepatic homeostasis, nutrient regeneration and organelle quality control. We investigated the mechanisms by which liver injury occurred in the absence of autophagy function. We found that mice deficient in autophagy due to the lack of Atg7 or Atg5, key autophagy-related genes, manifested intracellular cholestasis with increased levels of serum bile acids, a higher ratio of TMCA/TCA in the bile, increased hepatic bile acid load, abnormal bile canaliculi and altered expression of hepatic transporters. Read More
J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.
Department of Environmental Science and Policy, Università degli Studi di Milano, Milano, Italy.
Neural development of echinoderms has always been difficult to interpret, as larval neurons degenerate at metamorphosis and a tripartite nervous system differentiates in the adult. Despite their key phylogenetic position as basal echinoderms, crinoids have been scarcely studied in developmental research. However, since they are the only extant echinoderms retaining the ancestral body plan of the group, crinoids are extremely valuable models to clarify neural evolution in deuterostomes. Read More
J Neurochem 2018 Dec 6. Epub 2018 Dec 6.
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
HIV-associated neurocognitive disorder (HAND) affects about half of HIV-infected patients. HIV impairs neuronal function through indirect mechanisms mainly mediated by inflammatory cytokines and neurotoxic viral proteins, such as the envelope protein gp120. HIV gp120 elicits a neuroinflammatory response that potentiates NMDA receptor function and induces the loss of excitatory synapses. Read More
Br J Dermatol 2018 Dec 5. Epub 2018 Dec 5.
Department of Dermatology, Maastricht University Medical Center, Maastricht, the Netherlands.
Basal cell naevus syndrome (BCNS) is associated with germline mutations in the PTCH1 gene. Postzygotic mosaicism can also cause BCNS. Here we describe two patients, one with multiple basal cell carcinomas (BCCs) and one with clinical BCNS, who had no PTCH1 mutation in DNA extracted from blood. Read More
Methods Mol Biol 2019 ;1888:233-254
Chemical Biology and Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
We recently pioneered several analyses of small-molecule sensitivity data collected from large-scale perturbation of hundreds of cancer cell lines with hundreds of small molecules, with cell viability measured as a readout of compound sensitivity. We performed these studies using cancer cell lines previously annotated with cellular, genomic, and basal gene-expression features. By combining small-molecule sensitivity data with these other datasets, we identified new candidate biomarkers of sensitivity, gained insights into small-molecule mechanisms of action, and proposed candidate hypotheses for cancer dependencies (including candidate combination therapies). Read More
Ophthalmol Ther 2018 Dec 5. Epub 2018 Dec 5.
Manchester Royal Eye Hospital, Manchester Academic Health Science Centre, Manchester, UK.
Introduction: Infantile nephropathic cystinosis (INC) is an autosomal recessive lysosomal disorder in which patients develop deposits of cystine crystals in their kidneys and corneas from a young age.
Methods: We conducted a retrospective analysis of children with INC seen by ophthalmologists at the Manchester Royal Eye Hospital between 2002 and 2018, to evaluate clinical findings, symptoms and treatment.
Results: Twenty-two children diagnosed with INC from age 0 (prenatally) to 11 years were assessed. Read More
Rice (N Y) 2018 Dec 5;11(1):63. Epub 2018 Dec 5.
Graduate School of Life Sciences, Tohoku University, Sendai, 980-8577, Japan.
Background: The rice blast resistance gene Pi54 was cloned from Oryza sativa ssp. indica cv. Tetep, which conferred broad-spectrum resistance against Magnaporthe oryzae. Read More
Mol Neurobiol 2018 Dec 6. Epub 2018 Dec 6.
Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA.
The canonical Wnt pathway is critical for both the development and adulthood survival and homeostatic maintenance of the midbrain dopaminergic (DA) neurons. Expanding evidence has demonstrated that genetic factors associated with familial Parkinson disease (PD) deregulate this important pathway, suggesting that a disturbed canonical Wnt pathway is likely involved in PD pathogenesis; yet, the specific role of this pathway in sporadic PD remains unclear. In this study, we aimed to determine the effects of specific inhibition of the canonical pathway by hemizygous knockout of β-catenin, the obligatory component of the canonical Wnt pathway, on paraquat (PQ)-induced DA neuronal degeneration in the substantia nigra in vivo. Read More
PeerJ 2018 29;6:e5945. Epub 2018 Nov 29.
Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, VIC, Australia.
Background: In horses and ponies, insulin dysregulation leading to hyperinsulinemia may be associated with increased risk of laminitis, and prolonged infusion of insulin can induce the condition. It is unclear whether insulin may have a direct or indirect effect on the lamellar tissues. Insulin is structurally related to insulin-like growth factor (IGF-1), and can bind the IGF-1 receptor, albeit at a lower affinity than IGF-1. Read More
Ecol Evol 2018 Nov 18;8(22):11199-11212. Epub 2018 Oct 18.
Graduate School of Science and Technology Shinshu University Matsumoto Japan.
Tree species of three growth forms (evergreen conifers, deciduous hardwoods, and evergreen hardwoods) codominate at the northern distribution limit of evergreen hardwoods in central Japan. This study examined the stand dynamics and competition during 13 years at a single plot to reveal how three growth forms codominate at the ecotone. Species were characterized as large DBH and low tree density for evergreen conifers, and conversely for evergreen hardwoods. Read More
Evid Based Complement Alternat Med 2018 1;2018:9194362. Epub 2018 Nov 1.
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Radix Astragali (RA) herb with warm property and significant "tonifying qi" effects is indicated for the syndrome of internal cold due to Yang deficiency. The purpose of this research was to explore effects of Radix Astragali (RA) through PPAR signaling pathway on gene expression profiles related to energy metabolism in rats with the Yang-deficiency cold (YDC) syndrome, for identifying the pathological mechanism of Yang-deficiency cold (YDC) syndrome and the effects mechanism of RA. The results indicated that RA could significantly increase body weight (BM), cold and heat tendency (CT), overall temperature (OT), rectum temperature (RT), toe temperature (TT), energy intake (EI), and V(O)/V(CO) ratio (which indicates basal metabolism, BM) (P<0. Read More
Front Psychol 2018 21;9:2240. Epub 2018 Nov 21.
Psychiatric Services Solothurn, Solothurn, Switzerland.
Learning is the relatively permanent change of behavior as a result of experience and tightly related to memory and cognition. Learning is particularly important for children. Further, restoring sleep is associated both with improved learning performance and lower cortisol levels as a proxy of the so-called hypothalamus-pituitary-adrenocortical axis activity (HPA-AA). Read More
Front Physiol 2018 21;9:1406. Epub 2018 Nov 21.
Department of Biology, University of Waterloo, Waterloo, ON, Canada.
The appearance of voltage-gated, sodium-selective channels with rapid gating kinetics was a limiting factor in the evolution of nervous systems. Two rounds of domain duplications generated a common 24 transmembrane segment (4 × 6 TM) template that is shared amongst voltage-gated sodium (Na1 and Na2) and calcium channels (Ca1, Ca2, and Ca3) and leak channel (NALCN) plus homologs from yeast, different single-cell protists (heterokont and unikont) and algae (green and brown). A shared architecture in 4 × 6 TM channels include an asymmetrical arrangement of extended extracellular L5/L6 turrets containing a 4-0-2-2 pattern of cysteines, glycosylated residues, a universally short III-IV cytoplasmic linker and often a recognizable, C-terminal PDZ binding motif. Read More
Front Cell Neurosci 2018 21;12:442. Epub 2018 Nov 21.
Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.
Regulation of exo- and endocytosis of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor (AMPAR) plays a critical role in the expression of synaptic plasticity such as long-term potentiation (LTP) and long-term depression (LTD) at excitatory central synapses. Enhanced AMPAR exocytosis or endocytosis has been suggested to contribute to LTP or LTD, respectively. However, several unsettled fundamental questions have remained about AMPAR exo- and endocytosis in the basal condition and during synaptic plasticity: (1) Does the size of each exo- or endocytosis event, and/or do the frequencies of these events change during LTP or LTD? If they change, what are the time courses of the respective changes? (2) Where does the exo- or endocytosis preferentially occur in each condition: inside or in the vicinity of postsynaptic membrane, or in the extrasynaptic membrane? (3) Do different types of AMPAR, such as GluA1 homo-tetramer, GluA1/2 hetero-tetramer and GluA2/3 hetero-tetramer, show distinct exo- and endocytosis changes? To address these questions, we developed new methods to observe individual events of AMPAR exo- or endocytosis with a high signal to noise (SN) ratio in a culture preparation using total internal reflection fluorescence microscopy (TIRFM). Read More
Hypertens Res 2018 Dec 5. Epub 2018 Dec 5.
Department. of Experimental Hypertension, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
Basal calcium sensitization is decreased in spontaneously hypertensive rats, although their blood pressure (BP) response to acute Rho-kinase inhibition is enhanced. Using fasudil (Rho-kinase inhibitor) or nifedipine (L-VDCC blocker), we evaluated the contribution of calcium sensitization and calcium entry to BP maintenance in hypertensive transgenic Ren-2 rats (TGR) focusing on the influence of major vasoactive systems and/or baroreflex efficiency on BP responses to these two drugs. Homozygous TGR and normotensive Hannover Sprague-Dawley (HanSD) control rats aged 5, 11, or 22 weeks were used. Read More
Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.
Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh, EH3 9HA, NHS Lothian, UK.
Pediatr Res 2018 Dec 5. Epub 2018 Dec 5.
Keck School of Medicine of University of Southern California, Division of Neonatology, Department of Pediatrics, LAC+USC Medical Center, Los Angeles, CA, USA.
Neonatal hyperbilirubinemia is one of the most frequent diagnoses made in neonates. A high level of unconjugated bilirubin that is unbound to albumin is neurotoxic when the level exceeds age-specific thresholds or at lower levels in neonates with neurotoxic risk factors. Lower range of unbound bilirubin results in apoptosis, while moderate-to-high levels result in neuronal necrosis. Read More
Nat Plants 2018 Dec 3;4(12):1082-1088. Epub 2018 Dec 3.
IST Austria, Klosterneuburg, Austria.
Cell polarity, manifested by the localization of proteins to distinct polar plasma membrane domains, is a key prerequisite of multicellular life. In plants, PIN auxin transporters are prominent polarity markers crucial for a plethora of developmental processes. Cell polarity mechanisms in plants are distinct from other eukaryotes and still largely elusive. Read More
Sci Rep 2018 Dec 5;8(1):17651. Epub 2018 Dec 5.
Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway.
Phospho flow is a powerful approach to detect cell signaling aberrations, identify biomarkers and assess pharmacodynamics, and can be performed using cryopreserved samples. The effects of cryopreservation on signaling responses and the reproducibility of phospho flow measurements are however unknown in many cell systems. Here, B lymphocytes were isolated from healthy donors and patients with the B cell malignancy chronic lymphocytic leukemia and analyzed by phospho flow using phospho-specific antibodies targeting 20 different protein epitopes. Read More
J Vet Med Sci 2018 Dec 6. Epub 2018 Dec 6.
Department of Pathogenetic Veterinary Science, United Graduate School of Veterinary Science, Gifu University.
Here, we investigated the effects of 9-hydroxyphenanthrene (9-phenanthrol), a potent and selective transient receptor potential melastatin 4 (TRPM4) channel blocker, on the resting membrane potential and cholinergic contractile responses to elucidate the functional role of TRPM4 channels in the contractile activities of mouse detrusor and ileal longitudinal smooth muscles. We observed that, 9-phenanthrol (3-30 µM) did not significantly inhibit high K-induced contractions in both preparations; however, 9-phenanthrol (10 µM) strongly inhibited cholinergic contractions evoked by electrical field stimulation in detrusor preparations compared to inhibitions in ileal preparations. 9-Phenanthrol (10 µM) significantly inhibited the muscarinic agonist, carbachol-induced contractile responses and slowed the maximum upstroke velocities of the contraction in detrusor preparations. Read More
J Cell Sci 2018 Dec 5. Epub 2018 Dec 5.
Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA
Loss of () is associated with loss of primary cilia and is causally linked to elevated Aurora Kinase A (AURKA). We developed an image-based HTS assay using a dual-labelling image analysis strategy that identifies both the cilium and the basal body. Using this strategy, we screened small molecule compounds for the targeted rescue of cilia defects associated with -deficiency with high accuracy and reproducibility. Read More
J Neurosci 2018 Dec 5. Epub 2018 Dec 5.
Cellular Neuroscience, Neurodegeneration & Repair, Departments of Neurology and of Neuroscience, Yale University School of Medicine, New Haven, CT USA 06536.
Dozens of genes have been implicated in Late Onset Alzheimer's Disease (AD) risk, but none have a defined mechanism of action in neurons. Here, we show that the risk factor Pyk2 (PTK2B) localizes specifically to neurons in adult brain. Absence of Pyk2 has no major effect on synapse formation nor the basal parameters of synaptic transmission in the hippocampal Schaffer collateral pathway. Read More
Ugeskr Laeger 2018 Nov;180(48)
Non-melanoma skin cancers are the most common malignant neoplasms in Denmark. The majority of cases are basal cell carcinomas (BCC) and squamous cell carcinomas (SCC). The choice of treatment depends on tumour, area, histology and patient-specific factors. Read More
Langmuir 2018 Dec 5. Epub 2018 Dec 5.
Cellular adhesion is a central element in tissue mechanics, biological cell-cell signaling, and cell motility. In this context, the cell-substrate distance has been investigated in the past by studying natural cells and biomimetic cell models adhering on solid substrates. The amount of water in the membrane substrate gap, however, is difficult to determine. Read More
Molecules 2018 Dec 4;23(12). Epub 2018 Dec 4.
Department of Chemistry, University of Nairobi, P. O. Box 30197, 00100 Nairobi, Kenya.
A phytochemical investigation of the roots of led to the isolation of -kaurane-type diterpenoids and additional phytochemicals (⁻). The structures of the isolated compounds were elucidated based on Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analyses. The absolute configurations of seven of the -kaurane-type diterpenoids (⁻, and ) were determined by single crystal X-ray diffraction studies. Read More
Nutrition 2018 Aug 23;60:1-5. Epub 2018 Aug 23.
Center of Investigation of Endocrinology and Nutrition, Medical School, Department of Endocrinology and Investigation, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Objectives: The role of ADIPOQ gene variants on weight loss after a dietary intervention remain unclear. The aim of this study was to analyze the effects of rs266729 of the ADIPOQ gene on cardiovascular risk factors and adiposity parameters after adherence to a Mediterranean-type hypocaloric diet.
Method: Eighty-three obese patients were studied before and after 12 wk on a Mediterranean-type hypocaloric diet. Read More
Protein Expr Purif 2018 Nov 30. Epub 2018 Nov 30.
College of Life Science and Biotechnology, Shihezi University, Shihezi, 832000, China. Electronic address:
To optimize the expression conditions for human lactoferrin production, we have constructed the transgenic chlorella with human lactoferrin named as GTD8A1-HLF, the original chlorella was separated from Gurbantunggut Desert in Xinjiang China. To further improve the production of human lactoferrin, a sequential methodology was used to optimize human lactoferrin production by GTD8A1-HLF. First, a screening trial using a Plackett-Burman design was done, and variables with statistically significant effects on human lactoferrin bio-production were identified. Read More