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Am J Dermatopathol 2021 Jun 2. Epub 2021 Jun 2.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Abstract: Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare low-grade adnexal malignancy with a predilection for the eyelids of elderly White women, which is associated with invasive mucinous carcinoma with endocrine features in one-third of cases. EMPSGC is characterized by the presence of neuroendocrine differentiation and mucin production. However, EMPSGC displays a variety of architectural patterns including solid, cribriform, papillary, and cystic growth. Read More

Cureus 2021 Apr 15;13(4):e14509. Epub 2021 Apr 15.

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

The purpose of this case report is to demonstrate the outcomes of reconstruction in small-to-moderate-sized benign tumors of eyelids by using the propeller flap technique. Propeller flaps have been used by plastic surgeons for facial reconstruction and other body parts. However, very few oculoplastic surgeons have utilized this technique in eyelid reconstructive surgeries. Read More

Dermatol Ther 2021 May 27:e15006. Epub 2021 May 27.

Division of Melanoma Surgery, Sarcoma and Rare Tumors, IRCCS, Istituto Europeo di Oncologia, Milan, Italy.

Basal cell carcinoma (BCC) can sometimes affect the eyelids and in particular the eyelid margin, where it can often be misdiagnosed, mimicking other benign, more common diseases. Dermoscopy may provide additional diagnostic criteria for an earlier diagnosis of eyelid margin BCC, although the dermoscopic features of BCC affecting this anatomical site have seldom been reported. We highlight the peculiar presence of linear vessels perpendicular to the eyelid margin in BCCs of the eyelid margin. Read More

Ophthalmologe 2021 May 27. Epub 2021 May 27.

Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.

Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3S):S119-S120

Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3S):S116-S117

Indian J Ophthalmol 2021 06;69(6):1368

Advanced Eye Centre, Department of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Biomed Opt Express 2021 Apr 11;12(4):2015-2026. Epub 2021 Mar 11.

School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom.

We present the first clinical integration of a prototype device based on integrated auto-fluorescence imaging and Raman spectroscopy (Fast Raman device) for intra-operative assessment of surgical margins during Mohs micrographic surgery of basal cell carcinoma (BCC). Fresh skin specimens from 112 patients were used to optimise the tissue pre-processing and the Fast Raman algorithms to enable an analysis of complete Mohs layers within 30 minutes. The optimisation allowed >95% of the resection surface area to be investigated (including the deep and epidermal margins). Read More

Ocul Oncol Pathol 2021 Mar 2;7(2):149-158. Epub 2020 Dec 2.

The MUHC, McGill University Ocular Pathology and Translational Research Laboratory, McGill University, Montreal, Québec, Canada.

Introduction: Optical coherence tomography (OCT) imaging has been used as a diagnostic tool for retinal disease for several years, and OCT apparatuses are becoming increasingly powerful. However, OCT has yet to reach its full potential in ophthalmology clinics. Alike retinal layers, it has been shown that OCT is able to generate cross-sectional images of the skin and allows visualization of skin lesions in a histopathology-like manner. Read More

Orbit 2020 Dec 1:1-6. Epub 2020 Dec 1.

Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, USA.

: Lid-sharing approaches are often advocated for repair of large full thickness lower eyelid defects, however result in temporary visual obstruction and the need for a second-stage procedure. The authors describe and report outcomes using a one-stage technique utilizing a free tarsoconjunctival graft (TCG) and musculocutaneous transposition flap (MCT) to repair defects up to 90% of the lower eyelid.: A retrospective chart review on patients that had undergone full thickness lower eyelid reconstruction using a TCG and MCT between the dates of 1/1/2015 to 3/1/2020 was performed. Read More

JPRAS Open 2021 Jun 24;28:131-139. Epub 2021 Mar 24.

Department of Plastic Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan.

Background: Numerous reports have described methods for repairing full-thickness upper eyelid defects using lower eyelid tissue. To avoid sacrificing the lower eyelid and thereby prevent lower eyelid sagging or dysfunction, we used innervated orbicularis oculi myocutaneous flaps harvested from the upper eyelid for upper eyelid reconstruction.

Methods: We modified a method reported by Moschella and Cordova for repairing full-thickness upper eyelid defects using innervated bipedicled orbicularis oculi myocutaneous flaps mobilized from the upper eyelid and labial mucosal grafts. Read More

J Glaucoma 2021 Feb;30(2):206-208

Ophthalmic Plastic and Reconstructive Surgery Division, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, NY.

An 81-year-old man with primary open-angle glaucoma on dorzolamide-timolol, bimatoprost and 0.02% netarsudil ophthalmic solution (Rhopressa), was found to have right lower lid basal cell carcinoma. The patient underwent Mohs surgery followed by repair of the right lower lid, with 3 episodes of wound dehiscence. Read More

J Craniofac Surg 2021 Mar 25. Epub 2021 Mar 25.

Department of Ophthalmology and Visual Sciences, Division of Ophthalmic Plastic and Reconstructive Surgery, Paulista School of Medicine - EPM, Federal University of S. Paulo - UNIFESP, Sao Paulo, Brazil.

Abstract: Eyelid malignancies are frequently seen in clinical practice. There is a lack of studies that have assessed the features of these lesions in mixed population countries. The epidemiologic profile, clinical stage at presentation, management, and outcomes of patients with eyelid malignancies were assessed, in order to better understand the features of these lesions in a multi-ethnic country. Read More

J Microsc Ultrastruct 2021 Jan-Mar;9(1):12-17. Epub 2020 Nov 9.

Department of Pathology, North Bengal Medical College and Hospital, Siliguri, West Bengal, India.

Context: Eyelids by virtue of its unique histomorphology give rise to multitudes of different pathological conditions. Appropriate preoperative cytological diagnoses of these cases are necessary to determine their optimal therapy.

Aims: The aims of this study were to evaluate the utility of various cytological techniques in diagnosing the definite pathology for palpebral lesions and thereby to highlight the drawbacks associated with cytology in this context. Read More

Acta Dermatovenerol Croat 2020 Dec;28(7):233-235

Martyna Sławińska MD, PhD, Department of Dermatology, Venereology and Allergology Medical University of Gdańsk, Smoluchowskiego 17 Street, 80-214 Gdańsk;

Giant molluscum contagiosum (MC) is a peculiar variant of the disease with the presence of multiple or single lesions larger than 5 mm. In contrast to typical molluscum contagiosum, dermoscopic features of giant lesions have been poorly described, and none of the reports included multiple giant lesions in an immunocompromised patient. We present a patient with acquired immunodeficiency syndrome diagnosed with multiple giant molluscum contagiosum along with the dermoscopic features of this entity. Read More

World J Plast Surg 2021 Jan;10(1):125-131

Beverly Hills Sunset Surgery Center at Valiant Clinic Dubai, United Arab Emirates.

A 65-year-old female patient with a histologically confirmed basal cell carcinoma located at the right lateral lower eyelid was referred for surgical tumour excision and reconstruction of the periorbital area. The periocular zone was reconstructed in a two-staged procedure with bilamellar repair of both eyelids. An autologous chondral graft, mucosal advancement techniques and a periosteum-temporalis fascia hinged turnover flap were used for reconstruction of the posterior lamellae. Read More

Cancers (Basel) 2021 Mar 20;13(6). Epub 2021 Mar 20.

Department of Radiotherapy, Medical University of Lublin, 20-093 Lublin, Poland.

Background: Eyelid tumors are rare skin cancers, the most common of which is basal cell carcinoma characterized primarily by local growth. In addition to surgery, radiotherapy is among the basic methods of treatment. External beam radiotherapy is associated with the risk of complications within ocular structures, especially the lens. Read More

Can J Ophthalmol 2021 Mar 11. Epub 2021 Mar 11.

Institut Curie, Service d'oncologie oculaire, Paris, France.

Objective: To evaluate the outcomes of orbital exenteration with temporalis muscle flap repair of the socket and secondary healing of the anterior surface of the flap in ocular, conjunctival, and eyelid malignancies.

Design: Retrospective single-centre study.

Participants: Consecutive patients who underwent total exenteration for malignancy with temporal muscle flap repair of the socket between December 2009 and January 2016. Read More

Clin Ophthalmol 2021 26;15:871-879. Epub 2021 Feb 26.

Apollo Specialty Hospital, Navi Mumbai, India.

Purpose: To study the level of serum malondialdehyde (MDA), a biomarker of oxidative stress before and after chemotherapy in various ocular malignancies and to correlate its significance with clinicopathological parameters.

Methods: Thirty two histopathologically confirmed cases of primary ocular malignancies were included in this longitudinal cohort study. Detailed clinicopathological assessment was done. Read More

J Am Acad Dermatol 2021 Jun 27;84(6):e303. Epub 2021 Feb 27.

Department of Dermatology, University Hospital of Siena, Siena, Italy.

J Am Acad Dermatol 2021 Jun 25;84(6):e305. Epub 2021 Feb 25.

Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida; Sylvester Comprehensive Cancer Center, Miami, Florida. Electronic address:

Postepy Dermatol Alergol 2020 Dec 6;37(6):927-931. Epub 2021 Jan 6.

Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, The University Hospital, Krakow, Poland.

Introduction: The aim of periocular basal cell carcinoma (BCC) surgery is radical excision of the tumour while maintaining eyelid functionality and facial aesthetics. Differences in management of the patients after excision of eyelid BCC with a narrow margin are described in the literature.

Aim: This study concerns the correlation between the recurrence rate in the periorbital area and the narrow safety margin of excision in the histopathological report with respect to various clinical and histopathological features. Read More

Arq Bras Oftalmol 2021 Feb 3. Epub 2021 Feb 3.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: This study aimed to optimize the effective doses of mitomycin C, 5-fluorouracil, and their combination on cultivated basal cell carcinoma.

Methods: Cultivated basal cell carcinoma and fibroblastic cells were treated with different concentrations of mitomycin C, 5-fluorouracil, and their combination. Cell viability, cell cycle, apoptosis, and expression levels of TP53, CDKN1A, and CDK6 were investigated. Read More

Am J Ophthalmol Case Rep 2021 Mar 5;21:100858. Epub 2020 Aug 5.

Department of Ophthalmology, Tung Wah Eastern Hospital, Hong Kong.

Purpose: Verruca Vulgaris is a common benign cutaneous lesion which only reported occasionally to have malignant potential. Our purpose is to report a rare case of verruca vulgaris involving the eyelid and subsequently transformed into the combination of squamous cell carcinoma and basal cell carcinoma.

Observations: We reported a case of a 97-year-old female with a chronic biopsy proven verruca vulgaris involving the left lateral canthus. Read More

Oman J Ophthalmol 2020 Sep-Dec;13(3):129-135. Epub 2020 Nov 2.

Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Purpose: To study the clinical profile and management outcomes of periocular basal cell carcinoma (BCC).

Materials And Methods: A retrospective analysis of all histopathologically proven cases of BCC between 1995 and 2015 was done. The demographic data, clinical presentation, histopathological subtype, and management outcomes were analyzed. Read More

BMJ Open 2021 01 26;11(1):e041854. Epub 2021 Jan 26.

Department of Ophthalmology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, China

Objectives: To describe the clinicopathological characteristics of patients with eyelid tumours and tumour-like lesions in South China, investigate possible factors affecting tumour constitution.

Design: Retrospective cohort study.

Setting: All patients diagnosed with eyelid tumours were included from a high-volume tertiary eye care centre from South China which caring for over 2000 patients per day. Read More

Ophthalmic Plast Reconstr Surg 2021 Jan 19. Epub 2021 Jan 19.

Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Oculoplastics, Wills Eye Hospital, Philadelphia, Pennsylvania Department of Ocular Pathology, Wills Eye Hospital, Philadelphia, Pennsylvania.

Carcinosarcoma is a malignant mixed tumor composed of epithelial and mesenchymal components which arises in a variety of tissues, including, in rare cases, the orbit. A 75-year-old male with a history of basal cell carcinoma of the left medial canthus, previously treated with surgical resection and adjuvant radiation therapy, presented with a recurrent 3 cm nodule of the left medial canthus. He underwent surgical resection of the left superior and inferior eyelid with pathology revealing invasive squamous cell carcinoma of upper and lower eyelids with deep orbital tissue involvement and undifferentiated pleomorphic sarcoma involving the dermis and periosteum, consistent with carcinosarcoma. Read More

J Cancer Res Ther 2020 Dec;16(Supplement):S48-S52

Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.

Context: Eyelid carcinoma is rare tumors of the head and neck. They are rarely lethal but can be associated with significant morbidity if not treated early and appropriately. There are limited data available from world over and in particular the Indian subcontinent regarding eyelid carcinoma and its prognostic factors influencing treatment outcomes. Read More

Rom J Ophthalmol 2020 Oct-Dec;64(4):414-418

Department of Plastic and Reconstructive Surgery, "Bagdasar-Arseni" Clinical Emergency Hospital, Bucharest, Romania.

The paper presents the reconstructive options of the lower eyelid region in patients who have benefited from the excision of basal cell carcinomas. The study was based on the clinical and evolutionary particularities analyzed in a series of cases, the patients benefiting from excision and reconstruction for the treatment of basal cell carcinomas located at the level of the orbital region. Following the surgical treatment, the local evolution was favorable with a good functional recovery. Read More

JAAD Case Rep 2021 Jan 6;7:14-16. Epub 2020 Nov 6.

Mountain West Dermatology, Grand Junction, Colorado.