Search Our Scientific Publications & Authors

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):718-723

Department of Otolaryngology, Guangdong Province Hospital of Integrated Traditional Chinese and Western Medicine, Foshan 528200, China.

To investigate the method and efficacy of reconstruction of facial skin defects after removing the lesions by applying the V-Y subcutaneous pedicle flap. A retrospective analysis was performed on 23 patients with facial reconstruction by using V-Y subcutaneous pedicle flap in the Otolaryngology Department of Guangdong Integrated Traditional Chinese and Western Medicine Hospital from March 2012 to April 2021. Patient ages ranged from 45 to 85 years old, with a mean age of 66. Read More

Ophthalmic Plast Reconstr Surg 2022 Jun 14. Epub 2022 Jun 14.

King Khaled Eye Specialty Hospital, Riyadh, Saudi Arabia.

Purpose: Pigmented basal cell carcinomas (PBCC) is an uncommon variant of basal cell carcinoma of the periocular region with limited information in the literature. We highlight the clinicopathological profile and somatic mutations in periocular PBCC.

Methods: The clinicopathological features and somatic mutations in patients with periocular PBCC were examined and compared with periocular non-PBCC reported in the literature. Read More

Jpn J Ophthalmol 2022 Jul 7;66(4):343-349. Epub 2022 Jun 7.

Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Purpose: To clarify the incidence and demographic characteristics of malignant eyelid tumors diagnosed in a single institute in Japan.

Study Design: Retrospective, observational case series METHODS: Patients with malignant eyelid tumors diagnosed histopathologically at Tokyo Medical University Hospital between 1995 and 2019 were reviewed retrospectively. The incidence and demographic profile of malignant eyelid tumors were analyzed. Read More

Dermatol Pract Concept 2022 May 1;12(2):e2022090. Epub 2022 Apr 1.

Department of Dermatology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

J Stomatol Oral Maxillofac Surg 2022 May 26. Epub 2022 May 26.

Department of Dermatology, Dijon Bourgogne University Hospital Center, 14 rue Paul Gaffarel, Dijon 21000, France.

Basal cell carcinoma (BCC) is locally aggressive and its prognosis depends on the risk of recurrence. The initial location of the tumor is a key criterion for calculating the risk of recurrence. The aim of this study was to evaluate the sites that appear to be most at risk of recurrence of BCC. Read More

Eye (Lond) 2022 May 25. Epub 2022 May 25.

James Paget University Hospital, Great Yarmouth, UK.

Background/objectives: To determine the incidence, proportion and location of periocular tumours in an English county over a five year period, and compare to other studies in the UK and worldwide.

Subjects/methods: A retrospective review of histopathology reports was performed for all periocular excision biopsies of malignancies from the county's three main hospitals over a 5-year period. These hospitals cover a population of just over one million. Read More

J Dermatol 2022 May 24. Epub 2022 May 24.

Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.

Despite rapid growth in the significance of dermoscopy in dermatological oncology, relatively little is yet known about the dermoscopic patterns of eyelid margin tumors. The aim of the study was to analyze the dermoscopic features of eyelid margin tumors. This was a retrospective, single-center, consecutive study which included clinical and dermoscopic analysis of eyelid margin tumors diagnosed at the Department of Dermatology, Venereology and Allergology at the Medical University of Gdańsk from 1 June 2016 to 31 December 2020. Read More

Saudi J Ophthalmol 2021 Jul-Sep;35(3):186-192. Epub 2022 Apr 18.

Department of Pathology, Queen Elizabeth II Health Sciences Center, Nova Scotia Health Authority (Central Zone), Halifax, Canada.

Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma with a high mortality rate. It typically affects elderly Caucasians, with a slight predilection for males. It is associated with chronic sun exposure and/or immunosuppression. Read More

Saudi J Ophthalmol 2021 Jul-Sep;35(3):257-260. Epub 2021 Nov 17.

Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.

A carcinosarcoma is a neoplasm with malignant epithelial and mesenchymal components. It is thought to arise by mesenchymal transformation of the epithelial elements. The cutaneous form of carcinosarcoma is rare and is associated with sun exposure; most cases arise in the head and neck. Read More

J Dtsch Dermatol Ges 2022 05 2;20(5):690-693. Epub 2022 May 2.

Department of Dermatology, Dermatosurgery and Allergology, Klinikum Bremen-Ost.

Eur J Ophthalmol 2022 Apr 4:11206721221086153. Epub 2022 Apr 4.

Oculoplastic, Orbital and Lacrimal Institute, Division of Ophthalmology, 26738Tel Aviv Ichilov Sourasky Medical Center, Tel Aviv, Israel.

Purpose: To report the epidemiology, indications and surgical outcomes of oculoplastic surgeries in older adults (≥ 90 years old).

Methods: A retrospective study was conducted reviewing the medical charts of 114 patients aged 90 years old and older who underwent oculoplastic procedures from 2010 to 2020. Data retrieved from the medical records included: past medical and ocular history, indication for surgery, type of surgery, intra and post-operative complications, pathological analysis for removed tissues, and surgical outcome in the last follow-up. Read More

JPRAS Open 2022 Jun 10;32:88-92. Epub 2022 Mar 10.

Department of Plastic and Reconstructive Surgery, Kansai Medical University, Osaka, Japan.

We herein report a 57-year-old man afflicted with multiple malignant tumors arising from a giant sebaceous nevus on his left parieto-temporal scalp and neck. The upper eyelid was resected in all layers, and the auricle was resected as well, leaving part of the external auricular cartilage; the parotid gland area was also resected over the parotid fascia. The lost part of the left eyebrow was reconstructed using an anterior forehead skin flap, and the residual defect was covered with skin graft and expanded scalp flap. Read More

Neurosignals 2022 03;30(S1):1-10

U.O.C. Oncologia Oculare, Dipartimento di Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa Collo, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

The goal of radiotherapy in the treatment of eyelid and ocular surface tumors is to eradicate tumor burden in a manner that maintains visual function and preserve surrounding sensitive ocular tissue. Interventional radiotherapy (IRT-brachytherapy) is a radiotherapy technique associated with a highly focal dose distribution, with the advantage of boosting limited size target volumes to very high dose while sparing normal tissue. The reduction in the ocular and adnexal complications that result from this form of therapy, has led in recent years, to an increase in the use of IRT for the treatment of eyelid and ocular surface tumors. Read More

Sci Rep 2022 03 22;12(1):4891. Epub 2022 Mar 22.

Department of Burn Plastic and Aesthetic Surgery, General Hospital of Ningxia Medical University, No. 804, Shengli South Street, Xingqing District, Yinchuan, 750001, China.

Large eyelid defect after excision of malignancies or trauma is difficult to reconstruct due to special structure and function of the eyelid. In this study, we aimed to present the outcomes of subcutaneous pedicled propeller flap for reconstructing the large eyelid defect after excision of malignancies or trauma. A retrospective review of patients diagnosed with eyelid defect due to excision of malignancies or trauma, and undergoing subcutaneous pedicled propeller flap for reconstructing the large eyelid defect, was conducted at our hospital. Read More

Plast Reconstr Surg Glob Open 2022 Mar 17;10(3):e4147. Epub 2022 Mar 17.

Department of Dermatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Various reconstructive procedures have been reported for full-thickness defects of the lower eyelid after tumor excision or trauma. In eyelid reconstruction, not only functionality but also cosmetic results are important; furthermore, making scars inconspicuous is challenging. The purpose of this study is to make the scars less noticeable in lower eyelid reconstruction. Read More

SAGE Open Med Case Rep 2022 5;10:2050313X221082435. Epub 2022 Mar 5.

Department of Dermatology, Royal Free London NHS Foundation Trust, London, UK.

Orange palpebral spots are described as bilateral, ovoid, poorly defined orange-yellow macules on the superior eyelid and are predominantly reported in Caucasian populations. Previous reports have found correlations with melatonin incontinence secondary to trauma, lipofuscin accumulation in patients with superficial fatty tissue and palpebral thinness, and vitamin E, carotenoid and beta-cryptoxanthin levels. We present, to our knowledge, the first case of orange palpebral spots reported in the United Kingdom, in a patient with a background of atopy, significant sun exposure, bilateral cataracts and retinal detachment. Read More

J Skin Cancer 2022 18;2022:4075668. Epub 2022 Feb 18.

Department of Pathology, Northern International Medical College, Dhaka, Bangladesh.

Background: Eyelid tumours are common in our ophthalmic practice. Malignancy cases account only for one-fourth of all eyelid tumours. The most aggressive eyelid malignancy is sebaceous gland carcinoma, but its occurrences are rare in western countries. Read More

Arq Bras Oftalmol 2022 Feb 14. Epub 2022 Feb 14.

Department of Ophthalmology, Universidade de São Paulo, São Paulo, SP, Brazil.

Purpose: To evaluate the variables possibly related to actinic keratosis and malignant skin lesions on the eyelid.

Methods: A prospective study of patients with suspected eyelid malignancy was conducted. The participants underwent a 2-mm punch biopsy at two opposite sites of the lesion for diagnosis, and the results were compared with those of the histopathological study of the surgical excised specimen. Read More

Biomed Opt Express 2022 Jan 17;13(1):410-425. Epub 2021 Dec 17.

Ophthalmology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.

Radical excision of periorbital skin tumors is difficult without sacrificing excessive healthy tissue. Photoacoustic (PA) imaging is an emerging non-invasive biomedical imagi--ng modality that has potential for intraoperative micrographic control of surgical margins. This is the first study to assess the feasibility of PA imaging for the detection of periocular skin cancer. Read More

Int Ophthalmol 2022 Jun 28;42(6):1867-1874. Epub 2022 Jan 28.

Department of Ophthalmology and Visual Sciences, Division of Ophthalmic Plastic and Reconstructive Surgery, Paulista School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.

Objective: The incidence of malignant eyelid tumors is considerably increasing, even in young patients. The purpose of this study was to identify particularities in individuals under 40 years of age affected by eyelid malignancies.

Methods: Clinical charts of patients under 40 years of age who underwent eyelid tumor excision from 2014 to 2020 in two reference centers, one in Brazil and one in the USA, were reviewed. Read More

Diagnostics (Basel) 2022 Jan 7;12(1). Epub 2022 Jan 7.

Anatomic Pathology Service, Pathology Department, Centro Hospitalar e Universitário do Porto, Largo Professor Abel Salazar, 4099-001 Porto, Portugal.

Basaloid follicular hamartoma (BFH) is a normally benign, uncommon, malformative lesion involving the hair follicles, which usually poses challenges in the differential diagnosis with other benign and malignant tumours, especially basal cell carcinoma, due to significant clinical and morphological overlap. Here, we report the case of a 53-year-old male who presented with a mass in the upper left eyelid evolving for one year. The patient had a previous history of total colectomy and an abdominal desmoid tumour within the context of Familial Adenomatous Polyposis (FAP), with a documented germline mutation in the Adenomatous Polyposis Coli (APC) gene. Read More

Cureus 2022 Jan 4;14(1):e20922. Epub 2022 Jan 4.

Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.

Background The majority of eyelid tumours are benign in nature and constitute 82%-98% of all eyelid tumours. This study aimed to explore the prevalence and frequency of histopathological diagnoses of eyelid tumours encountered in Hospital Sultanah Bahiyah (HSB), Malaysia, from 2016 to 2020. Method This study is a case series of 136 patients with eyelid tumours who underwent eyelid biopsy. Read More

Dermatol Reports 2021 Nov 5;13(3):9240. Epub 2021 Aug 5.

Medical Oncology, AOUC Hospital, Florence, Italy.

The management of difficult-to-treat periocular basal cell carcinoma (BCC) becomes very challenging in cases of delayed diagnosis, leading to the development of locally advanced BCC. The aim of this study was to evaluate the outcomes of Hedgehog pathway inhibitors (vismodegib and sonidegib) treatment in patients affected by periocular locally advanced BCC. We focused on the common adverse events and their correlation with the administration schedule, to determine a management protocol specific for the periocular area. Read More

Proc (Bayl Univ Med Cent) 2022 23;35(1):76-77. Epub 2021 Aug 23.

Department of Dermatology, Texas Tech Health Sciences Center, Lubbock, Texas.

Basal cell carcinomas have been reported to arise within several different tumors. Without careful attention to detail, basal cell carcinomas may go unnoticed when presenting within or directly adjacent to another distinct tumor. The increased use and accessibility of dermoscopy has allowed dermatologists to detect skin cancers that might otherwise be undetected by the naked eye. Read More

Indian J Ophthalmol 2022 Jan;70(1):281-286

Department of Ophthalmology, Medical University Pleven, Pleven, Bulgaria.

Facial skin defect reconstruction in medial-canthal area of the lids can be a challenge even when performed by a skilled surgeon. The excision of large tumors in this area leads to significant surgical defects that cannot be repaired by merely closing the wound. The glabellar area provides a source of redundant skin with similar characteristics to that of the medial-canthal lid area. Read More

Indian J Ophthalmol 2022 Jan;70(1):43-50

Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India.

Purpose: : To study the epidemiological pattern and diagnostic accuracy of histopathologically proven eyelid lesions over a period of two decades.

Methods: : A retrospective study of all histopathologically proven eyelid lesions from April 1996 to March 2016 was conducted. The lesions were broadly categorized as benign or malignant. Read More

Oman J Ophthalmol 2021 Sep-Dec;14(3):153-156. Epub 2021 Oct 20.

Department of Eyesmart EMR and AEye (AVD), LV Prasad Eye Institute, Hyderabad, Telangana, India.

Objective: The objective of this study was to describe the eye tumors in Asian Indian geriatric population (age >60 years) presenting to a multitier ophthalmology hospital network in India.

Methods: This was a retrospective study of 855 Asian Indian geriatric patients.

Results: During the 3-year study period, 855 geriatric patients were diagnosed with eye tumors. Read More

Ophthalmologe 2022 Mar 3;119(3):234-239. Epub 2021 Dec 3.

Poliklinik und Klinik, Universitätsmedizin Mainz, Langenbeckstr 1, 55131, Mainz, Deutschland.

Background: By identifying diseases of the anterior segment of the eye associated with exposure to UV light, recommendations for action can be derived.

Aim: After reading this review, the reader should be familiar with UV light-associated diseases of the anterior segment of the eye.

Method: Using a selective literature search, UV light-associated diseases of the anterior segment of the eye were identified and protective mechanisms are described. Read More

J Eur Acad Dermatol Venereol 2022 Jan;36 Suppl 1:59-62

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Cutaneous squamous cell carcinoma (cSCC) is the most common tumour entity that grows secondarily into the orbital area, while basal cell carcinoma (BCC) is the most common periocular and eyelid tumour. Diagnostic delays are common and may increase post-treatment complications. The therapy is challenging and must be discussed at an interdisciplinary tumour board. Read More