5,397 results match your criteria Basal Cell Carcinoma* Dermatology


Nonvascular uses of pulsed dye laser in clinical dermatology.

J Cosmet Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Dermatological Surgery & Laser Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

Lasers are fast becoming the vogue of dermatology ranging from ablative, nonablative, fractional photothermolysis to vascular lasers. There are a range of vascular lasers including potassium titanyl phosphate (KTP 532 nm), pulsed dye laser (PDL -595 nm), diode (810 nm), and Nd:YAG (1064 nm). PDL is a laser that emits yellow light using Rhodamine dye as it is lasing medium. Read More

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http://dx.doi.org/10.1111/jocd.12924DOI Listing

Correction to: Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study.

BMC Cancer 2019 Apr 18;19(1):366. Epub 2019 Apr 18.

Universitätsklinikum Schleswig-Holstein, Schittenhelmstr, 7, D-24 105, Kiel, Germany.

Following publication of the original article [1], it was reported that the legend for Fig. 1 was incomplete. The complete figure legend is. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5568-6DOI Listing
April 2019
1 Read

A novel splicing mutation of PTCH1 in a Chinese family with nevoid basal cell carcinoma syndrome.

Med Mol Morphol 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disease characterized by the development of multiple jaw keratocysts and basal cell carcinomas (BCC) and accompanied by diverse phenotypes. The establishment of diagnosis lies on the identification of a heterozygous germline pathogenic variant in the patched homolog 1 gene (PTCH1). PTCH1 has alternative splicing and selective initial coding exon, leading to three types of encoding proteins (PTCHL, PTCHM and PTCHS). Read More

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http://link.springer.com/10.1007/s00795-019-00222-9
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http://dx.doi.org/10.1007/s00795-019-00222-9DOI Listing
April 2019
2 Reads

Unusual presentation of dermatofibroma on the face: Case report.

Clin Case Rep 2019 Apr 19;7(4):672-674. Epub 2019 Feb 19.

Department of Dermatology, College of Medicine King Khalid University Hospital Riyadh Saudi Arabia.

Dermatofibroma (DF; Benign Fibrous Histiocytoma) seldom presents on the face. We present an unusual case presentation of translucent nodule on the upper right cheek of the face which was diagnosed clinically as basal cell carcinoma. Physician should include DF in the differential of such lesions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2066
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http://dx.doi.org/10.1002/ccr3.2066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452477PMC
April 2019
2 Reads

Variance of Basal Cell Carcinoma Subtype Reporting by Practice Setting.

JAMA Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, University of Southern California, Los Angeles.

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2019.0066DOI Listing
April 2019
2 Reads

Basal Cell Carcinoma on a Nevus Sebaceous of Jadassohn: A Case Report.

J Clin Aesthet Dermatol 2019 Mar 1;12(3):40-43. Epub 2019 Mar 1.

Drs. Paninson, Trope, and Ramos-e-Silva are with the Sector of Dermatology, Postgraduation Course in Dermatology at the University Hospital and School of Medicine, Federal University of Rio de Janeiro in Rio de Janeiro, Brazil.

The nevus sebaceous of Jadassohn, usually present at birth, is a hamartoma composed predominantly of sebaceous glands, which can progress to benign and malignant tumors. Malignant neoplasms on the nevus sebaceous occur in about 2.5 percent of cases, with basal cell carcinoma accounting for 1. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440703PMC
March 2019
2 Reads

Depth of Invasion of Aggressive and Nonaggressive Basal Cell Carcinoma.

J Clin Aesthet Dermatol 2019 Mar 1;12(3):12-14. Epub 2019 Mar 1.

Drs. Wetzel and Haeberle and Mr. Brown are with the Division of Dermatology, Department of Medicine, University of Louisville School of Medicine in Louisville, Kentucky.

Dermal invasion is characteristic of more aggressive basal cell carcinoma (BCC) tumors. However, reporting the depth of invasion of BCC is not currently a standard or recommended practice. The purpose of this study was to document the depth of invasion of BCC. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440705PMC
March 2019
1 Read

A Retrospective Study of the Diagnostic Accuracy of In Vivo Reflectance Confocal Microscopy for Basal Cell Carcinoma Diagnosis and Subtyping.

J Clin Med 2019 Apr 3;8(4). Epub 2019 Apr 3.

Department of Dermatology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Current national and European guidelines recommend distinct management approaches for basal cell carcinoma (BCC) based on tumor location, size, and histopathological subtype. In vivo reflectance confocal microscopy (RCM) is a non-invasive skin imaging technique which may change the diagnostic pathway for BCC patients. This study aimed to determine the sensitivity and specificity of RCM for BCC diagnosis, assess the predictive values of several confocal criteria in correctly classifying BCC subtypes, and evaluate the intraobserver reliability of RCM diagnosis for BCC. Read More

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http://dx.doi.org/10.3390/jcm8040449DOI Listing
April 2019
1 Read

A Collision Tumor: Reflectance Confocal Microscopy Features and Correlation between Dermoscopy and Histopathology.

Indian J Dermatol 2019 Mar-Apr;64(2):155-157

Department of Pathology, Istanbul Training and Research Hospital, Istanbul, Turkey.

Coexistence of two types of malignant neoplasms, called 'a collision tumor,' is relatively uncommon. Basal cell carcinomas (BCCs) are known to coexist with other cutaneous lesions, but the collision of BCC with malignant melanoma is rare. We report a rare case of BCC with underlying lentigo maligna melanoma, focusing on dermoscopic and reflectance confocal microscopic (RCM) findings and their correlation with histopathology. Read More

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http://www.e-ijd.org/text.asp?2019/64/2/155/254153
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http://dx.doi.org/10.4103/ijd.IJD_278_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440176PMC
April 2019
2 Reads

A diagnostic challenge: inflamed and pigmented seborrheic keratosis. Clinical, dermoscopic, and histopathological correlation.

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Baskent University Istanbul Hospital Dermatology Clinic, Istanbul.

Pigmented and irritated types of seborrheic keratosis (SK) can be confused with melanoma, basal cell carcinoma, or pigmented actinic keratosis. Dermoscopic examination may give many clues for the diagnosis of SK, but in equivocal cases the accurate diagnosis can only be made by microscopic features. Herein, we report a striking, isolated pigmented and inflamed SK, located on the waist in an elderly man. Read More

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March 2019
2 Reads

Complete healing of basal cell carcinoma under bendamustine and brentuximab vedotin therapy in a patient with cutaneous lymphoma.

Dermatol Ther 2019 Apr 12:e12934. Epub 2019 Apr 12.

Department of Pathology, Istanbul Faculty of Medicine, Istanbul University.

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http://dx.doi.org/10.1111/dth.12934DOI Listing
April 2019
1 Read

Giant basal cell carcinoma: clinical-histological characteristics of 115 cases.

Int J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Medical Research Division, UMAE Hospital de Pediatria CMNO, IMSS, Guadalajara, Jalisco, Mexico.

Introduction: Giant basal cell carcinoma (GBCC) is a tumor ≥5 cm in size, with aggressive biological behavior, that represents 1% of basal cell carcinomas (BCC), and studies regarding it are scarce. Our objective was to investigate the clinical-histopathological characteristics of GBCC and the risk factors associated with its development.

Methods: A retrospective study over 8 years included patients with the clinical and histopathological diagnosis of GBCC. Read More

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http://dx.doi.org/10.1111/ijd.14455DOI Listing
April 2019
4 Reads

Upregulation of SNAI2 and SOX9 mRNA versus downregulation of eight other EMT/stemness related genes in Basal Cell Carcinoma.

Br J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Medical Genetics Department, School of Medicine, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, 14176-13151, Iran.

Basal Cell Carcinoma (BCC) is the most common malignancy among fair-skinned people. In contrast to other types of cancer, BCC has the lowest rate of metastasis and mortality. Although several molecular signaling pathways have been documented to play a role in BCC formation, the molecular mechanism to explain why BCC is distinctively rarely metastatic has not been elucidated yet. Read More

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http://dx.doi.org/10.1111/bjd.17995DOI Listing
April 2019
1 Read

Quality of life measurement in skin cancer patients: literature review and position paper of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes, Melanoma and Non-Melanoma Skin Cancer.

J Eur Acad Dermatol Venereol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology and Wound Healing, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.

The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient Oriented Outcomes, Melanoma and Non-Melanoma Skin Cancer (NMSC) present a review of the literature and position statement on health-related (HR) QoL assessment in skin cancer patients. A literature search was carried out to identify publications since 1980 that included information about the impact of SC on QoL. Generic, dermatology-specific, cancer-specific, SC-specific, facial SC-specific, NMSC-specific, basal cell carcinoma-specific and melanoma-specific QoL questionnaires have been used to assess HRQoL in SC patients. Read More

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http://dx.doi.org/10.1111/jdv.15487DOI Listing
April 2019
1 Read

Reflectance Confocal Microscopy made easy: the four must-know key features for the diagnosis of melanoma and non-melanoma skin cancers.

J Am Acad Dermatol 2019 Apr 4. Epub 2019 Apr 4.

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy; Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Centro Oncologico ad Alta Tecnologia Diagnostica-Dermatologia, Reggio Emilia, Italy.

Background: Reflectance confocal microscopy (RCM)-based skin cancer diagnosis requires proficiency.

Aims: To identify a shortlist of key RCM features of skin cancers and test their diagnostic utility.

Methods: We identified key RCM features through consensus among six experts using a modified-Delphi method. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.085DOI Listing

Incidence of complications in dermatological surgery of melanoma and non-melanoma skin cancer in patients with multiple comorbidity and/or antiplatelet-anticoagulants. Five year experience in our Hospital.

Cir Cir 2019 ;86(1):15-23

Dermatology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico City. Mexico.

Introduction: Surgery is performed more frequently now at days, due to the increasing incidence of melanoma and no-melanoma skin cancer. There are different opinions among dermatologic surgeons between to continue or discontinue antithrombotic therapy prior to the procedure, which increases the risk of thromboembolic events. Prophylaxis with oral antibiotics in the postsurgical period is controversial. Read More

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http://dx.doi.org/10.24875/CIRUE.M18000003DOI Listing
January 2019
1 Read

Vascular patterns in basal cell carcinoma: Dermoscopic, confocal and histopathological perspectives.

Oncol Lett 2019 May 25;17(5):4112-4125. Epub 2019 Feb 25.

Department of Dermatology, 'Prof. N. Paulescu' National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania.

Basal cell carcinoma (BCC) is the most prevalent skin cancer in the Caucasian population. A variety of different phenotypic presentations of BCC are possible. Although BCCs rarely metastasize, these tumors commonly destroy underlying tissues and should therefore be treated promptly. Read More

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http://www.spandidos-publications.com/10.3892/ol.2019.10070
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http://dx.doi.org/10.3892/ol.2019.10070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444327PMC
May 2019
3 Reads

The effectiveness of imiquimod 5% cream as an anti-wrinkle treatment: A pilot study.

Authors:
Saad Altalhab

J Cosmet Dermatol 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, College of Medicine, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

Background: Imiquimod 5% cream is currently approved to treat several dermatologic conditions including actinic keratoses (AK), superficial basal cell carcinoma (sBCC), and genital warts. However, there are numerous studies published on the alternative off-label uses of imiquimod cream. Photoaging of facial skin is an important use for topical skin treatments, yet few studies have evaluated the effect of imiquimod cream for this dermatological condition. Read More

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http://dx.doi.org/10.1111/jocd.12939DOI Listing
April 2019
5 Reads

Commentary on Clinical Characteristics of Basal Cell Carcinoma in African Americans.

Dermatol Surg 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1097/DSS.0000000000001950DOI Listing
March 2019
8 Reads

Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Study.

Dermatology 2019 Apr 2:1-6. Epub 2019 Apr 2.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland,

Background: Due to the importance of function and cosmetics, periocular skin malignancies represent a therapeutic challenge.

Objective: To evaluate the safety and efficacy of radiotherapy (RT) treating periocular skin tumors.

Methods: Data of patients with periocular tumors treated with grenz or soft X-rays at the University Hospital Zurich, Switzerland, between 2009 and 2014 were reviewed. Read More

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http://dx.doi.org/10.1159/000496539DOI Listing
April 2019
4 Reads

Aberrant expression and high-frequency mutations of in nonmelanoma skin cancer.

Exp Ther Med 2019 Apr 12;17(4):2746-2756. Epub 2019 Feb 12.

Department of Dermatology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518100, P.R. China.

Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) have exhibited a marked increase in incidence in previous decades and are the most common malignancies in Caucasian populations. Src homology 3 and multiple ankyrin repeat domains protein-associated RH domain-interacting protein (SHARPIN) has been identified as a commonly overexpressed proto-oncogene in several types of visceral cancer. However, to the best of our knowledge, the functions of SHARPIN in nonmelanoma skin cancer (NMSC) have not been described. Read More

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http://www.spandidos-publications.com/10.3892/etm.2019.7261
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http://dx.doi.org/10.3892/etm.2019.7261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434243PMC
April 2019
7 Reads

Immunotherapy in non-melanoma skin cancer: updates and new perspectives.

Drugs Context 2019 25;8:212583. Epub 2019 Mar 25.

Department for Dermatology, Venerology and Allergology, University Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.7573/dic.212583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434981PMC
March 2019
5 Reads

Sunscreen May Prevent the Development of Basal Cell Carcinoma in Individuals with Basal Cell Carcinoma Nevus Syndrome (BCCNS): A Retrospective Survey Study.

J Am Acad Dermatol 2019 Mar 27. Epub 2019 Mar 27.

University of Connecticut Health Center Dermatology Department. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.03.057DOI Listing
March 2019
2 Reads

Non-Melanoma Skin Cancer Tumor's Characteristics and Histologic Subtype as a Predictor for Subclinical Spread and Number of Mohs Stages required to Achieve Tumor-Free Margins.

P R Health Sci J 2019 Mar;38(1):40-45

Department of Dermatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.

Objective: To describe the behavior of non-melanoma skin cancer (NMSC) based on tumor's characteristics.

Methods: A total of 219 of NMSC were analyzed via a retrospective medical chart review. The data obtained from each record included but was not limited to: number of Mohs micrographic surgery (MMS) stages required for tumor clearance, defect size, repair type and size according to the neoplasm's histopathologic subtype. Read More

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March 2019
4 Reads

Genome-wide association studies and polygenic risk scores for skin cancer: clinically useful yet?

Br J Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Cancer Biology and Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH.

Background: Genome-wide association studies (GWAS) have identified thousands of susceptibility variants, though most have been associated with small individual risk estimates that offer little predictive value. However, combining multiple variants into polygenic risk scores (PRS) may be more informative. Multiple studies have developed PRS composed of GWAS-identified variants for cutaneous cancers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17917
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http://dx.doi.org/10.1111/bjd.17917DOI Listing
March 2019
5 Reads

Ultrasound Diagnosis of Infiltrative Versus Noninfiltrative Subtypes of Cutaneous Basal Cell Carcinoma.

Authors:
Ximena Wortsman

J Ultrasound Med 2019 Mar 23. Epub 2019 Mar 23.

Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues Clinic, Department of Dermatology, University of Chile and Pontifical Catholic University of Chile, Santiago, Chile.

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http://dx.doi.org/10.1002/jum.14994DOI Listing
March 2019
1 Read

Basal Cell Carcinoma Associated with Secondary Localized Cutaneous Amyloid Deposits: Case Report and Review.

Authors:
Philip R Cohen

Cureus 2019 Jan 14;11(1):e3879. Epub 2019 Jan 14.

Dermatology, San Diego Family Dermatology, San Diego, USA.

Amyloid deposition has been observed in tissue specimens of basal cell carcinomas. A 68-year-old man with a nodular basal cell carcinoma on his left arm near the elbow is described; microscopic evaluation of the biopsy tissue specimen shows not only nodular aggregates and strands of atypical basaloid tumor cells but also marked deposition of amorphous amyloid material in the stroma between the aggregates of basal cell carcinoma. Including the man in this report, there are additional individual descriptions of patients whose basal cell carcinomas have amyloid deposits in the adjacent stroma or within the tumor aggregates or both. Read More

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http://dx.doi.org/10.7759/cureus.3879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420332PMC
January 2019
6 Reads

Skin cancer precursor immunotherapy for squamous cell carcinoma prevention.

JCI Insight 2019 Mar 21;4(6). Epub 2019 Mar 21.

Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: Topical calcipotriol plus 5-fluorouracil (5-FU) combination is an effective immunotherapy against actinic keratosis (AK), which is a precursor to squamous cell carcinoma (SCC). However, the long-term effectiveness of calcipotriol plus 5-FU treatment for SCC prevention is unknown.

Methods: We performed a blinded prospective cohort study on participants of a randomized double-blind clinical trial in which a 4-day course of topical calcipotriol plus 5-FU combination was compared to Vaseline plus 5-FU (control) for AK treatment. Read More

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http://dx.doi.org/10.1172/jci.insight.125476DOI Listing
March 2019
2 Reads

Cutaneous Tumour of the Left Cricothyroid Area!?

Open Access Maced J Med Sci 2019 Feb 25;7(4):698-699. Epub 2019 Feb 25.

Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic surgery, General Skobelev 79, 1606 Sofia.

Background: The cricothyroid area is an atypical localisation for placement of basal cell carcinomas. The main differential diagnosis for cutaneous tumours in this area is between BCC, spinocellular carcinoma and melanoma. The area is problematic about the choice of therapeutic approach, especially in the case of a vague clinical tumour type accompanied by enlarged lymph nodes in the immediate proximity. Read More

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http://dx.doi.org/10.3889/oamjms.2019.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420945PMC
February 2019
1 Read

Long-term experience with radiotherapy for the treatment of non-melanoma skin cancer.

J Dermatolog Treat 2019 Mar 20:1-6. Epub 2019 Mar 20.

c Department of Dermatology , Radboud University Medical Center , Nijmegen , Netherlands.

Purpose: In the Netherlands, the incidence of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin is increasing dramatically. Radiotherapy is one of the treatment options, especially for the high risk and the irradical excised tumours.

Methods: Retrospectively, the treatment outcome of all patients with BCC or SCC treated with radiotherapy in the period 2000-2013, were reviewed. Read More

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http://dx.doi.org/10.1080/09546634.2019.1592099DOI Listing
March 2019
3 Reads

Genes or environment: what counts most in basal cell carcinoma?

J Eur Acad Dermatol Venereol 2019 Mar;33(3):461

Dermatology Unit, University of Campania, Naples, Italy.

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http://dx.doi.org/10.1111/jdv.15486DOI Listing
March 2019
6 Reads

Substitution of low-risk skin cancer hospital care towards primary care: A qualitative study on views of general practitioners and dermatologists.

PLoS One 2019 19;14(3):e0213595. Epub 2019 Mar 19.

Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

Background: Rising healthcare expenditures places the potential for substitution of hospital care towards primary care high on the political agenda. As low-risk basal cell carcinoma (BCC) care is one of the potential targets for substitution of hospital care towards primary care the objective of this study is to gain insight in the views of healthcare professionals regarding substitution of skin cancer care, and to identify perceived barriers and potential strategies to facilitate substitution.

Methods: A qualitative study was conducted consisting of 40 interviews with dermatologists and GPs and three focus groups with 18 selected GPs with noted willingness regarding substitution of skin cancer care. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213595PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424446PMC
March 2019
1 Read

Characterisation of resistance mechanisms developed by basal cell carcinoma cells in response to repeated cycles of Photodynamic Therapy.

Sci Rep 2019 Mar 18;9(1):4835. Epub 2019 Mar 18.

Biology Department, Faculty of Sciences, Autonomous University of Madrid, Madrid, Spain.

Photodynamic Therapy (PDT) with methyl-aminolevulinate acid (MAL-PDT) is being used for the treatment of Basal cell carcinoma (BCC), but recurrences have been reported. In this work, we have evaluated resistance mechanisms to MAL-PDT developed by three BCC cell lines (ASZ, BSZ and CSZ), derived from mice on a ptch+/- background and with or without p53 expression, subjected to 10 cycles of PDT (10G). The resistant populations showed mesenchymal-like structure and diminished proliferative capacity and size compared to the parental (P) cells. Read More

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http://dx.doi.org/10.1038/s41598-019-41313-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423284PMC
March 2019
1 Read

Mutant Lef1 controls Gata6 in sebaceous gland development and cancer.

EMBO J 2019 Mar 18. Epub 2019 Mar 18.

Centre for Stem Cells and Regenerative Medicine, King's College London, London, UK

Mutations in Lef1 occur in human and mouse sebaceous gland (SG) tumors, but their contribution to carcinogenesis remains unclear. Since Gata6 controls lineage identity in SG, we investigated the link between these two transcription factors. Here, we show that Gata6 is a β-catenin-independent transcriptional target of mutant Lef1. Read More

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http://dx.doi.org/10.15252/embj.2018100526DOI Listing

Telomeres and Telomerase in Cutaneous Squamous Cell Carcinoma.

Int J Mol Sci 2019 Mar 16;20(6). Epub 2019 Mar 16.

Department of Dermatology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, 67100 L'Aquila, Italy.

The role of telomere biology and telomerase activation in skin cancers has been investigated in melanoma and basal cell carcinoma but limited evidence is available for cutaneous squamous cell carcinoma (cSCC). We will review the current knowledge on the role of telomere and telomerase pathway in cSCC pathogenesis. At the somatic level, both long and short telomere lengths have been described in cSCC. Read More

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http://dx.doi.org/10.3390/ijms20061333DOI Listing
March 2019
1 Read

Nonmelanoma Skin Cancer in Childhood and Young Adult Cancer Survivors Previously Treated With Radiotherapy.

J Natl Compr Canc Netw 2019 Mar;17(3):237-243

dAdult Long-Term Follow-Up Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, and.

Background: Radiotherapy (RT) is a risk factor for nonmelanoma skin cancer (NMSC), specifically basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), but whether features, histology, or recurrence of NMSC after RT resemble those observed in the general population is unknown.

Methods: A retrospective review (1994-2017) was performed within the Adult Long-Term Follow-Up Program and Dermatology Service at Memorial Sloan Kettering Cancer Center. Demographics, clinical features, histology, treatment, and recurrence were collected for this patient cohort that was under close medical surveillance. Read More

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http://dx.doi.org/10.6004/jnccn.2018.7096DOI Listing
March 2019
1 Read

Nonmelanoma Skin Cancer Frequency and Risk Factors in Australian Heart and Lung Transplant Recipients.

JAMA Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Dermatology, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia.

Importance: There is limited research examining the incidence of nonmelanoma skin cancer (NMSC) in heart and lung transplant recipients in Australia.

Objective: To determine the frequency of and risk factors for NMSC in a cohort of Australian heart and lung transplant recipients.

Design, Setting, And Participants: A retrospective cohort study was conducted at an Australian tertiary center where heart and lung transplants are performed between March 21 and December 14, 2016. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.4789DOI Listing
March 2019
1 Read

Epidemiology of basal and cutaneous squamous cell carcinoma in the United Kingdom 2013-2015: a cohort study.

Br J Dermatol 2019 Mar 12. Epub 2019 Mar 12.

Barts and The London School of Medicine and Dentistry, London, UK.

Background: Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), together known as keratinocyte cancers (KCs), are the commonest cancer in Caucasian populations. Recent improvements to registry data collection in England has allowed more accurate analysis of the epidemiology of BCC and cSCC and for the first time we are able to provide an accurate (representative) tumour burden for KC in the UK.

Objective: To estimate the incidence of BCC and cSCC in the UK. Read More

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http://dx.doi.org/10.1111/bjd.17873DOI Listing
March 2019
1 Read
4.275 Impact Factor

Electrochemotherapy in the treatment of locally advanced or recurrent eyelid-periocular basal cell carcinomas.

Sci Rep 2019 Mar 12;9(1):4285. Epub 2019 Mar 12.

Department of Ophthalmology, University of Szeged, Szeged, Hungary.

There is increasing evidence about the effectiveness of electrochemotherapy (ECT) in the treatment of basal cell carcinomas in the head and neck region, although its role in the management of eyelid-periocular skin tumors has to be clarified. The aim of the present study is to evaluate the results of ECT in the treatment of locally advanced primary and recurrent eyelid-periocular skin basal cell carcinomas. Twelve patients with basal cell carcinoma involving the eyelid-periocular skin region were treated with ECT. Read More

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http://dx.doi.org/10.1038/s41598-019-41026-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414678PMC
March 2019
1 Read

Global gene expression of histologically normal primary skin cells from BCNS subjects reveals "single-hit" effects that are influenced by rapamycin.

Oncotarget 2019 Feb 15;10(14):1360-1387. Epub 2019 Feb 15.

Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

Studies of dominantly heritable cancers enabled insights about tumor progression. BCNS is a dominantly inherited disorder that is characterized by developmental abnormalities and postnatal neoplasms, principally BCCs. We performed an exploratory gene expression profiling of primary cell cultures derived from clinically unaffected skin biopsies of BCNS gene-carriers () and normal individuals. Read More

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http://dx.doi.org/10.18632/oncotarget.26640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402716PMC
February 2019
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Patient indications for Mohs micrographic surgery: a clinical practice guideline.

Curr Oncol 2019 Feb 1;26(1):e94-e99. Epub 2019 Feb 1.

Department of Medical Oncology, Odette Cancer Centre, Toronto, ON.

Objective: The purpose of the present work was to develop evidence-based indications for Mohs micrographic surgery in patients with a diagnosis of skin cancer.

Methods: The guideline was developed by Cancer Care Ontario's Program in Evidence-Based Care, together with the Melanoma Disease Site Group and the Surgical Oncology Program, through a systematic review of relevant literature, patient- and caregiver-specific consultation, and internal and external reviews.

Recommendation 1: Given a lack of high-quality, comparative evidence, surgery (with postoperative or intraoperative margin assessment) or radiation (for those who are ineligible for surgery) should remain the standard of care for patients with skin cancer. Read More

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http://dx.doi.org/10.3747/co.26.4439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380643PMC
February 2019
2 Reads

Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1.

BMJ Case Rep 2019 Mar 8;12(3). Epub 2019 Mar 8.

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

A man in his early 60s with myotonic dystrophy type 1 (DM1) and an extensive history of non-melanoma skin cancer presented with multiple pearly, erythematous papules on his face, head, trunk and extremities, clinically consistent with basal cell carcinoma (BCC). Due to the numerous BCC and history of multiple and early-onset BCC, examination was concerning for a hereditary BCC syndrome. Subsequent histopathology confirmed BCC. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22723
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http://dx.doi.org/10.1136/bcr-2018-227233DOI Listing
March 2019
8 Reads

'Eternal sunshine of the spotless islands': how dermoscopy may influence confocal microscopy when dealing with squamous cells carcinoma simulating basal cell carcinoma.

J Eur Acad Dermatol Venereol 2019 Mar 9. Epub 2019 Mar 9.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Viale Risorgimento, 80, 42123, Reggio Emilia, Italy.

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http://dx.doi.org/10.1111/jdv.15553DOI Listing
March 2019
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Common skin bacteria protect their host from oxidative stress through secreted antioxidant RoxP.

Sci Rep 2019 Mar 5;9(1):3596. Epub 2019 Mar 5.

Division of Infection Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Cutibacterium acnes is an abundant skin commensal with several proposed mutualistic functions. A protein with strong antioxidant activity was recently identified from the C. acnes secretome. Read More

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http://dx.doi.org/10.1038/s41598-019-40471-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401081PMC
March 2019
4 Reads

Coming into focus: Dermoscopy for basal cell carcinomas.

Authors:
Warren R Heymann

J Am Acad Dermatol 2019 May 2;80(5):1254-1255. Epub 2019 Mar 2.

Division of Dermatology, Cooper Medical School of Rowan University, Marlton, New Jersey. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.02.059DOI Listing
May 2019
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Gossypetin Inhibits Solar-UV Induced Cutaneous Basal Cell Carcinoma Through Direct Inhibiting PBK/TOPK Protein Kinase.

Anticancer Agents Med Chem 2019 Mar 1. Epub 2019 Mar 1.

Department of Dermatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061. China.

Skin photoaging, skin inflammation and skin cancer are related with excessive exposure to solar ultraviolet light (solar-UV). PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a member of the serine/threonine protein kinase, which regulates the signaling cascades of p38 mitogen-activated protein kinase (p38 MAPK) and extracellular signal regulated kinase 1/2 (ERK1/2). PBK/TOPK plays a significant role in solar-UV-induced cutaneous basal cell carcinoma (cutaneous-BCC), and targeting PBK/TOPK can be supposed to treat and prevent cutaneous-BCC. Read More

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http://dx.doi.org/10.2174/1871520619666190301123131DOI Listing
March 2019
2 Reads
2.469 Impact Factor

Can optical coherence tomography improve the management of basal cell carcinoma?

Br J Dermatol 2019 Mar;180(3):448-449

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, U.S.A.

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http://dx.doi.org/10.1111/bjd.17522DOI Listing
March 2019
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Automated detection of nonmelanoma skin cancer using digital images: a systematic review.

BMC Med Imaging 2019 02 28;19(1):21. Epub 2019 Feb 28.

Department of Biomedical Data Science, Dartmouth College, Lebanon, NH, USA.

Background: Computer-aided diagnosis of skin lesions is a growing area of research, but its application to nonmelanoma skin cancer (NMSC) is relatively under-studied. The purpose of this review is to synthesize the research that has been conducted on automated detection of NMSC using digital images and to assess the quality of evidence for the diagnostic accuracy of these technologies.

Methods: Eight databases (PubMed, Google Scholar, Embase, IEEE Xplore, Web of Science, SpringerLink, ScienceDirect, and the ACM Digital Library) were searched to identify diagnostic studies of NMSC using image-based machine learning models. Read More

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http://dx.doi.org/10.1186/s12880-019-0307-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394090PMC
February 2019
2 Reads

Epidemiological evidence of carcinogenicity of sunbed use and of efficacy of preventive measures.

J Eur Acad Dermatol Venereol 2019 Mar;33 Suppl 2:57-62

International Prevention Research Institute, Lyon, France.

The International Agency for Research on Cancer classified, in July 2009, exposure to artificial tanning devices (sunbeds) as carcinogenic to humans. This classification was based on evidence from epidemiological and experimental animal studies. The present chapter will review these epidemiological evidences. Read More

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http://dx.doi.org/10.1111/jdv.15320DOI Listing
March 2019
1 Read