297,916 results match your criteria Basal Cell Carcinoma* Dermatology


Dopamine Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of Dopamine and Glutamate.

Cell Rep 2018 Dec;25(11):3148-3157.e3

Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

The balance of dopamine and acetylcholine in the dorsal striatum is critical for motor and learning functions. Midbrain dopamine cells and local cholinergic interneurons (ChIs) densely innervate the striatum and have strong reciprocal actions on each other. Although dopamine inputs regulate ChIs, the functional consequences of dopamine neuron activity across dorsal striatal regions is poorly understood. Read More

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December 2018

[Influence of HPV infection on cell cycle regulation in epithelial cell alterations of cervix uteri: Immunohistochemical and in situ hybridization observations].

Magy Onkol 2018 Dec 25;62(4):264-271. Epub 2018 Nov 25.

Daganatpatológiai Központ, Országos Onkológiai Intézet, Budapest, Hungary.

The HPV16 E6 DNA incorporation into the cervical epithelial cell genome was determined. In addition, using p16, p21 and p27 protein immunohistochemistry, we intended to present how the normal cell cycle machinery was disturbed in cervical epithelial cells. In CIN1 the epithelial cells are transformed into koilocytes, p16 is not expressed. Read More

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December 2018

A new microendemic species of the deep-water catshark genus Bythaelurus (Carcharhiniformes, Pentanchidae) from the northwestern Indian Ocean, with investigations of its feeding ecology, generic review and identification key.

PLoS One 2018 12;13(12):e0207887. Epub 2018 Dec 12.

Center of Natural History, University of Hamburg, Hamburg, Germany.

A new deep-water catshark, Bythaelurus stewarti, is described based on 121 examined specimens caught on the Error Seamount (Mount Error Guyot) in the northwestern Indian Ocean. The new species differs from all congeners in the restricted distribution, a higher spiral valve turn count and in the morphology of the dermal denticles. It is distinguished from its morphologically and geographically closest congener, B. Read More

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December 2018
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Integrative network-centric approach reveals signaling pathways associated with plant resistance and susceptibility to Pseudomonas syringae.

PLoS Biol 2018 Dec 12;16(12):e2005956. Epub 2018 Dec 12.

Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Mississippi State, Mississippi, United States of America.

Plant protein kinases form redundant signaling pathways to perceive microbial pathogens and activate immunity. Bacterial pathogens repress cellular immune responses by secreting effectors, some of which bind and inhibit multiple host kinases. To understand how broadly bacterial effectors may bind protein kinases and the function of these kinase interactors, we first tested kinase-effector (K-E) interactions using the Pseudomonas syringae pv. Read More

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December 2018

Esophageal IgG4: Clinical, Endoscopic, and Histologic Correlations in Eosinophilic Esophagitis.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Division of Pediatric Gastroenterology, Hepatology and Nutrition.

Objective: Recent studies show increased serum and esophageal IgG4 in patients with eosinophilic esophagitis (EoE), suggesting a possible IgG4-involved process. The role of IgG4 in pediatric EoE has not been extensively investigated. Our aim was to analyze IgG4 in esophageal tissue in children in parallel to that in adults with EoE. Read More

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December 2018
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Differential developmental changes in cortical representations of auditory-vocal stimuli in songbirds.

J Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.

University of Southern California, United States.

Procedural skill learning requires iterative comparisons between feedback of self-generated motor output and a goal sensorimotor pattern. In juvenile songbirds, neural representations of both self-generated behaviors (each bird's own immature song) and the goal motor pattern (each bird's adult tutor song) are essential for vocal learning, yet little is known about how these behaviorally relevant stimuli are encoded. We made extracellular recordings during song playback in anesthetized juvenile and adult zebra finches ( Taeniopygia guttata) in adjacent cortical regions RA (robust nucleus of the arcopallium), AId (dorsal intermediate arcopallium), and RA-cup, each of which is well-situated to integrate auditory-vocal information: RA is a motor cortical region that drives vocal output, AId is an adjoining cortical region whose projections converge with basal ganglia loops for song learning in the dorsal thalamus, and RA-cup surrounds RA and receives inputs from primary and secondary auditory cortex. Read More

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December 2018

The Dual Effect of the Brassinosteroid Pathway on Rice Black Streaked Dwarf Virus Infection by Modulating the Peroxidase-Mediated Oxidative Burst and Plant Defense.

Mol Plant Microbe Interact 2018 Dec 12. Epub 2018 Dec 12.

Fenghua Road 818,Ningbo, China , 315211 ;

The phytohormone brassinosteroids (BR) not only played key roles in regulating plant growth development but also involved in modulating plant defense system upon pathogens attack. Our previous study found that BR pathway was susceptible to Rice Blacked-Streaked Dwarf Virus (RBSDV), a devastating pathogen in rice. However, the detailed mechanism of BR-mediated susceptibility remains unclear. Read More

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December 2018

Cdc42 negatively regulates endocytosis during apical membrane maintenance in live animals.

Mol Biol Cell 2018 Dec 12:mbcE18100615. Epub 2018 Dec 12.

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr. Rm 2050B, Bethesda, MD, 20892 USA.

Lumen establishment and maintenance are fundamental for tubular organs physiological functions. Most of the studies investigating the mechanisms regulating this process have been carried out in cell cultures or in smaller organisms, whereas little has been done in mammalian model systems in vivo. Here we used the salivary glands of live mice to examine the role of the small GTPase Cdc42 in the regulation of the homeostasis of the intercellular canaliculi, a specialized apical domain of the acinar cells, where protein and fluid secretion occur. Read More

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December 2018

A two-photon fluorescent probe for basal formaldehyde imaging in zebrafish and visualization of mitochondrial damage induced by FA stress.

Analyst 2018 Dec 12. Epub 2018 Dec 12.

Beijing Key Laboratory of Photo-electronic/Electro-photonic Conversion Materials, Key Laboratory of Cluster Science of Ministry of Education, School of Chemistry and Chemical Engineering, Analytical and Testing Centre, Beijing Institute of Technology, Beijing 100081, P. R. China.

The detection of mitochondrial formaldehyde (FA) is of great significance because FA is generated through a one-carbon formaldehyde cycle in mitochondria, and abnormal elevations in FA levels can damage mitochondria by decreasing the mitochondrial membrane potential and inhibiting mitochondrial respiration. Herein, a mitochondria-targetable two-photon probe (Mito-FA-FP) has been well demonstrated. Mito-FA-FP is conjugated with hydrazine as the FA-reactive site and a pyridine derivate as the mitochondria-targetable moiety. Read More

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December 2018

Comparison and Correlation of Magnetic Resonance Imaging and Clinical Severity in Nonhuman Immunodeficiency Virus Patients with Cryptococcal Infection of Central Nervous System.

Chin Med J (Engl) 2018 Dec;131(24):2930-2937

Department of Radiology, Beijing Youan Hospital Affiliated to Capital Medical University, Beijing 100069, China.

Background: The incidence of cryptococcal meningitis among immunocompetent patients increases, especially in China and imaging plays an important role. The current study was to find the correlation between magnetic resonance imaging (MRI) manifestation and clinical severity in nonhuman immunodeficiency virus patients with cryptococcal infection of central nervous system (CNS).

Methods: A total of 65 patients with CNS cryptococcal infection from August 2014 to October 2016 were retrospectively included in this study. Read More

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December 2018

Nudel involvement in the high glucose-induced epithelial-mesenchymal transition of tubular epithelial cells.

Am J Physiol Renal Physiol 2018 Dec 12. Epub 2018 Dec 12.

pathology, Hebei medical university, China.

Nudel is a newly discovered factor related to cell migration. The tubular epithelial-mesenchymal transition (EMT) includes four steps: the loss of the adhesive properties of epithelial cells, the acquisition of a mesenchymal cell phenotype, the destruction of the tubular basal membrane and the migration into the renal interstitium. The purpose of this study was to investigate the role of Nudel in the high glucose-induced EMT of tubular epithelial cells. Read More

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December 2018

Unravelling reno-protective effects of SGLT2 inhibition in human proximal tubular cells.

Am J Physiol Renal Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Internal Medicine IV, Nephrology and Hypertension, Medical University Innsbruck, Austria.

Large clinical trials demonstrated that SGLT2 inhibitors (SGLT2i) slow the progression of kidney function decline in type 2 diabetes. As the underlying molecular mechanisms are largely unknown, we studied the effects of SGLT2i on gene expression in two human proximal tubular (PT) cell lines under normoglycemic conditions, utilizing two SGLT2i, namely empagliflocin and canagliflocin. Genome-wide expression analysis did not reveal substantial differences between these two SGLT2i. Read More

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December 2018

Variability of amino acid digestibility of lupin and pea grains in caecectomised laying hens.

Br Poult Sci 2018 Dec 12. Epub 2018 Dec 12.

a Institut für Nutztierwissenschaften , Universität Hohenheim , 70599 Stuttgart , Germany.

1 The objective of this study was to investigate the variations in amino acid (AA) digestibility of lupin and pea grains in caecectomised laying hens. The relationship between AA digestibility and chemical constituents of the grains was determined. 2. Read More

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December 2018
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Determination of Agonistically Acting Autoantibodies to the Adrenergic Beta-1 Receptor by Cellular Bioassay.

Methods Mol Biol 2019 ;1901:95-102

Berlin Cures GmbH, Berlin, Germany.

Agonistically acting autoantibodies directed against the adrenergic beta-1 receptor (beta1-AABs) are a pathogenic factor in diseases of the heart and circulatory system such as dilated cardiomyopathy. Here we describe the detection of such functionally active beta1-AABs from serum samples using spontaneously beating neonatal rat cardiomyocytes, which express the fully functional adrenergic beta-1 receptor coupled with the signal transduction pathway that induces chronotropy. With serum samples added (containing beta1-AABs), an increased positive chronotropic effect is caused that can be blocked by the subsequent addition of specific beta-blockers (abolishing this chronotropic response). Read More

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January 2019

Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence.

Dermatol Ther (Heidelb) 2018 Dec 11. Epub 2018 Dec 11.

Department of Plastic Surgery, Tan Tock Seng Hospital, Singapore, Republic of Singapore.

Basal cell carcinoma (BCC) is the most commonly diagnosed malignancy in humans, and as such it poses a significant healthcare burden. The majority of BCC cases are amenable to cure by surgical extirpation. However, until recently there have been no good treatment options for a significant minority of advanced BCC cases, including locally advanced BCC and metastatic BCC. Read More

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December 2018
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Effects of various abiotic factors on biomass growth and lipid yield of Chlorella minutissima for sustainable biodiesel production.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Bioenergy Research Laboratory, Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee (Saharanpur Campus), Saharanpur, Uttar Pradesh, 247001, India.

In this study, effects of different abiotic factors were studied on biomass and lipid yield of green microalga Chlorella minutissima (C. minutissima) Various concentrations of abiotic factors like nitrogen, phosphorus, glucose, iron, zinc, different values of pH, temperature, light intensity and different photoperiods were observed on the biomass growth and lipid yield of C. minutissima cultivated with modified CHU-13 medium. Read More

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December 2018

Squalene synthase cloning and functional identification in wintersweet plant (Chimonanthus zhejiangensis).

Bot Stud 2018 Dec 11;59(1):30. Epub 2018 Dec 11.

Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou, 310008, People's Republic of China.

Background: Three species of wintersweets: Chimonanthus salicifolius S. Y. Hu, Chimonanthus zhejiangensis M. Read More

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December 2018
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Increased Autophagy Levels Mediate Cisplatin Resistance in Cisplatin-Resistant Cells While Also Rendering Them Vulnerable to Autophagy Induction.

Biomed Res Int 2018 12;2018:1736738. Epub 2018 Nov 12.

Department of Gastroenterology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China.

Autophagy plays an important role in tumor development because of its capacity to maintain energy homeostasis by recycling damaged intracellular proteins and organelles, and increased autophagy levels are reported to mediate drug resistance in many cancers. However, whether high autophagy levels negatively impact tumor cell growth is unknown. Herein, we found that cisplatin (ddp)-resistant cells were more sensitive to glutamine (Gln) deprivation than ddp-sensitive cells, and they showed significant G1 arrest and increased apoptosis rates under Gln-deficient conditions. Read More

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November 2018

Olive mill wastewater phenolic concentrate as natural antioxidant against lipid-protein oxidative deterioration in chicken meat during storage.

Ital J Food Saf 2018 Sep 27;7(3):7342. Epub 2018 Sep 27.

Dipartimento di Medicina Veterinaria, Università degli Studi di Perugia.

Considering that many plant-derived substances show antioxidant and antimicrobial properties, natural antioxidant administered through feed in livestock animals could increase the shelf life of meat and meat products. The aim of this work was to study the effect of olive oil by-products on chicken meat lipid and protein oxidation and oxidative stability during storage. Two hundred and ninety-seven 22-day-old fast growing (Ross 308) female chicks were randomly assigned to three experimental grower-finisher diets: i) a basal control diet (CTR), ii) CTR diet supplemented with a low dosage (4. Read More

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September 2018

A retrospective analysis of the follicle-stimulating hormone starting dose in expected normal responders undergoing their first fertilization cycle: proposed dose versus empiric dose.

Clin Exp Reprod Med 2018 Dec 30;45(4):183-188. Epub 2018 Nov 30.

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Objective: The purpose of this retrospective study was to evaluate the appropriateness of various follicle-stimulating hormone (FSH) starting doses in expected normal responders based on the nomogram developed by La Marca et al.

Methods: A total of 117 first fertilization cycles performed from 2011 to 2017 were selected. All women were expected normal responders and used a recombinant FSH and flexible gonadotropin-releasing hormone antagonist protocol. Read More

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December 2018

Ancestrality and Mosaicism of Giant Viruses Supporting the Definition of the Fourth TRUC of Microbes.

Front Microbiol 2018 27;9:2668. Epub 2018 Nov 27.

Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM); Microbes, Evolution, Phylogeny and Infection (MEΦI); Institut Hospitalo-Universitaire (IHU) - Méditerranée Infection, Marseille, France.

Giant viruses of amoebae were discovered in 2003. Since then, their diversity has greatly expanded. They were suggested to form a fourth branch of life, collectively named 'TRUC' (for "Things Resisting Uncompleted Classifications") alongside , , and . Read More

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November 2018

Patient-controlled paravertebral analgesia for video-assisted thoracoscopic surgery lobectomy.

Local Reg Anesth 2018 22;11:115-121. Epub 2018 Nov 22.

Department of Anesthesia and Pain Medicine, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam,

Background: Paravertebral block has been proven to be an efficient method to provide post-thoracotomy pain management. This study aimed to compare patient-controlled paravertebral analgesia (PCPA) and intravenous patient-controlled analgesia (IVPCA) in terms of analgesic efficiency, respiratory function, and adverse effects after video-assisted thoracoscopic surgery (VATS) lobectomy.

Patients And Methods: The prospective randomized trial study was carried out on 60 patients who underwent VATS lobectomy (randomly allocated 30 patients in each group). Read More

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November 2018

Abscisic Acid Inhibits Rice Protein Phosphatase PP45 via H2O2 and Relieves Repression of the Ca2+/CaM-Dependent Protein Kinase DMI3.

Plant Cell 2018 Dec 11. Epub 2018 Dec 11.

College of Life Sciences, Nanjing Agricultural University CITY: Nanjing STATE: Jiangsu POSTAL_CODE: 210095 China [CN]

In plants, Ca2+/calmodulin-dependent protein kinase (CCaMK) is a positive regulator of abscisic acid (ABA) responses, including root growth, antioxidant defense and tolerance of both water stress and oxidative stress. However, the underlying molecular mechanisms are poorly understood. Here, we show a direct interaction between DMI3, a rice (Oryza sativa) CCaMK and PP45, a type 2C protein phosphatase in rice (PP2C). Read More

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December 2018

Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load.

Blood 2018 Dec 11. Epub 2018 Dec 11.

Lady Davis Institute for Medical Research, Jewish General Hospital and Department of Medicine, McGill University, Montreal, QC, Canada;

Transferrin receptor 1 (Tfr1) mediates uptake of circulating transferrin-bound iron to developing erythroid cells and other cell types. Its critical physiological function is highlighted by the embryonic lethal phenotype of Tfr1 knockout (Tfrc-/-) mice and the pathologies of several tissue-specific knockouts. We generated Tfrc mice bearing hepatocyte-specific ablation of Tfr1 to explore implications in hepatocellular and systemic iron homeostasis. Read More

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December 2018

Isolated cardiac sarcoidosis requiring open-chest myocardial biopsy for differentiation from malignant lymphoma.

J Cardiol Cases 2014 Jun 18;9(6):239-242. Epub 2014 Apr 18.

Cardiovascular, Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical University, Hokkaido, Japan.

A 68-year-old woman with a history of hypertension was admitted to our hospital because of dyspnea during physical exertion. Echocardiography demonstrated impaired left ventricular systolic function, and her ejection fraction was reduced to 30%. Coronary angiography did not show significant stenosis. Read More

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A case of ventricular septal rupture associated with major septal branch occlusion after percutaneous coronary intervention.

J Cardiol Cases 2014 Oct 17;10(4):140-143. Epub 2014 Jul 17.

Department of Cardiovascular Surgery, Shizuoka City Shizuoka Hospital, Shizuoka, Japan.

A 67-year-old man underwent elective percutaneous coronary intervention (PCI) of the left anterior descending artery. The major septal branch became occluded during coronary stenting. The patient developed dyspnea 19 days later. Read More

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October 2014

Left ventricular plasty improved cardiac function in a case of takotsubo cardiomyopathy with persistent aneurysm.

J Cardiol Cases 2013 May 15;7(5):e133-e136. Epub 2013 Feb 15.

Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan.

A 72-year-old woman was admitted to a local hospital due to repeated chest pain in December 2011. On admission, blood tests showed elevation of cardiac enzyme and B-type natriuretic peptide levels. Electrocardiography showed ST-segment elevation in almost all leads. Read More

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Manifest cardiac memory after biventricular pacing in a super-responder patient: Is memory the sign of a 'forgotten' electrical ventricular pattern?

J Cardiol Cases 2011 Dec 27;4(3):e129-e132. Epub 2011 Aug 27.

Division of Cardiovascular Diseases 2, Santa Chiara Hospital, University of Pisa, Via Roma 67, 56100 Pisa, Italy.

We present the case of a super-responder patient with a basal left bundle branch block, who underwent cardiac resynchronization therapy and showed, during biventricular pacing, typical electrocardiographic signs of cardiac memory. Read More

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December 2011

A patient with Wegener's granulomatosis in apparent remission presenting with complete atrioventricular block.

J Cardiol Cases 2011 Apr 20;3(2):e71-e74. Epub 2011 Feb 20.

Department of Cardiology, Royal Blackburn Hospital, Haslingden Road, Blackburn BB2 3HH, United Kingdom.

Wegener's granulomatosis is a systemic necrotizing granulomatous vasculitis of small- to medium-sized vessels typically affecting upper and lower airways, lungs, and kidneys. Cardiac involvement is less common and conducting tissue involvement is extremely rare. Cardiac manifestations are often not clinically apparent, but are associated with increased mortality. Read More

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April 2011
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Protective Mechanism of Adipose-Derived Stem Cells in Remodelling of the Skin Stem Cell Niche During Photoaging.

Cell Physiol Biochem 2018 11;51(5):2456-2471. Epub 2018 Dec 11.

Background/aims: Skin photoaging is primarily caused by the functional attrition of skin stem cells. The skin stem cell niche plays an important role in maintaining stem cell survival and behaviour. In our study, we hypothesized that UVB irradiation induces skin photoaging by changing skin stem cell niches and that transferred adipose-derived stem cells (ADSCs) can remodel the niches by affecting the BMP signalling pathway and transdifferentiating into skin stem cells. Read More

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December 2018
2 Reads

Prospective study of clinical, neurophysiological and urodynamic findings in multiple scleosis patients undergoing percutaneous transluminal venous angioplasty.

Clin Neurophysiol 2018 Nov 26;130(1):138-144. Epub 2018 Nov 26.

Department of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, University of Siena, Italy. Electronic address:

Objective: Verify whether Percutaneous Transluminal Angioplasty (PTA) may affect neural conduction properties in Multiple Sclerosis (MS) patients, thereby modifying patients' disability, with prospective neurophysiological, urodynamic, clinical and subjective well-being evaluations.

Methods: In 55 out of 72 consecutively screened MS patients, the following procedures were carried out before (T0), at 2-6 months (T1) and at 6-15 months (T2) after a diagnostic phlebography, eventually followed by the PTA intervention if chronic cerebrospinal venous insufficiency (CCSVI) was diagnosed: clinical/objective evaluation (Expanded Disability Status Scale, EDSS), ratings of subjective well-being, evaluation of urodynamic functions and multimodal EPs (visual, acoustic, upper and lower limbs somatosensory and motor evoked potentials).

Results: The number of dropouts was relatively high, and a complete set of neurophysiological and clinical data remained available for 37 patients (19 for urological investigations). Read More

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November 2018

Distal Thrombectomy for Acute Anterior Circulation Stroke with Chronic Large Vessel Occlusion.

World Neurosurg 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, Shandong, China. Electronic address:

Background: Endovascular therapy has been increasingly recommended for the treatment of acute ischemic stroke with large vessel occlusion of the anterior circulation. However, occlusions of the distal cerebral artery are not uncommon and may cause clinical deficits, especially when combined with ipsilateral chronic large vessel occlusion. Therefore, in this patient population, the recognition of chronic occlusion and recanalization of the distal occlusive artery might be of great value for flow compensation. Read More

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December 2018
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GAGA protein is required for multiple aspects of Drosophila oogenesis and female fertility.

Genesis 2018 Dec 10:e23269. Epub 2018 Dec 10.

Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Investigation of Drosophila oogenesis provides the opportunity to understand conservative genetic mechanisms underlying fertile female gamete development. In this work, we showed that the Drosophila DNA-binding protein GAGA factor (GAF) had a multifunctional role in oogenesis and it is involved in the regulation of this process genetic program. We studied the influence on Drosophila oogenesis of a number of mutations in the 5' region of the Trl gene that encodes GAF. Read More

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December 2018

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation.

Aging Cell 2018 Dec 10:e12845. Epub 2018 Dec 10.

Department of Cell Biology and Biophysics, Faculty of Biology, National & Kapodistrian University of Athens, Athens, Greece.

Metazoans viability depends on their ability to regulate metabolic processes and also to respond to harmful challenges by mounting anti-stress responses; these adaptations were fundamental forces during evolution. Central to anti-stress responses are a number of short-lived transcription factors that by functioning as stress sensors mobilize genomic responses aiming to eliminate stressors. We show here that increased expression of nuclear factor erythroid 2-related factor (Nrf2) in Drosophila activated cytoprotective modules and enhanced stress tolerance. Read More

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December 2018

Activation of immune receptor Rx1 triggers distinct immune-responses culminating in cell death after four hours.

Mol Plant Pathol 2018 Dec 8. Epub 2018 Dec 8.

University of Amsterdam, Molecular Plant Pathology, Amsterdam, Netherlands.

Intracellular NLR (nucleotide-binding leucine-rich repeat)-type immune receptors are a fundamental aspect of plant immune systems. As infection occurs at foci, activation of immune responses is typically non-uniform and non-synchronized, hampering the systematic dissection of their cellular effects and determining their phasing. We investigated the Potato NLR Rx1 using the CESSNA (Controlled Expression of effectors for Synchronized and Systemic NLR Activation) platform. Read More

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December 2018

Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas.

Background: Silver nanoparticles (AgNP) show efficacy in cancer cell lines. We present the first in-human outcome of AgNP in a cancer patient.

Methods: Homemade AgNP solution is manufactured using online instructions by a 78-year old male. Read More

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December 2018

50-Hz MF does not affect global DNA methylation of SH-SY5Y cells treated with the neurotoxin MPP.

Bioelectromagnetics 2018 Dec 7. Epub 2018 Dec 7.

Division of Health Protection Technologies, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Rome, Italy.

Exposure to extremely low frequency magnetic fields (ELF-MFs) has been associated with an increased risk of neurodegenerative disorders. The underlying mechanisms, however, are still debated. Since epigenetics play a key role in the neurodegenerative process, we investigated whether exposure to ELF-MF (50 Hz, 1 mT) might affect global DNA methylation of SH-SY5Y dopaminergic-like neuroblastoma cells. Read More

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December 2018

Does acclimation in cavitation resistance due to mechanical perturbation support the pit area or conduit reinforcement hypotheses in Phaseolus vulgaris?

Physiol Plant 2018 Dec 10. Epub 2018 Dec 10.

Department of Biology, Augustana University, Sioux Falls, SD 57197, USA.

Two Phaseolus vulgaris L. cultivars were exposed to reduced water and stem mechanical perturbation treatments (flexing) to determine if acclimation to these treatments induced hydraulic changes, altered cavitation resistance and changed stem mechanical properties. Additionally, this study sought to determine if changes in cavitation resistance would support the pit area or conduit reinforcement hypotheses. Read More

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December 2018

Edge-Functionalized Graphene Nanoplatelets as Metal-Free Electrocatalysts for Dye-Sensitized Solar Cells.

Adv Mater 2018 Dec 9:e1804440. Epub 2018 Dec 9.

Center for Dimension-Controllable Organic Frameworks, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST, Ulsan, 44919, Korea.

A scalable and low-cost production of graphene nanoplatelets (GnPs) is one of the most important challenges for their commercialization. A simple mechanochemical reaction has been developed and applied to prepare various edge-functionalized GnPs (EFGnPs). EFGnPs can be produced in a simple and ecofriendly manner by ball milling of graphite with target substances (X = nonmetals, halogens, semimetals, or metalloids). Read More

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December 2018
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The Fyn kinase inhibitor, AZD0530, suppresses mouse alcohol self-administration and seeking.

Addict Biol 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurology, University of California San Francisco, San Francisco, California.

Fyn is a member of the Src family of protein tyrosine kinases (PTKs) that plays an important role not only in normal synaptic functions but also in brain pathologies including alcohol use disorder. We previously reported that repeated cycles of binge drinking and withdrawal activate Fyn in the dorsomedial striatum (DMS) of rodents, and that Fyn signaling in the DMS contributes to rat alcohol intake and relapse. Here, we used AZD0530, a CNS penetrable inhibitor of Src PTKs developed for the treatment of Alzheimer disease and cancer and tested its efficacy to suppress alcohol-dependent molecular and behavioral effects. Read More

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December 2018

A chemogenetic approach for treating experimental Parkinson's disease.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: PD is a common neurodegenerative disease primarily affecting the cortico-basal ganglia loop.

Objective: To investigate whether chemogenetic-mediated neuromodulation of various nuclei and pathways can counterbalance basal ganglia network abnormalities and improve motor disability in experimental PD.

Methods: Experimental PD was induced by stereotactic injection of 6-OHDA to the medial forebrain bundle. Read More

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December 2018
3 Reads

Recurrence of periocular basal and squamous cell carcinoma after Mohs Micrographic Surgery: a retrospective cohort study.

Br J Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background: Despite the widespread use of Mohs Micrographic Surgery (MMS) for periocular basal and squamous cell carcinoma (together called keratinocyte carcinoma (KC)), follow-up data regarding recurrences are limited.

Objectives: To investigate the recurrence rate for periocular KCs after MMS and describe experience with interdisciplinary collaborations.

Methods: Patients with periocular KCs treated with MMS between 2006 and 2016 in a tertiary MMS referral hospital were included in this retrospective cohort study. Read More

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December 2018

Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation-deficient mice.

Neuropsychopharmacol Rep 2018 Dec 7. Epub 2018 Dec 7.

Section of Cellular Biochemistry, Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan.

Background: AMPA receptors predominantly mediate fast excitatory synaptic transmission in the mammalian brain. Post-translational protein S-palmitoylation of AMPA receptor GluA subunits at their C-termini reversibly controls the receptors trafficking to and from excitatory glutamatergic synapses. Excitatory inputs to neurons induce the expression of immediate early genes (IEGs), including Arc, with particular spatial patterns. Read More

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December 2018
1 Read

Cardiac metabolic modulation upon low-carbohydrate low-protein ketogenic diet in diabetic rats studied in vivo using hyperpolarized C pyruvate, butyrate, and acetoacetate probes.

Diabetes Obes Metab 2018 Dec 11. Epub 2018 Dec 11.

Functional Metabolism Group, Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, Singapore.

Aims: To investigate the effects of long-term low-carbohydrate low-protein ketogenic diet (KD) on cardiac metabolism and diabetic cardiomyopathy status in lean diabetic Goto-Kakizaki (GK) rats.

Materials And Methods: Diabetic GK rats were fed with KD for 62 weeks. Cardiac function and metabolism were assessed using magnetic resonance imaging and C magnetic resonance spectroscopy ( C-MRS), at rest and under dobutamine stress. Read More

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December 2018

Fire deficits have increased drought-sensitivity in dry conifer forests; fire frequency and tree-ring carbon isotope evidence from Central Oregon.

Glob Chang Biol 2018 Dec 9. Epub 2018 Dec 9.

Oregon State University, Forest Ecosystems and Society, 321 Richardson Hall, Corvallis, Oregon, United States, 97331-5752.

A century of fire suppression across the Western US has led to more crowded forests and increased competition for resources. Studies of forest thinning or stand conditions after mortality events have provided indirect evidence for how competition can promote drought stress and predispose forests to severe fire and/or bark beetle outbreaks. Here we demonstrate linkages between fire deficits and increasing drought stress through analyses of annually resolved tree-ring growth, fire scars, and carbon isotope discrimination (Δ C) across a dry mixed-conifer forest landscape. Read More

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December 2018

Multimodal magnetic resonance imaging investigation of basal forebrain damage and cognitive deficits in Parkinson's disease.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

Brain and Spine Institute - ICM, Center for NeuroImaging Research - CENIR, Paris, France.

Background: Cognitive deficits in Parkinson's disease (PD) may result from damage in the cortex as well as in the dopaminergic, noradrenergic, and cholinergic inputs to the cortex. Cholinergic inputs to the cortex mainly originate from the basal forebrain and are clustered in several regions, called Ch1 to Ch4, that project to the hippocampus (Ch1-2), the olfactory bulb (Ch3), and the cortex and amygdala (Ch4).

Objective: We investigated changes in basal forebrain and their role in cognitive deficits in PD. Read More

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December 2018

Association of brain natriuretic peptide and adrenomedullin plasma levels with left ventricular filling pressures in end-stage renal disease patients on hemodialysis.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7945-7951

1st Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Objective: Adrenomedullin (ADM) and brain natriuretic peptide (BNP) are known to be associated with elevated left ventricular filling pressures. However, little is known about this association in hemodialysis (HD) patients with preserved left ventricular ejection fraction (LVEF). Our objective was to evaluate the potential association between E/e' ratio and plasma levels of BNP and ADM in end-stage renal disease (ESRD) patients with preserved LVEF undergoing chronic hemodialysis. Read More

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November 2018

MiR-638 serves as a tumor suppressor by targeting HOXA9 in glioma.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7798-7806

Department of Neurosurgery, Shunde Hospital, Southern Medical University, The First People's Hospital of Shunde Foshan, Foshan, China.

Objective: MiR-638 is constantly downregulated and serves as a tumor suppressor in various cancers. Its role in gliomas remains unclear. This study is designed to investigate the clinical significance and the pathogenic role of miR-638 in human gliomas. Read More

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November 2018

[Speech and Language Disorders in the Elderly].

Authors:
Arno Olthoff

Laryngorhinootologie 2018 Dec 10;97(12):846-851. Epub 2018 Dec 10.

Phoniatrie und Pädaudiologie Göttingen, Klinik für Hals-, Nasen- und Ohrenheilkunde.

Cerebrovascular insults and neurodegenerative diseases are the main causes of acquired speech and language disorders. A massive increase in the prevalence of both is evident from the age of 65 years. By the age of 90 years, more than 10 % of the population would have experienced a stroke and 30 % would have suffered from neurodegenerative diseases. Read More

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December 2018

Bridging the Gap Between Self-Reported and Claims-Derived Adherence Measures for Basal Insulin Among Patients with Type 2 Diabetes Mellitus.

Adv Ther 2018 Dec 7. Epub 2018 Dec 7.

Janssen Research & Development, Titusville, NJ, USA.

Introduction: Complex or personalized insulin regimens challenge traditional adherence measures. Our objective was to develop an improved basal insulin (BI) adherence measure using both patient-reported and administrative claims data, resulting in a more complete measure.

Methods: Patients' self-reported BI utilization over the previous 12 months was linked with their claims data for the same period. Read More

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December 2018
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