6,414 results match your criteria Basal Cell Carcinoma* Dermatology

Vismodegib for Preservation of Visual Function in Patients with Advanced Periocular Basal Cell Carcinoma: The VISORB Trial.

Oncologist 2021 May 14. Epub 2021 May 14.

Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI.

Background: Basal cell carcinoma (BCC) is a common skin cancer often curable by excision; however, for patients with BCC around the eye, excision places visual organs and function at risk. Here we test the hypothesis that use of the hedgehog inhibitor vismodegib will improve vision-related outcomes in patients with orbital and extensive periocular BCC (opBCC).

Methods: In this open label, non-randomized phase 4 trial, we enrolled patients with globe- and lacrimal drainage system-threatening opBCC. Read More

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Optical Coherence Tomography of Peri-Ocular Skin Cancers: An Optical Biopsy.

Ocul Oncol Pathol 2021 Mar 2;7(2):149-158. Epub 2020 Dec 2.

The MUHC, McGill University Ocular Pathology and Translational Research Laboratory, McGill University, Montreal, Québec, Canada.

Introduction: Optical coherence tomography (OCT) imaging has been used as a diagnostic tool for retinal disease for several years, and OCT apparatuses are becoming increasingly powerful. However, OCT has yet to reach its full potential in ophthalmology clinics. Alike retinal layers, it has been shown that OCT is able to generate cross-sectional images of the skin and allows visualization of skin lesions in a histopathology-like manner. Read More

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Smoking and the risk of basal cell carcinoma: a systematic review and meta-analysis.

Int J Dermatol 2021 May 12. Epub 2021 May 12.

Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

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The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets.

Life Sci Alliance 2021 Jul 10;4(7). Epub 2021 May 10.

Division of Dermatology, Department of Medicine, McGill University, Montreal, Canada

Basal cell carcinoma (BCC) is the most common skin cancer and human malignancy. Although most BCCs are easily managed, some are aggressive locally, require Mohs micrographic surgery, or can even metastasize. In the latter, resistance to Sonic Hedgehog inhibitors may occur. Read More

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Itch and pain intensity in skin cancer: Why should dermatologic surgeons assess it?

Clin Dermatol 2021 Jan-Feb;39(1):119-122. Epub 2020 May 8.

Miami Itch Center Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine University of Miami, Miami, Florida, USA. Electronic address:

Nonmelanoma skin cancer is the most common type of cancer in the United States. Due to its rising incidence, better screening modalities assessing patient symptomatology are imperative. We reviewed the literature regarding pain and pruritus as presenting clinical manifestations of cutaneous malignancies and elucidate the clinical presentations among skin cancer subtypes. Read More

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Dermoscopic features of basal cell carcinoma in skin of color: A retrospective cross-sectional study from Puducherry, South India.

Indian J Dermatol Venereol Leprol 2021 Apr 23:1-7. Epub 2021 Apr 23.

Department of Pathology, AIIMS, Bhubaneswar, Odisha, India.

Background: Dermoscopy is useful in the diagnosis of basal cell carcinoma (BCC). However, most descriptions of the dermoscopic features of BCCs are in Caucasians (skin types I-III) and there is a paucity of data in dark-skinned Indian patients.

Aims: The aim of this study was to describe the various dermoscopic features of BCC in dark-skinned patients from South India and correlate these with the histopathologic subtypes. Read More

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Microdeletion of 9q22.3: A patient with minimal deletion size associated with a severe phenotype.

Am J Med Genet A 2021 May 7. Epub 2021 May 7.

Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia.

Basal cell nevus syndrome (also known as Gorlin Syndrome; MIM109400) is an autosomal dominant disorder characterized by recurrent pathological features such as basal cell carcinomas and odontogenic keratocysts as well as skeletal abnormalities. Most affected individuals have point mutations or small insertions or deletions within the PTCH1 gene on human chromosome 9, but there are some cases with more extensive deletion of the region, usually including the neighboring FANCC and/or ERCC6L2 genes. We report a 16-year-old patient with a deletion of approximately 400,000 bases which removes only PTCH1 and some non-coding RNA genes but leaves FANCC and ERCC6L2 intact. Read More

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Basal Cell Carcinoma Arising from an Epidermoid Cyst: A Histopathological Surprise.

Indian Dermatol Online J 2021 Mar-Apr;12(2):351-352. Epub 2020 Sep 28.

Pathology Consultancy Services, B-6, Sector 27, Noida, Uttar Pradesh, India.

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September 2020

Differential Diagnosis and Management on Seborrheic Keratosis in Elderly Patients.

Clin Cosmet Investig Dermatol 2021 28;14:395-406. Epub 2021 Apr 28.

Dermatology Unit, University of Campania, Naples, Italy.

Seborrheic keratoses are exceedingly common in the elderly and usually are easy to diagnose and do not require treatment. However, given their great variety of clinical presentation, they may give rise to false-positive cases, meaning that they may at times mimic melanoma, squamous cell carcinoma and basal cell carcinoma. On the other hand, melanoma may mimic seborrheic keratosis, leading to incorrect patient management. Read More

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Application of Cellular Resolution Full-Field Optical Coherence Tomography in vivo for the Diagnosis of Skin Tumours and Inflammatory Skin Diseases: A Pilot Study.

Dermatology 2021 May 4:1-11. Epub 2021 May 4.

Department of Dermatology, MacKay Memorial Hospital, Taipei, Taiwan.

Background: Optical coherence tomography (OCT) has been shown to provide non-invasive diagnosis of common skin neoplasms, especially basal cell carcinoma. OCT produces a cross-sectional view of the tissue, similar to a traditionally sectioned histopathological view, but the resolution of conventional OCT is low and thus limits clinical application.

Objectives: This study aimed to investigate the application ability of a full-field (FF)OCT system which was newly developed to scan the skin at the cellular level. Read More

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Dermoscopic features of neoplasms in skin of color: A review.

Int J Womens Dermatol 2021 Mar 19;7(2):145-151. Epub 2021 Jan 19.

Emory University School of Medicine, Department of dermatology, 1525 clifton Rd NE, Atlanta, GA 30322.

Background: Dermoscopy is undoubtedly a useful tool to improve diagnostic accuracy and minimize the number of unnecessary biopsies. However, much of the literature on dermoscopy focuses on findings in lighter-skin phototypes, leaving potential gaps of knowledge regarding its use in skin of color (SoC). As the clinical applications of dermoscopy continue to increase, understanding dermoscopic patterns in SoC is imperative. Read More

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Skin cancer in women of color: Epidemiology, pathogenesis and clinical manifestations.

Int J Womens Dermatol 2021 Mar 2;7(2):127-134. Epub 2021 Feb 2.

Callender Dermatology and Cosmetic Center, Glenn Dale, MD, United States.

Malignant melanoma and nonmelanoma skin cancers (NMSC), which include basal cell carcinoma and squamous cell carcinoma, account for 40% of all neoplasms in white patients, making these cancers the most common malignancy in the United States. Given the large number of NMSC cases in white patients, there is a correspondingly large body of literature addressing various aspects of epidemiology, pathogenesis, and treatment. The incidence of both malignant melanoma and NMSC is well established and remains significantly lower in patients with skin of color (SoC) when compared with white patients. Read More

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Skin Lesion Classification Using Additional Patient Information.

Biomed Res Int 2021 10;2021:6673852. Epub 2021 Apr 10.

Department of Dermatology, Shanghai Ninth Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, No. 639, Manufacturing Bureau Road, Huangpu District, Shanghai 200011, China.

In this paper, we describe our method for skin lesion classification. The goal is to classify skin lesions based on dermoscopic images to several diagnoses' classes presented in the HAM (Human Against Machine) dataset: melanoma (MEL), melanocytic nevus (NV), basal cell carcinoma (BCC), actinic keratosis (AK), benign keratosis (BKL), dermatofibroma (DF), and vascular lesion (VASC). We propose a simplified solution which has a better accuracy than previous methods, but only predicted on a single model that is practical for a real-world scenario. Read More

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A Deep Learning Based Framework for Diagnosing Multiple Skin Diseases in a Clinical Environment.

Front Med (Lausanne) 2021 16;8:626369. Epub 2021 Apr 16.

Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Numerous studies have attempted to apply artificial intelligence (AI) in the dermatological field, mainly on the classification and segmentation of various dermatoses. However, researches under real clinical settings are scarce. This study was aimed to construct a novel framework based on deep learning trained by a dataset that represented the real clinical environment in a tertiary class hospital in China, for better adaptation of the AI application in clinical practice among Asian patients. Read More

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A lobulated mass on the upper back with prominent vasculature: A giant basal cell carcinoma.

Dermatol Reports 2021 Mar 7;13(1):9046. Epub 2021 Apr 7.

Department of Dermatology, UT Southwestern Medical Center, Dallas, TX.

Basal cell carcinoma (BCC) is characterized by slow but locally invasive growth. Although there is low metastatic potential, if not treated early, these skin cancers can lead to significant morbidity and mortality. In this case report, we present a man with a neglected BCC that developed into what is termed a giant BCC or one that is greater than 5 cm. Read More

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Investigation of Genetic Mutations in High-risk and Low-risk Basal Cell Carcinoma in a Non-Caucasian Population by Whole Exome Sequencing.

Acta Derm Venereol 2021 Apr 30. Epub 2021 Apr 30.

Department of Dermatology, Changwon Fatima Hospital, 51394 Changwon, Korea.

This study analysed genomic mutations in basal cell carcinoma using whole exome sequencing of DNA specimens obtained from 20 Korean patients. Histological evaluation determined that 15 (75%) were low-risk basal cell carcinomas, and 5 (25%) were high-risk basal cell carcinomas. Seventy-five percent of the basal cell carcinomas harboured somatic mutations in hedge-hog pathway genes (PTCH1, 40% and SMO, 50%) and 45% harboured mutations in TP53. Read More

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Small Molecules in the Treatment of Squamous Cell Carcinomas: Focus on Indirubins.

Cancers (Basel) 2021 Apr 7;13(8). Epub 2021 Apr 7.

Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, Germany.

Skin cancers are the most common malignancies in the world. Among the most frequent skin cancer entities, squamous cell carcinoma (SCC) ranks second (~20%) after basal cell carcinoma (~77%). In early stages, a complete surgical removal of the affected tissue is carried out as standard therapy. Read More

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Approach to a Patient with Cutaneous Malignancy in the Time of COVID-19 Pandemic.

J Cutan Aesthet Surg 2020 Oct-Dec;13(4):349-352

Department of Plastic Reconstructive and Burns Surgery, All India Institute of Medical Sciences, New Delhi, India.

The world is facing an unprecedented crisis of COVID-19 pandemic. This disease has weakened the economy, paralyzed the healthcare system, and worn out the human resources. Patients with cutaneous malignancy or skin cancer comprise a substantial part of the patient population and they need appropriate management of the cancer as they face the risk of COVID-19. Read More

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Adhesion Molecules in Non-melanoma Skin Cancers: A Comprehensive Review.

In Vivo 2021 May-Jun;35(3):1327-1336. Epub 2021 Apr 28.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland

Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequently diagnosed cancers, generating significant medical and financial problems. Cutaneous carcinogenesis is a very complex process characterized by genetic and molecular alterations, and mediated by various proteins and pathways. Cell adhesion molecules (CAMs) are transmembrane proteins responsible for cell-to-cell and cell-to-extracellular matrix adhesion, engaged in all steps of tumor progression. Read More

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Histopathologic PD-L1 Tumor Expression and Prognostic Significance in Nonmelanoma Skin Cancers: A Systematic Review.

Am J Dermatopathol 2021 May;43(5):321-330

Fellow, Dermatopathology Section, Geisinger Medical Center, Danville, PA.

Abstract: PD-L1 and PD-1 inhibitors are being increasingly used to treat a variety of nonmelanoma skin cancers (NMSCs). This systematic review summarizes PD-L1 expression in NMSCs and determines its use for prognosis using targeted immunotherapy. A primary search of peer-reviewed English-language medical literature was conducted for studies on PD-L1 tumor expression in biopsied or excised NMSCs. Read More

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Misclassification of Aggressive Basal Cell Carcinoma Subtypes and Implications for Management.

Dermatol Surg 2021 May;47(5):593-598

Department of Dermatology, University of Nebraska Medical Center, Omaha, Nebraska.

Background: Management of basal cell carcinoma (BCC) varies by histopathologic subtype; however, biopsies may inadequately characterize them as nonaggressive, risking potential suboptimal treatment.

Objective: To characterize the rate of undetected aggressive BCC subtypes by size, location, and histopathology type.

Materials And Methods: Retrospective cohort study of 928 BCCs treated with Mohs Micrographic Surgery (MMS) at a tertiary academic institution from 2015 to 2017, comparing patient and tumor characteristics and histopathologic subtype on biopsy versus Mohs. Read More

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Topical Application of Glycerol Increases Penetration Depth of Optical Coherence Tomography in Diagnosis of Basal Cell Carcinoma.

Acta Derm Venereol 2021 04 27. Epub 2021 Apr 27.

Department of Dermatology, Maastricht University Medical Centre+, 6229HX Maastricht, The Netherlands. E-mail:

Optical coherence tomography is a non-invasive imaging technique that enables high-resolution in vivo imaging of skin. Although optical coherence tomography is promising for diagnosing basal cell carcinoma, its limited penetration depth may impede basal cell carcinoma subtyping. This study evaluated whether topical application of glycerol can increase penetration depth and improve the image quality and visibility of characteristic features of basal cell carcinoma. Read More

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Low-Dose Acitretin for Secondary Prevention of Keratinocyte Carcinomas in Solid-Organ Transplant Recipients.

Dermatology 2021 Apr 26:1-6. Epub 2021 Apr 26.

Division of Dermatology, Rabin Medical Center, Beilinson Hospital, Petah-Tiqva, Israel.

Background: Keratinocyte carcinomas, particularly squamous cell carcinoma (SCC), occur more frequently and aggressively in solid-organ transplant recipients (SOTRs) than in the general population. Systemic retinoids are effective in secondary prevention of keratinocyte carcinomas in this population, but their use is limited by adverse effects including a rebound effect in cases of treatment discontinuation.

Objective: Our aim was to determine whether low-dose acitretin is efficient in the secondary prevention of keratinocyte carcinomas in SOTRs. Read More

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Combination of targeted therapy and immune checkpoint blocker in a patient with xeroderma pigmentosum presenting an aggressive angiosarcoma and a recurrent non-resectable basal cell carcinoma.

Eur J Cancer 2021 Apr 23;150:130-132. Epub 2021 Apr 23.

Dermatology Unit, Gustave Roussy Cancer Campus, Villejuif, France; Inserm U981, Gustave Roussy Cancer Campus, Villejuif, France; University Paris-Saclay, Faculty of Medicine, Kremlin-Bicêtre, France. Electronic address:

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Desmoplastic Trichoepithelioma With Pseudocarcinomatous Hyperplasia: A Folliculosebaceous Neoplasm in Young Persons.

Am J Dermatopathol 2021 Apr 21. Epub 2021 Apr 21.

UCSF Dermatopathology and Oral Pathology Service, University of California San Francisco, San Francisco, CA; Departments of Pathology and Dermatology, University of California San Francisco, San Francisco, CA; Department of Dermatology, Yale University School of Medicine, New Haven, CT; and Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, CA.

Abstract: Pseudocarcinomatous desmoplastic trichoepithelioma (PDTE) features verrucous squamous epidermal hyperplasia with a jagged undersurface overlying cords of follicular germinative cells in a fibrotic stroma. To date, only 5 cases have been reported. We identified 7 new PDTEs from 2 institutions and reviewed their clinical manifestations and immunohistochemical profile. Read More

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Expression of Transient Receptor Potential Channel of Melastatin number 8 (TRPM8) in Non- Melanoma Skin Cancer: A Clinical and Immunohistochemical study.

J Immunoassay Immunochem 2021 Apr 25:1-13. Epub 2021 Apr 25.

Dermatology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt.

Transient Receptor Potential Channel of Melastatin number 8 (TRPM8) is abnormally expressed in many cancers as lung, however little is known about TRPM8 expression in non-melanoma skin cancer (NMSC) including cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). This work aimed to study TRPM8 expression in NMSC. It included 100 skin biopsies (50 normal skin as control group, 15 BCC and 35 SCC). Read More

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Hidden Basal Cell Carcinoma in the Intergluteal Crease.

Cutis 2021 Feb;107(2):95-96

Ms. Schwartzberg is from New York Institute of Technology College of Osteopathic Medicine, Old Westbury. Dr. Arora is from the Ronald O. Perelman Department of Dermatology, New York University Langone Health, New York, and Borealis Dermatology, Garden City, New York.

Basal cell carcinoma (BCC) is the most common cancer and often is found in sun-exposed areas, particularly the head and neck. However, BCCs also can arise in unexpected locations. Intergluteal crease BCC is a rare finding and often can be overlooked. Read More

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February 2021

Basal cell carcinoma arising in surgical drain insertion sites.

Ital J Dermatol Venerol 2021 Apr 23. Epub 2021 Apr 23.

Division of Dermatology, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy -

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