7,031 results match your criteria Basal Cell Carcinoma* Dermatology

Real-time, In Vivo Skin Cancer Triage by Laser-Induced Plasma Spectroscopy Combined with Deep Learning-based Diagnostic Algorithm.

J Am Acad Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Human-Computer Interaction, Hanyang University, Seoul, South Korea.

Background: Although various skin cancer detection devices have been proposed, most of them are not used owing to their insufficient diagnostic accuracies. Laser-induced plasma spectroscopy (LIPS) can noninvasively extract biochemical information of skin lesions using an ultrashort pulsed laser.

Objective: To investigate the diagnostic accuracy and safety of a real-time noninvasive in vivo skin cancer diagnostics utilizing non-discrete molecular LIPS combined with a deep neural network (DNN)-based diagnostic algorithm. Read More

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Role of Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis.

J Pers Med 2022 Jun 16;12(6). Epub 2022 Jun 16.

State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.

Psoriasis and skin tumors (such as basal cell carcinoma, squamous cell carcinoma, and melanoma) are chronic diseases that endanger physical and mental health, and yet the causes are largely unknown and treatment options limited. The development of targeted drugs requires a better understanding of the exact pathogenesis of these diseases, and Yes-associated protein (YAP), a member of the Hippo signaling pathway, is believed to play an important role. Psoriasis and skin tumors are characterized by excessive cell proliferation, abnormal differentiation, vasodilation, and proliferation. Read More

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A Conservative Combined Laser Cryoimmunotherapy Treatment vs. Surgical Excision for Basal Cell Carcinoma.

J Clin Med 2022 Jun 15;11(12). Epub 2022 Jun 15.

Department of Dermatology I, Colentina Hospital, "Carol Davila" University of Medicine and Pharmacy, 19-21 Stefan Cel Mare Road, 020125 Bucharest, Romania.

Surgical excision is the standard treatment for basal cell carcinoma (BCC), but it can be challenging in elderly patients and patients with comorbidities. The non-surgical guidelines procedures are usually regarded as monotherapy options. This quasi-experimental, non-randomized, comparative effectiveness study aims to evaluate the efficacy of a combined, conservative, non-surgical BCC treatment, and compare it to standard surgical excision. Read More

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Identifying Candidates for Immunotherapy among Patients with Non-Melanoma Skin Cancer: A Review of the Potential Predictors of Response.

J Clin Med 2022 Jun 11;11(12). Epub 2022 Jun 11.

Dermatology Clinic, Maggiore Hospital, University of Trieste, 34125 Trieste, Italy.

Background: Non-melanoma skin cancer (NMSC) stands as an umbrella term for common cutaneous malignancies, including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), together with rarer cutaneous cancers, such as Merkel cell carcinoma (MCC) and other forms of adnexal cancers. The majority of NMSCs can be successfully treated with surgery or radiotherapy, but advanced and metastatic stages may require systemic approaches such as immunotherapy with immune checkpoint inhibitors (ICIs).

Summary: Since immunotherapy is not effective in all patients and can potentially lead to severe adverse effects, an important clinical question is how to properly identify those who could be suitable candidates for this therapeutic choice. Read More

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Secondary Malignant Tumors Arising in Nevus Sebaceus: Two Case Reports.

Diagnostics (Basel) 2022 Jun 13;12(6). Epub 2022 Jun 13.

Department of Dermatology, International University of Health and Welfare, Narita 286-8520, Chiba, Japan.

Nevus sebaceus is a benign tumor that is present at birth and is often seen on the scalp or face. Secondary malignant tumors sometimes occur in nevus sebaceus in adulthood. Herein, we present two malignant tumors arose from nevus sebaceus. Read More

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Non-Melanoma Skin Cancer Clearance after Medical Treatment Detected with Noninvasive Skin Imaging: A Systematic Review and Meta-Analysis.

Cancers (Basel) 2022 Jun 8;14(12). Epub 2022 Jun 8.

Dermatologic Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.

Background/objectives: Non-melanoma skin cancer (NMSC) treated with nonsurgical therapies can be monitored with noninvasive skin imaging. The precision of dermoscopy, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) in detecting clearance is unclear. We aim to report the proportion of persisting tumors identified with noninvasive technologies available in the literature. Read More

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Hedgehog pathway inhibitor real-world treatment patterns in patients with basal cell carcinoma: a claims-based analysis.

Future Oncol 2022 Jun 23. Epub 2022 Jun 23.

Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.

To examine real-world treatment patterns for Hedgehog pathway inhibitors (HHIs) for the treatment of advanced basal cell carcinoma. HHI initiators between January 2013 and June 2019 were identified from IBM MarketScan claims data. Time to treatment discontinuation and reinitiation were estimated using Kaplan-Meier methods using a 60-day grace period. Read More

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Recurrent cutaneous basal cell carcinoma after surgical excision: A retrospective clinicopathological study.

Ann Med Surg (Lond) 2022 Jun 26;78:103877. Epub 2022 May 26.

Mansoura Dermatology, Venerology and Leprology Hospital, Mansoura, Egypt.

Background: Recurrence of basal cell carcinoma (BCC) after complete surgical excision is rarely reported. Risk factors for this negative outcome are not well-studied. We present the clinical and histological features of recurrent BCCs in our institution. Read More

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Basal Cell Carcinoma: A Narrative Review on Contemporary Diagnosis and Management.

Oncol Ther 2022 Jun 21. Epub 2022 Jun 21.

Department of Histopathology, University Hospital Dorset NHS Foundation Trust, Bournemouth, UK.

Basal cell carcinoma (BCC) is the most common, accounting for 80-90% of skin cancers. It arises from the basal layer of the epidermis and its appendages. A complex interplay of environmental, phenotypic and genetic variables leads to the development of BCC. Read More

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Tuberous sclerosis and risk of skin cancer: a nationwide cohort study in the United States.

J Am Acad Dermatol 2022 Jun 18. Epub 2022 Jun 18.

Department of Dermatology, Stanford University School of Medicine, Stanford, California. Electronic address:

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Melanoma survivors are at increased risk for second primary keratinocyte carcinoma.

Int J Dermatol 2022 Jun 21. Epub 2022 Jun 21.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Background: Recent large cohorts have reported that melanoma survivors are at risk of developing second keratinocyte carcinoma (KC). However, the detailed proportion and risk are still unknown. We aimed to comprehensively analyze the risk of developing keratinocyte carcinoma after primary melanoma. Read More

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The correlation between tumor thickness and aggressive histopathological pattern in Basal cell carcinoma.

J Cosmet Dermatol 2022 Jun 28;21(6):2577-2580. Epub 2021 Sep 28.

Department of Pathology, School of Medicine, Hacettepe University, Ankara, Turkey.

Background: The significance of tumor thickness is not clear in the prognosis of basal cell carcinoma. We aimed to identify the relationship between the tumor thickness and aggressive histopathological growth pattern in BCC.

Methods: We retrospectively reviewed 85 primary BCCs of 82 patients. Read More

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Surgery combined with photodynamic therapy vs. surgery alone for the treatment of non-melanoma skin cancer and actinic keratosis: a retrospective cohort study.

Dermatol Ther 2022 Jun 18:e15652. Epub 2022 Jun 18.

Department of Pathology, Panzhihua Central Hospital, Panzhihua, Sichuan Province, China.

Background: Photodynamic therapy (PDT) is an effective treatment for some non-melanoma skin cancers (NMSC) and actinic keratosis.

Objectives: To compare recurrence-free survival (RFS) rates between surgery alone and surgery with postoperative PDT in patients with NMSC in China.

Methods & Materials: This retrospective cohort study included patients with pathologically confirmed NMSC or actinic keratosis treated by surgical excision with/without PDT. Read More

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Basal cell carcinoma of the scalp shows distinct features from the face in Asians.

Sci Rep 2022 Jun 17;12(1):10183. Epub 2022 Jun 17.

Department of Dermatology, Seoul National University Bundang Hospital, 82 Gumi-Ro 173 Beon-Gil, Seongnam, 13620, Gyeonggi, Korea.

Basal cell carcinoma (BCC) affecting different sites has been reported to have different clinicopathological features. In previous studies, the scalp was commonly classified to the head and neck region. However, the scalp has distinct characteristics from those of other parts of the skin. Read More

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Single-cell analysis of human basal cell carcinoma reveals novel regulators of tumor growth and the tumor microenvironment.

Sci Adv 2022 06 10;8(23):eabm7981. Epub 2022 Jun 10.

Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.

How basal cell carcinoma (BCC) interacts with its tumor microenvironment to promote growth is unclear. We use singe-cell RNA sequencing to define the human BCC ecosystem and discriminate between normal and malignant epithelial cells. We identify spatial biomarkers of tumors and their surrounding stroma that reinforce the heterogeneity of each tissue type. Read More

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Keystone Flap Reconstruction After Large Mohs Micrographic Surgery Defect of Basal Cell Carcinoma on the Upper Arm: A Case Report.

Cureus 2022 Jun 7;14(6):e25709. Epub 2022 Jun 7.

Department of Dermatology, Case Western Reserve University, School of Medicine and MetroHealth System, Cleveland, USA.

Large defects after Mohs micrographic surgery present a reconstructive challenge. The keystone design perforator island flap has proven to be simple and effective in the repair of large skin defects after cancer removal. We present a case of such a defect on the upper arm that was successfully reconstructed with the keystone flap. Read More

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In vitro 5-Fluorouracil resistance produces enhanced photodynamic therapy damage in SCC and tumor resistance in BCC.

J Photochem Photobiol B 2022 May 29;233:112483. Epub 2022 May 29.

Department of Biology, Faculty of Sciences, Autónoma University of Madrid (UAM), Madrid 28049, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid 28034, Spain. Electronic address:

Non-melanoma skin cancer (NMSC) is the most common malignancy worldwide, with rising incidence in the recent years. It includes basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Several non-invasive therapies have been developed for its treatment such as topical 5-Fluorouracil (5FU) and photodynamic therapy (PDT), among others. Read More

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Experience with sonidegib in patients with advanced basal cell carcinoma: case reports.

Drugs Context 2022 23;11. Epub 2022 May 23.

Dermatology Department, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.

Sonidegib is a Hedgehog signalling pathway inhibitor approved for use in patients with advanced basal cell carcinoma (BCC) not eligible for surgery or radiotherapy. This report describes clinical experience with sonidegib in two patients with locally advanced BCC (one with a tumour adjacent to the right eye and the other with a tumour associated with the left ear) and in one patient with Gorlin syndrome. Two of the patients had recurrent and intractable tumours. Read More

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Neurotropic Cutaneous Malignancies: Case Report on Keratinocyte Derived Malignancies of the Head and Neck With Perineural Invasion.

Front Oncol 2022 23;12:846278. Epub 2022 May 23.

Moores Cancer Center, University of California, San Diego, La Jolla, CA, United States.

Background: The recent addition of immunotherapy as a treatment modality to surgery and radiation has vastly improved disease control for patients with keratinocyte-derived carcinomas (KCs) that are incurable with local therapies alone. With the advent of immune checkpoint inhibitors (ICPis) in non-melanoma skin cancers comes diagnostic and therapeutic challenges when considering treatment strategies for patients presenting with clinical perineural invasion (cPNI) of locally advanced KC of the head and neck.

Objectives: We report four cases that convey the diagnostic and therapeutic complexity of managing patients with neuropathic symptoms from cutaneous neurotropic carcinomas of the head and neck. Read More

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An updated report on the incidence and epidemiological trends of keratinocyte cancers in the United Kingdom 2013-2018.

Skin Health Dis 2021 Dec 18;1(4):e61. Epub 2021 Aug 18.

National Cancer Registration and Analysis Service London UK.

Introduction: The most common cancers in the UK are keratinocyte cancers (KCs): the combined term for basal cell carcinomas (BCCs) and cutaneous squamous cell carcinomas (cSCCs). Registration of KC is challenging due to high numbers and multiplicity of tumours per person.

Methods: We provide an updated report on the descriptive epidemiology of trends in KC incidence for the resident populations of UK countries (England, Northern Ireland, Scotland and Wales) using population-based cancer registry and pathology report data, 2013-18. Read More

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December 2021

Ex vivo histological correlation using dermoscopy.

JAAD Int 2022 Sep 28;8:56-57. Epub 2022 May 28.

Dermatology Department, Complejo Asistencial Universitario de León, León, Spain.

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September 2022

Dermoscopy as an Aid in the Differentiation of Recurrent Eyelid Basal Cell Carcinoma Versus apocrine Hidrocystoma.

Dermatol Pract Concept 2022 May 1;12(2):e2022090. Epub 2022 Apr 1.

Department of Dermatology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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Features of Skin Cancer in Black Individuals: A Single-Institution Retrospective Cohort Study.

Dermatol Pract Concept 2022 May 1;12(2):e2022075. Epub 2022 Apr 1.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Introduction: Minimal knowledge exists regarding skin cancers in Black individuals, which may adversely affect patient care.

Objectives: To describe clinical features and risk factors of skin cancers in Black individuals.

Methods: Retrospective study of Black individuals diagnosed with skin cancer between January 2000 and January 2020 at our institution. Read More

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Observational study of a series of basal cell carcinomas: Evaluation of location as a risk factor for recurrence.

J Stomatol Oral Maxillofac Surg 2022 May 26. Epub 2022 May 26.

Department of Dermatology, Dijon Bourgogne University Hospital Center, 14 rue Paul Gaffarel, Dijon 21000, France.

Basal cell carcinoma (BCC) is locally aggressive and its prognosis depends on the risk of recurrence. The initial location of the tumor is a key criterion for calculating the risk of recurrence. The aim of this study was to evaluate the sites that appear to be most at risk of recurrence of BCC. Read More

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Mohs micrographic surgery revisited: A multidisciplinary, collaborative approach for the treatment of aggressive and recurrent basal cell carcinoma on the head and neck.

J Plast Reconstr Aesthet Surg 2022 Apr 25. Epub 2022 Apr 25.

Dermatology and Venereology Division, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Mohs micrographic surgery is the preferred surgical option for high-risk basal cell carcinomas. In our institution, the method is exclusively used for the treatment of aggressive and recurrent facial tumours selected via multidisciplinary team meetings and consistently managed using a multidisciplinary approach. The aim of this retrospective patient-record study was to examine the outcomes for basal cell carcinomas managed with Mohs micrographic surgery and to present our experience from multidisciplinary team meetings and interdisciplinary collaborations. Read More

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Long-Noncoding RNA ANCR Activates the Hedgehog Signaling Pathway to Promote Basal Cell Carcinoma Progression by Binding to PTCH.

Clin Cosmet Investig Dermatol 2022 25;15:955-965. Epub 2022 May 25.

Department of Dermatology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People's Republic of China.

Purpose: The long non-coding RNA (lncRNA) anti-differentiation noncoding RNA (ANCR) is closely related to the occurrence and development of various malignancies. However, its expression and potential role in basal cell carcinoma (BCC) have not been established. In this study, we characterized the effects of ANCR in BCC and its underlying mechanism. Read More

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Use of Thiazide Diuretics and Risk of All Types of Skin Cancers: An Updated Systematic Review and Meta-Analysis.

Cancers (Basel) 2022 May 23;14(10). Epub 2022 May 23.

Department of Medicine, Division of Nephrology, University of Ottawa, Ottawa, ON K1H 8L6, Canada.

Background: The use of thiazide diuretics is associated with skin cancer risk; however, whether this applies to all skin cancer types is unclear.

Methods: In this meta-analysis, we searched multiple electronic databases and gray literature up to 10 April 2022, with no language restrictions, to identify relevant randomized controlled trials (RCTs) and non-randomized studies (cohort, case-control) that investigated the association between thiazide diuretics and skin cancer. The primary outcomes of interest were malignant melanoma and non-melanoma skin cancer (basal cell carcinoma [BCC], squamous cell carcinoma [SCC]). Read More

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Eight Years of Real-Life Experience with Smoothened Inhibitors in a Swiss Tertiary Skin Referral Center.

Cancers (Basel) 2022 May 19;14(10). Epub 2022 May 19.

Department of Dermatology, University Hospital of Zurich, 8091 Zurich, Switzerland.

Background: The hedgehog inhibitors vismodegib and sonidegib are approved for the treatment of advanced basal cell carcinoma. This study reports the experiences with these therapies in a tertiary skin referral center in daily practice.

Methods: A retrospective, observational, single-center study analyzing medical records of patients with aBCC treated with a smoothened (SMO) inhibitor outside a clinical trial for at least one month between 2013 and 2021. Read More

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Artificial intelligence and machine learning algorithms for early detection of skin cancer in community and primary care settings: a systematic review.

Lancet Digit Health 2022 06;4(6):e466-e476

Department of Public Health & Primary Care, University of Cambridge, Cambridge, UK; Centre for Cancer Research and Department of General Practice, University of Melbourne, Melbourne, VIC, Australia; Wolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.

Skin cancers occur commonly worldwide. The prognosis and disease burden are highly dependent on the cancer type and disease stage at diagnosis. We systematically reviewed studies on artificial intelligence and machine learning (AI/ML) algorithms that aim to facilitate the early diagnosis of skin cancers, focusing on their application in primary and community care settings. Read More

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