5,914 results match your criteria Basal Cell Carcinoma* Dermatology


Giant Basal Cell Carcinoma including focal Squamous Cell Carcinoma of the Buttock: A Rare Case.

Dermatol Ther 2020 May 23. Epub 2020 May 23.

Medical Faculty, Johannes Kepler University Linz, Altenberger Straße 69, Linz, Austria.

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http://dx.doi.org/10.1111/dth.13674DOI Listing

The Role of Anti-PD-1/PD-L1 in the Treatment of Skin Cancer.

BioDrugs 2020 May 23. Epub 2020 May 23.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Skin cancers remain the most common group of cancers globally, and the incidence continues to rise. Although localized skin cancers tend to have excellent outcomes following surgical excisions, the less common cases that become surgically unresectable or metastatic have been associated with poor prognosis and suboptimal treatment responses to cytotoxic chemotherapy. Development of monoclonal antibodies to programmed cell death-1 receptor and its ligand (PD-1/PD-L1) have transformed the management of metastatic melanoma, squamous cell carcinoma, and Merkel cell carcinoma. Read More

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http://dx.doi.org/10.1007/s40259-020-00428-9DOI Listing

Genetic and environmental factors underlying keratinocyte carcinoma risk.

JCI Insight 2020 May 21;5(10). Epub 2020 May 21.

Kaiser Permanente Northern California, Division of Research, Oakland, California, USA.

Recent large-scale GWAS and large epidemiologic studies have accelerated the discovery of genes and environmental factors that contribute to the risk of keratinocyte carcinoma (KC), which includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This Review summarizes the genomic regions associated with SCC and BCC risk, examines the genetic overlap between SCC and BCC, and discusses biological pathways involved in SCC and BCC development. Next, we review environmental factors that are associated with KC risk, including those that are shared between SCC and BCC as well as others that associated with only one type of KC. Read More

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http://dx.doi.org/10.1172/jci.insight.134783DOI Listing

Chronic Venous Insufficiency As A Predisposing Factor For Basal Cell Carcinoma On Legs.

Ann Vasc Surg 2020 May 15. Epub 2020 May 15.

Medical School, Unicamp, Departments of Pathology. Electronic address:

Background: The main risk factor associated with basal cell carcinoma (BCC) is believed to be exposure to ultraviolet radiation (UVR). In the case of lower limb BCC, the frequency is higher in women, possibly because of greater leg UVR exposure. Chronic venous insufficiency (CVI), also more common in women, may have some association with leg BCC. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.04.053DOI Listing

The effectiveness of vismodegib in patients with advanced periocular basal cell carcinoma: a case series of 13 patients.

J Dermatolog Treat 2020 May 18:1-5. Epub 2020 May 18.

Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.

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http://dx.doi.org/10.1080/09546634.2020.1771262DOI Listing

Successful Treatment of Topical Imiquimod-resistant Basal Cell Carcinoma by Electronic X-ray Brachytherapy.

Dermatol Ther 2020 May 17:e13609. Epub 2020 May 17.

Department of Dermatology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1111/dth.13609DOI Listing

Advanced basal cell carcinoma treated with vismodegib: impact on the lives of patients and their families.

Clin Exp Dermatol 2020 May 16. Epub 2020 May 16.

Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Locally advanced basal cell carcinoma (laBCC) has always represented an uncommon, difficult to treat form of skin cancer until the hedgehog inhibitor (HHI) vismodegib was approved. Approximately 80% of laBCCs occur in the head and neck region causing disfiguring skin changes that impact on patients' quality of life. Because the lives of patients with advanced BCCs are severely disrupted, it would be expected that the quality of life of family members involved in caregiving, would also be affected. Read More

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http://dx.doi.org/10.1111/ced.14287DOI Listing

Dermoscopic features and differential diagnosis of sebaceous carcinoma.

J Dermatol 2020 May 16. Epub 2020 May 16.

Department of Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan.

Sebaceous carcinoma is a rare malignant skin neoplasm arising from sebaceous glands. Its clinical diagnosis is difficult and reports of dermoscopic findings have been limited. This study aims to analyze its dermoscopic features and differential diagnosis in dermoscopic examination. Read More

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http://dx.doi.org/10.1111/1346-8138.15384DOI Listing

A story of a pimple: Newly diagnosed chronic lymphocytic leukemia in a basal cell carcinoma biopsy.

J Cutan Pathol 2020 May 16. Epub 2020 May 16.

Department of Pathology, University of Virginia, Charlottesville, Virginia.

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http://dx.doi.org/10.1111/cup.13745DOI Listing

Current Research in Melanoma and Aggressive Nonmelanoma Skin Cancer.

Facial Plast Surg 2020 Apr 15;36(2):200-210. Epub 2020 May 15.

Department of Dermatology, New York University Langone Health, New York, New York.

There have been several significant advances in cancer treatment in the last decade that are applicable to the treatment of melanoma and advanced nonmelanoma skin cancers. Among these are the development of immune checkpoint inhibitors targeting the programmed death protein-1 (PD-1)/programmed death legand-1 (PDL-1) axis, as well as targeted inhibitors of the BRAF/MEK signaling cascade in melanoma, and the hedgehog signaling pathway in basal cell carcinoma (BCC). These immune-based and targeted therapies have dramatically changed the treatment options for locally advanced and metastatic melanoma, Merkel's cell carcinoma, cutaneous squamous cell carcinoma (cSCC), and BCC. Read More

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http://dx.doi.org/10.1055/s-0040-1709118DOI Listing

Mohs Surgery versus Standard Local Excision for Basal Cell Carcinoma, Squamous Cell Carcinoma, and Melanoma Skin Cancer.

Facial Plast Surg 2020 Apr 15;36(2):133-140. Epub 2020 May 15.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan.

Basal cell carcinoma, squamous cell carcinoma, and melanoma represent the three most common skin cancers that occur on the face. The most common surgical treatments for facial skin cancers are Mohs' surgery and standard local excision. The effective utilization of either of these techniques is based on tumor and patient risk stratification incorporating known risk factors for occult invasion and local recurrence, combined with patient comorbidities, expectations, and desires. Read More

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http://dx.doi.org/10.1055/s-0040-1709142DOI Listing

An Analysis of Biopsies for Suspected Skin Cancer at a Tertiary Care Dermatology Clinic in the Western Cape Province of South Africa.

J Skin Cancer 2020 27;2020:9061532. Epub 2020 Jan 27.

Division of Dermatology, Department of Medicine, Tygerberg Academic Hospital, Stellenbosch University, Cape Town, South Africa.

Background: Skin cancer is a growing health concern worldwide. It is the most common malignancy in South Africa and places a large burden on the public healthcare sector. There is a paucity of published scientific data on skin cancer in South Africa. Read More

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http://dx.doi.org/10.1155/2020/9061532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204328PMC
January 2020

Coding and noncoding somatic mutations in candidate genes in basal cell carcinoma.

Sci Rep 2020 May 14;10(1):8005. Epub 2020 May 14.

Division of Functional Genome Analysis, German Cancer Research Center, Heidelberg, Germany.

Basal cell carcinoma (BCC) represents the most commonly diagnosed human cancer among persons of European ancestry with etiology mainly attributed to sun-exposure. In this study we investigated mutations in coding and flanking regions of PTCH1 and TP53 and noncoding alterations in the TERT and DPH3 promoters in 191 BCC tumors. In addition, we measured CpG methylation within the TERT hypermethylated oncological region (THOR) and transcription levels of the reverse transcriptase subunit. Read More

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http://dx.doi.org/10.1038/s41598-020-65057-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224188PMC

The American Brachytherapy society consensus statement for skin brachytherapy.

Brachytherapy 2020 May 11. Epub 2020 May 11.

Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.

Purpose: Keratinocyte carcinoma (KC, previously nonmelanoma skin cancer) represents the most common cancer worldwide. While surgical treatment is commonly utilized, various radiation therapy techniques are available including external beam and brachytherapy. As such, the American Brachytherapy Society has created an updated consensus statement regarding the use of brachytherapy in the treatment of KCs. Read More

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http://dx.doi.org/10.1016/j.brachy.2020.04.004DOI Listing

A Monocentric, Retrospective Analysis of 61 Patients with Generalized Granuloma Annulare.

Dermatology 2020 May 13:1-6. Epub 2020 May 13.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland,

Background: Granuloma annulare is a chronic noninfectious granulomatous skin condition with variable clinical presentations. Generalized granuloma annulare, defined as widespread disease with >10 skin lesions, accounts for 15% of all cases. Numerous associated diseases have been controversially discussed, most importantly diabetes mellitus, dyslipidemia, thyroid disease, malignancy and systemic infections. Read More

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http://dx.doi.org/10.1159/000507247DOI Listing

Incidental Skin Cancer Detection in a Hospital Department: A Prospective Study.

Actas Dermosifiliogr 2020 May 5. Epub 2020 May 5.

Servicio de Dermatología. Hospital Universitario Son Llàtzer (HUSLL). Institut d'Investigació Sanitària de les Illes Balears (IdISBa), Crta. de Manacor km 4, 07198 Palma, España.

Background And Objectives: Skin cancer is a common cause for referral to dermatology, but it may also be an incidental finding during examination of patients referred for other reasons. The objective of the study was to compare the characteristics of skin cancer lesions (squamous skin carcinoma, basal cell carcinoma, melanoma) diagnosed at a dermatology department over 1 year between patients referred for suspected skin cancer and those referred for another reason but in whom skin cancer was detected as an incidental finding. Pearson's χ test was used to compare different study variables between the 2 groups. Read More

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http://dx.doi.org/10.1016/j.ad.2020.04.006DOI Listing

Sebaceous Carcinoma And Basal Cell Carcinoma Arising Within Nevus Sebaceous On the Face-A Rare Entity with Dermatoscopic Findings.

Dermatol Ther 2020 May 13:e13576. Epub 2020 May 13.

Dermatology Department, Ankara University School of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1111/dth.13576DOI Listing

Sclerodermiform basal cell carcinomas versus other histotypes: analysis of specific demographic, clinical and dermatoscopic features.

J Eur Acad Dermatol Venereol 2020 May 13. Epub 2020 May 13.

Dermatology Clinic, Maggiore Hospital, University of Trieste, Trieste, Italy.

Background: Among the various types of basal cell carcinoma, the sclerodermiform variant has a high risk of recurrence and local invasiveness. A systematic description of the dermatoscopic features associated with specific body localization is lacking.

Objectives: To describe the clinical and dermoscopic features of sclerodermiform BCC according to localization in the body confronting with superficial and nodular types. Read More

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http://dx.doi.org/10.1111/jdv.16597DOI Listing

Voriconazole and the Risk of Keratinocyte Carcinomas Among Lung Transplant Recipients in the United States.

JAMA Dermatol 2020 May 13. Epub 2020 May 13.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.

Importance: The antifungal medication voriconazole is used to prevent and treat aspergillosis, a major cause of mortality among recipients of lung transplants (hereinafter referred to as lung recipients). Small studies suggest that voriconazole increases risk of cutaneous squamous cell carcinoma (SCC).

Objective: To examine associations of voriconazole and other antifungal medications with risk of keratinocyte carcinomas (SCC and cutaneous basal cell carcinoma [BCC]) in lung recipients. Read More

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http://dx.doi.org/10.1001/jamadermatol.2020.1141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221851PMC

Why it's hard to see a dermatologist for a skin exam: the patient perspective.

Arch Dermatol Res 2020 May 12. Epub 2020 May 12.

University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA.

Background: In-office skin exams are recommended at least annually for patients who are diagnosed with a basal cell carcinoma or squamous cell carcinoma, but it is unknown what proportion of these patients are receiving skin exams. There are a multitude of reasons why patients have difficulty getting skin exams.

Aim: To assess the proportion of patients at our institution who received a skin exam in the 12 months following removal of a basal cell carcinoma or squamous cell carcinoma by Mohs micrographic surgery and to assess the barriers to care that patients faced in receiving a skin exam. Read More

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http://dx.doi.org/10.1007/s00403-020-02080-3DOI Listing

It's time for Mohs: Micrographic surgery for the treatment of high-risk basal cell carcinomas of the head and neck regions.

Dermatol Ther 2020 May 11:e13474. Epub 2020 May 11.

Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Basal cell carcinoma (BCC) is the most common variety of non-melanoma skin cancer and its incidence is increasing worldwide. The centrofacial sites (area H) are considered a high-risk factor for BCC local recurrence. Mohs micrographic surgery (MMS) is a technique that allows intraoperative microscopic control of the surgical margins and is a good treatment option when tissue conservation is required for esthetic or functional reasons or for high-risk lesions. Read More

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http://dx.doi.org/10.1111/dth.13474DOI Listing

Fitzpatrick Phototype Disparities in Identification of Cutaneous Malignancies by Google Reverse Image.

J Am Acad Dermatol 2020 May 7. Epub 2020 May 7.

Department of Dermatology, Stanford University School of Medicine, Stanford, California. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.05.005DOI Listing

Drug holiday approach for Vismodegib treatment in patients with nevoid basal cell carcinoma syndrome: 3 cases from real clinical practice.

Dermatol Ther 2020 May 8:e13540. Epub 2020 May 8.

Dermatology department, Consorcio Hospital General Universitario de Valencia.

Sonic hedgehog pathway inhibitor Vismodegib is the first systemic treatment to be approved for metastatic or locally advanced basal cell carcinoma (BCC) non-subsidiary of surgical treatment, and appears to be a promising treatment option for patients with nevoid basal cell carcinoma syndrome (NBCCS). In these patients, where repeated or prolonged treatment may be necessary, the psychological exhaustion caused by the chronicity of less severe adverse effects appears as the main limiting factor in the persistence of the drug in the long term and in the willingness of patients to take the drug again after its suspension. We report our experience with three cases where a drug holiday approach was effective in decreasing the intensity of adverse effects or improving the patient's subjective tolerance to the drug while maintaining clinical response. Read More

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http://dx.doi.org/10.1111/dth.13540DOI Listing

Preauricular banner transposition flap in the reconstruction of an ear conchal defect after basal cell carcinoma surgery.

Dermatol Ther 2020 May 8:e13543. Epub 2020 May 8.

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Dresden, Germany.

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http://dx.doi.org/10.1111/dth.13543DOI Listing

The use of cisplatin electrochemotherapy in non-melanoma skin cancers: A single-center study.

Dermatol Ther 2020 May 9:e13547. Epub 2020 May 9.

Department of Surgery, University of Perugia, Italy.

Background: Electrochemotherapy (ECT) is a well-known non-conventional skin cancer ablative method that was shown to be safe and effective for treating both locoregional disease spreading and disseminated cutaneous and subcutaneous lesions from different type of cancer. The most common medications used are bleomycin and cisplatin. In the last years many studies were performed on ECT, lead it to be a valid therapeutic option in many international guidelines. Read More

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http://dx.doi.org/10.1111/dth.13547DOI Listing

Clinical Management of Locally Advanced Basal-Cell Carcinomas and Future Therapeutic Directions.

Dermatol Ther (Heidelb) 2020 May 7. Epub 2020 May 7.

Clinic for Dermatology and Allergy, University Hospital Bonn, 53127, Bonn, Germany.

Treatment of choice for nodular basal-cell carcinomas (BCCs) is complete excision, implying that small lesions are of minor concern. Metastasis is very rare (< 1%). However, locally advanced basal-cell carcinomas (laBCCs), which are ineligible for surgery or radiation, are a therapeutic challenge. Read More

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http://dx.doi.org/10.1007/s13555-020-00382-yDOI Listing

Identification of Potential Biomarkers Associated with Basal Cell Carcinoma.

Biomed Res Int 2020 17;2020:2073690. Epub 2020 Apr 17.

Department of Dermatology & STD, The Third Central Hospital of Tianjin, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin Institute of Hepatobiliary Disease, Tianjin 300170, China.

Purpose: This work is aimed at identifying several molecular markers correlated with the diagnosis and development of basal cell carcinoma (BCC).

Methods: The available microarray datasets for BCC were obtained from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) were identified between BCC and healthy controls. Afterward, the functional enrichment analysis and protein-protein interaction (PPI) network analysis of these screened DEGs were performed. Read More

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http://dx.doi.org/10.1155/2020/2073690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189327PMC

Density of Langerhans Cells in Nonmelanoma Skin Cancers: A Systematic Review.

Mediators Inflamm 2020 19;2020:8745863. Epub 2020 Apr 19.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.

Langerhans cells (LCs) are bone marrow-derived dendritic cells (DCs) that represent 2-3% of the entire cell population of the human skin, known to have an ability to present antigens to T lymphocytes. Moreover, there is evidence that LCs are probably capable of inducing the local cytotoxic type T-cell-mediated response against the tumour-associated antigens. In the past two decades, a dramatic increase has been noted in the incidence of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Read More

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http://dx.doi.org/10.1155/2020/8745863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187722PMC

Cohort analysis of safety and efficacy of vismodegib in Italian patients from the Phase II, multicenter STEVIE study.

Future Oncol 2020 Jun 6;16(16):1091-1100. Epub 2020 May 6.

Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" Naples, Italy.

To assess safety and efficacy of vismodegib in the Italian cohort from the SafeTy Events in VIsmodEgib study. Data from Italian patients with locally advanced basal cell carcinoma (laBCC) or metastatic BCC were analyzed. Among 182 Italian patients, adverse events occurred with similar incidence to the overall population. Read More

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http://dx.doi.org/10.2217/fon-2019-0664DOI Listing

Re. Cosmetic tattooing and early onset basal cell carcinoma: a population-based case control study from New Hampshire.

Epidemiology 2020 Apr 22. Epub 2020 Apr 22.

Department of Health Security, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1097/EDE.0000000000001206DOI Listing

Online Skin Cancer Education for Organ Transplant Recipients: A Missed Opportunity.

J Am Acad Dermatol 2020 Apr 29. Epub 2020 Apr 29.

Department of Dermatology, Tufts University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1016/j.jaad.2020.04.131DOI Listing

Cumulative risk of skin cancer in patients with Li-Fraumeni syndrome.

Fam Cancer 2020 Apr 30. Epub 2020 Apr 30.

Department of Dermatology, Netherlands Cancer Institute, Plesmanlaan 12, 1066, CX, Amsterdam, The Netherlands.

Li-Fraumeni syndrome (LFS) is an inherited cancer syndrome, characterized by an early onset of various types of cancers. LFS is associated with a germline mutation in the TP53 gene. The risk of developing skin cancer in patients with LFS is unknown. Read More

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http://dx.doi.org/10.1007/s10689-020-00178-1DOI Listing

Screening and Intervention for Skin Cancer in the Galapagos.

Ann Plast Surg 2020 Apr 28. Epub 2020 Apr 28.

Division of Plastic and Reconstructive Surgery at Stony Brook University Hospital.

Objective: This study aimed to assess the general dermatological needs and correlation of tentative skin cancer screening diagnoses with histopathological confirmation in the highly sun-exposed locals of the Galapagos Islands.

Methods: An institutional review board-approved prospective study was performed at Blanca's House, a nonprofit surgical volunteer organization, free clinics in the Galapagos. After consent, a 40-item modified SPOTme-inspired questionnaire was completed. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002345DOI Listing

Peritumoral Clefting and Expression of MMP-2 and MMP-9 in Basal Cell Carcinoma of the Skin.

In Vivo 2020 May-Jun;34(3):1271-1275

School of Medicine, University of Zagreb, Zagreb, Croatia

Background/aim: Peritumoral clefting is one of the main histologic features of basal cell carcinoma of the skin (BCC). The aim of the study was to analyze the expression of MMP-2 and MMP-9 both in cells of basal cell carcinoma and in the adjacent stroma and to correlate the findings of immunohistochemical analysis with the presence of peritumoral clefting.

Patients And Methods: The study was made on archival material comprising 48 cases of BCC. Read More

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http://dx.doi.org/10.21873/invivo.11901DOI Listing

Emerging noninvasive treatments of nonmelanoma skin cancers.

Cutis 2020 03;105(3):138-142;E5

Department of Dermatology, Mount Sinai Medical Center, New York, New York; the Department of Dermatology, SUNY Downstate Medical Center, Brooklyn; and the Department of Dermatology, New York Harbor Healthcare System, Brooklyn, USA.

Nonmelanoma skin cancer (NMSC) is the most common malignancy worldwide, and the incidence continues to increase. Originally, treatment options for NMSCs largely relied on destructive and surgical methods. Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) commonly are treated with cryosurgery, electrodesiccation and curettage, or more definitive surgical options. Read More

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March 2020
0.594 Impact Factor

Development of a patient decision aid for the management of superficial basal cell carcinoma (BCC) in adults with a limited life expectancy.

BMC Med Inform Decis Mak 2020 Apr 29;20(1):81. Epub 2020 Apr 29.

Department of Dermatology, Stanford University, CCSR Building Room 4235, 269 Campus Drive, Stanford, USA.

Background: Basal cell carcinoma (BCC) is a slow-growing, rarely lethal skin cancer that affects people 65 years or older. A range of treatment options exist for BCC, but there is little evidence available to guide patients and providers in selecting the best treatment options.

Objectives: This study outlines the development of a patient decision aid (PDA) for low-risk BCC that can be used by patients and providers to assist in shared decision-making. Read More

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http://dx.doi.org/10.1186/s12911-020-1081-8DOI Listing

Update in the Management of Basal Cell Carcinoma.

Acta Derm Venereol 2020 Apr 28. Epub 2020 Apr 28.

Department of Dermatology, Hôpital Saint Louis, FR-75010 Paris, France.

Basal cell carcinomas are the most frequent skin cancers in the fair-skinned adult population over 50 years of age. Their incidence is increasing throughout the world. Ultraviolet (UV) exposure is the major carcinogenic factor. Read More

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http://dx.doi.org/10.2340/00015555-3495DOI Listing

Dermoscopy-guided Mohs micrographic surgery in post-laser basal cell carcinomas: Is dermoscopy helpful for demarcation of the surgical margin?

J Dermatolog Treat 2020 Apr 29:1-12. Epub 2020 Apr 29.

Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea.

Mohs micrographic surgery (MMS) in cases where the tumor margin is poorly defined to the naked eye can lead to the need to take an increased number of Mohs stages. To evaluate the usefulness of dermoscopy in determining MMS surgical margins of BCCs with a history of ablative laser treatment. Patients were randomly allocated to naked eye (n = 69) or dermoscopy (n = 64) groups by the surgical margin detection method. Read More

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http://dx.doi.org/10.1080/09546634.2020.1762839DOI Listing

Differentiating Basal Cell Carcinoma from Intradermal Nevi along the Eyelid Margin with Dermoscopy: A Case Series.

J Am Acad Dermatol 2020 Apr 21. Epub 2020 Apr 21.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL; Sylvester Comprehensive Cancer Center, Miami, FL. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.04.059DOI Listing

Lentivirus‑mediated CD44s expression increases human basal cell carcinoma cell resistance against vismodegib.

Oncol Rep 2020 May 6;43(5):1650-1658. Epub 2020 Mar 6.

Department of Dermatology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710014, P.R. China.

High drug resistance, which is usually mediated by drug resistance‑associated genes, is a characteristic of human tumours. CD44s, an ATP‑binding cassette multidrug resistance transporter, is expressed in a variety of human cancers. In the present study, the effect of CD44s expression was investigated on BCC resistance against vismodegib. Read More

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http://dx.doi.org/10.3892/or.2020.7534DOI Listing

Surgery versus combined treatment with Curettage and Imiquimod for Nodular basal cell carcinoma (SCIN): 1-year results of a non-inferiority, randomized controlled trial.

J Am Acad Dermatol 2020 Apr 19. Epub 2020 Apr 19.

Department of Epidemiology, Maastricht University, Maastricht, The Netherlands; Department of Dermatology, Maastricht University Medical Centre, Maastricht, The Netherlands; GROW Research Institute for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Purpose: Nodular basal cell carcinoma (nBCC) is mostly treated with surgical excision. Interest in minimally invasive treatment of these low-risk tumors is increasing. We assessed the effectiveness of nBCC treatment with curettage and imiquimod cream compared to surgical excision. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.053DOI Listing

Global evidence on occupational sun exposure and keratinocyte cancers: a systematic review.

Br J Dermatol 2020 Apr 22. Epub 2020 Apr 22.

Department Dermatology, Environmental Medicine, Health Theory, University of Osnabrück, Osnabrück, Germany.

Individual studies have suggested that the association between occupational exposure to solar ultraviolet radiation (UVR) and the development of keratinocyte cancers (KC) may only be valid in populations of European ancestry living in certain geographic regions. Comparative global data are scarce and so this review aimed to summarize current evidence on the association between occupational exposure to solar UVR and the development of KC, with a specific focus on geographic location and skin colour. Ovid Medline, PubMed, EMBASE, and Web of Science were searched for potentially relevant records. Read More

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http://dx.doi.org/10.1111/bjd.19152DOI Listing

SHARPIN regulates cell proliferation of cutaneous basal cell carcinoma via inactivation of the transcriptional factors GLI2 and c‑JUN.

Mol Med Rep 2020 Apr 7;21(4):1799-1808. Epub 2020 Feb 7.

Department of Dermatology, Cosmetology and Venereology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518101, P.R. China.

SHANK‑associated RH domain‑interacting protein (SHARPIN) is a component of the linear ubiquitin chain assembly complex that can enhance the NF‑κB and JNK signaling pathways, acting as a tumor‑associated protein in a variety of cancer types. The present study investigated the role of SHARPIN in cutaneous basal cell carcinoma (BCC). Human BCC (n=26) and normal skin (n=5) tissues, and BCC (TE354. Read More

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http://dx.doi.org/10.3892/mmr.2020.10981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057814PMC

Inhibition of basal cell carcinoma cells by cold atmospheric plasma‑activated solution and differential gene expression analysis.

Int J Oncol 2020 May 6;56(5):1262-1273. Epub 2020 Mar 6.

Teaching and Research Section of Nuclear Medicine, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

Basal cell carcinoma is a common skin tumor. Cold atmospheric plasma (CAP) has attracted increasing attention for its antitumor effects. The aim of the present study was to investigate the effects and related mechanisms of two CAP‑activated solutions on the TE354T basal cell carcinoma and HaCat keratinocyte cell lines. Read More

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http://dx.doi.org/10.3892/ijo.2020.5009DOI Listing

Galectin-3 regulates UVB-induced inflammation in skin.

J Dermatol Sci 2020 Apr 8. Epub 2020 Apr 8.

Department of Dermatology, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; Mackay Junior College of Medicine, Nursing, and Management, New Taipei City, Taiwan. Electronic address:

Background: Galectin-3 is widely expressed in many immunocytes and epithelial cells including skin keratinocytes. Galectin-3 can regulate immunological or inflammatory processes and plays a proinflammatory role in some disease models. Galectin-3 has a role in disorders related to ultraviolet (UV) photodamage such as apoptosis, skin squamous cell carcinoma and basal cell carcinoma. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2020.03.007DOI Listing

Lesion compression during light activation may improve efficacy of photodynamic treatment of basal cell carcinoma: preliminary results and rationale.

J Eur Acad Dermatol Venereol 2020 Apr 20. Epub 2020 Apr 20.

Photobiology Unit, Ninewells Hospital and Medical School, Dundee, UK.

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http://dx.doi.org/10.1111/jdv.16503DOI Listing

Global incidence of incomplete surgical excision in adult patients with non-melanoma skin cancer: study protocol for a systematic review and meta-analysis of observational studies.

Syst Rev 2020 Apr 17;9(1):83. Epub 2020 Apr 17.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Oxford, OX3 7LD, UK.

Background: Non-melanoma skin cancer, which includes basal cell carcinoma and cutaneous squamous cell carcinoma, is the commonest malignancy worldwide. The mainstay of treatment is surgical excision. Despite this being an exceptionally common procedure, it is not known what the accepted standard is for incomplete excision. Read More

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http://dx.doi.org/10.1186/s13643-020-01350-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164252PMC

BerEP4 positivity in Merkel cell carcinoma: a potential diagnosis pitfall.

J Eur Acad Dermatol Venereol 2020 Apr 17. Epub 2020 Apr 17.

Department of Pathology, Université de Tours, CHU de Tours, avenue de la République, 37170, Chambray-les-tours, France.

Merkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin with a 5-year overall survival estimated at 40% . In 2008, Merkel cell Polyomavirus (MCPyV) integration was identified as the primary oncogenic event of about 80% of MCC cases. Under microscopic examination, MCC appears as a proliferation of basaloid tumor cells invading the dermis and subcutaneous tissues. Read More

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http://dx.doi.org/10.1111/jdv.16482DOI Listing