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Dermatol Surg 2021 Jul;47(7):1000-1001

Department of Dermatology, Nottingham NHS Treatment Centre, Nottingham University Hospitals, Nottingham, United Kingdom.

Kathmandu Univ Med J (KUMJ) 2020 Oct.-Dec.;18(72):434-436

Department of ENT, Indira Gandhi Medical College and Research Institute, Pondicherry, India.

Basal Cell Adenoma (BCA) known as monomorphic adenoma is a rare type of benign epithelial salivary neoplasm that mostly occurs in the parotid gland. Clinically BCA appears as a firm, mobile, slow-growing mass and is usually diagnosed during the histopathological examination of the resected surgical specimen. Histological differential diagnosis ranges from benign to malignant neoplasms such as pleomorphic adenoma, basal cell adenocarcinoma, adenoid cystic carcinoma and basaloid squamous cell carcinoma. Read More

Ann Transl Med 2021 May;9(10):915

Australian Centre for Oral Oncology Research & Education, Nedlands, WA, Australia.

Head and neck squamous cell carcinomas (HNSCC) arising from the oral cavity, pharynx, and larynx constitute the 6 most common human cancer. Human papillomavirus (HPV)-positive tumours are distinct from HPV-negative counterparts, with HPV status affording clear clinical utility, prognostic benefit and better treatment outcomes. In contrast to their HPV-positive counterparts, HPV-negative tumours are characterized by high mutational load and chromosomal aberrations, with varying copy number alteration (CNA) profiles. Read More

BMJ Case Rep 2021 Jun 23;14(6). Epub 2021 Jun 23.

Department of Pediatrics, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA.

Paediatric cardiac tumours are rare, often benign and carry associations with genetic conditions. Cardiac fibromas are mainly composed of fibroblast and connective tissue . They can lead to symptoms due to obstruction of blood flow or arrythmias. Read More

Rev Assoc Med Bras (1992) 2021 Jan;67(1):77-82

Hospital Universitário Professor Edgard Santos, Departamento de Dermatologia - Salvador (BA), Brasil.

Objective: Oculocutaneous albinism describes a group of pigmentary disorders that lead to skin sensitivity and predisposition to skin malignances.

Aims: To analyze clinical and epidemiological data in oculocutaneous albinism patients and to determine the prevalence of malignant skin lesions, assessing possible risk factors for skin cancer.

Methods: Cross-sectional study evaluating epidemiological data, habits of sun exposure and sun protection, and clinical examination of albino patients followed in a reference dermatology outpatient clinic in Brasil. Read More

Australas J Dermatol 2021 Jun 23. Epub 2021 Jun 23.

Skin Specialist Centre, Auckland, New Zealand.

Itraconazole is as an anti-fungal agent with the ability to inhibit the Hedgehog signalling pathway, which makes it a candidate drug that can be repurposed for the treatment of basal cell carcinomas (BCCs). We present a case of metastatic BCC, treated with oral itraconazole 100 mg twice daily, that resulted in sustained partial regression of metastatic pulmonary nodules. A systematic review on the clinical outcomes of BCCs treated with itraconazole highlights that current evidence for its clinical application remains limited and that this is the first case report where itraconazole monotherapy has achieved favourable response in metastatic BCC. Read More

Clin Exp Dermatol 2021 Jun 22. Epub 2021 Jun 22.

Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy.

Basal cell carcinoma (BCC) is the most common skin malignancy in humans. Most of the cases can be cured through complete surgical excision as recommended by international guidelines. However, a minority of BCCs progress to a locally advanced (laBCC) or metastatic form and in these late stages, surgery is not indicated as it is not effective. Read More

Am J Clin Pathol 2021 Jun 22. Epub 2021 Jun 22.

Department of Urology, Erasmus MC, Cancer Institute Rotterdam,  The Netherlands.

Objectives: To determine the potential impact of the presence of secondary variant histology on the gene expression profiles of muscle-invasive bladder cancer (MIBC) tumors.

Methods: For six tumors, revised samples were collected from urothelial and secondary variant components (cohort A). The commercial cohort (cohort B) consisted of the anonymized gene expression profiles of 173 patients with MIBC. Read More

Future Oncol 2021 Jun 22. Epub 2021 Jun 22.

Department of Dermatology, University of Texas McGovern Medical School at Houston, Houston, TX 77030, USA.

Although surgical therapy continues to be the gold standard for the treatment of basal cell carcinoma given high cure rates and the ability to histologically confirm tumor clearance, there are a number of nonsurgical treatment options that may be considered based on individual tumor characteristics, functional and cosmetic considerations, patient comorbidities and patient preference. Topical 5-fluorouracil 5% cream and imiquimod 5% cream have been US FDA-approved for the treatment of superficial basal cell carcinoma. Additionally, a number of new and emerging topical agents and techniques have been described for the treatment of basal cell carcinoma and will be reviewed herein. Read More

J Dermatolog Treat 2021 Jun 22:1-17. Epub 2021 Jun 22.

Dermatology & Plastic Surgery Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Background: Artificial intelligence (AI) image recognition models have been relatively successful in diagnosing cutaneous manifestations in individuals with light skin tone. However, when these models are tested on the same cutaneous manifestations in individuals with darker or brown skin tone, the performance of the model drops due to a paucity of such images available for model training.

Objective: The objective of this study was to improve the performance of AI models in recognizing cutaneous diseases in individuals with darker skin tone. Read More

J Am Acad Dermatol 2021 Jun 18. Epub 2021 Jun 18.

Department of Dermatology, Mayo Clinic, Scottsdale, AZ. Electronic address:

Dermatol Ther 2021 Jun 21:e15036. Epub 2021 Jun 21.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

ANZ J Surg 2021 Jun 21. Epub 2021 Jun 21.

College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.

Background: Non-melanoma skin cancers (NMSC) are the most common skin cancers worldwide with research establishing that ultraviolet (UV) radiation influences occurrence. However, recent studies about NMSC tumour frequencies suggested high NMSC predilections in low UV-exposed skin regions.

Methods: The 'Human Surface Anatomy Labeling System' was used to define 100 skin regions to map NMSC locations excised at Flinders Medical Centre (FMC) between 1 January 2012 and 31 December 2017. Read More

Dermatol Surg 2021 Jun 14. Epub 2021 Jun 14.

Nottingham University Hospitals NHS Trust Sheffield Teaching Hospitals NHS Foundation Trust.

Eur Ann Otorhinolaryngol Head Neck Dis 2021 Jun 17. Epub 2021 Jun 17.

Stockport NHS Foundation Trust, Stockport SK2 7JE, United Kingdom.

Biomed Pharmacother 2021 Jun 15;141:111809. Epub 2021 Jun 15.

Centre for Medical Biotechnology, Maharshi Dayanand University, Rohtak, Haryana, India. Electronic address:

Oral mucocutaneous cancers (OMCs) are cancers that affect both the oral mucosa and perioral cutaneous structures. Common OMCs are squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and malignant melanoma (MM). Anatomical similarities and conventions which categorizes these lesions blur the magnitude of OMCs in diverse populations. Read More

Am J Dermatopathol 2021 Jul;43(7):477-484

Chief, Department of Dermatology, Hyogo Cancer Center, Akashi, Japan.

Abstract: Lipomatous metaplasia has been rarely reported in both neoplastic and inflammatory dermatological disorders. Most neoplastic cases show the lipomatous change within the tumor silhouette, but band-like lipomatous metaplasia in the dermis under tumors has not been well-described. The aim of this study was to reveal the characteristics and relationship of intradermal band-like lipomatous metaplasia and coexisting skin tumors. Read More

Nature 2021 Jun 16. Epub 2021 Jun 16.

Roche/Genentech, South San Francisco, CA, USA.

Minimally invasive approaches to detect residual disease after surgery are needed to identify patients with cancer who are at risk for metastatic relapse. Circulating tumour DNA (ctDNA) holds promise as a biomarker for molecular residual disease and relapse. We evaluated outcomes in 581 patients who had undergone surgery and were evaluable for ctDNA from a randomized phase III trial of adjuvant atezolizumab versus observation in operable urothelial cancer. Read More

J Plast Reconstr Aesthet Surg 2021 Jun 2. Epub 2021 Jun 2.

Kingston Hospital NHS Foundation Trust, Galsworthy Road, Kingston upon Thames KT2 7QB, United Kingdom.

PLoS One 2021 15;16(6):e0253065. Epub 2021 Jun 15.

2nd Department of Pathology, Semmelweis University, Budapest, Hungary.

The presence of autophagy has been indicated in cholangiocarcinoma (CC), which disease has poor prognosis and limited treatment options. Recently, CC has been classified by anatomical localization as intrahepatic (iCC), perihilar (pCC) and distal (dCC), showing different clinical and molecular characteristics. Thus, our aim was to compare autophagy activity in CC samples resected from different anatomical locations. Read More

JAMA Intern Med 2021 Jun 14. Epub 2021 Jun 14.

Department of Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee.

FASEB Bioadv 2021 Jun 17;3(6):459-469. Epub 2021 Mar 17.

Department of Medicine Division of Translational Research Roswell Park Comprehensive Cancer Center Buffalo NY USA.

Vismodegib, a Smoothened antagonist, is clinically approved for treatment of human basal cell carcinoma (BCC), in the clinical trials of medulloblastoma (MB) and other cancers. However, a significant proportion of these tumors fail to respond to Vismodegib after a period of treatment. Here, we find that AMPK agonists, A769662, and Metformin, can inhibit GLI1 activity and synergize with Vismodegib to suppress MB cell growth and . Read More

Gynecol Oncol Rep 2021 Aug 27;37:100797. Epub 2021 May 27.

Division of Gynecologic Oncology, The Ohio State University Wexner Medical Center, M210 Starling Loving Hall, 320 W 10 Avenue, Columbus, OH 43210, United States.

Cervical cancer with co-existing pathologic components of squamous cell carcinoma, basaloid morphology and sarcomatoid carcinoma is rare, with limited reports in the literature. Here we present a patient who underwent a modified radical hysterectomy for cervical cancer, with final pathology specimen demonstrating multiple histologic variants including basal carcinoma, adenoid cystic-like areas, basaloid squamous cell carcinoma and areas of high-grade transformation to sarcomatoid carcinoma. Read More

Plast Reconstr Surg Glob Open 2021 Jun 10;9(6):e3607. Epub 2021 Jun 10.

Department of Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital, Washington, D.C.

Mohs micrographic surgery (MMS) has become the predominant modality of excision for non-melanoma skin cancers (NMSC). Patients are referred for MMS under the assumption that it is the most effective procedure for definitive removal of the cancer while also allowing for maximal tissue preservation to achieve optimal cosmesis. The objective of this study was to investigate outcomes of serial excision (SE) as an alternative excision modality for NMSC. Read More

Carcinogenesis 2021 Jun 12. Epub 2021 Jun 12.

Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.

Uncontrolled activation of the Hedgehog (Hh) signaling pathway, operating through GLI transcription factors, plays a central role in the pathogenesis of cutaneous basal cell carcinoma and contributes to the development of several malignancies arising in extracutaneous sites. We now report that K5-tTA;tetO-Gli2 bitransgenic mice develop distinctive epithelial tumors within their jaws. These tumors consist of large masses of highly proliferative, monomorphous, basaloid cells with scattered foci of keratinization and central necrosis, mimicking human basaloid squamous cell carcinoma (BSCC), an aggressive upper aerodigestive tract tumor. Read More

Sci Rep 2021 Jun 11;11(1):12391. Epub 2021 Jun 11.

Department of Plastic, Reconstructive and Aesthetic Surgery, Second Chair of Surgery Medical, University of Lodz, Lodz, Poland.

Skin cancers are the most common neoplasms; frequently, they localize on the face. The aim of paper is to present the incidence of skin tumors in a single center from 2017 to 2019, describe trends in its frequency and find relations between neoplasms and sex, type of cancer, and its size. An analysis of histopathological files from the surgical department between 2017 and 2019 was calculated. Read More

Photodiagnosis Photodyn Ther 2021 Jun 8:102393. Epub 2021 Jun 8.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, China. Electronic address:

Basal cell carcinoma (BCC) is a common non-melanoma skin malignancy arising in sun exposure area. Patient with multiple BCCs has a high-risk factor for recurrence and is very difficult to be treated with current methods. 5-aminolaevulinic acid-photodynamic therapy (ALA-PDT) is proved to treat superficial type of BCCs with superior efficacy and an excellent cosmetic result, but deep tumor is limited. Read More

J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Departments of Dermatology and Head and Neck Surgery, The University of Texas MD Anderson Cancer, Houston, Texas, USA.

Radiation therapy may be performed for a variety of cutaneous malignancies depending on patient health status, tumor clinical and histologic features, patient preference, and resource availability. Dermatologists should be able to recognize the clinical scenarios in which radiation therapy is appropriate as this may reduce morbidity, decrease risk of disease recurrence, and improve quality of life. The second article in this 2-part continuing medical education series focuses on the most common indications for radiation therapy in the treatment of basal cell carcinoma, cutaneous squamous cell carcinoma, dermatofibrosarcoma protuberans, Merkel cell carcinoma, Kaposi sarcoma, angiosarcoma, cutaneous lymphoma, melanoma, undifferentiated pleomorphic sarcoma, and sebaceous carcinoma. Read More

J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Dermatology, Mater Misericordiae University Hospital, Ireland; School of Medicine, University College Dublin, Ireland.

Clin Exp Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Dermatology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Background: Early and accurate diagnosis of cutaneous squamous cell carcinoma (SCC) and actinic keratosis (AK) is fundamental to reduce their morbidity and to select the correct treatment. Line-field confocal optical coherence tomography (LC-OCT) is a new imaging device that can characterize healthy skin and basal cell carcinoma, but no large studies are available on keratinocyte cell tumours.

Objectives: To identify and describe LC-OCT criteria associated with SCC and AK and to compare LC-OCT findings in these tumours. Read More