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    C-Jun expression in lichen planus, psoriasis and cutaneous squamous cell carcinoma, an immunohistochemical study.
    J Immunoassay Immunochem 2017 Nov 16. Epub 2017 Nov 16.
    c Dermatology Departments , Shibin Elkom Teaching Hospital , Egypt.
    The AP-1 transcription factor complex is a key player in regulating inflammatory processes, cell proliferation, differentiation and cell transformation. The aim of the present study is to investigate C-Jun (one of AP-1complex) expression and its proliferative role in skin samples of lichen planus, psoriasis as common inflammatory skin diseases and squamous cell carcinoma using immunohistochemical method. The present study was carried out on skin biopsies of 15 psoriatic patients, 15 lichen planus patients, 15 SCC and 15 normal skin biopsies. Read More

    Skin Cancer Awareness and Sun Protection Behavior Before and Following Treatment Among Skin Cancer-Treated Patients.
    J Cancer Educ 2017 Nov 15. Epub 2017 Nov 15.
    School of Public Health, Gonabad University of Medical Sciences, Gonabad, Iran.
    There is little known about illness perception in patients with skin tumors. We conducted this study to investigate Iranian patients' understanding of skin tumors, and to evaluate their sun-protective behavior changes after treatment of skin cancer. Patients with a skin biopsy of basal cell carcinoma were asked to complete questionnaires. Read More

    Combined empirical mode decomposition and texture features for skin lesion classification using quadratic support vector machine.
    Health Inf Sci Syst 2017 Dec 30;5(1):10. Epub 2017 Oct 30.
    Department of Computer Science, University of Illinois at Springfield, Springfield, IL USA.
    Purpose: Basal cell carcinoma is one of the most common malignant skin lesions. Automated lesion identification and classification using image processing techniques is highly required to reduce the diagnosis errors.

    Methods: In this study, a novel technique is applied to classify skin lesion images into two classes, namely the malignant Basal cell carcinoma and the benign nevus. Read More

    Histopathological Changes in Tracheal Mucosa Following Total Laryngectomy.
    Coll Antropol 2016 Jun;40(2):123-6
    The aim of this study was to determine the long term histopathologic changes in tracheal mucosa after a total laryngectomy , and to find out the relationship between the progression of histopathologic changes in tracheal mucosa and the duration of breathing through the tracheostomy. Tracheal mucosal biopsies were taken from a total of 35 patients, of both sexes, who underwent a total laryngectomy for laryngeal carcinoma at least one year prior. Histologic specimens of tracheal mucosa were stained with hematoxylin and eosin and examined under light microscopy. Read More

    Cryosurgery for Facial and Scalp Lesions of Basal Cell Carcinoma: A Study in 29 Elderly Patients.
    Skinmed 2017 1;15(5):357-364. Epub 2017 Oct 1.
    Dermato-Venereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati Delhi, India.
    Basal cell carcinoma (BCC) is one of the pre-eminent tumors of the epidermis, recognized by explicit clinical-pathologic characteristics. It is relatively uncommon in South Asia including India and is amenable to a variety of modalities, including cryosurgery. The outcome of cryosurgery was evaluated in 18 men and 11 women, aged 58 to 83 years, who were treated with two freeze-thaw cycles of liquid nitrogen under local anesthesia, after requisite preparations. Read More

    Effect of light polarization on the efficiency of photodynamic therapy of basal cell carcinomas: an in vitro cellular study.
    Lasers Med Sci 2017 Nov 15. Epub 2017 Nov 15.
    Department of Anatomy, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
    In an in vitro study, the effect of light polarization on the efficiency of 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) of basal cell carcinoma (BCC) was investigated. Three states of light polarization (non-polarized, linearly polarized, and circularly polarized) were considered. Cells were exposed to green (532 pm 20 nm) irradiation from light emitting diodes. Read More

    Downregulation of the Sonic Hedgehog/Gli pathway transcriptional target Neogenin-1 is associated with basal cell carcinoma aggressiveness.
    Oncotarget 2017 Oct 19;8(48):84006-84018. Epub 2017 Sep 19.
    Laboratory of Stem Cells and Developmental Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile.
    Basal Cell Carcinoma (BCC) is one of the most diagnosed cancers worldwide. It develops due to an unrestrained Sonic Hedgehog (SHH) signaling activity in basal cells of the skin. Certain subtypes of BCC are more aggressive than others, although the molecular basis of this phenomenon remains unknown. Read More

    Atomic force microscopy study revealed velocity-dependence and nonlinearity of nanoscale poroelasticity of eukaryotic cells.
    J Mech Behav Biomed Mater 2017 Nov 11;78:65-73. Epub 2017 Nov 11.
    Department of Mechanical Engineering, Iowa State University, Ames, IA 50011, USA. Electronic address:
    Intracellular network deformation of the cell plays an important role in cellular shape formation. Recent studies suggest that cell reshaping and deformation due to external forces involve cellular volume, pore size, elasticity, and intracellular filaments polymerization degree change. This cell behavior can be described by poroelastic models due to the porous structure of the cytoplasm. Read More

    Chromosome 9 mutations reported absent in some patients with Basal Cell Carcinoma Nevus Syndrome.
    J Eur Acad Dermatol Venereol 2017 Nov 14. Epub 2017 Nov 14.
    University of Central Florida College of Medicine, Orlando, Florida.
    Basal Cell Carcinoma Nevus Syndrome (BCCNS), also known as Gorlin syndrome, is a rare autosomal dominant condition with a substantial disease burden, thought to occur secondary to chromosome 9 mutation evoking a Hedgehog (Hh) signaling aberration that leads to early development of numerous basal cell carcinomas (BCCs). Individuals with BCCNS also present with keratocystic odontogenic tumors, medulloblastomas, and palmar or plantar pits1. This condition demonstrates variable expressivity, leading to differing phenotypes, even within the same family2. Read More

    Cytokeratin Profile of Basal Cell Carcinomas According to the Degree of Sun Exposure and to the Anatomical Localization.
    Am J Dermatopathol 2017 Nov 1. Epub 2017 Nov 1.
    *Department of Dermatology, University Hospital Arnau de Vilanova, Lleida, Spain; †Biomedical Research Institute of Lleida (IRBLleida), Lleida, Spain; ‡Department of Pathology, University Hospital Arnau de Vilanova, Lleida, Spain; §Department of Dermatology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain; and ¶Department of Medicine, University of Lleida, Lleida, Spain.
    Basal cell carcinoma (BCC) seems to originate from ultraviolet light-induced mutations involving the bulge or the outer sheath of the hair follicle cells. However, the etiopathogenic mechanisms involved in the development of these tumors in nonphotoexposed and in hairless areas remain unclear. The cytokeratin (CK) profile (including CK5/6, CK7, CK14, CK15, CK17, and CK19) from a series of different BCC subtypes developing in sun-exposed and non-sun-exposed areas, including hairless regions, was evaluated. Read More

    Efficiency of electrochemotherapy with reduced bleomycin dose in the treatment of nonmelanoma head and neck skin cancer: Preliminary results.
    Head Neck 2017 Nov 11. Epub 2017 Nov 11.
    Institute of Oncology Ljubljana, Ljubljana, Slovenia.
    Background: In the present study, effectiveness of electrochemotherapy was compared in patients with nonmelanoma skin cancer (NMSC) of the head and neck using standard and reduced doses of bleomycin.

    Methods: Twenty-eight patients older than 65 years were prospectively treated with electrochemotherapy for nonmelanoma head and neck skin cancer. In the experimental group (n = 12 patients; 24 lesions), reduced bleomycin doses (10 000 IU/m(2) ) were used. Read More

    UV-Induced Molecular Signaling Differences in Melanoma and Non-melanoma Skin Cancer.
    Adv Exp Med Biol 2017 ;996:27-40
    Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.
    There are three major types of skin cancer: melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC and SCC are often referred to as non-melanoma skin cancer (NMSC). NMSCs are relatively non-lethal and curable by surgery, hence are not reportable in most cancer registries all over the world. Read More

    Trendy Tattoos-Maybe a Serious Health Risk?
    Aesthetic Plast Surg 2017 Nov 9. Epub 2017 Nov 9.
    Department of Plastic, Aesthetic, Reconstructive and Hand Surgery, AGAPLESION Diakonieklinikum Rotenburg, Elise-Averdieck-Straße 17, 27356, Rotenburg (Wümme), Germany.
    Background: The literature reports many cases of cutaneous malignancy in the setting of skin tattoos. In this study, we review the reported incidence of and risk factors for tattoo-associated skin cancer.

    Methods: A PubMed literature review was performed for all cases of tattoo-associated skin cancer, including squamous cell carcinoma, basal cell carcinoma, malignant melanoma, keratoacanthoma, and other rare skin malignancies (source: PubMed/until June 2017). Read More

    Transcriptomic analyses reveal the underlying pro-malignant functions of PTHR1 for osteosarcoma via activation of Wnt and angiogenesis pathways.
    J Orthop Surg Res 2017 Nov 9;12(1):168. Epub 2017 Nov 9.
    Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, 44, Xiaoheyan Road, Dadong District, Shenyang, Liaoning, 110042, China.
    Background: Increasing evidence has indicated parathyroid hormone type 1 receptor (PTHR1) plays important roles for the development and progression of osteosarcoma (OS). However, its function mechanisms remain unclear. The goal of this study was to further illuminate the roles of PTHR1 in OS using microarray data. Read More

    Treatment of advanced basal cell carcinoma with sonidegib: perspective from the 30-month update of the BOLT trial.
    Future Oncol 2017 Nov 9. Epub 2017 Nov 9.
    Department of Dermatology, The University of Texas McGovern Medical School at Houston, Houston, TX 77030, USA.
    Sonidegib, a hedgehog pathway inhibitor, was approved by the US FDA for the treatment of locally advanced basal cell carcinoma which cannot be readily treated with surgery or radiotherapy. The pharmacology and pharmacokinetics of sonidegib will be discussed in this review. Additionally, an in-depth analysis of the BOLT trial and data from the 30-month update will be included. Read More

    Actinic keratosis area and severity index (AKASI) is associated with the incidence of squamous cell carcinoma.
    J Eur Acad Dermatol Venereol 2017 Nov 8. Epub 2017 Nov 8.
    CentroDerm Clinic, Heinz-Fangman-Straße 57, Wuppertal, Germany.
    Background: Actinic keratoses (AKs) are commonly diagnosed clinically. Actinic keratosis area and severity index (AKASI) is a new easy-to-use tool to assess the severity of AK on the head.

    Objective: To determine the association between chronically UV-induced tumours such as basal cell carcinomas (BCC) or squamous cell carcinomas (SCC) and AKASI. Read More

    Differential expression of cyclin D1, Ki‑67, pRb, and p53 in psoriatic skin lesions and normal skin.
    Mol Med Rep 2017 Nov 8. Epub 2017 Nov 8.
    Department of Dermatology, Keimyung University School of Medicine, Jung‑Gu, Daegu 41931, Republic of Korea.
    Psoriasis is a hyperproliferative inflammatory skin disease; therefore, it is highly likely that psoriatic skin lesions may transform into malignancies. However, malignant transformation is not common. We performed immunohistochemical studies using anti‑cyclin D1, anti‑cyclin E, anti‑pRb, anti‑p53, anti‑p16INK4a, and anti‑Ki‑67 antibodies in normal skin, psoriatic epidermal tissue, and squamous cell carcinoma (SCC) tissue. Read More

    XIAP underlies apoptosis resistance of renal cell carcinoma cells.
    Mol Med Rep 2017 Oct 27. Epub 2017 Oct 27.
    Department of Urology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China.
    X‑linked inhibitor of apoptosis (XIAP), a key member of the inhibitors of apoptosis protein family, can inhibit apoptosis by directly binding to the initiator caspase‑9, ‑3 and ‑7, thereby promoting tumor cell survival during tumor progression. In the present study, XIAP basal expression levels were investigated and its contribution to the resistance to apoptosis was evaluated, in the RCC cell lines exposed to apoptosis‑inducing drugs. This was investigated by histological methods and western blot analysis. Read More

    Risk of skin cancer among patients with myotonic dystrophy type 1 based on Primary care physician data from the United Kingdom Clinical Practice Research Datalink.
    Int J Cancer 2017 Nov 7. Epub 2017 Nov 7.
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
    Myotonic dystrophy type 1 (DM1) is an inherited multisystem neuromuscular disorder caused by a CTG trinucleotide repeat expansion in the DMPK gene. Recent evidence documents that DM1 patients have an increased risk of certain cancers, but whether skin cancer risks are elevated is unclear. Using the U. Read More

    Expression of β1integrin in normal epithelium, oral submucous fibrosis and oral squamous cell carcinoma.
    Pathol Res Pract 2017 Oct 26. Epub 2017 Oct 26.
    Department of Oral and Maxillofacial Pathology, Rajah Muthaih Dental College and Hospital, Annamalai University, Annamalai Nagar, Chidhambaram, Tamil Nadu, India. Electronic address:
    Introduction And Aims: The possible reason suggested for epithelial atrophy in oral submucous fibrosis (OSMF) is ischemia. Dysregulation in the epithelial proliferation and maturation is also thought to be a cause. The β1 integrin identifies the oral epithelial stem cells. Read More

    Occupational UV-exposure is a Major Risk Factor for Basal Cell Carcinoma: Results of the Population-Based Case-Control Study FB-181.
    J Occup Environ Med 2017 Nov 3. Epub 2017 Nov 3.
    Center of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden, Germany (Jochen Schmitt, Eva Haufe, Freya Trautmann, Thoralf Stange); Institute and Outpatient Clinics of Occupational and Social Medicine, Medical Faculty Carl Gustav Carus, TU Dresden, Germany (Eva Haufe, Andreas Seidler); Department of Dermatology, Dermatological Radiotherapy and Dermatohistopathology, Special Clinics Hornheide, Germany (Hans-Joachim Schulze, Susanne Dugas-Breit); Department of Dermatology, University Hospital Jena, Germany (Peter Elsner, Michal Gina); Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Germany (Hans Drexler, Wobbeke Weistenhöfer); Department of Dermatology, UniversityAllergyCenter, Medical Faculty Carl Gustav Carus, TU Dresden, Germany (Andrea Bauer, Ilka Bruhn); Institute of Occupational, Social and Environmental Medicine, University Medical Center, Johannes-Gutenberg University Mainz, Germany (Stephan Letzel); Department of Dermatology, Environmental Health and Health Theory, University of Osnabrück and Institute of Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Osnabrück, Germany (Swen Malte John); Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (DGUV), Institute of Ruhr-University Bochum (IPA), Germany (Manigé Fartasch, Thomas Brüning); Department of Clinical Social Medicine, Occupational and Environmental Dermatology, University of Heidelberg, Germany (Klaus Bachmann, Thomas Ludwig Diepgen); Department of Dermatology, University Medical Center, Johannes-Gutenberg University Mainz, Germany (Berenice Mareen Lang); Institute of Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Employer's Liability Insurance Association Clinics Hamburg, Hamburg, Germany (Sonja Bonness); Department of Dermatology and Allergy, University Bonn, Bonn, Germany (Jean Pierre Allam, William Grobe); Department of Radiation, Institute of Occupational Health and Safety of the German Social Accident Insurance (DGUV), Sankt Augustin, Germany (Stephan Westerhausen, Marc Wittlich); Department of Dermatology, Experimental Photobiology, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany (Peter Knuschke).
    Objective: To investigate to role of occupational and non-occupational UV-exposure concerning the development of basal cell carcinoma (BCC).

    Methods: We undertook a population-based multi-center case-control study. Patients with first incident BCC (n = 836) were propensity score matched by age and sex to controls without skin cancer (n = 836). Read More

    Genomic Stability in Syndromic Basal Cell Carcinoma.
    J Invest Dermatol 2017 Oct 27. Epub 2017 Oct 27.
    Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:
    Basal cell cancers (BCCs) are characterized by up-regulation of Hedgehog pathway through loss of Patched1 or activation of Smoothened, and smoothened-inhibitors such as vismodegib are effective therapies for advanced BCCs. Although most BCCs are sporadic, rare individuals with Basal Cell Nevus Syndrome (BCNS) harbor germline defects in Patched1 and develop up to hundreds of tumors that are histopathologically indistinguishable from sporadic BCCs. Interestingly, BCNS-BCCs are more responsive to Smoothened-inhibitors than sporadic BCCs, with minimal development of resistance. Read More

    Ulcerated Metatypical Basal Cell Carcinoma of the Forehead.
    Open Access Maced J Med Sci 2017 Oct 3;5(6):807-809. Epub 2017 Oct 3.
    Medical Institute of the Ministry of Interior, Dermatology, Venereology and Dermatologic Surgery; Onkoderma, Private Clinic for Dermatologic Surgery, Dermatology and Surgery, Sofia, Bulgaria.
    An 81-year-old male presented with an ulcerated lesion on the frontal area. The lesion had started three years before with a small ulceration and was initially treated with a cream of betamethasone and fusidic acid twice daily for several months. The clinical impression was ulcerated basal cell carcinoma (BCC). Read More

    Updates on the Management of Non-Melanoma Skin Cancer (NMSC).
    Healthcare (Basel) 2017 Nov 1;5(4). Epub 2017 Nov 1.
    Division of Plastic and Reconstructive Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
    Non-melanoma skin cancers (NMSCs) are the most common malignancy worldwide, of which 99% are basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of skin. NMSCs are generally considered a curable diseases, yet they currently pose an increasing global healthcare problem due to rising incidence. This has led to a shift in emphasis on prevention of NMSCs with development of various skin cancer prevention programs worldwide. Read More

    Skin cancer associated with commonly prescribed drugs: tumor necrosis factor alpha inhibitors (TNF-αIs), angiotensin-receptor blockers (ARBs), phosphodiesterase type 5 inhibitors (PDE5Is) and statins -weighing the evidence.
    Expert Opin Drug Saf 2017 Nov 8:1-9. Epub 2017 Nov 8.
    a Department of Dermatology , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.
    Introduction: Skin cancers, including both malignant melanoma (MM) and nonmelanoma skin cancer (NMSC), are the most commonly diagnosed cancers in the US. The incidence of both MM and NMSC continues to rise. Areas covered: Current evidence for an association between four of the most commonly prescribed classes of drugs in the U. Read More

    Stain-free Histopathology of Basal Cell Carcinoma by Dual Vibration Resonance Frequency CARS Microscopy.
    Pathol Oncol Res 2017 Nov 4. Epub 2017 Nov 4.
    Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary.
    Basal cell carcinoma (BCC) is the most common malignancy in Caucasians. Nonlinear microscopy has been previously utilized for the imaging of BCC, but the captured images do not correlate with H&E staining. Recently, Freudiger et al. Read More

    FT-IR Spectroscopy Study in Early Diagnosis of Skin Cancer.
    In Vivo 2017 Nov-Dec;31(6):1131-1137
    Laboratory of Radiation Chemistry & Biospectroscopy, Chemical Engineering School, National Technical University of Athens, Athens, Greece
    Background/aim: Mid-infrared spectroscopy (4000-500 cm(-1)) was used to analyze the spectral changes and differences of the characteristic absorption bands of the skin components due to cancer development for early clinical diagnosis.

    Materials And Methods: Human biopsies from basal cell carcinoma, malignant melanoma, and nevus were used, while normal skin tissue served as a control.

    Results: The high quality of Fourier-transform infrared (FT-IR) spectra showed that upon cancer development the intensity of the absorption band at approximately 3062 cm(-1) was increased, indicating that most of the proteins had the configuration of amide B and the β-sheet protein structure predominated. Read More

    Combination Vismodegib and Photodynamic Therapy for Multiple Basal Cell Carcinomas.
    Photodiagnosis Photodyn Ther 2017 Nov 1. Epub 2017 Nov 1.
    Department of Dermatology, University of Arizona and University of Arizona Cancer Center at Dignity Health, Phoenix, Arizona, 85004, USA. Electronic address:
    Background: Oral vismodegib therapy and photodynamic therapy (PDT) are non-invasive treatments for basal cell carcinoma (BCC) with overlapping utility in widespread BCCs and patients who are poor surgical candidates. There is no published study to date investigating the combination use of PDT with vismodegib to optimize individual response rates.

    Objective: To evaluate the combination of red light PDT and vismodegib therapy in patients with multiple nodular BCCs. Read More

    Does Surgical Fragmentation of Odontogenic Keratocystic Capsule Interfere With the Recurrence Rate?
    J Oral Maxillofac Surg 2017 Oct 13. Epub 2017 Oct 13.
    Professor, Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address:
    Purpose: We hypothesized that fragmentation of the cystic capsule during surgery would influence the recurrence rate of odontogenic keratocysts (OKCs) regardless of the treatment modality chosen.

    Materials And Methods: We reviewed, in a retrospective study, cases diagnosed as OKCs on histopathologic examination at the oral pathology department between 1991 and 2013. Fragmentation data were obtained from the records of the oral surgical department. Read More

    Effects of photodynamic therapy on dermal fibroblasts from xeroderma pigmentosum and Gorlin-Goltz syndrome patients.
    Oncotarget 2017 Sep 24;8(44):77385-77399. Epub 2017 Aug 24.
    Department of Biology, Faculty of Sciences, Autónoma University of Madrid, IRYCIS, Madrid, Spain.
    PDT is widely applied for the treatment of non-melanoma skin cancer pre-malignant and malignant lesions (actinic keratosis, basal cell carcinoma and in situ squamous cell carcinoma). In photodynamic therapy (PDT) the interaction of a photosensitizer (PS), light and oxygen leads to the formation of reactive oxygen species (ROS) and thus the selective tumor cells eradication. Xeroderma pigmentosum (XP) and Gorlin-Goltz Syndrome (GS) patients are at high risk of developing skin cancer in sun-exposed areas. Read More

    A spontaneous basal cell carcinoma with pulmonary metastasis in a 6-week-old SD rat.
    J Toxicol Pathol 2017 Oct 11;30(4):323-326. Epub 2017 Jun 11.
    Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., 2438 Miyanoura, Kagoshima 891-1394, Japan.
    To our knowledge, this is the first report on basal cell carcinoma with lung metastasis in a rat. A 6-week-old male Sprague-Dawley rat presented ulceration of the oral mucosa with surrounding tumor growth and white nodules in the lung. Microscopically, the mass showed solid, sheet-like growth with a partially lobular pattern and invaded the gingival mucosa, maxilla, and nasal submucosa. Read More

    Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment.
    JCI Insight 2017 Nov 2;2(21). Epub 2017 Nov 2.
    Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA.
    Advanced basal cell carcinomas (BCCs) circumvent Smoothened (SMO) inhibition by activating GLI transcription factors to sustain the high levels of Hedgehog (HH) signaling required for their survival. Unfortunately, there is a lack of efficacious therapies. We performed a gene expression-based drug repositioning screen in silico and identified the FDA-approved histone deacetylase (HDAC) inhibitor, vorinostat, as a top therapeutic candidate. Read More

    Basal Cell Carcinoma of Vermilion Mucosa of Upper Lip: a Rare Case Report.
    Acta Med Indones 2017 Jul;49(3):255-258
    Department of Dermatology, Jundishapur University of Medical Sciences, Ahvaz, Iran.
    Although basal cell carcinoma (BCC) is a common skin tumor, very rare cases of BCC arising from upper vermilion mucosa of lip have been reported previously. This tumor basically, originates from pillar structures and the involvement of the vermilion lip contrasts this concept so it is devoid of hair follicles and sweat glands. The exact pathogenesis of vermilion lip BCC is not clear but it has been postulated that the neoplasm originates from the pluripotential epithelial cells of the oral mucosa and epidermis. Read More

    Nonsyndromic Multiple Basal Cell Carcinomas.
    Arch Craniofac Surg 2017 Sep 26;18(3):191-196. Epub 2017 Sep 26.
    Department of Plastic and Reconstructive Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Basal cell carcinoma (BCC) comprising several lesions is not uncommon, but nonsyndromic multiple BCCs with parotid invasion are rare entities. We present two cases of multiple sporadic, nonsyndromic BCCs, and one of these cases is a unique case of parotid invasion associated purely with actinic keratosis. In Case 1, a 79-year-old female presented with multiple skin lesions on the face and left hand. Read More

    A relapsed lower lip squamous cell carcinoma treated with curative electrochemotherapy in elderly patient.
    Minerva Stomatol 2017 Oct 31. Epub 2017 Oct 31.
    Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
    Introduction: ECT is normally used in the treatment of basal cell carcinoma, cutaneous and subcutaneous tumours, metastases of melanoma, Kaposi sarcoma, because of its high power, safety and low toxicity. The ECT treatment efficacy depends on the drug concentration during the use, patient characteristics, the distribution of the electric field inside the tumour and the tumour characteristics.

    Aim: The aim of this study was to evaluate the effect of ECT in a patient affected by relapsed lower lip squamous cell carcinoma, not candidate for traditional surgery but treated for persistent pain with swallowing and breathing difficulties. Read More

    Analysis of dermoscopy teaching modalities in United States dermatology residency programs.
    Dermatol Pract Concept 2017 Jul 31;7(3):38-43. Epub 2017 Jul 31.
    Department of Dermatology & Department of Family and Community Medicine, Penn State Hershey Medical Center, Hershey, PA, USA.
    The use of dermoscopy in dermatology residency programs is on the rise (over 94% of chief residents reported using a dermatoscope in 2013) [1]. Despite increased use (100% of our surveyed residents reported using a dermatoscope), dermoscopy training is one of the aspects of United States dermatology residency training with the lowest resident satisfaction [2]. Diagnostic accuracy with dermoscopy is highly correlated with the amount of dermoscopy training the user has undertaken [3]. Read More

    Reticulated acanthoma with sebaceous differentiation mimicking melanoma.
    Dermatol Pract Concept 2017 Jul 31;7(3):35-37. Epub 2017 Jul 31.
    Department of Dermatology, Mogi das Cruzes University, Mogi das Cruzes, Brazil.
    Reticulated acanthoma with sebaceous differentiation (RASD) is a rare, benign cutaneous tumor with peculiar histopathologic characteristics [1]. RASD had been described under various synonyms such as superficial epithelioma with sebaceous differentiation, sebocrine adenoma, poroma with sebaceous differentiation, and seborrheic keratosis with sebaceous differentiation [2]. Clinical differential diagnosis of RASD includes cutaneous superficial epithelial neoplasia such as Bowen's disease, superficial basal cell carcinoma (BCC) and intraepidermal eccrine poroma [1]. Read More

    Establishment and characterization of a triple negative basal-like breast cancer cell line with multi-drug resistance.
    Oncol Lett 2017 Oct 23;14(4):5039-5045. Epub 2017 Aug 23.
    Department of Pathology, Kazan State Medical University, Kazan 420012, Russia.
    Triple-negative breast carcinoma (TNBC) is one of the most aggressive subtypes of breast cancer and is associated with an unfavorable prognosis. The management of TNBC is currently based on the use of classical cytotoxic drugs, i.e. Read More

    Whole-exome sequencing to identify novel mutations of nevoid basal cell carcinoma syndrome in a Chinese population.
    Cancer Biomark 2017 Oct 20. Epub 2017 Oct 20.
    Background: Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disease with a complex genetic etiology. Although three causative genes (PTCH1, PTCH2, SUFU) have been identified through linkage analysis and Sanger sequencing, the genetic background of NBCCS hasn't been fully understood.

    Methods: We performed a whole-exome sequencing (WES) in a Han Chinese NBCCS family and two unaffected volunteers to search for its causative gene. Read More

    Gamma knife radiosurgery for basal cell carcinoma of the eyelid: report of a case.
    Acta Neurochir (Wien) 2017 Oct 28. Epub 2017 Oct 28.
    Gamma House, Steel Memorial Yawata Hospital, Kitakyushu, Japan.
    Basal cell carcinoma (BCC) is the most common malignancy in the face. Surgical removal and reconstruction is the first choice of treatment options for BCC, but it tends to be invasive and sometimes is accompanied by a drastic change in appearance. We report here a case of BCC in the eyelid of a patient who was successfully treated by gamma knife radiosurgery (GKRS). Read More

    Activation of Wnt-β-catenin pathway in basal-parabasal layers of normal cervical epithelium comparable during development of uterine cervical carcinoma.
    Mol Cell Biochem 2017 Oct 27. Epub 2017 Oct 27.
    Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata, 700026, West Bengal, India.
    In this study, importance of Wnt-β-catenin pathway in the development of uterine cervical carcinoma was evaluated. For this purpose, the profiles (expression/methylation/deletion) of β-catenin, p-β-catenin (Y654), Wnt3a, and APC were studied in disease free normal cervical epithelium (n = 9), adjacent normal cervical epithelium of primary tumors (n = 70), CIN (n = 28), CACX (n = 102) samples, and two CACX cell lines (HeLa and SiHa). Immunohistochemical analysis revealed high/medium (74-95%) expression of β-catenin/p-β-catenin (Y654) and Wnt3a and low expression (23-26%) of APC in proliferating basal-parabasal layers contrary to differentiated spinous layer in normal cervix irrespective of HPV16 infection. Read More

    [Diagnosis Related Groups in reconstructive plastic surgery of malignant head and neck skin tumours].
    Handchir Mikrochir Plast Chir 2017 Oct 26. Epub 2017 Oct 26.
    St. Marien-Hospital Borken, Klinikum Westmünsterland, Klinik für Plastische und Ästhetische Chirurgie.
    Background Diagnosis Related Groups (DRGs) were introduced in Germany as a medico-economic classification system 13 years ago. In this analysis, we looked into the compensation for reconstructive plastic surgery after the excision of malignant head and neck skin tumours by DRGs. Material and methods Four main diagnoses (malignant melanoma, basal cell carcinoma, squamous cell carcinoma, carcinoma in situ) at a maximum of 6 different locations in the head and neck were combined with the following procedures: excision and primary wound closure, excision with temporary soft tissue coverage, split-thickness or full-thickness skin grafting, local, free or regional pedicle flaps, distant flaps as well as combined procedures for coverage. Read More

    Basal cell carcinoma of the scalp with destruction and invasion into the calvarium and dura mater: Report of 7 cases and review of literature.
    J Clin Neurosci 2017 Oct 23. Epub 2017 Oct 23.
    Department of Neurosurgery, Vilnius Univeristy Hospital, Vilnius, Lithuania.
    Basal cell carcinoma (BCC) is the most common skin malignancy in humans. Giant BCC is a rarer entity that is characterised by aggressive biological behaviour. Intracranial invasion by a BCC on the scalp is extremely rare. Read More

    Tetracycline use and risk of incident skin cancer: a prospective study.
    Br J Cancer 2017 Oct 26. Epub 2017 Oct 26.
    Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI, USA.
    Background: Tetracycline is a photosensitising medication that increases skin vulnerability to UV-related damage.

    Methods: We prospectively examined tetracycline use and risk of incident melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) based on 213 536 participants from the Nurses' Health Study (NHS), NHS2, and Health Professionals Follow-up Study. Information on ever use of tetracycline was asked via questionnaire. Read More

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