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Photodiagnosis Photodyn Ther 2019 Apr 16. Epub 2019 Apr 16.

Skin Department, Foundation Hospital Amaral Carvalho, Jau, São Paulo, Brazil. Electronic address:

Non-melanoma skin cancer is the most prevalent type of cancer in Brazil and worldwide. Topical Photodynamic Therapy is a technique that offers advantages as: excellent aesthetic result, possibility of application for outpatients in ambulatory, and presenting a minimum functional impact of the treated anatomycal site. Fractionated Photodynamic Therapy is a modification of the usual technique in which the full dose of light is delivered in steps separated by a periods of time ("dark intervals"). Read More

J Cosmet Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Dermatological Surgery & Laser Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

Lasers are fast becoming the vogue of dermatology ranging from ablative, nonablative, fractional photothermolysis to vascular lasers. There are a range of vascular lasers including potassium titanyl phosphate (KTP 532 nm), pulsed dye laser (PDL -595 nm), diode (810 nm), and Nd:YAG (1064 nm). PDL is a laser that emits yellow light using Rhodamine dye as it is lasing medium. Read More

Ophthalmologe 2019 Apr 18. Epub 2019 Apr 18.

Klinik für Augenheilkunde, Universitätsklinikum Münster, Domagkstr. 15, 48149, Münster, Deutschland.

Background: Primary basal cell carcinoma (BCC) of the caruncle is an extremely rare entity. Overall, only a few cases are described in the literature. With respect to the S2k guidelines on basal cell carcinoma of the skin, the eyelids, eyebrows and periorbital regions are regarded as zones with a high risk of recurrence. Read More

BMC Cancer 2019 Apr 18;19(1):366. Epub 2019 Apr 18.

Universitätsklinikum Schleswig-Holstein, Schittenhelmstr, 7, D-24 105, Kiel, Germany.

Following publication of the original article [1], it was reported that the legend for Fig. 1 was incomplete. The complete figure legend is. Read More

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Boulevard 5/7, 295051 Simferopol, Crimea.

Skin cancer has always been and remains the leader among all tumors in terms of occurrence. One of the main factors responsible for skin cancer, natural and artificial UV radiation, causes the mutations that transform healthy cells into cancer cells. These mutations inactivate apoptosis, an event required to avoid the malignant transformation of healthy cells. Read More

Med Mol Morphol 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disease characterized by the development of multiple jaw keratocysts and basal cell carcinomas (BCC) and accompanied by diverse phenotypes. The establishment of diagnosis lies on the identification of a heterozygous germline pathogenic variant in the patched homolog 1 gene (PTCH1). PTCH1 has alternative splicing and selective initial coding exon, leading to three types of encoding proteins (PTCHL, PTCHM and PTCHS). Read More

Clin Case Rep 2019 Apr 19;7(4):672-674. Epub 2019 Feb 19.

Department of Dermatology, College of Medicine King Khalid University Hospital Riyadh Saudi Arabia.

Dermatofibroma (DF; Benign Fibrous Histiocytoma) seldom presents on the face. We present an unusual case presentation of translucent nodule on the upper right cheek of the face which was diagnosed clinically as basal cell carcinoma. Physician should include DF in the differential of such lesions. Read More

J Surg Case Rep 2019 Apr 12;2019(4):rjz105. Epub 2019 Apr 12.

Department of General Surgery, Brandon Regional Hospital, Brandon, FL 33511, USA.

Chronic lymphedema (CL) due to failure of lymphatic drainage harbors an immunologically vulnerable environment for the development of various neoplasms. Independently, either melanoma or basal cell carcinoma (BCC) arising from CL has only been reported, but synchronous melanoma and BCC originating from CL is never reported. We report a very rare case of synchronous melanoma and BCC arising from the lymphedematous upper extremity developed secondary to axillary lymphadenectomy for breast cancer. Read More

Klin Onkol 2019 ;32(2):124-128

Background: Gorlin-Goltz syndrome is an autosomal dominant inherited disorder characterized by a predisposition to various cancers. Clinicopathological findings of syndrome are very diverse and many symptoms begin to manifest in a certain period of life.

Case: The authors describe a case report of a man who, at the age of 34 years, presented to a dermatologist with multiple tumor lesions of the skin. Read More

Int J Mol Sci 2019 Apr 16;20(8). Epub 2019 Apr 16.

Department of Science, University of Basilicata, 85100 Potenza, Italy.

Mitochondrial carriers catalyse the translocation of numerous metabolites across the inner mitochondrial membrane, playing a key role in different cell functions. For this reason, mitochondrial carrier gene expression needs tight regulation. The human gene, encoding for the mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), catalyses the electrogenic exchange of aspartate for glutamate plus a proton, thus taking part in many metabolic processes including the malate-aspartate shuttle. Read More

Oman Med J 2014 May;29(3):e073

Department of Morbid Anatomy and Histopathology, University of Health Sciences-54600, Lahore, Pakistan.

Xeroderma pigmentosum is an uncommon inherited autosomal recessive disorder. Affected patients have a 2000-fold amplified risk of skin cancer. There is an inability to repair the damage to genetic material caused by ultraviolet light. Read More

Expert Opin Drug Deliv 2019 Apr 17. Epub 2019 Apr 17.

a School of Pharmaceutical Sciences , University of Geneva & University of Lausanne , 1 Rue Michel Servet, 1211 Geneva , Switzerland.

Background: The aim was to investigate cutaneous delivery and biodistribution of the hedgehog pathway inhibitor, vismodegib (VSD), indicated for basal cell carcinoma (BCC), from polymeric micelle formulations under infinite/finite dose conditions.

Methods: VSD-loaded micelles were characterized for drug content, particle size and shape; a micelle gel was characterized for its rheological behavior. Cutaneous deposition and biodistribution of VSD were determined using porcine and human skin in vitro with quantification by UHPLC-MS/MS. Read More

JAMA Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, University of Southern California, Los Angeles.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

J Clin Aesthet Dermatol 2019 Mar 1;12(3):40-43. Epub 2019 Mar 1.

Drs. Paninson, Trope, and Ramos-e-Silva are with the Sector of Dermatology, Postgraduation Course in Dermatology at the University Hospital and School of Medicine, Federal University of Rio de Janeiro in Rio de Janeiro, Brazil.

The nevus sebaceous of Jadassohn, usually present at birth, is a hamartoma composed predominantly of sebaceous glands, which can progress to benign and malignant tumors. Malignant neoplasms on the nevus sebaceous occur in about 2.5 percent of cases, with basal cell carcinoma accounting for 1. Read More

J Clin Aesthet Dermatol 2019 Mar 1;12(3):12-14. Epub 2019 Mar 1.

Drs. Wetzel and Haeberle and Mr. Brown are with the Division of Dermatology, Department of Medicine, University of Louisville School of Medicine in Louisville, Kentucky.

Dermal invasion is characteristic of more aggressive basal cell carcinoma (BCC) tumors. However, reporting the depth of invasion of BCC is not currently a standard or recommended practice. The purpose of this study was to document the depth of invasion of BCC. Read More

J Clin Med 2019 Apr 3;8(4). Epub 2019 Apr 3.

Department of Dermatology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Current national and European guidelines recommend distinct management approaches for basal cell carcinoma (BCC) based on tumor location, size, and histopathological subtype. In vivo reflectance confocal microscopy (RCM) is a non-invasive skin imaging technique which may change the diagnostic pathway for BCC patients. This study aimed to determine the sensitivity and specificity of RCM for BCC diagnosis, assess the predictive values of several confocal criteria in correctly classifying BCC subtypes, and evaluate the intraobserver reliability of RCM diagnosis for BCC. Read More

Molecules 2019 Apr 2;24(7). Epub 2019 Apr 2.

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.

A phytochemical investigation of the roots of led to the isolation of seven polyacetylenes, including five new compounds (-) and two known ones (-). Their structures were elucidated by extensive spectroscopic analysis and detailed comparison with reported data. All the isolates were tested for their cytotoxicity against the human hepatocellular carcinoma cell line BEL-7402, human myeloid leukemia cell line K562, and human gastric carcinoma cell line SGC-7901. Read More

J Med Chem 2019 Apr 15. Epub 2019 Apr 15.

Important steps in embryonic development are governed by the Hedgehog (Hh) signaling pathway, an evolutionary conserved signal transduction cascade. However, Hh activity is not only crucial during embryo formation, but is also involved in adult tissue repair and in several malignancies. Particularly due to its link to cancer, small molecule Hh pathway inhibitors have been developed and the first compounds have been approved for use in Hh-driven basal cell carcinoma. Read More

J Family Med Prim Care 2019 Feb;8(2):717-721

Department of Cardiology, Ilam University of Medical Sciences, Ilam, Iran.

Introduction: Skin cancer, the melanoma type of which causes high mortality, is the most common malignancy in Iran and all over the world. UV is the most important cause of the incidence of this disease. This study evaluates the frequency of different types of cancer and their trajectory in Ilam province from 2012 to 2011. Read More

Indian J Dermatol 2019 Mar-Apr;64(2):155-157

Department of Pathology, Istanbul Training and Research Hospital, Istanbul, Turkey.

Coexistence of two types of malignant neoplasms, called 'a collision tumor,' is relatively uncommon. Basal cell carcinomas (BCCs) are known to coexist with other cutaneous lesions, but the collision of BCC with malignant melanoma is rare. We report a rare case of BCC with underlying lentigo maligna melanoma, focusing on dermoscopic and reflectance confocal microscopic (RCM) findings and their correlation with histopathology. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):471-474

Department of Plastic Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433,

Objective: To explore the effectiveness of keystone flap in repairing skin and soft tissue defects around joint.

Methods: Between March 2013 and December 2017, 10 patients of skin and soft tissue defects around the joint were repaired with keystone flaps. There were 6 males and 4 females. Read More

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Baskent University Istanbul Hospital Dermatology Clinic, Istanbul.

Pigmented and irritated types of seborrheic keratosis (SK) can be confused with melanoma, basal cell carcinoma, or pigmented actinic keratosis. Dermoscopic examination may give many clues for the diagnosis of SK, but in equivocal cases the accurate diagnosis can only be made by microscopic features. Herein, we report a striking, isolated pigmented and inflamed SK, located on the waist in an elderly man. Read More

Dermatol Ther 2019 Apr 12:e12934. Epub 2019 Apr 12.

Department of Pathology, Istanbul Faculty of Medicine, Istanbul University.

Eye (Lond) 2019 Apr 11. Epub 2019 Apr 11.

Sligo University Hospital, Sligo, Ireland.

Aims: We report on the incidence of cutaneous eyelid tumours in Ireland over the 11-year-period from 2005 to 2015, we identify associations between demographic factors and cutaneous eyelid tumour risk.

Methods: Skin cancers, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), melanoma, and other cancers, located on the eyelid or canthus according to ICD-10 coding, as registered by the National Cancer Registry of Ireland (NCRI), were captured from the period 2005 to 2015. Age standardised rates (ASR) were calculated according to the European Standard Population (2013). Read More

J Dermatolog Treat 2019 Apr 11:1-17. Epub 2019 Apr 11.

a Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Sezione Fotoradioterapia , UO Dermatologia , Milan , Italy.

Background: Radiotherapy is a valuable therapeutic option for the treatment of non-melanoma skin cancer (NMSC) in the ageing population, in non-surgical candidates, or when the tumour is extensive or localised in a cosmetically-sensitive area such as the lips.

Objective: We report our 44-year experience in treating basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the vermilion lip using superficial radiotherapy.

Methods: Forty-seven patients with biopsy-proven BCC or SCC of the lip were retrospectively reviewed. Read More

Eur J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Skin and Venereal Diseases, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

J Eur Acad Dermatol Venereol 2019 Apr 11. Epub 2019 Apr 11.

CentroDerm GmbH, Heinz-Fangman-Straße 57, Wuppertal, Germany.

Background: Mutations in kinetochore gene KNSTRN accelerate the development of cutaneous squamous cell carcinoma (SCC) and may correlate with different histological classifications of actinic keratosis (AKs).

Objective: To determine KNSTRN gene mutation frequency in healthy skin (HS), actinically damaged skin (ADS), in AKs with different histomorphological gradings, and invasive SCCs.

Methods: All samples were histologically evaluated. Read More

Int J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Medical Research Division, UMAE Hospital de Pediatria CMNO, IMSS, Guadalajara, Jalisco, Mexico.

Introduction: Giant basal cell carcinoma (GBCC) is a tumor ≥5 cm in size, with aggressive biological behavior, that represents 1% of basal cell carcinomas (BCC), and studies regarding it are scarce. Our objective was to investigate the clinical-histopathological characteristics of GBCC and the risk factors associated with its development.

Methods: A retrospective study over 8 years included patients with the clinical and histopathological diagnosis of GBCC. Read More

Br J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Medical Genetics Department, School of Medicine, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, 14176-13151, Iran.

Basal Cell Carcinoma (BCC) is the most common malignancy among fair-skinned people. In contrast to other types of cancer, BCC has the lowest rate of metastasis and mortality. Although several molecular signaling pathways have been documented to play a role in BCC formation, the molecular mechanism to explain why BCC is distinctively rarely metastatic has not been elucidated yet. Read More

Indian J Dermatol Venereol Leprol 2019 Apr 11. Epub 2019 Apr 11.

Department of Pathology, Cancer Institute, Adyar (W.I.A.), Chennai, Tamil Nadu, India.

Basal cell carcinoma (BCC) is the most common malignant skin tumor which occurs more frequently over the sun exposed parts of body. Its adenoid variant is a rare histological subtype. We report a case of multiple adenoid basal cell carcinomas at unusual sites in a middle-aged male patient. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):354-356

Zunyi Medical University, Zunyi, 563000, China.

To explore the pathological types, distribution and characteristics of external nose skin tumors, in order to improve the diagnosis and treatment of such diseases, and provide reference for the clinical diagnosis and treatment of external nose skin tumors. The gender, age of onset, lesion location, lesion size, pathological type, course of disease and related risk factors of all 187 cases with external nose skin tumors in our hospital from January 2008 to December 2017 were analyzed retrospectively. The sex ratio of patients with external nasal skin benign tumors was 1. Read More

Dermatol Ther 2019 Apr 9:e12908. Epub 2019 Apr 9.

Dermatologic Unit, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.

Basal cell carcinomas are the most common non-melanoma skin cancers. Dermoscopy is an indispensable tool to differentiate superficial basal cell carcinoma from other subtypes and between pigmented and not pigmented ones. Although surgery is considered the gold-standard therapy, new current pharmacological options are available and focus on tumor eradication, increasing cosmetic results and functionality. Read More

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):115-121

Department of Oral and Maxillofacial Surgery, Haldia Institute of Dental Sciences and Research, West Bengal University of Health Sciences, Haldia, West Bengal, India.

Gorlin-Goltz syndrome (GGS) also known as the nevoid basal cell carcinoma syndrome or the nevus-Bifid rib syndrome is an inherited autosomal dominant syndrome. It is caused by genetic alteration produced by a mutation in the "patched" tumor suppressor gene. This rare syndrome is characterized by basal cell carcinoma of skin, multiple odontogenic keratocyst and bifid ribs along with other features such as hypertelorism, sex organ abnormalities, palmar and/or plantar pits and calcification of falx cerebri. Read More

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):58-62

Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.

Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor. Approximately 138 cases were reported. The majority of these cases occurred in the mandible. Read More

J Eur Acad Dermatol Venereol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology and Wound Healing, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.

The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient Oriented Outcomes, Melanoma and Non-Melanoma Skin Cancer (NMSC) present a review of the literature and position statement on health-related (HR) QoL assessment in skin cancer patients. A literature search was carried out to identify publications since 1980 that included information about the impact of SC on QoL. Generic, dermatology-specific, cancer-specific, SC-specific, facial SC-specific, NMSC-specific, basal cell carcinoma-specific and melanoma-specific QoL questionnaires have been used to assess HRQoL in SC patients. Read More

Nat Commun 2019 04 8;10(1):1600. Epub 2019 Apr 8.

Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 21, Solna, Sweden.

In the preceding decades, molecular characterization has revolutionized breast cancer (BC) research and therapeutic approaches. Presented herein, an unbiased analysis of breast tumor proteomes, inclusive of 9995 proteins quantified across all tumors, for the first time recapitulates BC subtypes. Additionally, poor-prognosis basal-like and luminal B tumors are further subdivided by immune component infiltration, suggesting the current classification is incomplete. Read More

Cell Biol Int 2019 Apr 8. Epub 2019 Apr 8.

State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, Xinjiang Uygur Autonomous Region, Urumqi, PR China.

KIAA1377 has been found to be linked with lymph node metastasis in esophageal squamous cell carcinoma in our previous study; however, the regulation of KIAA1377 remains far from understood. Herein, to understand the regulation of KIAA1377 from the angle of miRNA-mRNA modulation in the setting of squamous cell carcinoma (SCC) cells, basal level of KIAA1377 was determined by quantitative real-time PCR (qRT-PCR) and western-blot in KYSE-150 and HeLa cells; Biological roles of KIAA1377 contributed in the proliferation, migration and invasion were evaluated using MTT, wound-healing and Transwell assays, respectively after KIAA1377 was knocked out mediated by CRISPR-Cas9 system. Bioinformatic prediction revealed that let-7b-5p was a putative miRNA regulating KIAA1377, which was ensuingly validated by luciferase reporter assay; after which, variation of KIAA1377 expression was further verified by qRT-PCR and western-blot. Read More

J Am Acad Dermatol 2019 Apr 4. Epub 2019 Apr 4.

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy; Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Centro Oncologico ad Alta Tecnologia Diagnostica-Dermatologia, Reggio Emilia, Italy.

Background: Reflectance confocal microscopy (RCM)-based skin cancer diagnosis requires proficiency.

Aims: To identify a shortlist of key RCM features of skin cancers and test their diagnostic utility.

Methods: We identified key RCM features through consensus among six experts using a modified-Delphi method. Read More

Dent Med Probl 2019 Jan-Mar;56(1):105-110

Department of Oral Surgery, Faculty of Dentistry, Wrocław Medical University, Poland.

Basal cell carcinoma (BCC) is the most common skin cancer. It accounts for approx. 80% of human skin cancers and belongs to the group of non-melanoma skin cancers (NMSC). Read More

Cir Cir 2019 ;86(1):15-23

Dermatology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico City. Mexico.

Introduction: Surgery is performed more frequently now at days, due to the increasing incidence of melanoma and no-melanoma skin cancer. There are different opinions among dermatologic surgeons between to continue or discontinue antithrombotic therapy prior to the procedure, which increases the risk of thromboembolic events. Prophylaxis with oral antibiotics in the postsurgical period is controversial. Read More

Oncol Lett 2019 May 25;17(5):4112-4125. Epub 2019 Feb 25.

Department of Dermatology, 'Prof. N. Paulescu' National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania.

Basal cell carcinoma (BCC) is the most prevalent skin cancer in the Caucasian population. A variety of different phenotypic presentations of BCC are possible. Although BCCs rarely metastasize, these tumors commonly destroy underlying tissues and should therefore be treated promptly. Read More

Oncol Lett 2019 May 19;17(5):4068-4084. Epub 2018 Nov 19.

Department of Pathology, Colentina Clinical Hospital, 020125 Bucharest, Romania.

The extremely delicate shift from an inflammatory process to tumorigenesis is a field of major scientific interest. While the inflammation induced by environmental agents has well known underlying mechanisms, less is known concerning the oncogenic changes that follow an inflammatory chronic status in the tissue microenvironment that can lead to pro-tumorigenic processes. Regardless of the origin of the environmental factors, the maintenance of an inflammatory microenvironment is a clear condition that favors tumorigenesis. Read More

J Cosmet Dermatol 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, College of Medicine, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

Background: Imiquimod 5% cream is currently approved to treat several dermatologic conditions including actinic keratoses (AK), superficial basal cell carcinoma (sBCC), and genital warts. However, there are numerous studies published on the alternative off-label uses of imiquimod cream. Photoaging of facial skin is an important use for topical skin treatments, yet few studies have evaluated the effect of imiquimod cream for this dermatological condition. Read More

Dermatol Surg 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Dermatology 2019 Apr 2:1-6. Epub 2019 Apr 2.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland,

Background: Due to the importance of function and cosmetics, periocular skin malignancies represent a therapeutic challenge.

Objective: To evaluate the safety and efficacy of radiotherapy (RT) treating periocular skin tumors.

Methods: Data of patients with periocular tumors treated with grenz or soft X-rays at the University Hospital Zurich, Switzerland, between 2009 and 2014 were reviewed. Read More

Eur J Med Chem 2019 Jun 26;172:1-15. Epub 2019 Mar 26.

Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 215123, PR China. Electronic address:

The Hedgehog (Hh) pathway plays a critical role during embryonic development by controlling cell patterning, growth and migration. In adults, the function of Hh pathway is curtailed to tissue repair and maintenance. Aberrant reactivation of Hh signaling has been linked to tumorigenesis in various cancers, such as basal cell carcinoma (BCC) and medulloblastoma. Read More

J Clin Med Res 2019 Apr 18;11(4):247-255. Epub 2019 Mar 18.

Department of Cardiovascular Sciences, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

Background: Thiazide diuretics are among the most widely prescribed antihypertensive agents. Given their photosensitizing effects, however, there are concerns that they may increase the risk of skin cancers. In this meta-analysis, we investigated an association between the use of thiazide diuretics and the risk of skin cancers. Read More

Exp Ther Med 2019 Apr 12;17(4):2746-2756. Epub 2019 Feb 12.

Department of Dermatology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518100, P.R. China.

Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) have exhibited a marked increase in incidence in previous decades and are the most common malignancies in Caucasian populations. Src homology 3 and multiple ankyrin repeat domains protein-associated RH domain-interacting protein (SHARPIN) has been identified as a commonly overexpressed proto-oncogene in several types of visceral cancer. However, to the best of our knowledge, the functions of SHARPIN in nonmelanoma skin cancer (NMSC) have not been described. Read More