Cancer Discov 2017 Sep 15. Epub 2017 Sep 15.

Coding or enhancer mutations in ACTRT1 reduce its expression to drive basal cell carcinoma. Read More

Oncotarget 2017 Aug 18;8(34):57707-57722. Epub 2017 Apr 18.

Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Autophagy is an evolutionarily conserved lysosome-dependent catabolic process which degrades cell's components in order to recycle substrates to exert optimally and adapt to tough circumstances. It is a critical cellular homeostatic mechanism with stress resistance, immunity, antiaging, and pro-tumor or anti-tumor effects. Among these, the role of autophagy in cancer is the most eye-catching that is not immutable but dynamic and highly complex. Read More

APMIS 2017 Sep 15. Epub 2017 Sep 15.

Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.

To evaluate the clinicopathological characteristics, high-risk lifestyle factors (HRLF: chronic exposure to sun, betel quid, alcohol, and tobacco), and prognostic factors of lip cancer. The hospital records of patients with pathologically confirmed lip squamous cell carcinoma (LSCC, n = 112) and lip basal cell carcinoma (LBCC, n = 21) were reviewed. Differences in clinicopathological characteristics between LSCC and LBCC, upper and lower lip, and status of second primary tumors were compared by chi-square test and logistic regression. Read More

Arch Craniofac Surg 2017 Jun 26;18(2):141-144. Epub 2017 Jun 26.

Department of Plastic and Reconstructive Surgery, Institute of Health Sciences, College of Medicine and Hospital, Gyeongsang National University, Jinju, Korea.

An odontogenic cutaneous fistula is a pathological communication between the outer skin surface of the face and the oral cavity. Facial cutaneous fistula is a complication of odontogenic infection that is often misdiagnosed with skin infection. We report a rare case, which was diagnosed as basal cell carcinoma based on the biopsy of skin lesions in the patient who had been diagnosed with odontogenic cutaneous fistula. Read More

Arch Craniofac Surg 2017 Mar 25;18(1):46-49. Epub 2017 Mar 25.

Department of Pathology, Busan-Baik Hospital, Inje University School of Medicine, Busan, Korea.

Nevus sebaceus is a hamartoma of the sebaceous gland that occurs congenitally, from which various secondary tumors can arise with a prevalence of 5%-6%. Benign neoplasms commonly arise from nevus sebaceous, but they have a very low malignant potential. Two neoplasms may occasionally arise within the same lesion, but it is rare for three or more neoplasms to occur in a nevus sebaceus simultaneously. Read More

Arch Craniofac Surg 2017 Mar 25;18(1):44-45. Epub 2017 Mar 25.

Department of Plastic and Reconstructive Surgery, Dongguk University College of Medicine, Gyeongju, Korea.

Eccrine poroma is a common benign cutaneous tumor that originates in an intraepidermal eccrine duct. This tumor exhibits acral distribution (sole, palm), and is rarely encountered in the head and neck area. In fact eccrine poroma in the postauricular area has only been rarely reported. Read More

Arch Craniofac Surg 2017 Mar 25;18(1):37-43. Epub 2017 Mar 25.

Department of Plastic and Reconstructive Surgery, Konyang Hospital, Konyang University School of Medicine, Daejeon, Korea.

Background: Skin cancer is the most common type of cancer. Of the 4 million skin lesions excised annually worldwide, approximately 2 million are considered cancerous. In this study, we aimed to describe a regional experience with skin cancers treated by a single senior surgeon and to provide a treatment algorithm. Read More

Hautarzt 2017 Sep 13. Epub 2017 Sep 13.

Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Klinikum rechts der Isar, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland.

Background: Teledermoscopy is a promising modern technique to complement or to substitute dermatologic examination.

Objective: In this pilot study, we compared the outcomes of teledermoscopic consultations with clinical examinations and histologic results.

Methods: Conventional and dermatoscopic photos of single lesions were taken in 26 patients using a mobile phone and an attached handyscope optical system. Read More

J Cutan Med Surg 2017 May/Jun;21(3):270-271

Dermatol Surg 2017 Sep 4. Epub 2017 Sep 4.

Department of Dermatology, University of Texas Medical Branch, Galveston, Texas.

Sci Rep 2017 Sep 12;7(1):11249. Epub 2017 Sep 12.

Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, CH-8091, Zurich, Switzerland.

Cells spontaneously emit photons in the UV to visible/near-infrared range (ultra-weak photon emission, UPE). Perturbations of the cells' state cause changes in UPE (evoked UPE). The aim of the present study was to analyze the evoked UPE dynamics of cells caused by two types of cell perturbations (stressors): (i) a cell culture medium change, and (ii) application of the pro-inflammatory cytokine tumor necrosis factor alpha (TNF-α). Read More

Klin Monbl Augenheilkd 2017 Sep 12. Epub 2017 Sep 12.

Zentrum für Augenheilkunde, Universitätsklinikum Essen, Essen.

This article is a review of diagnostic and therapeutic possibilities in common epibulbar malignant tumors, such as basal cell carcinoma, conjunctival lymphoma, squamous cell carcinoma and conjunctival melanoma. Most importantly, for every tumor patient there is a detailed anamnesis, split lamp examination and photo documentation. Further regular controls after therapy are required due to the risk of recurrences. Read More

J Dtsch Dermatol Ges 2017 Sep 12. Epub 2017 Sep 12.

Department of Dermatology, Lübeck University, Lübeck, Germany.

J Eur Acad Dermatol Venereol 2017 Sep 12. Epub 2017 Sep 12.

Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background: Skin cancer patients are primarily at increased risk of developing subsequent skin cancers of the same type. Shared risk factors might also increase the occurrence of a different type of subsequent skin cancer.

Objective: To investigate risks of different skin tumor combinations after a first melanoma, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Read More

Cancers (Basel) 2017 Sep 12;9(9). Epub 2017 Sep 12.

Harvard Medical School, Boston, MA 02115, USA.

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that has been implicated in the pathogenesis of a variety of neoplasms. As suggested by its name, ALK was first described as part of a translocation product in cases of anaplastic large-cell lymphoma, with other genetic and cytogenetic ALK mutations subsequently coming to attention in the development of many other hematologic and solid organ malignancies. ALK has now been shown to play a role in the pathogenesis of several cutaneous malignancies, including secondary cutaneous systemic anaplastic large-cell lymphoma (ALCL) and primary cutaneous ALCL, melanoma, spitzoid tumors, epithelioid fibrous histiocytoma, Merkel cell carcinoma, and basal cell carcinoma. Read More

Iran J Public Health 2017 Aug;46(8):1104-1109

Dept. of Clinical Biochemistry, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Background: Basal Cell Carcinoma (BCC) is one of the most common skin cancers in the world and that use to lifestyle, increasing chemical pollutions, environmental factors and poor nutrition. The most important cause of this cancer is oxidative stress and free radicals so antioxidant activities for the body are so important. The aim of this study was to determine the variation of zinc and (Malondialdehyde) MDA in BCC patients. Read More

J Clin Diagn Res 2017 Jul 1;11(7):XD06-XD08. Epub 2017 Jul 1.

Faculty, Department of Medical Oncology, Fondazione Istituto Nazionale dei Tumori, Milan, Italy.

The most frequently reported skin tumours during treatment with targeted therapies for BRAF (B type Rapidly Accelerated Fibrosarcoma kinase) mutated metastatic melanoma are squamous cell carcinomas (SCCs). Basal cell carcinomas (BCCs) have been described in such setting, but no cases of multiple and recurring tumours have been reported so far. A patient with a history of chronic sun exposure and more than 10 BCCs removed since 1998 started treatment with vemurafenib for BRAF mutated metastatic melanoma. Read More

J Clin Diagn Res 2017 Jul 1;11(7):MD09-MD10. Epub 2017 Jul 1.

Junior Resident, Department of Ear, Nose and Throat, Sri Siddhartha Medical College, Agalakote, Karnataka, India.

Nevus sebaceus of Jadassohn is a congenital tumour affecting the scalp and face. It is usually presented as a pigmented patch or plaque. It is a complex cutaneous hamartoma which involves pilosebaceous follicle, epidermis and adnexal structures. Read More

Arch Oral Biol 2017 Sep 2;83:340-347. Epub 2017 Sep 2.

Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.

Background: The purpose of this study was to investigate a difference in glycogen metabolism (glycogen synthesis and glycolysis) between the iodine stained (normal non-keartinized) and the unstained (dysplasctic/malignant) oral epithelium.

Methods: Twenty-one frozen tissue samples of iodine-stained and unstained mucosal tissue were obtained from 21 OSCC patients. Serial frozen sections were cut and examined with the hematoxylin-eosin and periodic acid-Schiff methods and immunohistochemical (IHC) staining for Ki67, P53, molecules associated with glycogenesis (i. Read More

Methods Mol Biol 2018 ;1655:121-136

Solid Tumour Target Discovery Laboratory, Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK.

Cancer stem cells are defined as a self-renewing and self-protecting subpopulation of cancer cells able to differentiate into morphologically and functionally diverse cancer cells with a limited lifespan. To purify cancer stem cells, two basic approaches can be applied, the marker-based approach employing various more of less-specific cell surface marker molecules and a marker-free approach largely based on various self-protection mechanisms. Within the context of urothelial carcinoma, both methods could find use. Read More

Methods Mol Biol 2018 ;1655:53-64

Division of Urological Research, Department of Translational Medicine, Lund University, Box 117, SE-221 00, Lund, Sweden.

Molecular subtypes of bladder cancer (BC) can be determined by relatively small immunohistochemistry panels both for non-muscle invasive (NMI) and muscle invasive (MI) tumors. For analysis of NMI tumors, as few as two markers are needed, although classification is dependent also on pathological grade and histological evaluation. The result is a classification into the three tumor-cell phenotypes of NMI-BC, Urothelial-like (Uro), Genomically Unstable (GU), and Basal/SCC-like. Read More

Am J Clin Dermatol 2017 Sep 8. Epub 2017 Sep 8.

Department of Dermatology, University of Colorado School of Medicine, Mail Stop F703, 1665, North Aurora Court, Aurora, CO, 80045, USA.

Basal cell carcinoma (BCC) is the most common type of skin cancer, with rising incidence rates primarily attributed to an aging population and ultraviolet radiation exposure. While the majority of BCCs are localized and respond to standard therapies, a very small minority of these tumors become locally destructive or metastasize. These advanced BCCs may not be amenable to localized treatment with surgery and/or radiation therapy. Read More

Sci Rep 2017 Sep 8;7(1):11023. Epub 2017 Sep 8.

Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine, University of Dundee, Dundee, DD1 9SY, Scotland, UK.

Autophagy plays a critical role in the maintenance of cellular homeostasis by degrading proteins, lipids and organelles. Autophagy is activated in response to stress, but its regulation in the context of other stress response pathways, such as those mediated by heat shock factor 1 (HSF1) and nuclear factor-erythroid 2 p45-related factor 2 (NRF2), is not well understood. We found that the Michael acceptor bis(2-hydoxybenzylidene)acetone (HBB2), a dual activator of NRF2 and HSF1, protects against the development of UV irradiation-mediated cutaneous squamous cell carcinoma in mice. Read More

Genes Dev 2017 Aug 8;31(15):1573-1587. Epub 2017 Sep 8.

Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada.

Epithelial cancers (carcinoma) account for 80%-90% of all cancers. The development of carcinoma is associated with disrupted epithelial organization and solid ductal structures. The mechanisms underlying the morphological development of carcinoma are poorly understood, but it is thought that loss of cell polarity is an early event. Read More

Dermatol Clin 2017 Oct 7;35(4):489-493. Epub 2017 Aug 7.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 275 York Avenue, New York, NY 10065, USA.

Electrical impedance spectroscopy (EIS) is a noninvasive method that aims to help diagnose skin cancer. The EIS device consists of a handheld probe with a disposable electrode that is applied directly on the skin and uses electrical impendence differences to differentiate between normal and abnormal skin lesions. The EIS algorithm is best used on lesions that are deemed clinically or dermoscopically suspicious and has a high sensitivity in detecting malignant melanoma. Read More

Br J Dermatol 2017 Sep 8. Epub 2017 Sep 8.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10022, USA.

Detecting basal cell carcinomas (BCCs) early and at relatively small sizes may expand therapeutic choices and enable less invasive treatment options. To this end, dermoscopy is a useful tool to diagnose BCC at early stages with high sensitivity and specificity.(1) Superficial BCCs have been shown to be independently associated with location on the trunk and extremities and nodular BCCs have been independently associated with a head/neck location. Read More

Br J Dermatol 2017 Sep 8. Epub 2017 Sep 8.

Department of Dermatology, Maastricht University Medical Centre, Maastricht, the Netherlands.

Background: Basal cell carcinoma (BCC) is the most common type of skin cancer with growing incidence rates. Photodynamic therapy (PDT) is a frequently used treatment, especially for superficial BCC (sBCC). Two topical photosensitizing agents are currently used to treat sBCC: 5-aminolevulinic acid (ALA) and its methyl-ester (MAL). Read More

J Craniofac Surg 2017 Sep 6. Epub 2017 Sep 6.

*Head and Neck Departement, University of Naples Federico II, Naples †Neurosurgery Departement, University of Salerno, Salerno, Italy.

Purpose: The aim of this study was to report management and outcomes in patients affected by eyelids carcinomas involving regional lymph nodes.

Methods: We have retrospectively analyzed the data of patients affected by eyelids carcinoma with nodal involvement. The clinical records of 10 patients with malignant eyelid carcinoma and regional nodal metastasis treated between September 2011 and March 2015 have been analyzed. Read More

J Clin Neurol 2017 Sep 4. Epub 2017 Sep 4.

Department of Surgical Sciences and Advanced Technologies, Section of Neurosciences, Azienda Ospedaliero Universitaria "Policlinico-Vittorio Emanuele", Catania, Italy.

Lasers Med Sci 2017 Sep 7. Epub 2017 Sep 7.

University of Wales Trinity Saint David, Swansea, SA1 6ED, UK.

The development and use of light and lasers for medical and cosmetic procedures has increased exponentially over the past decade. This review article focuses on the incidence of reported cases of skin cancer post laser or IPL treatment. The existing evidence base of over 25 years of laser and IPL use to date has not raised any concerns regarding its long-term safety with only a few anecdotal cases of melanoma post treatment over two decades of use; therefore, there is no evidence to suggest that there is a credible cancer risk. Read More

Oncotarget 2017 Aug 18;8(32):53873-53885. Epub 2017 Apr 18.

Department of General Surgery, Bailou Hospital, Tianjin 300040, PR China.

Tumor necrosis factor-alpha (TNF-α) is a multifunctional pro-inflammatory cytokine that plays an important role in cancer development. We performed a meta-analysis to assess the relationship between single nucleotide polymorphisms in the TNF-α promoter region (rs1800629 and rs361525) and susceptibility to squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and melanoma. After database retrieval, article selection, data extraction, and quality assessment, 20 articles comprising 4865 cases and 6329 controls were included in this study. Read More

JAMA Facial Plast Surg 2017 Sep 7. Epub 2017 Sep 7.

University of Virginia School of Medicine, Charlottesville.

Importance: Same-day Mohs reconstructive surgery is not always possible; moreover, a delay can offer benefits such as improved surgical planning and increased blood supply to the cauterized wound bed. However, recent work found that delaying reconstruction by more than 2 days increases the postoperative complication rate.

Objective: To review the outcomes of Mohs micrographic surgery (MMS) reconstruction with respect to patient- and surgery-specific variables, especially timing of repair. Read More

Clin Case Rep 2017 Sep 1;5(9):1550-1551. Epub 2017 Aug 1.

Surgery DepartmentIstituti Clinici ZucchiUniversity of Milano-BicoccaMonzaItaly.

This clinical image shows the importance of the early diagnosis and treatment of any suspicious skin lesion. Read More

Appl Immunohistochem Mol Morphol 2017 Sep 4. Epub 2017 Sep 4.

Department of Pathology and Laboratory Medicine, The Ottawa Hospital and University of Ottawa, ON, Canada.

Background: Invasive cervical cell squamous carcinoma (ICC) classically develops from high grade cervical intraepithelial neoplasia of usual type (uCIN). Differentiated cervical intraepithelial neoplasia (dCIN) analogue to differentiated vulvar intraepithelial neoplasia has not been described in the cervix.

Methods: A pilot case of ICC developing from dCIN with atypia limited to the basal/parabasal layers, focally associated with neoplastic spread above the parabasal layer (usual-like CIN pattern or u-like CIN) was identified. Read More

Ugeskr Laeger 2017 Aug;179(35)

Basal cell carcinoma (BCC) have many treatment options either by dermatologist, with excision or radiotherapy. A 78-year-old woman had a BCC removed surgically, and 18 years after she had a subcutaneously located tumour extirpated at the same location. The result of pathological examination was BCC located atypically in the subcutis. Read More

J Cutan Pathol 2017 Sep 5. Epub 2017 Sep 5.

Department of Pathology, University of South Dakota, Sanford School of Medicine, Sioux Falls, South Dakota.

Background: Reliable nuclear immunohistochemical stains for sebaceous neoplasms have not been readily available. Positive nuclear staining has been reported by GATA3 and factor XIIIa (AC-1A1). We sought to determine the diagnostic utility of these nuclear stains by comparing their staining pattern to adipophilin, a consistently positive cytoplasmic stain. Read More

Nat Med 2017 Sep 4. Epub 2017 Sep 4.

Paris Descartes University, Sorbonne Paris Cité, Paris, France.

Basal cell carcinoma (BCC), the most common human cancer, results from aberrant activation of the Hedgehog signaling pathway. Although most cases of BCC are sporadic, some forms are inherited, such as Bazex-Dupré-Christol syndrome (BDCS)-a cancer-prone genodermatosis with an X-linked, dominant inheritance pattern. We have identified mutations in the ACTRT1 gene, which encodes actin-related protein T1 (ARP-T1), in two of the six families with BDCS that were examined in this study. Read More

Oncogenesis 2017 Sep 4;6(9):e376. Epub 2017 Sep 4.

Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.

Human chorionic gonadotropin β (β-hCG) has been implicated in breast tumorigenesis. However, the role of this hormone is highly controversial as certain studies suggest it has anti-tumor properties while others have found it to be pro-tumorigenic. To unveil the truth, we have analyzed the expression of β-hCG in breast cancer. Read More

Adv Exp Med Biol 2017 ;1006:313-328

Department of Dermatology, Vivantes Klinikum im Friedrichshain, Landsberger Allee 49, 10249, Berlin, Germany.

Adhesion, segregation, and cellular plasticity are regulated by actin filaments anchored at the plaques of adherens junctions, sites of mechanical stabilization, and interfaces of multiple signaling networks. Drebrins were originally identified in neuronal cells, but the isoform drebrin E was also detected at adherens junctions of a wide range of non-neuronal cells, including polarized epithelia, endothelia, and fibroblasts. Here the protein is enriched at actin filament bundles associated with junctional plaques. Read More

J Cancer Res Ther 2017 Jul-Sep;13(3):484-486

Department of Pathology, Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Context: The eyelids are affected by wide spectrum of benign and malignant lesions. Basal cell carcinoma (BCC) is the most common malignancy encountered while other malignant lesions such as sebaceous cell carcinoma and squamous cell carcinoma are rare. Data regarding geographical variation in trends of malignant eyelid tumors are presented in the current study. Read More

Eur J Dermatol 2017 Aug;27(4):386-392

Hôpital de la Timone, Marseille, France.

Understanding the molecular basis of basal cell carcinoma (BCC) has led to development of Hedgehog pathway inhibitors (HPIs) for patients with advanced forms of BCC (aBCC). A practical definition of aBCC as a distinct disease entity is unavailable, and epidemiological information is limited. To conduct the RONNIE study to describe characteristics, treatment patterns, and outcomes of patients with aBCC during the period preceding HPI introduction, as well as results from patients with locally advanced BCC (laBCC). Read More

Saudi J Ophthalmol 2017 Jul-Sep;31(3):183-185. Epub 2017 May 17.

New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, United States.

Trichilemmal carcinomas are rare malignant adnexal tumors which can involve the head and, rarely, the eyelid. Accurate diagnosis and differentiation from basal cell carcinoma or trichoepithelioma are dependent on histopathological and immunohistochemical analysis. We report a case of an eyelid mass, initially diagnosed by incisional biopsy as a trichoepithelioma, later found on excisional biopsy to be a trichilemmal carcinoma and present a review of the literature of the histopathology, differential diagnosis and management. Read More

Skinmed 2017 1;15(4):307-308. Epub 2017 Aug 1.

Department of Dermatology at the University of Virginia School of Medicine, Charlottesville, VA.

A 74-year-old Caucasian man with poorly controlled diabetes and hypertension was seen in the dermatology clinic for treatment of a nodular basal cell carcinoma on his right temple. He had poorly controlled diabetes for decades and had been insulin dependent for 20 to 25 years. He had not been on any anticoagulation therapy in the past or present and had no history of a hematologic disorder. Read More

Skinmed 2017 1;15(4):265-268. Epub 2017 Aug 1.

Section of Dermatology, The University of Chicago Pritzker School of Medicine, Chicago, IL;

There are many molecular variations in the histologic subtypes of basal cell carcinoma (BCC); Ki67 and Bcl-2 expression differs among them and might relate to their prognostic features. The clinically notable friability and its histologic counterpart, retraction, are dependent on cell-cell adhesion and basement membrane characteristics, which may be altered in different ways depending on the tumor morphology and phenotype. Finally, we discuss the pathogenesis of BCCs and recent molecular advances with a review of new and upcoming molecular-based therapeutics. Read More

Dermatol Surg 2017 Aug 29. Epub 2017 Aug 29.

Surgical Dermatology Group, Birmingham, Alabama.

Background: Nonmelanoma skin cancers (NMSCs) of the ear are considered high risk. Precise location of tumor sites is important when identifying surgical treatment sites.

Objective: Review precise locations and histopathologic subtypes of auricular NMSC treated with Mohs micrographic surgery (MMS) using a standardized topographical numbering system for rapid data extraction. Read More

Dermatol Surg 2017 Aug 30. Epub 2017 Aug 30.

Departments of *Dermatology, and †Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; ‡Department of Dermatology, University of California, San Francisco, San Francisco, California.

Background: Mohs surgery (MS) is regarded as one of the most efficient surgical procedures for the treatment of skin tumors.

Objectives: Delineating tumor margins accurately is important in limiting broad excisions during conventional surgery and in reducing the number of stages during Mohs procedure.

Methods: This study aimed to evaluate the role of 2 simple procedures, curettage and videodermoscopy (VDS), in determining margins during MS for the treatment of basal cell carcinoma (BCC) of the head and neck. Read More

Am J Dermatopathol 2017 Oct;39(10):742-746

*Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany; and †Labor für Dermatohistologie, Munich, Germany.

Background: As important players of the innate immune system, Toll-like receptors (TLRs) and their role for tumorigenesis have been in the focus of research. In particular TLR7 is an interesting candidate, as TLR7 agonists are broadly used for the treatment of cutaneous tumors. However, data addressing the baseline expression of TLR7 in both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) on the protein level are lacking, while on the genomic level significantly elevated expression of TLR7 in SCC but not in BCC has been demonstrated. Read More

Dermatol Surg 2017 Aug 28. Epub 2017 Aug 28.

Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Center (AMC), Amsterdam, the Netherlands Department of Pathology, Academic Medical Center (AMC), Amsterdam, the Netherlands Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Center (AMC), Amsterdam, the Netherlands, Onze lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Center (AMC), Amsterdam, the Netherlands.

Biomed Opt Express 2017 Aug 24;8(8):3807-3815. Epub 2017 Jul 24.

Ronald O. Pearleman Department of Dermatology, New York University, 240 E. 38th St., New York, NY 10016, USA.

For rapid pathological assessment of large surgical tissue excisions with cellular resolution, we present a line scanning, stage scanning confocal microscope (LSSSCM). LSSSCM uses no scanning mirrors. Laser light is focused with a single cylindrical lens to a line of diffraction-limited width directly into the (Z) sample focal plane, which is parallel to and near the flattened specimen surface. Read More

Cancer Cell Int 2017 24;17:77. Epub 2017 Aug 24.

Institute of Physiology, Center for Structural and Cell Biology in Medicine, University of Luebeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.

Background: The transcription factor aryl hydrocarbon receptor nuclear translocator (ARNT) participates in the hypoxia-inducible factor (HIF) pathway which senses a decline in cellular oxygen tension. In hypoxia, HIF-1α and ARNT form the transcriptional active complex HIF-1 followed by the expression of target genes. ARNT is considered as constitutively expressed and unaffected by hypoxia. Read More