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    Carcinoma ex basal cell adenoma of the parotid gland: A report of an extremely rare case.
    Pathol Int 2017 May 19. Epub 2017 May 19.
    Pathology Division, Shizuoka Cancer Center, Shizuoka 411-8777, Japan.
    Malignant non-basaloid tumors that arise from basal cell adenoma (BCA) are extremely rare. The patient was a 72-year-old Japanese male, who had noticed swelling of the left parotid region 21 years ago. A superficial lobectomy was performed. Read More

    Multiple skin cancers in patients with mycosis fungoides after long-term ultraviolet phototherapy.
    Clin Exp Dermatol 2017 May 22. Epub 2017 May 22.
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Phototherapy is a useful noninvasive therapy, but it can induce cutaneous malignant tumours, including squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). We report on a 79-year-old man who had long-standing mycosis fungoides for 40 years, which had been treated with psoralen ultraviolet A therapy for 37 years at a dose of approximately 5000 J/cm(2) . Approximately 6 years before presentation, numerous types of cutaneous malignancies, including actinic keratosis, BCC and SCC, had begun to develop all over the patient's body. Read More

    Intraepidermal Merkel cell carcinoma: a case series of a rare entity with clinical follow-up.
    J Cutan Pathol 2017 May 23. Epub 2017 May 23.
    Department of Pathology, Dermatopathology Section, The University of Texas MD, Anderson Cancer Center, Houston, TX, USA.
    Background: Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous carcinoma. MCC involves typically dermis and although epidermotropism has been reported, MCC strictly intraepidermal or in situ (MCCIS) is exceedingly rare. Most of the cases of MCCIS described so far have associated other lesions, such as squamous or basal cell carcinoma, actinic keratosis, etc. Read More

    Evaluation of surgical margins according to the histological type of basal cell carcinoma.
    An Bras Dermatol 2017 Mar-Apr;92(2):226-230
    Department of Dermatology, University Hospital of the Federal University of Sergipe (HU-UFS), Aracaju, SE, Brazil.
    Basal cell carcinoma is the most common skin cancer in the world. The aim of this study was to evaluate the surgical margin of basal cell carcinoma and correlate this with its histologic subtype. A retrospective analysis of pathology laboratory records from 1990 to 2000 was performed and the following data was collected: age, sex, race, anatomical location, histological type, and state of the excision margins in 1,428 histopathological reports of basal cell carcinoma. Read More

    Unnecessary Cost of Post-Mohs Permanent Pathology.
    Dermatol Surg 2017 May 22. Epub 2017 May 22.
    *Department of Dermatology, Johns Hopkins University, Baltimore, Maryland;†Laser and Dermatologic Surgery Center, Chesterfield, Missouri.
    Background: By providing tumor-free margins, Mohs micrographic surgery (MMS) results in high cure rates in the treatment of nonmelanoma skin cancers (NMSCs). However, when closure of the post-MMS defect is coordinated with reconstructive surgery, redundant tissue is sometimes submitted for permanent section evaluation.

    Objective: The purpose of our study was to investigate the frequency and effect of this practice. Read More

    Basaloid follicular hamartoma: clinical, dermoscopic, and histopathological characteristics of case.
    Dermatol Online J 2017 May 15;23(5). Epub 2017 May 15.
    Division of Dermatology, Department of Medicine, National University Hospital, Singapore. ellie_
    Basaloid follicular hamartoma (BFH) is a rare benign adnexal tumor with variable clinical presentation. We report a case of a 64-year-old man, who presented with an incidental finding of a 3mm hyperpigmented macule on his cheek. Dermoscopy revealed a structureless blue lesion. Read More

    Can the onset of orbital cancer be the result of a prosthetic eye?
    Acta Otorhinolaryngol Ital 2017 May 22. Epub 2017 May 22.
    ENT Department, University "G. d'Annunzio" of Chieti-Pescara, Hospital "SS Annunziata",Chieti, Italy.
    Orbital exenteration is a disfiguring procedure performed for unresponsive orbital infections and control of recurrent benign tumours and malignancies arising from the eyelids (basal cell carcinoma, squamous cell carcinoma, conjunctival malignant melanoma), lachrymal glands (adenoid cystic carcinoma) or surrounding sinuses. In extremely rare cases the use of a prosthetic eye after enucleation can lead to anophthalmic socket tumours. We report the case of a 54-year-old man who had left eye enucleation due to recurring events of retinal detachment and who developed an invasive fast growing epidermoid carcinoma 30 years later. Read More

    Snail homolog 1 is involved in epithelial-mesenchymal transition-like processes in human glioblastoma cells.
    Oncol Lett 2017 May 17;13(5):3882-3888. Epub 2017 Mar 17.
    Department of Pediatrics, University Clinic and Polyclinic for Child and Adolescent Medicine I, Martin Luther University Halle-Wittenberg, D-06120 Halle, Germany.
    Despite advancements in neurosurgery, chemotherapy and radiation therapy, the outcome of patients with glioblastoma remains poor. The migration of tumor cells from the primary tumor site with subsequent invasion of these cells into the surrounding normal brain tissue is frequently responsible for relapse and treatment failure. The present study hypothesized that snail homolog 1 (SNAI1), a factor critically involved in the epithelial-mesenchymal transition (EMT) of human carcinoma cells, may also contribute to an invasive EMT-like phenotype of glioblastoma cells. Read More

    A Multicenter Clinical Study of Expected and Unexpected Side Reactions During and After Skin Cancer Treatment by Photodynamic Therapy.
    Skinmed 2017 1;15(2):113-118. Epub 2017 Apr 1.
    University of São Paulo, São Carlos Institute of Physics, São Carlos, São Paulo, Brazil.
    Photodynamic therapy (PDT) has been widely used for oncologic indications, especially nonmelanoma skin cancer such as superficial and nodular basal cell carcinoma (BCC). We present a multicenter clinical study conducted between 2012 and 2014 analyzing the adverse reactions during and after PDT with a standardized protocol in 866 lesions. A total of 728 patients with positive clinical and histopathological diagnosis for BCC with up to 2 cm diameter were treated. Read More

    Epithelial Mesenchymal Transition (EMT) in Metastatic Breast Cancer in Omani Women.
    Cancer Microenviron 2017 May 19. Epub 2017 May 19.
    College of Medicine, Sultan Qaboos University, Muscat, Oman.
    Breast cancer (BC) in Oman affects younger women and has a more aggressive course. Clinical and biological variables like age, pregnancy, tumor size, type, grade, receptor expression and proliferation predict disease aggression but there is no direct predictor of metastasis except lymphovascular invasion. Epithelial-mesenchymal transition (EMT) is characterized by epithelial cells losing epithelial and acquiring mesenchymal morpho-immunophenotypic characteristics. Read More

    Atypical presentations of cutaneous leishmaniasis: A systematic review.
    Acta Trop 2017 May 17;172:240-254. Epub 2017 May 17.
    Laboratory of Microbiology and Parasitology, Faculty of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil. Electronic address:
    Cutaneous Leishmaniasis (CL) is endemic in 88 countries, showing relevant prevalences. The aim of this study was to perform a systematic review on atypical lesions of CL around the world, addressing clinico-epidemiological, immunological and therapeutic aspects. A search of the literature was conducted via electronic databases Scopus and PubMed for articles published between 2010 and 2015. Read More

    Genetic diseases associated with an increased risk of skin cancer development in childhood.
    Curr Opin Pediatr 2017 May 18. Epub 2017 May 18.
    aStanford University School of Medicine bDepartment of Dermatology cDepartment of Dermatology and Pediatrics dDivision of Pediatric Dermatology, Stanford University School of Medicine, USA.
    Purpose Of Review: Childhood skin cancers are relatively rare and may indicate an underlying genetic disorder. The increasing elucidation of genetic pathways is changing the diagnosis and management of genetic skin cancer susceptibility syndromes. In this review, we provide an overview of genetic conditions that predispose to skin cancer development in childhood and signs that providers should assess when evaluating affected individuals. Read More

    An immunohistochemical analysis of lymphocytic infiltrations in canine skin cancers.
    Pol J Vet Sci 2017 Mar;20(1):141-147
    Lymphocytic infiltrations located in the extracellular matrix often accompany canine skin cancer. They can be characterised as an inflammatory infiltration and/or a second tumour - lymphoma. The aim of this study was an immunohistochemical analysis of a lymphocytic infiltration which accompanies spontaneous skin cancer. Read More

    Risk factors associated with relapse of eyelid basal cell carcinoma: results from a retrospective study of 142 patients.
    Eur J Dermatol 2017 May 19. Epub 2017 May 19.
    LTTA Centre, University of Ferrara, Ferrara, Italy, Department of Morphology, Surgery and Experimental Medicine, Anatomy and Histology Section, University of Ferrara, Ferrara, Italy.
    Of skin cancers, 9% arise at the periocular level, constituting a significant threat due to the proximity to intracranial structures, such as the eyes, nerve endings and proximal tissues. Tumour recurrence can be frequent and represents a primary clinical challenge for the surgeon. To present a retrospective study on the treatment of eyelid tumours at a tertiary care centre in Italy over an eight-year period and, in particular, to underline the risk factors associated with tumour relapse. Read More

    Pharmacokinetics and safety of vismodegib in patients with advanced solid malignancies and hepatic impairment.
    Cancer Chemother Pharmacol 2017 May 18. Epub 2017 May 18.
    Genentech, Inc., South San Francisco, CA, USA.
    Purpose: Vismodegib is a Hedgehog pathway inhibitor approved for the treatment of advanced basal cell carcinoma. Currently, the pharmacokinetics (PK) and safety of vismodegib in patients with hepatic dysfunction are unknown and are the objective of this study.

    Methods: Patients with advanced solid malignancies and hepatic impairment were enrolled into one of four cohorts: normal [bilirubin (bili) < upper limit of normal (ULN)], mild (ULN < bili ≤ 1. Read More

    Incidence and Trends of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma: A Population-Based Study in Olmsted County, Minnesota, 2000 to 2010.
    Mayo Clin Proc 2017 May 10. Epub 2017 May 10.
    Department of Dermatology, Mayo Clinic, Rochester, MN. Electronic address:
    Objective: To determine population-based incidence estimates of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC).

    Patients And Methods: We reviewed the medical records of a population-based cohort diagnosed with nonmelanoma skin cancer between January 2, 2000, and December 31, 2010. The age- and sex-adjusted incidence rates were calculated and compared with estimates from previous periods. Read More

    [The aged scalp : A dermato-oncological focus point].
    Hautarzt 2017 May 17. Epub 2017 May 17.
    Hauttumorcentrum, Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
    Non-melanoma skin cancer and its precursor lesions are common diagnoses in dermatological practice, due to rising incidence and prevalence. Diagnosis is often clinical with subsequent histological confirmation. First-choice treatment for invasive carcinomas is complete surgical excision. Read More

    Primary myxoid melanoma with dermoscopic findings.
    Dermatol Pract Concept 2017 Apr 30;7(2):59-61. Epub 2017 Apr 30.
    Department of Dermatology, Istanbul Medeniyet University, Goztepe Research and Training Hospital, Istanbul, Turkey.
    Myxoid melanoma is a rare variant of melanoma, which is characterized by atypical spindle cells and dense mucin deposition in dermis. This tumor is usually seen in elderly people with a similar progress in other variants of melanoma. A 28-year-old male presented to our outpatient clinic with a 6-month history of a slowly growing asymptomatic pink lesion on his arm. Read More

    Dermoscopy and reflectance confocal microscopy in pedunculated basal cell carcinoma.
    Dermatol Pract Concept 2017 Apr 30;7(2):51-52. Epub 2017 Apr 30.
    Department of Dermatology, Faculty of Medicine, University of Ege, Izmir, Turkey.
    There have been limited cases of pedunculated basal cell carcinoma (BCC) reported in the literature. The dermoscopic features were described in only one of them. However, not one of them described the confocal microscopy features. Read More

    Triage amalgamated dermoscopic algorithm (TADA) for skin cancer screening.
    Dermatol Pract Concept 2017 Apr 30;7(2):39-46. Epub 2017 Apr 30.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Importance: Dermoscopic triage algorithms have been shown to improve beginners' abilities for identifying pigmented skin lesions requiring biopsy.

    Objective: To estimate the diagnostic accuracy of the Triage Amalgamated Dermoscopic Algorithm (TADA) for pigmented and nonpigmented skin cancers. Secondarily, to compare TADAs performance to those of existing triage algorithms for the identification of pigmented skin cancers. Read More

    Relation of phosphodiesterase type 5 inhibitors and malignant melanoma: a meta-analysis and systematic review.
    Oncotarget 2017 Apr 29. Epub 2017 Apr 29.
    Department of Cardiology, The Second Affiliated and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
    Data on the association between using PDE5 inhibitors and malignant melanoma are conflicting. To estimate the relation of using PDE5 inhibitors with risk of malignant melanoma, Medline (Ovid) and Embase (Ovid) databases were searched up to February 2017, and a random effects model was used to calculate the summary risk estimates. Five observational studies were included. Read More

    Melanoma Is Skin Deep: A 3D Reconstruction Technique for Computerized Dermoscopic Skin Lesion Classification.
    IEEE J Transl Eng Health Med 2017 16;5:4300117. Epub 2017 Jan 16.
    Research and Development TeamPlanet-I Technologies.
    Melanoma mortality rates are the highest amongst skin cancer patients. Melanoma is life threating when it grows beyond the dermis of the skin. Hence, depth is an important factor to diagnose melanoma. Read More

    Tumor-associated myoepithelial cells promote the invasive progression of ductal carcinoma in situ through activation of TGFβ signaling.
    J Biol Chem 2017 May 16. Epub 2017 May 16.
    University of Maryland School of Medicine, United States;
    The normal myoepithelium has a tumor-suppressing nature and inhibits the progression of ductal carcinoma in situ (DCIS) into invasive ductal carcinoma (IDC). Conversely, a growing number of studies have shown that tumor-associated myoepithelial cells have a tumor-promoting effect. Moreover, the exact role of tumor-associated myoepithelial cells in the DCIS-to-IDC development remains undefined. Read More

    Epstein-Barr virus-encoded LMP2A stimulates migration of nasopharyngeal carcinoma cells via EGFR/Ca(2+)/calpain/ITGβ4 axis.
    Biol Open 2017 May 16. Epub 2017 May 16.
    Life Science Institute, Guangxi Medical University, Nanning, China
    Epstein-Barr virus (EBV)-encoded latent membrane protein 2A (LMP2A) promotes the motility of nasopharyngeal carcinoma (NPC) cells. Previously, we have shown that the localization of integrin β4 (ITGβ4) was regulated by LMP2A, with ITGβ4 concentrated at the cellular protrusions in LMP2A expressing NPC cells. In the present study, we aim to further investigate mechanisms involved in this process and its contribution to cell motility. Read More

    Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study.
    BMC Cancer 2017 May 16;17(1):332. Epub 2017 May 16.
    Universitätsklinikum Schleswig-Holstein, Schittenhelmstr, 7, D-24 105, Kiel, Germany.
    Background: In the primary analysis of the ERIVANCE BCC trial, vismodegib, the first US Food and Drug Administration-approved Hedgehog pathway inhibitor, showed objective response rates (ORRs) by independent review facility (IRF) of 30% and 43% in metastatic basal cell carcinoma (mBCC) and locally advanced BCC (laBCC), respectively. ORRs by investigator review were 45% (mBCC) and 60% (laBCC). Herein, we present long-term safety and final investigator-assessed efficacy results in patients with mBCC or laBCC. Read More

    Outer Dense Fiber Proteins: Bridging between Male Infertility and Cancer.
    Arch Iran Med 2017 May;20(5):320-325
    Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: The similarities between gametogenic and carcinogenesis processes have been noted for more than decades. Among prominent similarities between these two processes is expression of a group of antigens, namely cancer-testis antigens in both the testes and various cancer tissues. Outer dense fiber (ODF) proteins are testis-specific proteins localized to sperm tails and involved in sperm motility. Read More

    Association study of genetic variation in DNA repair pathway genes and risk of basal cell carcinoma.
    Int J Cancer 2017 May 16. Epub 2017 May 16.
    Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University, Indianapolis, IN, 46202, USA.
    DNA repair plays a critical role in protecting the genome from ultraviolet radiation and maintaining the genomic integrity of cells. Genetic variants in DNA repair-related genes can influence an individual's DNA repair capacity, which may be related to the risk of developing basal cell carcinoma (BCC). We comprehensively assessed the associations of 2,965 independent single-nucleotide polymorphisms (SNPs) across 165 DNA repair pathway genes with BCC risk in a genome-wide association meta-analysis totaling 17,187 BCC cases and 287,054 controls from two data sets. Read More

    Eradication of basal cell carcinoma of the head and neck using the Surgical Excision with a new Stained Margin Technique: a preliminary study.
    G Ital Dermatol Venereol 2017 May 16. Epub 2017 May 16.
    Dermatology Unit, Maggiore della Carità Hospital, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy.
    Background: Basal Cell Carcinomas (BCCs) are common cutaneous neoplasms that mainly affect fair-skinned subjects, in sun-exposed areas of the body. The treatment of choice of BCCs is represented by surgical excision and different techniques are available, in order to allow the complete eradication of the tumour with the best cosmetic results. In this paper we describe the Surgical Excision with Stained Margin Technique (SMET) and we report its efficacy for the treatment of BCCs of the head and neck region. Read More

    Evaluation of role of alpha-methyl acyl-coenzyme A racemase/P504S and high molecular weight cytokeratin in diagnosing prostatic lesions.
    J Cancer Res Ther 2017 Jan-Mar;13(1):21-25
    Department of Pathology and Anesthesia, Pt. B D Sharma PGIMS, Rohtak, Haryana, India.
    Background: In recent years basal cell markers (high molecular weight cytokeratin [HMWCK]) and prostate biomarker alpha-methyl acyl-coenzyme A racemase (AMACR) have been used as adjuvant to morphology in diagnostically challenging cases with a very high sensitivity and specificity. This has increased the diagnostic accuracy of prostate cancer worldwide.

    Materials And Methods: In this prospective study, total of 50 cases including 37 cases of malignant lesions and 13 cases of benign lesions of the prostate were taken. Read More

    Comparison of the incidence of skin cancers in patients on dialysis and after kidney transplantation.
    Postepy Dermatol Alergol 2017 Apr 13;34(2):138-142. Epub 2017 Apr 13.
    Department of Nephrology, Jagiellonian University Medical College, Krakow, Poland.
    Introduction: Kidney transplant (KTx) patients on immunosuppressive therapy are predisposed to the development of infections and cancers.

    Aim: To compare the incidence and type of malignant skin lesions in kidney transplant patients and the dialyzed population based on the initiated dermatologic screening.

    Material And Methods: The study included 598 patients: 486 kidney transplant recipients and 112 patients on maintenance dialysis. Read More

    Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment.
    Onco Targets Ther 2017 8;10:2483-2489. Epub 2017 May 8.
    Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai, People's Republic of China.
    Basal cell carcinoma (BCC) is a common malignant tumor throughout the world. One of the known risk factors of BCC is intense exposure to ultraviolet radiation. More than 50% of BCCs of the eyelid initially occur on the lower lid. Read More

    Methyl-aminolevulinate Photodynamic Therapy combined with curettage debulking for pigmented Basal Cell Carcinoma.
    Photodermatol Photoimmunol Photomed 2017 May 13. Epub 2017 May 13.
    Dermatology Service, Hospital San Jorge, Huesca, Spain.
    Basal cell carcinoma (BCC) is the most common skin cancer, with an incidence rate in Spain of 113.05 cases per 100 000 person-years (CI95%, 89.03-137. Read More

    FOXM1 predicts overall and disease specific survival in muscle-invasive urothelial carcinoma and presents a differential expression between bladder cancer subtypes.
    Oncotarget 2017 Apr 24. Epub 2017 Apr 24.
    Department of Urology, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
    Forkhead box M1 (FOXM1) is a late cell cycle gene that plays a crucial role in carcinogenesis and chemotherapeutic drug resistance. In this study, the impact of FOXM1 expression on patient outcome was investigated for the first time in formalin fixed and paraffin embedded (FFPE) samples of chemotherapy naïve muscle-invasive bladder cancer (MIBC) patients. Expression analyses were performed on the Mannheim cohort (n=84) and validated on the independent Chungbuk cohort (n=61). Read More

    UVA-induced upregulation of progerin suppresses 53BP1‑mediated NHEJ DSB repair in human keratinocytes via progerin-lamin A complex formation.
    Oncol Rep 2017 Jun 26;37(6):3617-3624. Epub 2017 Apr 26.
    Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, P.R. China.
    Ultraviolet (UV) radiation is the primary risk factor underlying photoaging and photocarcinogenesis. Mounting research has focused on the role of DNA damage response pathways in UV-induced double-strand break (DSB) repair. In the present study, we hypothesized that UVA-induced aberrant progerin upregulation may adversely affect p53-binding protein 1 (53BP1)-mediated non-homologous end joining (NHE) DSB repair in human keratinocytes. Read More

    Sarcoidosis Discovered During Mohs Surgery for Basal Cell Carcinoma.
    Dermatol Surg 2017 May 10. Epub 2017 May 10.
    Division of Dermatology, Department of Medicine, University of Louisville, Louisville, Kentucky School of Medicine, University of Mississippi, Oxford, Mississippi Division of Dermatology, Department of Medicine, University of Louisville, Louisville, Kentucky Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, Kentucky Micrographic Surgery and Dermatologic Oncology Fellowship, Division of Dermatology, Department of Medicine, University of Louisville, Louisville, Kentucky.

    Multisystem Involvement in a Patient with a PTCH1 Mutation: Clinical and Imaging Findings.
    J Pediatr Genet 2017 Jun 14;6(2):103-106. Epub 2016 Sep 14.
    Departamento de Genética, Instituto de Ciências Biológicas, Universidade Federal de Goias, Goiania, Goiás, Brazil.
    In this article, we report on a Brazilian female patient born to consanguineous parents and presenting with alobar holoprosencephaly, severe eye involvement, and unusual skin hyperpigmented lesions. She was found to have a mutation (c.2240T > C; p. Read More

    Clinical applications of 3-dimensional printing in radiation therapy.
    Med Dosim 2017 Summer;42(2):150-155. Epub 2017 May 8.
    Department of Medical Physics, Dalhousie University, Queen Elizabeth II Health Sciences Centre, 5820 University Avenue, Halifax, Nova Scotia B3H 2Y9, Canada.
    Three-dimensional (3D) printing is suitable for the fabrication of complex radiotherapy bolus. Although investigated from dosimetric and feasibility standpoints, there are few reports to date of its use for actual patient treatment. This study illustrates the versatile applications of 3D printing in clinical radiation oncology through a selection of patient cases, namely, to create bolus for photon and modulated electron radiotherapy (MERT), as well as applicators for surface high-dose rate (HDR) brachytherapy. Read More

    Superficial Basal Cell Carcinoma: a comparison of Superficial only Subtype with Superficial combined with other Subtypes by Age, Sex and Anatomic Site in 3,150 cases.
    J Cutan Pathol 2017 May 11. Epub 2017 May 11.
    The University of New South Wales, Sydney, Australia.
    Background: Basal Cell Carcinoma (BCC) may present as superficial subtype alone (sBCC) or superficial combined with other subtypes.

    Objective: To compare sBCC without or with other BCC subtypes by age, sex and anatomic site.

    Methods: We retrospectively collected superficial BCC with the above characteristics from an Australian centre during 2009-14. Read More

    GLI3 Repressor Determines Hedgehog Pathway Activation and is Required for Response to SMO Antagonist Glasdegib in AML.
    Blood 2017 May 9. Epub 2017 May 9.
    Division of Hematology, Department of Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States;
    The Hedgehog (Hh) signaling pathway is activated in many cancers and is a promising target for therapeutic development. Deletions in the receptor Patched (PTCH) or activating mutations in Smoothened (SMO) have been reported in basal cell carcinoma (BCC) and medulloblastoma, but are largely absent in most tumor types; therefore, the mechanism of pathway activation in most cancers, including hematological malignancies, remains unknown. In normal tissues, Hh pathway activation via PTCH/SMO causes an increase in the downstream transcriptional activator GLI1 and a decrease in the transcriptional repressor GLI3R. Read More

    FBP1 modulates cell metabolism of breast cancer cells by inhibiting the expression of HIF-1α.
    Neoplasma 2017 May 9;64. Epub 2017 May 9.
    This study aimed to investigate the function of fructose-1, 6-bisphosphatase 1 (FBP1) in regulating cell growth and metabolism through hypoxia-inducible factor 1α (HIF-1α)-dependent hypoxic response in breast cancer cells. Two human breast carcinoma cell lines, including luminal-like cell line MCF-7 and basal-like cell line MDA-MB-468, were cultured under hypoxia condition, then the expressions of FBP1 and HIF-1α were detected by western blotting. In addition, up-regulated FPB1 in MDA-MB-468 cells were induced by lentivirus. Read More

    Non-Melanoma Skin Cancers of the Fronto-Temporal Area Preferentially Localize in the Proximity of Arterial Blood Vessels.
    Dermatology 2017 May 9. Epub 2017 May 9.
    Department of Dermatology and Venereology, Hôpital de Beaumont, Lausanne University Hospital Center, Lausanne, Switzerland.
    Background: Squamous cell carcinomas and basal cell carcinomas are both induced by chronic UV exposure. However, their predilection for specific areas of the face remains unexplained. Regional factors such as arterial blood flow may explain specific tumor localization. Read More

    Sun exposure and skin cancer, and the puzzle of cutaneous melanoma: A perspective on Fears et al. Mathematical models of age and ultraviolet effects on the incidence of skin cancer among whites in the United States. American Journal of Epidemiology 1977; 105: 420-427.
    Cancer Epidemiol 2017 May 3. Epub 2017 May 3.
    Cancer Epidemiology and Prevention Research Group, School of Public Health, The University of Sydney, NSW, Australia; The Melanoma Institute Australia, North Sydney, NSW, Australia.
    Sunlight has been known as an important cause of skin cancer since around the turn of the 20th Century. A 1977 landmark paper of US scientists Fears, Scotto, and Schneiderman advanced a novel hypothesis whereby cutaneous melanoma was primarily caused by intermittent sun exposure (i.e. Read More

    Ocular myiasis in a glioma: a case report.
    Nepal J Ophthalmol 2016 Jul;8(16):167-170
    Background: Ocular myiasis though rare, is usually found in association with basal cell carcinoma. It is rarer still in tumors other than basal cell carcinoma. We report a case of ocular myiasis in a glioma which is hitherto unreported to the best of our knowledge. Read More

    Activated thyroid hormone receptor modulates dioxin-inducible aryl hydrocarbon receptor-mediated CYP1A1 induction in human hepatocytes but not in human hepatocarcinoma HepG2 cells.
    Toxicol Lett 2017 Jun 3;275:77-82. Epub 2017 May 3.
    Department of Cell Biology and Genetics, Faculty of Science, Palacky University in Olomouc, Slechtitelu 27, Olomouc, CZ-783 71, Czech Republic.
    Aryl hydrocarbon receptor (AhR) is a transcription factor, the activity of which is modulated by hormones including glucocorticoids and estrogens. In this study, we examined the effects of triiodothyronine (T3), a ligand and activator of thyroid hormone receptor (TR), on transcriptional activity of AhR and the expression of its target gene CYP1A1. Study was carried out in human hepatocellular carcinoma cells HepG2 and primary cultures of human hepatocytes (HH). Read More

    [Role of Köllner-Hughes tarsoconjunctival flap in the reconstruction of large eyelid defects].
    J Fr Ophtalmol 2017 May 3;40(5):363-370. Epub 2017 May 3.
    Service d'ophtalmologie adulte, hôpital 20-Août-1953, CHU Ibn-Rochd, quartier des Hôpitaux, Casablanca, Maroc.
    Purpose: To evaluate the aesthetic and functional results of the Köllner-Hughes tarsoconjonctival flap technique for large defects of over three-quarter of the lower eyelid.

    Patients And Methods: A retrospective descriptive study of a series of 15 patients treated between January 2013 and December 2015. We included all patients who underwent reconstructive surgery for a tumor involving more than three-quarter of the lower eyelid and sparing the canthi. Read More

    Genetic association between TNF-α promoter polymorphism and susceptibility to squamous cell carcinoma, basal cell carcinoma, and melanoma: A meta-analysis.
    Oncotarget 2017 Apr 18. Epub 2017 Apr 18.
    Department of General Surgery, Bailou Hospital, Tianjin 300040, PR China.
    Tumor necrosis factor-alpha (TNF-α) is a multifunctional pro-inflammatory cytokine that plays an important role in cancer development. We performed a meta-analysis to assess the relationship between single nucleotide polymorphisms in the TNF-α promoter region (rs1800629 and rs361525) and susceptibility to squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and melanoma. After database retrieval, article selection, data extraction, and quality assessment, 20 articles comprising 4865 cases and 6329 controls were included in this study. Read More

    The role of autophagy in hepatocellular carcinoma: friend or foe.
    Oncotarget 2017 Apr 18. Epub 2017 Apr 18.
    Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Autophagy is an evolutionarily conserved lysosome-dependent catabolic process which degrades cell's components in order to recycle substrates to exert optimally and adapt to tough circumstances. It is a critical cellular homeostatic mechanism with stress resistance, immunity, antiaging, and pro-tumor or anti-tumor effects. Among these, the role of autophagy in cancer is the most eye-catching that is not immutable but dynamic and highly complex. Read More

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