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    1 OF 506

    Unusual triple combination of prostate, lung and skin cancer.
    Rom J Morphol Embryol 2017 ;58(2):567-574
    Department of Pathology, "Colentina" Clinical Hospital, Bucharest, Romania;
    Multiple malignancies are an increasing combination in the recent years in cancer patients, due to prolonged survival rate and to the advances in diagnostic techniques and therapeutic management. We present the case of a patient diagnosed with prostate cancer and metachronous in one year with basal cell carcinoma of the skin and small lung cell carcinoma with lymph nodes and pararectal metastasis. To our best knowledge, this is the only case presented in the medical literature with these three different types of primary malignancy. Read More

    Histopathological aspects of some rare forms of facial basal cell carcinoma.
    Rom J Morphol Embryol 2017 ;58(2):425-432
    Department of Prosthetics, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, Romania;
    Aim: The main objective of the study was to highlight the histopathological aspects of some rare forms of facial basal cell carcinomas.

    Patients, Materials And Methods: The 65 selected patients were diagnosed with head basal cell carcinoma (BCC), during 2011-2013, and they underwent surgery. The excised tumor tissue fragments were processed for paraffin embedding and stained with Hematoxylin-Eosin (HE), Masson's trichrome with Aniline Blue, and Alcian Blue-Periodic Acid Schiff (AB-PAS). Read More

    Is new American Thyroid Association risk classification for hereditary medullary thyroid carcinoma applicable to Chinese patients? A single-center study.
    Chin J Cancer Res 2017 Jun;29(3):223-230
    Department of Head and Neck Surgical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China.
    Objective: The American Thyroid Association (ATA) proposed a new risk classification for hereditary medullary thyroid carcinoma (MTC) in 2015. This study aimed to assess whether the new guidelines are suitable for the Chinese population, and reported our experience on prophylactic thyroidectomy.

    Methods: A total of 73 patients from 22 families were screened as rearranged during transfection (RET) mutation carriers from 2010 to 2016 in Cancer Hospital, Chinese Academy of Medical Science; the medical history for each patient was collected. Read More

    Phosphodiesterase type 5 inhibitors and risk of melanoma: A meta-analysis.
    J Am Acad Dermatol 2017 Jul 17. Epub 2017 Jul 17.
    Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana; Center for Pharmacoepidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana. Electronic address:
    Background: The association between phosphodiesterase type 5 (PDE5) inhibitors and melanoma risk is controversial.

    Objective: We quantify the association between use of PDE5 inhibitors and melanoma.

    Methods: We systematically searched PubMed, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, and ClinicalTrials. Read More

    Reconstruction of Large Facial Defects via Excision of Skin Cancer Using Two or More Regional Flaps.
    Arch Plast Surg 2017 Jul 15;44(4):319-323. Epub 2017 Jul 15.
    Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Busan, Korea.
    Background: Free-flap surgery and skin grafting can be used to reconstruct large facial defects that may result after skin cancer removal by Mohs micrographic surgery (MMS). However, these two methods may produce low postsurgical patient satisfaction with aesthetics, and free-flap surgery may produce an undue burden for the majority of skin cancer patients, who are of advanced age. Hence, the authors examined outcomes of large facial defect reconstruction using multiple flaps. Read More

    Non-Melanocytic Skin Cancers of the Head and Neck: A Clinical Study in Jeju Province.
    Arch Plast Surg 2017 Jul 15;44(4):313-318. Epub 2017 Jul 15.
    Department of Plastic and Reconstructive Surgery, Jeju National University School of Medicine, Jeju, Korea.
    Background: Jeju Island is geographically and socioeconomically distinct from the mainland of South Korea. Thus, the presentation and management of non-melanocytic skin cancers (NMSC) of the head and neck may differ from those in other regions of the country. We compared the clinical characteristics and treatment modalities of NMSC on Jeju Island with the findings of similar regional studies. Read More

    Immunohistochemical Expression of MYB in Salivary Gland Basal Cell Adenocarcinoma and Basal Cell Adenoma.
    J Oral Pathol Med 2017 Jul 20. Epub 2017 Jul 20.
    Department of Pathology, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242.
    Background: Basal cell predominant salivary gland neoplasms can be difficult to separate histologically. One of the most aggressive of basaloid salivary gland neoplasms is adenoid cystic carcinoma. MYB expression by immunohistochemistry has been documented in adenoid cystic carcinoma. Read More

    Two years results of electronic brachytherapy for basal cell carcinoma.
    J Contemp Brachytherapy 2017 Jun 5;9(3):251-255. Epub 2017 Jun 5.
    Dermatology Department.
    Purpose: The use of radiation therapy (RT) for non-melanoma skin cancer (NMSC) has been changing throughout the last century. Over the last decades, the use of radiotherapy has surged with the development of new techniques, applicators, and devices. In recent years, electronic brachytherapy (eBT) devices that use small x-ray sources have been introduced as alternative to radionuclide dependence. Read More

    TNF is a key cytokine mediating neutrophil cytotoxic activity in breast cancer patients.
    NPJ Breast Cancer 2016 20;2:16009. Epub 2016 Apr 20.
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    We have previously shown a novel antimetastatic role for neutrophils in the premetastatic lung of mice in models of breast cancer. Here we expand on those findings in the context of human breast cancer. We assessed the cytotoxicity of neutrophils from 90 newly diagnosed breast cancer patients, 24 ductal carcinoma in situ patients, 56 metastatic breast cancer patients, and 64 women with no history of cancer. Read More

    Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma.
    Oncogene 2017 Jul 17. Epub 2017 Jul 17.
    Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, University of Miami, Miller School of Medicine, Miami, FL, USA.
    The SMOOTHENED inhibitor vismodegib is FDA approved for advanced basal cell carcinoma (BCC), and shows promise in clinical trials for SONIC HEDGEHOG (SHH)-subgroup medulloblastoma (MB) patients. Clinical experience with BCC patients shows that continuous exposure to vismodegib is necessary to prevent tumor recurrence, suggesting the existence of a vismodegib-resistant reservoir of tumor-propagating cells. We isolated such tumor-propagating cells from a mouse model of SHH-subgroup MB and grew them as sphere cultures. Read More

    Inhibition of STAT3 signaling pathway by ursolic acid suppresses growth of hepatocellular carcinoma.
    Int J Oncol 2017 Aug 8;51(2):555-562. Epub 2017 Jun 8.
    Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.
    The signal transducer and activator of transcription 3 (STAT3) has been found to be constitutively active in liver cancer. There is no STAT3 inhibitors approved to be used clinically for the treatment or prevention of liver cancer. Some dietary compounds including ursolic acid (UA) have been reported to inhibit the growth of cancer cells. Read More

    Neuroendocrine factors: The missing link in non‑melanoma skin cancer (Review).
    Oncol Rep 2017 Jul 13. Epub 2017 Jul 13.
    Laboratory of Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece.
    Non‑melanoma skin cancer (NMSC) is the most common form of cancer worldwide, comprising 95% of all cutaneous malignancies and approximately 40% of all cancers. In spite of intensive efforts aimed towards awareness campaigns and sun‑protective measures, epidemiological data indicate an increase in the incidence of NMSC. This category of skin cancers has many common environmental triggers. Read More

    Removal of Multiple Keratocystic Odontogenic Tumors in a Nonsyndromic Patient.
    Ann Maxillofac Surg 2017 Jan-Jun;7(1):136-139
    Department of Dental Research, Cuiabá Dental School, University of Cuiabá, Cuiabá, MT, Brazil.
    Multiple keratocystic odontogenic tumors are one of the key features of Gorlin-Goltz syndrome. A 15-year-old nonsyndromic female child presented with multiple keratocystic odontogenic tumors. The presence of the tumors was observed in immunological examinations. Read More

    Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells.
    Acta Pharmacol Sin 2017 Jul 17. Epub 2017 Jul 17.
    Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
    Hepatocellular carcinoma (HCC) is one of the most refractory cancers. The mechanisms by which hypoxia further aggravates therapeutic responses of advanced HCC to anticancer drugs remain to be clarified. Here, we report that hypoxia (1% O2) caused 2. Read More

    Early Life UV and Risk of Basal and Squamous Cell Carcinoma in New South Wales, Australia.
    Photochem Photobiol 2017 Jul 15. Epub 2017 Jul 15.
    Sydney School of Public Health, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.
    Sun exposure is the main cause of squamous (SCC) and basal cell carcinoma (BCC) although pattern and amount differ by cancer type, and sun sensitivity is the major host risk factor. Our study investigated risk factors and residential ambient UV in a population-based sample of Australian 45 and Up Study participants: 916 BCC cases, 433 SCC cases, 1224 controls. Unconditional logistic regression models adjusting for key covariates demonstrated 60% increased BCC risk and 2-fold increased SCC risk with sun sensitivity, and 3- and 4-fold increased risk respectively with solar keratoses. Read More

    Margin Analysis: Cutaneous Malignancy of the Head and Neck.
    Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):341-353
    Department of Pathology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA.
    This article focuses only on margin analysis of the cutaneous malignancy of the skin. It discusses basal cell carcinoma, squamous cell carcinoma, and cutaneous melanoma. The management of the neck and distant disease are beyond the scope of this article, but it answers what is the appropriate surgical margin when excising these skin tumors, whether frozen sections are accurate for the analysis of these tumors, and treatment algorithm and rationale for a positive resection margin. Read More

    Nationwide Trends in the Incidence of Melanoma and Non-melanoma Skin Cancers from 1999 to 2014 in South Korea.
    Cancer Res Treat 2017 Jul 14. Epub 2017 Jul 14.
    Cancer registration and statistic branch, National Cancer Control Institute, National Cancer Center, Goyang, Korea.
    Purpose: This descriptive study was aimed to examine trends in the incidence of melanoma and non-melanoma in South Korea.

    Materials And Methods: The nationwide incidence data for melanoma and non-melanoma skin cancer was obtained from the Korea Central Cancer Registry. Age-standardized rates were calculated and analyzed, using a joinpoint regression model. Read More

    Perineural invasion present exclusively in central tissue blocks of Mohs surgical excisions of basal cell carcinoma.
    Australas J Dermatol 2017 Jul 14. Epub 2017 Jul 14.
    Dermatology Specialist Centre, Brisbane, Queensland, Australia.
    Perineural invasion (PNI) may be present in basal cell carcinomas (BCC) treated with Mohs micrographic surgery. This single-centre, non-randomised, prospective study demonstrates the potential for PNI to exist exclusively within the central tissue blocks of Mohs specimens. Read More

    Hard to face: cutaneous malignant melanoma.
    J Biol Regul Homeost Agents 2017 07 13;31(2 Suppl. 2). Epub 2017 Jul 13.
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    An 88-year-old Caucasian man recently sought medical attention due to recrudescence of skin disease in the area of previously excised nodule (in 2002) on the nose dorsum. The original lesion was clinically considered as a pigmented basal cell carcinoma, after which histological examination revealed a superficial spreading melanoma in vertical growth face (Clark level IV; Breslow thickness 2.1 mm) arising from a pre-existing nevus. Read More

    Association of Multiple Primary Skin Cancers With Human Immunodeficiency Virus Infection, CD4 Count, and Viral Load.
    JAMA Dermatol 2017 Jul 12. Epub 2017 Jul 12.
    Division of Research, Kaiser Permanente Northern California, Oakland.
    Importance: Persons with human immunodeficiency virus (HIV) have a 2.8-fold higher risk than HIV-uninfected persons of nonmelanoma skin cancer (NMSC), defined as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Individuals with a prior NMSC history are at increased risk for subsequent NMSC, but the magnitude of risk and its relation to HIV disease-related factors, including CD4 count and viral load (VL), are unknown. Read More

    Adenosquamous gallbladder carcinoma: Multigene hotspot mutational profiling reveals a monoclonal origin of the two components.
    Pathol Res Pract 2017 May 23. Epub 2017 May 23.
    Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy. Electronic address:
    Adenosquamous carcinoma (ASC) of the gallbladder is a rare malignant tumor that is characterized by a coexisting of glandular and squamous components. In a case of ASC, we performed hotspot multigene mutational profiling of 164 hotspot regions of eleven cancer-associated genes (AKT1, APC, BRAF, CTNNB1, KIT, KRAS, NRAS, PDGFRA, PIK3CA, PTEN and TP53) in the two microdissected components. Both tumor phenotypes resulted characterized by a p. Read More

    Expression of FOXC2, PinX1, Ki-67 and Cyclin D1 in cutaneous cell carcinoma.
    Oncol Lett 2017 Jul 24;14(1):635-638. Epub 2017 May 24.
    Department of Dermatology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China.
    We investigated the expression of FOXC2, PinX1, Ki-67 and Cyclin D1 in cutaneous cell carcinoma. We collected 30 cutaneous squamous cell carcinoma (SCC), 30 cutaneous basal cell carcinoma (BCC) and 30 normal skin tissues. The protein expression and gene expression of FOXC2, endogenous telomerase-inhibiting gene PinX1, Ki-67 and Cyclin D1 was measured by immunohistochemistry (IHC) and semi-quantitative reverse transcription polymerase chain reaction (RT-PCR), respectively. Read More

    Reappraisal of the Confusing Concept "Trichogerminoma" and the Ill-Defined Finding "Cell Balls": Clinicopathologic Analysis of 6 Cases of Trichogerminoma and Comparison With 2 Cases of Basal Cell Carcinoma With Cell Ball-Like Features.
    Am J Dermatopathol 2017 May 18. Epub 2017 May 18.
    *Department of Pathology and Cytology, Karolinska University Hospital, Huddinge, Sweden †Department of Diagnostic Pathology, Kainan Hospital, Aichi, Japan ‡Department of Dermatology, Hyogo Cancer Center, Akashi, Japan §Sapporo Dermatopathology Institute, Sapporo, Japan ¶Fukumoto Dermatopathology Clinic, Nara, Japan ‖Izumi Dermatology Clinic, Akita, Japan **Department of Dermatology, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan ††Department of Plastic Surgery, Kainan Hospital, Aichi, Japan.

    The use of lasers in the treatment of skin cancer: A review.
    J Cosmet Laser Ther 2017 Jul 10. Epub 2017 Jul 10.
    a Yale School of Medicine , Yale University , New Haven , CT , USA.
    Background: In considering skin cancer, a number of factors - including effectiveness, simplicity of treatment, cost, and aesthetic outcomes - are important to ensure patient satisfaction. There are several existing interventions, such as electrodessication and curettage, excision, Mohs surgery, radiation therapy, cryotherapy, and topical/oral treatments. Laser therapy has emerged as a new promising alternative that should be explored. Read More

    Nasal reconstruction: our experience.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2 Suppl 1):169-174
    Maxillofacial and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.
    The nose is a critically important aesthetic and functional portion of the face. We can explore nasal defects following trauma or tumor resections. Reconstructive techniques based on primary closure, skin graft, local flap, regional flap and microvascular free tissue transfer provides an algorithmic framework applicable to any reconstructive problem. Read More

    Vacuum-assisted closure therapy after resection of giant basal cell carcinoma of the scalp.
    J Surg Case Rep 2017 Jul 4;2017(7):rjx122. Epub 2017 Jul 4.
    General Surgery Service (Extradigestive Unit), Department of Surgery, Santo António Hospital-Oporto Hospital Centre, Oporto, Portugal.
    Management of complicated wounds is a challenge in head and neck reconstruction. Although the negative pressure wound therapy or wound vacuum-assisted closure has been widely used in complicated wounds and shows promising results, its application in the head and neck region after reconstruction for the head and neck cancer is rarely presented. A 77-year-old woman underwent a radical resection of an extensive basal cell carcinoma of the scalp and forehead involving the periosteum, where classic reconstruction was difficult, but successfully treated with negative pressure wound therapy. Read More

    Delayed Diagnosis of Basal Cell Carcinoma of the Upper Lip: The Possible Role of Incidental Multinucleated Foreign Body Giant Cells.
    Case Rep Dermatol 2017 May-Aug;9(2):50-54. Epub 2017 Jun 16.
    Department of Dermatology, University of Texas Medical Branch, Galveston, Texas, USA.
    Herpes simplex and basal cell carcinoma (BCC) can have similar clinical presentations due to overlapping lesional morphology. We describe the unusual case of a BCC masquerading as herpes labialis due to a possible false-positive Tzanck smear. The confounding diagnosis led to a failed trial of valacyclovir and subsequent loss of the patient for 1 year before the lesion was biopsied and diagnosed as a BCC. Read More

    Deregulation of miR-126-3p in basal-like breast cancers stroma and its clinical significance.
    Pathol Res Pract 2017 May 31. Epub 2017 May 31.
    Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital Affiliated with Zhejiang University, Huzhou, 313000, China. Electronic address:
    Introduction: The aim of this study was to investigate miR-126-3p expression in stroma and tumor cells of basal-like breast cancer tissues, in an effort to elucidate the potential effect of miR-126-3p on tumor microenvironment and progress of basal-like breast cancer.

    Methods: Expression levels of miR-126-3p in 33 paired basal-like breast cancer tissues were assayed by real-time quantitative PCR. Tumor cells and normal epithelial cell were isolated from ten paired basal-like breast cancer tissues and matched adjacent tissues, separately, using laser capture microdissect(LCM)-based PCR method. Read More

    Muckle-Wells syndrome in the setting of basal cell nevus syndrome.
    Cutis 2017 Jun;99(6):421-424
    Advanced Dermatology Associates, Allentown, USA.
    Muckle-Wells syndrome (MWS) is a rare disorder inherited in an autosomal-dominant fashion that belongs to a group of hereditary periodic fever syndromes. It specifically belongs to the cryopyrin-associated periodic syndromes (CAPSs) in which there is a mutation in the NLRP3 (NLR family pyrin domain containing 3) gene that leads to overproduction of IL-1β, the source of the multisystem inflammatory symptoms. Muckle-Wells syndrome is characterized by a recurrent urticarial eruption that is associated with episodic fever, myalgia, arthralgia, malaise, progressive sensorineural hearing loss, and amyloid nephropathy (the most severe complication). Read More

    BRD4 promotes gastric cancer progression through the transcriptional and epigenetic regulation of c-MYC.
    J Cell Biochem 2017 Jul 6. Epub 2017 Jul 6.
    Intracelom Hyperthermic Perfusion Therapy Center, Cancer Hospital of Guangzhou Medical University, Guangzhou 510095, P.R. China.
    Although the significance of BRD4 in the epigenetic memory and cancer genesis has been intensively investigated, little is known about its function and potential roles during the generation and progression of gastric cancer. We report here that BRD4 increases the proliferation and represses the apoptosis of gastric cancer cells through activating c-MYC via transcriptional and epigenetic regulation mechanisms. Expression analyses in both small and large cohort of sample show that BRD4 is highly expressed in gastric cancer tissues/cells when compared with the adjacent non-tumor tissues/normal cells. Read More

    Association of atopy and tentative diagnosis of skin cancer - results from occupational skin cancer screenings.
    J Eur Acad Dermatol Venereol 2017 Jul 6. Epub 2017 Jul 6.
    CVderm - German Center for Health Services Research in Dermatology, German Center for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
    Background: The relationship between atopic conditions and carcinoma of the skin has been described inconsistently. Population-based data providing information on atopic diseases as well as on skin-cancer are sparse.

    Objective: To determine the correlation between atopy and prevalence of precanceroses, nonmelanoma skin-cancer and malignant melanoma (MM), while taking into account known risk factors for skin cancer. Read More

    Sebaceous Carcinoma: A Review of the Scientific Literature.
    Curr Treat Options Oncol 2017 Aug;18(8):47
    Department of Dermatology, Columbia University Medical Center, New York, NY, 10032, USA.
    Opinion Statement: Sebaceous carcinoma is a rare and potentially aggressive cutaneous malignancy. Commonly reported in the periocular area and the head and neck region, sebaceous carcinoma can arise from any sebaceous gland in the skin. The clinical presentation may be nonspecific, and a biopsy is important to establish a diagnosis and to differentiate from mimickers including benign sebaceous neoplasms, other adnexal tumors, and basal cell carcinoma. Read More

    Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours.
    Curr Treat Options Oncol 2017 Aug;18(8):49
    St Helens and Knowsley Teaching Hospitals NHS Trust, Marshalls Cross Road, St Helens, WA9 3DA, UK.
    Opinion Statement: Microcystic adnexal carcinoma (MAC) is a rare, slow-growing, infiltrative malignant tumour most commonly found on the head and neck. It often presents as a solitary skin-coloured or yellow papule, plaque or nodule. Ultraviolet radiation, immunosuppression and ionising radiation are possible risk factors. Read More

    TdT expression in normal and neoplastic sebaceous cells.
    Histopathology 2017 Jul 5. Epub 2017 Jul 5.
    Pathology Department, Faculty of Medicine, Aristotle University of Thessaloniki, Greece.
    Aims: Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase expressed in immature, normal and neoplastic, lymphoid or hematopoietic cells and in neuroendocrine carcinomas, like Merkel cell carcinoma and small cell carcinoma. It has not yet been described in cells of epithelial origin. After observing TdT immunoreactivity in normal sebaceous glands we analyzed its spectrum of expression in cases of sebaceous cell hyperplasia and sebaceous cell neoplasms. Read More

    Reconstruction of Cheek Defects Secondary to Mohs Microsurgery or Wide Local Excision.
    Facial Plast Surg Clin North Am 2017 Aug;25(3):443-461
    Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical Center, 1500 East Medical Center Drive SPC 5312, 1904 Taubman Center, Ann Arbor, MI 48109-5312, USA. Electronic address:
    Successful reconstruction of the cheek following excision for cutaneous malignancy requires careful consideration of defect location, size, and depth in relation to the anatomic properties of the affected cheek unit. Various reconstructive options are available to the surgeon, ranging from simple excisions to complex cervicofacial advancements to meet the needs for functional and aesthetically pleasing reconstructive outcomes. The surgeon must prevent distortion of mobile structures, such as the eyelid, nose, and lips; respect aesthetic subunits; and avoid blunting natural creases. Read More

    Anatomy of the Skin and the Pathogenesis of Nonmelanoma Skin Cancer.
    Facial Plast Surg Clin North Am 2017 Aug 30;25(3):283-289. Epub 2017 May 30.
    The Mount Sinai Health System at CareMount Medical, 111 Bedford Road, Katonah, NY 12533, USA. Electronic address:
    Skin is composed of the epidermis, dermis, and adnexal structures. The epidermis is composed of 4 layers-the stratums basale, spinosum, granulosum, and corneum. The dermis is divided into a superficial papillary dermis and deeper reticular dermis. Read More

    Red Dot Basal Cell Carcinoma.
    J Clin Aesthet Dermatol 2017 May 1;10(5):56-58. Epub 2017 May 1.
    Department of Dermatology, University of California San Diego, La Jolla, California.
    Red dot basal cell carcinoma, a distinctive morphologic variant of basal cell carcinoma that presents as a small red macule (dot) or papule, is described on a woman's thigh. A high index of suspicion is necessary to consider the diagnosis since the tumor mimics a telangiectasia or an angioma. Read More

    Patient preferences for the attributes of a non-invasive treatment for superficial Basal cell carcinoma: a discrete choice experiment.
    Br J Dermatol 2017 Jul 1. Epub 2017 Jul 1.
    Department of Dermatology, Maastricht University Medical Centre, Maastricht, the Netherlands.
    To examine which attributes of a non-invasive treatment for superficial BCC (sBCC) are valued by patients, a discrete choice experiment (DCE) was performed alongside a clinical trial in which methylaminolevulinate photodynamic therapy (MAL-PDT), 5-fluorouracil and imiquimod were compared.(1) Treatment options were described by the following attributes: effectiveness, cosmetic result, treatment process and side-effects. Effectiveness was defined as the probability that complete tumour clearance is achieved 12 months after treatment with levels of 75%,80%,85% and 90%. Read More

    Single-Nucleotide Polymorphisms of the MSH2 and MLH1 Genes, Potential Molecular Markers for Susceptibility to the Development of Basal Cell Carcinoma in the Brazilian Population.
    Pathol Oncol Res 2017 Jun 30. Epub 2017 Jun 30.
    Laboratório de Biologia Molecular Estrutural e Oncogenética - LBMEO, Universidade Federal da Paraíba, João Pessoa, PB, Brazil.
    Basal cell carcinoma - BCC is considered a multifactorial neoplasm involving genetic, epigenetic and environmental factors. Where UVB radiation is considered the main physical agent involved in BCC carcinogenesis. The Brazil and state of Paraíba are exposed to high levels of UVB rays. Read More

    High-grade squamous intraepithelial lesion (HSIL) of the cervix with bizarre cytological appearances ('pleomorphic HSIL'): a review of 19 cases.
    Pathology 2017 Aug 27;49(5):465-470. Epub 2017 Jun 27.
    Department of Pathology King Edward Memorial Hospital, Perth, WA, Australia; School of Women's and Infants' Health, University of Western Australia, Perth, WA, Australia. Electronic address:
    Cervical high-grade squamous intraepithelial lesions (HSILs) are typically characterised by a proliferation of immature basaloid cells with relatively uniform hyperchromatic nuclei. In this report we describe 19 cases of HSIL exhibiting focal but very marked nuclear atypia often associated with multinucleation ('pleomorphic HSIL'). The bizarre cytological changes mainly involved the basal epithelium particularly in endocervical crypts where the neoplastic cells undermined the native glandular epithelial cells. Read More

    Lower Eyelid Reconstruction After Ablation of Skin Malignancies: How Far Can We Get in a Single-Stage Procedure?
    J Craniofac Surg 2017 Jul;28(5):e477-e479
    *Department of Plastic Reconstructive and Aesthetic Surgery, Uni Hospital, Panagyurishte †Department of Dermatovenereology and Allergology, Military Medical Academy, Sofia, Bulgaria.
    : Reconstruction of full-thickness lower eyelid defects tends to be a devastating procedure, especially when big amount of tissue has to be removed because of oncological reasons. The applied techniques are mostly difficult to execute and multistaged, often require extensive dissection, and result in scarring and facial disfigurement.The aim of the present study is to demonstrate the authors' experience in single-staged reconstructions of full-thickness defects of the lower eyelid with local tissue only. Read More

    Occurrence of metachronous basal cell carcinomas: a prognostic model.
    Br J Dermatol 2017 Jun 30. Epub 2017 Jun 30.
    Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
    Background: A third of patients with a first basal cell carcinoma (BCC) will develop subsequent (metachronous) BCCs.

    Objectives: We studied the prognostic effect of the number of previous BCC diagnosis dates a patient has experienced and derived a prediction model to assess the risk of metachronous BCCs that may inform individualized decision making on surveillance.

    Methods: We considered participants of north-western European ancestry from a prospective population-based cohort study (Rotterdam Study). Read More

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