Search Our Scientific Publications & Authors

Eur J Pharm Biopharm 2019 Feb 13. Epub 2019 Feb 13.

Division of Advanced Materials and Healthcare Technologies, School of Pharmacy, The University of Nottingham, NG7 2RD, UK. Electronic address:

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only licensed by the FDA for superficial BCC. Read More

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address:

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Laser & Skin Surgery Center of New York, New York, NY; The Ronald O. Perelman Department of Dermatology, New York University, New York, NY.

BMC Genomics 2019 Feb 15;20(1):140. Epub 2019 Feb 15.

Anhui Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei, 230031, Anhui, People's Republic of China.

Background: Hair fibre length is an important economic trait of rabbits in fur production. However, molecular mechanisms regulating rabbit hair growth have remained elusive.

Results: Here we aimed to characterise the skin traits and gene expression profiles of short-hair and long-hair rabbits by histological and transcriptome analyses. Read More

Clin Exp Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Medway NHS Foundation Trust, Gillingham, Kent, UK.

Background: There is a paucity of published evidence of established teledermatology (TD) services in the UK. An in-house TD service using store-and-forward technology was set up at a large regional dermatology department in 2004.

Aim: To review the TD service at our centre, including teleconsultation numbers, coding of diagnoses and patient outcomes. Read More

J Dtsch Dermatol Ges 2019 Feb;17(2):214-230

Department of Dermatology, Mainz University Medical Center, Mainz, Germany.

Basal cell carcinoma (BCC) is the most common malignant tumor among fair-skinned individuals, and its incidence had been steadily rising in the past decades. In order to maintain the highest quality of patient care possible, the German S2k guidelines were updated following a systematic literature search and with the participation of all professional societies and associations involved in the management of the disease. Part 2 addresses issues such as proper risk stratification, the various therapeutic approaches, and prevention as well as follow-up of patients with basal cell carcinoma. Read More

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology and Skin Science, University of British Columbia.

Skin cancer is the most common human malignancy with an ongoing continual increase in global incidence. Despite their high prevalence, keratinocyte carcinomas (KCs), namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are often excluded from population-based cancer registries. As there are over 3000 defined skin disease varieties that can be diagnosed, robust ascertainment methods are needed to capture KC cases for epidemiologic purposes. Read More

Cell Death Dis 2019 Feb 13;10(2):143. Epub 2019 Feb 13.

LIM 64, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Protein disulfide isomerases including PDIA1 are implicated in cancer progression, but underlying mechanisms are unclear. PDIA1 is known to support vascular Nox1 NADPH oxidase expression/activation. Since deregulated reactive oxygen species (ROS) production underlies tumor growth, we proposed that PDIA1 is an upstream regulator of tumor-associated ROS. Read More

Cells 2019 Feb 12;8(2). Epub 2019 Feb 12.

Division of Medical Oncology, Hospital Sírio-Libanês, Brasilia, 70200-730, Brazil.

The Hedgehog pathway (HhP) plays an important role in normal embryonic development and its abnormal function has been linked to a variety of neoplasms. Recently, the complex mechanisms involved in this pathway have been deciphered and the cross talks with other important pathways involved in carcinogenesis have been characterized. This knowledge has led to the development of targeted therapies against key components of HhP, which culminated in the approval of vismodegib for the treatment of advanced basal cell carcinoma in 2012. Read More

Cutis 2019 Jan;103(1):E23-E25

Department of Dermatology, College of Medicine, Texas AM Health Science Center, and Baylor Scott and White Health, Temple, USA.

Cells 2019 Feb 11;8(2). Epub 2019 Feb 11.

Department of Molecular Medicine, Sapienza University, 00161 Rome, Italy.

Hedgehog (Hh) signaling is a critical developmental regulator and its aberrant activation,due to somatic or germline mutations of genes encoding pathway components, causes Basal CellCarcinoma (BCC) and medulloblastoma (MB). A growing effort has been devoted at theidentification of druggable vulnerabilities of the Hedgehog signaling, leading to the identificationof various compounds with variable efficacy and/or safety. Emerging evidence shows that anaberrant polyamine metabolism is a hallmark of Hh-dependent tumors and that itspharmacological inhibition elicits relevant therapeutic effects in clinical or preclinical models ofBCC and MB. Read More

Cells 2019 Feb 11;8(2). Epub 2019 Feb 11.

Laboratorio de Nefrología Experimental y Bioquímica Molecular, Instituto de Investigaciones Médicas "Alfredo Lanari", Facultad de Medicina, Universidad de Buenos Aires, 1427 Buenos Aires, Argentina.

Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple basal cell carcinomas (BCC), mainly caused by gene mutations. Our current study aimed to establish (1) germinal and somatic mutational status, (2) component and Hedgehog (HH) pathway targets gene expression patterns, and (3) profile variations according to the genetic background in BCC and normal surrounding skin (NSS). We collected 23 blood and 20 BCC patient samples and analyzed the gene using bidirectional sequencing and multiplex ligation-dependent probe amplification. Read More

Curr Health Sci J 2018 Apr-Jun;44(2):166-171. Epub 2018 Mar 27.

Department of Infant Care-Pediatrics-Neonatology, University of Medicine and Pharmacy of Craiova, Romania.

Basal cell carcinomas (BCCs) are malignant tumors with particular biological prognosis and behavior, and the biomolecular investigation of these lesions can provide important therapeutic targets for epithelial neoplasia. In this study we analyzed the immunoexpression of transforming growth factor beta 3 (TGFβ3) and its receptor type III (TGFβRIII) for 53 cases of BCC in relation to the main histopathological prognostic parameters. The results indicated statistically significant differences of TGFβ3 and TGFβRIII expression related to histological type and lesion stage, the both proteins being higher expressed in adenoid and morpheaform advanced stage tumors. Read More

Curr Treat Options Oncol 2019 Feb 11;20(2):13. Epub 2019 Feb 11.

Department of Dermatology, Keio University School of Medicine, Shinanomachi 35, Shinjuku, Tokyo, 160-8582, Japan.

Opinion Statement: Basal cell carcinomas (BCCs) are common skin cancers that tend to appear on sun-exposed skin. Pathobiologically, activation of the Hedgehog signaling pathway characterizes the majority of cases. In general, BCCs are slow-growing and rarely metastasize. Read More

Br J Clin Pharmacol 2019 Feb 10. Epub 2019 Feb 10.

Department of Medical Oncology, Azienda Ospedaliera Universitaria Integrata (AOUI), Verona, Italy.

Aims: Data regarding the cardiac toxicity of cabozantinib lacks. The aim of our study was to assess the risk of cabozantinib-related cardiotoxicity in mRCC patients.

Methods: We performed a multicenter prospective study on mRCC patients treated with cabozantinib between October 2016 and November 2017. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Feb;33(2):207-211

Department of Plastic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 330006, P.R.China.

Objective: To explore the effectiveness of modified rhomboid flap for repairing facial skin and soft tissue defect.

Methods: Between January 2016 and May 2018, 23 patients with facial skin and soft defect were repaired by the modified rhomboid flap. There were 10 males and 13 females with the median age of 27 years (range, 11-72 years). Read More

Br J Dermatol 2019 Feb 9. Epub 2019 Feb 9.

Department of Dermatology, ASST degli Spedali Civili, Spedali Civili di Brescia, Brescia, Italy.

Vismodegib is an Hedgehog Pathway Inhibitor Therapy (HPIT) for patients affected by Locally Advanced Basal Cell Carcinoma (laBCC) and Metastatic Basal Cell Carcinoma (mBCC) not eligible for surgery and/or radiotherapy . The efficacy of Vismodegib has been reported by several studies; likewise, treatment-emergent adverse effects (AEs) have been reported for 95-100% of the patients . It has been observed that patients who achieved complete or partial response often discontinued HPIT because of a grade 1 or 2 AEs. Read More

J Surg Oncol 2019 Feb 8. Epub 2019 Feb 8.

Department of Plastic Surgery and Hand Surgery, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.

Background And Objectives: Recent studies show that whole specimen intraoperative frozen section analysis (WIFSA) is a reliable method for margin analysis in basal cell carcinoma (BCC) and has low recurrence rates after five-years follow-up. There are no studies with longer follow-up. Our aim is to present long-term recurrence rates after WIFSA. Read More

BMJ Case Rep 2019 Feb 7;12(2). Epub 2019 Feb 7.

Department of Otolaryngology Head and Neck Surgery, St. James's Hospital, Dublin, Ireland.

We report an extremely rare case of a hybrid tumour of the maxillary sinus. A 51-year-old man presented with a 6-week history of nasal congestion and epiphora. Radiological imaging demonstrated a maxillary sinus tumour, with extensive local invasion. Read More

J Plast Reconstr Aesthet Surg 2018 Dec 25. Epub 2018 Dec 25.

Department of Plastic Surgery, Wake Forest Baptist Medical Center, 1 Medical Center Boulevard, Winston-Salem, NC 27157, United States.

Background: Forehead flap reconstruction of large nasal defects can be challenging. The senior author has used a paramedian forehead flap modification using the supratrochlear artery on the contralateral side of the defect.

Methods: A 9-year retrospective review (2008-2016) was performed for patients undergoing nasal reconstruction with the cross-paramedian forehead flap. Read More

Urology 2019 Feb 5. Epub 2019 Feb 5.

University of Kentucky College of Medicine, Lexington, KY; VA Medical Center, Lexington, KY. Electronic address:

Objective: To examine the relationship between phosphodiesterase 5 inhibitor drugs (PDE5i) and skin cancers in a large-scale study of Veterans.

Methods: This was a retrospective database review using the Department of Veterans Affairs Informatics and Computing Infrastructure database. Veterans Affairs Informatics and Computing Infrastructure was searched 19 years for Veterans who received PDE5i treatment of erectile dysfunction. Read More

Acta Otolaryngol 2019 Feb 8:1-6. Epub 2019 Feb 8.

a Department of Otolaryngology , Orebro Universitet Institutionen for Medicinska Vetenskaper, Örebro University Hospital , Örebro , Sweden.

Background: Electrochemotherapy (ECT) is a cancer treatment modality where the intracellular accumulation of chemotherapeutic agents is enhanced by an applied electrical field.

Aims/objectives: To evaluate the long-term efficacy, safety and functional outcome after ECT treatment in high-risk non-melanoma skin cancer (NMSC) with curative intent.

Materials And Methods: Seven patients with SCC or BCC in the head and neck area were treated with ECT with intratumoral bleomycin administration. Read More

J Pathol 2019 Feb 8. Epub 2019 Feb 8.

RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

In this Annual Review Issue of The Journal of Pathology, we present 15 invited reviews on topical aspects of pathology, ranging from the impacts of the microbiome in human disease through mechanisms of cell death and autophagy to recent advances in immunity and the uses of genomics for understanding, classifying and treating human cancers. Each of the reviews is authored by experts in their fields and our intention is to provide comprehensive updates in specific areas of pathology in which there has been considerable recent progress. Read More

J Am Acad Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Health Services and Systems Research, Duke-NUS Medical School, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Electronic address:

Background: While epidemiological studies in populations of European-descent suggest possible chemo-protective effect of caffeine against non-melanoma skin cancer (NMSC), data in Asian populations are lacking.

Objectives: We examined the relations between coffee, tea and caffeine consumption, and NMSC risk among Chinese in Singapore.

Methods: We used data from the Singapore Chinese Health Study, a prospective cohort of 63,257 men and women aged 45-74 years at recruitment from 1993 to 1998. Read More

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, University Hospital of Saint-Etienne, 42055 Saint-Etienne Cedex 2, France.

There are only case reports concerning dermoscopy of eyelid margin tumours. We evaluated the clinical and dermoscopic features of 165 eyelid margin tumours of 145 consecutive patients (77 females, 68 males, mean age 64·3 years, standard deviation - SD 17·94, range 10 - 95 years) recruited at the Dermatology Department of the University Hospital of Saint-Etienne, France, between September 1st, 2013 and January 30th, 2017 to exclude malignant tumours. This article is protected by copyright. Read More

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, University Hospital, Liebermeisterstraße 25, D-72076, Tuebingen.

The most common skin cancer is basal cell carcinoma (BCC). As the incidence of BCC is increasing, it is of major interest to optimize diagnostic and therapeutic options. The most effective option for complete clearance is through surgical treatment. Read More

Oncotarget 2019 Jan 15;10(5):573-583. Epub 2019 Jan 15.

Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.

At present, targeting PD-1/PD-L1 axis for immune checkpoint inhibition has improved treatment of various tumor entities, including head and neck squamous cell carcinoma (HNSCC). However, one part of the patient cohort still shows little improvement or even hyperprogression. We established three radioresistant (RR) and three radiosensitive (RS) HNSCC cell lines. Read More

An Bras Dermatol 2019 Jan-Feb;94(1):108-110

Dermatology Course, Department of Dermatology and Radiotherapy, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu (SP), Brazil.

An Bras Dermatol 2019 Jan-Feb;94(1):42-46

Service of Dermatology, Hospital Escola Álvaro Alvim, Campos dos Goytacazes (RJ), Brazil.

Background: Skin cancer is a highly prevalent condition with a multifactorial etiology resulting from genetic alterations, environmental and lifestyle factors. In Brazil, among all malignant tumors, skin cancers have the highest incidences.

Objective: To retrospectively evaluate the incidence, prevalence and profile of basal cell carcinoma, squamous cell carcinoma and cutaneous melanoma in Campos dos Goytacazes and region. Read More

JAMA Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, University of California, Irvine, Irvine, California.

JAMA Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

JAMA Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Scientific Advisory Committee, ACMS, Milwaukee, Wisconsin.

JAMA Dermatol 2019 Feb 6. Epub 2019 Feb 6.

The Skin Cancer Center, Cincinnati, Ohio.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, University of Naples Federico II, Naples, Italy.

We read with great interest the article entitled "Managing adverse effects by dose reduction during routine treatment of locally advanced basal cell carcinoma (laBCC) with the hedgehog inhibitor vismodegib: a single center experience" recently published in your journal and we want to report also our experience regarding the effect of dose reduction of hedgehog inhibitor vismodegib treatment as a new therapeutic option in order to reduce the high frequency of adverse events and increase patients compliance. This article is protected by copyright. All rights reserved. Read More

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Italy.

Adnexal tumors represent one of the most troublesome differential diagnosis when dealing with skin lesions with clinical and dermoscopic criteria suggestive for basal cell carcinoma (BCC). Among these, benign follicular tumors, and in particular trichoblastoma and trichoepithelioma, deserve a special mention as BCC mimickers. These are benign tumors showing differentiation toward the outer follicular sheath. Read More

Eur Rev Med Pharmacol Sci 2019 Jan;23(2):877-884

Department of Plastic Surgery, Henan Province Luoyang Orthopedic Thraumatological Hospital.

Objective: To investigate the effect of endostatin on the proliferation, invasion and epithelial-mesenchymal transition (EMT) of human basal cell carcinoma (BCC) cells (A431).

Patients And Methods: CCK-8 assay and transwell chamber assay were performed to detect cell proliferation and invasion abilities, respectively. Western blot was performed for the detection of the expressions of EMT-related proteins levels. Read More

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Human skin contains resident memory T cells (T ) and central memory T cells (T ) . T are characterized by CD69 expression and can be divided into 2 subpopulations: CD103 T and CD103 T . Although both T and T showed antitumor efficacy in a mouse model , little is known about their role in human skin cancer. Read More

J Skin Cancer 2019 3;2019:4876309. Epub 2019 Jan 3.

Department of Dermatology, Jordan University of Science and Technology, P.O. Box 3030, Irbid, Jordan.

Introduction: Basal cell carcinoma (BCC) is the most common cancer affecting humans. Luckily it has negligible risk for metastasis; however it can be locally destructive to surrounding tissue. The diagnosis of this tumor relies on clinical and dermoscopic features; however confirmation requires biopsy and histologic examination. Read More

J Healthc Eng 2019 3;2019:2784516. Epub 2019 Jan 3.

INKA Intelligente Katheter, Otto-von-Guericke-Universität Magdeburg, Magdenurg, Germany.

The efficiency of electroporation (EP) has made it a widely used therapeutic procedure to transfer cell killing substances effectively to the target site. A lot of researches are being done on EP-based cancer treatment techniques. Electrochemotherapy (ECT) is the first EP-based application in the field of drug administration. Read More

Cancer Med 2019 Feb 4. Epub 2019 Feb 4.

The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Nanjing, Jiangsu, China.

Long noncoding RNAs (lncRNAs) are aberrantly expressed in various cancers types and can function as competing endogenous RNAs (ceRNAs), which promote and maintain tumor initiation and progression. In this study, we explored the functional roles and regulatory mechanisms of lncRNAs as ceRNAs in colorectal cancer and their clinical potential as biomarkers. The RNA sequencing profiles of patients with colorectal cancer were downloaded from TCGA database, and 62 lncRNAs, 30miRNAs, and 59 mRNAs were identified to comprise the ceRNA network (fold change > 2, P < 0. Read More

Cell Stem Cell 2019 Jan 31. Epub 2019 Jan 31.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA; New York University School of Medicine, New York, NY, USA. Electronic address:

Basal tumor propagating cells (TPCs) control squamous cell carcinoma (SCC) growth by self-renewing and differentiating into supra-basal SCC cells, which lack proliferative potential. While transcription factors such as SOX2 and KLF4 can drive these behaviors, their molecular roles and regulatory interactions with each other have remained elusive. Here, we show that PITX1 is specifically expressed in TPCs, where it co-localizes with SOX2 and TRP63 and determines cell fate in mouse and human SCC. Read More

J Am Acad Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana; Indiana University Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana. Electronic address:

Background: The presence of nevi portends an increased risk for melanoma.

Objective: We sought to examine the association between extremity nevus count and the risk of melanoma and keratinocyte cancers.

Methods: We evaluated prospective cohorts of 176,317 women (the Nurses' Health Study, 1986-2012 and the Nurses' Health Study 2, 1989-2013) and 32,383 men (Health Professionals Follow-up Study, 1986-2012). Read More

Dermatol Online J 2019 Jan 15;25(1). Epub 2019 Jan 15.

The Thomas Jefferson University, Department of Dermatology, Philadelphia, Pennsylvania.

Koebnerization of pemphigus vulgaris (PV) is an infrequently reported reaction. We present a 65-year-old man with Koebnerized pemphigus vulgaris after Mohs microscopic surgery for a basal cell carcinoma. We present this case to heighten awareness of the phenomenon in the dermatological community. Read More

J Am Acad Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands; Department of Dermatology, Roosevelt Clinic, Leiden, the Netherlands. Electronic address:

Background: Mohs micrographic surgery (MMS) should lead to tissue sparing of healthy skin compared to standard surgical excision, because smaller surgical margins are used.

Objective: To quantify the tissue-sparing properties of MMS in primary basal cell carcinoma (BCC) with an infiltrative growth pattern.

Methods: A prospective study including 256 primary BCC with an infiltrative growth pattern was performed. Read More

J Invest Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, London E1 2AT, UK. Electronic address:

Keratinocyte skin cancer, comprising cutaneous squamous (cSCC) and basal cell carcinoma, is the most common malignancy in the UK. P53 is frequently mutated in cSCC. iASPP is a key inhibitor of p53 and NF-kB signalling pathways and has been documented as highly expressed in several types of human cancer. Read More

J Eur Acad Dermatol Venereol 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany.

The incidence of keratinocyte carcinoma (KC), which includes squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and actinic keratosis (AK), has steadily increased in the last few decades; moreover, KC is the most common malignancy in Caucasians worldwide. As exposure to solar ultraviolet radiation (UVR) is the main risk factor for KC, outdoor workers bear a high risk for KC. Therefore, SCC and AK were officially recognised as occupational diseases in Germany in 2015. Read More

J Invest Dermatol 2019 Jan 29. Epub 2019 Jan 29.

Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford CA, United States of America. Electronic address:

Basal cell carcinomas (BCCs) rely on Hedgehog (HH) pathway growth signal amplification by the microtubule-based organelle, the primary cilium. Despite naïve tumors responsiveness to Smoothened inhibitors (Smo), resistance in advanced tumors remains frequent. While the resistant BCCs usually maintain HH pathway activation, squamous cell carcinomas with Ras/MAPK pathway activation also arise, with the molecular basis of tumor type and pathway selection still obscure. Read More

J Clin Invest 2019 Feb 1;129(2):465-475. Epub 2019 Feb 1.

Department of Biochemistry and Biophysics, UCSF, San Francisco, California, USA.

The Hedgehog pathway is critical for the development of diverse organs. Misactivation of the Hedgehog pathway can cause developmental abnormalities and cancers, including medulloblastoma, the most common pediatric brain tumor, and basal cell carcinoma, the most common cancer in the United States. Here, we review how basic, translational, and clinical studies of the Hedgehog pathway have helped reveal how cells communicate, how intercellular communication controls development, how signaling goes awry to cause cancer, and how to use targeted molecular agents to treat both inherited and sporadic cancers. Read More