Search our Database of Scientific Publications and Authors

I’m looking for a

    25746 results match your criteria Basal Cell Carcinoma

    1 OF 515

    Guidelines of care for the management of basal cell carcinoma.
    J Am Acad Dermatol 2018 Jan 3. Epub 2018 Jan 3.
    Department of Family Medicine, University of Michigan School of Medicine, University of Michigan, Ann Arbor, Michigan.
    Basal cell carcinoma (BCC) is the most common form of human cancer, with a continually increasing annual incidence in the United States. When diagnosed early, the majority of BCCs are readily treated with office-based therapy, which is highly curative. In these evidence-based guidelines of care, we provide recommendations for the management of patients with BCC, as well as an in-depth review of the best available literature in support of these recommendations. Read More

    Noninvasive optical spectroscopy for identification of non-melanoma skin cancer: Pilot study.
    Lasers Surg Med 2018 Jan 13. Epub 2018 Jan 13.
    Division of Head and Neck Surgery and Communication Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina.
    Objective: Optical spectroscopy offers a noninvasive alternative to biopsy as a first-line screening tool for suspicious skin lesions. This study sought to define several optical parameters across malignant and benign tissue types.

    Study Design: Prospective pilot trial utilizing the Zenalux IM1 optical spectroscopy device from April 2016 to February 2017. Read More

    Chemical imaging of aggressive basal cell carcinoma using time-of-flight secondary ion mass spectrometry.
    Biointerphases 2018 Jan 12;13(3):03B402. Epub 2018 Jan 12.
    Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg 412 96, Sweden.
    A set of basal cell carcinoma samples, removed by Mohs micrographic surgery and pathologically identified as having an aggressive subtype, have been analyzed using time-of-flight secondary ion mass spectrometry (SIMS). The SIMS analysis employed a gas cluster ion beam (GCIB) to increase the sensitivity of the technique for the detection of intact lipid species. The GCIB also allowed these intact molecular signals to be maintained while surface contamination and delocalized chemicals were removed from the upper tissue surface. Read More

    Overcoming the resistance mechanisms of Smoothened inhibitors.
    Drug Discov Today 2018 Jan 8. Epub 2018 Jan 8.
    Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, China. Electronic address:
    Smoothened (Smo), the main transducer of the Hedgehog (Hh) signaling pathway, is a promising target for anticancer therapy. Although vismodegib and sonidegib have demonstrated effectiveness for the treatment of basal cell carcinoma (BCC), their clinical use has been associated with mutation-related drug resistance. In this review, we outline the resistance mechanisms of Smo inhibitors and point the way for future endeavors. Read More

    Use of antihypertensive drugs and risk of keratinocyte carcinoma: A meta-analysis of observational studies.
    Pharmacoepidemiol Drug Saf 2018 Jan 10. Epub 2018 Jan 10.
    Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
    Purpose: Current epidemiologic evidence on the association between antihypertensive drugs and keratinocyte carcinoma (KC) risk is inconsistent. We sought to quantify this association by meta-analysis of observational studies.

    Methods: We systematically reviewed observational studies published through August 2016 and reported the KC risk (basal cell carcinoma [BCC] and squamous cell carcinoma [SCC]) associated with antihypertensive drugs, including diuretics, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), beta-adrenergic blocking agents (β-blockers), and calcium channel blockers (CCBs). Read More

    Strategies to target the Hedgehog signaling pathway for cancer therapy.
    Med Res Rev 2018 Jan 5. Epub 2018 Jan 5.
    Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USA.
    Hedgehog (Hh) signaling is an essential pathway in the human body, and plays a major role in embryo development and tissue patterning. Constitutive activation of the Hh signaling pathway through sporadic mutations or other mechanisms is explicitly associated with cancer development and progression in various solid malignancies. Therefore, targeted inhibition of the Hh signaling pathway has emerged as an attractive and validated therapeutic strategy for the treatment of a wide range of cancers. Read More

    Nonmelanoma Skin Cancer Risk in Patients With Inflammatory Bowel Disease Undergoing Thiopurine Therapy: A Systematic Review of the Literature.
    Dermatol Surg 2018 Jan 8. Epub 2018 Jan 8.
    Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
    Background: Azathioprine and 6-mercaptopurine (thiopurines) are common adjunct treatments for inflammatory bowel disease (IBD). Although thiopurine therapy in organ transplant recipients is known to increase nonmelanoma skin cancers (NMSCs), dermatologic literature yields less data regarding NMSC risk of thiopurine use in IBD.

    Objective: The aim of this study was to systematically review current literature on NMSC risk in patients with IBD using thiopurine therapy. Read More

    The limitations of dermoscopy: false positive and false negative tumors.
    J Eur Acad Dermatol Venereol 2018 Jan 5. Epub 2018 Jan 5.
    First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
    Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumors, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically "false positive" and "false negative" tumors do exist. False positive diagnosis usually leads to unnecessary excisions. Read More

    Fisetin suppresses malignant proliferation in human oral squamous cell carcinoma through inhibition of Met/Src signaling pathways.
    Am J Transl Res 2017 15;9(12):5678-5683. Epub 2017 Dec 15.
    Department of Oromaxillofacial-Head and Neck Surgery, School of Stomatology, China Medical UniversityShenyang, Liaoning 110002, China.
    Fisetin (3,7,3',4'-tetrahydroxyflavone) is a dietary flavonoid and has been indicated as a novel anti-cancer agent in several types of cancer cells. However, the mechanisms underlying the effect of fisetin in human oral squamous cell carcinoma (OSCC) remain unclear. Here, we report that fisetin significantly inhibits tumor cell proliferation and induces apoptosis in OSCC (UM-SCC-23 and Tca-8113) cancer cell lines. Read More

    Never too old to regenerate? Wound induced hair follicle neogenesis after secondary intention healing in a geriatric patient?
    J Tissue Viability 2018 Jan 4. Epub 2018 Jan 4.
    Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
    Wound healing is a natural process to restore the structure and function of injured or diseased tissues. Repair of a skin wound usually leads to a scar while regeneration implies fully recovery of function and structure of the damaged tissue. Adult skin wound usually heals with scar while fetal skin heals scarless. Read More

    Case report repairing orbital skin defects using composite flaps after giant eyelid-derived tumor excision and orbital exenteration.
    Medicine (Baltimore) 2017 Dec;96(48):e8978
    Department of Ophthalmology, Second Hospital of JiLin University, ChangChun.
    Rationale: Though giant malignant tumors arising in the eyelid are rare, they often require extensive surgery for removal along with orbital exenteration. Because of this, repairing orbital defects is an important factor in the surgical strategy.

    Patient Concerns: Case 1 was a 78-year-old nomad man who presented in the Department of Ophthalmology with a giant tumor in his right eyelid, which had developed over three years. Read More

    Comparison of treatment of basal cell carcinoma between surgery and intralesional photodynamic therapy: a cross-sectional study.
    Photodiagnosis Photodyn Ther 2018 Jan 5. Epub 2018 Jan 5.
    Department of Dermatology, Complejo Asistencial Universitario de León, Spain.
    Background: Surgery is the treatment of choice in basal cell carcinoma (BCC), but new less invasive techniques are in development as photodynamic therapy. The main problem of this technique is the limited penetration. The use of an intralesional photosensitizer plus an irradiation with a 630 nm laser increased this penetration. Read More

    Medical Student Decision-Making: Standard Surgical Excision or Mohs Micrographic Surgery to Manage Basal Cell Carcinoma.
    J Am Osteopath Assoc 2018 Jan;118(1):19-25
    Context: As future physicians, osteopathic medical students will play a critical role in helping patients make informed decisions regarding treatment options.

    Objective: To examine the influence that the time, cost, and cosmetic effects associated with treatment options for basal cell carcinoma (BCC), along with students' demographic characteristics, have on treatment decision-making. The influence that different sources of information have on students was also studied. Read More

    Subsequent non-melanoma skin cancers and impact of immunosuppression in liver transplant recipients.
    J Am Acad Dermatol 2018 Jan 4. Epub 2018 Jan 4.
    Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Digestive Diseases, Lyon, France; Université Claude Bernard Lyon 1, Lyon, France. Electronic address:
    Background: Non-melanoma skin cancers (NMSC) are the most frequent cancers in solid organ transplant recipients, with a high rate of subsequent tumors.

    Objectives: To describe subsequent NMSC in a large cohort of liver transplant recipients (LTR) with long follow-up, and to analyze the factors influencing it, including immunosuppressive regimen.

    Methods: Ninety-eight LTR (76 male) with a personal post-transplant history of squamous-cell carcinoma (SCC), basal-cell carcinoma (BCC) or Bowen's disease were included, with a median follow-up of 12. Read More

    Predictive value of basal cell carcinoma biopsies with negative margins: A retrospective cohort study.
    J Am Acad Dermatol 2018 Jan 4. Epub 2018 Jan 4.
    Department of Dermatology, San Antonio Military Medical Center, San Antonio, TX. Electronic address:
    Background: Pathology reports of basal cell carcinoma (BCC) biopsies often contain comments of positive or negative margins, with only 1-2% of the margin evaluated. The negative predictive value (NPV) of biopsy margin status on residual BCC is unknown.

    Objective: The purpose of this study was to determine the NPV of BCC biopsy margin status on the absence of residual BCC in the corresponding excision. Read More

    Superiorly based nasolabial island flap for reconstruction of the lateral lower eyelid
    Turk J Med Sci 2017 Dec 19;47(6):1673-1680. Epub 2017 Dec 19.
    Background/aim: Various flap procedures have been described and used for the lower eyelids; however, the nasolabial flap is rarely employed. We herein aimed to present the clinical results of using the superiorly based nasolabial island flap for repair of surgical defects extending to the lateral lower eyelid. Materials and methods: Nine patients with a mean age of 62 +- 6 years underwent surgery for reconstruction of the lower eyelid. Read More

    [Complete treatment of basal cell carcinoma; cost effectiveness of Mohs micrographic surgery versus conventional excision].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1549
    Mohs Klinieken, Dordrecht-Amsterdam-Hoorn.
    Objective: To investigate whether Mohs micrographic surgery (MMS) in accordance with the indications in the revised guideline on basal cell carcinoma (BCC) more often leads to complete treatment than conventional excision (CE) and whether the costs are comparable, and to analyse whether this also applies to all primary BCC of the face.

    Design: Retrospective analysis.

    Method: We gathered data on 3374 MMS procedures and calculated per localisation, subtype and size: the percentage of CE that would have been incomplete after applying the recommended surgical margin; the surgical margin necessary to achieve complete excision in > 90% of cases; the final defect after CE and after MMS; the cost of MMS and the cost of CE with postponed reconstruction or, in the case of incomplete CE, subsequent MMS. Read More

    Non Melanoma Skin Cancer Pathogenesis Overview.
    Biomedicines 2018 Jan 2;6(1). Epub 2018 Jan 2.
    Department of Dermatology, Sapienza Università di Roma, Rome 00100, Italy.
    (1) Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood. However, several studies have been conducted to better explain the mechanisms that lead to malignancy; (2) Methods: We reviewed the more recent literature about the pathogenesis of non-melanoma skin cancer focusing on basal cell carcinomas, squamous cell carcinoma and actinic keratosis; (3) Results: Several papers reported genetic and molecular alterations leading to non-melanoma skin cancer. Read More

    Chemoprevention of Basal and Squamous Cell Carcinoma With a Single Course of Fluorouracil, 5%, Cream: A Randomized Clinical Trial.
    JAMA Dermatol 2018 Jan 3. Epub 2018 Jan 3.
    Cooperative Studies Program Central Office, Washington, DC.
    Importance: Keratinocyte carcinoma (ie, cutaneous basal and squamous cell carcinoma) is the most common cancer in the United States.

    Objective: To determine whether topical fluorouracil could prevent surgically treated keratinocyte carcinoma.

    Design, Setting, And Participants: The Veterans Affairs Keratinocyte Carcinoma Chemoprevention Trial was a randomized, double-blind, placebo-controlled trial of topical fluorouracil for chemoprevention of keratinocyte carcinoma. Read More

    Automated multimodal spectral histopathology for quantitative diagnosis of residual tumour during basal cell carcinoma surgery.
    Biomed Opt Express 2017 Dec 22;8(12):5749-5766. Epub 2017 Nov 22.
    School of Physics and Astronomy, University Park, University of Nottingham, Nottingham, NG7 2RD, UK.
    Multimodal spectral histopathology (MSH), an optical technique combining tissue auto-fluorescence (AF) imaging and Raman micro-spectroscopy (RMS), was previously proposed for detection of residual basal cell carcinoma (BCC) at the surface of surgically-resected skin tissue. Here we report the development of a fully-automated prototype instrument based on MSH designed to be used in the clinic and operated by a non-specialist spectroscopy user. The algorithms for the AF image processing and Raman spectroscopy classification had been first optimised on a manually-operated laboratory instrument and then validated on the automated prototype using skin samples from independent patients. Read More

    SREBP-2-driven transcriptional activation of human SND1 oncogene.
    Oncotarget 2017 Dec 21;8(64):108181-108194. Epub 2017 Nov 21.
    Lipids & Liver Research Group, Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Barrio Sarriena s/n, 48940 Leioa, Vizcaya, Spain.
    Upregulation of Staphylococcal nuclease and tudor domain containing 1 (SND1) is linked to cancer progression and metastatic spread. Increasing evidence indicates that SND1 plays a role in lipid homeostasis. Recently, it has been shown that SND1-overexpressing hepatocellular carcinoma cells present an increased de novo cholesterol synthesis and cholesteryl ester accumulation. Read More

    Cutaneous Metaplastic Carcinoma: Report of a Case With Sebaceous Differentiation.
    Am J Dermatopathol 2017 Dec 28. Epub 2017 Dec 28.
    Department of Dermatology, Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP), São Paulo, Brazil.
    In this study, a case of a 56-year-old woman with cutaneous metaplastic carcinoma in the neck is reported. It harbored basal cell carcinoma, squamous cell carcinoma, and sebaceous carcinoma, as well as osteosarcoma (with fibroblastic, osteoblastic, aneurysmal bone cyst-like, and chondroblastic patterns). To our knowledge, the literature does not mention sebaceous carcinoma in cutaneous metaplastic carcinoma. Read More

    Comparison of skin cancers in liver and renal transplant recipients: Results of a prospective study in an Australian tertiary referral centre.
    Australas J Dermatol 2018 Jan 2. Epub 2018 Jan 2.
    Department of Dermatology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
    Background/objectives: Organ transplant recipients (OTR) have an increased risk of skin cancers compared with the general population.

    Methods: A prospective study of renal (RTR) and liver transplant recipients (LTR) was conducted in a single New South Wales tertiary referral centre over 60 months. Initial and subsequent visit data were recorded in our transplant database. Read More

    Assessment of singlet oxygen dosimetry concepts in photodynamic therapy through computational modeling.
    Photodiagnosis Photodyn Ther 2017 Dec 29. Epub 2017 Dec 29.
    Physics Department, Laboratory of "Optoelectronics and Laser Applications", National Technical University of Athens, Zografou Campus, 15780, Athens, Greece.
    Background: In photodynamic therapy (PDT) oxygen plays vital role in killing tumor cells and therefore its dosimetry is being thoroughly studied.

    Methods: Light distribution into tissue is modelled for radiation-induced fibrosarcoma (RIF) and nodular basal cell carcinoma (nBCC), in order to study the influence of blood flow on singlet oxygen concentration effectively leading to cell death ([1O2]rx) on PDT, within this light distribution. This is achieved through initial oxygen supply rate (g0) and initial molecular oxygen concentration ([3O2]0) calculations. Read More

    New Combination Strategy of Photodynamic Therapy and Surgery in Treating Recurrent Basal Cell Carcinoma, a Case Report.
    Photodiagnosis Photodyn Ther 2017 Dec 27. Epub 2017 Dec 27.
    Department of Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Harvard Medical School, MA, USA.
    Background: There are several options for BCC treatment. But sometimes, even Mohs surgery isn't desirable because of predicted aggressive surgery. Treatment of recurrent basal cell carcinoma can be a challenge for dermatologists. Read More

    Intratarsal Keratinous Eyelid Cysts in Gorlin Syndrome: A Review and Reappraisal.
    Surv Ophthalmol 2017 Dec 26. Epub 2017 Dec 26.
    Ophthalmic Plastic and Reconstructive Surgery Service, Department of Ophthalmology of the Massachusetts Eye and Ear Infirmary and the Harvard Medical School, Boston, MA.
    A 38-year-old woman presented with multiple bilateral recurrent eyelid cysts. Her medical history was notable for Gorlin (nevoid basal cell carcinoma) syndrome. Histopathologic and immunohistochemical examinations revealed that the lesions were intratarsal keratinous cysts. Read More

    Correlation of telomere length to malignancy potential in non-melanoma skin cancers.
    Oncol Lett 2018 Jan 26;15(1):393-399. Epub 2017 Oct 26.
    Department of Dermatology, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
    Telomeres are associated with cell fate and aging through their role in the cellular response to stress and growth stimulation resulting from previous cell divisions and DNA damage. Telomere shortening has been observed in most human cancers, and is known to be a feature of malignancy. The aim of this study is to clarify whether telomere length is related to the malignant potential of non-melanoma skin cancers. Read More

    Identification of Felis catus papillomavirus 3 in skin neoplasms from four cats.
    J Vet Diagn Invest 2017 Dec 1:1040638717750852. Epub 2017 Dec 1.
    Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand (Munday, Thomson).
    Bowenoid in situ carcinomas (BISCs) are papillomavirus (PV)-induced skin neoplasms that are thought to be caused by Felis catus papillomavirus (FcaPV) 2. As BISCs are typically multiple and can become extensive, they can be difficult to treat. Herein we describe 4 cats that developed skin neoplasms that contained FcaPV-3 DNA. Read More

    Efficient Cancer Detection Using Multiple Neural Networks.
    IEEE J Transl Eng Health Med 2017 15;5:2800607. Epub 2017 Nov 15.
    Aurora Sinai Medical CenterNovascan Inc.
    The inspection of live excised tissue specimens to ascertain malignancy is a challenging task in dermatopathology and generally in histopathology. We introduce a portable desktop prototype device that provides highly accurate neural network classification of malignant and benign tissue. The handheld device collects 47 impedance data samples from 1 Hz to 32 MHz via tetrapolar blackened platinum electrodes. Read More

    Carcinoma Cuniculatum of the Right Thenar Region with Bone Involvement and Lymph Node Metastases.
    Case Rep Dermatol 2017 Sep-Dec;9(3):225-230. Epub 2017 Nov 10.
    Department of Dermatology, Municipal Hospital Hietzing, Vienna, Austria.
    Squamous cell carcinoma (SCC) is the second most common type of skin cancer after basal cell carcinoma (BCC). The overall prevalence of BCC is 3 times higher than that of SCC, but this can vary when looking at specific locations such as the hand, where SCC is much more common than BCC. Carcinoma (or epithelioma) cuniculatum is a rare variant of SCC. Read More

    Treatment of Multiple Actinic Keratosis and Field of Cancerization with Topical Piroxicam 0.8% and Sunscreen 50+ in Organ Transplant Recipients: A Series of 10 Cases.
    Case Rep Dermatol 2017 Sep-Dec;9(3):211-216. Epub 2017 Oct 20.
    Department of Systems Medicine, Division of Dermatology, University of Rome Tor Vergata, Rome, Italy.
    Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Read More

    Metastatic Basal Cell Carcinoma: A Rare Manifestation of a Common Disease.
    Case Rep Med 2017 27;2017:8929745. Epub 2017 Nov 27.
    Department of Pathological Anatomy, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
    Introduction: Basal cell carcinoma (BCC) is considered the most common malignancy in Caucasians. It constituted about 80% of all nonmelanoma skin tumors and, despite its high prevalence, is an extremely rare occurrence of metastases, with incidence rates varying from 0.0028% to 0. Read More

    Metachronous Development of Meningothelial Meningioma, Basal Cell Carcinoma, and Glioblastoma Multiforme in a Patient with Pancreatic Incidentaloma.
    Case Rep Oncol 2017 Sep-Dec;10(3):1023-1028. Epub 2017 Nov 16.
    Department of Medical Genetics, Medical University, Sofia, Bulgaria.
    We report the unique case of a 61-year-old male patient with known pancreatic incidentaloma who additionally developed 3 other histologically different tumors: left sphenoid wing meningothelial meningioma, basal cell carcinoma of the occiput, and right occipital lobe glioblastoma multiforme. The latter were totally removed with a favorable clinical outcome. The patient's family history was unremarkable, and no data on any previous head and neck irradiation were found. Read More

    A Case of Metastatic Basal Cell Carcinoma Treated with Cisplatin and Adriamycin.
    J Nippon Med Sch 2017 ;84(6):286-290
    Department of Dermatology, Nippon Medical School.
    A 72-year-old man was referred to our hospital for treatment of an ulcer that had been growing on his back for 10 years. Physical examination showed an ulcerated tumor from the neck to the back and swollen cervical lymph nodes. The tumor size was 12×9 cm. Read More

    Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague-Dawley rats.
    Regul Toxicol Pharmacol 2017 Dec 24;92:382-389. Epub 2017 Dec 24.
    Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:
    Vismodegib (also known as GDC-0449) is a novel small molecule inhibitor of the Hedgehog (Hh) signaling pathway currently approved for the treatment of metastatic or locally advanced basal cell carcinoma (BCC) in humans. Its tumorigenic potential was assessed in dedicated carcinogenicity studies in rasH2 transgenic (Tg.rasH2) mice and Sprague Dawley (SD) rats. Read More

    PTCH1 Germline Mutations and the Basaloid Follicular Hamartoma Values in the Tumor Spectrum of Basal Cell Carcinoma Syndrome (NBCCS).
    Anticancer Res 2018 01;38(1):471-476
    Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
    Background/aim: Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominantly inherited disorder characterized by multiple basal cell carcinomas (BCC), odontogenic tumors and various skeletal anomalies. Basaloid follicular hamartomas (BFHs) constitute rare neoplasms that can be detected in sporadic and familial settings as in the Basaloid Follicular Hamartoma Syndrome (BFHS). Although BFHS shares clinical, histopathological and genetic overlapping with the NBCCS, they are still considered two distinctive entities. Read More

    A real-world, community-based cohort study comparing the effectiveness of topical fluoruracil vs. topical imiquimod for the treatment of actinic keratosis.
    J Am Acad Dermatol 2017 Dec 22. Epub 2017 Dec 22.
    Division of Research, Kaiser Permanente Northern California, Oakland, CA; Department of Dermatology, Massachusetts General Hospital, and Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA. Electronic address:
    Background: The most widely used topical agents for the field-based treatment of multiple actinic keratoses (AKs) are 5-fluorouracil and imiquimod, but their comparative effectiveness has not been assessed in a real-world setting.

    Objective: We compared the effectiveness of 5-fluorouracil and imiquimod in reducing risk of subsequent AKs in a large, integrated healthcare delivery system in Northern California.

    Methods: In this cohort study, we identified adult health plan members that had an AK diagnosed in 2007 and subsequently filled a prescription for 5-fluorouracil or imiquimod (n=5,700). Read More

    Rituximab maintenance versus observation following abbreviated induction with chemoimmunotherapy in elderly patients with previously untreated chronic lymphocytic leukaemia (CLL 2007 SA): an open-label, randomised phase 3 study.
    Lancet Haematol 2017 Dec 20. Epub 2017 Dec 20.
    UPMC GRC11-GRECHY, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France.
    Background: Most patients with chronic lymphocytic leukaemia relapse after initial therapy combining chemotherapy with rituximab. We assessed the efficacy and safety of rituximab maintenance treatment versus observation for elderly patients in remission after front-line abbreviated induction by fludarabine, cyclophosphamide, and rituximab (FCR).

    Methods: This randomised, open-label, multicentre phase 3 trial at 89 centres in France enrolled treatment-naive and fit patients aged 65 years or older with chronic lymphocytic leukaemia without del(17p). Read More

    The role of the Hedgehog signaling pathway in cancer: A comprehensive review.
    Bosn J Basic Med Sci 2017 Dec 23. Epub 2017 Dec 23.
    Department of Biology, School of Medicine, University of Zagreb, Zagreb, Croatia.
    The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It is a highly conserved evolutionary pathway of signal transmission from the cell membrane to the nucleus. The Hh signaling pathway plays an important role in the embryonic development. Read More

    Absence of BRAFV600E mutation in odontogenic keratocysts.
    J Oral Pathol Med 2017 Dec 22. Epub 2017 Dec 22.
    Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
    Background: Mutations in the patched 1 (PTCH1) gene are the main genetic alteration reported in sporadic and nevoid basal cell carcinoma-associated odontogenic keratocyst (OKC). Oncogenic mutations, including BRAFV600E, previously considered exclusive of malignant neoplasms have been reported in odontogenic tumors. Recently, a high frequency of BRAFV600E mutation has been reported in OKC. Read More

    Reclassification and treatment of odontogenic keratocysts: A cohort study.
    Braz Oral Res 2017 Dec 18;31:e98. Epub 2017 Dec 18.
    Universidade de São Paulo - USP, School of Dentistry, Department of Oral & Maxillofacial Surgery, Traumatology and Prosthesis, São Paulo, SP, Brazil.
    The odontogenic keratocyst (OKC) is a recurrent cyst that has been recently reclassified from an odontogenic tumor to an odontogenic cyst. The aim of the present study was to investigate its treatment and address issues related to its association with nevoid basal cell carcinoma syndrome (NBCCS). Lesions from the cohort of patients included in the present study consisted of 40 OKCs, of which 27 lesions were treated by enucleation (GE) and 13 underwent decompression (GD). Read More

    Trigeminal trophic syndrome simulating rodent ulcer basal cell carcinoma: a new clinico-dermoscopic approach.
    An Bras Dermatol 2017 ;92(5 Suppl 1):148-150
    Department of Dermatology. Hospital Universitario Central de Asturias, Oviedo, Spain.
    Trigeminal trophic syndrome is an uncommon cause of facial ulcers, that affects the sensitive area of the trigeminal nerve. We present the case of an 84-year-old patient with ulcerated facial trigeminal trophic syndrome, and report the development of a clinico-dermoscopic approach for his clinical examination. The value of this model for the diagnosis of facial ulcers suspected to be a rodent ulcer basal cell carcinoma is suggested. Read More

    Melanoma in situ and syringoma: a rare collision tumor. Clinical-pathological report of a case.
    An Bras Dermatol 2017 ;92(5 Suppl 1):101-103
    Department of Dermatology. Hospital Universitari Sagrat Cor, Barcelona, Spain.
    Collision or contiguous tumors, defined as two or more distinct tumors occurring at one site, are often an unexpected finding and may represent a diagnostic challenge, as clinical and histological presentations do not always coincide. Various combinations of collision tumors have been described with respect to melanocytic lesions, with the most frequently reported being the combination of nevus and basal cell carcinoma. We present an unusual case on the nose involving a melanoma in situ and a clinically-inapparent syringoma, which, to the best of our knowledge, is the first report of this combination. Read More

    Inter-rater and intra-rater agreement of confocal microscopy imaging in diagnosing and subtyping basal cell carcinoma.
    J Eur Acad Dermatol Venereol 2017 Dec 19. Epub 2017 Dec 19.
    Academic Medical Center, Department of Dermatology, Amsterdam, The Netherlands.
    Background: Reflectance confocal microscopy (RCM) imaging can be used to diagnose and subtype basal cell carcinoma (BCC) but relies on individual morphologic pattern recognition that might vary among users.

    Objectives: We assessed the inter-rater and intra-rater agreement of RCM in correctly diagnosing and subtyping BCC.

    Methods: In this prospective study we evaluated the inter-rater and intra-rater agreement of RCM on BCC presence and subtype among three raters with varying experience who independently assessed static images of 48 RCM cases twice with four weeks interval (T1 and T2). Read More

    1 OF 515