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    Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the milan system for reporting salivary gland cytopathology.
    Cancer Cytopathol 2018 Apr 18. Epub 2018 Apr 18.
    Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona.
    Background: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. Read More

    EZH2 Expression in Naturally Occurring Canine Tumors.
    Comp Med 2018 Apr;68(2):148-155
    University of Ulsan College of Medicine, Asan Institute for Life Sciences, and Department of Pathology, Asan Medical Center, Seoul, Korea., Email:
    Enhancer of zeste homolog 2 (EZH2) shows upregulated expression in tumors and is an important driver of tumor development and progression. However, the mechanism underlying the mediation of tumor aggressiveness by EZH2 remains unclear. We here investigated the levels of EZH2 in various normal and tumorous dog tissues and compared these patterns with those of the corresponding human tissues. Read More

    MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function.
    Oncogene 2018 Apr 17. Epub 2018 Apr 17.
    Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, 310058, China.
    Hedgehog (Hh) pathway plays a pivotal role in diverse aspects of development and postnatal physiology. Perturbation of Hh signaling and activation of GLI1 (glioma-associated oncogene 1), a dedicated transcription factor for Hh pathway, are highly associated with several cancers, such as medulloblastoma and basal cell carcinoma. Dynamic and precise control of GLI1 activity is thus important to ensure proper homeostasis and tumorigenesis. Read More

    Cutaneous Head and Neck Malignancies in the Elderly.
    Clin Geriatr Med 2018 May 17;34(2):245-258. Epub 2018 Feb 17.
    Otolaryngology-Head and Neck Surgery, Head and Neck-Microvascular Surgery, Clinical Affairs, Indiana University School of Medicine, Fesler Hall, 1130 W. Michigan Street, Suite 400, Indianapolis, IN 46202, USA.
    Cutaneous malignancy of the head and neck affects a large proportion of elderly patients. The severity ranges from small, easily treatable lesions to large, invasive, potentially metastatic tumors. Surgical treatment is the primary treatment of most skin cancers; however, geriatric patients are more likely to have multiple comorbidities that increase the risk of surgery. Read More

    MUSE (Microscopy with UV Surface Excitation): a novel approach to real-time inexpensive slide free dermatopathology.
    J Cutan Pathol 2018 Apr 16. Epub 2018 Apr 16.
    Department of Pathology and Laboratory Medicine, University of California, Sacramento, CA, USA.
    Traditional histology relies on processing and physically sectioning either frozen or formalin-fixed, paraffin-embedded (FFPE) tissue into thin slices (typically 4-6 microns) prior to staining and viewing on a standard wide-field microscope. MUSE represents a novel alternative microscopy method that works with ultraviolet (UV) excitation using oblique cis-illumination which can generate high-quality images from the cut surface of fresh or fixed tissue after brief staining, with no requirement for fixation, embedding and histological sectioning of tissue specimens. We examined its potential utility in dermatopathology. Read More

    Familial Syndromes Involving Meningiomas Provide Mechanistic Insight Into Sporadic Disease.
    Neurosurgery 2018 Apr 11. Epub 2018 Apr 11.
    Vivian L. Smith Department of Neurosur-gery, University of Texas Health Science Center at Houston, Texas.
    Currently, there is an incomplete understanding of the molecular pathogenesis of meningiomas, the most common primary brain tumor. Several familial syndromes are characterized by increased meningioma risk, and the genetics of these syndromes provides mechanistic insight into sporadic disease. The best defined of these syndromes is neurofibromatosis type 2, which is caused by a mutation in the NF2 gene and has a meningioma incidence of approximately 50%. Read More

    PGE /EP antagonism enhances tumor chemosensitivity by inducing extracellular vesicle-mediated clearance of cancer stem cells.
    Int J Cancer 2018 Apr 15. Epub 2018 Apr 15.
    Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli 35053, Taiwan.
    Cells expressing mesenchymal/basal phenotypes in tumors have been associated with stem cell properties. Cancer stem cells (CSCs) are often resistant to conventional chemotherapy. We explored overcoming mesenchymal CSC resistance to chemotherapeutic agents. Read More

    FACE-Q Skin Cancer Module for Measuring Patient-Reported Outcomes Following Facial Skin Cancer Surgery.
    Br J Dermatol 2018 Apr 14. Epub 2018 Apr 14.
    Plastic and Reconstructive Surgery Division, Brigham and Women's Hospital, Boston, MA, USA.
    Background: The patient's perspective of their facial scar after skin cancer surgery influences perception of care and quality of life. Appearance satisfaction after surgery is also an important but often overlooked treatment outcome.

    Objectives: To report the psychometric validation of the FACE-Q Skin Cancer Module consisting of 5 scales measuring appearance satisfaction (Satisfaction with Facial Appearance, Appraisal of Scars), quality of life (Cancer Worry, Appearance-related Psychosocial Distress) and the patient experience (Satisfaction with Information: Appearance). Read More

    Deregulation of LIMD1-VHL-HIF-1α-VEGF pathway is associated with different stages of cervical cancer.
    Biochem J 2018 Apr 13. Epub 2018 Apr 13.
    Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata-700026, West Bengal, India, Kolkata, India
    To understand the mechanism of cellular stress in basal-parabasal layers of normal-cervix and during different stages of cervical carcinoma, we analyzed the alterations (expression/methylation/copy-number variation/mutation) of HIF-1α and its associated genes LIMD1, VHL and VEGF in disease free normal-cervix (n=9), adjacent normal-cervix of tumors (n=70), CIN (n=32), CACX (n=174) samples and two CACX cell lines. In basal-parabasal layers of normal-cervix, LIMD1 showed high protein-expression while low protein expression of VHL was concordant with high expression of HIF-1α and VEGF irrespective of HPV16 infection. This was in concordance with the low promoter methylation of LIMD1 and high in VHL in the basal-parabasal layers of normal-cervix. Read More

    In Vitro Anticancer Activity of Staphyloxanthin Pigment Extracted from KX912244, a Gut Microbe of .
    Indian J Microbiol 2018 Jun 16;58(2):146-158. Epub 2018 Mar 16.
    Department of Biotechnology and Microbiology, Karnatak University, Dharwad, 580003 Karnataka India.
    The present study reports the in vitro biological nature of the pigment produced by KX912244, isolated as the gut microflora bacterium of the insect . The purified pigment was characterized as Staphyloxanthin based on bio-physical characterization techniques like Fourier transform infrared spectroscopy, high performance liquid chromatography, Proton nuclear magnetic resonance spectroscopy (H NMR), Liquid chromatography-Mass spectroscopy and Gas chromatography-Mass spectroscopy. The Staphyloxanthin pigment presented considerable biological properties including in vitro antimicrobial activity against pathogens , and ; in vitro antioxidant activity by % DPPH free radical scavenging activity showing IC value of 54. Read More

    Nonvenereal Penile Dermatoses: A Retrospective Study.
    Indian Dermatol Online J 2018 Mar-Apr;9(2):96-100
    University Clinic of Dermatology, Hospital de Santa Maria, Lisbon, Portugal.
    Context: A variety of nonvenereal diseases can affect the penis and diminish quality of life. Many present similar clinical features and a cutaneous biopsy may be necessary to clarify the diagnosis.

    Aims: To characterize nonvenereal penile dermatoses with histological confirmation in a southwestern Europe hospital during a 9-year period. Read More

    An anterolateral thigh chimeric flap for dynamic facial and esthetic reconstruction after oncological surgery in the maxillofacial region: a case report.
    Head Face Med 2018 Apr 11;14(1). Epub 2018 Apr 11.
    Department of Oral and Maxillofacial Surgery, University of Szeged, Kálvária 57, Szeged, H-6725, Hungary.
    Background: The surgical management of malignant tumors in the head and neck region often leads to functional and esthetic defects that impair the quality of life of the patients. Reconstruction can be solved with prostheses in these cases, but various types of microsurgical free flaps can provide a better clinical outcome.

    Case Presentation: In this case report, the tumor and parts of the involved facial muscles and nerve were excised surgically from a 42-year-old patient after a third relapse of basal cell carcinoma in the left midface. Read More

    Clinicopathological significance of cystatin A expression in progression of esophageal squamous cell carcinoma.
    Medicine (Baltimore) 2018 Apr;97(15):e0357
    Department of Gastroenterology, The Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba.
    We previously conducted transcriptome analysis of a paired specimen of normal and esophageal squamous cell carcinoma (ESCC) tissues and found that mRNA expression of cystatin A (CSTA), a member of the cystatin superfamily, was perturbed in tumors compared with that in the background mucosa. However, little is known about the significance of CSTA expression in ESCC.The mRNA expression of CSTA was evaluated by qRT-PCR using 28 paired frozen samples of tumor and nontumor mucosae. Read More

    Periungual basal cell carcinoma.
    An Bras Dermatol 2018 Jan-Feb;93(1):114-115
    Dermatology Service at Hospital Naval Marcílio Dias (HNMD) - Rio de Janeiro (RJ), Brazil.
    Periungual basal cell carcinoma is rare and needs to be differentiated from other common diseases that affect this region. Several factors are associated with the development of this tumor, and sun damage seems to play an important role in its pathogenesis. Dermoscopy of clinically indolent lesions on the nail unit can shorten the diagnostic process and avoid destructive treatment and functional damage. Read More

    Pigmented squamous cell carcinoma: case report and importance of differential diagnosis.
    An Bras Dermatol 2018 Jan-Feb;93(1):96-98
    Division of Surgery at Fundação Alfredo da Matta (FUAM) - Manaus (AM), Brazil.
    A few cases of pigmented squamous cell carcinoma affecting the skin and the ocular and oral mucosa of the elderly have been described in the literature. The disease manifests itself as papular and nodular erythematous or pigmented lesions. The main clinical differential diagnoses are pigmented basal cell carcinoma and melanoma. Read More

    Fat intake and risk of skin cancer in US adults.
    Cancer Epidemiol Biomarkers Prev 2018 Apr 10. Epub 2018 Apr 10.
    Department of Dermatology, Brown University
    Background: Fat intake has been associated with certain cancers, including colorectal, breast, and prostate cancers. However, literature on dietary fat and skin cancer has been limited.

    Methods: We examined the association between fat intake and risk of skin cancer including cutaneous malignant melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) within two prospective studies; the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Read More

    Infiltrative basal cell carcinoma mimicking tinea corporis.
    Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
    Department of Dermatology, Baylor College of Medicine, Houston, Texas.
    The diagnosis of infiltrative basal cell carcinoma (BCC) can be delayed owing to its often subtle clinical findings. A 90-year-old woman presented with an asymptomatic annular pink plaque on her left shin that was clinically diagnosed as tinea corporis. After years of not responding to topical anti-fungal therapy, biopsies confirmed a diagnosis of infiltrative BCC. Read More

    Conjunctival Lesions: When Should We Perform Biopsy?
    Nepal J Ophthalmol 2017 Jul;9(18):160-169
    Introduction: The conjunctiva is a thin and flexible mucus membrane that provides a protective barrier for the eye. Very few histopathologic studies have been conducted on biopsies from conjunctival lesions (CL) in central India.

    Objective: To study the spectrum of CL and define those lesions that need attention with regard to need of biopsy in order to prevent grave sequelae and ocular morbidity. Read More

    Accuracy of dermoscopic criteria for the differentiation between superficial basal cell carcinoma and Bowen's disease.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
    Background: The dermoscopic features of superficial basal cell carcinoma (sBCC) and Bowen's disease (BD) have been extensively investigated and dermoscopy was shown to significantly improve their recognition. However, incorrectly diagnosed cases still exist, with a considerable number of sBCCs dermoscopically interpreted as BD. Our aim was to investigate the dermoscopic variability of sBCC and BD on different anatomic sites, to identify potent dermoscopic predictors for each diagnosis and to investigate the potential source of the inaccurate clinico-dermoscopic diagnosis of some sBCCs. Read More

    Laser-assisted photodynamic therapy for superficial basal cell carcinoma and Bowen's Disease: a randomised intra-patient comparison between a continuous and a fractional ablative CO laser mode.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Dermatology, Ghent University Hospital, Belgium.
    Background: Laser-assisted photodynamic therapy is being explored as a method to enhance efficacy of photodynamic therapy (PDT).

    Objective: To compare a continuous (CL) and a fractional (FL) ablative CO laser-assisted methyl aminolevulinate PDT in the management of superficial basal cell carcinoma (sBCC) and Bowen's Disease (BD).

    Methods: Thirty treatment areas in fifteen patients with inoperable, histologically verified sBCC or BD, received CL or FL after intra-patient randomisation. Read More

    Basal cell carcinoma: the utility of in vivo and ex vivo confocal microscopy.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy.
    The use of confocal microscopy is possible by using two different modalities: first, at patient's bedside for a rapid in vivo diagnosis of basal cell carcinoma and second, in the operating room directly on freshly excised specimen for a fast ex vivo margin controlled surgery. In the current review we report the main application of confocal microscopy for basal cell carcinoma diagnosis and management in both modalities. This article is protected by copyright. Read More

    EZH2 Expression in Naturally Occurring Canine Tumors.
    Comp Med 2019 Mar;68(2):148-155
    University of Ulsan College of Medicine, Asan Institute for Life Sciences, and Department of Pathology, Asan Medical Center, Seoul, Korea;, Email:
    Enhancer of zeste homolog 2 (EZH2) shows upregulated expression in tumors and is an important driver of tumor development and progression. However, the mechanism underlying the mediation of tumor aggressiveness by EZH2 remains unclear. We here investigated the levels of EZH2 in various normal and tumorous dog tissues and compared these patterns with those of the corresponding human tissues. Read More

    A case illustrating successful eradication of recurrent, aggressive basal cell carcinoma located in a scar with vismodegib.
    Dermatol Online J 2018 Feb 15;24(2). Epub 2018 Feb 15.
    Departments of Dermatology, Oregon Health & Sciences University, Portland, Oregon.
    Vismodegib is a small molecule inhibitor of the Hedgehog signaling pathway that has shown efficacy in the control of locally advanced or metastatic basal cell carcinoma, although proof of its effectiveness in the elimination of aggressive tumors is lacking. We report a case and provide complete histological evidence of a 69-year-old gentleman who presented with a recurrent, infiltrative, and sclerosing (morpheiform) basal cell carcinoma on his left upper lip that was entirely eradicated with a three-month course of vismodegib 150 mg daily. Complete histologic clearance of a tumor in a recurrent, infiltrative, and sclerosing basal cell carcinoma with vismodegib is uncommon. Read More

    Evaluation of p53 and Ki67 Expression Profiles in Basal Cell Carcinomas in a Usual and an Unusual Location.
    Turk Patoloji Derg 2018 Apr 9. Epub 2018 Apr 9.
    Department of Pathology, Ankara Yıldırım Beyazit University, Ankara Ataturk Research and Training Hospital, ANKARA, TURKEY.
    Objective: Owing to their importance in cell proliferation in cutaneous malignancies, we aimed to immunohistochemically compare the expression profiles of p53 and Ki67 in basal cell carcinoma (BCC) cases in both a usual and an unusual locations in this study.

    Material And Method: In this study we included 12 in an unusual location of BCC cases and 21 BCC cases in a usual location. Immunohistochemical expression of p53 and Ki67 antibodies were studied in 33 paraffin-embedded tissue specimens of basal cell carcinoma. Read More

    Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection.
    Appl Immunohistochem Mol Morphol 2018 Apr 7. Epub 2018 Apr 7.
    Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.
    Ber-EP4 has been the traditional immunostain used for the detection of basaloid skin tumors. Recently, MOC-31 has shown be superior to Ber-EP4 in the detection of basosquamous basal cell carcinoma (BCC) and many centers are now using both Ber-EP4 and MOC-31 antibodies together to detect these lesions. The objective of this study was to compare the utility of using both Ber-EP4 and MOC-31 immunostains in the detection of basaloid skin tumors and to better characterize the previously unknown staining properties of MOC-31 in cutaneous lesions. Read More

    Primary basosquamous carcinoma of the lower eyelid with ocular invasion A case report.
    Ann Ital Chir 2018 Mar 26;7. Epub 2018 Mar 26.
    Introduction: Ocular invasion is extremely rare for a primary eyelid Basosquamous Carcinoma (BSC). It can however occur in neglected cases if the clinical signs are overseen and the BSC is misdiagnosed for a less aggressive skin carcinoma.

    Materials And Methods: A 58-year-old man suffering from an inferior eyelid BSC that had been neglected for 7 years was referred to our clinic. Read More

    [Microcystic adnexal carcinoma: A case report].
    Ann Pathol 2018 Apr 2. Epub 2018 Apr 2.
    Service de dermatologie, CHU de Caen, avenue côte-de-nacre, 14033 Caen, France.
    We report a case of microcystic adnexal carcinoma in a 80-year-old woman. This is a rare malignant adnexal cutaneous tumor with glandular and follicular differentiation, rare, often asymptomatic, with late diagnosis and slow growth, locally aggressive and rarely metastatic. The distinction with other benign and malignant skin tumors is difficult. Read More

    Odontogenic Keratocysts as First Manifestation of Nevoid Basal Cell Carcinoma Syndrome: Surgical Management and Immunohistochemical Analysis.
    J Craniofac Surg 2018 Apr 4. Epub 2018 Apr 4.
    Dental School, State University of Western Paraná (UNIOESTE), Cascavel, Brazil.
    Nevoid Basal Cell Carcinoma Syndrome (NBCCS), also known as Gorlin syndrome, is a rare autosomal dominant disorder, with no gender predilection. Individuals with NBCCS are commonly diagnosed between 17 and 35 years old and can present multiple basal cell carcinomas scattered throughout the body, presence of recurrent and early-onset odontogenic keratocysts (OKCs) and skeletal abnormalities. This article describes a case of a 13-year-old white boy who referred complaining of facial asymmetry. Read More

    Do cancer registries play a role in determining the incidence of non-melanoma skin cancers?
    Eur J Dermatol 2018 Apr 5. Epub 2018 Apr 5.
    Oncology Unit/HUSE/SES, Tancredo Neves Avenue, Capucho. 49010-460, Aracaju, SE, Brazil, University Hospital/Federal University of Sergipe/EBSERH, Claudio Batista Street, Santo Antonio. 49060-108, Aracaju, SE, Brazil.
    Non-melanoma skin cancers have the highest incidence of all malignancies worldwide. However, cancer registries rarely include data on non-melanoma skin cancers because they tend to be under-reported. To determine incidence rates and changes over time for non-melanoma skin cancers in a mid-sized Brazilian population. Read More

    Alterations of the Human Skin - and -Glycome in Basal Cell Carcinoma and Squamous Cell Carcinoma.
    Front Oncol 2018 21;8:70. Epub 2018 Mar 21.
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.
    The glycome of one of the largest and most exposed human organs, the skin, as well as glycan changes associated with non-melanoma skin cancers have not been studied in detail to date. Skin cancers such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are among the most frequent types of cancers with rising incidence rates in the aging population. We investigated the healthy human skin - and -glycome and its changes associated with BCC and SCC. Read More

    Male secretory breast cancer: case in a 6-year-old boy with a peculiar gene duplication and review of the literature.
    Breast Cancer Res Treat 2018 Apr 3. Epub 2018 Apr 3.
    Breast Cancer Center, University Hospital, Pisa, Italy.
    Purpose: Secretory breast cancer (SBC) is one of the rarest breast cancer (BC), representing the majority of BC in childhood. Nevertheless, it elicits a lot of interest both for the peculiar morphology and the characteristic genetic features. Currently, there is no consensus on optimal treatment strategy. Read More

    Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer.
    J Dev Biol 2017 Nov 20;5(4). Epub 2017 Nov 20.
    Department of Molecular Oncology, Institute for Advanced Medical Sciences, Nippon Medical School, 1-396 Kosugi-machi, Nakahara-ku, Kawasaki 211-8533, Japan.
    The epidermis is the outermost layer of the skin and provides a protective barrier against environmental insults. It is a rapidly-renewing tissue undergoing constant regeneration, maintained by several types of stem cells. The Hedgehog (HH) signaling pathway is one of the fundamental signaling pathways that contributes to epidermal development, homeostasis, and repair, as well as to hair follicle development and follicle bulge stem cell maintenance. Read More

    Lateral orbital propeller flap technique for reconstruction of the lower eyelid defect.
    Ann R Coll Surg Engl 2018 Apr 1:e1-e3. Epub 2018 Apr 1.
    Department of Plastic Surgery, Hangzhou Plastic Surgery Hospital , Hangzhou , China.
    The lower eyelid, which has a unique anatomy and esthetic importance, is a common site of basal cell carcinoma. The reconstruction of the defect after the wide excision of the tumour is a special concern of many plastic surgeons. How to achieve the most satisfying effect through minimal invasive is important for patients. Read More

    Thoracoscopic right S6 sleeve segmentectomy for squamous-cell carcinoma arising from the B6 central bronchus.
    J Thorac Dis 2018 Feb;10(2):1077-1080
    Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan.
    We describe a patient with low respiratory function who underwent thoracoscopic sleeve segmentectomy to preserve lung function as much as possible. The patient had already used home oxygen therapy because of chronic obstructive lung disease. There was a squamous-cell carcinoma at inlet of right B6 bronchus, and cT1aN0M0 disease was diagnosed. Read More

    Basaloid Follicular Hamartoma: A Case Report and a Novel Cosmetic Treatment.
    J Clin Aesthet Dermatol 2018 Mar 1;11(3):39-41. Epub 2018 Mar 1.
    Dr. Segars is with NSU-COM/Largo Medical Center Dermatology Residency in Largo, Florida.
    Basaloid follicular hamartoma (BFH) is a rare, benign neoplasm of the hair follicle, characterized by multiple brown papules involving the face, scalp, and trunk. It is described by multiple clinical forms, and can present as localized or generalized. Diagnosis is made histologically via biopsy, which is important in order to distinguish BFH from basal cell carcinoma (BCC) or other malignant epithelial neoplasms. Read More

    Expression of protein arginine methyltransferase-5 in oral squamous cell carcinoma and its significance in epithelial-to-mesenchymal transition.
    Pathol Int 2018 Mar 30. Epub 2018 Mar 30.
    Department of Integrative Pathology, Jichi Medical University, Shimotsuke, Japan.
    Protein arginine methyltransferases (PRMT) 5, a member of type II arginine methyltransferases, catalyzes the symmetrical dimethylation of arginine residues on histone and non-histone substrates. Although the overexpression of PRMT5 has been reported in various cancers, its role in oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, we immunohistochemically examined the expression of PRMT5 in surgically resected oral epithelial dysplasia (OED, n = 8), oral intraepithelial neoplasia (OIN)/carcinoma in situ (CIS) (n = 11) and OSCC (n = 52) with or without contiguous OED lesions. Read More

    Trends in basal cell carcinoma incidence rates: a 16-year retrospective study of a population in central Poland.
    Postepy Dermatol Alergol 2018 Feb 19;35(1):47-52. Epub 2018 Feb 19.
    Department of Dermatology, Pediatric Dermatology and Dermatological Oncology, Medical University of Lodz, Lodz, Poland.
    Introduction: Basal cell carcinoma (BCC) is the most commonly occurring cancer worldwide, and the overall incidence is still rising. Unfortunately, the cancer registry in Poland does not record BCC individually. Thus, the incidence of BCC in a defined population is unknown. Read More

    Parotid Salivary Gland Basal Cell Adenocarcinoma in a Big-eared Opossum (Didelphis aurita).
    J Comp Pathol 2018 Feb 5;159:21-25. Epub 2018 Feb 5.
    Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Prof. Orlando Marques de Paiva 87, São Paulo, São Paulo, Brazil.
    The opossum (family Didelphidae) is a marsupial endemic to the Americas. Apart from the South American short-tailed opossum (Monodelphis domestica) and the Virginia opossum (Didelphis virginiana), there is considerable lack of knowledge about the health and diseases of most opossum species. Among these, the big-eared opossum (Didelphis aurita) is found in Argentina, Brazil and Paraguay. Read More

    Risk of skin cancer in HIV-infected patients: a Danish nationwide cohort study.
    J Am Acad Dermatol 2018 Mar 24. Epub 2018 Mar 24.
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark.
    Background: The risk of skin cancer in HIV-infected patients has not been extensively studied.

    Objective: To determine the risk of skin cancer in HIV-infected patients and compare it with the risk in the background population.

    Methods: In a matched, nationwide population-based cohort study we compared the risk of skin cancer in 4280 HIV-infected patients from the Danish HIV cohort study with a background population cohort, according to the level of immunosuppression and route of transmission. Read More

    Spontaneous adrenocorticotropic hormone (ACTH) normalisation due to tumour regression induced by metyrapone in a patient with ectopic ACTH syndrome: case report and literature review.
    BMC Endocr Disord 2018 Mar 27;18(1):19. Epub 2018 Mar 27.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Aichi Medical University, School of Medicine, Nagakute, Japan.
    Background: Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case of EAS in which ACTH production by a lung tumour was reduced by metyrapone (MTP) and also reviewed previous cases of ectopic ACTH production suppressed via steroidogenesis inhibition. Read More

    Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal squamous cell carcinoma.
    Gen Thorac Cardiovasc Surg 2018 Mar 26. Epub 2018 Mar 26.
    Department of Gastroenterology, The Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
    Objective: Our previous differential transcriptome analysis between a paired specimen of normal and esophageal squamous cell carcinoma (ESCC) tissues found aberrant expression of kallikrein-related peptidase 13 (KLK13) in tumors. In this study, we evaluated the expression of KLK13 in many ESCC cases in relation with clinical features, and the prognosis.

    Methods: Eighty-eight ESCC cases were subjected to immunohistological staining for KLK13 and classified into KLK13-negative and KLK13-positive groups. Read More

    Differentiated cervical intraepithelial neoplasia-associated invasive cervical squamous cell carcinoma as a source of major cytopathological and surgical pathological discrepancy in Papanicolaou smear screening tests.
    Cytopathology 2018 Apr;29(2):143-149
    Department of Pathology and Laboratory Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
    Introduction: Differentiated cervical intraepithelial neoplasia (dCIN) analogous to differentiated squamous intraepithelial neoplasia of the vulva is characterised by the proliferation of atypical cells limited to the basal/parabasal layers. Exfoliative cytology of dCIN has not been investigated.

    Methods And Results: A 46-year-old woman, with a history of normal Papanicolaou (Pap) smear up to 2 years prior to the occurrence of postcoital vaginal bleeding had two consecutive Pap smears, which only revealed atypical squamous cells of unknown significance (ASCUS). Read More

    The evolution of bladder cancer genomics: What have we learned and how can we use it?
    Urol Oncol 2018 Mar 21. Epub 2018 Mar 21.
    Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:
    Background: With advancements in molecular biology techniques, great progress has been made in the understanding of urothelial carcinoma pathogenesis.

    Objective: To examine the historic description of molecular alterations in bladder cancer and their evolution towards our current comprehension of the biology of the disease.

    Results: Historically, a two-pathway model was described from histological and cytogenetic studies: low-grade papillary non-muscle invasive bladder cancers (NMIBC) were described to arise from epithelial hyperplasia with loss of chromosome 9 as an early event, whereas muscle-invasive bladder cancers (MIBC) were considered to develop from dysplasia, associated with genetic instability. Read More

    Perineural Spread of Nonmelanoma Skin Cancer to the Brachial Plexus: Identifying Anatomic Pathway(s).
    World Neurosurg 2018 Mar 20. Epub 2018 Mar 20.
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:
    Background: Perineural spread leading to brachial plexopathy has recently been described in cases of melanoma. The occurrence and mechanism for nonmelanoma skin cancer spread to the brachial plexus is poorly understood.

    Methods: A retrospective chart review of the Mayo Clinic database was conducted to identify patients with nonmelanoma skin cancer and brachial plexopathy between 2000 and 2017. Read More

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