28,390 results match your criteria Basal Cell Carcinoma


Biopsy Outperforms Reflectance Confocal Microscopy in Diagnosing and Subtyping Basal Cell Carcinoma: Results and Experiences from a Randomized Controlled Multicentre Trial.

Br J Dermatol 2020 Jul 6. Epub 2020 Jul 6.

Department of Dermatology, Radboud University Medical Centre, Nijmegen, The Netherlands.

Background: Reflectance confocal microscopy (RCM) is a non-invasive method for skin assessment, allowing entire lesion evaluation up to the papillary dermis. Therefore, RCM is a potentially attractive alternative to punch biopsy in basal cell carcinoma (BCC).

Objectives And Design: This randomized controlled trial aimed to investigate RCM as alternative to punch biopsy in a real-world clinical setting. Read More

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http://dx.doi.org/10.1111/bjd.19381DOI Listing

Boosting the Synthesis of Pharmaceutically Active Abietane Diterpenes in Hairy Roots by Engineering the and Genes.

Front Plant Sci 2020 18;11:924. Epub 2020 Jun 18.

Department of Pharmacy, University of Salerno, Fisciano, Italy.

Abietane diterpenoids (ADs), synthesized in the roots of different species, such as aethiopinone, 1-oxoaethiopinone, salvipisone, and ferruginol, have a variety of known biological activities. We have shown that aethiopinone has promising cytotoxic activity against several human tumor cell lines, including the breast adenocarcinoma MCF7, HeLa, epithelial carcinoma, prostate adenocarcinoma PC3, and human melanoma A375. The low content of these compounds in natural sources, and the limited possibility to synthesize them chemically at low cost, prompted us to optimize the production of abietane diterpenoids by targeting genes of the methylerythritol phosphate (MEP) pathway, from which they are derived. Read More

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http://dx.doi.org/10.3389/fpls.2020.00924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315395PMC

Amelanotic melanoma in a patient with oculocutaneous albinism.

Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.

Department of Dermatology, Hospital Clinico Universitario de Valladolid, Valladolid.

Oculocutaneous albinism is a genetically heterogeneous, autosomal recessive group of disorders characterized by a generalized decreased or absence of melanin pigment in the eyes, hair, and skin. These patients have a greater sensitivity to UV radiation and a predisposition to skin tumors, mainly squamous cell carcinoma and basal cell carcinomas, and to a lesser extent malignant melanomas. Melanoma can be one of the most challenging cancers to diagnose in patients with albinism. Read More

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Basal cell carcinoma associated with erythema ab igne.

Dermatol Online J 2020 Apr 15;26(4). Epub 2020 Apr 15.

Department of Dermatology, Razi Hospital, Tehran University of Medical Science, Tehran.

Erythema ab igne is a skin condition mainly caused by heat exposure. Erythema ab igne usually follows a favorable prognosis. However, it may increase the risk of developing cutaneous malignancy in the involved skin. Read More

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Unusual presentation of Kaposi sarcoma in an HIV-negative woman.

Dermatol Online J 2020 Apr 15;26(4). Epub 2020 Apr 15.

The University of Texas MD Anderson Cancer Center, Houston, TX.

Kaposi sarcoma typically presents as violaceous macules and papules in immunocompromised, specifically HIV-positive, patients. Its distinct clinical features often facilitate rapid diagnosis. In this article, we report a case of Kaposi sarcoma presenting as a concerning yet nondescript lesion in an HIV-negative woman. Read More

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Maxillofacial rehabilitation of nasal defect with nasal prosthesis using donor method: A case report.

Niger J Clin Pract 2020 Jul;23(7):1022-1025

Department of Dental Diagnostic Science and Oral Biology, King Khalid University, Abha, Saudi Arabia.

Maxillofacial prosthetics is the branch of prosthodontics which involves rehabilitation of the defects in the maxillofacial region involving the hard and soft tissue with the prosthesis. Facial defects that occur in the midfacial regions are commonly due to trauma and neoplasms like basal cell carcinoma which involves the nose. Reconstruction of the nose is an important esthetic challenge due to its esthetic and retention problems. Read More

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http://dx.doi.org/10.4103/njcp.njcp_657_19DOI Listing

Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas.

Anticancer Res 2020 Jul;40(7):4017-4022

Department of Translational Medical Sciences, University of Campania "L. Vanvitelli", Naples, Italy

Background/aim: Squamous cell carcinoma (SCC) is highly prevalent in kidney transplant patients (KT). It is characterized by the presence of an inflammatory infiltrate. In this study, we examined the presence of similar infiltrates in intact skin, which could be regarded as a precancerous step. Read More

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http://dx.doi.org/10.21873/anticanres.14396DOI Listing

Basal Cell Carcinoma and Eccrine Porocarcinoma of the Eyelid.

Ophthalmic Plast Reconstr Surg 2020 Jun 17. Epub 2020 Jun 17.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

An 81-year-old woman presented with a progressively enlarging indurated, firm lesion encompassing one-third of the left upper eyelid. Four years prior, a similar lesion at that same site had been excised and diagnosed as a basal cell carcinoma. The patient underwent a full-thickness excision of the lesion with frozen section, cryotherapy, and reconstruction. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001743DOI Listing

Trends in pediatric skin cancer.

Curr Opin Pediatr 2020 Jun 30. Epub 2020 Jun 30.

Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: To inform pediatric providers of the clinical characteristics, underlying genetic drivers, and therapeutic options for skin cancer arising in childhood and adolescence.

Recent Findings: The incidence of melanoma in pediatric patients has been declining in the past decades. Pediatric-specific diagnostic criteria should be utilized when assessing lesions concerning for melanoma to better account for the different presentations seen in pediatric disease compared with adults, such as an increased prevalence of amelanotic melanoma or frequent mimic of benign pediatric lesions. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000917DOI Listing

Metastatic Basal Cell Carcinoma of the Skin: A Comprehensive Literature Review, Including Advances in Molecular Therapeutics.

Adv Anat Pathol 2020 Jul 1. Epub 2020 Jul 1.

Department of Pathology, The Barzilai Medical Center, Ashkelon, Israel.

Basal cell carcinoma (BCC) of the skin is the most common type of malignant human tumor. In Europe, the incidence of BCC ranges from 44.6 to 128 cases per 100,000 inhabitants annually, whereas in the United States, the yearly incidence rate ranges between 500 and 1500. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000267DOI Listing

Eyelid skin trichilemmoma and underlying local malignancy: is an aggressive treatment necessary?

BMJ Open Ophthalmol 2020 25;5(1):e000513. Epub 2020 Jun 25.

Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.

Objective: Trichilemmoma is a benign tumour derived from the outer root sheath of hair follicles. Trichilemmoma can be associated with basal cell carcinoma (BCC), either as a collision lesion or from malignant transformation. This study evaluates malignancy associated with eyelid trichilemmoma and principles of treatment. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319780PMC

REPLY to MS#JAAD-D-20-02240: Effective Therapy for Advanced Basal Cell Carcinoma.

J Am Acad Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Department of Medicine, Division of Hematology/Oncology, University of California San Diego, La Jolla, CA; Center of Personalized Cancer Therapy, University of California San Diego, La Jolla, CA.

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http://dx.doi.org/10.1016/j.jaad.2020.06.988DOI Listing

Polygenic risk scores allow risk stratification for keratinocyte cancer in organ transplant recipients.

J Invest Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Statistical Genetics Lab, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Australia; School of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove QLD 4059, Australia.

Organ transplant recipients (OTRs) have an elevated risk for keratinocyte cancers (KC); basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). We assessed whether polygenic risk scores (PRSs) generated in non-transplantees from the UK Biobank and 23andMe (13,981 SCC, 33,736 BCC, and >560,000 controls), can predict KC risk in an independent OTR cohort. After adjusting for traditional risk factors, compared to the bottom 20%, OTRs in the top 20% PRS had an increased risk of BCC (OR = 3. Read More

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http://dx.doi.org/10.1016/j.jid.2020.06.017DOI Listing

Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity.

Mol Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Biosciences, Cancer Cluster Salzburg, Paris-Lodron University Salzburg, Salzburg, Austria.

Genetic activation of Hedgehog (HH)/GLI signaling causes basal cell carcinoma (BCC), a very frequent non-melanoma skin cancer. Small molecule targeting of the essential HH effector Smoothened (SMO) has proven an effective therapy of BCC, though the frequent development of drug resistance poses major challenges to anti-HH treatments. In light of recent breakthroughs in cancer immunotherapy, we analyzed the possible immunosuppressive mechanisms in HH/GLI-induced BCC in detail. Read More

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http://dx.doi.org/10.1002/1878-0261.12758DOI Listing

Periorbital, conjunctival and primary intraorbital carcinomas: Survival and risk factors after orbital exenteration.

Eye (Lond) 2020 Jul 1. Epub 2020 Jul 1.

Department of Oral and Maxillofacial Surgery, University of Duisburg-Essen, Kliniken-Essen-Mitte, Henricistr. 92, 45136, Essen, Germany.

Objectives: This study aimed to analyse the disease-free survival (DFS), overall survival (OS) and risk factors after orbital exenteration in patients with periorbital, conjunctival and primary intraorbital carcinomas.

Methods: Patients undergoing orbital exenteration due to a primary carcinoma between March 2000 and March 2018 were included in this retrospective study. Risk factors in all the patients were evaluated using univariate and multivariate analyses. Read More

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http://dx.doi.org/10.1038/s41433-020-1055-1DOI Listing

Ectopic Cushing syndrome in Colombia.

Arch Endocrinol Metab 2020 Jun 29. Epub 2020 Jun 29.

Departamento de Neoplasia Endocrina y Trastornos Hormonales, Universidad de Texas, MD Anderson Cancer Center, Houston Texas.

Objective: The aim was to describe the clinical features of patients with ectopic Cushing syndrome (ECS) from Colombia and compare these findings with other series to provide the best management for these patients.

Materials And Methods: Records of patients with ECS from 1986 to 2017 were retrospectively reviewed; patients with a diagnosis of adrenal or pituitary Cushing syndrome (CS) were excluded.

Results: Fourteen patients with ECS were analyzed in this study. Read More

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http://dx.doi.org/10.20945/2359-3997000000271DOI Listing

Classification of Skin Lesions into Seven Classes Using Transfer Learning with AlexNet.

J Digit Imaging 2020 Jun 30. Epub 2020 Jun 30.

Department of Electronics and Communication, Faculty of Engineering, Zagazig University, Zagazig 44519, Egypt.

Melanoma is deadly skin cancer. There is a high similarity between different kinds of skin lesions, which lead to incorrect classification. Accurate classification of a skin lesion in its early stages saves human life. Read More

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http://dx.doi.org/10.1007/s10278-020-00371-9DOI Listing

Reply Letter to the Editor Regarding: Basal cell carcinoma: Management of advanced or metastatic cancer with checkpoint inhibitors and concurrent paradoxical development of new superficial tumors.

J Am Acad Dermatol 2020 Jun 27. Epub 2020 Jun 27.

Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.1016/j.jaad.2020.06.987DOI Listing

Melanoma and non-melanoma skin cancer among patients who attended at King Khalid University Hospital in Riyadh, Saudi Arabia from 2007 - 2018.

Saudi Med J 2020 Jul;41(7):709-714

Division of Plastic Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess the prevalence of melanoma and non-melanoma skin cancer for patients attended King Khalid University Hospital, Riyadh, Saudi Arabia. We are also assessing the most common category of skin cancer to be encountered among those patients. Methods: The authors conducted a retrospective study including all patients (Saudi and non-Saudi) who attended King Khalid University Hospital (KKUH) at the period of (2007-2018). Read More

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http://dx.doi.org/10.15537/smj.2020.7.25138DOI Listing

Periocular skin cancer: Diagnosis and management.

Dis Mon 2020 Jun 26:101046. Epub 2020 Jun 26.

Division of Ophthalmology, NorthShore University Health System, 2050 Pfingsten Rd., Ste. 280, Glenview, IL 60026, United States; Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, United States. Electronic address:

The periocular region sees high rates of cancer compared to the rest of the body and can be affected by several unique tumors. Treatment typically involves surgical excision, although adjunctive therapies and prognosis vary depending on the diagnosis. Basal cell carcinoma (BCC) is the most common malignancy affecting this region and should be excised promptly. Read More

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http://dx.doi.org/10.1016/j.disamonth.2020.101046DOI Listing

Trichoblastomas Mimicking Basal Cell Carcinoma: The Importance of Identification and Differentiation.

Cureus 2020 May 25;12(5):e8272. Epub 2020 May 25.

Dermatology, State University of New York Downstate Medical Center, Brooklyn, USA.

Trichoblastoma is a rare, slow-growing, benign cutaneous tumor derived from follicular germinative cells. Trichoblastoma commonly appears as an asymptomatic, symmetrical, well-circumscribed, skin-colored to brown or blue-black papule or nodule. It may appear clinically and histologically similar to basal cell carcinoma, making its diagnosis challenging. Read More

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http://dx.doi.org/10.7759/cureus.8272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314372PMC

Therapeutic Implications of Immunohistochemical Expression Pattern of the Cancer Stem Cell Marker (Nestin) in Basal and Squamous Cell Carcinomas.

Dermatol Ther 2020 Jun 28:e13921. Epub 2020 Jun 28.

Department of Dermatology, National Research Centre.

Cancer stem cells (CSC) are populations of cells responsible for tumor initiation, progression and therapeutic resistance in many cancers. In the present study, we aimed to investigate the expression pattern and clinical significance of the stem cell marker nestin, in Squaous cell carcinoma (SCC) and basal cell carcinoma (BCC). The samples (23 cases of BCC and 22 cases of SCC) were immunohistochemically examined for the expression of nestin and its correlation with the corresponding clinical and pathological parameters. Read More

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http://dx.doi.org/10.1111/dth.13921DOI Listing

Dermatoses of the world: Burden of skin disease and associated socioeconomic status in the world.

J Am Acad Dermatol 2020 Jun 25. Epub 2020 Jun 25.

Apex Dermatology and Skin Surgery Center, Mayfield Heights, OH; Lake Erie College of Osteopathic Medicine, Erie, PA.

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http://dx.doi.org/10.1016/j.jaad.2020.05.157DOI Listing

Association between circulating FSTL-1 and metabolic syndrome in middle-aged and old population: a cross-sectional study.

Diabetes Metab Res Rev 2020 Jun 27:e3373. Epub 2020 Jun 27.

Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Aim: Follistatin-like-1 (FSTL-1) is considered to be a novel cytokine, and it is associated with metabolic diseases. However, it is necessary to investigate further the association of FSTL-1 with metabolic syndrome (MetS) and insulin resistance (IR). We performed a cross-sectional study to investigate the associated of circulating FSTL-1 with the MetS. Read More

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http://dx.doi.org/10.1002/dmrr.3373DOI Listing

A Deep Learning Algorithm to Detect the Presence of Basal Cell Carcinoma on Mohs Micrographic Surgery Frozen Sections.

J Am Acad Dermatol 2020 Jun 23. Epub 2020 Jun 23.

University of California San Diego, Department of Dermatology.

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http://dx.doi.org/10.1016/j.jaad.2020.06.080DOI Listing

Absence of BRAFV600E Immunohistochemical Expression in Sporadic Odontogenic Keratocyst, Syndromic Odontogenic Keratocyst and Orthokeratinized Odontogenic Cyst.

J Oral Pathol Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Mumbai, 400008, India.

Background: Odontogenic keratocyst (OKC) is a unique developmental odontogenic cyst that has the potential to behave aggressively, and is associated with the nevoid basal cell carcinoma syndrome. Orthokeratinized odontogenic cyst (OOC) is a distinct, uncommon odontogenic cyst. It significantly differs from OKC not only in its epithelial lining but also in proliferating kinetics, clinical, immunohistochemical and biological behaviour. Read More

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http://dx.doi.org/10.1111/jop.13081DOI Listing

The 2019 Genitourinary Pathology Society (GUPS) White Paper on Contemporary Grading of Prostate Cancer.

Arch Pathol Lab Med 2020 Jun 26. Epub 2020 Jun 26.

From the Departments of Pathology (Drs Epstein, DeMarzo, and Lotan), Urology (Dr Epstein), and Oncology (Dr Epstein), The Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Pathology and Laboratory Medicine and Urology, University of Tennessee Health Science, Memphis (Dr Amin); Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Dr Fine); Department of Pathology, Fundacio Puigvert, Barcelona, Spain (Dr Algaba); Department of Pathology, University of Southern California, Los Angeles (Dr Aron); Department of Pathology, Faculty of Medicine, Koç University, İstanbul, Turkey (Dr Baydar); Department of Pathology, Champalimaud Centre for the Unknown, Lisbon, Portugal (Dr Beltran); Department of Pathology, McGill University Health Center, Montréal, QC, Canada (Dr Brimo); Department of Pathology, Mayo Clinic, Rochester, Minnesota (Drs Cheville and Jimenez); Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (Dr Colecchia); Department of Pathology, Hôpital Tenon, Sorbonne University, Paris, France (Dr Comperat); Pathology Department, Rede D'OR-Sao Luiz, Sao Paulo, SP, Brazil (Dr da Cunha); Douglass Hanly Moir Pathology, Sydney, Australia (Dr Delprado); Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee (Drs Giannico and Gordetsky); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Guo); Department of Pathology, Oregon Health and Science University, Portland (Dr Hansel); Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Dr Hirsch); Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California (Dr Huang); Department of Pathology, Yale School of Medicine, New Haven, Connecticut (Dr Humphrey); Department of Pathology and Laboratory Medicine and Urology, Weill Cornell Medicine, New York, New York (Drs Khani and Robinson); Department of Pathology, Qingdao Municipal Hospital, Qingdao, Shandong, China (Dr Kong); Departments of Pathology and Laboratory Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida (Dr Kryvenko); Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan (Drs Kunju and Mehra); Perelman School of Medicine, University of Pennsylvania, Philadelphia (Dr Lal); Department of Pathology, CHUM, Université de Montréal, Montréal, QC, Canada (Dr Latour); Douglass Hanly Moir Pathology, Faculty of Medicine and Health Sciences Macquarie University, North Ryde, Australia (Dr Maclean); Department of Pathology, The University of Alabama at Birmingham, Birmingham (Drs Magi-Galluzzi and Netto); Department of Surgical Pathology, Tata Memorial Hospital, Parel, Mumbai, India (Dr Menon); Departments of Pathology and Laboratory Medicine and Urology, University of Rochester Medical Center, Rochester, New York (Dr Miyamoto); Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region, United Hospitals, Ancona, Italy (Dr Montironi); Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio (Dr Nguyen); Department of Pathology, Emory University School of Medicine, Atlanta, Georgia (Dr Osunkoya); Department of Pathology, Ohio State University, Columbus (Drs Parwani and Zynger); Department for BioMedical Research, University of Bern, Bern, Switzerland (Dr Rubin); Department of Pathology, The University of Texas Southwestern Medical Center, Dallas (Dr Shah); Institute of Pathology, St Luke's Medical Center, Quezon City and Global City, Philippines (Dr So); Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan (Dr Takahashi); Argos Laboratory, Federal University of Ceara, Fortaleza, Brazil (Dr Tavora); Department of Pathology, University of Washington School of Medicine, Seattle (Drs Tretiakova and True); Departments of Pathology and Laboratory Medicine and Urology, University of North Carolina, Chapel Hill (Dr Wobker); Department of Pathology, Northwestern University, Chicago, Illinois (Dr Yang); Department of Pathology, Tufts Medical Center, Boston, Massachusetts (Dr Zhou); and Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada (Dr Trpkov). Dr Kong is currently located at Kaiser Permanente Sacramento Medical Center, Sacramento, California.

Context.—: Controversies and uncertainty persist in prostate cancer grading.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2020-0015-RADOI Listing
June 2020
2.838 Impact Factor

Eyelid basal cell carcinoma with neuroendocrine differentiation: a case report and literature review.

Orbit 2020 Jun 25:1-4. Epub 2020 Jun 25.

Department of Ophthalmology, Western Health , Melbourne, Australia.

Basal cell carcinoma (BCC) is the most common type of malignant tumor in the periocular region. BCCs with neuroendocrine differentiation in the periocular region, however, have not been described in the literature. We present a retrospective case review of a patient with an eyelid BCC with neuroendocrine differentiation. Read More

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http://dx.doi.org/10.1080/01676830.2020.1778738DOI Listing

Activating transcription factor 3 inhibits endometrial carcinoma aggressiveness via JunB suppression.

Int J Oncol 2020 Jun 19. Epub 2020 Jun 19.

School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P.R. China.

The function of activating transcription factor 3 (ATF3) in cancer is context‑dependent and its role in endometrial carcinoma (EC) is yet to be elucidated. In the present study, ATF3 was indicated to be downregulated, while one of the ATF3‑interacting proteins, JunB, was upregulated in ECs according to western blot analysis. After overexpression in ECs, ATF3 inhibited the proliferation and invasion of EC cells and enhanced apoptosis, as well as suppressed the expression of JunB. Read More

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http://dx.doi.org/10.3892/ijo.2020.5084DOI Listing

Automatic Segmentation of Epidermis and Hair Follicles in Optical Coherence Tomography Images of Normal Skin by Convolutional Neural Networks.

Front Med (Lausanne) 2020 4;7:220. Epub 2020 Jun 4.

Instituto de Investigación e Innovación en Bioingeniería, I3B, Universitat Politècnica de València, Valencia, Spain.

Optical coherence tomography (OCT) is a well-established bedside imaging modality that allows analysis of skin structures in a non-invasive way. Automated OCT analysis of skin layers is of great relevance to study dermatological diseases. In this paper, an approach to detect the epidermal layer along with the follicular structures in healthy human OCT images is presented. Read More

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http://dx.doi.org/10.3389/fmed.2020.00220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287173PMC

Portraits of Suzanne, an Osage Woman's Story of Loving the Sun and Living With Skin Cancer.

AMA J Ethics 2020 Jun 1;22(6):E557-564. Epub 2020 Jun 1.

Assistant professor of health promotion in the College of Public Health at the University of Nebraska Medical Center in Omaha.

Suzanne, an elder of The Osage Nation, has been diagnosed with basal cell carcinoma, squamous cell carcinoma, and melanoma skin cancer. Her daughter, Bobbie, a cancer researcher working for the Youth Enjoy Science Research Education Program, conducted a case study to share Suzanne's story through written narrative and a series of images that present Suzanne's reflections on cancer prevention and treatment from a holistic perspective. Seven interview transcripts, as well as photographs, drawings, and paintings of Suzanne, were created and analyzed to explore Suzanne's lived experience of cancer. Read More

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http://dx.doi.org/10.1001/amajethics.2020.557DOI Listing

USP28 and USP25 are down-regulated by Vismodegib in vitro and in colorectal cancer cell lines.

FEBS J 2020 Jun 23. Epub 2020 Jun 23.

Department of Analytical Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China.

Deubiquitinase USP28 plays a crucial role in tumorigenesis by enhancing the stabilities of multiple cancer-related proteins including c-Myc, Notch1, LSD1 etc., and has become an attractive target for anti-cancer drug development. However, to date, only a few of USP28-targeted active compounds have been developed, and the active compound-binding pocket in USP28 has not been experimentally revealed yet. Read More

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http://dx.doi.org/10.1111/febs.15461DOI Listing

Growth rate of clinically diagnosed superficial basal cell carcinoma and changes in dermoscopic features over time.

Australas J Dermatol 2020 Jun 23. Epub 2020 Jun 23.

Department of Dermatology, Waikato Hospital, Waikato District Health Board, Hamilton, New Zealand.

Background/objectives: Basal cell carcinoma (BCC) is the most commonly occurring skin cancer. BCCs have been found to generally grow slowly. Data are limited on how the dermoscopic characteristics of BCCs evolve. Read More

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http://dx.doi.org/10.1111/ajd.13352DOI Listing

Contrasting DCIS and invasive breast cancer by subtype suggests basal-like DCIS as distinct lesions.

NPJ Breast Cancer 2020 17;6:26. Epub 2020 Jun 17.

Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

Ductal carcinoma in situ (DCIS) is a non-invasive type of breast cancer with highly variable potential of becoming invasive and affecting mortality. Currently, many patients with DCIS are overtreated due to the lack of specific biomarkers that distinguish low risk lesions from those with a higher risk of progression. In this study, we analyzed 57 pure DCIS and 313 invasive breast cancers (IBC) from different patients. Read More

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http://dx.doi.org/10.1038/s41523-020-0167-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299965PMC

Reconstructing Ear Defects Using the Revolving Door Island Flap: A Case Series.

Actas Dermosifiliogr 2020 Jun 21. Epub 2020 Jun 21.

Servicio de Dermatología, Hospital General Universitario de Ciudad Real, Ciudad Real, España.

Background And Objectives: Defects of the anterior region of the pinna pose a reconstruction challenge owing to the complex topography and difficult access. We report our experience using the revolving door island flap (RDIF) to reconstruct pinna defects and present the surgical results.

Material And Methods: Retrospective descriptive study of patients undergoing ear reconstruction using RDIF at different sites of the anterior region after resection of malignant tumors. Read More

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http://dx.doi.org/10.1016/j.ad.2020.03.002DOI Listing

Photodynamic Diagnosis and Photodynamic Therapy in Basal Cell Carcinoma Using Novel Laser Light Source.

Photodiagnosis Photodyn Ther 2020 Jun 20:101883. Epub 2020 Jun 20.

Department of Pathology, Wroclaw Medical University, Poland. Electronic address:

The aim of the present study was evaluating the effects and safety of new laser light source in PDD and PDT of basal cell carcinoma, BCC. The patients presented challenging localizations of the tumor or tumor combined with Gorlin syndrome. The PDD and PDT was performed in 50 patients with 54 histologically confirmed BCCs. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101883DOI Listing

A Challenge for Hemophilia Treatment: Hemophilia and Cancer.

J Pediatr Hematol Oncol 2020 Jun 19. Epub 2020 Jun 19.

Department of Pediatric Hematology and Oncology, Istanbul University, Oncology Institute, Istanbul, Turkey.

Background: The risk of developing cancer increases with age and also adverse environmental conditions. The same holds true in the aging people with hemophilia (PwH). Furthermore, cancer is an important challenge for physicians working in multidisciplinary hemophilia care centers. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001868DOI Listing

Tumour-infiltrating Langerhans cells in non-melanoma skin cancer, a clinical and immunohistochemical study.

Ecancermedicalscience 2020 15;14:1045. Epub 2020 May 15.

Department of Pathology, Faculty of Medicine, Menoufia University, Shebein Elkom, 32511, Egypt.

Non-melanoma skin cancer, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) represents 78.5% of all skin malignant tumours in Egypt. Dendritic cells can be found in almost all human tumours, they play an important role in antitumour immunity. Read More

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http://dx.doi.org/10.3332/ecancer.2020.1045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289606PMC

Decreased Messenger RNA Expression in Basal Cell Carcinoma.

Indian J Dermatol 2020 May-Jun;65(3):178-182

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: , , and have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma. However, their expression level in basal cell carcinoma (BCC) has not been elucidated. We hypothesized BCC, contrary to SCC, and melanoma, could be a suitable model to study mechanisms which attenuate tumor metastasis. Read More

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http://dx.doi.org/10.4103/ijd.IJD_387_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292465PMC

Reflectance confocal microscopy. Part II. Diagnostic criteria of common benign and malignant neoplasms, dermoscopic and histopathological correlates of key confocal criteria, and diagnostic algorithms.

J Am Acad Dermatol 2020 Jun 18. Epub 2020 Jun 18.

The Kittner Skin Cancer Screening and Research Institute, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Dermatology Service, Memorial Sloan-Kettering Center, New York, NY.

Reflectance confocal microscopy (RCM) is a high-resolution, non-invasive tool currently FDA-approved for obtaining and interpreting images of the skin and cutaneous neoplasms with the goal of decreasing biopsy of benign lesions. Part II of this continuing medical education series focuses on identifying key criteria for the diagnosis of common skin cancers-melanoma, basal cell carcinoma, and squamous cell carcinoma. We contrast these findings with RCM features of common benign lesions-melanocytic nevi, solar lentigo, seborrheic keratosis, lichen planus-like keratosis, and sebaceous hyperplasia. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.154DOI Listing

Genomic profiling of late-onset basal cell carcinomas from two brothers with Naevoid Basal Cell Carcinoma Syndrome.

J Eur Acad Dermatol Venereol 2020 Jun 21. Epub 2020 Jun 21.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Background: Naevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant genetic disorder. It is commonly caused by mutations in PTCH1 and chiefly characterized by multiple basal cell carcinomas (BCCs) developing prior to the age of 30 years. In rare cases NBCCS presents with a late onset of BCC development. Read More

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http://dx.doi.org/10.1111/jdv.16767DOI Listing

Cutaneous Adnexal Carcinosarcoma: Immunohistochemical and Molecular Evidence of Epithelial Mesenchymal Transition.

J Cutan Pathol 2020 Jun 21. Epub 2020 Jun 21.

Department of Pathology, Dermatopathology Section, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Cutaneous carcinosarcomas are rare biphenotypic tumors that simultaneously show epithelial and mesenchymal differentiation. The most common carcinomatous components in skin carcinosarcomas are basal cell carcinoma and squamous cell carcinoma; adnexal carcinomas are rarely encountered. We report a case of an adnexal carcinoma with ductal and squamous differentiation and spindle cell component, interpreted as carcinosarcoma. Read More

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http://dx.doi.org/10.1111/cup.13782DOI Listing
June 2020
1.560 Impact Factor

Intracapsular carcinoma ex basal cell adenoma of the parotid gland.

Int J Oral Maxillofac Surg 2020 Jun 17. Epub 2020 Jun 17.

Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, Changchun, China. Electronic address:

Malignant transformation of basal cell adenoma is extremely rare. We report the case of a 63-year-old Chinese woman, who had noticed a slowing growing mass in her right parotid gland with slight pain for 1 month. Based on physical and ultrasound examinations, a diagnosis of benign salivary gland tumour was made before the surgery. Read More

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http://dx.doi.org/10.1016/j.ijom.2020.05.012DOI Listing

Co-inheritance of Naevoid Basal Cell Carcinoma Syndrome and Neurofibromatosis Type 1 associated with an exceptional spectrum of tumours.

Br J Dermatol 2020 Jun 20. Epub 2020 Jun 20.

Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.

The tumours arising in naevoid basal cell carcinoma syndrome (NBCCS) and neurofibromatosis type 1 (NF1) are distinct, and are exemplars of the specific consequences of mutations arising in different tumour suppressor genes. Whilst each syndrome has recognised pathognomonic tumours, an exceptional spectrum of tumours presenting in an individual with either syndrome may represent the interaction of an additional tumour suppressor gene. Read More

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http://dx.doi.org/10.1111/bjd.19324DOI Listing

The Effectiveness of Photodynamic Therapy and Cryotherapy on Patients with Basal cell carcinoma: A Systematic Review and Meta-analysis.

Dermatol Ther 2020 Jun 19:e13881. Epub 2020 Jun 19.

Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.

Background: Basal cell carcinoma (BCC) is known as the most common type of non-melanoma skin cancer (NMSC) worldwide. The aim of this study is to show the effectiveness of photodynamic therapy and cryotherapy on patients with BCCs with the use of meta-analyses in order to see if there is a possible superiority of one treatment over the other.

Methods: We searched the databases Pubmed, MEDLINE, CINAHL, Scopus, OVID, Embase, Science Direct, JAMA Dermatology and Research Gate in April 2020. Read More

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http://dx.doi.org/10.1111/dth.13881DOI Listing

High-frequency (20 MHz) high-intensity focused ultrasound: New Treatment of actinic keratosis, basal cell carcinoma, and Kaposi sarcoma. An open-label exploratory study.

Skin Res Technol 2020 Jun 17. Epub 2020 Jun 17.

TOOsonix A/S, Horsholm, Denmark.

Background: Skin cancer is common, growing, challenging, and in need of progress in early-stage treatment. 20 MHz high-intensity focused ultrasound (HIFU) is new and applied to actinic keratosis (AK) and skin cancers for the first time. HIFU of lower frequency is already used in the treatment of internal cancers. Read More

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http://dx.doi.org/10.1111/srt.12883DOI Listing

A comparative study of long interspersed element-1 protein immunoreactivity in cutaneous malignancies.

BMC Cancer 2020 Jun 17;20(1):567. Epub 2020 Jun 17.

Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background: Skin cancer is the most common cancer worldwide and commonly classified into malignant melanoma (MM) and Nonmelanoma skin cancers (NMSCs), which mainly include basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The extent to which Long Interspersed Element-1 (LINE-1, L1) ORF1p is expressed in cutaneous malignancies remains to be evaluated. This study aimed to assess LINE-1 ORF1p immunoreactivity in various skin cancer subtypes. Read More

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http://dx.doi.org/10.1186/s12885-020-07050-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301980PMC

Basal Cell Carcinoma in the Nasal Vestibule.

J Drugs Dermatol 2020 Mar;19(3):333-334

Basal Cell Carcinoma (BCC) is one of the most common human malignant neoplasms and is the most prevalent skin cancer in the United States with over four million new cases reported annually.1,2 Most BCCs arise in the skin from exposure to the sun’s ultraviolet radiation. However, it is possible for BCCs to present in sun-protected areas due to factors other than sun exposure. Read More

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Enhanced immortalization, mutations and other biological drivers of breast invasive carcinoma in Black/African American patients.

Gene X 2020 Dec 1;5:100030. Epub 2020 May 1.

Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 19 Foster St, Worcester, MA 01608, USA.

Black/African-American (B/AA) breast cancer patients tend to have more aggressive tumor biology compared to White/Caucasians. In this study, a variety of breast tumor molecular expression profiles of patients derived from the two racial groupings were investigated. Breast invasive carcinoma sample data (RNASeq version 2, Reverse Phase Protein Array, mutation, and miRSeq data) from the Cancer Genome Atlas were examined. Read More

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http://dx.doi.org/10.1016/j.gene.2020.100030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286073PMC
December 2020