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BMJ Case Rep 2022 Jun 27;15(6). Epub 2022 Jun 27.

Yale-Waterbury Internal Medicine Residency, Yale University School of Medicine, Waterbury, Connecticut, USA

A middle-aged woman presented with a mechanical fall. Physical examination revealed a massive purulent ulcerated lesion spanning her entire back and axilla, which had reportedly been brewing for over a decade. Punch biopsy revealed infiltrative basal cell carcinoma. Read More

Tissue Cell 2022 Jun 15;77:101856. Epub 2022 Jun 15.

Biophysics Department, Faculty of Science, Cairo University, Egypt.

Skin cancer is considered a risky worldwide disease. Traditional treatments have several weaknesses, necessitating the creation of more effective treatments. In this case, photodynamic therapy and nanotechnology were used to demonstrate their therapeutic efficacy as combinational approaches in treating different types of skin cancer. Read More

Histopathology 2022 Jun 27. Epub 2022 Jun 27.

Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.

The 5 edition of the WHO Classification of Tumours of the Urinary and Male Genital Systems encompasses several updates to the classification and diagnosis of prostatic carcinoma as well as incorporating advancements in assessment of its prognosis, including recent grading modifications. Some of the salient aspects include: 1) recognition that PIN-like carcinoma is not synonymous with a pattern of ductal carcinoma but better classified as a subtype of acinar adenocarcinoma; 2) a specific section on treatment-related neuroendocrine prostatic carcinoma in view of the tight correlation between androgen deprivation therapy and the development of prostatic carcinoma with neuroendocrine morphology, and the emerging data on lineage plasticity; 3) a terminology change of basal cell carcinoma to "adenoid cystic (basal cell) cell carcinoma" given the presence of an underlying MYB::NFIB gene fusion in many cases; 4) discussion of the current issues in the grading of acinar adenocarcinoma and the prognostic significance of cribriform growth patterns; and 5) more detailed coverage of intraductal carcinoma of prostate (IDC-P) reflecting our increased knowledge of this entity, while recommending the descriptive term atypical intraductal proliferation (AIP) for lesions falling short of IDC-P but containing more atypia than typically seen in high-grade prostatic intraepithelial neoplasia (HGPIN). Lesions previously regarded as cribriform patterns of HGPIN are now included in the AIP category. Read More

Actas Dermosifiliogr 2022 Jun 23. Epub 2022 Jun 23.

Servicio de Dermatología del Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, España. Electronic address:

J Am Acad Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Human-Computer Interaction, Hanyang University, Seoul, South Korea.

Background: Although various skin cancer detection devices have been proposed, most of them are not used owing to their insufficient diagnostic accuracies. Laser-induced plasma spectroscopy (LIPS) can noninvasively extract biochemical information of skin lesions using an ultrashort pulsed laser.

Objective: To investigate the diagnostic accuracy and safety of a real-time noninvasive in vivo skin cancer diagnostics utilizing non-discrete molecular LIPS combined with a deep neural network (DNN)-based diagnostic algorithm. Read More

Curr Opin Urol 2022 Jul;32(4):358-363

Department of Pathology, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: Due to the limited number of cases, there are no guidelines for basal cell carcinoma (BCC) of the prostate. This review combines an unpublished case report of a 55-year-old patient with BCC with an assessment of the latest literature.

Recent Findings: BCC of the prostate has previously been described in only approximately 140 cases. Read More

PLoS One 2022 24;17(6):e0268693. Epub 2022 Jun 24.

Department of Medicine, University of Chicago, Chicago, IL, United States of America.

Maternal embryonic leucine-zipper kinase (MELK) regulates cell cycle progression and is highly expressed in many cancers. The molecular mechanism of MELK dysregulation has not been determined in aggressive forms of breast cancer, such as triple negative breast cancer (TNBC). To evaluate molecular markers of MELK aberrations in aggressive breast cancer, we assessed MELK gene amplification and expression in breast tumors. Read More

Actas Dermosifiliogr 2022 Jun 11;113(6):T575-T582. Epub 2022 May 11.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain.

Familiarity with predictors of more aggressive behavior is crucial to the management of basal cell carcinoma (BCC). Risk factors for aggressive BCC are essentially divided into clinical and histopathologic factors. In this review we examine histopathologic features predictive of aggressiveness in BCC. Read More

J Pers Med 2022 Jun 16;12(6). Epub 2022 Jun 16.

State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.

Psoriasis and skin tumors (such as basal cell carcinoma, squamous cell carcinoma, and melanoma) are chronic diseases that endanger physical and mental health, and yet the causes are largely unknown and treatment options limited. The development of targeted drugs requires a better understanding of the exact pathogenesis of these diseases, and Yes-associated protein (YAP), a member of the Hippo signaling pathway, is believed to play an important role. Psoriasis and skin tumors are characterized by excessive cell proliferation, abnormal differentiation, vasodilation, and proliferation. Read More

J Clin Med 2022 Jun 15;11(12). Epub 2022 Jun 15.

Department of Dermatology I, Colentina Hospital, "Carol Davila" University of Medicine and Pharmacy, 19-21 Stefan Cel Mare Road, 020125 Bucharest, Romania.

Surgical excision is the standard treatment for basal cell carcinoma (BCC), but it can be challenging in elderly patients and patients with comorbidities. The non-surgical guidelines procedures are usually regarded as monotherapy options. This quasi-experimental, non-randomized, comparative effectiveness study aims to evaluate the efficacy of a combined, conservative, non-surgical BCC treatment, and compare it to standard surgical excision. Read More

J Clin Med 2022 Jun 11;11(12). Epub 2022 Jun 11.

Dermatology Clinic, Maggiore Hospital, University of Trieste, 34125 Trieste, Italy.

Background: Non-melanoma skin cancer (NMSC) stands as an umbrella term for common cutaneous malignancies, including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), together with rarer cutaneous cancers, such as Merkel cell carcinoma (MCC) and other forms of adnexal cancers. The majority of NMSCs can be successfully treated with surgery or radiotherapy, but advanced and metastatic stages may require systemic approaches such as immunotherapy with immune checkpoint inhibitors (ICIs).

Summary: Since immunotherapy is not effective in all patients and can potentially lead to severe adverse effects, an important clinical question is how to properly identify those who could be suitable candidates for this therapeutic choice. Read More

Diagnostics (Basel) 2022 Jun 13;12(6). Epub 2022 Jun 13.

Department of Dermatology, International University of Health and Welfare, Narita 286-8520, Chiba, Japan.

Nevus sebaceus is a benign tumor that is present at birth and is often seen on the scalp or face. Secondary malignant tumors sometimes occur in nevus sebaceus in adulthood. Herein, we present two malignant tumors arose from nevus sebaceus. Read More

Diagnostics (Basel) 2022 May 27;12(6). Epub 2022 May 27.

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India.

The heterogeneous nuclear ribonucleoprotein D (hnRNPD) serves as a prognostic marker for oral squamous cell carcinoma (OSCC). We evaluated the diagnostic potential of hnRNPD to differentiate between OSCC and normal mucosa. Immunohistochemistry for hnRNPD and a routinely used diagnostic marker deltaNp63 (p40) was performed in 32 normal mucosae and 46 OSCC specimens. Read More

Biomolecules 2022 Jun 2;12(6). Epub 2022 Jun 2.

Department of Medical and Surgical Sciences, University of Catania, 95123 Catania, Italy.

Nevoid basal cell carcinoma syndrome (NBCCS) associated odontogenic keratocysts (OKCs) show more aggressive behavior and it has a higher frequency of relapse than non-syndromic OKCs. Stromal myofibroblasts (MFs), characterized by α-smooth muscle actin (αSMA), desmin and caldesmon expression, and metalloproteinases (MMPs) have an essential role in the remodeling of the extracellular matrix (ECM). The aim of the study is to analyze the immunohistochemical expression of MMP-7, MMP-9, αSMA and other new markers in the study of OKCs MFs such as desmin and caldesmon in NBCCS-associated OKCs compared to recurrent and sporadic keratocysts. Read More

Cancers (Basel) 2022 Jun 8;14(12). Epub 2022 Jun 8.

Dermatologic Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.

Background/objectives: Non-melanoma skin cancer (NMSC) treated with nonsurgical therapies can be monitored with noninvasive skin imaging. The precision of dermoscopy, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) in detecting clearance is unclear. We aim to report the proportion of persisting tumors identified with noninvasive technologies available in the literature. Read More

Cancers (Basel) 2022 Jun 7;14(12). Epub 2022 Jun 7.

Centro de Investigaciones Inmunológicas Básicas y Aplicadas (CINIBA), Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata 1900, Argentina.

Long non-coding RNAs are increasingly being recognized as cancer biomarkers in various malignancies, acting as either tumor suppressors or oncogenes. The long non-coding intergenic RNA was identified as significantly upregulated in breast ductal carcinoma in situ. The aim of this study was to characterize expression, localization, and phenotypic and molecular effects in non-invasive and invasive breast cancer cells. Read More

Ned Tijdschr Geneeskd 2022 05 31;166. Epub 2022 May 31.

Maastricht UMC+, afd. Dermatologie, Maastricht.

Basal cell carcinoma (BCC) is the most common cancer type in the Netherlands and frequently diagnosed in older adults. Unlike other common forms of skin cancer (squamous cell carcinoma and melanoma), BCC generally grows slowly and the risk of metastasis and/or death is extremely small. In the first years after presentation, BCC often causes no or only minor complaints. Read More

Dermatopathology (Basel) 2022 Jun 18;9(2):183-195. Epub 2022 Jun 18.

Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania.

: Basal carcinoma of the skin (BCC) is part of the nonmelanoma skin cancer (NMSC) family and is the most frequently occurring type of skin cancer in humans. A combination of clinical and histopathological approaches is necessary in order to establish the best treatment regime for patients who have been diagnosed with this type of cancer. The objective of the present study was to establish the statistical value of prediction for certain sociodemographic characteristics (age category and environment of origin) and histopathological parameters of the subjects that could be related to the incidence of diagnosis with certain histopathological subtypes of BCC. Read More

Future Cardiol 2022 Jun 23. Epub 2022 Jun 23.

Cardiovascular Disease, University of Michigan-West, Wyoming, 49519, Michigan.

Gorlin-Goltz syndrome is a rare autosomal dominant disease characterized by odontogenic keratocysts and basal cell carcinoma as well as ophthalmic and neurological implications. The following article presents the case of a 20-year-old female with Gorlin-Goltz syndrome incidentally found to have a cardiac mass. An ECG showed diffuse T-wave inversions in the lateral leads despite a lack of any acute coronary symptoms in the patient. Read More

Future Oncol 2022 Jun 23. Epub 2022 Jun 23.

Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.

To examine real-world treatment patterns for Hedgehog pathway inhibitors (HHIs) for the treatment of advanced basal cell carcinoma. HHI initiators between January 2013 and June 2019 were identified from IBM MarketScan claims data. Time to treatment discontinuation and reinitiation were estimated using Kaplan-Meier methods using a 60-day grace period. Read More

Ann Med Surg (Lond) 2022 Jun 26;78:103877. Epub 2022 May 26.

Mansoura Dermatology, Venerology and Leprology Hospital, Mansoura, Egypt.

Background: Recurrence of basal cell carcinoma (BCC) after complete surgical excision is rarely reported. Risk factors for this negative outcome are not well-studied. We present the clinical and histological features of recurrent BCCs in our institution. Read More

Curr Res Toxicol 2022 13;3:100079. Epub 2022 Jun 13.

Department of Environmental Sciences, University of California, Riverside, CA, USA.

Tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA) - both halogenated bisphenol (BPA) analogues - are suspected ligands of peroxisome proliferator-activated receptor gamma (PPARγ). While previous studies have shown that TBBPA and TCBPA activate PPARγ within cell-free assays, the downstream effects of TBBPA- and TCBPA-induced PPARγ activation on cellular transcription and physiology have not been thoroughly investigated. Therefore, the objective of this study was to determine whether exposure to TBBPA or TCBPA (either alone or in combination) alters levels of neutral lipids and fatty acid synthase (FASN) - an enzyme that catalyzes synthesis of long-chain saturated fatty acids - within intact cells in a PPARγ-dependent manner. Read More

Mol Cancer Ther 2022 Jun 23. Epub 2022 Jun 23.

Rutgers, The State University of New Jersey, New Brunswick, United States.

Only a small percentage (< 1%) of patients with late-stage lung squamous cell carcinoma (LUSC) are eligible for targeted therapy. Because PI3K/AKT/mTOR signaling, particularly PIK3CA, is dysregulated in two-thirds of LUSC, and DNA damage response pathways are enriched in LUSC, we tested whether CC-115, a dual mTORC1/2 and DNA-PK inhibitor, sensitizes LUSC to chemotherapy. We demonstrate that CC-115 synergizes with carboplatin in 6 of 14 NSCLC cell lines, primarily PIK3CA-mutant LUSC. Read More

Acta Otolaryngol 2022 Jun 22:1-5. Epub 2022 Jun 22.

Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan.

Background: External auditory canal (EAC) squamous cell carcinoma (SCC) is a rare disease, and the survival rate is low in the advanced stages. It has been reported that miR-34a expression is low in many cancers and acts as a tumor suppressor, but its function in EACSCC has not yet been reported.

Aims: To analyze the miR-34a expression levels in EACSCC specimens using hybridization (ISH). Read More

Oncol Ther 2022 Jun 21. Epub 2022 Jun 21.

Department of Histopathology, University Hospital Dorset NHS Foundation Trust, Bournemouth, UK.

Basal cell carcinoma (BCC) is the most common, accounting for 80-90% of skin cancers. It arises from the basal layer of the epidermis and its appendages. A complex interplay of environmental, phenotypic and genetic variables leads to the development of BCC. Read More

Eye (Lond) 2022 Jun 21. Epub 2022 Jun 21.

The Sussex Eye Hospital, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.

Caruncle malignancy is rare, but signs of disease can be easily missed by both patients and clinicians. There is significant potential for significant morbidity and even mortality from delayed diagnosis and treatment. Clinical features of primary malignant cancer include rapid growth, pigment deposition, ulcerated surface and bleeding. Read More

J Immunother Cancer 2022 Jun;10(6)

Mozart Therapeutics, Seattle, Washington, USA

Background: Human immune cells, including monocyte-derived macrophages, can be engineered to deliver proinflammatory cytokines, bispecific antibodies, and chimeric antigen receptors to support immune responses in different disease settings. When gene expression is regulated by constitutively active promoters, lentiviral payload gene expression is unregulated, and can result in potentially toxic quantities of proteins. Regulated delivery of lentivirally encoded proteins may allow localized or conditional therapeutic protein expression to support safe delivery of adoptively transferred, genetically modified cells with reduced capacity for systemic toxicities. Read More

J Am Acad Dermatol 2022 Jun 18. Epub 2022 Jun 18.

Department of Dermatology, Stanford University School of Medicine, Stanford, California. Electronic address:

J Craniofac Surg 2022 May 26;33(3):892-894. Epub 2021 Oct 26.

Ningbo City First Hospital, Ningbo, China.

Background: Large benign and malignant tumors in the scalp cannot be sutured directly after resection. Instead, skin grafting or skin flap repair is the most commonly used techniques. Local tissue depression and lack of hair growth are some of the drawbacks associated with these techniques. Read More

Int J Dermatol 2022 Jun 21. Epub 2022 Jun 21.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Background: Recent large cohorts have reported that melanoma survivors are at risk of developing second keratinocyte carcinoma (KC). However, the detailed proportion and risk are still unknown. We aimed to comprehensively analyze the risk of developing keratinocyte carcinoma after primary melanoma. Read More