Search Our Scientific Publications & Authors

Mol Clin Oncol 2021 Apr 9;14(4):69. Epub 2021 Feb 9.

Department of Obstetrics and Gynecology, 'G. Chatzikosta' General Hospital, Ioannina 45001, Epirus, Greece.

Vulvar sarcomas located in the Bartholin's gland area are extremely uncommon mesenchymal vulvar tumors. These neoplasms can be mistaken as Bartholin' gland benign lesions such as cysts or abscesses, leading to a delay in the diagnosis of underlying malignancy. Currently, only a few cases of these aggressive cancers have been reported in the literature. Read More

Prz Menopauzalny 2020 Dec 7;19(4):184-187. Epub 2021 Jan 7.

Saint Marina University Hospital, Medical University Pleven, Pleven, Bulgaria.

Introduction: Leiomyosarcoma of the vulva is a rare disease accounting for about 1% of all primary vulvar neoplasia but it is the most common type of vulvar sarcomas. Usually it arises from the smooth muscles, blood vessels, rough ligaments, and erector-pili muscles. No treatment algorithms have been established yet. Read More

Oral Dis 2021 Jan 11. Epub 2021 Jan 11.

Department of Odontology, Section for Oral Biology and Immunopathology, Oral Medicine and Pathology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.

Objectives: A lifelong gluten-free (GF) diet ameliorates autoimmune diabetes in non-obese diabetic (NOD) mice and most likely in humans. Besides diabetes, NOD mice develop focal sialadenitis, as seen in Sjögren's syndrome (SS). In humans, type 1 diabetes (T1D) is also linked to SS. Read More

BMJ Case Rep 2021 Jan 11;14(1). Epub 2021 Jan 11.

Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.

Primary Bartholin gland carcinoma (BGC) is an extremely rare disease. It typically presents in elderly women. It can be confused with Bartholin gland cyst, which is a benign condition leading to a delay in diagnosis and treatment. Read More

Rev Fac Cien Med Univ Nac Cordoba 2020 12 13;77(4):345-350. Epub 2020 Dec 13.

Estudiante de internado - CAJA NACIONAL DE SALUD-Universidad Mayor de San Andrés.

Introduction: Bartholin's glands, also known as major vestibular glands, are responsible for a large number of gynecological diseases of the vulva. Bartholin's gland cysts and abscesses can present with different symptoms and the required surgical management should be marsupialization and not incision and drainage. Although the incision and drainage procedure was shown to be relatively quick and easy to perform, and the cure rate is rapid among patients receiving this type of surgical technique, it has nevertheless been shown that the recurrence trend has increased. Read More

Semin Diagn Pathol 2021 Jan 25;38(1):71-84. Epub 2020 Sep 25.

Department of Pathology, Anatomic Pathology Division, University of California San Diego Health, La Jolla, CA.

Approximately half of adenocarcinomas that involve the vulva are secondary, either through direct extension or metastases from elsewhere. Primary vulvar adenocarcinomas are rare and encompass a diverse array of neoplasms that are nominally classified based on the presumed tissue or organ of origin, the tumoral phenotype, or both. In this review, we summarize the clinicopathologic features of adenocarcinomas that originate from the vulva and related structures, including the terminal urethra. Read More

J Pak Med Assoc 2020 Aug;70(8):1445-1447

Aga Khan University Hospital, Karachi, Pakistan.

Adenoid cystic carcinoma of the Bartholin gland is a rare vulval cancer. Available literature suggests an aggressive nature with protracted clinical symptoms and local recurrence despite adequate surgical excision with or without adjuvant radiotherapy. This case demonstrates the role of neoadjuvant chemotherapy and interstitial brachytherapy with less radical surgery, in the treatment of adenoid cystic carcinoma of the Bartholin gland. Read More

J Med Case Rep 2020 Jul 1;14(1):85. Epub 2020 Jul 1.

Department of Gynaecology, Erasmus MC, Wytemaweg 80, Rotterdam, 3015 CN, The Netherlands.

Background: In this case report we present a case of endometriosis in the Bartholin gland without surgery in the perineal area. So far, only five cases concerning endometriosis in the Bartholin gland, which may or may not be an isolated finding, have been reported in the literature.

Case Presentation: A 31-year-old Indo-surinamese woman with primary infertility presented at our out-patient clinic with cyclical vulvar pain. Read More

Diagn Pathol 2020 May 28;15(1):64. Epub 2020 May 28.

Genomics Unit, Keio Cancer Center, Keio University School of Medicine, 35 Shinanomachi, Shinjukuku, Tokyo, 160-8582, Japan.

Background: Bartholin gland carcinomas (BGCs) are rare tumor types, for which no molecular analyses including genomic sequencing have been reported to date. Adenoid cystic carcinomas (ACCs) of the Bartholin's glands are an atypical histological type of BGC, and currently nothing is known regarding their genetic profiles or similarity to ACC carcinogenesis in other organs including the salivary glands, thereby limiting possible therapeutic options using precision medicine.

Case Presentation: We used targeted gene sequencing to analyze the occurrence of 160 cancer-related genes in two patients with BG-ACC. Read More

Oncology 2020 14;98(8):513-519. Epub 2020 May 14.

National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.

Background and summary: Among all vulvar cancers, primary adenoid cystic carcinoma (ACC) of Bartholin's gland is a very rare tumor characterized by a slow growth, a high local aggressiveness, and a remarkable recurrence rate. Due to its rarity, treatment remains a challenge for oncologists and gynecological surgeons. Key message: The present paper reports clinical, radiological, and histological features of ACC of Bartholin's gland and reviews the literature data on the treatment options with a particular focus on the potential role of particle radiation therapy. Read More

J Gynecol Obstet Hum Reprod 2020 Apr 20;49(4):101689. Epub 2020 Jan 20.

Department of Gynaecology and Obstetrics, CIC, centre d'investigation clinique de Nantes, Hôpital Mère-Enfant, Nantes University Hospital, 38 Boulevard Jean Monnet, 44000 Nantes, France; Nantes Faculty of Medicine, 1 Rue Gaston Veil, 44000, Nantes, France.

Introduction: Bartholin's gland abscesses cause severe pain and are a source of frequent emergency room visits. The most widespread treatment in France is incision-drainage during hospitalisation. A Word catheter, whose efficiency and safety would be identical, could be used without the need for hospitalisation, thus reducing the costs of Bartholin's gland abscess management. Read More

BJOG 2020 05 4;127(6):671-678. Epub 2020 Feb 4.

Institute for Women's Health, University College London, London, UK.

Background: No consensus on the management of symptomatic cysts or abscesses of the Bartholin's gland exists.

Objectives: To assess the effectiveness and safety of surgical interventions for a symptomatic Bartholin's cyst or abscess.

Search Strategy: We searched bibliographical databases from inception to April 2019. Read More

Medicine (Baltimore) 2019 Sep;98(39):e17043

Department of Obstetrics & Gynaecology, West China Second Hospital.

Rationale: Post-hysterectomy collision tumors of the vulva has rarely been reported. Though long-term HPV infection may induce vulva tumor, but the relationship between HPV infection and collision vulva tumor is not clear. And there are no clear rules of the post-hysterectomy cancer surveillance for human papilloma virus (HPV) long-term infections. Read More

Emerg Med Clin North Am 2019 Nov;37(4):771-784

Emergency/Internal/Critical Care Medicine, University of Maryland, 110 South Paca Street, 6th Floor, Suite 200, Baltimore, MD 21201, USA. Electronic address:

The emergency medicine provider sees a broad range of pathology involving the female genitourinary system on a daily basis. Must-not-miss diagnoses include pelvic inflammatory disease and ovarian torsion, because these diagnoses can have severe complications and affect future fertility. Although most patients with abnormal uterine bleeding are hemodynamically stable, it can present as a life-threatening emergency and providers should be adept managing severe hemorrhage. Read More

Gynecol Obstet Fertil Senol 2019 10 26;47(10):713-717. Epub 2019 Jul 26.

Pôle de gynécologie-obstétrique, maternité régionale universitaire, CHRU de Nancy, 10, rue du Docteur Heydenreich, 54000 Nancy, France.

Objectives: Acute Bartholinitis is a common pathology affecting nearly 2% of women in their lifetime. Many treatments are used, although their effectiveness is not demonstrated in the literature. The main objective was to evaluate the success rate of first-line antibiotic therapy. Read More

Int J Gynecol Pathol 2020 Sep;39(5):443-446

Department of Pathology, Stanford University School of Medicine, Stanford, California.

Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease (RDD), is a self-limited histiocytic disorder of unclear etiology which most commonly presents with cervical lymphadenopathy. Purely extranodal presentation of RDD is uncommon, and isolated intralymphatic/intravascular confinement of this entity has not previously been described. We report a 16-yr-old female who presented with vaginal swelling and mass-like enlargement of the right labia. Read More

Diagn Pathol 2019 Jun 26;14(1):66. Epub 2019 Jun 26.

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Background: Pseudomyogenic hemangioendothelioma (PMHE) is a recently described vascular neoplasm which typically occurs in the lower extremities of young to middle-aged adults.

Case Presentation: We present here a unique case of PMHE arising primarily in the vulva of a 51-year-old woman who presented with a painful vulvar nodule. Clinically, it was thought as Bartholin gland cyst, vulvar hematoma or papilloma. Read More

Int Cancer Conf J 2019 Apr 14;8(2):89-93. Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, Steel Memorial Yahata Hospital, Kitakyushu, Japan.

Primary adenocarcinoma of the vulva is a rare disease, and usually arises in a Bartholin gland or occurs in association with Paget's disease. Furthermore, adenocarcinoma of intestinal type of the vulva is an extremely rare neoplasm, and few cases have been reported. The appropriate treatment for optimal prognosis is unclear. Read More

BMJ Case Rep 2019 Apr 24;12(4). Epub 2019 Apr 24.

Department of Clinical Pathology Service, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Coimbra, Portugal.

Gynaecological infections are frequent in women, particularly in young women during their reproductive time. Anatomophysiologically, Bartholin's gland is greatly susceptible to infections and is characterised by an inherent polymicrobial population. In fact, gynaecological microbiota has a set of agents coming from the perianal region that colonise the vagina and, in particular, Bartholin's gland. Read More

J Gynecol Obstet Hum Reprod 2019 Oct 29;48(8):631-635. Epub 2019 Mar 29.

Department of Gynecology-Obstetrics and Reproductive Medecine, 38 boulevard Jean Monnet, 44000, Nantes, France; Nantes Medical University, France. Electronic address:

Objectives: To assess the methods used to manage Bartholin gland abscesses and cysts in French university hospitals.

Method: Data for this descriptive, cross-sectional study with self-reported data were collected between January and March 2018 by an online questionnaire. The 11 items of the questionnaire assessed the surgical techniques known and used, the type of hospitalization, and the non-surgical management to treat Bartholin gland abscesses and cysts. Read More

J Midwifery Womens Health 2019 May 7;64(3):337-343. Epub 2019 Feb 7.

Bartholin duct cysts and gland abscesses can affect a woman's day-to-day functioning and be challenging to manage. Many Bartholin duct cysts that are not infected remain asymptomatic and resolve spontaneously without intervention. However, an infected Bartholin duct cyst or glandular abscess should be drained when larger than 2 cm because such cysts or abscesses do not tend to resolve spontaneously and can recur. Read More

Adv Emerg Nurs J 2019 Jan/Mar;41(1):39-42

Mayo Clinic Simulation Center, Jacksonville, Florida (Ms Lannen); Department of Obstetrics & Gynecology, Mayo Clinic, Jacksonville, Florida (Dr Destephano); and Vanderbilt University School of Nursing, Nashville, Tennessee (Dr Wilbeck).

For women who present with Bartholin's abscesses, placement of a Word catheter offers a minimally invasive approach for effective management in urgent care and emergency department settings. Although the procedure is relatively simple, the frequency of placement in the ED setting varies. Provider familiarity with both the device and the procedure can be enhanced using simulation techniques. Read More

Eur J Obstet Gynecol Reprod Biol 2018 Nov 4;230:188-191. Epub 2018 Oct 4.

Kanuni Sultan Suleyman Research and Training Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey.

Objective: To compare sexual function scores in patients who had marsupialization and gland excision procedures for the treatment of Bartholin gland abscesses.

Study Design: Patients who had bartholin abscess for the first time were randomized into marsupialization or gland excision methods. The primary outcome was to compare post surgical Female Sexual Function Index (FSFI) scores between the marsupialization group and the excision group. Read More

Gynecol Endocrinol 2019 Feb 22;35(2):150-154. Epub 2018 Aug 22.

a Department of Gynecological, Obstetrical and Urological Sciences , ' Sapienza' University of Rome , Rome , Italy.

The aim of this study is to evaluate the sexual functionality before and after treatment of Bartholin's gland diseases (BGD) with CO laser and to compare our results to patients who underwent surgical cold knife and to a healthy control group (HCG). Consecutive patients (n = 15) affected by BG cyst or abscess who underwent CO laser treatment were evaluated. Patients were asked to complete the Italian translation of the Female Sexual Functioning Index (FSFI) before and 4 weeks after treatment. Read More

Case Rep Obstet Gynecol 2018 26;2018:5256876. Epub 2018 Mar 26.

University of Queensland, Brisbane, QLD, Australia.

Adenoid cystic carcinoma of the Bartholin Gland (BG-ACC) is a rare form of vulval cancer with only approximately 350 reported cases since 1864. A review of available literature and case reports suggests an aggressive nature with protracted clinical symptoms and a tendency for local recurrence despite adequate surgical excision with or without adjuvant radiotherapy. Survival rates of 71% and 59% are reported at five and ten years. Read More

Int J Gynecol Pathol 2019 Mar;38(2):189-195

Department of Pathology and Laboratory Medicine (T.N., A.S.C., A.N.K., C.B.G.) Genetic Pathology Evaluation Centre (A.S.C.), University of British Columbia Division of Anatomical Pathology, Vancouver General Hospital (T.N., A.N.K., C.B.G.) Division of Medical Oncology, British Columbia Cancer Agency (A.T.), Vancouver, British Columbia, Canada.

Bartholin gland carcinomas are rare forms of vulvar malignancy and it is unclear what proportion is associated with high-risk human papilloma virus (HPV) infection. Our hospital archives were searched for all cases of Bartholin gland carcinoma from 1984 to 2017 (n=16). We excluded 3 adenoid cystic carcinomas, which were the subject of a previous study, leaving 13 cases. Read More

Rom J Morphol Embryol 2018 ;59(4):1233-1237

Department of Obstetrics and Gynecology, "Polizu" Clinical Hospital, "Alessandrescu-Rusescu" National Institute for Healthcare of Mother and Child, Bucharest, Romania;

Clear cell carcinoma (CCC) of the female genital tract usually arises in the ovary, endometrium, cervix and vagina. A rare site for CCC is the vulva, and moreover even rarer are the cases involving the Bartholin gland. A 54-year-old female was admitted for a 1. Read More

Gynecol Oncol 2017 12 28;147(3):723-724. Epub 2017 Sep 28.

Department of Gynecology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.

Objective: Some sections of the pelvic bone can be removed without severe loss of function, including the inferior pubic ramus. Here we report a technique for the complete resection of locally advanced adenoid cystic carcinoma (ACC) of the Bartholin's gland that had invaded the obturator muscle and inferior pubic ramus.

Methods: We chose to operate because there was little evidence of definitive radiotherapy for ACC of the vulva. Read More

Int J Gynecol Pathol 2018 Nov;37(6):554-558

Department of Pathology and Microbiology (Y.A.T.), University of Nebraska Medical Center, Omaha, Nebraska; Department of Pathology and Laboratory Medicine (Y.A.T., W.D.L., S.E.S.), The Warren Alpert Medical School of Brown University and Women & Infants Hospital, Providence, Rhode Island.

Nodular hyperplasia (NH) of the Bartholin gland is an exceedingly rare benign solid lesion of the female genital tract that can mimic the Bartholin gland cyst clinically. The histologic criteria for NH were established in 1998 by Koenig and Tavassoli. In this case series, we describe 4 cases of NH from Women and Infants Hospital in Rhode Island. Read More

Crit Rev Oncol Hematol 2017 09 13;117:1-11. Epub 2017 Jun 13.

Department of Gynecological, Obstetrical and Urological Sciences, "Sapienza" University of Rome, Italy.

Introduction: Bartholin gland carcinoma is an extremely rare condition. Because of its, phase III trials have not been carried out, there exists no unanimous consensus on treatment and guidelines are missing.

Methods: All studies reporting cases of Bartholin cancer were collected and screened for the evaluations. Read More