25,945 results match your criteria Barrett Esophagus and Barrett Ulcer


Classic Psychedelics: An integrative review of epidemiology, mystical experience, brain network function, and therapeutics.

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences; Johns Hopkins University School of Medicine, Department of Neuroscience.

The purpose of this paper is to provide an integrative review and offer novel insights regarding human research with classic psychedelics (classic hallucinogens), which are 5HT2AR agonists such as lysergic acid diethylamide (LSD), mescaline, and psilocybin. Classic psychedelics have been administered as sacraments since ancient times. They were of prominent interest within psychiatry and neuroscience in the 1950s to 1960s, and during this time contributed to the emergence of the field of molecular neuroscience. Read More

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December 2018
1 Read

The elimination of human African trypanosomiasis is in sight: Report from the third WHO stakeholders meeting on elimination of gambiense human African trypanosomiasis.

PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006925. Epub 2018 Dec 6.

Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.

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December 2018

Use of geosocial networking applications is independently associated with diagnosis of STI among men who have sex with men testing for STIs: findings from the cross-sectional MSM Internet Survey Ireland (MISI) 2015.

Sex Transm Infect 2018 Dec 5. Epub 2018 Dec 5.

Health Protection Surveillance Centre, Dublin, Ireland.

Objectives: MSM Internet Survey Ireland (MISI) 2015 was an anonymous, self-completed, cross-sectional internet survey assessing sexual behaviours and health needs among men who have sex with men (MSM) in Ireland. We explored factors associated with self-reported STI diagnosis among MSM who were sexually active and had an STI test in the previous year.

Methods: We compared the study population (n=1158; 37% of total population), with the sexually active MISI population not testing for STIs (n=1620; 52% of total population). Read More

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December 2018

PM Filter Extraction Methods: Implications for Chemical and Toxicological Analyses.

Environ Sci Technol 2018 Dec 3. Epub 2018 Dec 3.

Toxicology research into the global public health burden of fine particulate matter (PM) exposures frequently requires extraction of PM from filters. A standardized method for these extractions does not exist, leading to inaccurate inter-laboratory comparisons. It is largely unknown how different filter extraction methods might impact the composition and bioactivity of the resulting samples. Read More

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December 2018

Are there sex effects for speech intelligibility in American English? Examining the influence of talker, listener, and methodology.

Atten Percept Psychophys 2018 Nov 30. Epub 2018 Nov 30.

Department of Communicative Disorders and Deaf Education, Utah State University, Logan, UT, 84322, USA.

Talker and listener sex in speech processing has been largely unknown and under-appreciated to this point, with many studies overlooking the possible influences. In the current study, the effects of both talker and listener sex on speech intelligibility were assessed. Different methodological approaches to measuring intelligibility (percent words correct vs. Read More

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November 2018

Efficient Exploration of Many Variables and Interactions Using Regularized Regression.

Prev Sci 2018 Nov 30. Epub 2018 Nov 30.

Department of Psychology, Utah State University, 2810 Old Main Hill, Logan, UT, 84322, USA.

The prevention sciences often face several situations that can compromise the statistical power and validity of a study. Among these, research can (1) have data with many variables, sometimes with low sample sizes, (2) have highly correlated predictors, (3) have unclear theory or empirical evidence related to the research questions, and/or (4) have difficulty selecting the proper covariates in observational studies. Modeling in these situations is difficult-and at times impossible-with conventional methods. Read More

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November 2018

Assessing subtypes of restricted and repetitive behaviour using the Adult Repetitive Behaviour Questionnaire-2 in autistic adults.

Mol Autism 2018 26;9:58. Epub 2018 Nov 26.

1Wales Autism Research Centre, School of Psychology, Cardiff University, Cardiff, UK.

Background: The majority of previous research into restricted and repetitive behaviours (RRBs) has focussed on children, partly due to a lack of suitable measures for RRBs in adults. This study aimed to explore the psychometric properties of the Adult Repetitive Behaviour Questionnaire-2 (RBQ-2A) in a large sample of autistic adults using a self-report questionnaire method.

Methods: The RBQ-2A and Autism-Spectrum Quotient (AQ) were administered online. Read More

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November 2018

Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish.

Blood Adv 2018 Dec;2(23):3418-3427

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.

The NFE2 transcription factor is expressed in multiple hematopoietic lineages with a well-defined role in regulating megakaryocyte biogenesis and platelet production in mammals. Mice deficient in NFE2 develop severe thrombocytopenia with lethality resulting from neonatal hemorrhage. Recent data in mammals reveal potential differences in embryonic and adult thrombopoiesis. Read More

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December 2018

Differences in fetal growth patterns between twins and singletons.

J Matern Fetal Neonatal Med 2018 Dec 2:1-201. Epub 2018 Dec 2.

b Division of Maternal-Fetal Medicine , Department of Obstetrics and Gynecology , Sunnybrook Health Sciences Center , and University of Toronto , Toronto , Canada.

Objective: Twin fetuses growth is delayed during the third trimester compared to singletons. Whether this phenomenon should be considered a normal physiologic characteristic of twins or a pathologic process inherent to twin pregnancies is currently unclear. Information on the growth rate of the individual fetal biometric indices may provide more insight into the mechanisms underlying these differences between twins and singletons. Read More

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December 2018

Drug use among men who have sex with men in Ireland: Prevalence and associated factors from a national online survey.

Int J Drug Policy 2018 Dec 1;64:5-12. Epub 2018 Dec 1.

Health Protection Surveillance Centre, Dublin, Ireland.

Background: Little is known about the prevalence and determinants of drug use among men who have sex with men (MSM) in Ireland. The aims of this study were to measure the prevalence of recreational drug use among MSM in a national sample, and to identify sub-groups of MSM who may benefit from targeted preventive interventions.

Methods: The MSM Internet Survey Ireland (MISI) 2015 was a community-recruited, nationally-promoted, self-completed online survey for MSM. Read More

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December 2018
2 Reads

Documenting metrological traceability as intended by ISO 15189:2012: A consensus statement about the practice of the implementation and auditing of this norm element.

Clin Chem Lab Med 2018 Dec 4. Epub 2018 Dec 4.

Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milano Medical School, Research Centre for Metrological Traceability in Laboratory Medicine (CIRME), Milan, Italy.

ISO15189:2012 requires medical laboratories to document metrological traceability of their results. While the ISO17511:2003 standard on metrological traceability in laboratory medicine requires the use of the highest available level in the traceability chain, it recognizes that for many measurands there is no reference above the manufacturer's selected measurement procedure and the manufacturer's working calibrator. Some immunoassays, although they intend to measure the same quantity and may even refer to the same reference material, unfortunately produce different results because of differences in analytical selectivity as manufacturers select different epitopes and antibodies for the same analyte. Read More

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December 2018
2 Reads

Massive hemorrhage protocol activation in obstetrics: a 5-year quality performance review.

Int J Obstet Anesth 2018 Nov 3. Epub 2018 Nov 3.

Department of Transfusion Medicine.

Background: A structured approach to hemorrhagic emergencies in obstetrics has gained popularity with the implementation of massive hemorrhage protocols. The trauma literature suggests that routine quality reviews should be in place to improve patient outcomes. The aim of this study was to develop quality indicators and assess compliance by the clinical team. Read More

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November 2018

Specificity and variability of trunk kinematics on a mechanical horse.

Hum Mov Sci 2018 Nov 29;63:82-95. Epub 2018 Nov 29.

Baylor University, One Bear Place #97356, Waco, TX 76798, United States.

As perturbation training is gaining popularity, it is important to better understand postural control during complex three-dimensional stimuli. One clinically relevant and commonly used three-dimensional stimulus is found in hippotherapy and simulated hippotherapy on a mechanical horse. We tested nine healthy participants on a horse simulator, measured head and trunk kinematics, and characterized data in time (root-mean-square and variability) and frequency (amplitude spectra, gains, and phases) domains. Read More

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November 2018

Using prognosis to guide early detection and treatment selection in non-metastatic prostate cancer.

BJU Int 2018 Nov 30. Epub 2018 Nov 30.

Translational Prostate Cancer Group, CRUK Cambridge Cancer Centre, Cambridge, United Kingdom.

Over recent years there has been an increasing awareness that our ideas on the lethality of primary non-metastatic prostate cancer may need to change. This concept has emerged from a number of different sources including randomised controlled trials, reports from mature active surveillance programmes and prognostic modelling work in large populations (1-2). The evidence suggests that for many men without metastatic disease (85% of all presentations from the recent UK National Prostate Cancer Audit) tumours will evolve slowly and will not translate into cancer related mortality, at least, not within the first 10-15 years of its natural history. Read More

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November 2018

Response to Letter to the Editor From Mr. Russell Greene of CrossFit Inc.

Mil Med 2018 Nov;183(11-12):264-265

Department of Military and Emergency Services, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD.

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November 2018

Human Wharton's Jelly Mesenchymal Stem Cells Show Unique Gene Expression Compared to Bone Marrow Mesenchymal Stem Cells Using Single-Cell RNA-Sequencing.

Stem Cells Dev 2018 Nov 28. Epub 2018 Nov 28.

National University of Singapore, Obstetrics and Gynaecology, Singapore ;

Human Wharton's jelly stem cells (hWJSCs) isolated from the human umbilical cord are a unique population of mesenchymal stem cells with significant clinical utility. Their broad differentiation potential, high rate of proliferation, ready availability from discarded cords, and prolonged maintenance of stemness properties in culture make them an attractive alternative source of MSCs with therapeutic value compared to bone marrow MSCs (hBMMSCs). We aimed to characterise the differences in gene expression profiles between these two stem cell types using single-cell RNA sequencing (scRNA-Seq) to determine which pathways are involved in conferring hWJSCs with their unique properties. Read More

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November 2018

The incidence of esophageal cancer and dysplasia in a Chinese population with nondysplastic Barrett's esophagus.

JGH Open 2018 Oct 9;2(5):214-216. Epub 2018 Aug 9.

Division of Gastroenterology, Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan.

Aim: The aim of this study was to investigate the incidence of dysplastic transformation of Barrett's esophagus (BE) in a Chinese population.

Method: Data from nondysplastic BE patients at Taichung Veterans General Hospital were collected from May 2008 to June 2017. The enrolled individuals received regular upper gastrointestinal (UGI) endoscopy during follow up. Read More

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October 2018
3 Reads

Adiponectin level changes among Egyptians with gastroesophageal reflux disease.

JGH Open 2018 Feb 28;2(1):21-27. Epub 2018 Jan 28.

Department of Internal Medicine, Faculty of Medicine AL-Azhar University Assiut Egypt.

Background And Aim: Visceral fat is an important endocrine organ that secretes different bioactive substances such as adipocytokines. The aim of this study was to investigate the adiponectin level changes among patients with erosive gastroesophageal reflux disease (GERD)and its consequence on pathogenesis.

Methods: In this study, 150 subjects were selected and divided into four groups: Group І ( = 40) were healthy individuals with an average body mass index and had no gastrointestinal tract symptoms; Group ІІ ( = 50) were patients with mild to moderate erosive esophagitis; Group ІІІ ( = 40) were patients with severe erosive esophagitis; and finally, Group ІV ( = 20) were patients with Barrett's esophagus. Read More

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February 2018
3 Reads

Risk stratifying the screening of Barrett's esophagus: An Asian perspective.

JGH Open 2017 Oct 11;1(2):68-73. Epub 2017 Oct 11.

Department of Medicine National University Hospital Singapore.

Background And Aim: Barrett's esophagus (BE) is a premalignant condition for esophageal adenocarcinoma. Although risk factors exist for screening patients in the West, we aimed to determine the factors in terms of demographics and symptoms for patients in an Asian setting.

Methods: We recruited 1378 patients over a 7-year period as part of an ongoing gastric cancer screening program. Read More

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October 2017

American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy.

Blood Adv 2018 Nov;2(22):3317-3359

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.

Background: Venous thromboembolism (VTE) complicates ∼1.2 of every 1000 deliveries. Despite these low absolute risks, pregnancy-associated VTE is a leading cause of maternal morbidity and mortality. Read More

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November 2018
4 Reads

Clinical correlates of subsyndromal depression in African American individuals with psychosis: The relationship with positive symptoms and comorbid substance dependence.

Schizophr Res 2018 Oct 26. Epub 2018 Oct 26.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA.

Patients with psychosis exhibit subsyndromal depressive symptoms during the course of illness and yet the clinical correlates of these symptoms remain under-investigated. We aimed to investigate the clinical correlates of subsyndromal depression in psychosis including the extent to which they mediate commonly observed comorbid substance dependence. We developed a model of depression in a non-clinical sample recruited via Amazon's Mechanical Turk (N = 266), and confirmed that model in a locally recruited African-American clinical sample comprising psychotic and non-psychotic individuals (N = 256). Read More

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October 2018
1 Read

Effect of Cultural, Folk, and Religious Beliefs and Practices on Delays in Diagnosis of Ovarian Cancer in African American Women.

J Womens Health (Larchmt) 2018 Nov 27. Epub 2018 Nov 27.

13 Department of Public Health Sciences, University of Virginia , Charlottesville, Virginia.

Background: Certain cultural, folk, and religious beliefs that are more common among African Americans (AAs) have been associated with later-stage breast cancer. It is unknown if these beliefs are similarly associated with delays in diagnosis of ovarian cancer.

Methods: Data from a multicenter case-control study of ovarian cancer in AA women were used to examine associations between cultural/folk beliefs and religious practices and stage at diagnosis and symptom duration before diagnosis. Read More

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November 2018
1 Read

A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release.

Cell Discov 2018 20;4:62. Epub 2018 Nov 20.

Eureka Therapeutics, Inc, Emeryville, CA 94608 USA.

The clinical use of genetically modified T-cell therapies has led to unprecedented response rates in leukemia and lymphoma patients treated with anti-CD19 chimeric antigen receptor (CAR)-T. Despite this clinical success, FDA-approved T-cell therapies are currently limited to B-cell malignancies, and challenges remain with managing cytokine-related toxicities. We have designed a novel antibody-T-cell receptor (AbTCR) platform where we combined the Fab domain of an antibody with the γ and δ chains of the TCR as the effector domain. Read More

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November 2018
9 Reads

Cross-species evidence of interplay between neural connectivity at the micro- and macroscale of connectome organization in human, mouse and rat brain.

Brain Connect 2018 Nov 27. Epub 2018 Nov 27.

Vrije Universiteit Amsterdam, Faculty of Science, Center for Neurogenomics and cognitive research, complex traits genetics lab, Amsterdam, Netherlands ;

The mammalian brain describes a multi-scale system. At the microscale, axonal, dendritic and synaptic elements ensure neuron-to-neuron communication, and at the macroscale, large-scale projections form the anatomical wiring for communication between cortical areas. While it is clear that both levels of neural organization play a crucial role in brain functioning, their interaction is not extensively studied. Read More

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November 2018

Persistence and stochasticity are key determinants of genetic diversity in plants associated with banded iron formation inselbergs.

Biol Rev Camb Philos Soc 2018 Nov 26. Epub 2018 Nov 26.

Biodiversity and Conservation Science, Department of Biodiversity, Conservation and Attractions, Locked Bag 104, Bentley Delivery Centre, Perth, WA, 6983, Australia.

The high species endemism characteristic of many of the world's terrestrial island systems provides a model for studying evolutionary patterns and processes, yet there has been no synthesis of studies to provide a systematic evaluation of terrestrial island systems in this context. The banded iron formations (BIFs) of south-western Australia are ancient terrestrial island formations occurring within a mosaic of alluvial clay soils, sandplains and occasional granite outcropping, across an old, gently undulating, highly weathered, plateau. Notably, these BIFs display exceptionally high beta plant diversity. Read More

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November 2018

Long-term efficacy of laparoscopic Nissen versus Toupet fundoplication for the management of types III and IV hiatal hernias.

Surg Endosc 2018 Nov 26. Epub 2018 Nov 26.

Division of General Surgery, University of Kentucky, Lexington, KY, USA.

Background: Laparoscopic hiatal hernia repair via Toupet or Nissen fundoplication remains the most commonly performed procedures for management of large hiatal hernia. Few studies have compared the procedures' long-term effectiveness. This study sought to characterize the efficacy of laparoscopic Toupet versus Nissen fundoplication for types III and IV hiatal hernia. Read More

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November 2018
5 Reads

Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia.

Oncogene 2018 Nov 26. Epub 2018 Nov 26.

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

The poor outcomes in infant acute lymphoblastic leukemia (ALL) necessitate new treatments. Here we discover that EIF4E protein is elevated in most cases of infant ALL and test EIF4E targeting by the repurposed antiviral agent ribavirin, which has anticancer properties through EIF4E inhibition, as a potential treatment. We find that ribavirin treatment of actively dividing infant ALL cells on bone marrow stromal cells (BMSCs) at clinically achievable concentrations causes robust proliferation inhibition in proportion with EIF4E expression. Read More

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November 2018
7 Reads

Nurses need to be aware of their professional responsibilities when engaging with social media.

Authors:
David Barrett

Evid Based Nurs 2018 Nov 26. Epub 2018 Nov 26.

Faculty of Health Sciences, University of Hull, Hull, UK.

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November 2018

Short-term impact of PM on contemporaneous asthma medication use: Behavior and the value of pollution reductions.

Proc Natl Acad Sci U S A 2018 Nov 26. Epub 2018 Nov 26.

Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720.

Asthma ranks among the most costly of chronic diseases, accounting for over $50 billion annually in direct medical expenditures in the United States. At the same time, evidence has accumulated that fine particulate matter pollution can exacerbate asthma symptoms and generate substantial economic costs. To measure these costs, we use a unique nationwide panel dataset tracking asthmatic individuals' use of rescue medication and their exposure to PM (particulate matter with an aerodynamic diameter of <2. Read More

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November 2018

Safety and Efficacy of Intraoperative Computer-Navigated Versus Non-Navigated Shoulder Arthroplasty at a Tertiary Referral.

Orthop Clin North Am 2019 Jan 25;50(1):95-101. Epub 2018 Oct 25.

Department of Orthopedic Surgery, Stanford University, 450 Broadway Street, Redwood City, CA 94062, USA.

Emerging technologies in shoulder arthroplasty, such as 3-dimensional planning software and real-time intraoperative navigation, are now available for surgeons to perform more accurate placement of the glenoid component without malposition or perforation. Using these tools, the surgeon can visualize the version, inclination, and containment of the implant and determine whether augmented components would be necessary. This review provides an updated investigation of the present literature to elucidate the role of computer navigation in modern shoulder arthroplasty. Read More

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January 2019

Association Between Flat-Panel Computed Tomographic Imaging-Guided Place-Pitch Mapping and Speech and Pitch Perception in Cochlear Implant Users.

JAMA Otolaryngol Head Neck Surg 2018 Nov 21. Epub 2018 Nov 21.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of California, San Francisco.

Importance: Cochlear implant users generally display poor pitch perception. Flat-panel computed tomography (FPCT) has recently emerged as a modality capable of localizing individual electrode contacts within the cochlea in vivo. Significant place-pitch mismatch between the clinical implant processing settings given to patients and the theoretical maps based on FPCT imaging has previously been noted. Read More

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November 2018
1 Read

A low cost dural closure simulation model for tomorrow's spinal neurosurgeons.

Br J Neurosurg 2018 Nov 26:1-4. Epub 2018 Nov 26.

a Department of Neurosurgery , Institute of Neurological Sciences , Glasgow , UK.

Introduction: We present a low cost model that can be used to improve a trainee's skills in spinal dural closure. Development of microsurgical skills in a simulated environment provides a safe environment in which patients are protected. We argue that this is likely to improve the quality of dural closure, especially for surgeons early in their training and may lead to a commensurate reduction in post-operative CSF leak. Read More

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November 2018
6 Reads

How to…analyse qualitative data in different ways.

Clin Teach 2018 Nov 25. Epub 2018 Nov 25.

University of Groningen Medical Centre, Groningen, the Netherlands.

In this paper, the fifth in a series on qualitative research in medical education, we discuss approaches to analysing qualitative data. We focus primarily on analysing transcribed interview and focus group data. We also touch on the analysis of visual data, a potentially fruitful alternative approach. Read More

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November 2018

Cystic fibrosis is associated with an increased risk of Barrett's esophagus.

J Cyst Fibros 2018 Nov 22. Epub 2018 Nov 22.

Division of Digestive & Liver Diseases, Columbia University Medical Center, New York, NY, USA.

Background: Cystic fibrosis (CF) patients have increased risks of gastrointestinal cancers, including esophageal adenocarcinoma. Gastroesophageal reflux disease (GERD) is highly prevalent in CF and manifests at early ages. CF patients may be at increased risk for long-term sequelae of chronic GERD, including Barrett's esophagus (BE). Read More

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November 2018
1 Read

Physico-chemical stability of Plasma-Lyte 148 and Plasma-Lyte 148 + 5% Glucose with eight common intravenous medications.

Paediatr Anaesth 2018 Nov 25. Epub 2018 Nov 25.

School of Medicine, University of Nottingham, Nottingham, UK.

Background: Plasma-Lyte 148 is a balanced, crystalloid intravenous (IV) fluid which is both calcium-free and isotonic. It prevents the hyperchloraemic metabolic acidosis and iatrogenic hyponatraemia seen with use of 0.9% sodium chloride and hypotonic solutions respectively. Read More

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November 2018
1 Read

Testing a behavioral intervention to improve adherence to adjuvant endocrine therapy (AET).

Contemp Clin Trials 2018 Nov 22. Epub 2018 Nov 22.

Division of Medical Oncology, Duke University, Durham, NC, United States. Electronic address:

Adjuvant endocrine therapy (AET) is used to prevent recurrence and reduce mortality for women with hormone receptor positive breast cancer. Poor adherence to AET is a significant problem and contributes to increased medical costs and mortality. A variety of problematic symptoms associated with AET are related to non-adherence and early discontinuation of treatment. Read More

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November 2018
2 Reads

Impact of recreational and medicinal marijuana on surgical patients: A review.

Am J Surg 2018 Nov 14. Epub 2018 Nov 14.

Penn State Health St. Joseph's Medical Center, 2494 Bernville Road, Reading, PA, 19605, USA. Electronic address:

Background: As medicinal and recreational marijuana use broadens across the United States, knowledge of its effects on the body will become increasingly important to all health care providers, including surgeons.

Data Sources: We performed a literature review of Pubmed for articles discussing the basic science related to cannabinoids, as well as articles regarding cannabinoid medications, and cannabis use in surgical patients.

Conclusions: The primary components in the cannabis plant, tetrahydrocannabinol (THC) and cannabidiol (CBD), have been made available in numerous forms and formulations to treat multiple medical conditions, and recreational access to marijuana is increasing. Read More

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November 2018
1 Read

A controlled trial of HNSCC patient-derived xenografts reveals broad efficacy of PI3Kα inhibition in controlling tumor growth.

Int J Cancer 2018 Nov 23. Epub 2018 Nov 23.

Department of Otolaryngology - Head and Neck Surgery, Western University, London, Canada.

Head and neck squamous cell carcinomas (HNSCCs) frequently harbor alterations in the PI3K/AKT/mTOR signalling axis, particularly in the PIK3CA gene. PI3K-targeted agents have therefore gained considerable preclinical and clinical interest as emerging therapies for HNSCC. Identification of predictive biomarkers of response would advance the clinical application of PI3K-targeted drugs for patients in order to achieve maximal benefit. Read More

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November 2018
2 Reads

Diagnostic technologies and antimicrobial use in livestock systems.

Vet Rec 2018 Nov;183(20):626-627

Innogen Institute, University of Edinburgh, High School Yards, Edinburgh EH1 1LZ.

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November 2018

Efficacy of a topical formulation of selamectin plus sarolaner against induced infestations of Amblyomma americanum on cats and prevention of Cytauxzoon felis transmission.

Vet Parasitol 2018 Nov 11. Epub 2018 Nov 11.

Zoetis, Veterinary Medicine Research and Development, Kalamazoo, MI 49007, USA.

Cytauxzoonosis, caused by infection with Cytauxzoon felis, is the most severe tick-borne disease of cats. The purpose of our study was to determine the efficacy of selamectin (6.0 mg/kg) plus sarolaner (1. Read More

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November 2018

Why is a 3-year NRM following allogeneic transplantation still stuck at approximately 20%?

Authors:
John Barrett

Best Pract Res Clin Haematol 2018 Dec 21;31(4):414-419. Epub 2018 Sep 21.

Stem Cell Transplantation and Cellular Therapy Program, GW Cancer Center, George Washington University, Medical Faculty Associates, 2150 Pennsylvania Ave NW, Washington, DC 20037, USA. Electronic address:

Whether and when to recommend an allogeneic stem cell transplant (SCT) for a patient with leukemia is a treatment decision that rests on determining whether the transplant or non-transplant option carries the greatest probability of 3-5-year survival. While SCT confers a greater possibility of leukemia cure, the decision to transplant has to be made in the light of the high chance of treatment-related mortality (TRM) that follows the allograft. Here we identify that current estimates of a 20% 3-year TRM hold largely true for a variety of leukemias, diverse types of conditioning regimen, and varied donor-recipient compatibility across a wide age-range. Read More

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December 2018
5 Reads

Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS.

Anal Bioanal Chem 2018 Nov 21. Epub 2018 Nov 21.

Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

Angiotensinogen (AGT) is a critical protein in the renin-angiotensin-aldosterone system and may have an important role in the pathogenesis of pre-eclampsia. The disulphide linkage between cysteines 18 and 138 has a key role in the redox switch of AGT which modulates the release of angiotensin I with consequential effects on blood pressure. In this paper, we report a quantitative targeted LC-MS/MS method for the reliable measurement of the total AGT and its reduced and oxidised forms in human plasma. Read More

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November 2018
2 Reads

The evolution of bequeathal in stable habitats.

Ecol Evol 2018 Nov 16;8(21):10594-10607. Epub 2018 Oct 16.

Department of Anthropology University of California Davis California.

Adults sometimes disperse, while philopatric offspring inherit the natal site, a pattern known as . Despite a decades-old empirical literature, little theoretical work has explored when natural selection may favor bequeathal. We present a simple mathematical model of the evolution of bequeathal in a stable environment, under both global and local dispersal. Read More

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November 2018
2 Reads

Flight of an aeroplane with solid-state propulsion.

Nature 2018 Nov 21;563(7732):532-535. Epub 2018 Nov 21.

Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Cambridge, MA, USA.

Since the first aeroplane flight more than 100 years ago, aeroplanes have been propelled using moving surfaces such as propellers and turbines. Most have been powered by fossil-fuel combustion. Electroaerodynamics, in which electrical forces accelerate ions in a fluid, has been proposed as an alternative method of propelling aeroplanes-without moving parts, nearly silently and without combustion emissions. Read More

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November 2018
52 Reads

Health promotion.

Evid Based Nurs 2018 Nov 21. Epub 2018 Nov 21.

Faculty of Health Sciences, University of Hull, Hull, UK.

Read More

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November 2018
1 Read

Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma.

Sci Transl Med 2018 Nov;10(468)

Department of Immunology Discovery, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

Preclinical and clinical evidence indicates that a subset of asthma is driven by type 2 cytokines such as interleukin-4 (IL-4), IL-5, IL-9, and IL-13. Additional evidence predicts pathogenic roles for IL-6 and type I and type II interferons. Because each of these cytokines depends on Janus kinase 1 (JAK1) for signal transduction, and because many of the asthma-related effects of these cytokines manifest in the lung, we hypothesized that lung-restricted JAK1 inhibition may confer therapeutic benefit. Read More

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November 2018
3 Reads

Open Targets Platform: new developments and updates two years on.

Nucleic Acids Res 2018 Nov 20. Epub 2018 Nov 20.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.

The Open Targets Platform integrates evidence from genetics, genomics, transcriptomics, drugs, animal models and scientific literature to score and rank target-disease associations for drug target identification. The associations are displayed in an intuitive user interface (https://www.targetvalidation. Read More

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November 2018
4 Reads

Mosaics, mixtures, rotations or pyramiding: What is the optimal strategy to deploy major gene resistance?

Evol Appl 2018 Dec 17;11(10):1791-1810. Epub 2018 Sep 17.

CSIRO Agriculture and Food Canberra Australian Capital Territory Australia.

Once deployed uniformly in the field, genetically controlled plant resistance is often quickly overcome by pathogens, resulting in dramatic losses. Several strategies have been proposed to constrain the evolutionary potential of pathogens and thus increase resistance durability. These strategies can be classified into four categories, depending on whether resistance sources are varied across time (rotations) or combined in space in the same cultivar (pyramiding), in different cultivars within a field (cultivar mixtures) or among fields (mosaics). Read More

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December 2018
2 Reads

Terrestrial Bird Migration and West Nile Virus Circulation, United States.

Emerg Infect Dis 2018 Dec;24(12):2184-2194

Host migration and emerging pathogens are strongly associated, especially with regard to zoonotic diseases. West Nile virus (WNV), a mosquitoborne pathogen capable of causing severe, sometimes fatal, neuroinvasive disease in humans, is maintained in highly mobile avian hosts. Using phylogeographic approaches, we investigated the relationship between WNV circulation in the United States and the flight paths of terrestrial birds. Read More

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December 2018
2 Reads