1,115 results match your criteria Barrett's Esophagus Imaging

Highlighting the Undetectable - Fluorescence Molecular Imaging in Gastrointestinal Endoscopy.

Mol Imaging Biol 2022 Jun 28. Epub 2022 Jun 28.

Department of Medicine, Division of Gastroenterology, Stanford University School of Medicine, Stanford, CA, USA.

Flexible high-definition white-light endoscopy is the current gold standard in screening for cancer and its precursor lesions in the gastrointestinal tract. However, miss rates are high, especially in populations at high risk for developing gastrointestinal cancer (e.g. Read More

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Development of a Deep Learning Model for the Histological Diagnosis of Dysplasia in Barrett's Esophagus.

Gastrointest Endosc 2022 Jun 16. Epub 2022 Jun 16.

Barrett's Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Background And Aims: The risk of progression in Barrett's esophagus (BE) increases with development of dysplasia. There is a critical need to improve the diagnosis of BE dysplasia, given substantial interobserver disagreement among expert pathologists and overcalls of dysplasia by community pathologists. We developed a deep learning model to predict dysplasia grade on whole slide imaging. Read More

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Deciphering the Immune Complexity in Esophageal Adenocarcinoma and Pre-Cancerous Lesions With Sequential Multiplex Immunohistochemistry and Sparse Subspace Clustering Approach.

Front Immunol 2022 19;13:874255. Epub 2022 May 19.

Medical Research Council (MRC) Cancer Unit, Hutchison-Medical Research Council (MRC) Research Centre, University of Cambridge, Cambridge, United Kingdom.

Esophageal adenocarcinoma (EAC) develops from a chronic inflammatory environment across four stages: intestinal metaplasia, known as Barrett's esophagus, low- and high-grade dysplasia, and adenocarcinoma. Although the genomic characteristics of this progression have been well defined large-scale DNA sequencing, the dynamics of various immune cell subsets and their spatial interactions in their tumor microenvironment remain unclear. Here, we applied a sequential multiplex immunohistochemistry (mIHC) platform with computational image analysis pipelines that allow for the detection of 10 biomarkers in one formalin-fixed paraffin-embedded (FFPE) tissue section. Read More

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Validation of Novel Molecular Imaging Targets Identified by Functional Genomic mRNA Profiling to Detect Dysplasia in Barrett's Esophagus.

Cancers (Basel) 2022 May 17;14(10). Epub 2022 May 17.

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.

Barrett's esophagus (BE) is the precursor of esophageal adenocarcinoma (EAC). Dysplastic BE (DBE) has a higher progression risk to EAC compared to non-dysplastic BE (NDBE). However, the miss rates for the endoscopic detection of DBE remain high. Read More

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Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.

Endoscopy 2022 06 6;54(6):591-622. Epub 2022 May 6.

Department of Gastroenterology, Porto Comprehensive Cancer Center, and [email protected] (Health Research Network), Porto, Portugal.

ESGE recommends that the evaluation of superficial gastrointestinal (GI) lesions should be made by an experienced endoscopist, using high definition white-light and chromoendoscopy (virtual or dye-based).ESGE does not recommend routine performance of endoscopic ultrasonography (EUS), computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET)-CT prior to endoscopic resection.ESGE recommends endoscopic submucosal dissection (ESD) as the treatment of choice for most superficial esophageal squamous cell and superficial gastric lesions. Read More

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A new artificial intelligence system successfully detects and localises early neoplasia in Barrett's esophagus by using convolutional neural networks.

United European Gastroenterol J 2022 May 6. Epub 2022 May 6.

Division of Surgery and Interventional Sciences, University College London, London, UK.

Background And Aims: Seattle protocol biopsies for Barrett's Esophagus (BE) surveillance are labour intensive with low compliance. Dysplasia detection rates vary, leading to missed lesions. This can potentially be offset with computer aided detection. Read More

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Global variations in diagnostic guidelines for Barrett's esophagus.

Dig Endosc 2022 Apr 27. Epub 2022 Apr 27.

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

Endoscopic diagnosis of gastroesophageal junction and Barrett's esophagus is essential for surveillance and early detection of esophageal adenocarcinoma and esophagogastric junction cancer. Despite its small size, the gastroesophageal junction has many inherent problems, including marked differences in diagnostic methods for Barrett's esophagus in international guidelines. To define Barrett's esophagus, gastroesophageal junction location should be clarified. Read More

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[Endoscopic Interventional Treatment of Precancerous Lesions and Early Carcinoma of the Esophagus - Criteria and Techniques of Local Ablation and Resection].

Ther Umsch 2022 Apr;79(3-4):167-170

Klinik für Gastroenterologie, Hepatologie und Infektionskrankheiten, Universitätsklinikum Minden, Deutschland.

Endoscopic Interventional Treatment of Precancerous Lesions and Early Carcinoma of the Esophagus - Criteria and Techniques of Local Ablation and Resection Early carcinomas of the esophagus can safely be resected endoscopically and interventionally under very strict conditions (ER). In contrast to ablative procedures (radiofrequency ablation, cryo-ablation, argon plasma coagulation, photodynamic therapy), which can only be recommended for Barrett's or low-grade dysplasia, ER - which is called EMR (endoscopic mucosal resection in adenocarcinoma) or more in-depth ESD (endoscopic submucosa dissection in squamous cell carcinoma) - a defined, histologically examinable preparation. This is required starting with high-grade dysplasia, since 50% of patients with biopsy-confirmed high-grade dysplasia after ER already have an invasive carcinoma in the specimen. Read More

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Management of nondysplastic Barrett's esophagus: When to survey? When to ablate?

Ther Adv Chronic Dis 2022 12;13:20406223221086760. Epub 2022 Apr 12.

Center of Excellence for Barrett's Esophagus, Department of Gastroenterology/A30, Digestive Disease & Surgery Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195,USA.

Barrett's esophagus (BE), a precursor for esophageal adenocarcinoma (EAC), is defined as salmon-colored mucosa extending more than 1 cm proximal to the gastroesophageal junction with histological evidence of intestinal metaplasia. The actual risk of EAC in nondysplastic Barrett's esophagus (NDBE) is low with an annual incidence of 0.3%. Read More

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Advanced imaging and artificial intelligence for Barrett's esophagus: What we should and soon will do.

World J Gastroenterol 2022 Mar;28(11):1113-1122

Department of Endoscopy, Humanitas Research Hospital, IRCCS, Rozzano 20089, Italy.

Barrett's esophagus (BE) is a well-established risk factor for esophageal adenocarcinoma. It is recommended that patients have regular endoscopic surveillance, with the ultimate goal of detecting early-stage neoplastic lesions before they can progress to invasive carcinoma. Detection of both dysplasia or early adenocarcinoma permits curative endoscopic treatments, and with this aim, thorough endoscopic assessment is crucial and improves outcomes. Read More

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Agenesis of the Left Hepatic Lobe Accompanied by Esophagogastric Cancer: A Case Report and Literature Review.

Cureus 2022 Apr 8;14(4):e23960. Epub 2022 Apr 8.

Department of Upper Gastrointestinal Surgery, Juntendo University Hospital, Tokyo, JPN.

Agenesis of the left hepatic lobe is an exceedingly rare morphological anomaly. Moreover, agenesis of the left hepatic lobe accompanied by esophagogastric cancer is even rarer, with no reports to date. Agenesis of the hepatic lobe is commonly related to some anatomical variations of the gastrohepatic system. Read More

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Endoscopic findings of cardiac lymphoid hyperplasia and infection status.

DEN open 2022 Apr 22;2(1):e15. Epub 2021 Aug 22.

Second Department of Internal Medicine Shimane University Faculty of Medicine Shimane Japan.

Objective: Lymphoid hyperplasia is endoscopically observed as multiple small whitish round nodules or spots. This retrospective study was performed to examine the prevalence of that finding in patients with Barrett's epithelium and its relationship with the status of infection.

Methods: The study subjects were 3353 patients (males 2186, females 1167; mean age 55. Read More

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Diagnostic performance of volumetric laser endomicroscopy for Barrett's esophagus dysplasia amongst gastroenterology trainees.

Transl Gastroenterol Hepatol 2022 25;7. Epub 2022 Jan 25.

Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Background: Volumetric laser endomicroscopy (VLE) is an advanced imaging modality used in Barrett's esophagus (BE) surveillance. VLE image interpretation is challenged by subtle grayscale image variation across a large amount of data. Training in VLE interpretation is not standardized. Read More

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January 2022

Unsedated Transnasal Endoscopy: A Safe, Well-Tolerated and Accurate Alternative to Standard Diagnostic Peroral Endoscopy.

Dig Dis Sci 2022 Jun 3;67(6):1937-1947. Epub 2022 Mar 3.

The Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, UK.

Diagnostic unsedated transnasal endoscopy (uTNE) has been proven to be a safe and well-tolerated procedure. Although its utilization in the United Kingdom (UK) is increasing, it is currently available in only a few centers. Through consideration of recent studies, we aimed to perform an updated review of the technological advances in uTNE, consider their impact on diagnostic accuracy, and to determine the role of uTNE in the COVID-19 era. Read More

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Image-Enhanced Endoscopy and Molecular Biomarkers Vs Seattle Protocol to Diagnose Dysplasia in Barrett's Esophagus.

Clin Gastroenterol Hepatol 2022 Feb 17. Epub 2022 Feb 17.

Medical Research Council Cancer Unit, University of Cambridge, United Kingdom; Department of Gastroenterology, University Hospital National Health Service Foundation Trust, United Kingdom. Electronic address:

Background & Aims: Dysplasia in Barrett's esophagus often is invisible on high-resolution white-light endoscopy (HRWLE). We compared the diagnostic accuracy for inconspicuous dysplasia of the combination of autofluorescence imaging (AFI)-guided probe-based confocal laser endomicroscopy (pCLE) and molecular biomarkers vs HRWLE with Seattle protocol biopsies.

Methods: Barrett's esophagus patients with no dysplastic lesions were block-randomized to standard endoscopy (HRWLE with the Seattle protocol) or AFI-guided pCLE with targeted biopsies for molecular biomarkers (p53 and cyclin A by immunohistochemistry; aneuploidy by image cytometry), with crossover to the other arm after 6 to 12 weeks. Read More

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February 2022

Esophageal OCT Imaging Using a Paddle Probe Externally Attached to Endoscope.

Dig Dis Sci 2022 Jan 27. Epub 2022 Jan 27.

Department of Biomedical Engineering, Duke University, Durham, NC, USA.

Background And Aims: Endoscopic surveillance of Barrett's esophagus (BE) by white light examination is insufficient to diagnose dysplastic change. In this work, we describe an optical imaging method to obtain high-resolution cross-sectional imaging using a paddle-shaped probe affixed to the endoscope tip.

Methods: We integrated Optical Coherence Tomography (OCT), an optical imaging method that produces cross-sectional images, into a paddle probe attached to video endoscope. Read More

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January 2022

Prediction of neoplastic progression in Barrett's esophagus using nanoscale nuclear architecture mapping: a pilot study.

Gastrointest Endosc 2022 Jun 20;95(6):1239-1246. Epub 2022 Jan 20.

Department of Pathology, Cleveland Clinic, Cleveland, Ohio, USA.

Background And Aims: Nanoscale nuclear architecture mapping (nanoNAM), an optical coherence tomography-derived approach, is capable of detecting with nanoscale sensitivity structural alterations in the chromatin of epithelial cell nuclei at risk for malignant transformation. Because these alterations predate the development of dysplasia, we aimed to use nanoNAM to identify patients with Barrett's esophagus (BE) who might progress to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC).

Methods: This is a nested case-control study of 46 BE patients, of which 21 progressed to HGD/EAC over 3. Read More

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Use of a Cytosponge biomarker panel to prioritise endoscopic Barrett's oesophagus surveillance: a cross-sectional study followed by a real-world prospective pilot.

Lancet Oncol 2022 02 11;23(2):270-278. Epub 2022 Jan 11.

MRC Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Cambridge, UK. Electronic address:

Background: Endoscopic surveillance is recommended for patients with Barrett's oesophagus because, although the progression risk is low, endoscopic intervention is highly effective for high-grade dysplasia and cancer. However, repeated endoscopy has associated harms and access has been limited during the COVID-19 pandemic. We aimed to evaluate the role of a non-endoscopic device (Cytosponge) coupled with laboratory biomarkers and clinical factors to prioritise endoscopy for Barrett's oesophagus. Read More

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February 2022

CXCR4 peptide-based fluorescence endoscopy in a mouse model of Barrett's esophagus.

EJNMMI Res 2022 Jan 10;12(1). Epub 2022 Jan 10.

II Medizinische Klinik, Klinikum rechts der isar, Technische Universität München, Munich, Germany.

Background: Near-infrared (NIR) fluorescence imaging has been emerging as a promising strategy to overcome the high number of early esophageal adenocarcinomas missed by white light endoscopy and random biopsy collection. We performed a preclinical assessment of fluorescence imaging and endoscopy using a novel CXCR4-targeted fluorescent peptide ligand in the L2-IL1B mouse model of Barrett's esophagus.

Methods: Six L2-IL1B mice with advanced stage of disease (12-16 months old) were injected with the CXCR4-targeted, Sulfo-Cy5-labeled peptide (MK007), and ex vivo wide-field imaging of the whole stomach was performed 4 h after injection. Read More

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January 2022

Patients With Adenocarcinoma of the Esophagus or Esophagogastric Junction Frequently Have Potential Screening Opportunities.

Gastroenterology 2022 04 20;162(4):1349-1351.e5. Epub 2021 Dec 20.

Veterans Affairs Center for Clinical Management Research, LTC Charles S. Kettles Veterans Affairs Medical Center, Ann Arbor, Michigan; Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan; Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan.

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Identification of Barrett's esophagus in endoscopic images using deep learning.

BMC Gastroenterol 2021 Dec 17;21(1):479. Epub 2021 Dec 17.

School of Computer Science and Engineering, University of Electronic Science and Technology of China, 4 North Jianshe Road, Chengdu, 610054, Sichuan, China.

Background: Development of a deep learning method to identify Barrett's esophagus (BE) scopes in endoscopic images.

Methods: 443 endoscopic images from 187 patients of BE were included in this study. The gastroesophageal junction (GEJ) and squamous-columnar junction (SCJ) of BE were manually annotated in endoscopic images by experts. Read More

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December 2021

Advanced Endoscopic Imaging and Interventions in GERD: An Update and Future Directions.

Front Med (Lausanne) 2021 29;8:728696. Epub 2021 Nov 29.

Division of Gastroenterology, Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, United States.

Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal diseases encountered in primary care and gastroenterology clinics. Most cases of GERD can be diagnosed based on clinical presentation and risk factors; however, some patients present with atypical symptoms, which can make diagnosis difficult. An esophagogastroduodenoscopy can be used to assist in diagnosis of GERD, though only half of these patients have visible endoscopic findings on standard white light endoscopy. Read More

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November 2021

Artificial Intelligence and Deep Learning for Upper Gastrointestinal Neoplasia.

Gastroenterology 2022 04 11;162(4):1056-1066. Epub 2021 Dec 11.

Humanitas University, Department of Biomedical Sciences, Pieve Emanuele, Italy; Humanitas Clinical and Research Center-IRCCS, Endoscopy Unit, Rozzano, Italy. Electronic address:

Upper gastrointestinal (GI) neoplasia account for 35% of GI cancers and 1.5 million cancer-related deaths every year. Despite its efficacy in preventing cancer mortality, diagnostic upper GI endoscopy is affected by a substantial miss rate of neoplastic lesions due to failure to recognize a visible lesion or imperfect navigation. Read More

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Targeted Hsp70 fluorescence molecular endoscopy detects dysplasia in Barrett's esophagus.

Eur J Nucl Med Mol Imaging 2022 05 9;49(6):2049-2063. Epub 2021 Dec 9.

II Medizinische Klinik, Klinikum Rechts Der Isar, Technische Universität München, Munich, Germany.

Purpose: The incidence of esophageal adenocarcinoma (EAC) has been increasing for decades without significant improvements in treatment. Barrett's esophagus (BE) is best established risk factor for EAC, but current surveillance with random biopsies cannot predict progression to cancer in most BE patients due to the low sensitivity and specificity of high-definition white light endoscopy.

Methods: Here, we evaluated the membrane-bound highly specific Hsp70-specific contrast agent Tumor-Penetrating Peptide (Hsp70-TPP) in guided fluorescence molecular endoscopy biopsy. Read More

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Clinicopathologic correlations of superficial esophageal adenocarcinoma in endoscopic submucosal dissection specimens.

Diagn Pathol 2021 Nov 27;16(1):111. Epub 2021 Nov 27.

Division of Gastroenterology, Baylor College of Medicine, Margaret M. and Albert B. Alkek Department of Medicine, McNair Campus 7200 Cambridge Street 8th Floor, Houston, TX, 77030, USA.

Background: Endoscopic submucosal dissection (ESD) is a novel endoscopic treatment for early esophageal adenocarcinoma (EAC). The western pathologists' experience with ESD specimens remains limited. This study aimed to correlate histopathologic features of Barrett's esophagus (BE)-associated adenocarcinoma in ESD resections with clinical outcomes to determine whether they aid future management decisions. Read More

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November 2021

Artificial intelligence in gastroenterology: A state-of-the-art review.

World J Gastroenterol 2021 Oct;27(40):6794-6824

Section of Health Services Research, Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX 77030, United States.

The development of artificial intelligence (AI) has increased dramatically in the last 20 years, with clinical applications progressively being explored for most of the medical specialties. The field of gastroenterology and hepatology, substantially reliant on vast amounts of imaging studies, is not an exception. The clinical applications of AI systems in this field include the identification of premalignant or malignant lesions (, identification of dysplasia or esophageal adenocarcinoma in Barrett's esophagus, pancreatic malignancies), detection of lesions (, polyp identification and classification, small-bowel bleeding lesion on capsule endoscopy, pancreatic cystic lesions), development of objective scoring systems for risk stratification, predicting disease prognosis or treatment response [, determining survival in patients post-resection of hepatocellular carcinoma), determining which patients with inflammatory bowel disease (IBD) will benefit from biologic therapy], or evaluation of metrics such as bowel preparation score or quality of endoscopic examination. Read More

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October 2021

Is There an Increasing Incidence of Gastroesophageal Junctional Adenocarcinoma and Barrett Esophagus in Asia? A Review of Diagnostic Conundrums.

Digestion 2022 15;103(1):37-44. Epub 2021 Nov 15.

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

Background: Epidemiology data of gastroesophageal junction (GEJ) cancers in Asia are extremely scarce. It is hardly registered by any cancer registry in the region, and only a few reports are available. Based on existing literature works, the overall trend indicates similar or gradually increasing GEJ cancers in Asia but comparably less than the West. Read More

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January 2022

Whole circumferential endoscopic submucosal dissection of superficial adenocarcinoma in long-segment Barrett's esophagus: A case report.

World J Gastrointest Surg 2021 Oct;13(10):1285-1292

Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan.

Background: Esophageal adenocarcinoma (EAC) derived from long-segment Barrett's esophagus (LSBE) is extremely rare in Asia. LSBE-related EAC is often difficult to diagnose in the horizontal extent. If the tumor has spread throughout the LSBE, whole circumferential endoscopic submucosal dissection (ESD) should be performed, which is difficult to complete safely. Read More

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October 2021

Linked-color Imaging May Help Improve the Visibility of Superficial Barrett's Esophageal Adenocarcinoma by Increasing the Color Difference.

Intern Med 2021 1;60(21):3351-3358. Epub 2021 Nov 1.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.

Objective Linked-color imaging (LCI), a new technology for image-enhanced endoscopy, emphasizes the color of the mucosa, and its practicality in the detection of early gastric and colon cancers has been reported. However, whether or not LCI is useful for the diagnosis of Barrett's adenocarcinoma (BA) has been unclear. In this study, we explored whether or not LCI enhances the color difference between a BA lesion and the surrounding mucosa. Read More

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November 2021