898 results match your criteria Barrett's Esophagus Imaging


Narrow-Band Imaging: Clinical Application in Gastrointestinal Endoscopy.

GE Port J Gastroenterol 2018 Dec 27;26(1):40-53. Epub 2018 Mar 27.

Department of Gastroenterology, Instituto Português de Oncologia do Porto, Porto, Portugal.

Narrow-band imaging is an advanced imaging system that applies optic digital methods to enhance endoscopic images and improves visualization of the mucosal surface architecture and microvascular pattern. Narrow-band imaging use has been suggested to be an important adjunctive tool to white-light endoscopy to improve the detection of lesions in the digestive tract. Importantly, it also allows the distinction between benign and malignant lesions, targeting biopsies, prediction of the risk of invasive cancer, delimitation of resection margins, and identification of residual neoplasia in a scar. Read More

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https://www.karger.com/Article/FullText/487470
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http://dx.doi.org/10.1159/000487470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341367PMC
December 2018
6 Reads

5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas.

J Neurooncol 2019 Feb 18;141(3):595-607. Epub 2019 Jan 18.

Brain Tumor Nanotechnology Laboratory, Department of Neurosurgery, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Introduction: Photodynamic therapy (PDT) is a two-step treatment involving the administration of a photosensitive agent followed by its activation at a specific light wavelength for targeting of tumor cells.

Materials/methods: A comprehensive review of the literature was performed to analyze the indications for PDT, mechanisms of action, use of different photosensitizers, the immunomodulatory effects of PDT, and both preclinical and clinical studies for use in high-grade gliomas (HGGs).

Results: PDT has been approved by the United States Food and Drug Administration (FDA) for the treatment of premalignant and malignant diseases, such as actinic keratoses, Barrett's esophagus, esophageal cancers, and endobronchial non-small cell lung cancers, as well as for the treatment of choroidal neovascularization. Read More

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http://dx.doi.org/10.1007/s11060-019-03103-4DOI Listing
February 2019
1 Read

Measuring Barrett's Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment.

Dig Dis Sci 2019 Jan 10. Epub 2019 Jan 10.

Department of Pathology & Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA.

Background: Radiofrequency ablation (RFA) treatment outcomes vary for unknown reasons. One hypothesis is that variations in Barrett's epithelial thickness (BET) are associated with reduced RFA efficacy for thicker BET and strictures for thinner BET. Volumetric laser endomicroscopy (VLE) is an imaging modality that acquires high-resolution, depth-resolved images of BE. Read More

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http://dx.doi.org/10.1007/s10620-018-5453-1DOI Listing
January 2019
4 Reads

Feasibility of a simplified narrow-band imaging classification system for Barrett's esophagus for novice endoscopists.

J Gastroenterol 2019 Jan 2. Epub 2019 Jan 2.

National Hospital Organization Hakodate Hospital, Hakodate, Japan.

Background: Narrow-band imaging (NBI) classifications for Barrett's esophagus have been proposed for the detection of early esophageal adenocarcinoma. We developed a simplified classification system with demonstrated high diagnostic accuracy and reproducibility among experienced endoscopists, but the feasibility of this system among novice endoscopists was unclear.

Methods: In the present study, eight novice endoscopists with no experience of magnification endoscopy were asked to review 248 images of Barrett's esophagus (72 dysplastic, 176 non-dysplastic) obtained using high-definition magnification endoscopy with NBI 6 weeks before (1st test), immediately after (2nd test), and 6 weeks after (3rd test) being taught the simplified classification system. Read More

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http://dx.doi.org/10.1007/s00535-018-01537-7DOI Listing
January 2019
10 Reads

Artificial intelligence and upper gastrointestinal endoscopy: current status and future perspective.

Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.

Graduate School of Informatics, Nagoya University, Nagoya, Japan.

With recent breakthroughs in artificial intelligence, computer-aided diagnosis (CAD) for upper gastrointestinal endoscopy is gaining increasing attention. Main research focuses in this field include automated identification of dysplasia in Barrett's esophagus and detection of early gastric cancers. By helping endoscopists avoid missing and mischaracterizing neoplastic change in both the esophagus and stomach, these technologies potentially contribute to solving current limitations of gastroscopy. Read More

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http://dx.doi.org/10.1111/den.13317DOI Listing
December 2018
3 Reads

Benefits of the Seattle biopsy protocol in the diagnosis of Barrett's esophagus in a Chinese population.

World J Clin Cases 2018 Nov;6(14):753-758

Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.

Aim: To investigate the benefits of the Seattle protocol in the diagnosis of Chinese individuals with Barrett's esophagus.

Methods: Subjects enrolled were patients from one center with endoscopically-suspected esophageal metaplasia. These patients first received narrow-band imaging-targeted biopsy, and later, the Seattle protocol-guided biopsy, within a period from October 2012 to December 2014. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i14.753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264992PMC
November 2018
1 Read

Cryotherapy in the management of premalignant and malignant conditions of the esophagus.

World J Gastroenterol 2018 Nov;24(43):4862-4869

Department of Gastroenterology, Digestive Disease Surgery Institute, Cleveland Clinic, Cleveland, OH 44195, United States.

Endoscopic cryotherapy is a relatively new thermal ablative modality used for the treatment of neoplastic lesions of the esophagus. It relies on cycles of rapid cooling and thawing to induce tissue destruction with a cryogen (liquid nitrogen or carbon dioxide) leading to intra and extra-cellular damage. Surgical treatment was once considered the standard therapeutic intervention for neoplastic diseases of the esophagus and is associated with considerable rates of morbidity and mortality. Read More

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http://dx.doi.org/10.3748/wjg.v24.i43.4862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250921PMC
November 2018
10 Reads

Blue-light imaging has an additional value to white-light endoscopy in visualization of early Barrett's neoplasia: an international multicenter cohort study.

Gastrointest Endosc 2018 Nov 9. Epub 2018 Nov 9.

Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Background And Aims: Endoscopic features of early neoplasia in Barrett's esophagus (BE) are subtle. Blue-light imaging (BLI) may improve visualization of neoplastic lesions. The aim of this study was to evaluate BLI in visualization of Barrett's neoplasia. Read More

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http://dx.doi.org/10.1016/j.gie.2018.10.046DOI Listing
November 2018

Precision care for Barrett's esophagus.

Transl Gastroenterol Hepatol 2018 17;3:67. Epub 2018 Sep 17.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.

Modern recognition and management of Barrett's esophagus, a precursor to esophageal adenocarcinoma depends on diagnostic accuracy, risk assessment, technical expertise and consideration of many options to best tailor therapy for every patient. Concomitant management of acid reflux is essential, frequently with proton pump inhibitors. Ablation and resection favorably affect the evolution towards cancer. Read More

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http://dx.doi.org/10.21037/tgh.2018.09.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182039PMC
September 2018
11 Reads

2017 David Sun Lecture: Screening and Surveillance of Barrett's Esophagus: Where Are We Now and What Does the Future Hold?

Authors:
Gary W Falk

Am J Gastroenterol 2019 Jan;114(1):64-70

Division of Gastroenterology, Department of Medicine Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Barrett's esophagus and esophageal adenocarcinoma continue to present considerable management challenges in the Western world. Despite our best efforts to date, the prognosis of advanced esophageal adenocarcinoma remains poor and far too many individuals with esophageal adenocarcinoma have not had a prior endoscopy to detect Barrett's esophagus. As such, current strategies of screening for Barrett's esophagus and subsequent surveillance need to be further optimized. Read More

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http://dx.doi.org/10.1038/s41395-018-0374-3DOI Listing
January 2019
2 Reads

Barrett's esophagus with high grade dysplasia is associated with non-esophageal cancer.

World J Gastroenterol 2018 Oct;24(39):4472-4481

Department of Gastroenterology, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.

Aim: To study factors associated with esophageal and non-esophageal cancer morbidity among Barrett's esophagus (BE) patients.

Methods: A cohort study within a single tertiary center included 386 consecutive patients with biopsy proven BE, who were recruited between 2004-2014. Endoscopic and histologic data were prospectively recorded. Read More

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http://dx.doi.org/10.3748/wjg.v24.i39.4472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196339PMC
October 2018
11 Reads

Outcome of endoscopic mucosal resection in Barrett's esophagus determined by systematic quantification of epithelial glands using volumetric laser endomicroscopy.

Gastrointest Endosc 2018 Oct 16. Epub 2018 Oct 16.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

Background: Dysplastic Barrett's esophagus (BE) lesions ≤2 cm in size can be targeted for en-bloc endoscopic mucosal resection (EMR). White-light endoscopy can underestimate the size of a lesion, limiting complete resection. Volumetric laser endomicroscopy (VLE) provides high-resolution cross-sectional imaging of BE. Read More

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http://dx.doi.org/10.1016/j.gie.2018.09.038DOI Listing
October 2018
1 Read

[The acid pocket - a novel target for the treatment of gastro-esophageal reflux disease].

Z Gastroenterol 2018 Oct 10;56(10):1276-1282. Epub 2018 Oct 10.

Bauchzentrum, Abteilung für Gastroenterologie, St. Claraspital, Basel, Schweiz.

Increased acid reflux after meals is a key feature of gastro-esophageal reflux disease (GERD) and is the most important cause for patient symptoms, particularly heartburn and acid regurgitation. Chronic acid exposure also predisposes to associated pathologies including reflux esophagitis, esophageal stricture, Barrett's esophagus, and Barrett's carcinoma (esophageal adenocarcinoma). The severity of esophageal symptoms and mucosal damage is related to two key factors, (i) the acidity of the refluxate, which depends primarily on the gastric secretory output and its distribution within the stomach, and (ii) the frequency and duration of reflux events which depends on the efficacy of the reflux barrier at the gastro-esophageal junction and the esophageal clearance function. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0645-7169
Publisher Site
http://dx.doi.org/10.1055/a-0645-7169DOI Listing
October 2018
3 Reads

Advanced Imaging for Barrett's Esophagus and Early Neoplasia: Surface and Subsurface Imaging for Diagnosis and Management.

Curr Gastroenterol Rep 2018 Oct 9;20(12):54. Epub 2018 Oct 9.

VA Boston Healthcare, Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA, 02132, USA.

Purpose Of Review: Esophageal adenocarcinoma bears one of the fastest rising incidence of any cancers and generally arises in the setting of gastroesophageal reflux and Barrett's esophagus. However, early detection of neoplasia can be challenging since most patients are asymptomatic until they progress to more advanced and less curable stages, and early dysplastic lesions can be small, multifocal, and difficult to detect. Clearly, new imaging tools are needed in light of sampling error associated with random biopsies, the current standard of practice. Read More

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http://dx.doi.org/10.1007/s11894-018-0661-6DOI Listing
October 2018
14 Reads

Virtual chromoendoscopy by using optical enhancement improves the detection of Barrett's esophagus-associated neoplasia.

Gastrointest Endosc 2019 02 3;89(2):247-256.e4. Epub 2018 Oct 3.

Division of Surgery and Interventional Science, University College London, London; Department of Gastroenterology, University College Hospital NHS Foundation Trust, London.

Background And Aims: The Seattle protocol for endoscopic Barrett's esophagus (BE) surveillance samples a small portion of the mucosal surface area, risking a potentially high miss rate of early neoplastic lesions. We assessed whether the new iScan Optical Enhancement system (OE) improves the detection of early BE-associated neoplasia compared with high-definition white-light endoscopy (HD-WLE) in both expert and trainee endoscopists to target sampling of suspicious areas. Such a system may both improve early neoplasia detection and reduce the need for random biopsies. Read More

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http://dx.doi.org/10.1016/j.gie.2018.09.032DOI Listing
February 2019
2 Reads

Enhancing the Detection of Barrett Esophagus.

Thorac Surg Clin 2018 Nov;28(4):453-464

Esophageal and Lung Institute, Allegheny Health Network, Western Pennsylvania Hospital, Suite 158, Mellon Pavilion, 4815 Liberty Avenue, Pittsburgh, PA 15224, USA. Electronic address:

In Western countries, the incidence of esophageal adenocarcinoma has increased rapidly in parallel with its premalignant condition, Barrett esophagus (BE). Unlike colonoscopy, endoscopic screening for BE is not currently recommended for all patients; however, surveillance endoscopy is advocated for patients with established BE. Novel imaging and sampling techniques have been developed and investigated for the purpose of improving the detection of Barrett esophagus, dysplasia, and neoplasia. Read More

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http://dx.doi.org/10.1016/j.thorsurg.2018.07.011DOI Listing
November 2018
7 Reads

A prospective multicenter study using a new multiband mucosectomy device for endoscopic resection of early neoplasia in Barrett's esophagus.

Gastrointest Endosc 2018 10 6;88(4):647-654. Epub 2018 Jul 6.

Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Background And Aims: Early neoplasia in Barrett's esophagus (BE) can be effectively and safely removed by endoscopic resection (ER) using multiband mucosectomy (MBM). This study aimed to document performance of a novel MBM device designed for improved visualization, easier passage of accessories, and better suction power compared with other marketed MBM devices.

Methods: This international, single-arm, prospective registry in 14 referral centers (Europe, 10; United States, 3; Canada, 1) included patients with early BE neoplasia scheduled for ER. Read More

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http://dx.doi.org/10.1016/j.gie.2018.06.030DOI Listing
October 2018
1 Read

Management of oesophageal intramucosal carcinoma.

BMJ Case Rep 2018 Sep 14;2018. Epub 2018 Sep 14.

Sunnybank Obesity Centre and South East Queensland Surgery, Brisbane, Queensland, Australia.

We present an interesting case of an intramucosal carcinoma (IMC) in the setting of Barrett's oesophagus in a 66-year-old woman. Her clinical course highlights the shifting paradigm in the approach to management of Barrett's oesophagus and IMC. With innovation in imaging and endoscopic treatment modalities, patients are detected earlier and managed prior to development of malignancy. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22489
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http://dx.doi.org/10.1136/bcr-2018-224893DOI Listing
September 2018
16 Reads

Real-time diagnosis of Barrett's esophagus: a prospective, multicenter study comparing confocal laser endomicroscopy with conventional histology for the identification of intestinal metaplasia in new users.

Surg Endosc 2018 Sep 10. Epub 2018 Sep 10.

Minnesota Institute for Minimally Invasive Surgery, Crosby, MN, USA.

Introduction: Endoscopic evaluation with high-definition white light endoscopy and random 4-quadrant biopsy (Seattle Protocol) is the current standard of care for the detection of Barrett's esophagus (BE). Recently, enhanced imaging technologies have become available to provide real-time diagnosis of intestinal metaplasia (IM) and dysplasia, reducing the need for tissue biopsy. Probe-based confocal laser endomicroscopy (pCLE) provides dynamic microscopic mucosal views, rapidly capturing digital images that become optical biopsies. Read More

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http://dx.doi.org/10.1007/s00464-018-6420-9DOI Listing
September 2018
1 Read

A Survey of Expert Practice and Attitudes Regarding Advanced Imaging Modalities in Surveillance of Barrett's Esophagus.

Dig Dis Sci 2018 12 3;63(12):3262-3271. Epub 2018 Sep 3.

University of Colorado Anschutz Medical Center, Mail Stop F735, 1635 Aurora Court, Rm 2.031, Aurora, CO, 80045, USA.

Background: Published guidelines do not address what the minimum incremental diagnostic yield (IDY) for detection of dysplasia/cancer is required over the standard Seattle protocol for an advanced imaging modality (AIM) to be implemented in routine surveillance of Barrett's esophagus (BE) patients. We aimed to report expert practice patterns and attitudes, specifically addressing the minimum IDY in the use of AIMs in BE surveillance.

Methods: An international group of BE experts completed an anonymous electronic survey of domains relevant to surveillance practice patterns and use of AIMs. Read More

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http://dx.doi.org/10.1007/s10620-018-5257-3DOI Listing
December 2018
2 Reads

Modeling Wnt signaling by CRISPR-Cas9 genome editing recapitulates neoplasia in human Barrett epithelial organoids.

Cancer Lett 2018 Nov 23;436:109-118. Epub 2018 Aug 23.

Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA; Division of Gastroenterology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA. Electronic address:

Primary organoid cultures generated from patient biopsies comprise a novel improved platform for disease modeling, being genetically stable and closely recapitulating in vivo scenarios. Barrett esophagus (BE) is the major risk factor for esophageal adenocarcinoma. There has been a dearth of long-term in vitro expansion models of BE neoplastic transformation. Read More

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http://dx.doi.org/10.1016/j.canlet.2018.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152930PMC
November 2018
7 Reads

PillCamColon2 after incomplete colonoscopy - A prospective multicenter study.

World J Gastroenterol 2018 Aug;24(31):3556-3566

Clinic for Internal Medicine, Bethesda Krankenhaus Bergedorf, Hamburg 21029, Germany.

Aim: To evaluate the ability of PillCamColon2 to visualize colonic segments missed by incomplete optical colonoscopy (OC) and to assess the diagnostic yield.

Methods: This prospective multicentre study included 81 patients from nine centres who underwent second-generation colon capsule endoscopy (CCE) following incomplete OC performed by an experienced gastroenterologist (> 1000 colonoscopies). Patients with stenosis were excluded. Read More

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http://dx.doi.org/10.3748/wjg.v24.i31.3556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102503PMC
August 2018
13 Reads

Acceptability, Accuracy, and Safety of Disposable Transnasal Capsule Endoscopy for Barrett's Esophagus Screening.

Clin Gastroenterol Hepatol 2018 Aug 3. Epub 2018 Aug 3.

National Institute for Health Research Biomedical Research Center in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and the University of Nottingham, Queens Medical Center Campus, Nottingham, United Kingdom; Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Queens Medical Centre Campus, Nottingham, United Kingdom. Electronic address:

Background & Aims: Screening for Barrett's esophagus (BE) with conventional esophagogastroduodenoscopy (C-EGD) is expensive. We assessed the performance of a clinic-based, single use transnasal capsule endoscope (EG Scan II) for the detection of BE, compared to C-EGD as the reference standard.

Methods: We performed a prospective multicenter cohort study of patients with and without BE recruited from 3 referral centers (1 in the United States and 2 in the United Kingdom). Read More

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http://dx.doi.org/10.1016/j.cgh.2018.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330075PMC
August 2018
22 Reads
7.900 Impact Factor

Tethered capsule endomicroscopy for microscopic imaging of the esophagus, stomach, and duodenum without sedation in humans (with video).

Gastrointest Endosc 2018 11 19;88(5):830-840.e3. Epub 2018 Jul 19.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard-MIT Division of Health Sciences Technology, Cambridge, Massachusetts, USA.

Background And Aims: Patients with many different digestive diseases undergo repeated EGDs throughout their lives. Tethered capsule endomicroscopy (TCE) is a less-invasive method for obtaining high-resolution images of the GI mucosa for diagnosis and treatment planning of GI tract diseases. In this article, we present our results from a single-center study aimed at testing the safety and feasibility of TCE for imaging the esophagus, stomach, and duodenum. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165107183285
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http://dx.doi.org/10.1016/j.gie.2018.07.009DOI Listing
November 2018
21 Reads

Development of benchmark quality criteria for assessing whole-endoscopy Barrett's esophagus biopsy cases.

United European Gastroenterol J 2018 Jul 7;6(6):830-837. Epub 2018 Mar 7.

Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands.

Background: Dysplasia in Barrett's esophagus (BE) biopsies is associated with low observer agreement among general pathologists. Therefore, expert review is advised. We are developing a web-based, national expert review panel for histological review of BE biopsies. Read More

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http://dx.doi.org/10.1177/2050640618764710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047285PMC
July 2018
2 Reads

Barrett's esophagus and gland cancer - the experience of one center.

Pol Przegl Chir 2018 May;90(3):19-24

Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun.

Objective: The aim of the study was to evaluate the prevalence and clinical aspects of Barrett's esophagus and adenocarcinoma of the lower part of esophagus in gastroscopy.

Material And Methods: Retrospective review of 10000 upper gastrointestinal endoscopic examinations were performed at the Department of Oncology Endoscopy in Bydgoszcz from 2004 to 2014 in terms of incidence of Barrett's esophagus and adenocarcinoma in the lower part of esophagus.

Results: The medical records of 5378 (53. Read More

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http://dx.doi.org/10.5604/01.3001.0011.8166DOI Listing
May 2018
15 Reads

Molecular imaging in gastroenterology: A route for personalized endoscopy.

Dig Liver Dis 2018 Sep 23;50(9):878-885. Epub 2018 Jun 23.

Department of Medicine I, Division of Gastroenterology, Ludwig Demling Endoscopy Center of Excellence, University Hospital of Erlangen, Germany. Electronic address:

With the rapid expansion and diversification of the repertoire of biological agents utilized in inflammatory bowel diseases and cancer and the increase in oncological patients in gastroenterology, visualization of single receptor or molecular target expression and the subsequent initiation of expression tailored therapy are gaining increasing attention. Through the combination of utilizing fluorescently labeled probes with high specificity towards defined molecular targets and their subsequent detection and visualization with endoscopic devices, molecular imaging is a new emerging field focusing on the receptor expression within the mucosa on a cellular level rather than on macroscopic changes. In the past years various new technological and molecular probes have been successfully utilized for molecular imaging. Read More

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http://dx.doi.org/10.1016/j.dld.2018.06.009DOI Listing
September 2018
7 Reads

Barrett's Esophagus in Patients with Gastroesophageal Reflux Disease.

J Nepal Health Res Counc 2018 Jul 3;16(2):144-148. Epub 2018 Jul 3.

Department of Gastroenterology, College of Medical Sciences Teaching Hospital, Bharatpur, Chitwan, Nepal.

Background: Barrett's esophagus a is metaplasia of normal squamous cells that line the lower part of the esophagus and carries a major risk for adenocarcinoma of esophagus. In Asian population, the prevalence of Barrett's esophagus and adenocarcinoma are less common than in Western countries but has been increasing.

Methods: This is a hospital based descriptive study comprising of 120 consecutive patients with symptoms of gastroesophagial reflux disease belonging to both sexes of any age group. Read More

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July 2018
3 Reads

Endoscopic submucosal dissection for superficial esophageal cancer.

Authors:
A A Aadam S Abe

Dis Esophagus 2018 Jul;31(7)

Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.

Endoscopic submucosal dissection (ESD) has evolved into a viable treatment modality for superficial esophageal cancer. ESD offers a distinct advantage given the ability to perform en bloc resection enabling accurate histopathologic assessment. Data from published literature has established ESD as the preferred option in the treatment of superficial squamous cell carcinoma with complete resection rates of 78-100%, and a low rate recurrence of 0-2. Read More

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http://dx.doi.org/10.1093/dote/doy021DOI Listing

Recent advances in Barrett's esophagus.

Ann N Y Acad Sci 2018 Dec 5;1434(1):227-238. Epub 2018 Jul 5.

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

Barrett's esophagus (BE) is the only known precursor of esophageal adenocarcinoma, one of the few cancers with increasing incidence in developed countries. The pathogenesis of BE is unclear with regard to either the cellular origin of this metaplastic epithelium or the manner in which malignant transformation occurs, although recent data indicate a possible junctional origin of stem cells for BE. Treatment of BE may be achieved using endoscopic eradication therapy; however, there is a lack of discriminatory tools to identify individuals at sufficient risk for cancer development in whom intervention is warranted. Read More

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http://dx.doi.org/10.1111/nyas.13909DOI Listing
December 2018
4 Reads

Endoscopic diagnosis and treatment of esophageal adenocarcinoma: introduction of Japan Esophageal Society classification of Barrett's esophagus.

J Gastroenterol 2019 Jan 30;54(1):1-9. Epub 2018 Jun 30.

Department of Endoscopy, Saku Central Hospital Advanced Care Center, Saku, Japan.

Endoscopic surveillance of Barrett's esophagus has become a foundation of the management of esophageal adenocarcinoma (EAC). Surveillance for Barrett's esophagus commonly involves periodic upper endoscopy with biopsies of suspicious areas and random four-quadrant biopsies. However, targeted biopsies using narrow-band imaging can detect more dysplastic areas and thus reduce the number of biopsies required. Read More

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http://dx.doi.org/10.1007/s00535-018-1491-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314977PMC
January 2019
2 Reads

A Goblet (Cell) Half Full: What Do We Really Know About Barrett's Esophagus-A Tribute to Emmet Keeffe.

Dig Dis Sci 2018 08;63(8):1985-1987

Baylor University Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1007/s10620-018-5153-xDOI Listing
August 2018
1 Read

Evaluation of Dysplasia in Barrett Esophagus.

Gastroenterol Hepatol (N Y) 2018 Apr;14(4):233-239

Dr Gross is an associate professor of medicine, Dr Kingsbery and Dr Jang are resident physicians, and Dr Lee and Dr Khan are assistant professors of medicine in the Division of Gastroenterology and Hepatology at NYU Langone Health in New York, New York.

Barrett esophagus (BE) is the precursor lesion to adenocarcinoma of the esophagus. The current surveillance strategy of 4-quadrant Seattle protocol biopsies has been associated with sampling error and missing higher-risk lesions, and there is often less adherence to endoscopic surveillance with long segments. Advancements in endoscopic imaging and sampling techniques allow for better surveillance of BE, particularly when assessing for dysplasia. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009185PMC
April 2018
13 Reads

Newly developed magnifying endoscopic classification of the Japan Esophageal Society to identify superficial Barrett's esophagus-related neoplasms.

Esophagus 2018 Jun 19. Epub 2018 Jun 19.

Department of Endoscopy, Saku Central Hospital Advanced Care Center, Nagano, Japan.

Aim And Methods: The Japan Esophageal Society created a working committee group consisting of 11 expert endoscopists and 2 pathologists with expertise in Barrett's esophagus (BE) and esophageal adenocarcinoma. The group developed a consensus-based classification for the diagnosis of superficial BE-related neoplasms using magnifying endoscopy.

Results: The classification has three characteristics: simplified, an easily understood classification by incorporating the diagnostic criteria for the early gastric cancer, including the white zone and demarcation line, and the presence of a modified flat pattern corresponding to non-dysplastic histology by adding novel diagnostic criteria. Read More

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http://dx.doi.org/10.1007/s10388-018-0623-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021472PMC
June 2018
45 Reads

Can endoscopic resection for Barrett's dysplasia and early cancer be curative?

Ann N Y Acad Sci 2018 Dec 11;1434(1):54-58. Epub 2018 May 11.

Stanford Multidimensional Program for Innovation and Research in the Esophagus (S-MPIRE), Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California.

Effective endoscopic treatments for dysplasia and early (intramucosal) cancer, together with expanded and rigorous screening programs to detect Barrett's esophagus, could help reverse the increase in the incidence of esophageal cancer and reduce esophageal cancer-related mortality. In this review, we discuss the long-term outcomes for mucosal resection for dysplasia and early cancer and compares them to esophagectomy as the standard of care choice. Eendoscopic resection for Barrett's dysplasia and early cancer can be curative but only when the lesion can be classified as: Paris type I (polypoid); Paris IIa (slightly elevated); Paris IIb (flat); Paris IIc (slightly depressed); histological grades G1 and G2; high-grade dysplasia. Read More

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http://dx.doi.org/10.1111/nyas.13715DOI Listing
December 2018
3 Reads

How to get the most out of costly Barrett's oesophagus surveillance.

Dig Liver Dis 2018 09 22;50(9):871-877. Epub 2018 Apr 22.

Translation Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Current endoscopic surveillance protocols for Barrett's oesophagus have several limitations, mainly the poor cost-effectiveness and high miss rate. However, there is sufficient evidence that patients enrolled in a surveillance program have better survival chances of oesophageal cancer due to earlier tumor stages at diagnosis compared to patients with de novo diagnosed oesophagus cancer. Risk stratifications aim to identify patients at highest risk of developing adenocarcinoma of the oesophagus; most of them base on the length of the Barrett's segment and the presence of dysplasia. Read More

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http://dx.doi.org/10.1016/j.dld.2018.04.012DOI Listing
September 2018
2 Reads

Biomarkers of Barrett's Esophagus: From the Laboratory to Clinical Practice.

Dig Dis Sci 2018 08;63(8):2070-2080

Department of Medicine and the Center for Esophageal Diseases, Baylor University Medical Center at Dallas and the Center for Esophageal Research, Baylor Scott and White Research Institute, 2 Hoblitzelle, Suite 250, 3500 Gaston Avenue, Dallas, TX, 75246, USA.

The currently recommended approach to managing cancer risk for patients with Barrett's esophagus is endoscopic surveillance including a biopsy protocol to sample the esophageal tissue randomly to detect dysplasia. However, there are numerous limitations in this practice that rely on the histopathological grading of dysplasia alone to make clinical decisions. The availability of in silico models demonstrating the potential cost-effectiveness of biomarker-based stratification has increased interest in finding a clinically relevant "Barrett's biomarker. Read More

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http://dx.doi.org/10.1007/s10620-018-5088-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054820PMC
August 2018
3 Reads

Predictive features for early cancer detection in Barrett's esophagus using Volumetric Laser Endomicroscopy.

Comput Med Imaging Graph 2018 Jul 13;67:9-20. Epub 2018 Apr 13.

Department of Electrical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. Electronic address:

The incidence of Barrett cancer is increasing rapidly and current screening protocols often miss the disease at an early, treatable stage. Volumetric Laser Endomicroscopy (VLE) is a promising new tool for finding this type of cancer early, capturing a full circumferential scan of Barrett's Esophagus (BE), up to 3-mm depth. However, the interpretation of these VLE scans can be complicated, due to the large amount of cross-sectional images and the subtle grayscale variations. Read More

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http://dx.doi.org/10.1016/j.compmedimag.2018.02.007DOI Listing
July 2018
4 Reads

Future of diagnosing neoplasia in Barrett's esophagus: volumetric laser endomicroscopy.

Clin J Gastroenterol 2018 Jun 21;11(3):179-183. Epub 2018 Apr 21.

Department of Internal Medicine, Dow University of Health Sciences, Karachi, Pakistan.

Esophageal adenocarcinoma (EAC) is one of the deadliest carcinoma faced by gastroenterologists. Any insult to esophagus that causes replacement of normal squamous epithelium with columnar intestinal epithelium is labelled as the initiating event of the metaplasia-neoplasia sequence. Barrett's esophagus is the precursor to EAC. Read More

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http://dx.doi.org/10.1007/s12328-018-0863-3DOI Listing
June 2018
1 Read

How Should We Report Endoscopic Results in Patient's with Barrett's Esophagus?

Dig Dis Sci 2018 Aug;63(8):2115-2121

Department of Gastroenterology and Hepatology, Kansas City VA Medical Center, 4801 Linwood Boulevard, Kansas City, MO, 64128, USA.

Barrett's esophagus is the only known pre-cancerous lesion for esophageal adenocarcinoma and is diagnosed by high-definition white light endoscopy demonstrating a columnar-lined esophagus along with biopsy evidence of intestinal metaplasia. With accurate performance and reporting of the endoscopic procedure, an evidence-based management strategy can be developed for treatment of Barrett's dysplasia. However, cross-sectional data demonstrate that there is still inconsistency among gastroenterologists in performance and reporting of endoscopic findings in patients with Barrett's esophagus. Read More

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http://dx.doi.org/10.1007/s10620-018-5067-7DOI Listing
August 2018
3 Reads

Development of Evidence-Based Surveillance Intervals After Radiofrequency Ablation of Barrett's Esophagus.

Gastroenterology 2018 08 13;155(2):316-326.e6. Epub 2018 Apr 13.

University of North Carolina at Chapel Hill, Department of Medicine, Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, Chapel Hill, North Carolina. Electronic address:

Background & Aims: Barrett's esophagus (BE) recurs in 25% or more of patients treated successfully with radiofrequency ablation (RFA), so surveillance endoscopy is recommended after complete eradication of intestinal metaplasia (CEIM). The frequency of surveillance is informed only by expert opinion. We aimed to model the incidence of neoplastic recurrence, validate the model in an independent cohort, and propose evidence-based surveillance intervals. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067977PMC
August 2018
4 Reads

Emerging optical methods for endoscopic surveillance of Barrett's oesophagus.

Lancet Gastroenterol Hepatol 2018 05 6;3(5):349-362. Epub 2018 Apr 6.

Department of Physics, University of Cambridge, Cambridge, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. Electronic address:

Barrett's oesophagus is an acquired metaplastic condition that predisposes patients to the development of oesophageal adenocarcinoma, prompting the use of surveillance regimes to detect early malignancy for endoscopic therapy with curative intent. The currently accepted surveillance regime uses white light endoscopy together with random biopsies, but has poor sensitivity and discards information from numerous light-tissue interactions that could be exploited to probe structural, functional, and molecular changes in the tissue. Advanced optical methods are now emerging that are highly sensitive to these changes and hold potential to improve surveillance of Barrett's oesophagus if they can be applied endoscopically. Read More

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http://dx.doi.org/10.1016/S2468-1253(18)30030-XDOI Listing
May 2018
2 Reads

Volumetric laser endomicroscopy interpretation and feature analysis in dysplastic Barrett's esophagus.

J Gastroenterol Hepatol 2018 Oct 7;33(10):1761-1765. Epub 2018 May 7.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

Background And Aim: Volumetric laser endomicroscopy (VLE) is used to identify Barrett's esophagus (BE) dysplasia. Selection of a dysplastic region of interest (ROI) can be challenging due to feature variability across a large amount of data. The degree of agreement among VLE users in selecting a ROI has not been studied. Read More

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http://dx.doi.org/10.1111/jgh.14153DOI Listing
October 2018
12 Reads

Accuracy of probe-based confocal laser endomicroscopy (pCLE) compared to random biopsies during endoscopic surveillance of Barrett's esophagus.

Endosc Int Open 2018 Apr 29;6(4):E414-E420. Epub 2018 Mar 29.

Hunter Holmes McGuire VA Medical Center - Medicine (Gastroenterology), Richmond, Virginia, USA.

Background:  For surveillance of Barrett's esophagus (BE), the current standard of random 4-quadrant biopsies misses 10 - 50 % of esophageal neoplasms, and does not permit real-time decision-making. Probe-based confocal laser endomicroscopy (pCLE) permits real-time in vivo histologic assessment of esophageal mucosa during upper endoscopy. Prospective studies comparing the accuracy of pCLE to 4-quadrant biopsies in routine clinical practice are lacking. Read More

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http://dx.doi.org/10.1055/s-0043-124868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876024PMC

Introduction: Esophageal Adenocarcinoma: Updates of Current Status.

Authors:
Alfred K Lam

Methods Mol Biol 2018 ;1756:1-6

Cancer Molecular Pathology of School of Medicine, Griffith University, Gold Coast, Australia.

Esophageal and esophagogastric adenocarcinoma is highly prevalent in the Western populations and is a major cause of cancer-related morbidity and mortality worldwide. The incidence of esophageal adenocarcinoma is rapidly rising in the Western populations. The major predisposing diseases and pathogenesis (gastro-esophageal reflux disease, Barrett esophagus, and dysplasia) of the cancer are well known. Read More

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http://dx.doi.org/10.1007/978-1-4939-7734-5_1DOI Listing
January 2019
1 Read

New Screening Techniques in Barrett's Esophagus: Great Ideas or Great Practice?

Gastroenterology 2018 May 23;154(6):1594-1601. Epub 2018 Mar 23.

MRC Cancer Unit, Hutchinson/MRC Research Centre, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1053/j.gastro.2018.03.031DOI Listing

High rate of over-staging of Barrett's neoplasia with endoscopic ultrasound: Systemic review and meta-analysis.

Dig Liver Dis 2018 May 1;50(5):438-445. Epub 2018 Mar 1.

Division of Gastroenterology and Hepatology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, United States.

Background: The use of endoscopic ultrasound (EUS) to stage patients with Barrett's esophagus (BE) with suspected neoplasia is controversial due to high rates of over-staging. However, this rate of over-staging has not been adequately investigated or quantified.

Aim: To determine the rate of over-staging related EUS in this population. Read More

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http://dx.doi.org/10.1016/j.dld.2018.02.005DOI Listing
May 2018
12 Reads

Treatment Outcomes of Endoscopic Submucosal Dissection for Adenocarcinoma Originating from Long-Segment Barrett's Esophagus versus Short-Segment Barrett's Esophagus.

Digestion 2018 14;97(4):316-323. Epub 2018 Mar 14.

Background: In recent years, effective outcomes of endoscopic submucosal dissection (ESD) for esophagogastric junction cancer including short-segment Barrett's esophagus (SSBE) cancer have been reported. However, the efficacy of ESD for long-segment Barrett's esophagus (LSBE) cancer is unknown.

Aim: To clarify the treatment outcomes of ESD for LSBE cancer versus SSBE cancer. Read More

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http://dx.doi.org/10.1159/000486197DOI Listing
September 2018
7 Reads

Four cancer cases after esophageal atresia repair: Time to start screening the upper gastrointestinal tract.

World J Gastroenterol 2018 Mar;24(9):1056-1062

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam 3000 CA, Netherlands.

Esophageal atresia (EA) is one of the most common congenital digestive malformations and requires surgical correction early in life. Dedicated centers have reported survival rates up to 95%. The most frequent comorbidities after EA repair are dysphagia (72%) and gastroesophageal reflux (GER) (67%). Read More

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http://dx.doi.org/10.3748/wjg.v24.i9.1056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840470PMC
March 2018
4 Reads

Novel Developments in Endoscopic Mucosal Imaging.

Gastroenterology 2018 05 17;154(7):1876-1886. Epub 2018 Feb 17.

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

Endoscopic techniques such as high-definition and optical-chromoendoscopy have had enormous impact on endoscopy practice. Since these techniques allow assessment of most subtle morphological mucosal abnormalities, further improvements in endoscopic practice lay in increasing the detection efficacy of endoscopists. Several new developments could assist in this. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.01.070DOI Listing
May 2018
1 Read