985 results match your criteria Barrett's Esophagus Imaging


Multicenter study on the diagnostic performance of multiframe volumetric laser endomicroscopy targets for Barrett's esophagus neoplasia with histopathology correlation.

Dis Esophagus 2020 Jul 1. Epub 2020 Jul 1.

Department of Gastroenterology and Hepatology, Catharina Hospital, Eindhoven, The Netherlands.

Volumetric laser endomicroscopy (VLE) has been shown to improve detection of early neoplasia in Barrett's esophagus (BE). However, diagnostic performance using histopathology-correlated VLE regions of interest (ROIs) has not been adequately studied. We evaluated the diagnostic accuracy of VLE assessors for identification of early BE neoplasia in histopathology-correlated VLE ROIs. Read More

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http://dx.doi.org/10.1093/dote/doaa062DOI Listing

Fluorescence Imaging of Breast Tumors and Gastrointestinal Cancer.

Recent Results Cancer Res 2020 ;216:591-624

Klinik für Radiologie, St. Franziskus Hospital GmbH, Hohenzollernring 70, 48145, Münster, Germany.

Optical imaging offers a high potential for noninvasive detection and therapy of cancer in humans. Recent advances in instrumentation for diffuse optical imaging have led to new capabilities for the detection of cancer in highly scattering tissue such as the female breast. In particular, fluorescence imaging was made applicable as a sensitive technique to image molecular probes in vivo. Read More

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http://dx.doi.org/10.1007/978-3-030-42618-7_18DOI Listing
January 2020

Accuracy of artificial intelligence-assisted detection of upper GI lesions: a systematic review and meta-analysis.

Gastrointest Endosc 2020 Jun 17. Epub 2020 Jun 17.

Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong. Electronic address:

Background And Aims: Artificial intelligence (AI)-assisted detection is increasingly use in upper endoscopy. We performed a meta-analysis to determine the diagnostic accuracy of AI on detection of gastric and esophageal neoplastic lesions and Helicobacter pylori (HP) status.

Method: We searched Embase, PubMed, Medline, Web of Science and Cochrane databases for studies on AI detection of gastric or esophageal neoplastic lesions and HP status. Read More

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http://dx.doi.org/10.1016/j.gie.2020.06.034DOI Listing

Expert Assessment on Volumetric Laser Endomicroscopy Full-Scans in Barrett's Esophagus Patients With or Without High-Grade Dysplasia or Early Cancer.

Endoscopy 2020 Jun 8. Epub 2020 Jun 8.

Amsterdam UMC - Locatie AMC, Gastroenterology and Hepatology, Amsterdam, Netherlands.

Background: Volumetric laser endomicroscopy (VLE) allows for near-microscopic imaging of the superficial esophageal wall, and may improve detection of early neoplasia in Barrett's esophagus (BE). Interpretation of a 6-cm long, circumferential VLE "full-scan", may however be challenging for endoscopists.

Aim: To evaluate accuracy of VLE-experts for correctly diagnosing VLE full-scans of early neoplasia and non-dysplastic (ND)BE. Read More

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http://dx.doi.org/10.1055/a-1194-0397DOI Listing

A computer-assisted algorithm for narrow-band-imaging-based tissue characterization in Barrett's esophagus.

Gastrointest Endosc 2020 Jun 3. Epub 2020 Jun 3.

Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Background And Aims: The endoscopic evaluation of narrow-band imaging (NBI)-zoom imagery in Barrett's esophagus (BE) is associated with suboptimal diagnostic accuracy and poor interobserver agreement. Computer-aided diagnosis (CAD) systems may assist endoscopists in the characterization of Barrett's mucosa. Our aim was to demonstrate feasibility of a deep-learning CAD system for tissue characterization of NBI-zoom imagery in BE. Read More

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http://dx.doi.org/10.1016/j.gie.2020.05.050DOI Listing

Towards screening Barrett's oesophagus: current guidelines, imaging modalities and future developments.

Clin J Gastroenterol 2020 Jun 3. Epub 2020 Jun 3.

Biocel Ltd, Hull, HU10 7TS, UK.

Barrett's oesophagus is the only known precursor to oesophageal adenocarcinoma (OAC). Although guidelines on the screening and surveillance exist in Barrett's oesophagus, the current strategies are inadequate. Oesophagogastroduodenoscopy (OGD) is the gold standard method in screening for Barrett's oesophagus. Read More

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http://dx.doi.org/10.1007/s12328-020-01135-2DOI Listing

GIE Editorial Board top 10 topics: advances in GI endoscopy in 2019.

Gastrointest Endosc 2020 May 26. Epub 2020 May 26.

The ASGE's GIE Editorial Board reviewed original endoscopy-related articles published during 2019 in GIE and 10 other leading medical and gastroenterology journals. Votes from each individual member were tallied to identify a consensus list of 10 topic areas of major advances in GI endoscopy. Individual board members summarized important findings published in these 10 areas of disinfection, artificial intelligence, bariatric endoscopy, adenoma detection, polypectomy, novel imaging, Barrett's esophagus, third space endoscopy, interventional EUS, and training. Read More

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http://dx.doi.org/10.1016/j.gie.2020.05.021DOI Listing

High Content Imaging of Barrett's-Associated High-Grade Dysplasia Cells After siRNA Library Screening Reveals Acid-Responsive Regulators of Cellular Transitions.

Cell Mol Gastroenterol Hepatol 2020 May 13. Epub 2020 May 13.

Life Science Institute, University of British Columbia, Vancouver, British Columbia, Canada; Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Centre for Complement and Inflammation Research, Imperial College London, London, United Kingdom. Electronic address:

Background & Aims: Esophageal adenocarcinoma (EAC) develops from within Barrett's esophagus (BE) concomitant with gastroesophageal reflux disease (GERD). Wound healing processes and cellular transitions, such as epithelial-mesenchymal transitions, may contribute to the development of BE and the eventual migratory escape of metastatic cancer cells. Herein, we attempt to identify the genes underlying esophageal cellular transitions and their potential regulation by the low pH environments observed in GERD and commonly encountered by escaping cancer cells. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2020.05.002DOI Listing

SAGES TAVAC safety and efficacy analysis confocal laser endomicroscopy.

Surg Endosc 2020 May 13. Epub 2020 May 13.

VIP Surg. PLLC., Las Vegas, NV, USA.

Background: Confocal laser endomicroscopy (CLE) is a novel endoscopic adjunct that allows real-time in vivo histological examination of mucosal surfaces. By using intravenous or topical fluorescent agents, CLE highlights certain mucosal elements that facilitate an optical biopsy in real time. CLE technology has been used in different organ systems including the gastrointestinal tract. Read More

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http://dx.doi.org/10.1007/s00464-020-07607-3DOI Listing

C-Met targeted fluorescence molecular endoscopy in Barrett's esophagus patients and identification of outcome parameters for phase-I studies.

Theranostics 2020 6;10(12):5357-5367. Epub 2020 Apr 6.

Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands.

Fluorescence molecular endoscopy (FME) is an emerging technique in the field of gastroenterology that holds potential to improve diagnosis and guide therapy, by serving as a 'red-flag' endoscopic imaging technique. Here, we investigated the safety, feasibility and optimal method of administration of EMI-137, targeting c-Met, during FME in Barrett's Esophagus (BE) and report several outcome parameters for early phase FME studies. : FME was performed in 15 Barrett's neoplasia patients. Read More

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http://dx.doi.org/10.7150/thno.42224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196285PMC

Comparative quantitative survey of patient experience in Barrett's oesophagus and other gastrointestinal disorders.

BMJ Open Gastroenterol 2020 31;7(1):e000357. Epub 2020 Mar 31.

Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester and Manchester Academic Health Sciences Centre, Manchester, UK.

Objective: To assess health-related quality of life in patients with non-dysplastic Barrett's oesophagus (NDBO) and endoscopically treated dysplastic Barrett's oesophagus (DBO).

Design: This quantitative, self-administered questionnaire study was conducted across three National Health Service hospitals. Data were collected from three other cohorts; gastro-oesophageal reflux disease (GORD), colonic polyp surveillance and healthy individuals. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170407PMC

Establishing spectrochemical changes in the natural history of oesophageal adenocarcinoma from tissue Raman mapping analysis.

Anal Bioanal Chem 2020 Jul 25;412(17):4077-4087. Epub 2020 Apr 25.

School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, PR1 2HE, UK.

Raman spectroscopy is a fast and sensitive technique able to identify molecular changes in biological specimens. Herein, we report on three cases where Raman microspectroscopy was used to distinguish normal vs. oesophageal adenocarcinoma (OAC) (case 1) and Barrett's oesophagus vs. Read More

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http://dx.doi.org/10.1007/s00216-020-02637-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320044PMC

Current Status of Mucosal Imaging with Narrow-Band Imaging in the Esophagus.

Gut Liver 2020 Apr 22. Epub 2020 Apr 22.

Department of Gastroenterology, Lyell McEwin Hospital, Elizabeth Vale, Australia.

Recent advances in endoscopic imaging of the esophagus have revolutionized the diagnostic capability for detecting premalignant changes and early esophageal malignancy. In this article, we review the practical application of narrow-band imaging focusing on diseases of the esophagus, including Barrett's esophagus, adenocarcinoma, and squamous cell carcinoma. Read More

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http://dx.doi.org/10.5009/gnl20031DOI Listing

Parachute mitral valve assessed by cardiac magnetic resonance.

Interv Med Appl Sci 2019 Mar;11(1):65-67

Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Parachute mitral valve (PMV) is a congenital cardiac malformation where typically all tendons chordae converge and insert into one major papillary muscle. We report the case of 27-year-old man affected by Hodgkin's lymphoma-mixed cellularity subtype with polychemotherapy treatment and Barrett's esophagus who came to our attention for routine echocardiographic exam and evaluation of left ventricular function. In the presence of normal left ventricular systolic function and mild-moderate mitral regurgitation, a careful examination of mitral apparatus showed a single papillary muscle suspected for PMV. Read More

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http://dx.doi.org/10.1556/1646.11.2019.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044572PMC

[DIAGNOSTIC EFFICIENCY OF THE USE OF A MAGNIFYING CHROMOENDOSCOPY WHEN EXAMINING THE ORAL CAVITY IN PATIENTS WITH A GASTROENTEROLOGICAL PROFILE WITH EXTRAESOPHAGEAL MANIFESTATIONS OF REFLUX DISEASE].

Georgian Med News 2020 Jan(298):88-93

5Voronezh State Technical University, Russian Federation.

The article is devoted to the study of the diagnostic effectiveness of using magnifying chromoendoscopy when examining the oral cavity in patients with a gastroenterological profile with extra-esophageal manifestations of reflux disease. Pathologies of the oral cavity are often one of the additional symptoms, according to the Montreal Consensus and classification of gastroesophageal reflux disease (GERD). Barrett's esophagus is a serious complication of GERD, in which a cylindrical epithelium with intestinal metaplasia is found in the epithelial lining of the mucous membrane of the esophagus, which is a marker of this disease often in combination with dysplasia instead of squamous stratified non-keratinized epithelium. Read More

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January 2020

HIDA and Seek: Challenges of Scintigraphy to Diagnose Bile Reflux Post-Bariatric Surgery.

Obes Surg 2020 May;30(5):2038-2045

Discipline of Surgery, University of Adelaide, Adelaide, South Australia, Australia.

Introduction: Oesophageal bile reflux after bariatric surgery may trigger development of Barrett's oesophagus. Gastro-oesophageal reflux of bile is captured by hepatobiliary iminodiacetic acid (HIDA) scintigraphy; however, anatomical and physiological changes after bariatric surgery warrant protocol modifications to optimise bile reflux detection.

Methods: HIDA scintigraphy occurred 6 months after either sleeve gastrectomy, Roux-en-Y gastric bypass or one-anastomosis gastric bypass. Read More

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http://dx.doi.org/10.1007/s11695-020-04510-7DOI Listing

Seattle protocol vs narrow band imaging guided biopsy in screening of Barrett's esophagus in gastroesophageal reflux disease patients.

Medicine (Baltimore) 2020 Feb;99(8):e19261

Department of Internal Medicine, Faculty of Medicine, Alexandria University, Egypt.

Barrett's esophagus has 0.5% to 7% risk of progression to esophageal adenocarcinoma. The method of obtaining biopsies to diagnose Barrett's is challenging. Read More

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http://dx.doi.org/10.1097/MD.0000000000019261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034706PMC
February 2020

Deep principal dimension encoding for the classification of early neoplasia in Barrett's Esophagus with volumetric laser endomicroscopy.

Comput Med Imaging Graph 2020 Mar 24;80:101701. Epub 2020 Jan 24.

VCA Research Group, Eindhoven University of Technology, Eindhoven, The Netherlands.

Barrett cancer is a treatable disease when detected at an early stage. However, current screening protocols are often not effective at finding the disease early. Volumetric Laser Endomicroscopy (VLE) is a promising new imaging tool for finding dysplasia in Barrett's esophagus (BE) at an early stage, by acquiring cross-sectional images of the microscopic structure of BE up to 3-mm deep. Read More

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http://dx.doi.org/10.1016/j.compmedimag.2020.101701DOI Listing

Role of Multimodality Imaging in Gastroesophageal Reflux Disease and Its Complications, with Clinical and Pathologic Correlation.

Radiographics 2020 Jan-Feb;40(1):44-71

From the American Institute for Radiologic Pathology, 1100 Wayne Ave, Suite 1020, Silver Spring, MD 20910 (M.A.M.); Department of Radiology (M.A.M., A.D.L.) and Division of Gastroenterology and Hepatology (S.S.), MedStar Georgetown University Hospital, Washington, DC; the Joint Pathology Center, Silver Spring, Md (A.K.M.); and Georgetown University School of Medicine, Washington, DC (R.E.G.).

Gastroesophageal reflux disease (GERD) is a common condition and impairs the quality of life for millions of patients, accounts for considerable health care spending, and is a primary risk factor for esophageal adenocarcinoma. There have been substantial advances in understanding the pathogenesis of GERD and its complications and much progress in diagnosis and management of GERD; however, these have not been comprehensively discussed in the recent radiology literature. Understanding the role of imaging in GERD and its complications is important to aid in multidisciplinary treatment of GERD. Read More

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http://dx.doi.org/10.1148/rg.2020190029DOI Listing
January 2020

Approach to the Post-Ablation Barrett's Esophagus Patient.

Am J Gastroenterol 2020 Jun;115(6):823-831

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

Because of the rising incidence and lethality of esophageal adenocarcinoma, Barrett's esophagus (BE) is an increasingly important premalignant target for cancer prevention. BE-associated neoplasia can be safely and effectively treated with endoscopic eradication therapy (EET), incorporating tissue resection and ablation. Because EET has proliferated, managing patients after complete eradication of intestinal metaplasia has taken on increasing importance. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000514DOI Listing

Diagnosing dysplasia in Barrett's oesophagus still requires Seattle protocol biopsy in the era of modern video endoscopy: results from a tertiary centre Barrett's dysplasia database.

Scand J Gastroenterol 2020 Jan 27;55(1):9-13. Epub 2019 Dec 27.

NIHR Nottingham Digestive Diseases and Biomedical Research Centre, Nottingham, UK.

The role of random, four-quadrant biopsy (i.e. systematic biopsy) in Barrett's oesophagus surveillance has been questioned given its drawbacks and the emergence of high-resolution endoscopy and advanced imaging modalities. Read More

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http://dx.doi.org/10.1080/00365521.2019.1706762DOI Listing
January 2020

Adjunctive Yield of Wide-Area Transepithelial Sampling for Dysplasia Detection After Advanced Imaging and Random Biopsies in Barrett's Esophagus.

Clin Transl Gastroenterol 2019 12;10(12):e00107

Division of Gastroenterology, Zucker School of Medicine at Hofstra/Northwell, Long Island Jewish Medical Center, Northwell Health System, New Hyde Park, New York, USA.

Introduction: Little is known about the additive yield of wide-area transepithelial sampling with computer-assisted three-dimensional analysis (WATS-3D) after a thorough examination with advanced imaging. The aim was to evaluate the adjunctive yield of WATS-3D after advanced imaging.

Methods: This is an observational cohort study from January 2017 to December 2018 for consecutive patients who underwent an examination that consists of high-definition white light endoscopy (HDWLE), narrow-band imaging (NBI), volumetric laser endomicroscopy (VLE), and Seattle protocol (SP) biopsies (collectively termed HDWLE-NBI-VLE-SP examination). Read More

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http://dx.doi.org/10.14309/ctg.0000000000000107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970552PMC
December 2019

Diffuse endoscopically visible, predominantly low grade dysplasia in Barrett's esophagus (with video).

Endosc Int Open 2019 Dec 10;7(12):E1742-E1747. Epub 2019 Dec 10.

St. Vincent's Hospital, Department of Gastroenterology, Fitzroy, Victoria, Australia.

 Low grade dysplasia (LGD) in Barrett's esophagus (BE) has generally been considered as undetectable endoscopically.  To describe a phenotype which consists of diffuse, endoscopically visible, predominantly low grade dysplasia in Barrett's esophagus (DEVLB), with often subtle but visible endoscopic changes seen with high definition white light (HDWL) and narrow-band imaging (NBI).  A systematic search of a prospectively collected database for patients satisfying predefined criteria for DEVLB and a review of endoscopic and histological features of biopsies and endoscopic mucosal resection (EMR) specimens. Read More

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http://dx.doi.org/10.1055/a-1031-9327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904234PMC
December 2019

Consensus statement of the Hellenic and Cypriot Oesophageal Cancer Study Group on the diagnosis, staging and management of oesophageal cancer.

Updates Surg 2019 Dec 2;71(4):599-624. Epub 2019 Dec 2.

Department of General Surgery, Creta Interclinic Hospital, Heraklion, Greece.

In spite of recent advances in the diagnosis and management of oesophageal cancer, the overall survival of the disease worldwide remains disappointingly low. In Greece and Cyprus, this may be partly due to a failure of health care providers to implement standardised treatment protocols in clinical practice. Development of clinical practice guidelines was undertaken as a joint project between the Hellenic Society of Medical Oncology (HeSMO) and Gastro-Intestinal Cancer Study Group (GIC-SG) in an effort to provide guidance for Greek and Cypriot clinicians in all aspects of the management of oesophageal cancer. Read More

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http://dx.doi.org/10.1007/s13304-019-00696-3DOI Listing
December 2019

Deep-Learning System Detects Neoplasia in Patients With Barrett's Esophagus With Higher Accuracy Than Endoscopists in a Multistep Training and Validation Study With Benchmarking.

Gastroenterology 2020 03 22;158(4):915-929.e4. Epub 2019 Nov 22.

Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

Background & Aims: We aimed to develop and validate a deep-learning computer-aided detection (CAD) system, suitable for use in real time in clinical practice, to improve endoscopic detection of early neoplasia in patients with Barrett's esophagus (BE).

Methods: We developed a hybrid ResNet-UNet model CAD system using 5 independent endoscopy data sets. We performed pretraining using 494,364 labeled endoscopic images collected from all intestinal segments. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.11.030DOI Listing

Volumetric laser endomicroscopy features of dysplasia at the gastric cardia in Barrett's oesophagus: results from an observational cohort study.

BMJ Open Gastroenterol 2019 23;6(1):e000340. Epub 2019 Oct 23.

Division of Gastroenterology, Zucker School of Medicine at Hofstra/Northwell, Long Island Jewish Medical Center, Northwell Health System, New Hyde Park, New York, USA.

Objective: Volumetric laser endomicroscopy (VLE) is an advanced imaging modality used in Barrett's oesophagus (BE) to help identify dysplasia in the oesophagus. VLE criteria exist for oesophageal dysplasia but not for dysplasia in the gastric cardia. The aim of this study was to determine if there are in vivo VLE features that can predict gastric cardia dysplasia in BE. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827805PMC
October 2019

AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.

Gastroenterology 2020 02 12;158(3):760-769. Epub 2019 Nov 12.

Amsterdam University Medical Center, Amsterdam, The Netherlands.

Description: The purpose of this best practice advice article is to describe the role of Barrett's endoscopic therapy (BET) in patients with Barrett's esophagus (BE) with dysplasia and/or early cancer and appropriate follow-up of these patients.

Methods: The best practice advice provided in this document is based on evidence and relevant publications reviewed by the committee. BEST PRACTICE ADVICE 1: In BE patients with confirmed low-grade dysplasia, a repeat examination with high-definition white-light endoscopy should be performed within 3-6 months to rule out the presence of a visible lesion, which should prompt endoscopic resection. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.09.051DOI Listing
February 2020

Utilization of Surveillance Endoscopy for Barrett's Esophagus in Medicare Enrollees.

Gastroenterology 2020 02 31;158(3):773-775.e1. Epub 2019 Oct 31.

Center for Clinical Management Research, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan; Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan; Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1053/j.gastro.2019.10.022DOI Listing
February 2020

Time Trends in Adherence to Surveillance Intervals and Biopsy Protocol Among Patients With Barrett's Esophagus.

Gastroenterology 2020 02 14;158(3):770-772.e2. Epub 2019 Oct 14.

University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1053/j.gastro.2019.10.004DOI Listing
February 2020

Development and validation of the international Blue Light Imaging for Barrett's Neoplasia Classification.

Gastrointest Endosc 2020 02 3;91(2):310-320. Epub 2019 Oct 3.

Department of Gastroenterology, Queen Alexandra Hospital, Portsmouth, United Kingdom.

Background And Aims: Detecting subtle Barrett's neoplasia during surveillance endoscopy can be challenging. Blue-light imaging (BLI) is a novel advanced endoscopic technology with high-intensity contrast imaging that may improve the identification of Barrett's neoplasia. The aim of this study was to develop and validate the first classification to enable characterization of neoplastic and non-neoplastic Barrett's esophagus using BLI. Read More

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http://dx.doi.org/10.1016/j.gie.2019.09.035DOI Listing
February 2020

Volumetric laser endomicroscopy and optical coherence tomography in Barrett's esophagus: a systematic review and meta-analysis.

Endosc Int Open 2019 Sep 29;7(9):E1078-E1091. Epub 2019 Aug 29.

Department of Endoscopy, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.

Endoscopic imaging of Barrett's esophagus (BE) with advanced technologies, such as optical coherence tomography (OCT) and volumetric laser endomicroscopy (VLE), allows targeted biopsies and may reduce the number of random biopsies to detect esophageal neoplasia in the early stages during endoscopic BE surveillance. The aim of this study was to evaluate the accuracy of OCT and VLE in diagnosis of intestinal metaplasia, dysplasia, and high-grade dysplasia (HGD), and intramucosal carcinoma (IMC) in BE.  In this systematic review and meta-analysis, the primary outcome measure was diagnostic accuracy of OCT and VLE, in comparison with the gold standard. Read More

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http://dx.doi.org/10.1055/a-0965-6487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715432PMC
September 2019
2 Reads

Issues and controversies in esophageal inlet patch.

World J Gastroenterol 2019 Aug;25(30):4061-4073

Department of Gastroenterology, Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania.

The proximal esophagus is rarely examined, and its inspection is often inadequate. Optical chromoendoscopy techniques such as narrow band imaging improve the detection rate of inlet patches in the proximal esophagus, a region in which their prevalence is likely underestimated. Various studies have reported correlations between these esophageal marks with different issues such as Barrett's esophagus, but these findings remain controversial. Read More

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http://dx.doi.org/10.3748/wjg.v25.i30.4061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700698PMC
August 2019
1 Read

Adherence to pre-set benchmark quality criteria to qualify as expert assessor of dysplasia in Barrett's esophagus biopsies - towards digital review of Barrett's esophagus.

United European Gastroenterol J 2019 08 21;7(7):889-896. Epub 2019 May 21.

Department of Pathology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.

Background: Dysplasia assessment of Barrett's esophagus biopsies is associated with low observer agreement; guidelines advise expert review. We have developed a web-based review panel for dysplastic Barrett's esophagus biopsies.

Objective: The purpose of this study was to test if 10 gastrointestinal pathologists working at Dutch Barrett's esophagus expert centres met pre-set benchmark scores for quality criteria. Read More

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http://dx.doi.org/10.1177/2050640619853441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683647PMC

Management of Barrett Esophagus Following Radiofrequency Ablation.

Gastroenterol Hepatol (N Y) 2019 Jul;15(7):377-386

Dr Reed is a clinical instructor of medicine and Dr Shaheen is a professor of medicine and epidemiology in the Division of Gastroenterology and Hepatology in the Department of Medicine at the University of North Carolina School of Medicine in Chapel Hill, North Carolina.

Radiofrequency ablation (RFA) effectively treats dysplastic Barrett esophagus (BE), reduces the risk of esophageal adenocarcinoma (EAC), and infrequently produces complications. Complications of RFA include chest discomfort, esophageal stricturing, and bleeding. However, chest discomfort is usually transient and mild, strictures are generally amenable to dilation, and clinically significant bleeding is rare. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676349PMC
July 2019
1 Read

Comparison of narrow-band imaging, volumetric laser endomicroscopy, and pathologic findings in Barrett's esophagus.

VideoGIE 2019 Jul 23;4(7):319-322. Epub 2019 May 23.

Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Arizona, USA.

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http://dx.doi.org/10.1016/j.vgie.2019.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617129PMC
July 2019
1 Read

Prevalence and risk factors for Barrett's esophagus in Taiwan.

World J Gastroenterol 2019 Jul;25(25):3231-3241

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan.

Background: Barrett's esophagus (BE) is a pre-malignant condition associated with the development of esophageal adenocarcinoma. The prevalence of BE in the general populations of Asian countries ranges from 0.06% to 1%. Read More

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http://dx.doi.org/10.3748/wjg.v25.i25.3231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626729PMC
July 2019
2 Reads

Advanced imaging in surveillance of Barrett's esophagus: Is the juice worth the squeeze?

World J Gastroenterol 2019 Jul;25(25):3108-3115

Division of Gastroenterology, Long Island Jewish Medical Center, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, New Hyde Park, NY 11040, United States.

Esophageal cancer is on the rise. The known precursor lesion is Barrett's esophagus (BE). Patients with dysplasia are at higher risk of developing esophageal cancer. Read More

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http://dx.doi.org/10.3748/wjg.v25.i25.3108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626724PMC
July 2019
3 Reads

Case 268: Bilateral Adrenal Hemorrhage in the Context of Sepsis.

Radiology 2019 08;292(2):503-506

From the Department of Radiology, Norfolk and Norwich University Hospitals, Colney Lane, Norwich NR4 7UY, England.

History A 65-year-old man presented to the emergency department with a 1-week history of constipation, which was associated with increasing abdominal distention and not passing flatus. Four weeks prior to the current admission he had been diagnosed with metastatic primary adenocarcinoma of the appendix. One week ago, he had been hospitalized with small-bowel obstruction, for which he required laparotomy and loop ileostomy. Read More

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http://dx.doi.org/10.1148/radiol.2019170489DOI Listing
August 2019
2 Reads

Adherence to clinical guidelines for Barrett's esophagus.

Scand J Gastroenterol 2019 Aug 17;54(8):945-952. Epub 2019 Jul 17.

Department of Molecular Medicine and Surgery, Upper Gastrointestinal Surgery, Karolinska Institutet, Karolinska University Hospital , Stockholm , Sweden.

Clinical guidelines recommend endoscopy surveillance at given intervals or endoscopic therapy for Barrett's esophagus with low-grade dysplasia (LGD) and high-grade dysplasia (HGD). Whether these guidelines are followed in clinical practice is unknown and was assessed in this study. This nationwide Swedish cohort study included patients with Barrett's esophagus with histologically verified LGD or HGD from 50 centers in 2006-2013. Read More

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http://dx.doi.org/10.1080/00365521.2019.1641740DOI Listing
August 2019
5 Reads

Imaging for Barrett's esophagus: state of the art.

Curr Opin Gastroenterol 2019 09;35(5):395-400

University of Kansas Medical Center.

Purpose Of Review: Barrett's esophagus is the premalignant condition for esophageal cancer and the diagnosis of esophageal adenocarcinoma on index endoscopy is increasing. Many advanced endoscopic techniques are available and aim to identify Barrett's esophagus-associated neoplasia earlier, thereby preventing progression into malignancy.

Recent Findings: It is well established adherence to Seattle protocol increases dysplasia detection but leaves large portions of mucosa unsampled. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000557DOI Listing
September 2019

Clinical characteristics of young patients with early Barrett's neoplasia.

World J Gastroenterol 2019 Jun;25(24):3069-3078

Advanced Therapeutic Endoscopy Centre, St Michael's Hospital, University of Toronto, Toronto M5B 1W8, Ontario, Canada.

Background: Esophageal adenocarcinoma (EAC) and high-grade dysplasia (HGD) may appear in young patients with Barrett's esophagus (BE). However, characteristics of Barrett's-related neoplasia in this younger population remain unknown.

Aim: To identify clinical characteristics that differ between young and old patients with early-stage Barrett's-related neoplasia. Read More

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http://dx.doi.org/10.3748/wjg.v25.i24.3069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603815PMC
June 2019
2 Reads

CAESNet: Convolutional AutoEncoder based Semi-supervised Network for improving multiclass classification of endomicroscopic images.

J Am Med Inform Assoc 2019 11;26(11):1286-1296

Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, Georgia, USA.

Objective: This article presents a novel method of semisupervised learning using convolutional autoencoders for optical endomicroscopic images. Optical endomicroscopy (OE) is a newly emerged biomedical imaging modality that can support real-time clinical decisions for the grade of dysplasia. To enable real-time decision making, computer-aided diagnosis (CAD) is essential for its high speed and objectivity. Read More

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http://dx.doi.org/10.1093/jamia/ocz089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798571PMC
November 2019
3 Reads

Multispectral Endoscopy with Light Gating for Early Cancer Detection.

IEEE J Sel Top Quantum Electron 2019 Jan-Feb;25(1). Epub 2018 Jul 9.

Biological and Biomedical Sciences Program, and also with Center for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02115 USA.

This paper reports the application of endoscopic light scattering spectroscopy (LSS) with light gating to detect malignancies in the biliary and pancreatic ducts, and also reviews the application of endoscopic LSS for differentiating cystic neoplasms in the pancreas and detecting invisible dysplasia in Barrett's esophagus. Information about tissue structure within the superficial epithelium where malignancy starts is present within the spectra of reflected light. Fortunately, this component of the reflected light is not yet randomized. Read More

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http://dx.doi.org/10.1109/JSTQE.2018.2854608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594557PMC
July 2018
7 Reads
2.828 Impact Factor

Long-term (15-year) objective evaluation of 150 patients after laparoscopic Nissen fundoplication.

Surgery 2019 11 19;166(5):886-894. Epub 2019 Jun 19.

Department of Surgery, University Hospital, University of Chile, Santiago, Chile.

Introduction: Laparoscopic Nissen fundoplication is the preferred operative treatment for patients with gastroesophageal reflux disease. The most recent published results only refer to clinical evaluations and few discuss objective measurements. Our purpose was to determine the late results of laparoscopic Nissen fundoplication, performing clinical, endoscopic, histologic, and functional studies. Read More

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http://dx.doi.org/10.1016/j.surg.2019.04.024DOI Listing
November 2019
19 Reads

CHROMOENDOSCOPY USING TOLUIDINE BLUE PLUS LUGOL'S SOLUTION FOR EARLY DIAGNOSIS OF ESOPHAGEAL PREMALIGNANT LESIONS AND SUPERFICIAL NEOPLASMS IN HIGH-RISK PATIENTS.

Arq Gastroenterol 2019 Jan-Mar;56(1):41-44. Epub 2019 Mar 18.

Department of Gastroenterology. Hospital Militar "Dr. Carlos Arvelo", Caracas, Venezuela.

Background: Esophageal cancer is the eighth most common cancer. The prognosis is bleak in patients with advanced stages. Patients with early disease have a better prognosis than those with advanced stage. Read More

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http://dx.doi.org/10.1590/S0004-2803.201900000-01DOI Listing
July 2019
2 Reads

Therapeutic options for early cancer of the esophagogastric junction.

Cir Esp 2019 Oct 26;97(8):438-444. Epub 2019 May 26.

Servicio de Cirugía General y Digestiva, Hospital de la Santa Creu i Sant Pau, UAB, Barcelona, España. Electronic address:

Early-stage (T1) esophagogastric junction cancer continues to represent 2-3% of all cases. Adenocarcinoma is the most frequent and important type, the main risk factors for which are gastroesophageal reflux and Barrett's esophagus with dysplasia. Patients with mucosal (T1a) or submucosal (T1b) involvement initially require a thorough digestive endoscopy, and narrow-band imaging can improve visualization. Read More

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http://dx.doi.org/10.1016/j.ciresp.2019.04.001DOI Listing
October 2019
28 Reads

Clinical translational application of Raman spectroscopy to advance Benchside biochemical characterization to bedside diagnosis of esophageal diseases.

J Gastroenterol Hepatol 2019 Nov 16;34(11):1911-1921. Epub 2019 Jul 16.

Vanderbilt Biophotonics Center, Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.

Esophageal diseases result in significant mortality, morbidity, and health care costs worldwide. Current approaches to detect and monitor esophageal diseases have severe limitations. Advanced imaging technologies are being developed to complement current approaches to improve diagnostic, therapeutic and surveillance protocols in order to advance the field. Read More

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http://dx.doi.org/10.1111/jgh.14738DOI Listing
November 2019
7 Reads

Evolving screening and surveillance techniques for Barrett's esophagus.

World J Gastroenterol 2019 May;25(17):2045-2057

Basil Hirschowitz Endoscopic Centre of Endoscopic Excellence, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL 35294, United Sates.

Barrett's esophagus (BE) is a change in the esophageal lining and is known to be the major precursor lesion for most cases of esophageal adenocarcinoma (EAC). Despite an understanding of its association with BE for many years and the falling incidence rates of squamous cell carcinoma of the esophagus, the incidence for EAC continues to rise exponentially. In association with this rising incidence, if the delay in diagnosis of EAC occurs after the onset of symptoms, then the mortality at 5 years is greater than 80%. Read More

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http://dx.doi.org/10.3748/wjg.v25.i17.2045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506582PMC
May 2019
4 Reads