8,283 results match your criteria Barrett's Esophagus Imaging


Endoscopic therapy for confirmed low-grade dysplasia in Barrett's esophagus.

Transl Gastroenterol Hepatol 2018 29;3:83. Epub 2018 Oct 29.

Unità Operativa Complessa di Endoscopia Digestiva Chirurgica, Dipartimento Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche Istituto di Clinica Chirurgica Generale e Terapia Chirurgica Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Roma, Italia.

Barrett's esophagus (BE) is a premalignant condition characterized by replacement of the esophageal lining with metastatic columnar epithelium. To date, the management in case of confirmed low-grade dysplasia (LGD) remains controversial. In this article we summarize the available endoscopic options and their results in terms of efficacy and safety in the treatment of confirmed LGD in BE. Read More

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October 2018
1 Read

Minimally invasive esophagectomy for Barrett's adenocarcinoma.

Transl Gastroenterol Hepatol 2018 16;3:77. Epub 2018 Oct 16.

Department of Biomedical Sciences for Health, Division of General Surgery, IRCCS Policlinico San Donato, University of Milan, Italy.

Minimally invasive esophagectomy has become the preferred approach for invasive Barrett's adenocarcinoma because it can speed recovery and enhance patient's quality of life. Multiple minimally invasive surgical techniques have been described during the last two decades. Preoperative staging, anatomy and physiological patient's status, comorbidity, and experience of the surgical team should drive the choice of the surgical approach. Read More

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October 2018

Facteurs en cause et formes cliniques du reflux gastro-oesophagien chez l’adulte. Une prévalence élevée qui augmente avec l’âge.

Rev Prat 2016 Dec;66(10):1080-1083

Explorations fonctionnelles digestives, hôpital Pontchaillou, Rennes, France.

Factors and clinical forms of gastroesophageal reflux disease in adults. Gastro-oesophageal reflux (GERD) is a common complaint. Factors involved in GERD are the antireflux barrier dysfunction, the oesophageal sensitivity disorders, impaired oesophageal clearance, the acid component of the refluxate, and impaired gastric emptying. Read More

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December 2016

Benefits of the Seattle biopsy protocol in the diagnosis of Barrett's esophagus in a Chinese population.

World J Clin Cases 2018 Nov;6(14):753-758

Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.

Aim: To investigate the benefits of the Seattle protocol in the diagnosis of Chinese individuals with Barrett's esophagus.

Methods: Subjects enrolled were patients from one center with endoscopically-suspected esophageal metaplasia. These patients first received narrow-band imaging-targeted biopsy, and later, the Seattle protocol-guided biopsy, within a period from October 2012 to December 2014. Read More

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November 2018

A biomarker panel predicts progression of Barrett's esophagus to esophageal adenocarcinoma.

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Medical Research Council Cancer Unit, Hutchison-MRC Research Center, University of Cambridge,Cambridge,United Kingdom.

Progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) is uncommon but the consequences are serious. Predictors of progression are essential to optimize resource utilization. This study assessed the utility of a promising panel of biomarkers applicable to routine paraffin embedded biopsies (FFPE) to predict progression of BE to EAC in a large population-based, nested case-control study. Read More

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November 2018
2 Reads

Cryotherapy in the management of premalignant and malignant conditions of the esophagus.

World J Gastroenterol 2018 Nov;24(43):4862-4869

Department of Gastroenterology, Digestive Disease Surgery Institute, Cleveland Clinic, Cleveland, OH 44195, United States.

Endoscopic cryotherapy is a relatively new thermal ablative modality used for the treatment of neoplastic lesions of the esophagus. It relies on cycles of rapid cooling and thawing to induce tissue destruction with a cryogen (liquid nitrogen or carbon dioxide) leading to intra and extra-cellular damage. Surgical treatment was once considered the standard therapeutic intervention for neoplastic diseases of the esophagus and is associated with considerable rates of morbidity and mortality. Read More

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November 2018
5 Reads

Campylobacter Concisus and Its Effect on the Expression of CDX1 and COX2

Asian Pac J Cancer Prev 2018 Nov 29;19(11):3211-3216. Epub 2018 Nov 29.

Department of Microbiology of Pathobiology, School of Public Health, Tehran University of Medical Sciences, International Campus (TUMS-IC), Tehran, Iran.

Background: Barrett’s oesophagus (BO) is a pre-malignant condition in which normal squamous epithelium of the lower oesophagus and gastresophageal junction is replaced by columnar cells and progress to oesophageal adenocarcinoma. The increase burden of oesophagus cancer morbidity and mortality worldwide make study of factors involved in the pathogenesis of BO essential. However, most of studies that examine the environmental risk factors associated with increased incidence and prevalence of BO have largely ignored the potential role of bacteria in disease aetiology. Read More

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November 2018

The incidence of esophageal cancer and dysplasia in a Chinese population with nondysplastic Barrett's esophagus.

JGH Open 2018 Oct 9;2(5):214-216. Epub 2018 Aug 9.

Division of Gastroenterology, Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan.

Aim: The aim of this study was to investigate the incidence of dysplastic transformation of Barrett's esophagus (BE) in a Chinese population.

Method: Data from nondysplastic BE patients at Taichung Veterans General Hospital were collected from May 2008 to June 2017. The enrolled individuals received regular upper gastrointestinal (UGI) endoscopy during follow up. Read More

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October 2018
3 Reads

Adiponectin level changes among Egyptians with gastroesophageal reflux disease.

JGH Open 2018 Feb 28;2(1):21-27. Epub 2018 Jan 28.

Department of Internal Medicine, Faculty of Medicine AL-Azhar University Assiut Egypt.

Background And Aim: Visceral fat is an important endocrine organ that secretes different bioactive substances such as adipocytokines. The aim of this study was to investigate the adiponectin level changes among patients with erosive gastroesophageal reflux disease (GERD)and its consequence on pathogenesis.

Methods: In this study, 150 subjects were selected and divided into four groups: Group І ( = 40) were healthy individuals with an average body mass index and had no gastrointestinal tract symptoms; Group ІІ ( = 50) were patients with mild to moderate erosive esophagitis; Group ІІІ ( = 40) were patients with severe erosive esophagitis; and finally, Group ІV ( = 20) were patients with Barrett's esophagus. Read More

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February 2018
3 Reads

Risk stratifying the screening of Barrett's esophagus: An Asian perspective.

JGH Open 2017 Oct 11;1(2):68-73. Epub 2017 Oct 11.

Department of Medicine National University Hospital Singapore.

Background And Aim: Barrett's esophagus (BE) is a premalignant condition for esophageal adenocarcinoma. Although risk factors exist for screening patients in the West, we aimed to determine the factors in terms of demographics and symptoms for patients in an Asian setting.

Methods: We recruited 1378 patients over a 7-year period as part of an ongoing gastric cancer screening program. Read More

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October 2017

The Present Status and Future of Barrett's Esophageal Adenocarcinoma in Japan.

Digestion 2018 Nov 27:1-6. Epub 2018 Nov 27.

Division of Gastroenterological Surgery, Tokai University, Oiso, Japan.

Background: The incidence of esophageal adenocarcinoma in Europe and the United States rapidly increased from the latter half of the 1970s and exceeded that of esophageal squamous cell carcinoma in the latter half of the 1990s, currently accounting for approximately 60% of all esophageal carcinomas. Recently, its incidence has also increased in Japan, raising concerns that it will follow a course similar to that in Europe and the United States.

Summary: The incidence of esophageal adenocarcinoma in Japan was about 2% until the 1990s, but in recent years, it has risen to 6. Read More

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November 2018
3 Reads

Prevalence and Natural History of Barrett's Esophagus in Lung Transplant: A Single-Center Experience.

Ann Thorac Surg 2018 Nov 24. Epub 2018 Nov 24.

Division of Thoracic Surgery, Norton Thoracic Institute; St Joseph's Hospital and Medical Center, Phoenix, Arizona. Electronic address:

Background: Barrett's esophagus (BE)-intestinal metaplasia in the esophagus-may progress to low-grade dysplasia (LGD), high-grade dysplasia (HGD), and ultimately, invasive esophageal adenocarcinoma (EAC). The course of BE in immunosuppressed lung transplant recipients is unknown.

Methods: We retrospectively reviewed the records of patients who underwent lung transplant at our center between 01/01/2010 and 10/31/2016. Read More

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November 2018
1 Read

A cost-effectiveness analysis of endoscopic eradication therapy (EET) for management of dysplasia arising in patients with Barrett's esophagus in the United Kingdom.

Curr Med Res Opin 2018 Nov 27:1-29. Epub 2018 Nov 27.

a Department of Gastroenterology , University College London Hospital , United Kingdom.

Background And Aims: Endoscopic eradication therapy (EET) is the first line approach for treating Barrett's Esophagus (BE) related neoplasia globally. The British Society of Gastroenterology (BSG) recommend EET with combined endoscopic resection (ER) for visible dysplasia followed by endoscopic ablation in patients with both low and high grade dysplasia (LGD and HGD). The aim of this study is to perform a cost-effectiveness analysis for EET for treatment of all grades of dysplasia in BE patients. Read More

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November 2018

Preferences for Surveillance of Barrett's Oesophagus: a Discrete Choice Experiment.

J Gastrointest Surg 2018 Nov 26. Epub 2018 Nov 26.

Flinders Centre for Innovation in Cancer, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5041, Australia.

Purpose: Endoscopic surveillance for Barrett's oesophagus is undertaken to detect dysplasia and early cancer, and to facilitate early intervention. Evidence supporting current practice is of low quality and often influenced by opinion. This study investigated the preferences of patients for surveillance of Barrett's oesophagus in an Australian cohort. Read More

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November 2018
7 Reads

Cystic fibrosis is associated with an increased risk of Barrett's esophagus.

J Cyst Fibros 2018 Nov 22. Epub 2018 Nov 22.

Division of Digestive & Liver Diseases, Columbia University Medical Center, New York, NY, USA.

Background: Cystic fibrosis (CF) patients have increased risks of gastrointestinal cancers, including esophageal adenocarcinoma. Gastroesophageal reflux disease (GERD) is highly prevalent in CF and manifests at early ages. CF patients may be at increased risk for long-term sequelae of chronic GERD, including Barrett's esophagus (BE). Read More

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November 2018
1 Read

Preoperative Gastroesophageal Reflux Disorder Is Associated With Increased Morbidity in Patients Undergoing Abdominal Surgery.

J Surg Res 2018 Dec 8;232:587-594. Epub 2018 Aug 8.

Department of Surgery, University of Virginia, Charlottesville, Virginia.

Background: In North America, the prevalence of gastroesophageal reflux disorder ranges from 18.1% to 27.8%. Read More

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December 2018
2 Reads

The overlap syndrome of urticaria and gastroesophageal reflux disease.

PLoS One 2018 20;13(11):e0207602. Epub 2018 Nov 20.

Aggregate Post Graduate School in Allergology and Clinical Immunology of Campania University L. Vanvitelli, Naples, Italy and of Federico II University, Naples, Italy.

Background: One-quarter of systemic symptoms associated with chronic spontaneous urticaria (CSU) are related to gastrointestinal complaints (GICs).

Objectives: To investigate the prevalence and features of urticaria-overlapping GICs.

Methods: In this retrospective cross-sectional survey, 1426 consecutive outpatients were observed at our University Department. Read More

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November 2018
3 Reads

Results of a two-phased clinical study evaluating a new multiband mucosectomy device for early Barrett's neoplasia: a randomized pre-esophagectomy trial and a pilot therapeutic pilot study.

Surg Endosc 2018 Nov 19. Epub 2018 Nov 19.

Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Background: Multiband mucosectomy (MBM) is the preferred technique for piecemeal resection of early neoplastic lesions in Barrett's esophagus (BE). The currently most widely used device for MBM is the Duette device. Recently, the Captivator EMR device has come available which might have practical advantages over the Duette device. Read More

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November 2018
3 Reads

Clinical prediction model for tumor progression in Barrett's esophagus.

Surg Endosc 2018 Nov 19. Epub 2018 Nov 19.

Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Norra Stationsgatan 67, Solna (L1:00), 171 76, Stockholm, Sweden.

Background: Individuals with Barrett's esophagus (BE) are at increased risk of high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC), but the cost-effectiveness of general surveillance of BE is low. This study aimed to identify a risk prediction model for tumor progression in individuals with BE based on age, sex, and risk factors found at upper endoscopy, enabling tailored surveillance.

Methods: This nested case-control study originated from a cohort of 8171 adults diagnosed with BE in 2006-2013 in the Swedish Patient Registry. Read More

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November 2018
8 Reads

Intestinal metaplasia of the gastric cardia: findings in patients with versus without Barrett's esophagus.

Gastrointest Endosc 2018 Nov 14. Epub 2018 Nov 14.

Division of Gastroenterology, Mayo Clinic Arizona, Scottsdale, Arizona. Electronic address:

Background And Aims: There is controversy about finding intestinal metaplasia (IM) of the gastric cardia on biopsy. The most recent American GI society guideline comments that IM cardia is not more common in patients with Barrett's. It provides limited guidance on whether the cardia should be treated when patients with Barrett's undergo endoscopic eradication therapy (EET) and whether the cardia should be biopsied after ablation. Read More

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November 2018
5 Reads

Radicality of proximal gastrectomy - a rewiev.

Authors:
P Lochman J Páral

Rozhl Chir 2018 ;97(8):360-367

Although the incidence of gastric cancer is decreasing worldwide, the number of esophagogastric junction and upper-third gastric carcinomas is gradually growing. This is due to an increasing incidence of reflux esophagitis with Barrett's metaplasia and successful eradication of Helicobacter pylori infection. Treatment options for these tumors include proximal gastrectomy. Read More

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January 2018
1 Read

Barrett's oesophagus: A qualitative study of patient burden, care delivery experience and follow-up needs.

Health Expect 2018 Nov 14. Epub 2018 Nov 14.

Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester and Manchester Academic Health Sciences Centre, Manchester, UK.

Background: Barrett's oesophagus (BO), a precursor to oesophageal adenocarcinoma, requires long-term endoscopic surveillance. The rising incidence of this chronic disease has implications for service provision and patient burden. Few studies have explored BO patients' personal burden, care delivery experience and participation in health-care delivery decisions. Read More

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November 2018
1 Read
3.410 Impact Factor

Blue-light imaging has an additional value to white-light endoscopy in visualization of early Barrett's neoplasia. an international multicenter cohort study.

Gastrointest Endosc 2018 Nov 9. Epub 2018 Nov 9.

Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Background And Aims: Endoscopic features of early neoplasia in Barrett's esophagus (BE) are subtle. Blue-light imaging (BLI) may improve visualization of neoplastic lesions. The aim of this study was to evaluate BLI in visualization of Barrett's neoplasia. Read More

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November 2018

Concept of histone deacetylases in cancer: Reflections on esophageal carcinogenesis and treatment.

World J Gastroenterol 2018 Nov;24(41):4635-4642

Department of Surgery, Duke University Medical Center, Durham, NC 27710, United States.

Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature. Squamous cell carcinoma is the most common histological type worldwide, though, a continuous increase in esophageal adenocarcinomas has been noted in the past decades. Common risk factors associated with EC include smoking, alcohol consumption, gastroesophageal reflux disease, Barrett's esophagus and obesity. Read More

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November 2018
4 Reads

The Mitochondrial Genes , and are Linked with Alterations in Mitochondrial Membrane Potential in Barrett's Esophagus.

Int J Mol Sci 2018 Nov 6;19(11). Epub 2018 Nov 6.

Trinity Translational Medicine Institute, Department of Surgery, St. James's Hospital, D08W9RT Dublin, Ireland.

Barrett's esophagus and esophageal cancer lack prognostic markers that allow the tailoring of personalized medicine and biomarkers with potential to provide insight into treatment response. This study aims to characterize mitochondrial function across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett's esophagus and examines the functional effect of manipulating mitochondrial genes. Mitochondrial genes of interest were validated in in vitro cell lines across the metaplasia (QH), dysplasia (GO) and adenocarcinoma (OE33) sequence and in in vivo patient tissue samples. Read More

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November 2018

Cancer risk perception in relation to associated symptoms in Barrett's patients: A cross sectional study on quality of life.

United European Gastroenterol J 2018 Nov 7;6(9):1316-1322. Epub 2018 Sep 7.

Department of Gastroenterology and Hepatology, Catharina Hospital, Eindhoven, The Netherlands.

Background: Barrett's oesophagus affects patients' quality of life and may be a psychological burden due to the threat of developing an oesophageal adenocarcinoma.

Objective: Assessing the oesophageal adenocarcinoma risk perceived by non-dysplastic Barrett's oesophagus patients and its association with quality of life, illness perception and reflux symptoms.

Methods: This cross-sectional questionnaire study included 158 Barrett's oesophagus non-dysplastic patients aged 18-75 years. Read More

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November 2018

Endosheath ultrathin transnasal endoscopy is a cost-effective method for screening for Barrett's esophagus in patients with GERD symptoms.

Gastrointest Endosc 2018 Oct 29. Epub 2018 Oct 29.

Department of Gastroenterology and Hepatology, Radboud University Medical Center, Radboud University, Nijmegen, The Netherlands.

Background And Aims: Barrett's esophagus (BE) screening is currently not considered to be cost effective in the general population but may be effective in high-risk subgroups, such as 50-year-old white men with chronic reflux disease (GERD). A new modality for screening is unsedated transnasal endoscopy using endosheath technology (uTNE), which has been shown to be safe and effective in clinical practice. In this study, we determined the cost-utility of uTNE in a high-risk subgroup compared with no screening or screening with standard endoscopy (SE). Read More

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October 2018

Impact of Barrett's esophagus surveillance on the prognosis of esophageal adenocarcinoma: A meta-analysis.

J Dig Dis 2018 Oct 30. Epub 2018 Oct 30.

Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University Medical School, Hangzhou, Zhejiang Province, China.

Objective: Whether endoscopic surveillance would improve the outcomes of esophageal adenocarcinoma in patients diagnosed with Barrett's esophagus previously remained inconsistent. This meta-analysis was performed to assess the survival advantages of endoscopic surveillance for Barrett's esophagus patients.

Methods: Databases including PubMed, Web of Science, and the Cochrane Library were examined systematically from their inception to July 2017, for papers related to the survival outcomes of esophageal adenocarcinoma among patients with Barrett's esophagus under endoscopic surveillance. Read More

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October 2018
6 Reads

Missed Opportunities for Screening and Surveillance of Barrett's Esophagus in Veterans with Esophageal Adenocarcinoma.

Dig Dis Sci 2018 Oct 28. Epub 2018 Oct 28.

Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine Medical Center, McNair Campus, 7200 Cambridge St., 8th Floor, Suite 8B, Houston, TX, 77030, USA.

Background: Barrett's esophagus (BE) is the premalignant lesion of esophageal adenocarcinoma (EAC) and is the target of early detection and prevention efforts for EAC.

Aims: We sought to evaluate what proportion and temporal trends of EAC patients had missed opportunities for screening and surveillance of BE.

Methods: Our study included 182 patients with EAC at the Michael E. Read More

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October 2018

Protective Propensity of Race or Environmental Features in the Development of Barrett's Esophagus in African Americans - A Single Center Pilot Study.

J Natl Med Assoc 2018 Oct 23. Epub 2018 Oct 23.

Division of Gastroenterology, University of Florida/Jacksonville, Jacksonville, FL, USA; Division of Gastroenterology and Hepatology, Augusta University-Medical College of Georgia, Augusta, GA. Electronic address:

Background And Study Aims: Barrett's Esophagus (BE) is a well-recognized pre-malignant condition. Previous data indicate histologically confirmed BE frequency varies by ethnicity in the United States. However, clinical factor assessment to explain this has only occurred in a veteran population to date. Read More

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October 2018
4 Reads

Introduction of endoscopic submucosal dissection in the West.

World J Gastrointest Endosc 2018 Oct;10(10):225-238

Gastroenterology, NYU Winthrop Hospital, Mineola, NY 11501, United States.

Endoscopic submucosal dissection (ESD) is well established in Asia as a modality for selected advanced lesions of both the upper and lower gastrointestinal tract, but ESD has not attained the same niche in the West due to a variety of reasons. These include competition from traditional surgery, minimally invasive surgery and endoscopic mucosal resection. Other obstacles to ESD introduction in the West include time commitment for learning and doing procedures, a steep learning curve, special equipment, lack of mentors, cost issues, interdisciplinary conflicts, concern regarding complications and lack of support from institutions and interfacing departments. Read More

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October 2018
3 Reads

Precision care for Barrett's esophagus.

Transl Gastroenterol Hepatol 2018 17;3:67. Epub 2018 Sep 17.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.

Modern recognition and management of Barrett's esophagus, a precursor to esophageal adenocarcinoma depends on diagnostic accuracy, risk assessment, technical expertise and consideration of many options to best tailor therapy for every patient. Concomitant management of acid reflux is essential, frequently with proton pump inhibitors. Ablation and resection favorably affect the evolution towards cancer. Read More

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September 2018
7 Reads

2017 David Sun Lecture: Screening and Surveillance of Barrett's Esophagus: Where Are We Now and What Does the Future Hold?

Authors:
Gary W Falk

Am J Gastroenterol 2018 Oct 25. Epub 2018 Oct 25.

Division of Gastroenterology Department of Medicine Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Barrett's esophagus and esophageal adenocarcinoma continue to present considerable management challenges in the Western world. Despite our best efforts to date, the prognosis of advanced esophageal adenocarcinoma remains poor and far too many individuals with esophageal adenocarcinoma have not had a prior endoscopy to detect Barrett's esophagus. As such, current strategies of screening for Barrett's esophagus and subsequent surveillance need to be further optimized. Read More

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October 2018

Efficacy and safety of radiofrequency ablation of Barrett's esophagus in the absence of reimbursement: a multicenter prospective Belgian registry.

Endoscopy 2018 Oct 25. Epub 2018 Oct 25.

Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Belgium.

Background:  Radiofrequency ablation (RFA), combined with endoscopic resection, can be used as a primary treatment for low grade dysplasia, high grade dysplasia, and early esophageal adenocarcinoma (EAC) in Barrett's esophagus (BE). The aim of the Belgian RFA registry is to capture the real-life outcome of endoscopic therapy for BE with RFA and to assess efficacy and safety outside study protocols, in the absence of reimbursement.

Patients And Methods:  Between February 2008 and January 2017, data from 7 different expert centers were prospectively collected in the registry. Read More

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October 2018

Barrett's esophagus with high grade dysplasia is associated with non-esophageal cancer.

World J Gastroenterol 2018 Oct;24(39):4472-4481

Department of Gastroenterology, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.

Aim: To study factors associated with esophageal and non-esophageal cancer morbidity among Barrett's esophagus (BE) patients.

Methods: A cohort study within a single tertiary center included 386 consecutive patients with biopsy proven BE, who were recruited between 2004-2014. Endoscopic and histologic data were prospectively recorded. Read More

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October 2018
5 Reads

Biomarkers for Barrett's esophagus - a contemporary review.

Expert Rev Mol Diagn 2018 Nov 1;18(11):939-946. Epub 2018 Nov 1.

b Department of Pathology, Harvard Medical School , Brigham and Women's Hospital , Boston , MA.

Introduction: Esophageal adenocarcinoma (EAC) has a poor 5-year survival rate (10%-18%), and incidence has increased dramatically in the past three decades. Barrett's esophagus (BE) is the precursor lesion to EAC and is the replacement of the normally squamous lined esophagus with columnar cells that develop an intestinal phenotype characterized by the presence of goblet cells. Given the known precursor state, EAC is amenable to screening and surveillance strategies (analogous to colon cancer). Read More

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November 2018
6 Reads

An improved surgical procedure to establish a gastroesophageal reflux model with a high incidence of Barrett's esophagus in rats.

Exp Ther Med 2018 Nov 10;16(5):3863-3868. Epub 2018 Sep 10.

Department of Gastroenterology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442002, P.R. China.

Barrett's esophagus (BE) is a complication of gastroesophageal reflux disease and is a precursor lesion of esophageal adenocarcinoma. In existing BE models, the incidence of BE is typically low and induction is usually time consuming. In the present study, a gastroesophageal reflux model with a high incidence of BE in rats. Read More

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November 2018
4 Reads
0.940 Impact Factor

Esophageal adenocarcinoma in Barrett's esophagus after sleeve gastrectomy: Case report and literature review.

Int J Surg Case Rep 2018 12;52:132-136. Epub 2018 Oct 12.

Department of Digestive Surgery, Centre Hospitalier de Saint-Denis, 2 Rue du Docteur Delafontaine, 93205, Saint-Denis, France. Electronic address:

Introduction: Sleeve gastrectomy (SG) has become one of the most dramatically increasing bariatric procedures worldwide due to its excellent results and impact on the obesity pandemic. Morbid obesity is known to increase the risk of esophageal adenocarcinoma. However, the evolution of gastroesophageal reflux disease (GERD) along with Barrett's esophagus (BE) after SG is of concern since there is little data available. Read More

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October 2018
6 Reads

Increasing prevalence of high-grade dysplasia and adenocarcinoma on index endoscopy in Barrett's esophagus over the past 2 decades: data from a multicenter U.S. consortium.

Gastrointest Endosc 2018 Oct 17. Epub 2018 Oct 17.

Gastroenterology and Hepatology, University of Kansas Medical Center, Kansas City, KS, United States; Gastroenterology, VA medical center Kansas City, Kansas City, MO, United States. Electronic address:

Introduction: Data on time trends of dysplasia and esophageal adenocarcinoma (EAC) in Barrett's esophagus (BE) during the index endoscopy (ie, prevalent cases) are limited. Our aim was to determine the prevalence patterns of BE associated dysplasia on index endoscopy over the past 25 years.

Methods: The Barrett's esophagus study is a multicenter outcome project of a large cohort of BE patients. Read More

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October 2018

Inflammation and cancer.

Authors:
Mariko Murata

Environ Health Prev Med 2018 Oct 20;23(1):50. Epub 2018 Oct 20.

Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Infection and inflammation account for approximately 25% of cancer-causing factors. Inflammation-related cancers are characterized by mutagenic DNA lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-nitroguanine. Our previous studies demonstrated the formation of 8-oxodG and 8-nitroguanine in the tissues of cancer and precancerous lesions due to infection (e. Read More

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October 2018
1 Read

Outcome of endoscopic mucosal resection in Barrett's esophagus determined by systematic quantification of epithelial glands using volumetric laser endomicroscopy.

Gastrointest Endosc 2018 Oct 16. Epub 2018 Oct 16.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN. Electronic address:

Background: Dysplastic Barrett's esophagus (BE) lesions ≤2 cm in size can be targeted for en-bloc endoscopic mucosal resection (EMR). White-light endoscopy can underestimate the size of a lesion, limiting complete resection. Volumetric laser endomicroscopy (VLE) provides high-resolution cross-sectional imaging of BE. Read More

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October 2018

The Best Surveillance Intervals for Detection of Intestinal Metaplasia and Dysplasia after Successful Endoscopic Eradication Therapy of Barrett's Esophagus.

Am J Gastroenterol 2018 Oct 18. Epub 2018 Oct 18.

The Hand Surgery Research Center, Affiliated Hospital of Nantong University, Medical School of Nantong University, 226001, Nantong, China.

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October 2018
7 Reads
10.760 Impact Factor

DNA Methylation Biomarkers for the Diagnosis of Barrett's Oesophagus.

Am J Gastroenterol 2018 Nov 17;113(11):1722. Epub 2018 Oct 17.

MRC Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Cambridge, UK.

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November 2018
14 Reads

Helicobacter pylori Infection and Gastroesophageal Reflux Disease-Barrett's Esophagus-Esophageal Adenocarcinoma Sequence: Reply From Authors.

Am J Gastroenterol 2018 Nov 17;113(11):1724-1725. Epub 2018 Oct 17.

Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

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November 2018
1 Read

Barrett's esophagus is negatively associated with eosinophilic esophagitis in Japanese subjects.

Esophagus 2018 Oct 16. Epub 2018 Oct 16.

Department of Gastroenterology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.

Background: Although both eosinophilic esophagitis (EoE) and Barrett's esophagus (BE) are considered to be associated with T helper (Th) 2-mediated immune responses, the association between EoE and BE is unclear. We investigated the clinical relationship between EoE and BE.

Methods: We conducted a single-center retrospective observational study. Read More

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October 2018
2 Reads

Single cell RNA-seq reveals profound transcriptional similarity between Barrett's oesophagus and oesophageal submucosal glands.

Nat Commun 2018 10 15;9(1):4261. Epub 2018 Oct 15.

Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.

Barrett's oesophagus is a precursor of oesophageal adenocarcinoma. In this common condition, squamous epithelium in the oesophagus is replaced by columnar epithelium in response to acid reflux. Barrett's oesophagus is highly heterogeneous and its relationships to normal tissues are unclear. Read More

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October 2018
14 Reads

Minute adenocarcinoma on Barrett's esophagus: the importance of directed biopsy sampling.

Rev Esp Enferm Dig 2018 Oct 15;111. Epub 2018 Oct 15.

Aparato Digestivo, Hospìtal Universitario Santa Lucía, ESPAÑA.

Patients with Barrett's esophagus (BE) have a risk of esophageal cancer thirty times higher than the general population. The grade of dysplasia must be established during endoscopic follow-up. The effectiveness of endoscopic surveillance programs for the diagnosis of advanced esophageal adenocarcinoma has been questioned. Read More

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October 2018
4 Reads

Prevalence of esophageal inlet patch and clinical characteristics of the patients.

Rev Gastroenterol Mex 2018 Oct 11. Epub 2018 Oct 11.

Dirección de Educación e Investigación en Salud, UMAE Hospital de Especialidades del Centro Médico Nacional Manuel Ávila Camacho, Instituto Mexicano del Seguro Social, Puebla, Pue, México.

Introduction And Aims: An inlet patch (IP) is the presence of gastric columnar epithelium outside of the stomach. No studies have been conducted in Mexico on that pathology. The aim of the present study was to determine the prevalence of esophageal IP and the clinical characteristics of the patients that present it. Read More

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October 2018

Reply to the Letter to the Editor "Does Sleeve Gastrectomy Cause Barrett's Oesophagus?"

Obes Surg 2018 Dec;28(12):4051-4052

Division of General Surgery, Department of Surgery, Vienna Medical University, Währinger Guertel 18-20, 1090, Vienna, Austria.

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December 2018

Sound the Alarm for Barrett's Screening!

Clin Gastroenterol Hepatol 2018 Oct 10. Epub 2018 Oct 10.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

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October 2018
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