1,052 results match your criteria Barrett's Esophagus Imaging

Diagnostic Accuracy of Narrow Band Imaging Endoscopy with targeted biopsies compared to Standard Endoscopy with Random Biopsies in Patients with Barrett's Esophagus: A Systematic Review and Meta-analysis.

J Gastroenterol Hepatol 2021 Jun 13. Epub 2021 Jun 13.

Dept of Gastroenterology, The Lyell McEwin Hospital, South Australia, Australia.

Background: Endoscopic surveillance for dysplasia in Barrett's esophagus with random biopsies is the primary diagnostic tool for monitoring clinical progression into esophageal adenocarcinoma. As an alternative, narrow-band imaging (NBI) endoscopy offers targeted biopsies that can improve dysplasia detection.

Aim: To evaluate NBI-guided targeted biopsies' diagnostic accuracy for detecting dysplasia in patients undergoing endoscopic BE surveillance compared to the widely used Seattle protocol. Read More

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A pilot study on automatic 3D quantification of Barrett's esophagus for risk stratification and therapy monitoring.

Gastroenterology 2021 Jun 8. Epub 2021 Jun 8.

Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Div., John Radcliffe Hospital, University of Oxford, Oxford, UK;; Oxford NIHR Biomedical Research Centre, Oxford, UK;. Electronic address:

Background Aims: Barrett's epithelium measurement using widely accepted Prague C&M classification is highly operator dependent. We propose a novel methodology for measuring this risk score automatically. The method also enables quantification of the area of Barrett's epithelium (BEA) and islands which was not possible before. Read More

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Diagnostic utility of a novel magnifying endoscopic classification system for superficial Barrett's esophagus-related neoplasms: a nationwide multicenter study.

Esophagus 2021 May 30. Epub 2021 May 30.

Department of Endoscopy, Saku Central Hospital Advanced Care Center, Nagano, Japan.

Background: Currently, no classification system using magnification endoscopy for the diagnosis of superficial Barrett's esophagus (BE)-related neoplasia has been widely accepted. This nationwide multicenter study aimed to validate the diagnostic accuracy and reproducibility of the magnification endoscopy classification system, including the diagnostic flowchart developed by the Japan Esophageal Society-Barrett's esophagus working group (JES-BE) for superficial Barrett's esophagus-related neoplasms.

Methods: The JES-BE acquired high-definition magnification narrow-band imaging (HM-NBI) images of non-dysplastic and dysplastic BE from 10 domestic institutions. Read More

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Proc IEEE Int Symp Biomed Imaging 2020 Apr 22;2020:1659-1663. Epub 2020 May 22.

University of Virginia, Engineering Systems and Environment, Charlottesville, VA.

Histologic diagnosis of Barrett's esophagus and esophageal malignancy via probe-based confocal laser endomicroscopy (pCLE) allows for real-time examination of epithelial architecture and targeted biopsy sampling. Although pCLE demonstrates high specificity, sensitivity remains low. This study employs deep learning architectures in order to improve the accuracy of pCLE in diagnosing esophageal cancer and its precursors. Read More

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Spectral Endoscopy Enhances Contrast for Neoplasia in Surveillance of Barrett's Esophagus.

Cancer Res 2021 May 26. Epub 2021 May 26.

Department of Physics and Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.

Early detection of esophageal neoplasia enables curative endoscopic therapy, but the current diagnostic standard of care has low sensitivity because early neoplasia is often inconspicuous with conventional white-light endoscopy. Here, we hypothesized that spectral endoscopy could enhance contrast for neoplasia in surveillance of patients with Barrett's esophagus. A custom spectral endoscope was deployed in a pilot clinical study of 20 patients to capture 715 tissue spectra matched with gold standard diagnosis from histopathology. Read More

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Probe-based confocal laser endomicroscopy and Barrett's esophagus - just a scientific toy or significant improvement in diagnosis?

Dig Dis 2021 Apr 1. Epub 2021 Apr 1.

Background: Barrett's esophagus (BE) requires surveillance to identify potential neoplasia at early stage. Standard surveillance regimen includes random four-quadrant biopsies by Seattle protocol. Main limitations of random biopsies are high risk of sampling error, difficulties in histology interpretation, common inadequate classification of pathohistological changes, increased risk of bleeding and time necessary to acquire the final diagnosis. Read More

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Prevalence and Clinical and Endoscopic Characteristics of Cervical Inlet Patch (Heterotopic Gastric Mucosa): A Systematic Review and Meta-Analysis.

J Clin Gastroenterol 2021 Mar 12. Epub 2021 Mar 12.

*Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang †Postgraduate College, Jinzhou Medical University, Jinzhou §Postgraduate College, Dalian Medical University, Dalian, People's Republic of China ‡Department of Medicine, Division of Gastroenterology, Vancouver General Hospital, Vancouver, Canada.

Background: Cervical inlet patch (CIP), also called gastric inlet patch, is a heterotopic columnar mucosal island located in the cervical esophagus, which has been under-recognized by clinicians.

Aim: We conducted a systemic review and meta-analysis to explore the prevalence and clinical and endoscopic characteristics of CIP.

Materials And Methods: Studies were searched through the PubMed, EMBASE, and Cochrane Library databases. Read More

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What is the optimal surveillance strategy for non-dysplastic Barrett's esophagus?

Curr Treat Options Gastroenterol 2020 Sep 25;18(3):369-383. Epub 2020 Jun 25.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Purpose Of Review: There is conflicting data on the effectiveness of the currently recommended endoscopic surveillance strategy in non-dysplastic BE patients. We reviewed the literature to evaluate the (cost) effectiveness of the current surveillance strategy. We also reviewed critical strategies and new technologies which could improve dysplasia detection. Read More

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September 2020

Longitudinal and Circumferential Distributions of Dysplasia and Early Neoplasia in Barrett's Esophagus: A Pooled Analysis of Three Prospective Studies.

Clin Transl Gastroenterol 2021 Feb 22;12(2):e00311. Epub 2021 Feb 22.

Division of Gastroenterology, Long Island Jewish Medical Center, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, New Hyde Park, New York, USA.

Introduction: Studies have shown that dysplasia in Barrett's esophagus (BE) has a predilection for the right hemisphere. There is limited information on the longitudinal distribution. The aim was to determine both the longitudinal and circumferential distributions of dysplasia and early neoplasia from 3 prospective studies. Read More

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February 2021

Feasibility and Safety of Tethered Capsule Endomicroscopy in Patients With Barrett's Esophagus in a Multi-Center Study.

Clin Gastroenterol Hepatol 2021 Feb 4. Epub 2021 Feb 4.

Columbia University Irving Medical Center, New York, New York.

Background & Aims: Tethered capsule endomicroscopy (TCE) involves swallowing a small tethered pill that implements optical coherence tomography (OCT) imaging, procuring high resolution images of the whole esophagus. Here, we demonstrate and evaluate the feasibility and safety of TCE and a portable OCT imaging system in patients with Barrett's esophagus (BE) in a multi-center (5-site) clinical study.

Methods: Untreated patients with BE as per endoscopic biopsy diagnosis were eligible to participate in the study. Read More

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February 2021

Endoscopic retrieval for a large impacted meat bolus in the oesophagus.

BMJ Case Rep 2021 Feb 4;14(2). Epub 2021 Feb 4.

Department of Internal Medicine, Division of Gastroenterology, Inje University Sanggye Paik Hospital, Nowon-gu, Korea (the Republic of)

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February 2021

Hepatocellular carcinoma masquerading as nodular Barrett's esophagus.

Gastrointest Endosc 2021 May 22;93(5):1182-1183. Epub 2021 Jan 22.

Division of Gastroenterology, Hepatology and Nutrition, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.

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Tropism of Severe Acute Respiratory Syndrome Coronavirus 2 for Barrett's Esophagus May Increase Susceptibility to Developing Coronavirus Disease 2019.

Gastroenterology 2021 05 20;160(6):2165-2168.e4. Epub 2021 Jan 20.

Division of Gastroenterology, Department of Medicine, Washington University in St Louis, School of Medicine, St Louis, Missouri; Department of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, Missouri; Department of Developmental Biology, Washington University in St Louis, School of Medicine, St Louis, Missouri. Electronic address:

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Barrett's esophagus: current standards in advanced imaging.

Transl Gastroenterol Hepatol 2021 5;6:14. Epub 2021 Jan 5.

Division of Gastroenterology & Hepatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Esophageal adenocarcinoma (EAC) continues to be one of the fastest rising incident cancers in the Western population with the majority of patients presenting with late stage disease and associated with a dismal 5-year survival rate. Barrett's esophagus (BE) is the only identifiable precursor lesion to EAC. Strategies to screen for and survey BE are critical to detect earlier cancers and reduce morbidity and mortality related to EAC. Read More

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January 2021

Endoscopic features of buried Barrett's mucosa.

Gastrointest Endosc 2021 Jul 26;94(1):14-21. Epub 2020 Dec 26.

Department of Gastroenterology, St Vincent's Hospital Melbourne and the University of Melbourne, Melbourne, Australia.

Background And Aims: Buried Barrett's mucosa is defined as intestinal metaplasia that is "buried" under the normal-appearing squamous epithelium. This can occur in Barrett's esophagus with or without previous endoscopic therapy. Dysplasia and neoplasia within buried Barrett's mucosa have also been reported. Read More

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Helicobacter pylori and Upper Endoscopy in Systemic Sclerosis: A Cross-sectional Study in the Real World.

J Clin Rheumatol 2021 Jan;27(1):40-41

Department of Clinical, Internal, Anaesthesiologic, Cardiologic Sciences, University of Rome Sapienza, Rome, Italy.

Background/aims: A role for Helicobacter pylori in triggering systemic sclerosis (SSc) has been proposed, but data are conflicting. In previous studies, infection has been generally searched for by using serology. We designed this study to assess H. Read More

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January 2021

Artificial intelligence in gastrointestinal endoscopy.

VideoGIE 2020 Dec 9;5(12):598-613. Epub 2020 Nov 9.

Division of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts.

Background And Aims: Artificial intelligence (AI)-based applications have transformed several industries and are widely used in various consumer products and services. In medicine, AI is primarily being used for image classification and natural language processing and has great potential to affect image-based specialties such as radiology, pathology, and gastroenterology (GE). This document reviews the reported applications of AI in GE, focusing on endoscopic image analysis. Read More

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December 2020

Giant hiatus hernia presenting as a chronic cough masking a sinister diagnosis.

BMJ Case Rep 2020 Dec 10;13(12). Epub 2020 Dec 10.

General Surgery, Queen's Hospital, Romford, London, UK.

We present a case of an 82-year-old gentleman with an 18-month history of productive cough. Urgent CT scan of the thorax revealed type 1 hiatus hernia (HH). The patient was managed conservatively with lifestyle modifications to help his reflux symptomology. Read More

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December 2020

Barrett's Esophageal Adenocarcinoma Involving a White Globe Appearance within the Long-Segment Barrett's Esophagus.

Case Rep Gastroenterol 2020 Sep-Dec;14(3):510-515. Epub 2020 Oct 22.

Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan.

The diagnosis of Barrett's esophageal adenocarcinoma (BEA) in patients with Barrett's esophagus (BE) using endoscopy can be difficult and there are few specific endoscopic findings for BEA. However, white globe appearance (WGA) has been reported to be a specific endoscopic finding for early gastric cancer. We encountered a 51-year-old male patient with BEA exhibiting WGA. Read More

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October 2020

Advanced Imaging and Sampling in Barrett's Esophagus: Artificial Intelligence to the Rescue?

Gastrointest Endosc Clin N Am 2021 Jan 26;31(1):91-103. Epub 2020 Oct 26.

Department of Gastroenterology and Hepatology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, the Netherlands. Electronic address:

Because the current Barrett's esophagus (BE) surveillance protocol suffers from sampling error of random biopsies and a high miss-rate of early neoplastic lesions, many new endoscopic imaging and sampling techniques have been developed. None of these techniques, however, have significantly increased the diagnostic yield of BE neoplasia. In fact, these techniques have led to an increase in the amount of visible information, yet endoscopists and pathologists inevitably suffer from variations in intra- and interobserver agreement. Read More

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January 2021

Progress in Screening for Barrett's Esophagus: Beyond Standard Upper Endoscopy.

Gastrointest Endosc Clin N Am 2021 Jan;31(1):43-58

MRC Cancer Unit, University of Cambridge, Cambridge Biomedical Campus, Box 197, Cambridge CB2 0XZ, United Kingdom; Addenbrookes Hospital, Cambridge University NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, United Kingdom. Electronic address:

The rapid increase in the incidence of esophageal adenocarcinoma in Western populations over the past 4 decades and its associated poor prognosis, unless detected early has generated great interest in screening for the precursor lesion Barrett's esophagus (BE). Recently, there have been significant developments in imaging-based modalities and esophageal cell-sampling devices coupled with biomarker assays. In this review, the authors discuss the rationale for screening for BE and the factors to consider for targeting the at-risk population. Read More

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January 2021

Advanced endoscopic imaging for detecting and guiding therapy of early neoplasias of the esophagus.

Ann N Y Acad Sci 2020 12 12;1482(1):61-76. Epub 2020 Nov 12.

VA Boston Healthcare System, Boston, Massachusetts.

Esophageal cancers, largely adenocarcinoma in Western countries and squamous cell cancer in Asia, present a significant burden of disease and remain one of the most lethal of cancers. Key to improving survival is the development and adoption of new imaging modalities to identify early neoplastic lesions, which may be small, multifocal, subsurface, and difficult to detect by standard endoscopy. Such advanced imaging is particularly relevant with the emergence of ablative techniques that often require multiple endoscopic sessions and may be complicated by bleeding, pain, strictures, and recurrences. Read More

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December 2020

Moxifloxacin based fluorescence imaging of intestinal goblet cells.

Biomed Opt Express 2020 Oct 23;11(10):5814-5825. Epub 2020 Sep 23.

Department of Mechanical Engineering, Pohang University of Science and Technology, 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, South Korea.

Goblet cells (GCs) in the intestine are specialized epithelial cells that secrete mucins to form the protective mucous layer. GCs are important in maintaining intestinal homeostasis, and the alteration of GCs is observed in inflammatory bowel diseases (IBDs) and neoplastic lesions. In the Barrett's esophagus, the presence of GCs is used as a marker of specialized intestinal metaplasia. Read More

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October 2020

Role of artificial intelligence in the diagnosis of oesophageal neoplasia: 2020 an endoscopic odyssey.

World J Gastroenterol 2020 Oct;26(38):5784-5796

Department of GI Services, University College London Hospital, London NW1 2BU, United Kingdom.

The past decade has seen significant advances in endoscopic imaging and optical enhancements to aid early diagnosis. There is still a treatment gap due to the underdiagnosis of lesions of the oesophagus. Computer aided diagnosis may play an important role in the coming years in providing an adjunct to endoscopists in the early detection and diagnosis of early oesophageal cancers, therefore curative endoscopic therapy can be offered. Read More

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October 2020

Linked color imaging improves visibility of reflux esophagitis.

BMC Gastroenterol 2020 Oct 27;20(1):356. Epub 2020 Oct 27.

Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: With more prevalent gastroesophageal reflux disease comes increased cases of Barrett's esophagus and esophageal adenocarcinoma. Image-enhanced endoscopy using linked-color imaging (LCI) differentiates between mucosal colors. We compared LCI, white light imaging (WLI), and blue LASER imaging (BLI) in diagnosing reflux esophagitis (RE). Read More

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October 2020

Is Malignant Potential of Barrett's Esophagus Predictable by Endoscopy Findings?

Life (Basel) 2020 Oct 16;10(10). Epub 2020 Oct 16.

Department of Internal Medicine II, Faculty of Medicine, Shimane University, Shimane 693-8501, Japan.

Given that endoscopic findings can be used to predict the potential of neoplastic progression in Barrett's esophagus (BE) cases, the detection rate of dysplastic Barrett's lesions may become higher even in laborious endoscopic surveillance because a special attention is consequently paid. However, endoscopic findings for effective detection of the risk of neoplastic progression to esophageal adenocarcinoma (EAC) have not been confirmed, though some typical appearances are suggestive. In the present review, endoscopic findings that can be used predict malignant potential to EAC in BE cases are discussed. Read More

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October 2020

The Efficacy of Linked Color Imaging in the Endoscopic Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma.

Gastroenterol Res Pract 2020 29;2020:9604345. Epub 2020 Sep 29.

Department of Gastroenterology, Graduate School of Medicine, Chiba University Chiba, Japan.

Background: The present study aimed to evaluate the efficacy of linked color imaging (LCI) in diagnosing Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC).

Methods: A total of 112 and 12 consecutive patients with BE and EAC were analyzed. The visibility scores of BE and EAC ranging from 4 (excellent visibility) to 0 (not detectable) were evaluated by three trainees and three experts using white light imaging (WLI), LCI mode, and blue laser imaging bright (BLI-b) mode. Read More

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September 2020

Assisting Barrett's esophagus identification using endoscopic data augmentation based on Generative Adversarial Networks.

Comput Biol Med 2020 11 10;126:104029. Epub 2020 Oct 10.

Department of Computing, São Paulo State University, UNESP, Brazil. Electronic address:

Barrett's esophagus figured a swift rise in the number of cases in the past years. Although traditional diagnosis methods offered a vital role in early-stage treatment, they are generally time- and resource-consuming. In this context, computer-aided approaches for automatic diagnosis emerged in the literature since early detection is intrinsically related to remission probabilities. Read More

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November 2020

Artificial Intelligence and Its Role in Identifying Esophageal Neoplasia.

Dig Dis Sci 2020 12 15;65(12):3448-3455. Epub 2020 Oct 15.

Division of Gastroenterology, Virginia Commonwealth University Health System, 1200 East Marshall St, PO Box 980711, Richmond, VA, 23298, USA.

Randomized trials have demonstrated that ablation of dysplastic Barrett's esophagus can reduce the risk of progression to cancer. Endoscopic resection for early stage esophageal adenocarcinoma and squamous cell carcinoma can significantly reduce postoperative morbidity compared to esophagectomy. Unfortunately, current endoscopic surveillance technologies (e. Read More

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December 2020

An esophageal neuroendocrine tumor in a Barrett's esophagus successfully treated with endoscopic resection.

Rev Esp Enferm Dig 2020 Nov;112(11):885-886

Aparato Digestivo, Hospital Universitario Virgen Macarena, España.

Neuroendocrine tumors rarely occur in the esophagus because the neuroendocrine system is not well developed in the esophagus. The case of a neuroendocrine esophageal tumor developed in a patient with Barret's esophagus is presented. It was successfully trated by endoscopy. Read More

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November 2020