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Obes Rev 2020 Jun 4. Epub 2020 Jun 4.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

Health state utilities (HSUs) are health economic metrics that capture and assess health-related quality of life (HRQoL). They are essential in health-economic evaluations when calculating quality-adjusted life years. We investigated published studies reporting bariatric surgery-related HSUs elicited through direct or indirect (multiattribute utility instrument [MAUI]) patient-reported methods (PROSPERO registration number: CRD42019131725). Read More

Br J Surg 2020 Jun 4. Epub 2020 Jun 4.

Department of Surgery, Örebro University Faculty of Medicine and Health, Unversity Hospital, Örebro, Sweden.

Br J Surg 2020 Jun 4. Epub 2020 Jun 4.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Surg Laparosc Endosc Percutan Tech 2020 Jun 2. Epub 2020 Jun 2.

Department of Bariatric Surgery, Orlando Regional Medical Center, Orlando Health, Orlando, FL.

Background: One of the most significant concerns after laparoscopic sleeve gastrectomy (LSG) is the new-onset or worsening of gastroesophageal reflux disease (GERD). Some patients with LSG undergo a conversion to Roux-en-Y gastric bypass (RYGB) because of severe GERD. Cardiopexy at the time of LSG may help prevent GERD. Read More

Curr Obes Rep 2020 Jun 3. Epub 2020 Jun 3.

Department of Gastroenterology, Mayo Clinic Rochester, Rochester, MA, USA.

Purpose Of Review: In the treatment of epidemic obesity and metabolic disorders, conservative approaches often fail to achieve the treatment goal in patients with very high BMI. To date, bariatric surgery accomplishes the most sustainable results in patients with morbid obesity. This leads to a treatment gap for lower and middle classes of obesity defined by BMI. Read More

Obes Surg 2020 Jun 4. Epub 2020 Jun 4.

General and Oncologic Surgery Department, Centre of Advanced Laparoscopic Surgery, Centre of Bariatric Surgery - San Marco Hospital GSD, Corso Europa, 7, 24040, Zingonia, BG, Italy.

Purpose: To analyze the safety of laparoscopic ventral hernia delayed repair in bariatric patients with a composite mesh.

Materials And Methods: This retrospective single-center observational trial analyzed all bariatric/obese patients with concomitant ventral hernia who underwent laparoscopic abdominal hernia repair before bariatric surgery (group A) and laparoscopic delayed repair after weight loss obtained by the bariatric procedure (group B).

Results: Group A (30 patients) had a mean BMI of 37. Read More

Obes Surg 2020 Jun 3. Epub 2020 Jun 3.

Service of Bariatric and Metabolic Surgery, Indisa Clinic, Avenida Santa María 1810, 7520440, Santiago, Chile.

Purpose: After laparoscopic sleeve gastrectomy (LSG), several studies have reported an increase in the incidence of gastroesophageal reflux (GERD). The etiopathogenesis of GERD post-LSG is multifactorial, and hiatal hernia (HH) is one of them. The primary objective was to measure the incidence of de novo HH post-LSG. Read More

Obes Surg 2020 Jun 3. Epub 2020 Jun 3.

General Surgery Department, Mansoura University Hospitals, Mansoura University, Elgomhuoria Street, Mansoura City, Egypt.

Purpose: Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric procedure, yet can be followed by complications such as staple line leak and bleeding, vomiting, and gastroesophageal reflux disease (GERD). Various attempts have been described in the literature to improve the early outcome of LSG through various measures. This study aimed to assess the impact of adding T-shaped omentoplasty to LSG on the short-term outcome of the procedure. Read More

Obes Surg 2020 Jun 3. Epub 2020 Jun 3.

General Surgery Department, Endocrine and Bariatric Surgery Division, Clinic University Hospital of Valencia, University of Valencia, Av. de Blasco Ibáñez, 17, 46010, Valencia, Spain.

The references were incorrectly ordered during production. Read More

Obes Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of General Surgery, Geisinger Medical Center, 100 N. Academy Avenue, MC 21-69, Danville, PA, 17822, USA.

Background: The objective of this study was to examine the MBSAQIP database to assess efficiency trends and perioperative outcomes in robotic bariatric surgery.

Methods: Robotic (RA) and laparoscopic (L) sleeve gastrectomy (SG) and gastric bypass (RYGB) were compared using the 2015-2018 MBSAQIP Participant Use Data Files. Patients were propensity matched 1:1 based on sex, body mass index, assistant, and previous obesity or foregut surgery. Read More

Obes Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Mechanical and Aerospace Engineering, Brunel University London, Kingston Lane, Uxbridge, Middlesex, UB8 3PH, UK.

Purpose: Obesity clearly increases cardiovascular risk, often inducing high blood pressure (BP), impaired left ventricular (LV) function, and increased arterial stiffness. Intensive weight loss and bariatric surgery induce improvement in hypertension and diabetes for morbid obesity. Carotid artery haemodynamics is a powerful prognostic indicator for stroke and cognitive decline independent of BP. Read More

BMC Surg 2020 Jun 3;20(1):117. Epub 2020 Jun 3.

Obesity Center Máxima - Máxima Medical Center, Eindhoven/Veldhoven, The Netherlands.

Background: Recent data support the use of bariatric surgery in adolescents with severe obesity following unsuccessful non-surgical treatments. Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) have demonstrated reasonably similar weight loss and reduction of obesity related comorbidities in randomized trials in adults. SG has internationally become the most commonly used procedure in adolescents, yet long-term outcome data are lacking. Read More

Obes Facts 2020 Jun 3:1-8. Epub 2020 Jun 3.

Department of General and Digestive Surgery, Hospital Clinico Universitario, Valencia, Spain,

Introduction: Revisional surgery must be considered when insufficient weight loss is attained or weight is subsequently regained. This study aimed to investigate the value of Roux-en-Y gastric bypass (RYGB) as a revisional procedure after restrictive surgery.

Materials And Methods: An observational, retrospective study including patients initially operated on for morbid obesity with restrictive techniques (vertical-banded gastroplasty [VBG], adjustable gastric band [AGB], and sleeve gastrectomy) and reoperated with RYGB in our centre between December 1994 and January 2019. Read More

Med Hypotheses 2020 May 27;143:109883. Epub 2020 May 27.

President British Obesity and Metabolic Surgery Society, Visiting Professor University of Chester, CEO Phoenix Health, United Kingdom. Electronic address:

It is widely believed that infection with the SARS-CoV-2 virus triggers a disproportionate immune response which causes a devastating systemic injury, particularly in individuals with obesity, itself a chronic, multi-organ inflammatory disease. Immune cells accumulate in visceral adipose tissue and together with paracrine adipocytes release a wide range of biologically active cytokines (including IL-1β, IL5, IL6 and IL8) that can result in both local, pulmonary and systemic inflammation. A more intense 'cytokine storm' is postulated as the mechanism behind the extreme immune response seen in severe COVID-19. Read More

J Clin Ultrasound 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Purpose: To evaluate technical and patient-related factors that can affect the reliability of acoustic radiation force impulse shear wave elastography (ARFI-SWE) in morbidly obese patients.

Methods: A prospective single-center study was performed on 41 patients (32 females, 78%) presenting for preoperative evaluation for bariatric surgery. ARFI-SWE was performed using a 6 to 1. Read More

Wideochir Inne Tech Maloinwazyjne 2020 Jun 16;15(2):290-297. Epub 2019 Nov 16.

Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Roux-en-Y gastric bypass (RYGB) is one of the safe and easily reproducible bariatric procedures.

Aim: To evaluate the effect of biliopancreatic limb (BPL) and alimentary limb (AL) length on weight loss outcomes after RYGB.

Material And Methods: This retrospective cohort study included 313 morbidly obese patients who underwent primary laparoscopic RYGB 2009-2015. Read More

Wideochir Inne Tech Maloinwazyjne 2020 Jun 29;15(2):249-267. Epub 2019 Oct 29.

2 Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.

Introduction: Sleeve gastrectomy (SG) is one of the most popular bariatric operations and one of the most frequently studied areas in bariatric surgery.

Aim: To summarise the characteristics of the most frequently cited studies focusing on SG.

Material And Methods: We used the Web of Science database to identify all studies focused on SG published from 2000 to 2018. Read More

Obes Surg 2020 Jun 2. Epub 2020 Jun 2.

Department of Medicine, Surgery, and Dentistry, "Scuola Medica Salernitana", University of Salerno, Fisciano, Italy.

Background: To assess dietary habits in a cohort of patients at minimum follow-up of 4 years after sleeve gastrectomy (SG) by comparing their dietary records to the Italian Mediterranean diet (IMD) recommendations.

Methods: We prospectively evaluated in 74 patients who had the SG in 2014 dietary habits by a 7-day food dietary records, weight and micronutrient status, evolution of comorbidities, use of micronutrient supplements, and frequency of physical activity.

Results: The IMD recommendations in terms of daily/weekly portions of fruits, vegetables, and complex carbohydrates were followed by 40. Read More

Obes Surg 2020 Jun 2. Epub 2020 Jun 2.

Digestive Surgery and Liver Transplantation Unit, Centre Hospitalier Universitaire de Nice, Archet II Hospital, Nice, 151 Route Saint Antoine de Ginestière, BP 3079, Nice Cedex 3, France.

Purpose: The aim of the study is to compare the outcomes of patients treated with secondary Roux-en-Y gastric bypass (RYGB) after adjustable gastric banding (AGB) or vertical banded gastroplasty (VBG) with those of patients having primary RYGB.

Materials And Methods: Patients undergoing secondary RYGB after AGB or VBG between 1997 and 2004 with a minimal follow-up of 15 years were matched using a propensity score (according to gender, age, BMI, duration of follow-up) with comparable patients who underwent primary RYGB.

Results: The mean follow-up was 16. Read More

Obes Surg 2020 Jun 2. Epub 2020 Jun 2.

Bariatric Unit, Department of General Surgery, PRUH, King's College Hospitals, London, UK.

Obes Surg 2020 Jun 2. Epub 2020 Jun 2.

Physical Therapy Department, Universidad de Chile, Independencia 1027, 8380453, Santiago, Chile.

Purpose: Obesity has been associated with reduced vagal function and increased sympathetic activity. Cardiac autonomic dysfunction has emerged as a major risk factor in the development of cardiovascular disease. Cardiac autonomic function (CAF) can be assessed by heart rate variability (HRV), an independent predictor of mortality based on changes in time intervals between adjacent heartbeats (RR). Read More

Ann Surg Oncol 2020 Jun 2. Epub 2020 Jun 2.

Department of Surgery, University of Florida College of Medicine, Jacksonville, FL, USA.

The increasing prevalence of morbid obesity in the United States has been accompanied by a concomitant rise in bariatric surgery to help combat the epidemic. The relationship between obesity and certain cancers, such as esophageal adenocarcinoma, is well established. The need for minimally invasive techniques to treat esophageal cancer in patients with previous bariatric surgery is growing and can present a unique surgical challenge. Read More

Kidney Res Clin Pract 2020 Jun 3. Epub 2020 Jun 3.

Internal Medicine Department, Mansoura Nephrology and Dialysis Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Background: Bariatric surgeries were reported to improve diabetes and hypertension; however, the effect on renal recovery has not been fully explored. The aim of this study was to evaluate the effect of laparoscopic sleeve gastrectomy (LSG) in morbidly obese patients on renal function, degree of albuminuria, and kidney injury molecule-1 (KIM-1) level.

Methods: This was a prospective observational study conducted at Mansoura University Hospitals from January to June 2017. Read More

Psychosomatics 2020 Apr 29. Epub 2020 Apr 29.

Department of Psychiatry, Antwerp University Hospital, Antwerp, Belgium; Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp, Belgium.

Trials 2020 Jun 2;21(1):448. Epub 2020 Jun 2.

Department of Digestive and Oncological Surgery, Lille University Hospital, Lille, France.

Background: Postoperative upper gastrointestinal fistula (PUGIF) is a devastating complication, leading to high mortality (reaching up to 80%), increased length of hospital stay, reduced health-related quality of life and increased health costs. Nutritional support is a key component of therapy in such cases, which is related to the high prevalence of malnutrition. In the prophylactic setting, enteral nutrition (EN) is associated with a shorter hospital stay, a lower incidence of severe infectious complications, lower severity of complications and decreased cost compared to total parenteral nutrition (TPN) following major upper gastrointestinal (GI) surgery. Read More

Bioengineering (Basel) 2020 May 30;7(2). Epub 2020 May 30.

Department of Industrial Engineering, Centre for Mechanics of Biological Materials, University of Padova, I-35131 Padova, Italy.

Biomechanical investigations of surgical procedures and devices are usually developed by means of human or animal models. The exploitation of computational methods and tools can reduce, refine, and replace (3R) the animal experimentations for scientific purposes and for pre-clinical research. The computational model of a biological structure characterizes both its geometrical conformation and the mechanical behavior of its building tissues. Read More

Obes Surg 2020 Jun 2. Epub 2020 Jun 2.

Department of Radiology, Beijing Friendship Hospital, Capital Medical University, No. 95, Yong An Road, Xicheng District, Beijing, 100050, China.

Purpose: The abdominal magnetic resonance (MR) examinations have been increasingly applied in patients with obesity. However, few studies analyzed the appropriateness of this examination. This study is aimed to evaluate the feasibility and clinical value of upper abdominal MR in quantification of visceral/subcutaneous adipose tissue (VAT/SAT) and liver fat fraction (LFF) in patients before and after bariatric surgery. Read More

Obes Surg 2020 Jun 1. Epub 2020 Jun 1.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Background: This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin.

Methods: PubMed, Scopus, and Google scholar were systematically searched to identify related studies published from inception to November 2019 to find eligible studies.

Results: A total of 29 different studies were included. Read More

Surg Endosc 2020 Jun 1. Epub 2020 Jun 1.

Department of Surgery, University of Michigan, 1500 E Medical Center Drive, SPC 5343, 2210 Taubman Center, Ann Arbor, MI, 48109, USA.

Background: Hiatal hernia repair performed at the time of laparoscopic sleeve gastrectomy (LSG) may reduce post-operative reflux symptoms. It is unclear whether intra-operative diagnosis of hiatal hernia varies among surgeons or if it affects outcomes.

Study Design: Surgeons (n = 38) participating in a statewide bariatric surgery quality improvement collaborative reviewed 33 videos of LSG in which no hiatal hernia repair was performed. Read More

Int Anesthesiol Clin 2020 May 29. Epub 2020 May 29.

Yale School of Medicine, New Haven, Connecticut.

J Musculoskelet Neuronal Interact 2020 Jun;20(2):291-296

Unit of Endocrinology and Diabetes Center, General Hospital of Athens 'G. Gennimatas', Athens, Greece.

Vitamin D (vitD) deficiency and bone loss may occur after bariatric surgery and hence, supplementation with high oral doses of vitD may be required. Alternatively, intramuscular depot ergocalciferol, which slowly releases vitD and bypasses the gastrointestinal tract, could be administrated. We present a case of severe vitD deficiency-osteomalacia after gastric bypass operation for morbid obesity, treated with ergocalciferol intramuscularly. Read More

Anaesthesia 2020 Jun 1. Epub 2020 Jun 1.

Epidemiology and Biostatistics, University of Auckland, Auckland, New Zealand.

Aust N Z J Obstet Gynaecol 2020 Jun 1. Epub 2020 Jun 1.

Australian National University Medical School, Canberra, Australian Capital Territory, Australia.

Obesity and polycystic ovary syndrome (PCOS) are common and have important reproductive consequences: 'metabolic surgery' - bariatric surgery and laparoscopic ovarian drilling (LOD) - have roles in their management. Using national data to determine age-stratified incidence rates of these procedures, we found that bariatric surgery is much more common than LOD. While the uptake of bariatric surgery is rapidly increasing, there has been a decline in the use of LOD in young women. Read More

Ann Med Surg (Lond) 2020 Jul 18;55:143-147. Epub 2020 May 18.

Sunderland Bariatric Unit, Sunderland Royal Hospital, Sunderland, United Kingdom.

Introduction: Most Bariatric units perform Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) and One Anastomosis Gastric Bypass (OAGB) for weight loss and metabolic purposes with satisfactory results and low complication profile.

Objectives: This study compares LRYGB and OAGB outcomes in a high volume single bariatric unit.

Methods: Data was collected prospectively and analysed retrospectively for all LRYGB and OAGB performed between Jan 2014 to Dec 2016. Read More

Front Endocrinol (Lausanne) 2020 13;11:290. Epub 2020 May 13.

Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Lifestyle modifications focused on diet, physical activity, and behavior have a modest impact on weight reduction in children, adolescents, and young adults (YA) with overweight and obesity. Several anti-obesity medications (AOMs) have been approved by the Food and Drug Administration (FDA) for use among adult patients with a body mass index (BMI) ≥27 kg/m and at least one obesity-related illness. However, only two FDA-approved AOMs are available for use in children and adolescents, which leads to the frequent off-label use of adult AOMs among this population. Read More

Front Psychiatry 2020 12;11:419. Epub 2020 May 12.

Department of Psychological Medicine, University of Otago, Wellington, New Zealand.

Background: Bariatric surgery is seldom accessed by people with serious mental illness, despite high rates of obesity in this population. It is sometimes assumed that patients with complex psychiatric histories will have poor post-surgical weight loss or exacerbation of psychiatric symptoms, although this is unsubstantiated.

Objectives: A qualitative descriptive study to explore personal experiences and the impact of bariatric surgery on physical and mental well-being and life-quality in individuals with serious mental illness. Read More

Surg Obes Relat Dis 2020 May 6. Epub 2020 May 6.

Director of Metabolic and Weight Loss Surgery, Department of Surgery, West Virginia University, Morgantown, West Virginia.

Surg Obes Relat Dis 2020 Apr 19. Epub 2020 Apr 19.

Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania.

Background: Long-term changes in cardiovascular disease (CVD) risk after bariatric surgery are not well characterized.

Objective: To report sex-specific changes in CVD risk after Roux-en-Y gastric bypass surgery (RYGB).

Setting: Observational cohort study at ten hospitals throughout the United States. Read More

J Robot Surg 2020 May 30. Epub 2020 May 30.

St. Luke's University Health Network (SLUHN), Bethlehem, PA, USA.

In recent years, there has been a significant increase in the number of Revisional Bariatric Surgery (RBS) cases performed to address complications and weight recidivism. The use of the da Vinci robotic platform, considered controversial by many, may offer advantages in RBS. The objective of our study is to compare the outcomes of Robotic RBS (R-RBS) to Laparoscopic RBS (L-RBS). Read More

Chirurg 2020 May 30. Epub 2020 May 30.

Chirurgische Klinik, Universitätsklinikum Mannheim, Medizinische Fakultät Mannheim, Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.

Surg Obes Relat Dis 2020 Apr 21. Epub 2020 Apr 21.

Department of Gastroenterology, Klinikum-Vest GmbH, Paracelsusklinik Marl, Marl, Germany. Electronic address:

Background: Single-anastomosis duodeno-ileal bypass (SADI) and the one-anastomosis gastric bypass (OAGB) are 2 revisional procedures to address the problem of weight recidivism after laparoscopic sleeve gastrectomy (LSG).

Objectives: To evaluate the efficacy and safety of SADI and OAGB as revisional bariatric surgery (RBS) in initially super-obese patients (body mass index [BMI] >50 kg/m).

Setting: Academic hospital, bariatric center of excellence, Germany. Read More

Surg Obes Relat Dis 2020 Apr 23. Epub 2020 Apr 23.

Department of Surgery, Mayo Clinic, Jacksonville, Florida. Electronic address:

Background: Type 2 diabetes (T2D) is frequently present in Metabolic and Bariatric Surgery (MBS) patients and is associated with increased morbidity and mortality. Organ transplantation patients also suffer from severe obesity and are now increasingly undergoing MBS.

Objective: To determine the association of T2D and perioperative outcomes after MBS in previous solid organ transplantation patients SETTING: University Hospital, United States. Read More

Int J Surg Case Rep 2020 May 19;71:192-195. Epub 2020 May 19.

Department of Surgery, P.O Box 59046, King Fahad Medical City, Riyadh 11525, Saudi Arabia. Electronic address:

Background: The laparoscopic adjustable gastric band is the least invasive bariatric surgery, which has the advantage of preserving the anatomy of the gastrointestinal tract. In the last two decades, the laparoscopic adjustable gastric band (LAGB) has largely been replaced by other surgical techniques for weight loss because of its high inseparable complications. Although a popular surgical technique at the time of its introduction in 1993, LAGB nowadays reports for not more than 5. Read More

Eat Weight Disord 2020 May 29. Epub 2020 May 29.

Arkin, Klaprozenweg 111, 1033 NN, Amsterdam, The Netherlands.

Purpose: Bariatric surgery is the most effective long-term treatment for sustained weight loss in obesity. Studies have shown that not all patients lose the expected amount of weight. The aim of this study was to develop a better understanding of which behavioral and psychological factors are associated with suboptimal weight loss. Read More

Ann Biomed Eng 2020 May 29. Epub 2020 May 29.

Centre for Mechanics of Biological Materials, University of Padova, Padua, Italy.

Obesity is one of the main health concerns worldwide. Bariatric Surgery (BS) is the gold standard treatment for severe obesity. Nevertheless, unsatisfactory weight loss and complications can occur. Read More

Obes Surg 2020 May 29. Epub 2020 May 29.

International Federation for the Surgery of Obesity and Metabolic Disorders, Rione Sirignano, 5, 80121, Naples, Italy.

One of the roles of the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) is to provide guidance on the management of patients seeking surgery for adiposity-based chronic diseases. The role of endoscopy around the time of endoscopy is an area of clinical controversy. In 2018, IFSO commissioned a task force to determine the role of endoscopy before and after surgery for the management of adiposity and adiposity-based chronic diseases. Read More

Obes Surg 2020 May 29. Epub 2020 May 29.

Department of Surgery, Carolinas Medical Center, Atrium Health, Charlotte, NC, USA.

Patients with obesity and diabetes have higher risk for severe complications and mortality from COVID19 infection. In addition, unexpected mortalities were reported in a small series of asymptomatic COVID19-positive patients undergoing metabolic and bariatric surgery (MBS). Several organization including IFSO and the American College of Surgeons (ACS) endorsed recommendations to suspend elective nonessential surgery including MBS during the peak period of COVID19. Read More

Surg Obes Relat Dis 2020 Apr 19. Epub 2020 Apr 19.

Department of Surgery, Oregon Health & Science University, Portland, Oregon.

Background: Bariatric surgery reduces cancer risk in populations with obesity. It is unclear if weight loss alone or metabolic changes related to bariatric surgery cause this effect.

Objective: We evaluated the relationship between surgical weight loss and serum biomarker changes with incident cancer in a bariatric surgery cohort. Read More

Diabetes Metab Res Rev 2020 May 29:e3358. Epub 2020 May 29.

Department of Experimental Medicine, Sapienza University of Rome, Italy.

Aims: Experimental data suggest that visceral adipose tissue (VAT) dysfunction contributes to non-alcoholic fatty liver disease (NAFLD) development in obesity, however data on humans are limited. Aims of this study were to investigate the relationship between NAFLD and VAT morphofunctional impairment and to determine whether the extent of VAT remodeling is associated with liver damage and metabolic alterations in obesity.

Methods: We analyzed data from forty obese individuals candidate to bariatric surgery in whom paired intraoperative liver and omental biopsies were performed for diagnosing NAFLD and VAT inflammation by immunohistochemistry and mRNA expression studies. Read More

Physiol Res 2020 May 29. Epub 2020 May 29.

Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.

Obesity is a disease that affects about 13 % of the world population (2016) (Who 2018). This condition generates a process of systemic inflammation that may contribute to the release of cell-free DNA (cfDNA) into the bloodstream. cfDNA has been considered a potential biomarker to monitor several physiological and pathological conditions, such as tumors, exercise intensity and obesity. Read More