1,278 results match your criteria Banach Journal Of Mathematical Analysis[Journal]


Increase in cerebral blood flow indicated by increased cerebral arterial area and pixel intensity on brain magnetic resonance angiogram following correction of cervical lordosis.

Brain Circ 2019 Jan-Mar;5(1):19-26. Epub 2019 Mar 27.

Molecular, Cellular and Developmental Biology Department, University of Colorado Boulder, Boulder, CO, USA.

Context: Loss of cervical lordosis is associated with decreased vertebral artery hemodynamics.

Aim: The aim of this study is to evaluate cerebral blood flow changes on brain magnetic resonance angiogram (MRA) in patients with loss of cervical lordosis before and following correction of cervical lordosis.

Settings And Design: This study is a retrospective consecutive case series of patients in a private practice. Read More

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http://www.braincirculation.org/text.asp?2019/5/1/19/255020
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http://dx.doi.org/10.4103/bc.bc_25_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458772PMC
March 2019
6 Reads

Impact of ursodeoxycholic acid on circulating lipid concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials.

Lipids Health Dis 2019 Apr 6;18(1):88. Epub 2019 Apr 6.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: The aim of this meta-analysis of randomized placebo-controlled trials was to examine whether ursodeoxycholic acid treatment is an effective lipid-lowering agent.

Methods: PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched in order to find randomized controlled trials evaluating the effect of ursodeoxycholic acid on lipid profile. A random-effect model and the generic inverse variance weighting method were used for quantitative data synthesis. Read More

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http://dx.doi.org/10.1186/s12944-019-1041-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451779PMC
April 2019
2 Reads

Perinatal care in a patient with diagnosed Westphal's disease.

Ginekol Pol 2019 ;90(3):177

Department of Obstetrics and Gynecology, Dictrict Public Hospital in Poznan, Poland.

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http://dx.doi.org/10.5603/GP.2019.0031DOI Listing
January 2019

The value of an initial drop in human Chorionic gonadotropin levels in predicting a response to methotrexate in women with low-risk gestational trophoblastic neoplasia.

Ginekol Pol 2019 ;90(3):141-147

Department of Gynecology, Obstetrics and Gynecologic Oncology, Division of Gynecologic Oncology, Poznan University of Medical Sciences, Poznan, Poland.

Objectives: The early identification of patients who are being treated for low-risk gestational trophoblastic neoplasia (LRGTN) with single-agent chemotherapy, who are at high risk of developing chemoresistance, is of crucial importance. The aim of our research was to evaluate the pretreatment beta subunit of human chorionic gonadotropin (βhCG) concentration and its decrease after the administration of the first course of methotrexate (MTX) in predicting later chemo-resistance to single-agent chemotherapy.

Material And Methods: A total of 46 patients diagnosed with LRGTN treated with a 5-day methotrexate (MTX) regimen were retrospectively studied. Read More

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http://dx.doi.org/10.5603/GP.2019.0025DOI Listing
January 2019

Secondary and Supersecondary Structure of Proteins in Light of the Structure of Hydrophobic Cores.

Methods Mol Biol 2019 ;1958:347-378

Department of Bioinformatics and Telemedicine, Jagiellonian University, Medical College, Kraków, Poland.

The traditional classification of protein structures (with regard to their supersecondary and tertiary conformation) is based on an assessment of conformational similarities between various polypeptide chains and particularly on the presence of specific secondary structural motifs. Mutual relations between secondary folds determine the overall shape of the protein and may be used to assign proteins to specific families (such as the immunoglobulin-like family). An alternative means of conducting structural assessment focuses on the structure of the protein's hydrophobic core. Read More

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http://dx.doi.org/10.1007/978-1-4939-9161-7_19DOI Listing
January 2019

Resource Quantification for the No-Programing Theorem.

Phys Rev Lett 2019 Mar;122(8):080505

Departamento de Análisis Matemático y Matemática Aplicada, Universidad Complutense de Madrid, 28040 Madrid, Spain.

The no-programing theorem prohibits the existence of a universal programmable quantum processor. This statement has several implications in relation to quantum computation but also to other tasks of quantum information processing, making this construction a central notion in this context. Nonetheless, it is well known that, even when the strict model is not implementable, it is possible to conceive of it in an approximate sense. Read More

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http://dx.doi.org/10.1103/PhysRevLett.122.080505DOI Listing

Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia and Statin Intolerance.

J Am Heart Assoc 2019 Apr;8(7):e011662

6 Department of Vascular Medicine Academic Medical Center of Amsterdam Netherlands.

Background Inability to tolerate statins because of muscle symptoms contributes to uncontrolled cholesterol levels and insufficient cardiovascular risk reduction. Bempedoic acid, a prodrug that is activated by a hepatic enzyme not present in skeletal muscle, inhibits ATP -citrate lyase, an enzyme upstream of β-hydroxy β-methylglutaryl-coenzyme A reductase in the cholesterol biosynthesis pathway. Methods and Results The phase 3, double-blind, placebo-controlled CLEAR (Cholesterol Lowering via Bempedoic acid, an ACL-Inhibiting Regimen) Serenity study randomized 345 patients with hypercholesterolemia and a history of intolerance to at least 2 statins (1 at the lowest available dose) 2:1 to bempedoic acid 180 mg or placebo once daily for 24 weeks. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.011662
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http://dx.doi.org/10.1161/JAHA.118.011662DOI Listing
April 2019
4 Reads

Fine-needle aspiration of dermatofibrosarcoma protuberans metastasizing to hemithorax with superior vena cava compression: Case report and literature review.

Diagn Cytopathol 2019 Mar 27. Epub 2019 Mar 27.

Department of Pathology, The University of Chicago, Chicago, Illinois.

Dermatofibrosarcoma protuberans (DFSP) is a low-grade spindle cell tumor of the skin commonly arising on the trunk and extremities which tends to be slow growing yet locally aggressive. DFSPs are associated with a good prognosis when surgical excision with negative margins is achieved. Although local recurrences occur up to 50% of incompletely resected cases, distant metastases are very rare. Read More

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http://dx.doi.org/10.1002/dc.24179DOI Listing

SIAXI: Placebo-controlled, randomized, double-blind study of incobotulinumtoxinA for sialorrhea.

Neurology 2019 Mar 27. Epub 2019 Mar 27.

From the Parkinson-Klinik Ortenau (W.H.J.), Wolfach, Germany; Department of Neurology (A.F.), Faculty of Health Science, Medical University of Warsaw, Poland; Department of Otorhinolaryngology (O.M.), University Hospital Brussels, Vrije Universiteit Brussel, Belgium; Neurological Outpatient Clinic for Parkinson's Disease and Deep Brain Stimulation (C.O.), Gera, Germany; Department of Neurological-Psychiatric Nursing (J.S.), Medical University of Gdansk; Neurology Department (J.S.), St. Adalbert Hospital, Gdansk; Department of Extrapyramidal Diseases (A. Bogucki), Medical University of Łódź; Department of Neurology and Stroke Unit (S.O.), Medical University of Silesia, Katowice; Department of Neurology (M.B.), Collegium Medicum, Jagiellonian University, Krakow, Poland; Department of Neurology (F.P.), Georgetown University Hospital, Washington, DC; Merz Pharmaceuticals GmbH (B.F.-B., J.C.), Frankfurt am Main, Germany; Complete Medical Communications (C.J.C.), Glasgow, UK; Department of Otolaryngology/Head and Neck Surgery (A. Blitzer), Columbia University College of Physicians and Surgeons, New York; Department of Neurology (A. Blitzer), Icahn School of Medicine at Mt. Sinai, New York; and NY Center for Voice and Swallowing Disorders (A. Blitzer), New York, NY.

Objective: This pivotal phase III study, SIAXI, investigated the efficacy and safety of incobotulinumtoxinA for the treatment of chronic sialorrhea due to Parkinson disease (PD), atypical parkinsonism, stroke, or traumatic brain injury (TBI).

Methods: Adult patients with PD (70.7%), atypical parkinsonism (8. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007368DOI Listing
March 2019
1 Read

A review of gene- and cell-based therapies for familial hypercholesterolemia.

Pharmacol Res 2019 May 22;143:119-132. Epub 2019 Mar 22.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Familial hypercholesterolemia (FH) is a genetic autosomal dominant disorder caused by an impaired receptor-mediated low-density lipoprotein (LDL) removal from the circulation, mainly due to disruptive autosomal co-dominant mutations in the LDL receptor (LDLr) gene, but also less frequently in the apolipoprotein B100 (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes. A rare form of autosomal recessive FH has been also described due to LDLr adaptor protein 1 (LDLRAP1) gene mutations. FH is characterized by very high levels of plasma LDL cholesterol associated with the high incidence of premature atherosclerotic cardiovascular disease (CVD). Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.016DOI Listing
May 2019
1 Read

Beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis.

Arch Med Sci 2019 Mar 4;15(2):385-392. Epub 2019 Mar 4.

Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland.

Introduction: Statins are widely used in stroke patients. The AHA/ASA guidelines recommend aggressive statin therapy in atherosclerotic stroke patients. Their beneficial effects are due to both their hypolipemic and pleiotropic properties. Read More

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http://dx.doi.org/10.5114/aoms.2019.82925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425215PMC
March 2019
1 Read

Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Authors:

Lancet Neurol 2019 May 14;18(5):459-480. Epub 2019 Mar 14.

Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.

Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. Read More

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http://dx.doi.org/10.1016/S1474-4422(18)30499-XDOI Listing
May 2019
2 Reads
21.896 Impact Factor

Ideal cardiovascular health associated with fatty liver: Results from a multi-ethnic survey.

Atherosclerosis 2018 Nov 8;284:129-135. Epub 2018 Nov 8.

Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland.

Background And Aims: Little is known about the role of liver enzymes as predictors of non-liver-related morbidity and mortality. The ideal cardiovascular health (CVH) score proposed by the American Heart Association (AHA) can be used to predict mortality and morbidity. We investigated the association of the CVH score with liver enzymes and the risk of non-alcoholic fatty liver disease (NAFLD) among US adults. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.11.012DOI Listing
November 2018

Association of ideal cardiovascular health metrics with serum uric acid, inflammation and atherogenic index of plasma: A population-based survey.

Atherosclerosis 2018 Sep 15;284:44-49. Epub 2018 Sep 15.

Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland.

Background And Aims: We aimed to evaluate the link between inflammatory score [consisting of C-reactive protein (CRP) and white blood cells], serum uric acid (SUA) and atherogenic index of plasma (AIP) and the cardiovascular health (CVH) score.

Methods: We used the cross-sectional National Health and Nutrition Examination Survey database. Statistical analyses accounted for the survey design and sample weights. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219150183137
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http://dx.doi.org/10.1016/j.atherosclerosis.2018.09.016DOI Listing
September 2018
5 Reads

Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Authors:

Lancet Neurol 2019 May 11;18(5):439-458. Epub 2019 Mar 11.

Background: Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information to health systems and policy makers on more than 300 causes of disease and injury, including stroke. The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016. Read More

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http://dx.doi.org/10.1016/S1474-4422(19)30034-1DOI Listing
May 2019
2 Reads
21.896 Impact Factor

Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol.

N Engl J Med 2019 03;380(11):1022-1032

From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY (H.E.B.); the University of Milan and Multimedica IRCCS, Milan (A.L.C.); Esperion Therapeutics, Ann Arbor, MI (N.D.L., L.T.B., L.R.S., P.L.R.); and Baylor College of Medicine, Houston (C.M.B.).

Background: Short-term studies have shown that bempedoic acid, an inhibitor of ATP citrate lyase, reduces levels of low-density lipoprotein (LDL) cholesterol. Data are limited regarding the safety and efficacy of bempedoic acid treatment in long-term studies involving patients with hypercholesterolemia who are receiving guideline-recommended statin therapy.

Methods: We conducted a randomized, controlled trial involving patients with atherosclerotic cardiovascular disease, heterozygous familial hypercholesterolemia, or both. Read More

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http://dx.doi.org/10.1056/NEJMoa1803917DOI Listing
March 2019
2 Reads

Safety of red yeast rice supplementation: A systematic review and meta-analysis of randomized controlled trials.

Pharmacol Res 2019 May 4;143:1-16. Epub 2019 Mar 4.

Department of Medicine and Surgery Sciences, University of Bologna, Bologna, Italy. Electronic address:

Recently, concerns regarding the safety of red yeast rice (RYR) have been raised after the publication of some case reports claiming toxicity. Since the previous meta-analyses on the effects of RYR were mainly focused on its efficacy to improve lipid profile and other cardiovascular parameters, we carried out a meta-analysis on safety data derived from the available randomized controlled clinical trials (RCTs). Primary outcomes were musculoskeletal disorders (MuD). Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.028DOI Listing
May 2019
11 Reads

Novel therapeutic strategies for stroke: The role of autophagy.

Crit Rev Clin Lab Sci 2019 Mar 1:1-18. Epub 2019 Mar 1.

u Department of Pharmacology, School of Pharmacy , Kermanshah University of Medical Sciences , Kermanshah , Iran.

Autophagy is an important biological mechanism involved in the regulation of numerous fundamental cellular processes that are mainly associated with cellular growth and differentiation. Autophagic pathways are vital for maintaining cellular homeostasis by enhancing the turnover of nonfunctional proteins and organelles. Neuronal cells, like other eukaryotic cells, are dependent on autophagy for neuroprotection in response to stress, but can also induce cell death in cerebral ischemia. Read More

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https://www.tandfonline.com/doi/full/10.1080/10408363.2019.1
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http://dx.doi.org/10.1080/10408363.2019.1575333DOI Listing
March 2019
4 Reads

ETC-1002 (Bempedoic acid) for the management of hyperlipidemia: from preclinical studies to phase 3 trials.

Expert Opin Pharmacother 2019 May 27;20(7):791-803. Epub 2019 Feb 27.

h Dyslipidemia Center , A.S.S.T. Grande Ospedale Metropolitano Niguarda , Milan , Italy.

Introduction: Tolerability problems in treating hypercholesterolemic patients undergoing statin treatment are of growing concern to physicians and patients, thus underlining the need for an agent with a similar mechanism but minimal side effects. A drug with a somewhat similar mechanism to statins but free of muscular side effects is ETC-1002 (bempedoic acid). It inhibits cholesterol biosynthesis at a step preceding HMG-CoA reductase, i. Read More

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http://dx.doi.org/10.1080/14656566.2019.1583209DOI Listing
May 2019
1 Read

Effect of fenofibrate on plasma apolipoprotein C-III levels: a systematic review and meta-analysis of randomised placebo-controlled trials.

BMJ Open 2019 Feb 22;8(11):e021508. Epub 2019 Feb 22.

Weill Cornell Medicine Qatar, Doha, Qatar.

Objectives: This meta-analysis of randomised placebo-controlled clinical trials aimed to assess the effect of fenofibrate on apolipoprotein C-III (apo C-III), a key regulator of triglyceride metabolism.

Materials And Methods: Randomised placebo-controlled trials investigating the impact of fenofibrate treatment on apo C-III levels were searched in PubMed-Medline, Scopus, Web of Science and Google Scholar databases from inception to 18 August 2017. Quantitative data synthesis was determined by a random-effects model and generic inverse variance method. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-021508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278807PMC
February 2019

Changes in circulating pro-protein convertase subtilisin/kexin type 9 levels - experimental and clinical approaches with lipid-lowering agents.

Eur J Prev Cardiol 2019 Feb 18:2047487319831500. Epub 2019 Feb 18.

1 Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Italy.

Regulation of pro-protein convertase subtilisin/kexin type 9 (PCSK9) by drugs has led to the development of a still small number of agents with powerful activity on low-density lipoprotein cholesterol levels, associated with a significant reduction of cardiovascular events in patients in secondary prevention. The Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk (FOURIER) and Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab (ODYSSEY OUTCOMES) studies, with the two available PCSK9 antagonists, i.e. Read More

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http://dx.doi.org/10.1177/2047487319831500DOI Listing
February 2019
1 Read

MALDI-TOF-MS Analysis in the Identification of Urine Proteomic Patterns of Gestational Trophoblastic Disease.

Metabolites 2019 Feb 9;9(2). Epub 2019 Feb 9.

Gynecologic Oncology Department, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.

Gestational trophoblastic disease (GTD) is a group of highly aggressive, rare tumors. Human chorionic gonadotropin is a common biomarker used in the diagnosis and monitoring of GTD. To improve our knowledge of the pathology of GTD, we performed protein-peptide profiling on the urine of patients affected with gestational trophoblastic neoplasm (GTN). Read More

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http://dx.doi.org/10.3390/metabo9020030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409522PMC
February 2019
2 Reads

Antitumor effects of curcumin: A lipid perspective.

J Cell Physiol 2019 Feb 11. Epub 2019 Feb 11.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Lipid metabolism plays an important role in cancer development due to the necessities of rapidly dividing cells to increase structural, energetic, and biosynthetic demands for cell proliferation. Basically, obesity, type 2 diabetes, and other related diseases, and cancer are associated with a common hyperactivated "lipogenic state." Recent evidence suggests that metabolic reprogramming and overproduction of enzymes involved in the synthesis of fatty acids are the new hallmarks of cancer, which occur in an early phase of tumorigenesis. Read More

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http://doi.wiley.com/10.1002/jcp.28262
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http://dx.doi.org/10.1002/jcp.28262DOI Listing
February 2019
7 Reads

A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations.

Arch Med Sci 2019 Jan 30;15(1):12-22. Epub 2018 Dec 30.

Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland.

Introduction: Many experimental and clinical trials have suggested that flaxseed might be a potent antihypertensive, but the evidence concerning the effects of flaxseed supplements on plasma C-reactive protein (CRP) concentrations has not been fully conclusive. We assessed the impact of the effects of flaxseed supplementation on plasma CRP concentrations through a systematic review of literature and meta-analysis of available randomised controlled trials (RCTs).

Material And Methods: The literature search included EMBASE, ProQuest, CINAHL, and PUBMED databases up to 1 February 2016 to identify RCTs investigating the effect of flaxseed supplements on plasma CRP concentrations. Read More

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http://dx.doi.org/10.5114/aoms.2018.81034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348364PMC
January 2019

Effect of Statin Therapy on Arterial Wall Inflammation Based on 18F-FDG PET/CT: A Systematic Review and Meta-Analysis of Interventional Studies.

J Clin Med 2019 Jan 18;8(1). Epub 2019 Jan 18.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.

To evaluate by meta-analysis of interventional studies the effect of statin therapy on arterial wall inflammation. Arterial exposure to low-density lipoprotein (LDL) cholesterol levels is responsible for initiation and progression of atherosclerosis and arterial wall inflammation. 18F-fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (18F-FDG PET/CT) has been used to detect arterial wall inflammation and monitor the vascular anti-inflammatory effects of lipid-lowering therapy. Read More

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http://dx.doi.org/10.3390/jcm8010118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352284PMC
January 2019
1 Read

Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent.

J Nutr Biochem 2019 Apr 21;66:1-16. Epub 2018 Dec 21.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Medicine, University of Western Australia, Perth, Australia. Electronic address:

Monocytes and macrophages are important cells of the innate immune system that have diverse functions, including defense against invading pathogens, removal of dead cells by phagocytosis, antigen presentation in the context of MHC class I and class II molecules, and production of various pro-inflammatory cytokines and chemokines such as IL-1β, IL-6, TNF-α and MCP-1. In addition, pro-inflammatory (M1) and anti-inflammatory (M2) macrophages clearly play important roles in the progression of several inflammatory diseases. Therefore, therapies that target macrophage polarization and function by either blocking their trafficking to sites of inflammation, or skewing M1 to M2 phenotype polarization may hold clinical promise in several inflammatory diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09552863183070
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http://dx.doi.org/10.1016/j.jnutbio.2018.12.005DOI Listing
April 2019
14 Reads

Dietary natural products as emerging lipoprotein(a)-lowering agents.

J Cell Physiol 2019 Jan 13. Epub 2019 Jan 13.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Elevated plasma lipoprotein(a) (Lp(a)) levels are associated with an increased risk of cardiovascular disease (CVD). Hitherto, niacin has been the drug of choice to reduce elevated Lp(a) levels in hyperlipidemic patients but its efficacy in reducing CVD outcomes has been seriously questioned by recent clinical trials. Additional drugs may reduce to some extent plasma Lp(a) levels but the lack of a specific therapeutic indication for Lp(a)-lowering limits profoundly reduce their use. Read More

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http://dx.doi.org/10.1002/jcp.28134DOI Listing
January 2019
4 Reads
3.839 Impact Factor

A higher flavonoid intake is associated with less likelihood of nonalcoholic fatty liver disease: results from a multiethnic study.

J Nutr Biochem 2019 Mar 11;65:66-71. Epub 2018 Oct 11.

Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland.

Limited information exists on the impact of flavonoid intake on nonalcoholic fatty liver disease (NAFLD). We evaluated the link between flavonoid intake, liver tests and risk of NAFLD in a randomly selected sample of US adults (from the National Health and Nutrition Examination Survey, NHANES, 2005-2010). Of the 17,685 participants, 46. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2018.10.001DOI Listing
March 2019
2 Reads

Oxidative Stress in Women Treated with Atosiban for Impending Preterm Birth.

Oxid Med Cell Longev 2018 2;2018:3919106. Epub 2018 Dec 2.

Department of Hypertension, Medical University of Lodz, Lodz 90-549, Poland.

Preterm birth is defined as delivery before 37 completed weeks of pregnancy, and it is the leading cause of neonatal morbidity and mortality. Oxidative stress is recognized as an important factor in the pathogenesis of premature labor. We conducted this analysis to investigate the safety of administration of the tocolytic drug Atosiban-a reversible, competitive antagonist of the oxytocin receptor in the treatment of preterm birth and its impact on the level of oxidative stress in pregnant women after 48 hours of tocolytic treatment. Read More

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http://dx.doi.org/10.1155/2018/3919106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304866PMC
March 2019
3 Reads

Correction to: Nuts as a replacement for carbohydrates in the diabetic diet: a reanalysis of a randomised controlled trial.

Diabetologia 2019 03;62(3):549-552

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 5th Floor, Medical Science Building (MSB), 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada.

In contrast to statements made in the above paper, measurements of waist and hip circumference were in fact available. Read More

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http://link.springer.com/10.1007/s00125-018-4795-8
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http://dx.doi.org/10.1007/s00125-018-4795-8DOI Listing
March 2019
8 Reads
6.671 Impact Factor

The Polish version of the Boston Carpal Tunnel Questionnaire: Associations between patient-rated outcome measures and nerve conduction studies.

J Plast Reconstr Aesthet Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, Jagiellonian University Medical College, Kraków, Poland.

Purpose: The aim of this study was to investigate the associations between nerve conduction studies and three commonly used patient-reported outcome measures (Disabilities of the Arm, Shoulder and Hand [DASH], Michigan Hand Outcomes Questionnaire [MHQ], and the Polish version of the Boston Carpal Tunnel Questionnaire [BCTQ]) METHODS: A total of 218 consecutive patients with carpal tunnel syndrome (CTS) completed the BCTQ, MHQ, and DASH questionnaires followed by nerve conduction studies on their first visit to the clinic.

Results: After a 14-day interval, 189 of these patients completed the BCTQ for the second time. The Polish version of the BCTQ was shown to have excellent internal consistency, test-retest reliability, and validity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17486815183047
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http://dx.doi.org/10.1016/j.bjps.2018.12.032DOI Listing
December 2018
6 Reads

What have we learned about lipids and cardiovascular risk from PCSK9 inhibitor outcome trials: ODYSSEY and FOURIER?

Cardiovasc Res 2019 Mar;115(3):e26-e31

School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.

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http://dx.doi.org/10.1093/cvr/cvy301DOI Listing
March 2019
2 Reads
5.940 Impact Factor

Consumption of dairy product and its association with total and cause specific mortality - A population-based cohort study and meta-analysis.

Clin Nutr 2018 Dec 18. Epub 2018 Dec 18.

Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland. Electronic address:

Background: The intake of dairy products has been thought to be associated with an increased risk of coronary heart diseases (CHD) and total mortality due to its relatively high content of saturated fat. However, reports on this association particularly among US adults are conflicting and controversial. Therefore, we used data from the 1999-2010 National Health and Nutrition Examination Surveys (NHANES) study to examine whether consumption of total dairy and dairy subgroups was associated with total and cause specific (CHD, cerebrovascular and cancer) mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614183258
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http://dx.doi.org/10.1016/j.clnu.2018.12.015DOI Listing
December 2018
14 Reads

Expression of collagens type I and V in healing rat's tympanic membrane.

Int J Pediatr Otorhinolaryngol 2019 Mar 18;118:79-83. Epub 2018 Dec 18.

Department of Pediatric Otolaryngology, Medical University of Białystok, Waszyngtona 17, 15-274, Białystok, Poland. Electronic address:

Objectives: Our preliminary study performed on perforated rat's tympanic membrane (TM) using Rat Wound Healing RT2 Profiler PCR Array showed significantly increased levels of mRNA for collagens type I and V. Enhanced expression of those genes does not assure that their protein products are indeed present, and in what quantity. Therefore, this study was undertaken to analyze the collagen type I and V content in the healing TM. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.12.020DOI Listing
March 2019
3 Reads

The aqueous environment as an active participant in the protein folding process.

J Mol Graph Model 2019 Mar 14;87:227-239. Epub 2018 Dec 14.

Department of Bioinformatics and Telemedicine, Jagiellonian University - Medical College, Łazarza 16, 31-530, Kraków, Poland. Electronic address:

Existing computational models applied in the protein structure prediction process do not sufficiently account for the presence of the aqueous solvent. The solvent is usually represented by a predetermined number of HO molecules in the bounding box which contains the target chain. The fuzzy oil drop (FOD) model, presented in this paper, follows an alternative approach, with the solvent assuming the form of a continuous external hydrophobic force field, with a Gaussian distribution. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10933263183060
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http://dx.doi.org/10.1016/j.jmgm.2018.12.008DOI Listing
March 2019
8 Reads

Bacterial cellulose as a support for yeast immobilization - Correlation between carrier properties and process efficiency.

J Biotechnol 2019 Feb 20;291:1-6. Epub 2018 Dec 20.

West Pomeranian University of Technology in Szczecin, Faculty of Biotechnology and Animal Husbandry, Department of Immunology, Microbiology and Physiological Chemistry, Piastów 45, 70-311 Szczecin, Poland. Electronic address:

The aim of the current study was to analyze physicochemical properties of bacterial cellulose (BC) produced by Komagataeibacter xylinus for various periods of time in stationary conditions with regard to its potential as a carrier for yeast (Saccharomyces cerevisiae and Yarrowia lipolytica) immobilization, and subsequently to correlate the relationship between these properties and the efficiency of the immobilization process. Physicochemical properties of BC, depending on the time of its biosynthesis, were as follows: surface area 7.21-11. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2018.12.010DOI Listing
February 2019
4 Reads

Associations between cardiovascular disease, cancer, and very low high-density lipoprotein cholesterol in the REasons for Geographical and Racial Differences in Stroke (REGARDS) study.

Cardiovasc Res 2019 Jan;115(1):204-212

Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Zeromskiego 113, 90-549 Lodz, Poland.

Aims: Relatively little is known about the health outcomes associated with very low plasma concentrations of high-density lipoprotein cholesterol (HDL-C) mainly because of the small numbers of individuals with such extreme values included in clinical trials. We, therefore, investigated the association between low and very low HDL-C concentration at baseline and incident all-cause-mortality, death from malignant disease (i.e. Read More

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https://academic.oup.com/cardiovascres/article/115/1/204/506
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http://dx.doi.org/10.1093/cvr/cvy198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302258PMC
January 2019
13 Reads
5.940 Impact Factor

Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016.

Authors:
Valery L Feigin Grant Nguyen Kelly Cercy Catherine O Johnson Tahiya Alam Priyakumari G Parmar Amanuel A Abajobir Kalkidan H Abate Foad Abd-Allah Ayenew N Abejie Gebre Y Abyu Zanfina Ademi Gina Agarwal Muktar B Ahmed Rufus O Akinyemi Rajaa Al-Raddadi Leopold N Aminde Catherine Amlie-Lefond Hossein Ansari Hamid Asayesh Solomon W Asgedom Tesfay M Atey Henok T Ayele Maciej Banach Amitava Banerjee Aleksandra Barac Suzanne L Barker-Collo Till Bärnighausen Lars Barregard Sanjay Basu Neeraj Bedi Masoud Behzadifar Yannick Béjot Derrick A Bennett Isabela M Bensenor Derbew F Berhe Dube J Boneya Michael Brainin Ismael R Campos-Nonato Valeria Caso Carlos A Castañeda-Orjuela Jacquelin C Rivas Ferrán Catalá-López Hanne Christensen Michael H Criqui Albertino Damasceno Lalit Dandona Rakhi Dandona Kairat Davletov Barbora de Courten Gabrielle deVeber Klara Dokova Dumessa Edessa Matthias Endres Emerito J A Faraon Maryam S Farvid Florian Fischer Kyle Foreman Mohammad H Forouzanfar Seana L Gall Tsegaye T Gebrehiwot Johanna M Geleijnse Richard F Gillum Maurice Giroud Alessandra C Goulart Rahul Gupta Rajeev Gupta Vladimir Hachinski Randah R Hamadeh Graeme J Hankey Habtamu A Hareri Rasmus Havmoeller Simon I Hay Mohamed I Hegazy Desalegn T Hibstu Spencer L James Panniyammakal Jeemon Denny John Jost B Jonas Jacek Jóźwiak Rizwan Kalani Amit Kandel Amir Kasaeian Andre P Kengne Yousef S Khader Abdur R Khan Young-Ho Khang Jagdish Khubchandani Daniel Kim Yun J Kim Mika Kivimaki Yoshihiro Kokubo Dhaval Kolte Jacek A Kopec Soewarta Kosen Michael Kravchenko Rita Krishnamurthi G Anil Kumar Alessandra Lafranconi Pablo M Lavados Yirga Legesse Yongmei Li Xiaofeng Liang Warren D Lo Stefan Lorkowski Paulo A Lotufo Clement T Loy Mark T Mackay Hassan Magdy Abd El Razek Mahdi Mahdavi Azeem Majeed Reza Malekzadeh Deborah C Malta Abdullah A Mamun Lorenzo G Mantovani Sheila C O Martins Kedar K Mate Mohsen Mazidi Suresh Mehata Toni Meier Yohannes A Melaku Walter Mendoza George A Mensah Atte Meretoja Haftay B Mezgebe Tomasz Miazgowski Ted R Miller Norlinah M Ibrahim Shafiu Mohammed Ali H Mokdad Mahmood Moosazadeh Andrew E Moran Kamarul I Musa Ruxandra I Negoi Minh Nguyen Quyen L Nguyen Trang H Nguyen Tung T Tran Thanh T Nguyen Dina Nur Anggraini Ningrum Bo Norrving Jean J Noubiap Martin J O’Donnell Andrew T Olagunju Oyere K Onuma Mayowa O Owolabi Mahboubeh Parsaeian George C Patton Michael Piradov Martin A Pletcher Farshad Pourmalek V Prakash Mostafa Qorbani Mahfuzar Rahman Muhammad A Rahman Rajesh K Rai Annemarei Ranta David Rawaf Salman Rawaf Andre MN Renzaho Stephen R Robinson Ramesh Sahathevan Amirhossein Sahebkar Joshua A Salomon Paola Santalucia Itamar S Santos Benn Sartorius Aletta E Schutte Sadaf G Sepanlou Azadeh Shafieesabet Masood A Shaikh Morteza Shamsizadeh Kevin N Sheth Mekonnen Sisay Min-Jeong Shin Ivy Shiue Diego A S Silva Eugene Sobngwi Michael Soljak Reed J D Sorensen Luciano A Sposato Saverio Stranges Rizwan A Suliankatchi Rafael Tabarés-Seisdedos David Tanne Cuong Tat Nguyen J S Thakur Amanda G Thrift David L Tirschwell Roman Topor-Madry Bach X Tran Luong T Nguyen Thomas Truelsen Nikolaos Tsilimparis Stefanos Tyrovolas Kingsley N Ukwaja Olalekan A Uthman Yuri Varakin Tommi Vasankari Narayanaswamy Venketasubramanian Vasiliy V Vlassov Wenzhi Wang Andrea Werdecker Charles D A Wolfe Gelin Xu Yuichiro Yano Naohiro Yonemoto Chuanhua Yu Zoubida Zaidi Maysaa El Sayed Zaki Maigeng Zhou Boback Ziaeian Ben Zipkin Theo Vos Mohsen Naghavi Christopher J L Murray Gregory A Roth

N Engl J Med 2018 12;379(25):2429-2437

Background: The lifetime risk of stroke has been calculated in a limited number of selected populations. We sought to estimate the lifetime risk of stroke at the regional, country, and global level using data from a comprehensive study of the prevalence of major diseases.

Methods: We used the Global Burden of Disease (GBD) Study 2016 estimates of stroke incidence and the competing risks of death from any cause other than stroke to calculate the cumulative lifetime risks of first stroke, ischemic stroke, or hemorrhagic stroke among adults 25 years of age or older. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1804492
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http://dx.doi.org/10.1056/NEJMoa1804492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247346PMC
December 2018
26 Reads
55.873 Impact Factor

Impact of ezetimibe on plasma lipoprotein(a) concentrations as monotherapy or in combination with statins: a systematic review and meta-analysis of randomized controlled trials.

Sci Rep 2018 Dec 14;8(1):17887. Epub 2018 Dec 14.

Weill Cornell Medicine Qatar, Doha, Qatar.

The aim of this meta-analysis of randomized placebo-controlled clinical trials was to assess the effect of ezetimibe on plasma lipoprotein(a) concentrations. Only randomized placebo-controlled trials investigating the impact of ezetimibe treatment on cholesterol lowering that include lipoprotein(a) measurement were searched in PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases (from inception to February 26, 2018). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Read More

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http://dx.doi.org/10.1038/s41598-018-36204-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294784PMC
December 2018
13 Reads

Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity.

J Clin Invest 2019 Jan 10;129(1):349-363. Epub 2018 Dec 10.

Department of Hematology and Oncology, School of Medicine, UCSF, San Francisco, California, USA.

While immune checkpoint blockade leads to potent antitumor efficacy, it also leads to immune-related adverse events in cancer patients. These toxicities stem from systemic immune activation resulting in inflammation of multiple organs, including the gastrointestinal tract, lung, and endocrine organs. We developed a dual variable domain immunoglobulin of anti-CTLA4 antibody (anti-CTLA4 DVD, where CTLA4 is defined as cytotoxic T lymphocyte-associated antigen-4) possessing an outer tumor-specific antigen-binding site engineered to shield the inner anti-CTLA4-binding domain. Read More

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https://www.jci.org/articles/view/123391
Publisher Site
http://dx.doi.org/10.1172/JCI123391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307943PMC
January 2019
6 Reads

Characteristics of lipid profile and effectiveness of management of dyslipidaemia in patients with acute coronary syndromes - Data from the TERCET registry with 19,287 patients.

Pharmacol Res 2019 01 6;139:460-466. Epub 2018 Dec 6.

Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland. Electronic address:

Despite well-defined therapeutic low-density lipoprotein cholesterol (LDL-C) target in the highest-risk population, low percentage of patients is administered with intensive lipid-lowering therapy and achieves recommended levels. Therefore, based on the Hyperlipidaemia Therapy in tERtiary Cardiological cEnTer (TERCET) Registry data we investigated the characteristics of lipid profile and management of dyslipidemia in acute coronary syndrome (ACS) patients. 19,287 consecutive patients hospitalized between 2006 and 2016 have been included in the study. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.12.002DOI Listing
January 2019
4 Reads

Impact of Body Mass Index on Outcomes in the Edoxaban Versus Warfarin Therapy Groups in Patients Underwent Cardioversion of Atrial Fibrillation (from ENSURE-AF).

Am J Cardiol 2019 Feb 24;123(4):592-597. Epub 2018 Nov 24.

St. Vincenz-Hospital, Paderborn, Germany; Working Group: Molecular Electrophysiology, University Hospital Magdeburg, Magdeburg, Germany.

In the EdoxabaN versus warfarin in subjectS UndeRgoing cardiovErsion of Atrial Fibrillation study (NCT 02072434), edoxaban showed similar efficacy and safety versus enoxaparin-warfarin in patients underwent electrical cardioversion of nonvalvular atrial fibrillation. In this ancillary analysis, we compared the primary efficacy (composite of stroke, systemic embolic event, myocardial infarction, cardiovascular death, and overall study period) and safety (composite of major and clinically relevant nonmajor bleeding, on-treatment) end points in relation to body mass index (BMI; <30 vs ≥30 kg/m). We also compared cardioversion outcomes in relation to BMI. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.019DOI Listing
February 2019
5 Reads

Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017.

Authors:

Lancet 2018 11 8;392(10159):2091-2138. Epub 2018 Nov 8.

Background: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of "leaving no one behind", it is increasingly important to examine the health-related SDGs beyond national-level estimates. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), we measured progress on 41 of 52 health-related SDG indicators and estimated the health-related SDG index for 195 countries and territories for the period 1990-2017, projected indicators to 2030, and analysed global attainment. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32281-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6227911PMC
November 2018
10 Reads
53.254 Impact Factor

Population and fertility by age and sex for 195 countries and territories, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Authors:

Lancet 2018 11 8;392(10159):1995-2051. Epub 2018 Nov 8.

Background: Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility, although useful, have not been produced with transparent and replicable methods and do not use standardised estimates of mortality. We present single-calendar year and single-year of age estimates of fertility and population by sex with standardised and replicable methods. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32278-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6227915PMC
November 2018
3 Reads
53.254 Impact Factor

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Authors:

Lancet 2018 11 8;392(10159):1923-1994. Epub 2018 Nov 8.

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk-outcome associations.

Methods: We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32225-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6227755PMC
November 2018
1 Read
53.254 Impact Factor

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Authors:

Lancet 2018 11 8;392(10159):1789-1858. Epub 2018 Nov 8.

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183227
Publisher Site
http://dx.doi.org/10.1016/S0140-6736(18)32279-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6227754PMC
November 2018
8 Reads
53.254 Impact Factor

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Authors:

Lancet 2018 11 8;392(10159):1736-1788. Epub 2018 Nov 8.

Background: Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly available data and improved methods. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32203-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6227606PMC
November 2018
15 Reads
53.254 Impact Factor

Global, regional, and national age-sex-specific mortality and life expectancy, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Authors:

Lancet 2018 11 8;392(10159):1684-1735. Epub 2018 Nov 8.

Background: Assessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UNPOP), the United States Census Bureau, WHO, and as part of previous iterations of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). Previous iterations of the GBD used population estimates from UNPOP, which were not derived in a way that was internally consistent with the estimates of the numbers of deaths in the GBD. The present iteration of the GBD, GBD 2017, improves on previous assessments and provides timely estimates of the mortality experience of populations globally. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)31891-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6227504PMC
November 2018
12 Reads
53.254 Impact Factor