5,779 results match your criteria Bacteroides Infection


Two Strains of Effectively Decrease the Colonization of VRE in a Mouse Model.

Front Cell Infect Microbiol 2019 30;9. Epub 2019 Jan 30.

State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention - Chinese Center for Disease Control and Prevention, Beijing, China.

(VRE) infection is a serious challenge for clinical management and there is no effective treatment at present. Fecal microbiota transplantation (FMT) and probiotic intervention have been shown to be promising approaches for reducing the colonization of certain pathogenic bacteria in the gastrointestinal tract, however, no such studies have been done on VRE. In this study, we evaluated the effect of FMT and two strains (Y74 and HT121) on the colonization of VRE in a VRE-infection mouse model. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00006
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http://dx.doi.org/10.3389/fcimb.2019.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363661PMC
January 2019
1 Read

Dynamics of the Gut Microbiota in Children Receiving Selective or Total Gut Decontamination Treatment During Hematopoietic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2019 Feb 4. Epub 2019 Feb 4.

Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands; Center for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, the Netherlands.

Bloodstream infections and Graft-versus-Host disease (GvHD) are common complications after hematopoietic stem cell transplantation (HSCT) procedures, associated with the gut microbiota which acts as a reservoir for opportunistic pathogens. Selective gut decontamination (SGD) and total gut decontamination (TGD) during HSCT have been associated with a decreased risk of developing these complications after transplantation. However, since studies have shown conflicting results, the use of these treatments remain subject of debate. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.01.037DOI Listing
February 2019
1 Read

Puerariae Lobatae Radix with Chuanxiong Rhizoma for treatment of cerebral ischemic stroke by remodeling gut microbiota to regulate the brain-gut barriers of dietary capsaicin against chronic low-grade inflammation.

J Nutr Biochem 2018 Dec 21;65:101-114. Epub 2018 Dec 21.

School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China; Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address:

The combination of Puerariae Lobatae Radix (PLR) and Chuanxiong Rhizoma (CXR) is commonly used to treat cerebrovascular diseases. This work aimed to clarify the mechanisms of their action in treating cerebral ischemic stroke from the perspective of gut microecology. The PLR and CXR combination effectively improved the neurological function, reduced the cerebral infarction and relieved the complications of cerebral ischemic stroke, including dyslipidemia, increased blood viscosity and thrombotic risk. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2018.12.004DOI Listing
December 2018
3.794 Impact Factor

Fecal Microbiota of Toxigenic -Associated Diarrhea.

Front Microbiol 2018 14;9:3331. Epub 2019 Jan 14.

Hospital Universitario Río Hortega, Valladolid, Spain.

infection (CDI) is currently one of the most important causes of infectious diarrhea in developed countries and the main cause in healthcare settings. Here, we characterized the gut microbiota from the feces of 57 patients with diarrhea from nosocomial and community-acquired CDI. We performed an ecological analysis by high-throughput sequencing of the V3-V4 region of 16S rRNA amplicons and evaluated the association of the various ecological profiles with CDI risk factors. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341279PMC
January 2019
1 Read

Mixed Viral-Bacterial Infections and Their Effects on Gut Microbiota and Clinical Illnesses in Children.

Sci Rep 2019 Jan 29;9(1):865. Epub 2019 Jan 29.

Biomedical Research Center, Qatar University, Doha, 2713, Qatar.

Acute gastroenteritis remains a major cause of morbidity and mortality among young children worldwide. It accounts for approximately 1.34 million deaths annually in children younger than five years. Read More

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http://dx.doi.org/10.1038/s41598-018-37162-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351549PMC
January 2019
2 Reads
5.078 Impact Factor

The emergence of antimicrobial resistance in environmental strains of the Bacteroides fragilis group.

Environ Int 2019 Mar 22;124:408-419. Epub 2019 Jan 22.

Department of Environmental Microbiology, University of Warmia and Mazury in Olsztyn, Prawocheńskiego 1, 10-957 Olsztyn, Poland. Electronic address:

Anaerobic bacteria of the genus Bacteroides are a large group of commensal microorganisms that colonize the human and animal digestive tract. The genus Bacteroides and the closely related genus Parabacteroides include the Bacteroides fragilis group (BFG) of potentially pathogenic bacteria which are frequently isolated from patients with anaerobic infections. The aim of this study was to assess the antimicrobial resistance of environmental strains of the Bacteroides fragilis group. Read More

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http://dx.doi.org/10.1016/j.envint.2018.12.056DOI Listing
March 2019
1 Read

Prospective examination of the changes in the urinary microbiome induced by transrectal biopsy of the prostate using 16S rRNA gene analysis.

Prostate Cancer Prostatic Dis 2019 Jan 21. Epub 2019 Jan 21.

Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA.

Objectives: To prospectively examine the changes in microbiota within the urinary tract after transrectal prostate biopsy.

Materials And Methods: Data, urine, and fecal samples prospectively collected from 30 patients before and after transrectal biopsy of the prostate. DNA was extracted from urine collected after a prostate massage before and after prostate biopsy, and from fecal samples collected before the biopsy. Read More

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http://dx.doi.org/10.1038/s41391-018-0120-3DOI Listing
January 2019
1 Read

Bacteroides ovatus ATCC 8483 monotherapy is superior to traditional fecal transplant and multi-strain bacteriotherapy in a murine colitis model.

Gut Microbes 2019 Jan 21:1-17. Epub 2019 Jan 21.

a Pediatric Gastroenterology, Hepatology and Nutrition , Baylor College of Medicine, Texas Children's Hospital , Houston , TX , USA.

Background And Aims: Bacteriotherapy aimed at addressing dysbiosis may be therapeutic for Inflammatory Bowel Diseases (IBDs). We sought to determine if defined Bacteroides-based bacteriotherapy could be an effective and consistent alternative to fecal microbiota transplantation (FMT) in a murine model of IBD.

Methods: We induced experimental colitis in 8- 12-week-old C57BL/6 mice using 2-3% dextran sodium sulfate. Read More

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https://www.tandfonline.com/doi/full/10.1080/19490976.2018.1
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http://dx.doi.org/10.1080/19490976.2018.1560753DOI Listing
January 2019
3 Reads

Therapeutic uses of metronidazole and its side effects: an update.

Eur Rev Med Pharmacol Sci 2019 Jan;23(1):397-401

Área Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Circuito Ex Hacienda, Pachuca de Soto Hidalgo, México.

Objective: Metronidazole is an antibiotic widely used in different medical conditions such as trichomoniasis, amoebiasis, and giardiasis among others. Its use has been associated with toxicity; however, it is not well characterized. In this review, we discuss the different therapeutic uses of metronidazole and its side effects in order to aid future investigation in this field. Read More

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http://dx.doi.org/10.26355/eurrev_201901_16788DOI Listing
January 2019
3 Reads

Potential risk factors and outcomes of infection with multidrug resistance among diabetic patients having ulcers: 7 years study.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):414-418. Epub 2018 Oct 13.

Former Professor of Endocrinology and Dean, Faculty of Medicine, Ex-Director, Rajiv Gandhi Centre for Diabetes and Endocrinology, Former Dean, Faculty of Medicine, J.N. Medical College, Aligarh Muslim University, Aligarh, 202002, India; Consultant, Diabetes and Superspeciality Center, Central Tower Ground Floor, Kela Nagar Chauraha, Aligarh, 202002, India.

Diabetes Mellitus is characterized as a hyperglycemic condition, which results due to alteration in the secretion of insulin or action of insulin. The development and spread of microorganisms is known as a key health concern, and such cases are growing drastically in hospitals and communities. Therefore, the study aims to determine the potential risk factors and infection outcomes among diabetic patients with multi drug resistance, who are suffering from foot ulcerations. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.10.014DOI Listing
October 2018
2 Reads

Correlation between the diversity of vaginal microbiota and the risk of high-risk human papillomavirus infection.

Int J Gynecol Cancer 2019 Jan;29(1):28-34

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.

Objectives: Since other genital infections enhance HIV susceptibility by inducing inflammation and evidence suggests that the vaginal microbiome plays a functional role in the persistence or regression of high-risk human papillomavirus (HPV) infections, we investigated the relationship between the composition of the vaginal microbiota and the risk of high-risk HPV infection.

Methods: The study included 151 healthy women (65 HPV-positive and 86 HPV-negative) aged 20-65 at enrollment. Total genome DNA from samples was extracted using the hexadecyltrimethylammonium bromide (CTAB) CTAB method. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000032DOI Listing
January 2019

The respiratory microbiome and susceptibility to influenza virus infection.

PLoS One 2019 9;14(1):e0207898. Epub 2019 Jan 9.

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.

Influenza is a major cause of morbidity and mortality worldwide. However, vaccine effectiveness has been low to moderate in recent years and vaccine coverage remains low, especially in low- and middle-income countries. Supplementary methods of prevention should be explored to reduce the high burden of influenza. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207898PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326417PMC
January 2019
4 Reads

Prevents Infection in a Mouse Model by Restoring Gut Barrier and Microbiome Regulation.

Front Microbiol 2018 21;9:2976. Epub 2018 Dec 21.

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China.

is currently the leading cause of nosocomial infection. Antibiotics remain the first-line therapy for -associated diseases (CDAD), despite the risks of resistance promotion and further gut microbiota perturbation. Notably, the abundance of was reported to be significantly decreased in CDAD patients. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02976
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http://dx.doi.org/10.3389/fmicb.2018.02976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308121PMC
December 2018
1 Read

IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Infection.

J Immunol 2019 Feb 7;202(3):956-965. Epub 2019 Jan 7.

The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada;

The cytokine IL-22 is rapidly induced at barrier surfaces where it regulates host-protective antimicrobial immunity and tissue repair but can also enhance disease severity in some chronic inflammatory settings. Using the chronic gastroenteritis model, Ab-mediated neutralization of IL-22 impaired intestinal epithelial barrier integrity and, consequently, exaggerated expression of proinflammatory cytokines. As disease normally resolved, neutralization of IL-22 caused luminal narrowing of the cecum-a feature reminiscent of fibrotic strictures seen in Crohn disease patients. Read More

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1801308
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http://dx.doi.org/10.4049/jimmunol.1801308DOI Listing
February 2019
13 Reads

An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows.

Genomics Inform 2018 Dec 28;16(4):e21. Epub 2018 Dec 28.

Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.

Metritis, the inflammation of the uterus caused by polymicrobial infections, is a prevalent and costly disease to the dairy industry as it decreases milk yield, survival, and the welfare of dairy cows. Although the antibiotic ceftiofur is widely used for the treatment of metritis, endometrium and ovary function is compromised, resulting in subfertility and infertility. According to culture-dependent studies, uterine pathogens include Escherichia coli, Trueperella pyogenes, Fusobacterium necrophorum, and Prevotella melaninogenica. Read More

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http://dx.doi.org/10.5808/GI.2018.16.4.e21DOI Listing
December 2018

Composition of the intestinal microbiota in extended-spectrum β-lactamase-producing Enterobacteriaceae carriers and non-carriers in Thailand.

Int J Antimicrob Agents 2018 Dec 19. Epub 2018 Dec 19.

Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok-Noi, Bangkok 10700, Thailand. Electronic address:

There is increasing recognition that the intestinal microbiota govern human well-being and prevent diseases. Intestinal colonization by antibiotic-resistant pathogens, however, can lead to the spread of resistance as well as serious infections. Extended-spectrum β-lactamase producing Enterobacteriaceae (ESBL-E) represent particularly dangerous pathogens, which are known to asymptomatically colonize the intestinal tract in the community. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2018.12.006DOI Listing
December 2018

Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life.

Nat Microbiol 2018 Dec 17. Epub 2018 Dec 17.

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

The human gut microbiome matures towards the adult composition during the first years of life and is implicated in early immune development. Here, we investigate the effects of microbial genomic diversity on gut microbiome development using integrated early childhood data sets collected in the DIABIMMUNE study in Finland, Estonia and Russian Karelia. We show that gut microbial diversity is associated with household location and linear growth of children. Read More

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http://www.nature.com/articles/s41564-018-0321-5
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http://dx.doi.org/10.1038/s41564-018-0321-5DOI Listing
December 2018
22 Reads

The efficacy and safety of tazobactam/ceftolozane in combination with metronidazole in Japanese patients with complicated intra-abdominal infections.

J Infect Chemother 2019 Feb 6;25(2):111-116. Epub 2018 Dec 6.

Japan Development, MSD K.K., Tokyo, Japan. Electronic address:

Tazobactam/ceftolozane, a novel antimicrobial therapy, is active against Pseudomonas aeruginosa and most extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. We report the results of the efficacy and safety of tazobactam/ceftolozane in Japanese patients with complicated intra-abdominal infections (cIAI). A multicenter, open-label, noncomparative study (MK-7625A Protocol 013, ClinicalTrials. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.10.012DOI Listing
February 2019
1 Read

Airborne bacteria in a wastewater treatment plant: Emission characterization, source analysis and health risk assessment.

Water Res 2019 Feb 14;149:596-606. Epub 2018 Nov 14.

State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; National Engineering Laboratory for VOCs Pollution Control Material & Technology, University of Chinese Academy of Sciences, Beijing, 101408, China. Electronic address:

Wastewater treatment plants (WWTPs) are major sources of airborne bacteria, which could pose health risks to WWTP workers and surrounding residents. In this study, air samples were collected from various treatment facilities of a typical WWTP. Community compositions of airborne bacteria were identified by high-throughput sequencing technique. Read More

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http://dx.doi.org/10.1016/j.watres.2018.11.027DOI Listing
February 2019
6 Reads

Comparative genomics of transport proteins in seven Bacteroides species.

PLoS One 2018 5;13(12):e0208151. Epub 2018 Dec 5.

Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA, United States of America.

The communities of beneficial bacteria that live in our intestines, the gut microbiome, are important for the development and function of the immune system. Bacteroides species make up a significant fraction of the human gut microbiome, and can be probiotic and pathogenic, depending upon various genetic and environmental factors. These can cause disease conditions such as intra-abdominal sepsis, appendicitis, bacteremia, endocarditis, pericarditis, skin infections, brain abscesses and meningitis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208151PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281302PMC
December 2018
3 Reads

Effects of proton pump inhibitor on the human gut microbiome profile in multi-ethnic groups in Singapore.

Singapore Med J 2018 Nov 29. Epub 2018 Nov 29.

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

Introduction: The objectives of this study were to examine the effects of ethnicity, gender, and a proton pump inhibitor (PPI), omeprazole, on the human gut microbiome. PPIs are commonly used for the treatment of acid-related disorders. We hypothesised that PPI therapy might perturb microbial communities and alter the gut microbiome. Read More

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http://dx.doi.org/10.11622/smedj.2018152DOI Listing
November 2018
5 Reads

Polymerase Chain Reaction Assay Using the Restriction Fragment Length Polymorphism Technique in the Detection of Prosthetic Joint Infections: A Multi-Centered Study.

J Arthroplasty 2019 Feb 25;34(2):359-364. Epub 2018 Oct 25.

Department of Molecular Pathology, National Research Institute of Tuberculosis and Lung Diseases, Shahid Behshti University of Medical Sciences, Tehran, Iran; Department of Molecular Biology, Dr. Khosroshahi's Pathobiology Laboratory, Tehran, Iran.

Background: PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) techniques have been used for the diagnosis of bacteria in some infections. In this study, we aimed to evaluate the diagnostic accuracy of PCR for the diagnosis of prosthetic joint infections (PJI) and to identify isolated microorganisms, using the RFLP method.

Methods: During January 2015 to January 2018, patients who were suspected of having PJI after arthroplasty surgery or were candidates for revision surgery due to loosening of implant entered the study. Read More

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http://dx.doi.org/10.1016/j.arth.2018.10.017DOI Listing
February 2019
2 Reads

Rotavirus-mediated alteration of gut microbiota and its correlation with physiological characteristics in neonatal calves.

J Microbiol 2019 Feb 19;57(2):113-121. Epub 2018 Nov 19.

Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University, Iksan, 54596, Republic of Korea.

Diarrhea is a fatal disease to neonatal calves, and rotavirus is the main pathogen associated with neonatal calf diarrhea. Although previous studies have reported that the gut microbiota is changed in calves during diarrhea, less is known about whether rotavirus infection alters the structure of the gut microbiota. Here, we characterized fecal microbial communities and identified possible relationships between the gut microbiota profiles and physiological parameters. Read More

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http://link.springer.com/10.1007/s12275-019-8549-1
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http://dx.doi.org/10.1007/s12275-019-8549-1DOI Listing
February 2019
10 Reads

Omadacycline Gut Microbiome Exposure Does Not Induce Clostridium difficile Proliferation or Toxin Production in a Model That Simulates the Proximal, Medial, and Distal Human Colon.

Antimicrob Agents Chemother 2019 Feb 29;63(2). Epub 2019 Jan 29.

Leeds Institute of Biomedical and Clinical Sciences, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom

A clinically reflective model of the human colon was used to investigate the effects of the broad-spectrum antibiotic omadacycline on the gut microbiome and the subsequent potential to induce simulated infection (CDI). Triple-stage chemostat gut models were inoculated with pooled human fecal slurry from healthy volunteers (age, ≥60 years). Models were challenged twice with 10 CFU spores (PCR ribotype 027). Read More

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http://dx.doi.org/10.1128/AAC.01581-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355569PMC
February 2019
6 Reads

Antimicrobial Susceptibility Patterns of Anaerobic Bacterial Clinical Isolates From 2014 to 2016, Including Recently Named or Renamed Species.

Ann Lab Med 2019 Mar;39(2):190-199

Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea.

Background: Anaerobic bacterial resistance trends may vary across regions or institutions. Regional susceptibility patterns are pivotal in the empirical treatment of anaerobic infections. We determined the antimicrobial resistance patterns of clinically important anaerobic bacteria, including recently named or renamed anaerobes. Read More

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http://dx.doi.org/10.3343/alm.2019.39.2.190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240532PMC
March 2019
1 Read

Effects of the application of vitamin E and silicone dressings vs conventional dressings on incisional surgical site infection in elective laparoscopic colorectal surgery: a prospective randomized clinical trial.

J Hosp Infect 2018 Nov 3. Epub 2018 Nov 3.

Department of Surgery, Hospital Universitario de San Juan, Alicante, Spain.

Aim: To compare the effect of conventional wound dressings (CD) with vitamin E and silicone (E-Sil) dressings on incisional surgical site infection (SSI) in patients undergoing elective colorectal laparoscopic surgery.

Patients And Methods: A prospective, randomized study was performed. Patients were assigned at random into two groups: an E-Sil group and a CD group. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01956701183058
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http://dx.doi.org/10.1016/j.jhin.2018.10.021DOI Listing
November 2018
14 Reads

Repeated rectal application of a hyperosmolar lubricant is associated with microbiota shifts but does not affect PrEP drug concentrations: results from a randomized trial in men who have sex with men.

J Int AIDS Soc 2018 Oct;21(10):e25199

Division of Infectious Diseases, Department of Medicine, The Hope Clinic of the Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.

Introduction: Oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) is highly effective in preventing HIV infection among men who have sex with men (MSM). The effects of consistent personal lubricant use in the rectum on tissue PrEP drug concentrations and the rectal microbiota are unknown. We investigated rectal PrEP drug concentrations and the microbiota in MSM before and after repeated rectal application of a hyperosmolar lubricant. Read More

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http://doi.wiley.com/10.1002/jia2.25199
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http://dx.doi.org/10.1002/jia2.25199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207839PMC
October 2018
5 Reads
5.090 Impact Factor

Altered Gut Microbiota Composition in Subjects Infected With .

Front Microbiol 2018 28;9:2292. Epub 2018 Sep 28.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China.

Clonorchiasis is an infectious disease caused by helminths of (). The adult parasite mainly inhabits the bile duct and gall bladder, and results in various complications to the hepatobiliary system. The amount of bile secreted into the intestine is reduced in cases of infection, which may alter the pH of the gut and decrease the amount of surfactant protein D released from the gallbladder. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02292
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http://dx.doi.org/10.3389/fmicb.2018.02292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172334PMC
September 2018
10 Reads

Metronidazole resistance and nim genes in anaerobes: A review.

Anaerobe 2018 Oct 11;55:40-53. Epub 2018 Oct 11.

Hydrosciences Montpellier, CNRS, IRD, Univ Montpellier, Département de Microbiologie, CHU Nîmes, France. Electronic address:

Acquired resistance to metronidazole, a 5-nitroimidazole drug largely used worldwide in the empirical treatment of infections caused by anaerobes, is worrisome, especially since such resistance has been described in multidrug-resistant anaerobic bacteria. In anaerobes, acquired resistance to metronidazole may be due to a combination of various and complex mechanisms. Among them, nim genes, possibly located on mobile genetic elements, encode nitro-imidazole-reductases responsible for drug inactivation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10759964183017
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http://dx.doi.org/10.1016/j.anaerobe.2018.10.004DOI Listing
October 2018
27 Reads

Uselessness of microbiological samples in acute appendicitis with frank pus: to collect or not to collect?

Eur J Trauma Emerg Surg 2018 Oct 12. Epub 2018 Oct 12.

Department of Surgery, San Gerardo Hospital, University of Milan Bicocca, G.B. Pergolesi 33, Monza, Italy.

Introduction: Current use of antimicrobial therapy is prophylactic, empirical and broad spectrum. But, the age-old practice of obtaining cultures still remain. The aim of this study was to evaluate bacterial etiology and adequacy of antibiotic prophylaxis in patients diagnosed with acute appendicitis to help determine the utility of intraoperative cultures in guiding clinical decision-making. Read More

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http://dx.doi.org/10.1007/s00068-018-1031-7DOI Listing
October 2018
4 Reads

[Analysis on the distribution and drug resistance features of anaerobes isolated from clinical infectious specimens].

Zhonghua Yi Xue Za Zhi 2018 Sep;98(36):2894-2898

Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolian Medical University, Hohhot 010050, China.

To clarify distribution and drug resistance characteristics of anaerobes isolated from clinical infectious samples, and to provide experimental data for guiding on treatment of infections caused by anaerobes. The anaerobes, isolated from 1 057 different clinical specimens from inpatients admitted to the Affiliated Hospital of Inner Mongolia Medical University from March 2016 to November 2017, were identified by VITEK-2 anaerobes and corynebacterium (ANC) card and bacteroides fragilis isolates were further verified by 16S-rRNA sequencing. Meanwhile, broth dilution method was employed to detect the drug sensititities of and PCR method was used to detect the carbapenem resistance gene cfiA. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.36.004DOI Listing
September 2018
1 Read

Evaluation of blood culture broths with lysis buffer to directly identify specific pathogens by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry methods.

Infect Drug Resist 2018 24;11:1573-1579. Epub 2018 Sep 24.

Division of Infectious Diseases and Infection Control, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Miyagi, Japan,

Background: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is now widely used to detect pathogens in clinical settings in Japan.

Method: Here, we report the effects of adding lysis buffer in the MALDI-TOF MS method to directly detect bacteria from 3 blood culture systems and compare their detection efficiencies for each pathogen.

Results: Blood culture broths from BD, bioMérieux, and Oxoid showed similar detection efficiencies without lysis buffer use and , , and were efficiently detected in all broths when lysis buffer was used. Read More

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https://www.dovepress.com/evaluation-of-blood-culture-broths
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http://dx.doi.org/10.2147/IDR.S169197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159798PMC
September 2018
8 Reads

: A Novel Invertebrate Model to Distinguish Intestinal Symbionts From Pathobionts.

Front Immunol 2018 19;9:2114. Epub 2018 Sep 19.

Department for Medical Microbiology and Hygiene, Interfacultary Institute for Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.

Insects and mammals share evolutionary conserved innate immune responses to maintain intestinal homeostasis. We investigated whether the larvae of the greater wax moth may be used as an experimental organism to distinguish between symbiotic and pathobiotic , which are mammalian intestinal commensals. Oral application of the symbiont or pathobiont to resulted in clearly distinguishable innate immune responses that could be verified by analyzing similar innate immune components in mice and . Read More

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http://dx.doi.org/10.3389/fimmu.2018.02114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156133PMC
September 2018

Oral probiotic combination of Lactobacillus and Bifidobacterium alters the gastrointestinal microbiota during antibiotic treatment for Clostridium difficile infection.

PLoS One 2018 28;13(9):e0204253. Epub 2018 Sep 28.

Department of Medicine, Division of Infectious Disease, University of Wisconsin - Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America.

Perturbations in the gastrointestinal microbiome caused by antibiotics are a major risk factor for Clostridium difficile infection (CDI). Probiotics are often recommended to mitigate CDI symptoms; however, there exists only limited evidence showing probiotic efficacy for CDI. Here, we examined changes to the GI microbiota in a study population where probiotic treatment was associated with significantly reduced duration of CDI diarrhea. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204253PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161886PMC
September 2018
1 Read

Noncontiguous finished genome sequences and description of sp. nov., sp. nov., sp. nov., sp. nov., sp. nov. and sp. nov. identified by culturomics.

New Microbes New Infect 2018 Nov 21;26:73-88. Epub 2018 Jun 21.

Aix-Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France.

Culturomics is a concept developing different culture conditions in order to enlarge our knowledge of the human microbiota through the discovery of previously uncultured bacteria. This enabled us to isolate six new species of the genus: strain Marseille-P2644, strain Marseille-P2824, strain Marseille-P3166, strain Marseille-P3108, strain Marseille-P3208 and strain Marseille-P3132. Those bacteria are Gram-negative anaerobic bacilli. Read More

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http://dx.doi.org/10.1016/j.nmni.2018.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154776PMC
November 2018
1 Read

Masquelet technique for the treatment of acute osteomyelitis of the PIP joint caused by clenched-fist human bite injury: A case report.

Int J Surg Case Rep 2018 17;51:282-287. Epub 2018 Sep 17.

Department of Orthopedic Surgery, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan.

Introduction: The Masquelet technique is a well-known and efficient procedure for lower limb soft tissue reconstruction after severe osteomyelitis requiring bone excision. However, this technique is rarely used in the hand.

Presentation Of Case: The patient was 38-year-old man. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149196PMC
September 2018
2 Reads

Bacterial antagonism in host-associated microbial communities.

Science 2018 09;361(6408)

Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Antagonistic interactions are abundant in microbial communities and contribute not only to the composition and relative proportions of their members but also to the longer-term stability of a community. This Review will largely focus on bacterial antagonism mediated by ribosomally synthesized peptides and proteins produced by members of host-associated microbial communities. We discuss recent findings on their diversity, functions, and ecological impacts. Read More

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http://dx.doi.org/10.1126/science.aat2456DOI Listing
September 2018

Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria.

PLoS Pathog 2018 09 12;14(9):e1007191. Epub 2018 Sep 12.

Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Clostridium difficile is a Gram-positive spore-forming anaerobe and a major cause of antibiotic-associated diarrhoea. Disruption of the commensal microbiota, such as through treatment with broad-spectrum antibiotics, is a critical precursor for colonisation by C. difficile and subsequent disease. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135563PMC
September 2018
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Gut Microbiota in Human Immunodeficiency Virus-Infected Individuals Linked to Coronary Heart Disease.

J Infect Dis 2019 Jan;219(3):497-508

Clinic for Dermatology and Venerology, University of Duisburg-Essen.

Background: Human immunodeficiency virus (HIV) infection is an independent risk factor for coronary heart disease (CHD) and is associated with perturbation of the gut microbiota.

Methods: We analyzed gut microbiota in 30 HIV-infected individuals with CHD (CHD+) and 30 without CHD (CHD-) of the HIV-HEART study group.

Results: Gut microbiota linked to CHD was associated with lower α-diversity. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiy524DOI Listing
January 2019
20 Reads

Effects of mixed lactic acid bacteria on intestinal microbiota of mice infected with Staphylococcus aureus.

BMC Microbiol 2018 09 6;18(1):109. Epub 2018 Sep 6.

College of Food Science and Engineering, Jilin Agricultural University, Changchun, 130118, People's Republic of China.

Background: The stability of intestinal microorganisms plays an important role in human health, as the intestines perform important functions in the human body. Staphylococcus aureus is a Gram-positive, facultative anaerobic bacteria, it causes human infection worldwide, and is a major pathogen that causes intestinal infection. Mixed lactic acid bacteria (LAB) may have potential in the prevention and treatment of S. Read More

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http://dx.doi.org/10.1186/s12866-018-1245-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127954PMC
September 2018
4 Reads

Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection.

Mucosal Immunol 2019 01 31;12(1):232-246. Epub 2018 Aug 31.

irsiCaixa AIDS Research Institute, Ctra de Canyet s/n, Badalona, 08916, Catalonia, Spain.

Human immunodeficiency virus (HIV)-1 infection causes severe gut and systemic immune damage, but its effects on the gut microbiome remain unclear. Previous shotgun metagenomic studies in HIV-negative subjects linked low-microbial gene counts (LGC) to gut dysbiosis in diseases featuring intestinal inflammation. Using a similar approach in 156 subjects with different HIV-1 phenotypes, we found a strong, independent, dose-effect association between nadir CD4+ T-cell counts and LGC. Read More

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http://dx.doi.org/10.1038/s41385-018-0083-7DOI Listing
January 2019
13 Reads

Pharmacokinetics and Pharmacodynamics of Levornidazole in Patients With Intra-abdominal AnaerobicInfection.

Clin Ther 2018 Sep 23;40(9):1548-1555. Epub 2018 Aug 23.

Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Health and Family Planning Commission, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Purpose: The pharmacokinetic (PK) and pharmacodynamic characteristics of levornidazole were studied in patients with intra-abdominal anaerobic infection to provide the rationale of new clinical dosing regimen of levornidazole.

Methods: A single-center, open, multidose trial was conducted in 16 patients with intra-abdominal anaerobic infection. Patients received levornidazole at 500mg q12h by intravenous infusion for 3 to 7days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01492918183032
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http://dx.doi.org/10.1016/j.clinthera.2018.07.017DOI Listing
September 2018
9 Reads

Gut microbiota associated with pulmonary tuberculosis and dysbiosis caused by anti-tuberculosis drugs.

J Infect 2018 Aug 11. Epub 2018 Aug 11.

MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China ; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China; Shenzhen Engineering Center for Tuberculosis, Shenzhen Key Lab. of Infection & Immunity, Shenzhen Third People's Hospital, Shenzhen University, Shenzhen 518112, China. Electronic address:

Background: An improved understanding of the gut microbiota could lead to better strategies for the diagnosis, therapy and prophylaxis of tuberculosis (TB). The impact of both Mycobacterium tuberculosis (Mtb) infection and anti-TB treatment on the gut microbiota has rarely been studied.

Methods: We characterized the diversity and composition of the gut microbiota in pulmonary TB patients as well as the effects of anti-TB drugs on the gut microbiota. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.08.006DOI Listing
August 2018
7 Reads

Enhanced preservation of the human intestinal microbiota by ridinilazole, a novel Clostridium difficile-targeting antibacterial, compared to vancomycin.

PLoS One 2018 2;13(8):e0199810. Epub 2018 Aug 2.

Tufts Medical Center, Boston, MA, United States of America.

Ridinilazole, a novel targeted antibacterial being developed for the treatment of C. difficile infection (CDI) and prevention of recurrence, was shown in a recent Phase 2 study to be superior to vancomycin with regard to the primary efficacy measure, sustained clinical response (SCR), with the superiority being driven primarily by marked reductions in the rates of CDI recurrence within 30 days. Tolerability of ridinilazole was comparable to that of vancomycin. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199810PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071993PMC
January 2019

Acquisition of MACPF domain-encoding genes is the main contributor to LPS glycan diversity in gut Bacteroides species.

ISME J 2018 Dec 31;12(12):2919-2928. Epub 2018 Jul 31.

Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

The ability to antagonize competing strains and species is often important for bacterial fitness in microbial communities. The extent to which intra-species antagonism drives phenotypic diversity of bacterial species is rarely examined in a comprehensive manner at both the genetic and phenotypic levels. Here we show that for nine abundant human gut Bacteroides species examined, there are only a few LPS glycan genetic types. Read More

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http://dx.doi.org/10.1038/s41396-018-0244-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246601PMC
December 2018
3 Reads

A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection.

Cell Host Microbe 2018 08 26;24(2):296-307.e7. Epub 2018 Jul 26.

Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA. Electronic address:

The intestinal microbiota provides colonization resistance against pathogens, limiting pathogen expansion and transmission. These microbiota-mediated mechanisms were previously identified by observing loss of colonization resistance after antibiotic treatment or dietary changes, which severely disrupt microbiota communities. We identify a microbiota-mediated mechanism of colonization resistance against Salmonella enterica serovar Typhimurium (S. Read More

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http://dx.doi.org/10.1016/j.chom.2018.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223613PMC
August 2018
1 Read

Epidemiology, Microbiology and Antibiotic Sensitivity of Odontogenic Space Infections in Central India.

J Maxillofac Oral Surg 2018 Sep 11;17(3):324-331. Epub 2017 Apr 11.

4Department of Oral and Maxillofacial Surgery, Government College of Dentistry, Room No 3, Opposite M.Y Hospital, Indore, 452001 M.P India.

Introduction: Odontogenic infections are the most commonly encountered orofacial infections, which may spread into the adjacent anatomical spaces along the contiguous fascial planes, leading to involvement of multiple spaces which can progress to life-threatening situations.

Materials And Methods: A prospective study was carried out on 100 consecutive cases of odontogenic infections treated at our institute over a period of 18 months by surgical intervention and intravenous antibiotics. Morphologic study of the isolates and antibiotic sensitivity testing was performed. Read More

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http://dx.doi.org/10.1007/s12663-017-1014-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028331PMC
September 2018

In vitro activity of eravacycline and comparator antimicrobials against 143 recent strains of Bacteroides and Parabacteroides species.

Anaerobe 2018 Aug 4;52:122-124. Epub 2018 Jul 4.

R. M. Alden Research Laboratory, Santa Monica, CA, 90404, USA.

Eravacycline, a novel fluorocycline antibiotic, has been evaluated against complicated mixed aerobic/anaerobic intra-abdominal infections but scant supporting in vitro data against anaerobes has been published. We found that eravacycline had good anaerobic in vitro activity with MICs of 4 μg/ml or less against all Bacteroides and Parabacteroides strains tested, except for two B. ovatus strains that had MICs of 8 μg/ml and one strain that had an MIC of 16 μg/ml. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2018.06.016DOI Listing
August 2018
2 Reads

Probiotics in human gut microbiota can degrade host glycosaminoglycans.

Sci Rep 2018 Jul 13;8(1):10674. Epub 2018 Jul 13.

Laboratory of Basic and Applied Molecular Biotechnology, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan.

Glycosaminoglycans (GAGs) (e.g. heparin, chondroitin sulfate, and hyaluronan) show various significant physiological functions as a major component of extracellular matrix in animals. Read More

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http://www.nature.com/articles/s41598-018-28886-w
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http://dx.doi.org/10.1038/s41598-018-28886-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045597PMC
July 2018
19 Reads

Bloodstream infection caused by Bacteroides denticanum, a close relative of Bacteroides pyogenes, misidentified by MALDI TOF- mass spectrometry.

Anaerobe 2018 Dec 11;54:23-25. Epub 2018 Jul 11.

Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.

Bacteroides pyogenes can cause infections in humans. We describe a case of bloodstream infection caused by Bacteroides denticanum that probably originated from a dog bite. MALDI-TOF MS misidentified this new species as B. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2018.06.010DOI Listing
December 2018
3 Reads