5,809 results match your criteria Bacteroides Infection


Predicting clinical outcomes of cirrhosis patients with hepatic encephalopathy from the fecal microbiome.

Cell Mol Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taiwan; Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background & Aims: Gut dysbiosis plays a role in hepatic encephalopathy (HE), while its relationship at the acute episode of overt HE (AHE), the disease progression and clinical outcomes remains unclear. We aimed to identify AHE-specific microbiome and its association to patients' outcomes.

Methods: We profiled fecal microbiome changes for a cohort of 62 patients with cirrhosis and AHE i) before treatment, ii) 2-3 days after medication and iii) 2-3 months after recovery, and three control cohorts i) healthy individuals, patients with ii) compensated or iii) decompensated cirrhosis. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2019.04.008DOI Listing
April 2019
1 Read

Corrigendum: Prevents Infection in a Mouse Model by Restoring Gut Barrier and Microbiome Regulation.

Front Microbiol 2019 2;10:601. Epub 2019 Apr 2.

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China.

[This corrects the article DOI: 10.3389/fmicb.2018. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454232PMC

Infection prevalence and patterns in self-inflicted gunshot wounds to the face.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb 28. Epub 2019 Feb 28.

Head and Neck Institute, Portland, OR, USA.

Objective: Self-inflicted gunshot wounds (SIGSWs) to the craniomaxillofacial region are uncommon injuries but are associated with a high mortality rate. Therefore, treating these patients is a rare occurrence even in the largest trauma centers. As with many rare conditions, data specifically addressing this injury pattern are scarce. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.02.022DOI Listing
February 2019

Isolation and culture of Methanobrevibacter smithii by co-culture with hydrogen-producing bacteria on agar plates.

Clin Microbiol Infect 2019 Apr 12. Epub 2019 Apr 12.

Aix Marseille Univ, IRD, APHM, MEPHI, IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385, Marseille cedex 05, France. Electronic address:

Objective: Methanogenic archaea are considered as extremely oxygen-sensitive organisms and their culture is fastidious, requiring specific equipment. We report here the conditions allowing the cultivation of M. smithii in an anaerobic chamber without hydrogen addition. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.04.008DOI Listing

Use of bioengineered human commensal gut bacteria-derived microvesicles for mucosal plague vaccine delivery and immunization.

Clin Exp Immunol 2019 Apr 15. Epub 2019 Apr 15.

Gut Microbes and Health Research Programme, Quadram Institute Bioscience, Norwich, UK.

Plague caused by the Gram-negative bacterium, Yersinia pestis, is still endemic in parts of the world today. Protection against pneumonic plague is essential to prevent the development and spread of epidemics. Despite this, there are currently no licensed plague vaccines in the western world. Read More

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http://dx.doi.org/10.1111/cei.13301DOI Listing
April 2019
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Corrigendum to "'' sp. nov., a new human-associated bacterium isolated from ileum specimen".

New Microbes New Infect 2019 May 6;29:100523. Epub 2019 Mar 6.

Aix-Marseille Université, URMITE, UM63, CNRS7278, IRD198, Inserm 1095, Institut Hospitalo-Universitaire Méditerranée-Infection, Faculté de médecine, Marseille, France.

[This corrects the article DOI: 10.1016/j.nmni. Read More

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http://dx.doi.org/10.1016/j.nmni.2019.100523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434513PMC

A Galleria mellonella Oral Administration Model to Study Commensal-Induced Innate Immune Responses.

J Vis Exp 2019 Mar 21(145). Epub 2019 Mar 21.

Department for Medical Microbiology, Hygiene, Interfacultary Institute for Microbiology, Infection Medicine, University of Tübingen;

The investigation of the immunogenic potential of commensal bacteria on the host immune system is one essential component when studying intestinal host-microbe interactions. It is well established that different commensals exhibit a different potential to stimulate the host intestinal immune system. Such investigations involve vertebrate animals, especially rodents. Read More

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http://dx.doi.org/10.3791/59270DOI Listing
March 2019
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Anti-biofilm and antimicrobial effects of zerumbone against Bacteroides fragilis.

Anaerobe 2019 Apr 4;57:99-106. Epub 2019 Apr 4.

Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan, 31538, Republic of Korea; Department of Medical Sciences, College of Medical Sciences, Soonchunhyang University, Asan, 31538, Republic of Korea. Electronic address:

Enterotoxigenic Bacteroides fragilis (ETBF) can form biofilms in the colon mucosal membrane and may promote chronic infection and tumor formation. The objective of this study was to determine the effect of zerumbone extracted from Zingiber zerumbet (L.) Smith, on B. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.04.001DOI Listing

Antimicrobial susceptibilities of clinical isolates of the anaerobic bacteria which can cause aspiration pneumonia.

Anaerobe 2019 Apr 2;57:86-89. Epub 2019 Apr 2.

Department of Infection Control and Prevention, Aichi Medical University Hospital, Aichi, Japan; Department of Clinical Infectious Diseases, Aichi Medical University Graduate School of Medicine, Aichi, Japan. Electronic address:

Aspiration pneumonia is an infectious disease of the lungs caused by inhalation of saliva or foods, associated with swallowing dysfunction. Therefore, the major causative organisms are oral or gastric bacteria. In this study, we evaluated the antimicrobial susceptibility patterns of the anaerobic bacteria which can cause aspiration pneumonia, Fusobacterium spp. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.04.002DOI Listing
April 2019
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Identification of Three Types of Integrative and Conjugative Elements in Elizabethkingia anophelis Strains Isolated from around the World.

mSphere 2019 04 3;4(2). Epub 2019 Apr 3.

Biology Department, New Mexico State University, Las Cruces, New Mexico, USA.

is an emerging global multidrug-resistant opportunistic pathogen. We assessed the diversity among 13 complete genomes and 23 draft genomes of strains derived from various environmental settings and human infections from different geographic regions around the world from 1950s to the present. Putative integrative and conjugative elements (ICEs) were identified in 31/36 (86. Read More

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http://dx.doi.org/10.1128/mSphere.00040-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449604PMC
April 2019
1 Read

Prevalence of cases of amebic liver abscess in a tertiary care centre in India: A study on risk factors, associated microflora and strain variation of Entamoeba histolytica.

PLoS One 2019 3;14(4):e0214880. Epub 2019 Apr 3.

Department of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P., India.

Background: Amebiasis, caused by Entamoeba histolytica (E. histolytica), is a significant cause of morbidity and mortality in developing countries. Mortality due to amebiasis is mostly by extra intestinal infections, amebic liver abscess being the most common one. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214880PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447230PMC
April 2019
3 Reads

Gut Microbiota in Patients With Irritable Bowel Syndrome-a Systematic Review.

Gastroenterology 2019 Mar 30. Epub 2019 Mar 30.

Department of Medicine, Division of Gastroenterology & Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada. Electronic address:

Background & Aims: Irritable bowel syndrome (IBS) is common but difficult to treat. Altering the gut microbiota has been proposed as a strategy for treatment of IBS, but the association between the gut microbiome and IBS symptoms has not been well established. We performed a systematic review to explore evidence for this association. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.03.049DOI Listing
March 2019
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Short-term culture for rapid identification of anaerobic bacteria from blood cultures.

Anaerobe 2019 Mar 26;57:59-62. Epub 2019 Mar 26.

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Microbiology, Karolinska University Hospital, Huddinge, Sweden. Electronic address:

Identification of anaerobic bacteria causing blood stream infections (BSI) is challenging. This study describes the epidemiology of anaerobic BSI at a tertiary care hospital and the performance of a rapid method for identification of anaerobic bacteria from blood cultures over three years, between June 2015 and June 2018. Short-term culturing is a low-cost user-friendly method and may be used for rapid identification of bacteria from positive blood cultures by matrix-associated laser desorption ionization time of flight (MALDI-TOF). Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.03.014DOI Listing

Effects of wild blueberry (Vaccinium angustifolium) pomace feeding on gut microbiota and blood metabolites in free-range pastured broiler chickens.

Poult Sci 2019 Mar 28. Epub 2019 Mar 28.

Guelph Research and Development Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, ON N1G 5C9, Canada.

There is a need to develop cost-effective approaches to modulate gut microbiota, promote bird health, and prevent infections in pasture-raised broiler chickens. The present study evaluated the efficacy of organic wild blueberry (Vaccinium angustifolium) also called low-bush blueberry pomace (LBBP)-supplemented feed to modulate the chicken gut microbiota, and blood metabolites in order to improve bird health and productivity. Slow-growing broiler chickens were reared on pasture up to 64 D for sampling after 2 wk of treatment during brooding with 0, 1, and 2% LBBP in feed. Read More

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http://dx.doi.org/10.3382/ps/pez062DOI Listing
March 2019
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Inhibition of enterohemorrhagic O157:H7 infection in a gnotobiotic mouse model with pre-colonization by strains.

Biomed Rep 2019 Mar 7;10(3):175-182. Epub 2019 Feb 7.

Department of Animal Microbiology, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 980-8577, Japan.

Enterohemorrhagic (EHEC) O157:H7 has been known to cause outbreaks of hemorrhagic colitis and hemolytic uremic syndrome. We previously demonstrated that intestinal flora contribute to the prevention of EHEC infection in a mouse model. However, it has not yet been determined whether , a predominant genus in the human intestine, contributes to the prevention of EHEC infection. Read More

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http://dx.doi.org/10.3892/br.2019.1193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403472PMC
March 2019
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Oral Administration of Bovine Lactoferrin-Derived Lactoferricin (Lfcin) B Could Attenuate Enterohemorrhagic Escherichia coli O157:H7 Induced Intestinal Disease through Improving Intestinal Barrier Function and Microbiota.

J Agric Food Chem 2019 Apr 28;67(14):3932-3945. Epub 2019 Mar 28.

Key Laboratory of Tropical Biological Resources of Ministry of Education , Haikou , Hainan 570228 , People's Republic of China.

Lactoferricin (Lfcin) B, derived from lactoferrin in whey, has attracted considerable attention because of its multiple biological functions. Zoonotic enterohemorrhagic Escherichia coli (EHEC) O157:H7 has adverse effects on intestinal epithelial barrier function, leading to serious intestinal disease. In this study, the EHEC O157:H7-induced intestinal dysfunction model was developed to investigate the effects of Lfcin B on EHEC O157:H7-induced epithelial barrier disruption and microbiota dysbiosis. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b00861DOI Listing

Bacteroides Spp. Blebitis, Keratitis, and Endophthalmitis Following Uncomplicated Trabeculectomy.

J Glaucoma 2019 Mar 6. Epub 2019 Mar 6.

University of Alabama at Birmingham Callahan Eye Hospital, Birmingham, USA.

Purpose: To describe the first known case of Bacteroides spp. related blebitis, keratitis, and endophthalmitis following uncomplicated trabeculectomy METHODS:: Case report and literature review CASE: A: 63-year-old immunocompetent white male underwent uncomplicated trabeculectomy of his right eye. Two weeks later, a blebitis with adjacent keratitis was diagnosed, progressing over several days to endophthalmitis despite hourly topical fortified antibiotic therapy. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001235DOI Listing

Emergence of Carbapenem Resistance in Bacteroides fragilis in China.

Int J Antimicrob Agents 2019 Mar 1. Epub 2019 Mar 1.

Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, National Health and Family Planning Commission, Shanghai, China. Electronic address:

The antimicrobial resistance crisis makes it critically important for laboratories to closely monitor trends and mechanisms of emerging antimicrobial resistance in clinical isolates. Bacteroides fragilis is an anaerobic pathogen that causes several serious infections and is increasingly resistant to antimicrobials. However, data from China regarding antimicrobial resistance in B. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.02.017DOI Listing
March 2019
4 Reads

Surgical Site Infection in Endometriosis Surgery Is a Rare Complication: Results of a Single Center's Prospective Surveillance of Eight Hundred Ninety-Six Procedures.

Surg Infect (Larchmt) 2019 Feb 28. Epub 2019 Feb 28.

1 Department of Epidemiology and Public Health, Rouen University Hospital, Rouen, France.

Background: There are no studies reporting the rate of surgical site infection (SSI) after surgery for endometriosis, although this information is valuable when discussing the most appropriate treatment strategy with the patient.

Methods: We conducted a prospective cohort study in a university hospital and regional reference center for endometriosis. We sought to measure the rate of SSI after endometriosis surgery using prospective SSI post-discharge surveillance data and the hospital information system via an ad hoc algorithm using both diagnosis and procedure code classifications. Read More

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http://dx.doi.org/10.1089/sur.2018.209DOI Listing
February 2019
3 Reads

Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent infection.

Gut 2019 Feb 11. Epub 2019 Feb 11.

Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.

Objective: Faecal microbiota transplant (FMT) effectively treats recurrent infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect germination or vegetative growth. We hypothesised that loss of gut microbiota-derived bile salt hydrolases (BSHs) predisposes to CDI by perturbing gut bile metabolism, and that BSH restitution is a key mediator of FMT's efficacy in treating the condition. Read More

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http://dx.doi.org/10.1136/gutjnl-2018-317842DOI Listing
February 2019
2 Reads

Microbiome Diversity in Sputum of Nontuberculous Mycobacteria Infected Women with a History of Breast Cancer.

Cell Physiol Biochem 2019 28;52(2):263-279. Epub 2019 Feb 28.

Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, USA,

Background/aims: The nontuberculous mycobacterial lung disease (NTM), caused by Mycobacterium avium complex (MAC) is an increasing health problem in the USA and worldwide. The NTM disease is prevalent in Caucasian women with a current diagnosis or history of breast cancer (BCa), posing a significant challenge towards treatment. We hypothesize that NTM affected women with considerable therapeutic resistance may harbor pathogenic microbes other than nontuberculous mycobacterium, aiding in disease progression and therapeutic resistance. Read More

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http://dx.doi.org/10.33594/000000020DOI Listing

Antimicrobial Stewardship Opportunities in Patients with Bacteremia Not Identified by BioFire® FilmArray.

J Clin Microbiol 2019 Feb 27. Epub 2019 Feb 27.

Huntington Hospital, Pasadena, CA, USA.

A subset of bacteremia cases are caused by organisms not detected by the rapid diagnostics platform, BioFire® blood culture identification (BCID) with unknown clinical characteristics and outcomes. Patients with ≥1 positive blood culture over a 15-month period were grouped by Negative (NB-PC) vs. Positive BioFire® BCID (PB-PC) results and compared on demographics, infection characteristics, antibiotic therapy and outcomes (length of hospital stay (LOS) and in-hospital mortality). Read More

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http://jcm.asm.org/lookup/doi/10.1128/JCM.01941-18
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http://dx.doi.org/10.1128/JCM.01941-18DOI Listing
February 2019
6 Reads

Cuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic .

MBio 2019 02 26;10(1). Epub 2019 Feb 26.

Department of Pathology, Microbiology, and Immunology and the Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Enterohemorrhagic (EHEC) is a major cause of foodborne gastrointestinal illness. EHEC uses a specialized type III secretion system (T3SS) to form attaching and effacing lesions in the colonic epithelium and outcompete commensal gut microbiota to cause disease. A recent report in (E. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.00115-19
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http://dx.doi.org/10.1128/mBio.00115-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391915PMC
February 2019
5 Reads

The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole.

PLoS One 2019 26;14(2):e0212593. Epub 2019 Feb 26.

Division of Translational Medicine, New York University School of Medicine, New York, NY, United States of America.

Background: Chagas disease is still prevalent in rural areas of South America. In endemic areas of Bolivia, school children are screened for the program of Chagas disease eradication of the Ministry of Health, and positive children are treated. Here, we compared the fecal, oral and skin microbiomes of children with or without Chagas disease, and before and after benznidazol treatment of infected children. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212593PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391005PMC
February 2019
1 Read

meningitis in a Saudi infant: case report and literature review.

Int J Pediatr Adolesc Med 2018 Sep 18;5(3):122-126. Epub 2018 Sep 18.

Children Specialized Hospital, King Fahad Medical City, Saudi Arabia.

Background: Anaerobic meningitis is mainly caused by and it is rarely detected in children. Few cases have been reported and there is usually an underlying cause. The timing of early recognition is crucial because any delay in the diagnosis and initiation of appropriate antimicrobial therapy has a devastating outcome. Read More

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http://dx.doi.org/10.1016/j.ijpam.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363260PMC
September 2018
1 Read

Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates.

Clin Microbiol Infect 2019 Feb 22. Epub 2019 Feb 22.

University of Groningen, University Medical Centre Groningen, Department of Medical Microbiology and Infection Prevention, Groningen, the Netherlands.

Objectives: The prevalence of resistance genes in two important anaerobic genera, Bacteroides and Prevotella, was assessed by applying PCR specifically directed to genes of interest.

Methods: A total of 101 Bacteroides spp. and 99 Prevotella spp. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.017DOI Listing
February 2019

Identification of PGN_1123 as the gene encoding lipid A deacylase, an enzyme required for Toll-like receptor 4 evasion, in .

J Bacteriol 2019 Feb 19. Epub 2019 Feb 19.

Department of Periodontics, School of Dentistry, University of Washington, PO Box 357444, Seattle WA 98195, USA.

Removal of one acyl chain from bacterial lipid A by deacylase activity is a mechanism used by many pathogenic bacteria to evade the host's Toll-like receptor 4 (TLR4)-mediated innate immune response. In , a periodontal pathogen, lipid A deacylase activity converts a majority of the initially synthesized penta-acylated lipid A, a TLR4 agonist, to tetra-acylated structures, which effectively evade TLR4 sensing by being either inert or antagonistic at TLR4. In this paper, we report successful identification of the gene that encodes the lipid A deacylase enzyme. Read More

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http://dx.doi.org/10.1128/JB.00683-18DOI Listing
February 2019

Two Strains of Effectively Decrease the Colonization of VRE in a Mouse Model.

Front Cell Infect Microbiol 2019 30;9. Epub 2019 Jan 30.

State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention - Chinese Center for Disease Control and Prevention, Beijing, China.

(VRE) infection is a serious challenge for clinical management and there is no effective treatment at present. Fecal microbiota transplantation (FMT) and probiotic intervention have been shown to be promising approaches for reducing the colonization of certain pathogenic bacteria in the gastrointestinal tract, however, no such studies have been done on VRE. In this study, we evaluated the effect of FMT and two strains (Y74 and HT121) on the colonization of VRE in a VRE-infection mouse model. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00006
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http://dx.doi.org/10.3389/fcimb.2019.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363661PMC
January 2019
1 Read

Dynamics of the Gut Microbiota in Children Receiving Selective or Total Gut Decontamination Treatment during Hematopoietic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2019 Feb 5. Epub 2019 Feb 5.

Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands; Center for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, the Netherlands.

Bloodstream infections and graft-versus-host disease are common complications after hematopoietic stem cell transplantation (HSCT) procedures, associated with the gut microbiota that acts as a reservoir for opportunistic pathogens. Selective gut decontamination (SGD) and total gut decontamination (TGD) during HSCT have been associated with a decreased risk of developing these complications after transplantation. However, because studies have shown conflicting results, the use of these treatments remains subject of debate. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.01.037DOI Listing
February 2019
2 Reads

Puerariae Lobatae Radix with chuanxiong Rhizoma for treatment of cerebral ischemic stroke by remodeling gut microbiota to regulate the brain-gut barriers.

J Nutr Biochem 2019 Mar 21;65:101-114. Epub 2018 Dec 21.

School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China; Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address:

The combination of Puerariae Lobatae Radix (PLR) and Chuanxiong Rhizoma (CXR) is commonly used to treat cerebrovascular diseases. This work aimed to clarify the mechanisms of their action in treating cerebral ischemic stroke from the perspective of gut microecology. The PLR and CXR combination effectively improved the neurological function, reduced the cerebral infarction and relieved the complications of cerebral ischemic stroke, including dyslipidemia, increased blood viscosity and thrombotic risk. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2018.12.004DOI Listing
March 2019
1 Read
3.794 Impact Factor

Fecal Microbiota of Toxigenic -Associated Diarrhea.

Front Microbiol 2018 14;9:3331. Epub 2019 Jan 14.

Hospital Universitario Río Hortega, Valladolid, Spain.

infection (CDI) is currently one of the most important causes of infectious diarrhea in developed countries and the main cause in healthcare settings. Here, we characterized the gut microbiota from the feces of 57 patients with diarrhea from nosocomial and community-acquired CDI. We performed an ecological analysis by high-throughput sequencing of the V3-V4 region of 16S rRNA amplicons and evaluated the association of the various ecological profiles with CDI risk factors. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341279PMC
January 2019
1 Read

Mixed Viral-Bacterial Infections and Their Effects on Gut Microbiota and Clinical Illnesses in Children.

Sci Rep 2019 Jan 29;9(1):865. Epub 2019 Jan 29.

Biomedical Research Center, Qatar University, Doha, 2713, Qatar.

Acute gastroenteritis remains a major cause of morbidity and mortality among young children worldwide. It accounts for approximately 1.34 million deaths annually in children younger than five years. Read More

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http://dx.doi.org/10.1038/s41598-018-37162-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351549PMC
January 2019
3 Reads
5.078 Impact Factor

The emergence of antimicrobial resistance in environmental strains of the Bacteroides fragilis group.

Environ Int 2019 Mar 22;124:408-419. Epub 2019 Jan 22.

Department of Environmental Microbiology, University of Warmia and Mazury in Olsztyn, Prawocheńskiego 1, 10-957 Olsztyn, Poland. Electronic address:

Anaerobic bacteria of the genus Bacteroides are a large group of commensal microorganisms that colonize the human and animal digestive tract. The genus Bacteroides and the closely related genus Parabacteroides include the Bacteroides fragilis group (BFG) of potentially pathogenic bacteria which are frequently isolated from patients with anaerobic infections. The aim of this study was to assess the antimicrobial resistance of environmental strains of the Bacteroides fragilis group. Read More

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http://dx.doi.org/10.1016/j.envint.2018.12.056DOI Listing
March 2019
2 Reads

Prospective examination of the changes in the urinary microbiome induced by transrectal biopsy of the prostate using 16S rRNA gene analysis.

Prostate Cancer Prostatic Dis 2019 Jan 21. Epub 2019 Jan 21.

Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA.

Objectives: To prospectively examine the changes in microbiota within the urinary tract after transrectal prostate biopsy.

Materials And Methods: Data, urine, and fecal samples prospectively collected from 30 patients before and after transrectal biopsy of the prostate. DNA was extracted from urine collected after a prostate massage before and after prostate biopsy, and from fecal samples collected before the biopsy. Read More

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http://dx.doi.org/10.1038/s41391-018-0120-3DOI Listing
January 2019
1 Read

Bacteroides ovatus ATCC 8483 monotherapy is superior to traditional fecal transplant and multi-strain bacteriotherapy in a murine colitis model.

Gut Microbes 2019 Jan 21:1-17. Epub 2019 Jan 21.

a Pediatric Gastroenterology, Hepatology and Nutrition , Baylor College of Medicine, Texas Children's Hospital , Houston , TX , USA.

Background And Aims: Bacteriotherapy aimed at addressing dysbiosis may be therapeutic for Inflammatory Bowel Diseases (IBDs). We sought to determine if defined Bacteroides-based bacteriotherapy could be an effective and consistent alternative to fecal microbiota transplantation (FMT) in a murine model of IBD.

Methods: We induced experimental colitis in 8- 12-week-old C57BL/6 mice using 2-3% dextran sodium sulfate. Read More

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https://www.tandfonline.com/doi/full/10.1080/19490976.2018.1
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http://dx.doi.org/10.1080/19490976.2018.1560753DOI Listing
January 2019
3 Reads

Therapeutic uses of metronidazole and its side effects: an update.

Eur Rev Med Pharmacol Sci 2019 Jan;23(1):397-401

Área Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Circuito Ex Hacienda, Pachuca de Soto Hidalgo, México.

Objective: Metronidazole is an antibiotic widely used in different medical conditions such as trichomoniasis, amoebiasis, and giardiasis among others. Its use has been associated with toxicity; however, it is not well characterized. In this review, we discuss the different therapeutic uses of metronidazole and its side effects in order to aid future investigation in this field. Read More

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http://dx.doi.org/10.26355/eurrev_201901_16788DOI Listing
January 2019
4 Reads

Potential risk factors and outcomes of infection with multidrug resistance among diabetic patients having ulcers: 7 years study.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):414-418. Epub 2018 Oct 13.

Former Professor of Endocrinology and Dean, Faculty of Medicine, Ex-Director, Rajiv Gandhi Centre for Diabetes and Endocrinology, Former Dean, Faculty of Medicine, J.N. Medical College, Aligarh Muslim University, Aligarh, 202002, India; Consultant, Diabetes and Superspeciality Center, Central Tower Ground Floor, Kela Nagar Chauraha, Aligarh, 202002, India.

Diabetes Mellitus is characterized as a hyperglycemic condition, which results due to alteration in the secretion of insulin or action of insulin. The development and spread of microorganisms is known as a key health concern, and such cases are growing drastically in hospitals and communities. Therefore, the study aims to determine the potential risk factors and infection outcomes among diabetic patients with multi drug resistance, who are suffering from foot ulcerations. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.10.014DOI Listing
October 2018
4 Reads

Correlation between the diversity of vaginal microbiota and the risk of high-risk human papillomavirus infection.

Int J Gynecol Cancer 2019 Jan;29(1):28-34

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.

Objectives: Since other genital infections enhance HIV susceptibility by inducing inflammation and evidence suggests that the vaginal microbiome plays a functional role in the persistence or regression of high-risk human papillomavirus (HPV) infections, we investigated the relationship between the composition of the vaginal microbiota and the risk of high-risk HPV infection.

Methods: The study included 151 healthy women (65 HPV-positive and 86 HPV-negative) aged 20-65 at enrollment. Total genome DNA from samples was extracted using the hexadecyltrimethylammonium bromide (CTAB) CTAB method. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000032DOI Listing
January 2019

The respiratory microbiome and susceptibility to influenza virus infection.

PLoS One 2019 9;14(1):e0207898. Epub 2019 Jan 9.

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.

Influenza is a major cause of morbidity and mortality worldwide. However, vaccine effectiveness has been low to moderate in recent years and vaccine coverage remains low, especially in low- and middle-income countries. Supplementary methods of prevention should be explored to reduce the high burden of influenza. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207898PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326417PMC
January 2019
4 Reads

Prevents Infection in a Mouse Model by Restoring Gut Barrier and Microbiome Regulation.

Front Microbiol 2018 21;9:2976. Epub 2018 Dec 21.

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China.

is currently the leading cause of nosocomial infection. Antibiotics remain the first-line therapy for -associated diseases (CDAD), despite the risks of resistance promotion and further gut microbiota perturbation. Notably, the abundance of was reported to be significantly decreased in CDAD patients. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02976
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http://dx.doi.org/10.3389/fmicb.2018.02976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308121PMC
December 2018
1 Read

IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Infection.

J Immunol 2019 Feb 7;202(3):956-965. Epub 2019 Jan 7.

The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada;

The cytokine IL-22 is rapidly induced at barrier surfaces where it regulates host-protective antimicrobial immunity and tissue repair but can also enhance disease severity in some chronic inflammatory settings. Using the chronic gastroenteritis model, Ab-mediated neutralization of IL-22 impaired intestinal epithelial barrier integrity and, consequently, exaggerated expression of proinflammatory cytokines. As disease normally resolved, neutralization of IL-22 caused luminal narrowing of the cecum-a feature reminiscent of fibrotic strictures seen in Crohn disease patients. Read More

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1801308
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http://dx.doi.org/10.4049/jimmunol.1801308DOI Listing
February 2019
17 Reads

An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows.

Genomics Inform 2018 Dec 28;16(4):e21. Epub 2018 Dec 28.

Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.

Metritis, the inflammation of the uterus caused by polymicrobial infections, is a prevalent and costly disease to the dairy industry as it decreases milk yield, survival, and the welfare of dairy cows. Although the antibiotic ceftiofur is widely used for the treatment of metritis, endometrium and ovary function is compromised, resulting in subfertility and infertility. According to culture-dependent studies, uterine pathogens include Escherichia coli, Trueperella pyogenes, Fusobacterium necrophorum, and Prevotella melaninogenica. Read More

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http://dx.doi.org/10.5808/GI.2018.16.4.e21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440669PMC
December 2018

Composition of the intestinal microbiota in extended-spectrum β-lactamase-producing Enterobacteriaceae carriers and non-carriers in Thailand.

Int J Antimicrob Agents 2019 Apr 20;53(4):435-441. Epub 2018 Dec 20.

Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

There is increasing recognition that the intestinal microbiota govern human well-being and prevent diseases. Intestinal colonization by antibiotic-resistant pathogens, however, can lead to the spread of resistance as well as serious infections. Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) represent particularly dangerous pathogens, which are known to asymptomatically colonize the intestinal tract in the community. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2018.12.006DOI Listing

Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life.

Nat Microbiol 2019 Mar 17;4(3):470-479. Epub 2018 Dec 17.

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

The human gut microbiome matures towards the adult composition during the first years of life and is implicated in early immune development. Here, we investigate the effects of microbial genomic diversity on gut microbiome development using integrated early childhood data sets collected in the DIABIMMUNE study in Finland, Estonia and Russian Karelia. We show that gut microbial diversity is associated with household location and linear growth of children. Read More

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http://www.nature.com/articles/s41564-018-0321-5
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http://dx.doi.org/10.1038/s41564-018-0321-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384140PMC
March 2019
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The efficacy and safety of tazobactam/ceftolozane in combination with metronidazole in Japanese patients with complicated intra-abdominal infections.

J Infect Chemother 2019 Feb 6;25(2):111-116. Epub 2018 Dec 6.

Japan Development, MSD K.K., Tokyo, Japan. Electronic address:

Tazobactam/ceftolozane, a novel antimicrobial therapy, is active against Pseudomonas aeruginosa and most extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. We report the results of the efficacy and safety of tazobactam/ceftolozane in Japanese patients with complicated intra-abdominal infections (cIAI). A multicenter, open-label, noncomparative study (MK-7625A Protocol 013, ClinicalTrials. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.10.012DOI Listing
February 2019
4 Reads

Airborne bacteria in a wastewater treatment plant: Emission characterization, source analysis and health risk assessment.

Water Res 2019 02 14;149:596-606. Epub 2018 Nov 14.

State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; National Engineering Laboratory for VOCs Pollution Control Material & Technology, University of Chinese Academy of Sciences, Beijing, 101408, China. Electronic address:

Wastewater treatment plants (WWTPs) are major sources of airborne bacteria, which could pose health risks to WWTP workers and surrounding residents. In this study, air samples were collected from various treatment facilities of a typical WWTP. Community compositions of airborne bacteria were identified by high-throughput sequencing technique. Read More

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http://dx.doi.org/10.1016/j.watres.2018.11.027DOI Listing
February 2019
8 Reads

Comparative genomics of transport proteins in seven Bacteroides species.

PLoS One 2018 5;13(12):e0208151. Epub 2018 Dec 5.

Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA, United States of America.

The communities of beneficial bacteria that live in our intestines, the gut microbiome, are important for the development and function of the immune system. Bacteroides species make up a significant fraction of the human gut microbiome, and can be probiotic and pathogenic, depending upon various genetic and environmental factors. These can cause disease conditions such as intra-abdominal sepsis, appendicitis, bacteremia, endocarditis, pericarditis, skin infections, brain abscesses and meningitis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208151PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281302PMC
December 2018
4 Reads

Effects of proton pump inhibitor on the human gut microbiome profile in multi-ethnic groups in Singapore.

Singapore Med J 2018 Nov 29. Epub 2018 Nov 29.

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

Introduction: The objectives of this study were to examine the effects of ethnicity, gender, and a proton pump inhibitor (PPI), omeprazole, on the human gut microbiome. PPIs are commonly used for the treatment of acid-related disorders. We hypothesised that PPI therapy might perturb microbial communities and alter the gut microbiome. Read More

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http://dx.doi.org/10.11622/smedj.2018152DOI Listing
November 2018
6 Reads

Polymerase Chain Reaction Assay Using the Restriction Fragment Length Polymorphism Technique in the Detection of Prosthetic Joint Infections: A Multi-Centered Study.

J Arthroplasty 2019 02 25;34(2):359-364. Epub 2018 Oct 25.

Department of Molecular Pathology, National Research Institute of Tuberculosis and Lung Diseases, Shahid Behshti University of Medical Sciences, Tehran, Iran; Department of Molecular Biology, Dr. Khosroshahi's Pathobiology Laboratory, Tehran, Iran.

Background: PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) techniques have been used for the diagnosis of bacteria in some infections. In this study, we aimed to evaluate the diagnostic accuracy of PCR for the diagnosis of prosthetic joint infections (PJI) and to identify isolated microorganisms, using the RFLP method.

Methods: During January 2015 to January 2018, patients who were suspected of having PJI after arthroplasty surgery or were candidates for revision surgery due to loosening of implant entered the study. Read More

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http://dx.doi.org/10.1016/j.arth.2018.10.017DOI Listing
February 2019
3 Reads

Rotavirus-mediated alteration of gut microbiota and its correlation with physiological characteristics in neonatal calves.

J Microbiol 2019 Feb 19;57(2):113-121. Epub 2018 Nov 19.

Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University, Iksan, 54596, Republic of Korea.

Diarrhea is a fatal disease to neonatal calves, and rotavirus is the main pathogen associated with neonatal calf diarrhea. Although previous studies have reported that the gut microbiota is changed in calves during diarrhea, less is known about whether rotavirus infection alters the structure of the gut microbiota. Here, we characterized fecal microbial communities and identified possible relationships between the gut microbiota profiles and physiological parameters. Read More

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http://link.springer.com/10.1007/s12275-019-8549-1
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http://dx.doi.org/10.1007/s12275-019-8549-1DOI Listing
February 2019
14 Reads