15,947 results match your criteria Bacteroides Infection


In vitro digestion under simulated saliva, gastric and small intestinal conditions and fermentation by human gut microbiota of polysaccharides from the fruits of Lycium barbarum.

Int J Biol Macromol 2018 Dec 12. Epub 2018 Dec 12.

National Wolfberry Engineering Research Center, Yinchuan 750002, People's Republic of China. Electronic address:

In the present study, the digestion under simulated saliva, gastric and small intestinal conditions and in vitro fermentation by human gut microbiota of Lycium barbarum polysaccharides (LBPS) were investigated. As a result, LBPS contained carbohydrates, uronic acids, protein and polyphenols of 60.96 ± 5. Read More

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December 2018
1 Read

The composition and structure of the intestinal microflora of Anguilla marmorata at different growth rates: a deep sequencing study.

J Appl Microbiol 2018 Dec 15. Epub 2018 Dec 15.

Jimei University, Xiamen, 361021, China.

Aims: The aim of this study was to determine the intestinal microflora of Anguilla marmorata at different growth rates and to identify potential probiotic/pernicious bacteria.

Methods And Results: Bacterial communities from 8 different fish intestinal sites (including the intestinal contents and the intestinal mucosa) from three fish groups (3 fast-, 2 medium-, and 3 stunted-growth samples), 2 water samples, and 1 diet sample were characterized by Illumina next-generation sequencing. The data revealed that the predominant genera (relative abundance of bacteria genera >1%) in the intestine of fast- and medium-growth groups were Cetobacterium, Edwardsiella, Clostridium, Lactococcus, Bacteroides, Plesiomonas, and Akkermansia. Read More

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December 2018

Comparative analysis of the intestinal bacterial community and expression of gut immunity genes in the Chinese Mitten Crab (Eriocheir sinensis).

AMB Express 2018 Dec 13;8(1):192. Epub 2018 Dec 13.

Liaoning Provincial Key Laboratory of Zoonosis, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, 110866, People's Republic of China.

Remarkably little information is available about the interaction between the gut microbiota and intestinal immunity in fish and crustaceans. In our study, we used Illumina MiSeq sequencing and real-time quantitative PCR to compare the microbial community and immunity genes expression in the foregut, midgut and hindgut of Chinese mitten crab (Eriocheir sinensis). Our results indicated that the community richness of the midgut is higher than in the foregut or the hindgut, although the bacterial diversity in the hindgut is higher. Read More

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December 2018
1 Read

Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury.

J Transl Med 2018 Dec 13;16(1):353. Epub 2018 Dec 13.

School of Rehabilitation Medicine, Capital Medical University, No. 10 Jiaomen North Road, Fengtai District, Beijing, 100068, China.

Background: Neurogenic bowel dysfunction (NBD) is a major physical and psychological problem in patients with spinal cord injury (SCI), and gut dysbiosis is commonly occurs in SCI. Here, we document neurogenic bowel management of male patients with chronic traumatic complete SCI in our centre and perform comparative analysis of the gut microbiota between our patients and healthy males.

Methods: A total of 43 male patients with chronic traumatic complete SCI (20 with quadriplegia and 23 with paraplegia) and 23 healthy male adults were enrolled. Read More

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December 2018
2 Reads

The Dietary Intervention of Transgenic Low-Gliadin Wheat Bread in Patients with Non-Celiac Gluten Sensitivity (NCGS) Showed No Differences with Gluten Free Diet (GFD) but Provides Better Gut Microbiota Profile.

Nutrients 2018 Dec 12;10(12). Epub 2018 Dec 12.

Departamento de Mejora Genética Vegetal, Instituto de Agricultura Sostenible (IAS-CSIC), 14004 Córdoba, Spain.

The study evaluated the symptoms, acceptance, and digestibility of bread made from transgenic low-gliadin wheat, in comparison with gluten free bread, in Non-coeliac gluten sensitivity (NCGS) patients, considering clinical/sensory parameters and gut microbiota composition. This study was performed in two phases of seven days each, comprising a basal phase with gluten free bread and an E82 phase with low-gliadin bread. Gastrointestinal clinical symptoms were evaluated using the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire, and stool samples were collected for gluten immunogenic peptides (GIP) determination and the extraction of gut microbial DNA. Read More

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December 2018

Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis.

Mucosal Immunol 2018 Dec 12. Epub 2018 Dec 12.

Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Age-of-diagnosis associated variation in disease location and antimicrobial sero-reactivity has suggested fundamental differences in pediatric Crohn Disease (CD) pathogenesis. This variation may be related to pubertal peak incidence of ileal involvement and Peyer's patches maturation, represented by IFNγ-expressing Th1 cells. However, direct mucosal evidence is lacking. Read More

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December 2018

A decrease in anaerobic bacteria promotes overgrowth while β-glucan treatment restores the gut microbiota and attenuates colitis.

Gut Pathog 2018 3;10:50. Epub 2018 Dec 3.

1U995/Team2, INSERM, 59000 Lille, France.

Background: The intestinal microbiota plays a crucial role in the maintenance of gut homeostasis. Changes in crosstalk between the intestinal epithelial cells, immune cells and the microbiota are critically involved in the development of inflammatory bowel disease. In the experimental mouse model, the development of colitis induced by dextran sulfate sodium (DSS) promotes overgrowth of the opportunistic yeast pathogen . Read More

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December 2018
1 Read

Spatial impacts of a multi-individual grave on microbial and microfaunal communities and soil biogeochemistry.

PLoS One 2018 12;13(12):e0208845. Epub 2018 Dec 12.

Department of Biosystems Engineering and Soil Science, University of Tennessee, Knoxville, Tennessee, United States of America.

Decomposing vertebrates, including humans, result in pronounced changes in surrounding soil biogeochemistry, particularly nitrogen (N) and carbon (C) availability, and alter soil micro- and macrofauna. However, the impacts of subsurface human decomposition, where oxygen becomes limited and microbial biomass is generally lower, are far less understood. The goals of this study were to evaluate the impact of human decomposition in a multi-individual, shallow (~70 cm depth) grave on soil biogeochemistry and soil microbial and nematode communities. Read More

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December 2018

Selection of fast and slow growing bacteria from fecal microbiota using continuous culture with changing dilution rate.

Microb Ecol Health Dis 2018 30;29(1):1549922. Epub 2018 Nov 30.

Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.

: Nutrient and energy metabolism in human colon depends on bacterial growth rate that is determined by the colonic transit rate. : A novel approach, De-stat culture was used to distinguish the fast and slow growing sub-populations from fecal microbiota. : The enrichment and metabolism of bacteria from pooled fecal cultures of children was studied at dilution rates  = 0. Read More

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November 2018

GABA-modulating bacteria of the human gut microbiota.

Nat Microbiol 2018 Dec 10. Epub 2018 Dec 10.

Antimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.

The gut microbiota affects many important host functions, including the immune response and the nervous system. However, while substantial progress has been made in growing diverse microorganisms of the microbiota, 23-65% of species residing in the human gut remain uncultured, which is an obstacle for understanding their biological roles. A likely reason for this unculturability is the absence in artificial media of key growth factors that are provided by neighbouring bacteria in situ. Read More

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December 2018

Specific Bacteria and Metabolites Associated with Response to Fecal Microbiota Transplantation in Patients with Ulcerative Colitis.

Gastroenterology 2018 Dec 6. Epub 2018 Dec 6.

University of New South Wales, Sydney, Australia. Electronic address:

Background & Aims: Fecal microbiota transplantation (FMT) can induce remission in patients with ulcerative colitis (UC). In a randomized, controlled trial of FMT in patients with active UC, we aimed to identify bacterial taxonomic and functional factors associated with response to therapy.

Methods: We performed a double-blind trial of 81 patients with active UC randomly assigned to groups that received an initial colonoscopic infusion and then intensive multi-donor FMT or placebo enemas, 5 days/week for 8 weeks. Read More

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December 2018

Occurrence of microbial indicators, pathogenic bacteria and viruses in tropical surface waters subject to contrasting land use.

Water Res 2018 Nov 26;150:200-215. Epub 2018 Nov 26.

Department of Civil and Environmental Engineering, National University of Singapore, Singapore; NUS Environmental Research Institute, National University of Singapore, Singapore. Electronic address:

Fecal indicator bacteria, such as Escherichia coli (E.coli) and Enterococcus, have been widely used to indicate the presence of pathogens. However, the suitability of fecal indicator bacteria to represent health risks is still being challenged, particularly in tropical aquatic environments. Read More

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November 2018

The efficacy and safety of tazobactam/ceftolozane in combination with metronidazole in Japanese patients with complicated intra-abdominal infections.

J Infect Chemother 2018 Dec 5. Epub 2018 Dec 5.

Japan Development, MSD K.K., Tokyo, Japan. Electronic address:

Tazobactam/ceftolozane, a novel antimicrobial therapy, is active against Pseudomonas aeruginosa and most extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. We report the results of the efficacy and safety of tazobactam/ceftolozane in Japanese patients with complicated intra-abdominal infections (cIAI). A multicenter, open-label, noncomparative study (MK-7625A Protocol 013, ClinicalTrials. Read More

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December 2018

Microbial Intervention as a Novel Target in Treatment of Non-Alcoholic Fatty Liver Disease Progression.

Cell Physiol Biochem 2018 6;51(5):2123-2135. Epub 2018 Dec 6.

Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou,

Background/aims: Emerging evidence suggests a close link between gut microbiota and non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the association between gut microbiota and the DNA methylation of adiponectin (an adipocyte-specific adipocytokine) in rats, following diet-induced NAFLD.

Methods: 50 male SD rats were randomly divided into five groups with or without a high fat diet (HFD), antibiotics, and probiotics, in order to establish an imbalanced gut microbiota and probiotic treatment model in NAFLD rats. Read More

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December 2018
4 Reads

Airborne bacteria in a wastewater treatment plant: Emission characterization, source analysis and health risk assessment.

Water Res 2018 Nov 14;149:596-606. Epub 2018 Nov 14.

State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; National Engineering Laboratory for VOCs Pollution Control Material & Technology, University of Chinese Academy of Sciences, Beijing, 101408, China. Electronic address:

Wastewater treatment plants (WWTPs) are major sources of airborne bacteria, which could pose health risks to WWTP workers and surrounding residents. In this study, air samples were collected from various treatment facilities of a typical WWTP. Community compositions of airborne bacteria were identified by high-throughput sequencing technique. Read More

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November 2018
5 Reads

In vitro fermentation of O‑acetyl‑arabinoxylan from bamboo shavings by human colonic microbiota.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Institute of Agricultural Engineering, Fujian Academy of Agricultural Sciences, Fuzhou 350003, PR China.

BSH-1 is an O‑acetyl-arabinoxylan obtained from bamboo shavings. This study investigated its fermentation behavior by human colonic bacteria in vitro. Results showed that BSH-1 remarkably modulated the composition of colonic microbiota, mainly by increasing the growth of potential beneficial genera (i. Read More

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December 2018
8 Reads

Induction Effects of Bacteroides fragilis Derived Outer Membrane Vesicles on Toll Like Receptor 2, Toll Like Receptor 4 Genes Expression and Cytokines Concentration in Human Intestinal Epithelial Cells.

Cell J 2019 Apr 18;21(1):57-61. Epub 2018 Nov 18.

Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.

Objective: Gastrointestinal (GI) tract, like other mucosal surface, is colonized with a microbial population known as gut microbiota. Outer membrane vesicles (OMVs) which are produced by gram negative bacteria could be sensed by Toll like receptors (TLRs). The interaction between gut microbiota and TLRs affects homeostasis and immune responses. Read More

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April 2019
3 Reads

Complete genome sequence of SM1504, a cytophagaceae bacterium isolated from Arctic surface seawater.

Stand Genomic Sci 2018 26;13:33. Epub 2018 Nov 26.

1State Key Laboratory of Microbial Technology, Marine Biotechnology Research Center, Shandong University, No.72, Binhai Rd, Qingdao, 266237 China.

SM1504 was isolated from Arctic surface seawater and classified as a novel genus of the phylum . To date, no genomes have been reported, their genomic compositions and metabolic features are still unknown. Here, we reported the complete genome sequence of SM1504, which comprises 5,379,839 bp with an average GC content of 37. Read More

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November 2018
1 Read

Cobalamin (Vitamin B12) Induced a Shift in Microbial Composition and Metabolic Activity in an Colon Simulation.

Front Microbiol 2018 16;9:2780. Epub 2018 Nov 16.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China.

Cobalamin deficiency is believed to be related to disturbances in cell division, neuropathy, nervous system disease and pernicious anemia. Elderly people are usually advised to supplement their diets with cobalamin. As cobalamin has several forms, the effects of different forms of cobalamin on gut microbiota were investigated in this study. Read More

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November 2018
1 Read

Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling.

Exp Mol Med 2018 Nov 30;50(12):155. Epub 2018 Nov 30.

Department of Pediatric Surgery, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

The link between antibiotic treatment and IF-associated liver disease (IFALD) is unclear. Here, we study the effect of antibiotic treatment on bile acid (BA) metabolism and investigate the involved mechanisms. The results showed that pediatric IF patients with cholestasis had a significantly lower abundance of BA-biotransforming bacteria than patients without cholestasis. Read More

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November 2018
1 Read

Effects of Panax ginseng polysaccharides on the gut microbiota in mice with antibiotic-associated diarrhea.

Int J Biol Macromol 2018 Nov 30;124:931-937. Epub 2018 Nov 30.

Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, PR China; College of Chinese Medicinal Material, Jilin Agricultural University, Changchun 130118, PR China. Electronic address:

Panax ginseng is a traditional medicinal plant used in most Asian countries to cure many diseases. The benefits of ginseng are due to its primary active component, polysaccharides. Gut microbiota dysbiosis is a worldwide problem associating with antibiotic use. Read More

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November 2018
1 Read

A Gut Feeling for Metformin.

Cell Metab 2018 Dec;28(6):808-810

Toronto General Hospital Research Institute, UHN, Toronto, ON M5G 1L7, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada; Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada. Electronic address:

Metformin is a first-line glucose-lowering agent in patients with type 2 diabetes (T2D). Recently in Nature Medicine, Sun et al. (2018) reported that short-term metformin therapy decreases gut Bacteroides fragilis, consequently increasing glycoursodexoycholic acid (GUDCA) levels in humans. Read More

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December 2018
4 Reads

Comparative genomics of transport proteins in seven Bacteroides species.

PLoS One 2018 5;13(12):e0208151. Epub 2018 Dec 5.

Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA, United States of America.

The communities of beneficial bacteria that live in our intestines, the gut microbiome, are important for the development and function of the immune system. Bacteroides species make up a significant fraction of the human gut microbiome, and can be probiotic and pathogenic, depending upon various genetic and environmental factors. These can cause disease conditions such as intra-abdominal sepsis, appendicitis, bacteremia, endocarditis, pericarditis, skin infections, brain abscesses and meningitis. Read More

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December 2018
3 Reads

Characterization of Polysaccharides from Feijoa Fruits ( Acca sellowiana Berg.) and Their Utilization as Growth Substrates by Gut Commensal Bacteroides Species.

J Agric Food Chem 2018 Dec 5. Epub 2018 Dec 5.

Ferrier Research Institute , Victoria University of Wellington , 69 Gracefield Road , Lower Hutt 5040 , New Zealand.

Polysaccharides from feijoa fruit were extracted and analyzed; the composition of these polysaccharides conforms to those typically found in the primary cell walls of eudicotyledons. The two major polysaccharide extracts consisted of mainly pectic polysaccharides and hemicellulosic polysaccharides [xyloglucan (77%) and arabinoxylan (16%)]. A collection of commensal Bacteroides species was screened for growth in culture using these polysaccharide preparations and placed into five categories based on their preference for each substrate. Read More

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December 2018
2 Reads

Microbiota and Pathogen Proteases Modulate Type III Secretion Activity in Enterohemorrhagic Escherichia coli.

MBio 2018 Dec 4;9(6). Epub 2018 Dec 4.

Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

Enteric pathogens have complex interactions with the gut microbiota. Most of what is known about them has focused on microbiota-derived metabolites or small molecules that serve as nutrients and/or signals to aid in growth or transcriptionally regulate virulence gene expression. A common virulence strategy is to express a type III secretion system (T3SS), which is a molecular syringe deployed by many Gram-negative pathogens to hijack host cell function. Read More

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December 2018
1 Read

Modulation of intestinal microbiota, morphology and mucin composition by dietary insect meal inclusion in free-range chickens.

BMC Vet Res 2018 Dec 4;14(1):383. Epub 2018 Dec 4.

Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095, Grugliasco, TO, Italy.

Background: Gut health in poultry depends on the balance between the host, intestinal microbiota, intestinal microscopic features and diet. The effects of insect meal (a promising alternative protein source for poultry feed) on chicken gut morphology have recently been reported, but no data about intestinal microbiota and mucin composition modulation are available. The present study evaluated the effects of dietary Tenebrio molitor (TM) meal inclusion on gut health of free-range chickens by intestinal microbiota, morphology and mucin composition characterization. Read More

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December 2018
6 Reads

Food waste fermentation in a leach bed reactor: Reactor performance, and microbial ecology and dynamics.

Bioresour Technol 2018 Nov 19;274:153-161. Epub 2018 Nov 19.

Department of Civil and Environmental Engineering, University of Waterloo, 200 University Avenue West, Ontario N2L3G1, Canada. Electronic address:

Food waste fermentation was investigated in a leach bed reactor operated at acidic, neutral and alkaline conditions. Highest solids reduction of 87% was obtained at pH 7 in 14 days of reaction time with minimum mixing. The concentration of volatile fatty acids increased to 28. Read More

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November 2018
1 Read

Comparative decay of sewage-associated marker genes in beach water and sediment in a subtropical region.

Water Res 2018 Nov 2;149:511-521. Epub 2018 Nov 2.

CSIRO Land and Water, Lucas Heights, NSW, 2234, Australia.

There is a growing move towards using the quantitative polymerase chain (qPCR)-based sewage-associated marker genes to assess surface water quality. However, a lack of understanding about the persistence of many sewage-associated markers creates uncertainty for those tasked with investigating microbial water quality. In this study, we investigated the decay of two qPCR FIB [E. Read More

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November 2018
1 Read

Effects of dietary supplementation of alfalfa meal on growth performance, carcass characteristics, meat and egg quality, and intestinal microbiota in Beijing-you chicken.

Poult Sci 2018 Nov 29. Epub 2018 Nov 29.

Beijing Research and Development Center for Grass and Environment, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.

This study was conducted to investigate the effects of alfalfa meal supplementation on growth performance, carcass characteristics, meat and egg quality, and intestinal microbiota in chickens. A total of 600 healthy 20-wk female Beijing-you chickens (a local Chinese chicken breed) were selected and randomly assigned into 4 dietary treatments: 0, 5, 8, and 10% alfalfa meal supplementation. Chickens were raised in a free-range system for 56 d. Read More

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November 2018
2 Reads

Effects of proton pump inhibitor on the human gut microbiome profile in multi-ethnic groups in Singapore.

Singapore Med J 2018 Nov 29. Epub 2018 Nov 29.

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

Introduction: The objectives of this study were to examine the effects of ethnicity, gender, and a proton pump inhibitor (PPI), omeprazole, on the human gut microbiome. PPIs are commonly used for the treatment of acid-related disorders. We hypothesised that PPI therapy might perturb microbial communities and alter the gut microbiome. Read More

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November 2018
2 Reads

Alterations of Gut Microbiota in Cholestatic Infants and Their Correlation With Hepatic Function.

Front Microbiol 2018 13;9:2682. Epub 2018 Nov 13.

Department of Pediatrics, The Third Hospital of Hebei Medical University, Shijiazhuang, China.

Cholestasis is a major hepatic disease in infants, with increasing morbidity in recent years. Accumulating evidence has revealed that the gut microbiota (GM) is associated with liver diseases, such as non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. However, GM alterations in cholestatic infants and the correlation between the GM and hepatic functions remain uninvestigated. Read More

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November 2018
1 Read

Genomic Islands Confer Heavy Metal Resistance in and Isolated from a Gold/Copper Mine.

Genes (Basel) 2018 Nov 23;9(12). Epub 2018 Nov 23.

Institute of Environmental Microbiology, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Heavy metals (HMs) are compounds that can be hazardous and impair growth of living organisms. Bacteria have evolved the capability not only to cope with heavy metals but also to detoxify polluted environments. Three heavy metal-resistant strains of and one of were isolated from the gold/copper Zijin mining site, Longyan, Fujian, China. Read More

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November 2018
2 Reads

Probiotics in Celiac Disease.

Nutrients 2018 Nov 23;10(12). Epub 2018 Nov 23.

Department of Paediatrics, Paediatric Hospital Giovanni XXIII, Via Amendola 207, 70126 Bari, Italy.

Recently, the interest in the human microbiome and its interplay with the host has exploded and provided new insights on its role in conferring host protection and regulating host physiology, including the correct development of immunity. However, in the presence of microbial imbalance and particular genetic settings, the microbiome may contribute to the dysfunction of host metabolism and physiology, leading to pathogenesis and/or the progression of several diseases. Celiac disease (CD) is a chronic autoimmune enteropathy triggered by dietary gluten exposure in genetically predisposed individuals. Read More

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November 2018
3 Reads

Polymerase Chain Reaction Assay Using the Restriction Fragment Length Polymorphism Technique in the Detection of Prosthetic Joint Infections: A Multi-Centered Study.

J Arthroplasty 2018 Oct 25. Epub 2018 Oct 25.

Department of Molecular Pathology, National Research Institute of Tuberculosis and Lung Diseases, Shahid Behshti University of Medical Sciences, Tehran, Iran; Department of Molecular Biology, Dr. Khosroshahi's Pathobiology Laboratory, Tehran, Iran.

Background: PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) techniques have been used for the diagnosis of bacteria in some infections. In this study, we aimed to evaluate the diagnostic accuracy of PCR for the diagnosis of prosthetic joint infections (PJI) and to identify isolated microorganisms, using the RFLP method.

Methods: During January 2015 to January 2018, patients who were suspected of having PJI after arthroplasty surgery or were candidates for revision surgery due to loosening of implant entered the study. Read More

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October 2018
2 Reads

Deciphering the Human Gut Microbiome of Urolithin Metabotypes: Association with Enterotypes and Potential Cardiometabolic Health Implications.

Mol Nutr Food Res 2018 Nov 24:e1800958. Epub 2018 Nov 24.

Laboratory of Food & Health Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, 30100, Murcia, Spain.

Scope: The gut microbiota ellagitannin-metabolizing phenotypes (i.e., urolithin metabotypes [UMs]) are proposed as potential cardiovascular disease (CVD) risk biomarkers because the host blood lipid profile is reported to be associated with specific UMs. Read More

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November 2018
1 Read

Fucosylated chondroitin sulfate from Isostichopus badionotus alleviates metabolic syndromes and gut microbiota dysbiosis induced by high-fat and high-fructose diet.

Int J Biol Macromol 2018 Nov 19;124:377-388. Epub 2018 Nov 19.

College of Biosystem Engineering and Food Science, Zhejiang University, Hangzhou 310058, China. Electronic address:

Fucosylated chondroitin sulfate from Isostichopus badionotus (fCS-Ib) is a kind of sulfated polysaccharides with well-repeated structure. In our former publications, fCS-Ib has been reported to be a functional food ingredient with hypoglycemic and antilipemic activities. However, there is no systematic study to investigate the effects of fCS-Ib on metabolic syndromes. Read More

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November 2018
9 Reads

Pilot Safety Evaluation of a Novel Strain of .

Front Genet 2018 6;9:539. Epub 2018 Nov 6.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.

ELH-B2 is considered as a potential next-generation probiotic due to its preventive effects on lipopolysaccharides-associated inflammation and intestinal microbiota disorders in mice. To study safety issues associated with ELH-B2, we conducted comprehensive and systematic experiments, including genetic assessments of potential virulence and antimicrobial resistance genes, and an acute toxicity study of both immunocompetent and immunosuppressed mice via cyclophosphamide treatment. The results indicated that this novel strain is non-toxigenic, fragilysin is not expressed, and most of potential virulence genes are correlated with cellular structures such as capsular polysaccharide and polysaccharide utilizations. Read More

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November 2018
3 Reads

Insights Into the Bovine Milk Microbiota in Dairy Farms With Different Incidence Rates of Subclinical Mastitis.

Front Microbiol 2018 16;9:2379. Epub 2018 Oct 16.

Key Laboratory of Control Technology and Standard for Agro-product Safety and Quality, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, China.

Bovine mastitis continues to be a complex disease associated with significant economic loss in dairy industries worldwide. The incidence rate of subclinical mastitis (IRSCM) can show substantial variation among different farms; however, the milk microbiota, which have a direct influence on bovine mammary gland health, have never been associated with the IRSCM. Here, we aimed to use high-throughput DNA sequencing to describe the milk microbiota from two dairy farms with different IRSCMs and to identify the predominant mastitis pathogens along with commensal or potential beneficial bacteria. Read More

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October 2018
1 Read

Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women.

Sci Rep 2018 Nov 20;8(1):17135. Epub 2018 Nov 20.

Division of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, IL, USA.

We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI < 25 kg/m) and 50% obese (BMI ≥ 30 kg/m)] to examine the ecological co-occurrence network topology of the gut microbiota as well as the relationship of short chain fatty acids (SCFAs) with obesity. Ghanaians consumed significantly more dietary fiber, had greater microbial alpha-diversity, different beta-diversity, and had a greater concentration of total fecal SCFAs (p-value < 0.002). Read More

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November 2018
3 Reads

Pharmacokinetics and pharmacodynamics of oral pradofloxacin administration in dogs.

Am J Vet Res 2018 Dec;79(12):1268-1276

OBJECTIVE To determine whether target values for pharmacokinetic-pharmacodynamic (PK-PD) indices against selected canine pathogens were achievable for pradofloxacin in various canine fluids and leukocytes. ANIMALS 8 healthy adult hounds (experiments 1 and 2) and 6 healthy adult dogs (experiment 3). PROCEDURES In 3 experiments, pradofloxacin (3, 6, or 12 mg/kg) and enrofloxacin (5 or 10 mg/kg) were orally administered once a day for 5 days, and blood, interstitial fluid (ISF), and other fluid samples were collected at various points. Read More

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December 2018
6 Reads

Rotavirus-mediated alteration of gut microbiota and its correlation with physiological characteristics in neonatal calves.

J Microbiol 2018 Nov 19. Epub 2018 Nov 19.

Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University, Iksan, 54596, Republic of Korea.

Diarrhea is a fatal disease to neonatal calves, and rotavirus is the main pathogen associated with neonatal calf diarrhea. Although previous studies have reported that the gut microbiota is changed in calves during diarrhea, less is known about whether rotavirus infection alters the structure of the gut microbiota. Here, we characterized fecal microbial communities and identified possible relationships between the gut microbiota profiles and physiological parameters. Read More

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November 2018
6 Reads

Omadacycline gut microbiome exposure does not induce proliferation or toxin production in a model that simulates the proximal, medial and distal human colon.

Antimicrob Agents Chemother 2018 Nov 19. Epub 2018 Nov 19.

Leeds Institute of Biomedical and Clinical Sciences, Faculty of Medicine and Health, University of Leeds, Leeds, UK

A clinically reflective model of the human colon was used to investigate the effects of the broad-spectrum antibiotic omadacycline on the gut microbiome, and subsequent potential to induce simulated infection (CDI). Triple stage chemostat gut models were inoculated with pooled human faecal slurry from healthy volunteers (age ≥60 years). Models were challenged twice with 107 cfu spores (PCR ribotype 027). Read More

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November 2018
1 Read

Effects of IRW and IQW on Oxidative Stress and Gut Microbiota in Dextran Sodium Sulfate-Induced Colitis.

Cell Physiol Biochem 2018 19;51(1):441-451. Epub 2018 Nov 19.

College of bioscience and biotechnology, Hunan Agricultural University, Changsha, China.

Background/aims: There are known links between inflammatory bowel disease (IBD) and changes in the microbiota of the gut and inflammation and oxidative stress. In this study, a colitis model induced by dextran sodium sulfate (DSS) in mice is used to evaluate whether the presence of bioactive peptides IRW (Ile-Arg-Trp) and IQW (Ile-Gln-Trp) peptides is advantageous.

Methods: The mice were arbitrarily assigned to the following four groups: (i) control (untreated), (ii) dextran sodium sulfate (DSS) treated, (iii) IRW-DSS treated, and (iv) IQW-DSS treated. Read More

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December 2018
5 Reads
2.875 Impact Factor

Gut Microbial Compositions in Four Age Groups of Tibetan Minipigs.

Pol J Microbiol 2018 ;67(3):383-388

Laboratory Animal Center, Southern Medical University, Guangzhou, China.

In this study, the gut microbiota was characterized in four age strata of Tibetan minipigs. Results indicated that the fecal bacteria of 7-, 28-, 56-, and 180-day-old minipigs did not significantly differ in terms of phylogenetic diversity (i.e. Read More

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January 2018

Bacterial Microbiota and Fatty Acids in the Faeces of Overweight and Obese Children.

Pol J Microbiol 2018 ;67(3):339-345

Institute of Chemistry, Environmental Protection and Biotechnology, Jan Długosz University in Częstochowa, Częstochowa, Poland.

The growing number of children with overweight and obesity constitutes a major health problem of the modern world and it has been suggested that intestinal microbiota may influence energy intake from food. The objectives of this study were to determine quantity and proportions of dominant genera of Bacteroides, Prevotella (phylum Bacteroidetes ); Clostridium , Lactobacillus (phylum Firmicutes ) and Bifidobacterium (phylum Actinobacteria ) in the intestines and to determine the content of short-chain fatty acids (SCFAs) and branched-chain fatty acids (BCFAs) in the stool of 20 obese children and 20 children with normal body weight. Strains classified as Firmicutes ( Clostridium and Lactobacillus ) predominated in stool microbiota of obese children, while those of Bacteroidetes ( Prevotella and Bacteroides ) were in minority ( p < 0. Read More

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January 2018
4 Reads

Arabinoxylan from Argentinian whole wheat flour promote the growth of Lactobacillus reuteri and Bifidobacterium breve.

Lett Appl Microbiol 2018 Nov 16. Epub 2018 Nov 16.

Institute of Food Science and Technology of Córdoba, ICYTAC-CONICET-UNC, Córdoba, Argentina.

Arabinoxylans are part of dietary fiber and have received attention given their emergent prebiotic character. Four arabinoxylans extracts were obtained from Argentinian soft and hard wheat. In vitro assays were performed to describe the extent to which the extracts from whole wheat flour support selective growth of Bifidobacterium breve and probiotic Lactobacillus reuteri ATCC23272 in a defined media. Read More

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November 2018
2 Reads

Selective colonization ability of human fecal microbes in different mouse gut environments.

ISME J 2018 Nov 15. Epub 2018 Nov 15.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

Mammalian hosts constantly interact with diverse exogenous microbes, but only a subset of the microbes manage to colonize due to selective colonization resistance exerted by host genetic factors as well as the native microbiota of the host. An important question in microbial ecology and medical science is if such colonization resistance can discriminate closely related microbial species, or even closely related strains of the same species. Using human-mouse fecal microbiota transplantation and metagenomic shotgun sequencing, we reconstructed colonization patterns of human fecal microbes in mice with different genotypes (C57BL6/J vs. Read More

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November 2018
14 Reads

Applying simple linear combination, multiple logistic and factor analysis methods for candidate fecal bacteria as novel biomarkers for early detection of adenomatous polyps and colon cancer.

J Microbiol Methods 2018 Dec 12;155:82-88. Epub 2018 Nov 12.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Colorectal cancer (CRC) is the third leading cause of cancer, and presents a considerable disease burden, worldwide. Recently, the gut microbiota has been proposed as a potential risk factor for CRC, and even adenomatous polyps (AP). Here, the aim of this study was to investigate the role of selected gut bacteria as fecal bacterial biomarkers, in early detection of CRC and AP. Read More

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December 2018
4 Reads

Specific Members of the Gut Microbiota are Reliable Biomarkers of Irradiation Intensity and Lethality in Large Animal Models of Human Health.

Radiat Res 2018 Nov 15. Epub 2018 Nov 15.

b   Department of Surgery, University of Illinois at Chicago, Chicago, Illinois.

The development of effective biomarkers for detecting the magnitude of radiation exposure and resiliency of host response is crucial to identifying appropriate treatment strategies after radiation exposure. We hypothesized that the gastrointestinal resident bacteria would demonstrate predictable, dose-dependent changes after radiation exposure across two large animal models of acute radiation syndrome. Here, Göttingen minipigs (GMP) (n = 50) and rhesus macaques (n = 48) were exposed to five dose levels (resulting in mortality rates of 33-100% and 25-68. Read More

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November 2018
3 Reads

Antimicrobial Susceptibility Patterns of Anaerobic Bacterial Clinical Isolates From 2014 to 2016, Including Recently Named or Renamed Species.

Ann Lab Med 2019 Mar;39(2):190-199

Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea.

Background: Anaerobic bacterial resistance trends may vary across regions or institutions. Regional susceptibility patterns are pivotal in the empirical treatment of anaerobic infections. We determined the antimicrobial resistance patterns of clinically important anaerobic bacteria, including recently named or renamed anaerobes. Read More

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March 2019
1 Read