5,254 results match your criteria Bacterial Vaginosis

Human Trial for the Effect of Plasma-Activated Water Spray on Vaginal Cleaning in Patients with Bacterial Vaginosis.

Med Sci (Basel) 2022 Jun 18;10(2). Epub 2022 Jun 18.

Department of Pharmacology, College of Medicine, Hanyang University, Seoul 04736, Korea.

Underwater plasma discharge temporally produces several reactive radicals and/or free chlorine molecules in water, which is responsible for antimicrobial activity. Hence, it can simply sanitize tap water without disinfectant treatment. Additionally, the spraying technique using cleaning water exploits deep application in the narrow and curved vaginal tract of patients. Read More

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Screening for low-tract genital infections in women with threatened preterm labour. Which role?

Gynecol Obstet Invest 2022 Jun 22. Epub 2022 Jun 22.

Objectives: to evaluate the possible relationship between cultural specimens and preterm birth in women admitted for threatened preterm labour. Preterm birth is the leading cause of neonatal mortality and antenatal hospitalization: several risk factors including intrauterine infections have been identified but its real causes remain poorly understood.

Design: retrospective, multicentre, cohort study including 250 women admitted for threatened preterm labour. Read More

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Is there any association between adherence to the Mediterranean Diet and Dietary Total Antioxidant Capacity with Bacterial Vaginosis? Results from a Case-Control study.

BMC Womens Health 2022 Jun 20;22(1):244. Epub 2022 Jun 20.

Department of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Bacterial vaginosis, BV, is a common inflammatory vaginal dysbiosis. The Mediterranean diet, MD, containing foods rich in antioxidant compounds, is shown to be beneficial for inflammatory conditions. This study aimed to investigate the association between MD adherence and dietary total antioxidant capacity (DTAC) with BV. Read More

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Preconception reproductive tract infections status and adverse pregnancy outcomes: a population-based retrospective cohort study.

BMC Pregnancy Childbirth 2022 Jun 20;22(1):501. Epub 2022 Jun 20.

NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, 400020, Shanghai, China.

Background: Reproductive tract infections can cause serious adverse outcomes for pregnant women such as spontaneous abortion and preterm birth. However, it is unclear whether maternal reproductive tract infection before pregnancy would also be related to any adverse pregnancy outcomes. This study aims to investigate the association of maternal preconception reproductive tract infections with subsequent adverse pregnancy outcomes. Read More

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Clue Cells and Pseudo Clue Cells in Different Morphotypes of Bacterial Vaginosis.

Front Cell Infect Microbiol 2022 27;12:905739. Epub 2022 May 27.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia.

Introduction: Clue cells (epithelial cells heavily covered with adherent bacteria) are an accepted clue to the diagnosis of bacterial vaginosis. However, the exact morphologic criteria of clue cells and bacterial adherence were never elaborated.

Materials And Methods: We investigated adhesive and cohesive patterns of main microbiota groups in vaginal discharge using fluorescence hybridization (FISH). Read More

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The vaginal microbiome: A complex milieu affecting risk of human papillomavirus persistence and cervical cancer.

Curr Probl Cancer 2022 Jun 9;46(4):100877. Epub 2022 Jun 9.

Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.

The purpose of this review is to describe the existing literature regarding the relationship between the vaginal microbiome, human papillomavirus persistence, and cervical cancer risk, as well as to discuss factors that mediate these relationships. Data suggest that alterations in the vaginal microbiome affect the risk of human papillomavirus infection and persistence, which has downstream effects on cervical dysplasia and cancer risk. The homeostatic Lactobillus species L. Read More

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Gardnerella vaginalis clades in pregnancy: New insights into the interactions with the vaginal microbiome.

PLoS One 2022 14;17(6):e0269590. Epub 2022 Jun 14.

Microbiology, DIMES, University of Bologna, Bologna, Italy.

Gardnerella vaginalis (GV) is an anaerobic bacterial species involved in the pathogenesis of bacterial vaginosis (BV), a condition of vaginal dysbiosis associated with adverse pregnancy outcomes. GV strains are categorized into four clades, characterized by a different ability to produce virulence factors, such as sialidase. We investigated the distribution of GV clades and sialidase genes in the vaginal ecosystem of a cohort of pregnant women, assessing the correlations between GV clades and the whole vaginal microbiome. Read More

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Probiotics are a good choice for the treatment of bacterial vaginosis: a meta-analysis of randomized controlled trial.

Reprod Health 2022 Jun 13;19(1):137. Epub 2022 Jun 13.

Department of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Background: Bacterial vaginosis (BV) is one of the most common vaginal infectious diseases in female reproductive period. Although the existing view is that probiotic treatment may be one of the feasible methods for the treatment of BV, different intervention methods lead to different treatment results. Therefore, up-to-date and comprehensive evidence in this regard is essential for the development of intervention strategies. Read More

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Models of Murine Vaginal Colonization by Anaerobically Grown Bacteria.

J Vis Exp 2022 05 25(183). Epub 2022 May 25.

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California; Glycobiology Research and Training Center, UCSD;

The mammalian vagina can be colonized by many bacterial taxa. The human vaginal microbiome is often dominated by Lactobacillus species, but one-in-four women experience bacterial vaginosis, in which a low level of lactobacilli is accompanied by an overgrowth of diverse anaerobic bacteria. This condition has been associated with many health complications, including risks to reproductive and sexual health. Read More

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Effect of estrogen on vaginal complications of pessary use: a systematic review and meta-analysis.

Climacteric 2022 Jun 13:1-10. Epub 2022 Jun 13.

Department of Obstetrics and Gynecology, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China.

Objective: We aimed to systematically review the impact of local estrogen use in combination with a pessary on vaginal complications in postmenopausal women with pelvic organ prolapse (POP).

Methods: We searched databases including Medline, Embase, PubMed, Clinical Trials and the Cochrane Central Register of Controlled Trials for relevant literature published in English from inception to 31 May 2021. Only randomized controlled trials (RCTs) and cohort studies were included. Read More

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The prevalence of gonococcal and non-gonococcal infections in women referred to obstetrics and gynecology clinics.

Infez Med 2022 1;30(2):247-253. Epub 2022 Jun 1.

Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

Bacterial vaginosis is a condition caused by changes in the vaginal microbial ecosystem and increases the risk of preterm delivery, premature rupture of membranes, endometritis, and weight loss of the baby. This study aimed to evaluate the frequency of gonococcal and non-gonococcal genital infections in women referred to clinics in Ilam, Iran. Two swab samples were taken from each patient using a sterile swab, one swab was placed in a THB medium for the culture of and the other in PBS buffer for PCR. Read More

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Vaginal colonization of women after oral administration of Lactobacillus crispatus strain NTCVAG04 from the human microbiota.

Minerva Obstet Gynecol 2022 Jun 8. Epub 2022 Jun 8.

Laboratory of Molecular Microbiology and Biotechnology (LAMMB), Department of Medical Biotechnologies, University of Siena, Siena, Italy.

Background: The genomic approach has deeply changed the microbiology perspective, mainly concerning the microbioma identification. In this regard, some microbes colonize the healthy vagina. Vaginitis is a common gynecological ailment and includes bacterial vaginosis (BV), usually caused by local dysbiosis, such as a microbiota imbalance. Read More

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Effects of Pro/Prebiotics Alone over Pro/Prebiotics Combined with Conventional Antibiotic Therapy to Treat Bacterial Vaginosis: A Systematic Review.

Int J Clin Pract 2022 21;2022:4774783. Epub 2022 Apr 21.

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Bacterial vaginosis (BV), caused by an imbalance in the vaginal microbiota, can be treated and prevented by probiotics. Pregnant women with BV can experience premature labor and spontaneous abortions. Probiotics and prebiotics promote the proliferation of beneficial microorganisms, alter the composition of the vaginal microbiota, and prevent intravaginal infections in postmenopausal women. Read More

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Single-Dose, Bioadhesive Clindamycin 2% Gel for Bacterial Vaginosis: A Randomized Controlled Trial.

Obstet Gynecol 2022 Jun 2;139(6):1092-1102. Epub 2022 May 2.

Daré Bioscience, Inc., San Diego, California; the University of Pittsburgh and Magee-Womens Research Institute, Pittsburgh, Pennsylvania; Gendreau Consulting, LLC, Poway, California; Health Decisions, Inc., Durham, North Carolina; Segal Trials and the University of Miami Miller School of Medicine, Miami, Florida; Precision Trials AZ, LLC, Phoenix, Arizona; Praetorian Pharmaceutical Research and West Jefferson Medical Center, Marrero, Louisiana; Southern Clinical Research Associates, LLC, Metairie, Louisiana; and TMC Life Research, Inc., Houston, Texas.

Objective: To assess efficacy and safety of a single-dose vaginal clindamycin gel for bacterial vaginosis treatment.

Methods: We conducted a double-blind, placebo-controlled, randomized study comparing clindamycin gel with placebo (2:1 ratio). Entry required clinical diagnosis of bacterial vaginosis, that is, all four Amsel's criteria, without other genital infections. Read More

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Phylogeny-guided microbiome OTU-specific association test (POST).

Microbiome 2022 Jun 7;10(1):86. Epub 2022 Jun 7.

Bioinformatics Research Center, North Carolina State University, Raleigh, 27606, USA.

Background: The relationship between host conditions and microbiome profiles, typically characterized by operational taxonomic units (OTUs), contains important information about the microbial role in human health. Traditional association testing frameworks are challenged by the high dimensionality and sparsity of typical microbiome profiles. Phylogenetic information is often incorporated to address these challenges with the assumption that evolutionarily similar taxa tend to behave similarly. Read More

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Efficacy of Linn. Pod's Sitz Bath plus Vaginal Pessary in Syndromic Management of Abnormal Vaginal Discharge: A Randomized Controlled Trial.

Evid Based Complement Alternat Med 2022 25;2022:5769555. Epub 2022 May 25.

Faculty of Business and Management Studies, Koforidua Technical University, Koforidua, Ghana.

Objectives: Abnormal vaginal discharge () is a common public health problem that significantly disrupts the health-related quality of life (HRQoL). Syndromic management infers the concurrent treatment of two or more infections. Hence, a comparative, single-blind study was planned to determine the efficacy of ( Linn. Read More

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Sustained effect of LACTIN-V (Lactobacillus crispatus CTV-05) on genital immunology following standard bacterial vaginosis treatment: results from a randomised, placebo-controlled trial.

Lancet Microbe 2022 Jun 21;3(6):e435-e442. Epub 2022 Apr 21.

Department of Medicine, University of Toronto, Toronto, ON, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada; Department of Medicine, University Health Network, Toronto, ON, Canada.

Background: Bacterial vaginosis might increase HIV risk by eliciting genital inflammation and epithelial barrier disruption, whereas vaginal Lactobacillus crispatus is associated with immune quiescence and HIV protection. We investigated the effect of a live biotherapeutic containing L crispatus CTV-05 (LACTIN-V) on genital immunology and key vaginal bacteria.

Methods: This substudy included women aged 18-45 years who participated in the randomised, placebo-controlled, phase 2b trial of LACTIN-V to reduce bacterial vaginosis recurrence, conducted at four universities and hospitals in the USA. Read More

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Altered Vaginal Microbiota Composition Correlates With Human Papillomavirus and Mucosal Immune Responses in Women With Symptomatic Cervical Ectopy.

Front Cell Infect Microbiol 2022 17;12:884272. Epub 2022 May 17.

Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, Mexico.

Cervical ectopy is a benign condition of the lower genital tract that is frequently detected in women of reproductive age. Although cervical ectopy is regarded as a physiological condition, some women experience symptoms such as leucorrhoea, persistent bleeding and recurrent vaginal infections that require medical intervention. Cervical ectopy has not been linked to cervical cancer, but it is thought to facilitate the acquisition of sexually transmitted diseases (STDs), like Human Papillomavirus (HPV) infection, as it provides a favorable microenvironment for virus infection and dissemination. Read More

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A Deep Look at the Vaginal Environment During Pregnancy and Puerperium.

Front Cell Infect Microbiol 2022 17;12:838405. Epub 2022 May 17.

Microbiology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

A deep comprehension of the vaginal ecosystem may hold promise for unraveling the pathophysiology of pregnancy and may provide novel biomarkers to identify subjects at risk of maternal-fetal complications. In this prospective study, we assessed the characteristics of the vaginal environment in a cohort of pregnant women throughout their different gestational ages and puerperium. Both the vaginal bacterial composition and the vaginal metabolic profiles were analyzed. Read More

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Molecular Identification of Cervical Microbes in HIV-Negative and HIV-Positive Women in an African Setting Using a Customized Bacterial Vaginosis Microbial DNA Quantitative PCR (qPCR) Array.

Microbiol Spectr 2022 Jun 1:e0222921. Epub 2022 Jun 1.

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Towngrid.7836.a, Cape Town, South Africa.

Bacterial vaginosis (BV) is a common polymicrobial vaginal disorder that is associated with sexually transmitted infections (STIs), including HIV. Several studies have utilized broad-range 16S rRNA gene PCR assays with sequence analysis to characterize cervicovaginal bacterial communities of women with healthy and diseased conditions. With the high burden of BV and STIs among African women, there is a need for targeted PCR assays that can rapidly determine the true epidemiological profile of key cervical microbes, including BV-associated bacteria, and a need to explore the utility of such assays for microbiological diagnosis of BV. Read More

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Accurate 16S Absolute Quantification Sequencing Revealed Vaginal Microecological Composition and Dynamics During Mixed Vaginitis Treatment With Fufang FuRong Effervescent Suppository.

Front Cell Infect Microbiol 2022 13;12:883798. Epub 2022 May 13.

Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Background: The diagnosis and treatment of mixed vaginitis are more complicated than single pathogenic infections, and there may be adverse reactions and several contraindications to conventional antibiotic therapy. Therefore, this study aimed to evaluate the preliminary effects of Fufang Furong Effervescent Suppository for the management of aerobic vaginitis (AV) mixed with bacterial vaginosis (BV) using Accurate 16S absolute quantification sequencing (Accu16S).

Methods: In the present randomized, blind, multi-center clinical trial, women (20 to 55 years) who had received a diagnosis of AV+BV were randomly assigned into clindamycin positive control (n = 41) and Fufang Furong Effervescent Suppository (n = 39) groups. Read More

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Clustering Analysis of the Multi-Microbial Consortium by Species Against Vaginal Dysbiosis Among Ecuadorian Women.

Front Cell Infect Microbiol 2022 11;12:863208. Epub 2022 May 11.

Universidad San Francisco de Quito USFQ, Colegio de Ciencias Biológicas y Ambientales COCIBA, Instituto de Microbiología, Laboratorio de Bacteriología, Quito, Ecuador.

The vaginal microbiota plays vital protection in women. This probiotic activity is caused not only by individual species but also by its multi-microbial interaction. However, the probiotic activity promoted by multi-microbial consortia is still unknown. Read More

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Vaginosis: Advances in new therapeutic development and microbiome restoration.

Microb Pathog 2022 Jul 26;168:105606. Epub 2022 May 26.

Centre for Nanotechnology & Advanced Biomaterials, School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur, India; School of Arts, Science, Humanities and Education, SASTRA Deemed University, Thanjavur, India. Electronic address:

Vaginosis is a condition experienced by most women at least once in their lifetime. This condition arises due to the imbalance in the microbiome of the vaginal ecosystem. Most of the pathogens of this disease are organisms which are commonly found in a normal healthy vagina. Read More

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Secnidazole: a treatment for trichomoniasis in adolescents and adults.

Expert Rev Anti Infect Ther 2022 Jun 8:1-10. Epub 2022 Jun 8.

Clinical Division, Comprehensive Pharmacy Services, Woodstock.

Introduction: Single-dose 2-g oral secnidazole (SEC), newly approved by the U.S. Food and Drug administration (FDA) for treatment of trichomoniasis, is a potent 5-nitroimidazole with selective toxicity against various micro-organisms. Read More

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Douching cessation and molecular bacterial vaginosis: a reanalysis of archived specimens.

Sex Transm Infect 2022 May 30. Epub 2022 May 30.

Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA

Objectives: Observational studies demonstrate an association between vaginal douching and bacterial vaginosis (BV) characterised by Gram stain. We sought to describe the effect of a douching cessation intervention on the composition and structure of the vaginal microbiota and molecular-BV, a state defined by low levels of spp evaluated by molecular tools.

Methods: 33 women self-collected mid-vaginal swabs twice weekly (982 samples) during a douching observation phase (4 weeks) followed by a douching cessation phase (12 weeks) in a 2005 single crossover pilot study conducted in Baltimore, Maryland. Read More

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Addressing the challenges with bacterial vaginosis pharmacotherapy.

Nuno Cerca

Expert Opin Pharmacother 2022 May 30:1-3. Epub 2022 May 30.

Laboratory of Research in Biofilms Rosário Oliveira (LIBRO), Centre of Biological Engineering (CEB), University of Minho, Campus de Gualtar, Braga, Portugal.

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Exploring of probiotic potential vaginal lactobacillus isolates from healthy women against Gardnerella vaginalis and Caenorhabditis elegans model testing.

J Appl Microbiol 2022 May 28. Epub 2022 May 28.

Department of Pharmaceutical Microbiology, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.

Aim: Lactobacillus species are the dominant microorganisms in the vaginal microbiota of healthy women and play an important role in the defence against pathogens. This study aimed to evaluate probiotic potential of Lactiplantibacillus plantarum strain P1 isolated from healthy woman's vaginal discharge for its further utilization as a promising candidate strain in the treatment of bacterial vaginosis caused by Gardnerella vaginalis.

Methods And Results: Ten lactobacilli strains from a woman's vaginal discharge were evaluated for their probiotic potential, including growth capacity at different pH levels (pH 3. Read More

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Evaluation of a Multiplex Real-Time PCR Assay for Detecting in Vaginal Samples.

Diagnostics (Basel) 2022 May 4;12(5). Epub 2022 May 4.

Institute of Microbiology, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.

is an important cause of sexually transmitted infections (STI) in Western countries. It is often asymptomatic, and thus, left untreated, and can have severe negative consequences, such as tubal infertility or adverse pregnancy outcomes. Other sexually transmitted microorganisms, such as and , as well as normal residents of the vaginal flora, such as genital mycoplasmas, also negatively impact human sexual and reproductive health. Read More

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Exploiting the Anti-Biofilm Effect of the Engineered Phage Endolysin PM-477 to Disrupt In Vitro Single- and Dual-Species Biofilms of Vaginal Pathogens Associated with Bacterial Vaginosis.

Antibiotics (Basel) 2022 Apr 22;11(5). Epub 2022 Apr 22.

Centre of Biological Engineering (CEB), Laboratory of Research in Biofilms Rosário Oliveira (LIBRO), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal.

Bacterial vaginosis (BV) is the most frequent vaginal infection in women of reproductive age. It is caused by the overgrowth of anaerobic vaginal pathogens, such as , , and , which are vaginal pathogens detected during the early stages of incident BV and have been found to form multi-species biofilms. Treatment of biofilm-associated infections, such as BV, is challenging. Read More

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Aerobic vaginitis in the third trimester and its impact on pregnancy outcomes.

BMC Pregnancy Childbirth 2022 May 24;22(1):432. Epub 2022 May 24.

Department of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411, Tartu, EE, Estonia.

Background: Aerobic vaginitis (AV) is a vaginal inflammation characterized by disruption of the lactobacillus microbiota and increased counts of different aerobic bacteria. AV may result in severe complications, especially during pregnancy, including preterm delivery, neonatal and maternal infections. This study aimed to determine the prevalence of AV in the third trimester of pregnancy, and the relationship between AV and pregnancy outcomes. Read More

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