42,708 results match your criteria Bacterial Pneumonia


Antibacterial Properties of Polysulfone Membranes Blended with Arabic Gum.

Membranes (Basel) 2019 Feb 14;9(2). Epub 2019 Feb 14.

Qatar Environment and Energy Research Institute (QEERI) Hamad Bin Khalifa University (HBKU), P.O. Box 34110 Doha, Qatar.

Polysulfone (PS) membranes blended with different loadings of arabic gum (AG) were synthesized using phase inversion method and the antibacterial properties of the synthesized membranes were tested using a number Gram-negative (, and ) and Gram-positive () bacterial species. It was shown that AG addition to the dope polymer solutions essentially changed porous structure, hydrophilicity and zeta potential of the cast PS/AG membranes. These changes were due to the amphiphilic properties of AG macromolecules that contained negatively charged hydrophilic residues. Read More

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http://dx.doi.org/10.3390/membranes9020029DOI Listing
February 2019

[Experience of application of the PCR for identification of the causative agent of community acquired pneumonia in the military.]

Klin Lab Diagn 2018 ;63(10):641-645

«1586 Military Clinical Hospital» of the Ministry of Defense of the Russian Federation, 603105, Nizhniy Novgorod, Russian Federation.

Samples of sputum, blood, bronchoalveolar lavage, swabs from the oropharynx from 255 military personnel undergoing in-patient treatment with an x-ray confirmed diagnosis of community-acquired pneumonia (CAP) were examined by polymerase chain reaction (PCR). The comparison group was included 270 healthy recruits. The detection of S. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-10-641-645DOI Listing
January 2018

Pharmaceutical Approval Update.

P T 2019 Jan;44(2):42-44

Arikayce (amikacin liposome inhalation suspension) for complex lung disease; Xofluza (baloxavir marboxil) for acute uncomplicated influenza; and Nuzyra (omadacycline) for community-acquired bacterial pneumonia and/or acute bacterial skin and skin structure infections. Read More

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January 2019

Rare Earth Element (REE) Nd Doped CeO₂ Nanoparticles Using Leaf Extract: Structural, Optical and Antimicrobial Activity.

J Nanosci Nanotechnol 2019 Jul;19(7):3964-3970

P.G and Research Department of Chemistry, A. Veeriya Vandayar Memorial Sri Pushpam College, Poondi, Thanjavur 613503, Tamil Nadu, India.

Pure and Nd-doped cerium oxides (CeO₂, CeNdO and CeNdO) nanoparticles (NPs) were synthesized using leaf extract. X-ray powder diffraction studies were confirmed that synthesized pure and Nd doped CeO₂ NPs and were exhibited cubic structure. FE-SEM image exhibited pure and Nd doped CeO₂ NPs have spherical structure and Nd doped CeO2 NPs small pores were formed in the surface. Read More

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http://dx.doi.org/10.1166/jnn.2019.16307DOI Listing

Severe Pneumonia Caused by Coinfection With Influenza Virus Followed by Methicillin-Resistant Induces Higher Mortality in Mice.

Front Immunol 2018 30;9:3189. Epub 2019 Jan 30.

Academy of Military Medical Sciences, Academy of Military Sciences, Beijing, China.

Coinfection with influenza virus and bacteria is a major cause of high mortality during flu pandemics. Understanding the mechanisms behind such coinfections is of utmost importance both for the clinical treatment of influenza and the prevention and control of epidemics. To investigate the cause of high mortality during flu pandemics, we performed coinfection experiments with H1N1 influenza virus and in which mice were infected with bacteria at time points ranging from 0 to 7 days after infection with influenza virus. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364753PMC
January 2019

Utility of qSOFA score in identifying patients at risk for poor outcome in Staphylococcus aureus bacteremia.

BMC Infect Dis 2019 Feb 13;19(1):149. Epub 2019 Feb 13.

Department of Clinical Pharmacy, University of Southern California School of Pharmacy, 1985 Zonal Ave, Los Angeles, CA, 90089, USA.

Background: The prognostic capability of the quick Sequential Organ Failure Assessment (qSOFA) bedside scoring tool is uncertain in non-ICU patients with sepsis due to bacteremia given the low number of patients previously evaluated.

Methods: We performed a retrospective cohort study of adult hospitalized patients with Staphylococcus aureus bacteremia (SAB). Medical charts were reviewed to determine qSOFA score, systemic inflammatory response syndrome (SIRS) criteria, and Pitt bacteremia score (PBS) at initial presentation; their predictive values were compared for ICU admission within 48 h, ICU stay duration > 72 h, and 30-day mortality. Read More

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http://dx.doi.org/10.1186/s12879-019-3770-4DOI Listing
February 2019

Metabolomics Reveals Anaerobic Bacterial Fermentation and Hypoxanthine Accumulation for Fibrinous Pleural Effusions in Children with Pneumonia.

J Proteome Res 2019 Feb 13. Epub 2019 Feb 13.

Fibrin formation in infectious parapneumonic effusion (IPE) characterizes complicated parapneumonic effusion and is important for providing guidelines for management of IPEs that require aggressive interventions. We aim to identify metabolic mechanisms associated with bacterial invasion, inflammatory cytokines, and biochemical markers in cases of fibrinous infectious pleural effusions in children with pneumonia. Pleural fluid metabolites were determined by 1H-nuclear magnetic resonance (NMR) spectroscopy. Read More

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http://dx.doi.org/10.1021/acs.jproteome.8b00864DOI Listing
February 2019
4.245 Impact Factor

Complementary Role of CD4+ T Cells in Response to Pneumococcal Polysaccharide Vaccines in Humans.

Vaccines (Basel) 2019 Feb 11;7(1). Epub 2019 Feb 11.

Mucosal and Vaccine Research Program Colorado (MAVRC), Infectious Diseases, University of Colorado Denver, Aurora, CO 80045, USA.

Bacterial pathogens expressing capsular polysaccharides are common causes of mucosal infections (pneumonia, intestinal), as well as often fatal, invasive infections (meningitis, bloodstream infections) in children and adults worldwide. These chemically simple but structurally complex carbohydrate structures on the bacterial surface confer resistance to recognition and clearance by the immune system through a range of mechanisms. Such recognition of capsular polysaccharides may be reduced by their limited ability to directly stimulate B cells and the T cells that may facilitate these humoral responses. Read More

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http://dx.doi.org/10.3390/vaccines7010018DOI Listing
February 2019

[Severe course of influenza B complicated by rhabdomyolysis and acute respiratory failure resulting in death].

Klin Mikrobiol Infekc Lek 2018 Dec;24(4):118-120

Department of Infectious Diseases, Faculty Hospital Ostrava, Czech Republic, e-mail:

Influenza is an acute viral disease that causes influenza A, B, C. Clinically, flu is typically characterized by fever and respiratory symptoms, sometimes with the need for mechanical ventilation, less frequently by gastrointestinal symptoms and muscle problems; severe are cases with central nervous system involvement. The most common complication of influenza is secondary bacterial infection, typically pneumonia, which is most frequently caused by pneumococci and staphylococci. Read More

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December 2018
1 Read

Dose Optimization of Colistin Combinations against Carbapenem-Resistant from Chinese Hospital-acquired Pneumonia Patients Using PK/PD Model.

Antimicrob Agents Chemother 2019 Feb 11. Epub 2019 Feb 11.

Institute of Antibiotics, Huashan Hospital, Fudan University & Key Laboratory of Clinical Pharmacology of Antibiotics, National Health and Family Planning Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China

Colistin-based combination therapy has become an important strategy to combat the carbapenem-resistant (CRAB). However, the optimal dosage regimen selection for the combination with the maximum efficacy is challenging. Checkerboard assay was employed to evaluate the synergy of colistin in combination with meropenem, rifampicin, fosfomycin and minocycline against nine carbapenem-resistant (Minimum inhibitory concentration of meropenem [MIC]≥32 mg/L) isolated from Chinese hospital-acquired pneumonia (HAP) patients. Read More

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http://dx.doi.org/10.1128/AAC.01989-18DOI Listing
February 2019
1 Read

[Microbiological analysis as effective tool for optimization of empirical antibiotic therapy in the urological clinic].

Urologiia 2018 Dec(6):45-51

Federal State Budgetary Educational Institution of Higher Education Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod.

Aim: to study the features of microbiota in patients of urological departments and to optimize the schemes of antibiotic therapy.

Materials And Methods: Data of microbiological studies in patients of urological departments in 2017 years were analyzed. Isolation of pathogens was carried out using standard techniques. Read More

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December 2018
1 Read

[The changes in urine microflora in patients with urinary stone disease].

Urologiia 2018 Dec(6):32-36

Urologic Clinic and Department of Urology.

Introduction: Since the results of treatment of chronic pyelonephritis (CP) depend on timely and rationally selected targeted antibiotic therapy, when choosing a treatment regimen, it is necessary to rely on the local data obtained by monitoring the state of microflora in a particular hospital.

Aim: to monitor the changes in urine microflora in patients with urinary stone disease.

Materials And Methods: A total of 598 isolated bacteria and yeast-like fungi from patients with urinary stone disease who were treated in the Department of Urology during different time periods (1997-1999, 2010-2014 and 2015-2017 yy) were analyzed. Read More

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December 2018
1 Read

Misidentification of and Other Species From Pediatric Infections in Mexico.

Open Forum Infect Dis 2019 Feb 18;6(2):ofz008. Epub 2019 Jan 18.

Instituto Politecnico Nacional, Escuela Nacional de Ciencias Biológicas, Mexico City, Mexico.

and complex are poorly studied in Mexico. The genotypic analysis of 38 strains isolated from children with pneumonia were identified and showed that both groups were present in patients. From our results, it is plausible to suggest that new species are among the analyzed strains. Read More

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http://dx.doi.org/10.1093/ofid/ofz008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359878PMC
February 2019
1 Read

Characterization of plant growth promoting rhizobacteria from rhizospheric soil of heat stressed and unstressed wheat and their use as bio-inoculant.

Plant Biol (Stuttg) 2019 Feb 7. Epub 2019 Feb 7.

International Centre for Chemical and Biological Sciences (ICCBS), HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.

Research Rationale: High temperature induces several proteins in plants to endure tolerance to high temperature shock. The fate of proteins synthesized in microbial cell or secreted in the culture media by the interacting microbe has not been fully elucidated. Present investigation aimed to characterize the PGPR isolated from the rhizosphere of wheat genotypes (differing in tolerance to high temperature stress) and to evaluate their performance as bioinoculant on wheat. Read More

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http://dx.doi.org/10.1111/plb.12972DOI Listing
February 2019
1 Read

A case report of severe recurrent varicella in an ankylosing spondylitis patient treated with adalimumab - a new side effect after 15 years of usage.

BMC Infect Dis 2019 Feb 7;19(1):127. Epub 2019 Feb 7.

University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Mirogojska 8, 10000, Zagreb, Croatia.

Background: Tumor necrosis factor-α (TNF-α) antagonists, most of which are monoclonal antibodies, became a widespread treatment for autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel diseases, psoriasis, psoriatic arthritis, hidradenitis suppurativa and uveitis. Their use is based on the blockage of TNF-α, which plays an important role in granulomas formation, development of phagosomes, activation and differentiation of macrophages, immune response against viral pathogens. The multiple adverse effects of TNF-α inhibition have been identified, including a two-to four-fold increased risk of active tuberculosis and other granulomatous conditions and an increased occurrence of some other serious bacterial, fungal and certain viral infections. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-019-3768-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367735PMC
February 2019
2 Reads

Mast cells participate in regulation of lung-gut axis during Staphylococcus aureus pneumonia.

Cell Prolif 2019 Feb 7:e12565. Epub 2019 Feb 7.

Department of Infectious Diseases, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Objectives: The lung-gut axis is known to be involved in the pathogenesis of Staphylococcus aureus pneumonia. However, the underlying mechanisms remain unclear. We examined the role of pulmonary mast cells (MCs) in the regulation of the lung-gut axis during S. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cpr.12565
Publisher Site
http://dx.doi.org/10.1111/cpr.12565DOI Listing
February 2019
5 Reads

The value of sPESI for risk stratification in patients with pulmonary embolism.

J Thromb Thrombolysis 2019 Feb 7. Epub 2019 Feb 7.

Janssen Scientific Affairs, LLC, Titusville, NJ, USA.

Introduction: Various risk stratification methods exist for patients with pulmonary embolism (PE). We used the simplified Pulmonary Embolism Severity Index (sPESI) as a risk-stratification method to understand the Veterans Health Administration (VHA) PE population.

Materials And Methods: Adult patients with ≥ 1 inpatient PE diagnosis (index date = discharge date) from October 2011-June 2015 as well as continuous enrollment for ≥ 12 months pre- and 3 months post-index date were included. Read More

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http://link.springer.com/10.1007/s11239-019-01814-z
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http://dx.doi.org/10.1007/s11239-019-01814-zDOI Listing
February 2019
2 Reads
2.039 Impact Factor

Canadian and UK/Ireland practice patterns in lumbar puncture performance in febrile neonates with bronchiolitis.

Emerg Med J 2019 Feb 6. Epub 2019 Feb 6.

Division of Pediatric Emergency Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Serious bacterial infections in young infants with bronchiolitis are rare. Febrile infants <1 month old with bronchiolitis often receive a lumbar puncture (LP), despite limited data for this practice and lack of clinical practice guidelines for this population. The primary objective was to investigate practice patterns in performance of LPs in the ED management of febrile infants aged ≤30 days with bronchiolitis. Read More

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http://dx.doi.org/10.1136/emermed-2018-208000DOI Listing
February 2019
1 Read

Omadacycline for Community-Acquired Bacterial Pneumonia.

N Engl J Med 2019 02;380(6):517-527

From City Clinical Hospital #6, Zaporizhzhia, Ukraine (R.S.); Sf. Pantelimon Clinical Emergency Hospital, Bucharest, Romania (M.P.); Lung Center of the Philippines, Manila (J.R.G.); Lakeview Hospital, Benoni, South Africa (I.M.); EMMS, Nazareth Hospital, Nazareth, and Faculty of Medicine in the Galilee, Bar-Ilan University, Safed - both in Israel (W.N.); the Department of Internal Medicine and Pharmacology, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland (A. Madej); AD Stats Consulting, Guerneville, CA (A.F.D.); and Paratek Pharmaceuticals, King of Prussia, PA (C.K., L.G.-R., J.N.S., A. Manley, P.B.E., E.T., P.C.M., E.L.).

Background: Omadacycline, a new once-daily aminomethylcycline antibiotic agent that can be administered intravenously or orally, reaches high concentrations in pulmonary tissues and is active against common pathogens that cause community-acquired bacterial pneumonia.

Methods: In a double-blind trial, we randomly assigned (in a 1:1 ratio) adults with community-acquired bacterial pneumonia (Pneumonia Severity Index risk class II, III, or IV) to receive omadacycline (100 mg intravenously every 12 hours for two doses, then 100 mg intravenously every 24 hours), or moxifloxacin (400 mg intravenously every 24 hours). A transition to oral omadacycline (300 mg every 24 hours) or moxifloxacin (400 mg every 24 hours), respectively, was allowed after 3 days; the total treatment duration was 7 to 14 days. Read More

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http://dx.doi.org/10.1056/NEJMoa1800201DOI Listing
February 2019
3 Reads

[New cephalosporins].

Rev Chilena Infectol 2018 ;35(5):465-475

Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.

Bacterial resistance has increased in Latin America and the world, making research and creation of new antimicrobials capable of eradicating resistant microorganisms essential. A review of new cephalosporins and their combinations with a beta-lactamase inhibitor was conducted, collecting data on the spectrum, pharmacokinetic and pharmacodynamic profile and clinical studies of the current indications for ceftaroline, and the combinations ceftazidime with avibactam and ceftolozane with tazobactam. The first one has activity against methicillin-resistant Staphylococcus aureus and coagulase negative Staphylococcus (SCoN) and against penicillin-resistant Streptococcus pneumoniae, therefore approved for use in community-acquired pneumonia and acute bacterial skin and skin structure infections. Read More

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http://dx.doi.org/10.4067/s0716-10182018000500465DOI Listing
January 2018
1 Read

Alpha-1 Antitrypsin Substitution for Extrapulmonary Conditions in Alpha-1 Antitrypsin Deficient Patients.

Chronic Obstr Pulm Dis 2018 Sep 19;5(4):267-276. Epub 2018 Sep 19.

Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder which most commonly manifests as pulmonary emphysema. Accordingly, alpha-1 antitrypsin (AAT) augmentation therapy aims to reduce the progression of emphysema, as achieved by life-long weekly slow-drip infusions of plasma-derived affinity-purified human AAT. However, not all AATD patients will receive this therapy, due to either lack of medical coverage or low patient compliance. Read More

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http://dx.doi.org/10.15326/jcopdf.5.4.2017.0161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361480PMC
September 2018
2 Reads

stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury.

Thorax 2019 Feb 5. Epub 2019 Feb 5.

Department of Pharmacology, University of Illinois, Chicago, Illinois, USA.

Introduction: Dysregulated sphingolipid metabolism has been implicated in the pathogenesis of various pulmonary disorders. Nuclear sphingosine-1-phosphate (S1P) has been shown to regulate histone acetylation, and therefore could mediate pro-inflammatory genes expression.

Methods: Profile of sphingolipid species in bronchoalveolar lavage fluids and lung tissue of mice challenged with () was investigated. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-212378DOI Listing
February 2019
1 Read

Bacterial Contamination of Circuit Inner Surfaces After High-Flow Oxygen Therapy.

Respir Care 2019 Feb 5. Epub 2019 Feb 5.

Emergency and Critical Care Medicine, Tokushima University Graduate School, Tokushima, Japan.

Background: During high-flow oxygen therapy, heated humidified gas is delivered at high flow. Although the warmth and humidity of this gas facilitates mucociliary function in the lower airway, warm and humid conditions also promote bacterial growth. Bacterial contamination of high-flow oxygen therapy circuits has not been well investigated. Read More

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http://dx.doi.org/10.4187/respcare.06299DOI Listing
February 2019

CXCL1 regulates neutrophil homeostasis in pneumonia-derived sepsis caused by serotype 3.

Blood 2019 Feb 5. Epub 2019 Feb 5.

Department of Pathobiological Sciences and Center for Experimental Infectious Disease Research, School of Veterinary Medicine, Louisiana State University (LSU), Baton Rouge, LA, United States

Neutrophil migration to the site of bacterial infection is a critical step in host defense. Exclusively produced in the bone marrow, neutrophil release into the blood is tightly controlled. Although the chemokine CXCL1 induces neutrophil influx during bacterial infections, its role in regulating neutrophil recruitment, granulopoiesis, and neutrophil mobilization in response to lung infection-induced sepsis is unclear. Read More

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http://dx.doi.org/10.1182/blood-2018-10-878082DOI Listing
February 2019
1 Read

Efficacy and Safety of IV-to-Oral Lefamulin, a Pleuromutilin Antibiotic, for Treatment of Community-Acquired Bacterial Pneumonia: The Phase 3 LEAP 1 Trial.

Clin Infect Dis 2019 Feb 4. Epub 2019 Feb 4.

Nabriva Therapeutics US, Inc., King of Prussia, PA, USA.

Background: Lefamulin, a pleuromutilin antibiotic, is active against pathogens commonly causing community-acquired bacterial pneumonia (CABP). The Lefamulin Evaluation Against Pneumonia (LEAP 1) study (NCT02559310) was a global noninferiority trial to evaluate the efficacy and safety of lefamulin for the treatment of CABP.

Methods: In this double-blind study, adults with CABP of Pneumonia Outcomes Research Team risk class ≥III were randomized 1:1 to receive lefamulin 150 mg intravenously (IV) q12h or moxifloxacin 400 mg IV q24h. Read More

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http://dx.doi.org/10.1093/cid/ciz090DOI Listing
February 2019
2 Reads

Elaboration of consensus clinical endpoints to evaluate antimicrobial treatment efficacy in future HABP/VABP clinical trials.

Clin Infect Dis 2019 Feb 4. Epub 2019 Feb 4.

Jean-François Timsit, APHP Medical and Infectious Diseases ICU, Bichat Hospital, Paris, France UMR 1137 IAME Inserm/Université Paris Diderot, Paris, France.

Background: Randomized Clinical Trials (RCTs) in Hospital-Acquired (HABP) and Ventilator-Associated Bacterial Pneumonia (VABP) are important for the evaluation of new antimicrobials. However, the heterogeneity in endpoints used in RCTs evaluating treatment of HABP/VABP may puzzle clinicians. The aim of this work was to reach a consensus on clinical endpoints to consider in future clinical trials evaluating antimicrobial treatment efficacy for HABP/VABP. Read More

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http://dx.doi.org/10.1093/cid/ciz093DOI Listing
February 2019
1 Read

Fabrication of polycaprolactone electrospun nanofibers doped with silver nanoparticles formed by air plasma treatment.

Nanotechnology 2019 Feb 4. Epub 2019 Feb 4.

McMaster University, Hamilton, Ontario, CANADA.

Implanted devices are prone to bacterial infections, which can result in implant loosening and device failure. Mitigating these infections is important to both implant stability and patient health. The development of antibacterial implant coatings can decrease the presence of bacterial colonies, reducing the risk for bacterial-dependent implant failure. Read More

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http://dx.doi.org/10.1088/1361-6528/ab0444DOI Listing
February 2019
1 Read

Long term outcome of WHIM syndrome in 18 patients: high risk of lung disease and HPV-related malignancies.

J Allergy Clin Immunol Pract 2019 Feb 1. Epub 2019 Feb 1.

the Department of Pediatrics & Department of Clinical and Experimental Sciences, Institute of Molecular Medicine "Angelo Nocivelli", University of Brescia & Asst Spedali Civili of Brescia, Brescia.

Background: In the Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) syndrome variable phenotypic expression may delay diagnosis. Panleukopenia, malignancy and chronic lung disease all affect morbidity and mortality risks. Routinely used treatments include immunoglobulins, granulocyte-colony stimulating factor (G-CSF) and antibiotics; recent trials with a target CXCR4 antagonist show promising results. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.045DOI Listing
February 2019
2 Reads

Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli.

Drugs 2019 Feb 2. Epub 2019 Feb 2.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Cefiderocol is an injectable siderophore cephalosporin discovered and being developed by Shionogi & Co., Ltd., Japan. Read More

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http://dx.doi.org/10.1007/s40265-019-1055-2DOI Listing
February 2019
2 Reads

The Double Life of Group B Streptococcus: Asymptomatic Colonizer and Potent Pathogen.

J Mol Biol 2019 Jan 31. Epub 2019 Jan 31.

Department of Global Health, University of Washington, Seattle, WA, United States of America; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States of America; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States of America. Electronic address:

Group B Streptococcus (GBS) is a β-hemolytic Gram-positive bacterium that colonizes the lower genital tract of approximately 18% of women globally as an asymptomatic member of the gastrointestinal and/or vaginal flora. If established in other host niches, however, GBS is highly pathogenic. During pregnancy, ascending GBS infection from the vagina to the intrauterine space is associated with preterm birth, stillbirth, and fetal injury. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.01.035DOI Listing
January 2019
2 Reads

Bacteriologic Profile and Susceptibility Pattern of Mechanically - Ventilated Pediatric Patients with Pneumonia.

J Glob Antimicrob Resist 2019 Jan 30. Epub 2019 Jan 30.

Department of Pediatrics, Alexandria University, Faculty of Medicine, El-Shatby Hospital, Alexandria, Egypt. Electronic address:

Purpose: Therapy of severe pneumonia is very challenging in view of the current widespread bacterial resistance to many antibiotics especially extended spectrum ß-lactams, carbapenems, and anti-pseudomonal drugs. The current study aimed at assessing antimicrobial sensitivity pattern and optimization of the antibiotic stewardship program applied in a university affiliated pediatric intensive care unit (PICU).

Subjects And Methods: This prospective cohort study included all patients aged 1 month to 12 years, admitted to the PICU with severe pneumonia episodes indicated for mechanical ventilation, and were followed up and investigated. Read More

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http://dx.doi.org/10.1016/j.jgar.2019.01.028DOI Listing
January 2019
1 Read

Controlling chronic Pseudomonas aeruginosa infections by strategically interfering with the sensory function of SagS.

Mol Microbiol 2019 Feb 2. Epub 2019 Feb 2.

Department of Biological Sciences, Binghamton University, Binghamton, NY, 13902, United States.

The hybrid sensor SagS plays a central role in the formation of P. aeruginosa biofilms, by enabling the switch from the planktonic to the biofilm mode of growth, and by facilitating the transition of biofilm cells to a highly tolerant state. In this study, we examined the importance of the SagS key amino acid residues associated with biofilm formation (L154) and antibiotic tolerance (D105) in P. Read More

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http://dx.doi.org/10.1111/mmi.14215DOI Listing
February 2019
1 Read

Biosynthesis of Ag and Cu NPs by secondary metabolites of usnic acid and thymol with biological macromolecules aggregation and antibacterial activities against multi drug resistant (MDR) bacteria.

Int J Biol Macromol 2019 Jan 29. Epub 2019 Jan 29.

Department of Nanobiotechnology, Faculty of Science, Razi University, Kermanshah, Iran; Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran. Electronic address:

Thymol and usnic acid as the important secondary metabolites of respectively Artemisia haussknechtii and Protoparmeliopsis muralis were used for reduction and stabilizing of AgNO and CuSO in metal nanoparticles (MNPs) biosynthesis process. Antibacterial effects of prepared Ag-thymol (ATNPs), Ag-usnic acid (AUNPs), Cu-thymol (CTNPs), and Cu-usnic acid (CUNPs) on multi drug resistant (MDR) bacteria including methicillin-resistant Staphylococcus aureus (MRSA) (gram positive), Acinetobacter baumannii (A52), and Klebsiella pneumonia (K38) (gram negative) were compared with thymol, usnic acid, AgNO, CuSO, and tetracycline. Results of this study showed higher antibacterial activities of usnic acid, CUNPs, and CTNPs with MIC/MBC values (20, 40, and 40 μg/mL, respectively) than ATNPs and AUNPs against MRSA bacteria. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.177DOI Listing
January 2019
2 Reads

Comparison of four adjuvants revealed the strongest protection against lethal pneumococcal challenge following immunization with PsaA-PspA fusion protein and AS02 as adjuvant.

Med Microbiol Immunol 2019 Feb 1. Epub 2019 Feb 1.

National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.

Streptococcuspneumoniae, or pneumococcus, is a major respiratory-tract pathogen that causes high levels of mortality and morbidity in infants and elderly individuals. Despite the development of various capsular polysaccharide vaccines to prevent pneumococcal disease, it remains epidemic. Pneumococcal surface protein A (PspA) is a highly immunogenic surface protein existing in all strains of S. Read More

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http://dx.doi.org/10.1007/s00430-019-00579-9DOI Listing
February 2019
1 Read

Opportunistic diseases in patients with HIV infection in the intensive care unit.

Ter Arkh 2018 Nov;90(11):13-17

Peoples Friendship University of Russia (RUDN University), Moscow, Russia.

Aim: The aim of the study was to analyze the incidence and prevalence of opportunistic diseases and comorbidities in patients admitted in the intensive care unit.

Materials And Methods: A specialized intensive care unit (ICU) for patients with severe HIV infection was set up in 2014 at the infectious diseases 2nd state hospital Moscow. It provides intensive care and treatments for HIV patients with severe co-morbidities and opportunistic infections. Read More

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http://dx.doi.org/10.26442/terarkh2018901113-17DOI Listing
November 2018
5 Reads

Loop-mediated isothermal amplification-lateral-flow dipstick (LAMP-LFD) to detect Mycoplasma ovipneumoniae.

World J Microbiol Biotechnol 2019 Jan 30;35(2):31. Epub 2019 Jan 30.

College of Life Sciences, Shihezi University, Xin Jiang, Shihezi, 832000, China.

In order to establish a rapid detection method for Mycoplasma ovipneumoniae, this study used the loop-mediated isothermal amplification (LAMP) technique to carry out nucleic acid amplification and chromatographic visualization via a lateral flow dipstick (LFD) assay. The M. ovipneumoniae elongation factor TU gene (EF-TU) was detected using a set of specific primers designed for the EF-TU gene, and the EF-TU FIP was detected by biotin labeling, which was used in the LAMP amplification reaction. Read More

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http://dx.doi.org/10.1007/s11274-019-2601-5DOI Listing
January 2019
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Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone.

Sci Rep 2019 Jan 30;9(1):971. Epub 2019 Jan 30.

Department of Medicine, Pulmonary and Critical Care, Weill Cornell Medicine, New York, NY, USA.

Pneumococcal infections remain a leading cause of death in older adults, with the most serious cases occurring in persons ≥65 years of age. There is an urgent need to investigate molecular pathways underlying these impairments and devise new therapeutics to modulate innate immunity. The goal of our current study is to understand the impact of chronological aging on mitochondrial function in response to Streptococcus pneumoniae, a causative agent of bacterial pneumonia. Read More

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http://dx.doi.org/10.1038/s41598-018-37438-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353918PMC
January 2019
2 Reads

The Role of the CopA Copper Efflux System in Virulence.

Int J Mol Sci 2019 Jan 29;20(3). Epub 2019 Jan 29.

Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, South Australia, Australia.

has emerged as one of the leading causative agents of nosocomial infections. Due to its high level of intrinsic and adapted antibiotic resistance, treatment failure rates are high, which allows this opportunistic pathogen to thrive during infection in immune-compromised patients. can cause infections within a broad range of host niches, with pneumonia and bacteraemia being associated with the greatest levels of morbidity and mortality. Read More

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http://dx.doi.org/10.3390/ijms20030575DOI Listing
January 2019
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Analysis of the Pulmonary Microbiome Composition of Legionella pneumophila-Infected Patients.

Methods Mol Biol 2019 ;1921:429-443

Institut Pasteur, Biologie des Bactéries Intracellulaires, Paris, France.

The analysis of the lung microbiome composition is a field of research that recently emerged. It gained great interest in pulmonary diseases such as pneumonia since the microbiome seems to be involved in host immune responses, inflammation, and protection against pathogens. Thus, it is possible that the microbial communities living in the lungs play a role in the outcome and severity of lung infections such as Legionella-caused pneumonia and in the response to antibiotic therapy. Read More

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http://dx.doi.org/10.1007/978-1-4939-9048-1_27DOI Listing
January 2019
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The Mouse as a Model for Pulmonary Legionella Infection.

Methods Mol Biol 2019 ;1921:399-417

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.

Infection of C57BL/6 mice with wild-type Legionella pneumophila typically results in very mild disease. However, in mice where the cytosolic recognition of flagellin is impaired by mutation, L. pneumophila infection results in more severe lung inflammation that is reminiscent of Legionnaires' disease. Read More

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http://dx.doi.org/10.1007/978-1-4939-9048-1_25DOI Listing
January 2019
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Infection of Human Lung Tissue Explants (HLTEs) with Legionella pneumophila.

Methods Mol Biol 2019 ;1921:323-331

Institut für Mikrobiologie, Technische Universität Braunschweig, Braunschweig, Germany.

Legionnaires' disease is a severe pneumonia caused by inhalation of Legionella pneumophila. Although powerful infection models ranging from monocellular host systems to mammals were developed, numerous intra- and extracellular interactions of L. pneumophila factors with human lung tissue structures remain unknown. Read More

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http://link.springer.com/10.1007/978-1-4939-9048-1_21
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http://dx.doi.org/10.1007/978-1-4939-9048-1_21DOI Listing
January 2019
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Screening Targeted Legionella pneumophila Mutant Libraries In Vivo Using INSeq.

Methods Mol Biol 2019 ;1921:123-144

Division of Biology, Kansas State University, Manhattan, KS, USA.

Legionella pneumophila is an intracellular bacterial pathogen that can cause a severe inflammatory pneumonia in humans called Legionnaires' disease, which results from bacterial replication within alveolar macrophages. L. pneumophila replication within macrophages is dependent on hundreds of individual protein virulence factors. Read More

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http://dx.doi.org/10.1007/978-1-4939-9048-1_8DOI Listing
January 2019
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PNAG-specific equine IgG mediates significantly greater opsonization and killing of Prescottella equi (formerly Rhodococcus equi) than does IgG.

Vaccine 2019 Feb 26;37(9):1142-1150. Epub 2019 Jan 26.

College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, 660 Raymond Stotzer Pkwy, College Station, TX 77843-4475, United States. Electronic address:

Prescottella equi (formerly Rhodococcus equi) is a facultative intracellular bacterial pathogen that causes severe pneumonia in foals 1-6 months of age, whereas adult horses are highly resistant to infection. We have shown that vaccinating pregnant mares against the conserved surface polysaccharide capsule, β-1 → 6-linked poly-N-acetyl glucosamine (PNAG), elicits opsonic killing antibody that transfers via colostrum to foals and protects them against experimental infection with virulent. R. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.028DOI Listing
February 2019
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Staphylococcus pseudintermedius septicemia in puppies after elective cesarean section: confirmed transmission via dam's milk.

BMC Vet Res 2019 Jan 28;15(1):41. Epub 2019 Jan 28.

Clinic for Reproduction and Large Animals, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000, Ljubljana, Slovenia.

Background: In humans, transmission of bacteria causing fatal sepsis in the neonates through mother's milk has been reported. In dogs, it is believed that bacteria from canine milk are not the primary cause of neonatal infections. Staphylococcus pseudintermedius is colonizing the skin and mucocutaneous junctions in adult dogs and can act as an opportunistic pathogen. Read More

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http://dx.doi.org/10.1186/s12917-019-1795-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348621PMC
January 2019
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Effect of experimental Ornithobacterium rhinotracheale infection along with live infectious bronchitis vaccination in broiler chickens.

Poult Sci 2019 Jan;98(1):105-111

Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.

Ornithobacterium rhinotracheale (ORT), a bacterium causing respiratory tract infection, has led to a significant problem in the intensive poultry production in Egypt. Polymerase chain reaction-amplified 784-bp specific ORT DNA fragments were found in 7 ORT isolates from lungs, air sacs, and tracheas of commercial broilers or layers in Egypt in 2015. The objective of this study was to investigate the role of the live variant IBV 4/91 with ORT infection. Read More

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http://dx.doi.org/10.3382/ps/pey324DOI Listing
January 2019
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Aquaporin 5 -1364A/C Promoter Polymorphism Is Associated with Pulmonary Inflammation and Survival in Acute Respiratory Distress Syndrome.

Anesthesiology 2019 Mar;130(3):404-413

From the Department of Anesthesia, Intensive Care Medicine, and Pain Therapy, University Hospital Knappschaftskrankenhaus Bochum, Bochum, Germany (T.R., K.R., M.A.) Department of Anesthesia and Intensive Care Medicine, University Duisburg-Essen and University Hospital Essen, Essen, Germany (J.P., M.A.).

What We Already Know About This Topic: Acute respiratory distress syndrome is defined according to clinical criteria, but lack of precise characterization may contribute to negative trials and impede personalized care. Polymorphisms of aquaporin-5, a key mediator of inflammation, may impact outcome.

What This Article Tells Us That Is New: In acute respiratory distress syndrome attributable to bacterial pneumonia, the C-allele of the aquaporin-5 -1364A/C promoter polymorphism is associated with less pulmonary inflammation and greater survival. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002560DOI Listing
March 2019
2 Reads
5.879 Impact Factor

Agmatine accumulation by Pseudomonas aeruginosa clinical isolates confers antibiotic tolerance and dampens host inflammation.

J Med Microbiol 2019 Jan 28. Epub 2019 Jan 28.

1​Department of Microbiology & Immunology, University of Minnesota, Minneapolis, MN 55455, USA.

Purpose: In the cystic fibrosis (CF) airways, Pseudomonas aeruginosa undergoes diverse physiological changes in response to inflammation, antibiotic pressure, oxidative stress and a dynamic bioavailable nutrient pool. These include loss-of-function mutations that result in reduced virulence, altered metabolism and other phenotypes that are thought to confer a selective advantage for long-term persistence. Recently, clinical isolates of P. Read More

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http://dx.doi.org/10.1099/jmm.0.000928DOI Listing
January 2019
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Role of Probiotics in Pneumonia in Children: A Short-Term Pilot Project.

Front Microbiol 2018 9;9:3261. Epub 2019 Jan 9.

Department of Gastroenterology, Affiliated Beijing Children's Hospital, Capital Medical University, Beijing, China.

is one of the most common pathogens causing community-acquired pneumonia in children. pneumonia (MPP) can be successfully treated with azithromycin; however, antibiotic-associated diarrhea (AAD) is a common adverse effect. Increasing evidence suggests that some probiotics may prevent the development of AAD. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334620PMC
January 2019
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Recruitment manoeuvres dislodge mucus towards the distal airways in an experimental model of severe pneumonia.

Br J Anaesth 2019 Feb 10;122(2):269-276. Epub 2018 Nov 10.

Department of Pulmonary and Critical Care Medicine, Hospital Clinic, Barcelona, Spain; University of Barcelona, Barcelona, Spain; CIBER Enfermedades Respiratorias (CIBERES), Mallorca, Spain; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain. Electronic address:

Background: Recruitment manoeuvres generate a transient increase in trans-pulmonary pressure that could open collapsed alveoli. Recruitment manoeuvres might generate very high inspiratory airflows. We evaluated whether recruitment manoeuvres could displace respiratory secretions towards the distal airways and impair gas exchange in a porcine model of bacterial pneumonia. Read More

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http://dx.doi.org/10.1016/j.bja.2018.07.039DOI Listing
February 2019
2 Reads

A case of acute skin failure misdiagnosed as a pressure ulcer, leading to a legal dispute.

Arch Plast Surg 2019 Jan 15;46(1):75-78. Epub 2019 Jan 15.

Department of Plastic and Reconstructive Surgery, Dongguk University College of Medicine, Gyeongju, Korea.

It is difficult to differentiate acute skin failure (ASF) from pressure ulcer (PU). ASF is defined as unavoidable injury resulting from hypoperfusion caused by severe dysfunction of another organ system. We describe a case of ASF mistaken as PU that resulted in a legal dispute. Read More

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http://e-aps.org/journal/view.php?doi=10.5999/aps.2018.00087
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http://dx.doi.org/10.5999/aps.2018.00087DOI Listing
January 2019
9 Reads